acetaminophen has been researched along with Epilepsy in 15 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Secondary outcome measures are postoperative pain intensity scores, psychological parameters, length of hospital stay and adverse events and will be reassessed at 3 and 6 months after surgery, with a baseline measurement preoperatively." | 6.90 | Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial. ( Bastiaenen, C; Bos, M; Colon, A; Dings, J; Hoogland, G; Rijkers, K; Rouhl, RPW; Schijns, OEMG; Sloekers, JCT; Theunissen, M; van Kuijk, S, 2019) |
| " Although it has been reported that AM404, a metabolite of acetaminophen, has anticonvulsant effects in several animal seizure models, little is known about the relation between acetaminophen and seizures." | 3.88 | Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs. ( Araki, H; Aso, H; Suemaru, K; Tanaka, A; Watanabe, M; Yoshikawa, M, 2018) |
| "Acetaminophen metabolism and clearance after a single 1 gm oral dose of the drug was investigated in 12 healthy men, six of whom were cigarette smokers, and in six men who were receiving anticonvulsant drugs for epilepsy." | 3.67 | Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways. ( Attwood, J; Birkett, DJ; Miners, JO, 1984) |
| "Recently, seizure-induced cyclooxygenase (COX)-mediated postictal vasoconstriction, accompanied by cerebral hypoperfusion and hypoxia, has been identified as a candidate mechanism in experimentally induced seizures in rats." | 3.11 | Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE). ( Hofmeijer, J; Pottkämper, JCM; van Putten, MJAM; van Waarde, JA; van Wingen, GA; Verdijk, JPAJ; Verwijk, E, 2022) |
| "Secondary outcome measures are postoperative pain intensity scores, psychological parameters, length of hospital stay and adverse events and will be reassessed at 3 and 6 months after surgery, with a baseline measurement preoperatively." | 2.90 | Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial. ( Bastiaenen, C; Bos, M; Colon, A; Dings, J; Hoogland, G; Rijkers, K; Rouhl, RPW; Schijns, OEMG; Sloekers, JCT; Theunissen, M; van Kuijk, S, 2019) |
| "Pharmacotherapy in pregnancy is often problematic, since both the mother-to-be and her doctor are often concerned about possible risks for the unborn child." | 2.42 | [Drug therapy in pregnancy--a practical guide]. ( Kreienberg, R; Paulus, W; Reister, F, 2004) |
| " Our aim was to translate a recently published comprehensive CNS physiologically-based pharmacokinetic (PBPK) model from rat to human, and to predict drug concentration-time profiles in multiple CNS compartments on available human data of four drugs (acetaminophen, oxycodone, morphine and phenytoin)." | 1.48 | Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach. ( Beukers, MW; Danhof, M; de Lange, ECM; Huntjens, DR; Kokki, H; Kokki, M; Krauwinkel, W; Proost, JH; Välitalo, PA; van Hasselt, JGC; Vermeulen, A; Wong, YC; Yamamoto, Y, 2018) |
| "Migraine is common in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) but its treatment responses are not well described, and its relationship to stroke risk unknown." | 1.43 | CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships. ( Markus, HS; Tan, RY, 2016) |
| "Ibuprofen was more effective against the primary generalized model." | 1.27 | Attenuation of penicillin models of epilepsy by nonsteroidal anti-inflammatory drugs. ( Wallenstein, MC, 1987) |
| "A high proportion of toxic and carcinogenic effects of chemicals develop through the pathway of lethal synthesis." | 1.26 | The influence of nutrition and inducers on mechanisms of toxicity in humans and animals. ( McLean, AE; Tame, D; Witts, DJ, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (46.67) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Verdijk, JPAJ | 1 |
| Pottkämper, JCM | 1 |
| Verwijk, E | 1 |
| van Wingen, GA | 1 |
| van Putten, MJAM | 1 |
| Hofmeijer, J | 1 |
| van Waarde, JA | 1 |
| Sha, L | 1 |
| Li, G | 1 |
| Zhang, X | 1 |
| Lin, Y | 1 |
| Qiu, Y | 1 |
| Deng, Y | 1 |
| Zhu, W | 1 |
| Xu, Q | 1 |
| Sloekers, JCT | 1 |
| Bos, M | 1 |
| Hoogland, G | 1 |
| Bastiaenen, C | 1 |
| van Kuijk, S | 1 |
| Theunissen, M | 1 |
| Rijkers, K | 1 |
| Dings, J | 1 |
| Colon, A | 1 |
| Rouhl, RPW | 1 |
| Schijns, OEMG | 1 |
| Yamamoto, Y | 1 |
| Välitalo, PA | 1 |
| Wong, YC | 1 |
| Huntjens, DR | 1 |
| Proost, JH | 1 |
| Vermeulen, A | 1 |
| Krauwinkel, W | 1 |
| Beukers, MW | 1 |
| Kokki, H | 1 |
| Kokki, M | 1 |
| Danhof, M | 1 |
| van Hasselt, JGC | 1 |
| de Lange, ECM | 1 |
| Suemaru, K | 1 |
| Yoshikawa, M | 1 |
| Tanaka, A | 1 |
| Araki, H | 1 |
| Aso, H | 1 |
| Watanabe, M | 1 |
| Tan, RY | 1 |
| Markus, HS | 1 |
| Reister, F | 1 |
| Paulus, W | 1 |
| Kreienberg, R | 1 |
| Miners, JO | 1 |
| Attwood, J | 1 |
| Birkett, DJ | 1 |
| Kapetanović, IM | 1 |
| Kupferberg, HJ | 1 |
| Theodore, W | 1 |
| Porter, RJ | 1 |
| McLean, AE | 2 |
| Witts, DJ | 1 |
| Tame, D | 1 |
| Goldberg, DM | 1 |
| Ernouf, D | 1 |
| Boussa, N | 1 |
| Wallenstein, MC | 1 |
| Minton, NA | 1 |
| Henry, JA | 1 |
| Frankel, RJ | 1 |
| Driver, HE | 1 |
| McDanell, R | 1 |
| Tacchi-Bedford, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| StudY of Effect of Nimodipine and Acetaminophen on Postictal Symptoms After ECT[NCT04028596] | Phase 2 | 34 participants (Actual) | Interventional | 2019-12-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for acetaminophen and Epilepsy
| Article | Year |
|---|---|
[Drug therapy in pregnancy--a practical guide].
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Bacte | 2004 |
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry.
Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; E | 1980 |
The influence of diet on activation and inactivation of chemicals--evidence from animals and man.
Topics: 1,2-Dimethylhydrazine; Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Co | 1986 |
2 trials available for acetaminophen and Epilepsy
| Article | Year |
|---|---|
Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE).
Topics: Acetaminophen; Animals; Depressive Disorder, Major; Electroconvulsive Therapy; Electroencephalograph | 2022 |
Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug Combinations; | 2019 |
10 other studies available for acetaminophen and Epilepsy
| Article | Year |
|---|---|
Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice.
Topics: Acetaminophen; Animals; Anticonvulsants; Epilepsy; Epilepsy, Temporal Lobe; Excitatory Amino Acid Tr | 2022 |
Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach.
Topics: Acetaminophen; Animals; Biological Transport; Brain; Brain Injuries, Traumatic; Central Nervous Syst | 2018 |
Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cyclooxygenase Inh | 2018 |
CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships.
Topics: Acetaminophen; Adult; Age of Onset; Aged; Aged, 80 and over; Analgesics; CADASIL; Codeine; Cross-Sec | 2016 |
Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways.
Topics: Acetaminophen; Administration, Oral; Adult; Anticonvulsants; Biotransformation; Cimetidine; Drug Int | 1984 |
Lack of effect of valproate on paracetamol (acetaminophen) disposition in epileptic patients.
Topics: Acetaminophen; Adult; Drug Interactions; Epilepsy; Humans; Kinetics; Male; Valproic Acid | 1981 |
The influence of nutrition and inducers on mechanisms of toxicity in humans and animals.
Topics: Acetaminophen; Animals; Anticonvulsants; Calcium; Carcinogens; Cytochrome P-450 Enzyme System; Epile | 1980 |
[Paracetamol, a good analgesic? Yes, but ...].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Epilepsy; Humans | 1990 |
Attenuation of penicillin models of epilepsy by nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids | 1987 |
Fatal paracetamol poisoning in an epileptic.
Topics: Acetaminophen; Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clobazam; Cytochrome | 1988 |