Page last updated: 2024-10-22

acetaminophen and Endotoxemia

acetaminophen has been researched along with Endotoxemia in 6 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.

Research Excerpts

ExcerptRelevanceReference
"Acetaminophen was the superior antipyretic drug in endotoxemia compared with aspirin."9.09Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial. ( Bieglmayer, C; Eichler, HG; Jilma, B; Kapiotis, S; Pernerstorfer, T; Schmid, R, 1999)
"To determine the pharmacokinetics and efficacy of acetaminophen compared to placebo and flunixin meglumine in adult horses with experimentally induced endotoxemia."8.31Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia. ( Council-Troche, RM; Davis, JL; McKenzie, HC; Mercer, MA; Messenger, KM; Schaefer, E; Werre, SR, 2023)
"Pigs treated with acetaminophen survived with no obvious hemodynamic instability during the 50-min observation period."5.91ACETAMINOPHEN ATTENUATES PULMONARY VASCULAR RESISTANCE AND PULMONARY ARTERIAL PRESSURE AND INHIBITS CARDIOVASCULAR COLLAPSE IN A PORCINE MODEL OF ENDOTOXEMIA. ( Bergström, A; Chew, MS; Elander, L; Engblom, D; Larsson, A; Lipcsey, M; Yang, B, 2023)
"Acetaminophen was the superior antipyretic drug in endotoxemia compared with aspirin."5.09Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial. ( Bieglmayer, C; Eichler, HG; Jilma, B; Kapiotis, S; Pernerstorfer, T; Schmid, R, 1999)
"To determine the pharmacokinetics and efficacy of acetaminophen compared to placebo and flunixin meglumine in adult horses with experimentally induced endotoxemia."4.31Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia. ( Council-Troche, RM; Davis, JL; McKenzie, HC; Mercer, MA; Messenger, KM; Schaefer, E; Werre, SR, 2023)
"Pigs treated with acetaminophen survived with no obvious hemodynamic instability during the 50-min observation period."1.91ACETAMINOPHEN ATTENUATES PULMONARY VASCULAR RESISTANCE AND PULMONARY ARTERIAL PRESSURE AND INHIBITS CARDIOVASCULAR COLLAPSE IN A PORCINE MODEL OF ENDOTOXEMIA. ( Bergström, A; Chew, MS; Elander, L; Engblom, D; Larsson, A; Lipcsey, M; Yang, B, 2023)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's2 (33.33)2.80

Authors

AuthorsStudies
Bergström, A1
Lipcsey, M1
Larsson, A1
Yang, B1
Engblom, D1
Chew, MS1
Elander, L1
Mercer, MA1
Davis, JL1
McKenzie, HC1
Messenger, KM1
Schaefer, E1
Council-Troche, RM1
Werre, SR1
Scheiermann, P1
Bachmann, M1
Härdle, L1
Pleli, T1
Piiper, A1
Zwissler, B1
Pfeilschifter, J1
Mühl, H1
Marshall, M1
Keeble, J1
Moore, PK1
Jilma, B2
Blann, A1
Pernerstorfer, T2
Stohlawetz, P1
Eichler, HG2
Vondrovec, B1
Amiral, J1
Richter, V1
Wagner, OF1
Schmid, R1
Bieglmayer, C1
Kapiotis, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation[NCT01099566]Phase 420 participants (Actual)Interventional2009-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for acetaminophen and Endotoxemia

ArticleYear
Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin.
    American journal of respiratory and critical care medicine, 1999, Volume: 159, Issue:3

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Adhesion Molecules; Dou

1999
Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial.
    Clinical pharmacology and therapeutics, 1999, Volume: 66, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Aspirin; Body Temperature; Double-Blind Method; Endo

1999

Other Studies

4 other studies available for acetaminophen and Endotoxemia

ArticleYear
ACETAMINOPHEN ATTENUATES PULMONARY VASCULAR RESISTANCE AND PULMONARY ARTERIAL PRESSURE AND INHIBITS CARDIOVASCULAR COLLAPSE IN A PORCINE MODEL OF ENDOTOXEMIA.
    Shock (Augusta, Ga.), 2023, 03-01, Volume: 59, Issue:3

    Topics: Acetaminophen; Animals; Arterial Pressure; Blood Pressure; Endotoxemia; Endotoxins; Hemodynamics; Sh

2023
Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia.
    Journal of veterinary internal medicine, 2023, Volume: 37, Issue:2

    Topics: Acetaminophen; Animals; Chromatography, Liquid; Cross-Over Studies; Endotoxemia; Horse Diseases; Hor

2023
Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury.
    Scientific reports, 2015, Feb-17, Volume: 5

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemokine CCL20; Disease Models, Ani

2015
Effect of a nitric oxide releasing derivative of paracetamol in a rat model of endotoxaemia.
    British journal of pharmacology, 2006, Volume: 149, Issue:5

    Topics: Acetaminophen; Acetylcholine; Animals; Aspartate Aminotransferases; Blood Pressure; Creatinine; Cycl

2006