acetaminophen has been researched along with Endotoxemia in 6 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen was the superior antipyretic drug in endotoxemia compared with aspirin." | 9.09 | Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial. ( Bieglmayer, C; Eichler, HG; Jilma, B; Kapiotis, S; Pernerstorfer, T; Schmid, R, 1999) |
| "To determine the pharmacokinetics and efficacy of acetaminophen compared to placebo and flunixin meglumine in adult horses with experimentally induced endotoxemia." | 8.31 | Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia. ( Council-Troche, RM; Davis, JL; McKenzie, HC; Mercer, MA; Messenger, KM; Schaefer, E; Werre, SR, 2023) |
| "Pigs treated with acetaminophen survived with no obvious hemodynamic instability during the 50-min observation period." | 5.91 | ACETAMINOPHEN ATTENUATES PULMONARY VASCULAR RESISTANCE AND PULMONARY ARTERIAL PRESSURE AND INHIBITS CARDIOVASCULAR COLLAPSE IN A PORCINE MODEL OF ENDOTOXEMIA. ( Bergström, A; Chew, MS; Elander, L; Engblom, D; Larsson, A; Lipcsey, M; Yang, B, 2023) |
| "Acetaminophen was the superior antipyretic drug in endotoxemia compared with aspirin." | 5.09 | Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial. ( Bieglmayer, C; Eichler, HG; Jilma, B; Kapiotis, S; Pernerstorfer, T; Schmid, R, 1999) |
| "To determine the pharmacokinetics and efficacy of acetaminophen compared to placebo and flunixin meglumine in adult horses with experimentally induced endotoxemia." | 4.31 | Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia. ( Council-Troche, RM; Davis, JL; McKenzie, HC; Mercer, MA; Messenger, KM; Schaefer, E; Werre, SR, 2023) |
| "Pigs treated with acetaminophen survived with no obvious hemodynamic instability during the 50-min observation period." | 1.91 | ACETAMINOPHEN ATTENUATES PULMONARY VASCULAR RESISTANCE AND PULMONARY ARTERIAL PRESSURE AND INHIBITS CARDIOVASCULAR COLLAPSE IN A PORCINE MODEL OF ENDOTOXEMIA. ( Bergström, A; Chew, MS; Elander, L; Engblom, D; Larsson, A; Lipcsey, M; Yang, B, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Bergström, A | 1 |
| Lipcsey, M | 1 |
| Larsson, A | 1 |
| Yang, B | 1 |
| Engblom, D | 1 |
| Chew, MS | 1 |
| Elander, L | 1 |
| Mercer, MA | 1 |
| Davis, JL | 1 |
| McKenzie, HC | 1 |
| Messenger, KM | 1 |
| Schaefer, E | 1 |
| Council-Troche, RM | 1 |
| Werre, SR | 1 |
| Scheiermann, P | 1 |
| Bachmann, M | 1 |
| Härdle, L | 1 |
| Pleli, T | 1 |
| Piiper, A | 1 |
| Zwissler, B | 1 |
| Pfeilschifter, J | 1 |
| Mühl, H | 1 |
| Marshall, M | 1 |
| Keeble, J | 1 |
| Moore, PK | 1 |
| Jilma, B | 2 |
| Blann, A | 1 |
| Pernerstorfer, T | 2 |
| Stohlawetz, P | 1 |
| Eichler, HG | 2 |
| Vondrovec, B | 1 |
| Amiral, J | 1 |
| Richter, V | 1 |
| Wagner, OF | 1 |
| Schmid, R | 1 |
| Bieglmayer, C | 1 |
| Kapiotis, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation[NCT01099566] | Phase 4 | 20 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for acetaminophen and Endotoxemia
| Article | Year |
|---|---|
Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Adhesion Molecules; Dou | 1999 |
Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Aspirin; Body Temperature; Double-Blind Method; Endo | 1999 |
4 other studies available for acetaminophen and Endotoxemia
| Article | Year |
|---|---|
ACETAMINOPHEN ATTENUATES PULMONARY VASCULAR RESISTANCE AND PULMONARY ARTERIAL PRESSURE AND INHIBITS CARDIOVASCULAR COLLAPSE IN A PORCINE MODEL OF ENDOTOXEMIA.
Topics: Acetaminophen; Animals; Arterial Pressure; Blood Pressure; Endotoxemia; Endotoxins; Hemodynamics; Sh | 2023 |
Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia.
Topics: Acetaminophen; Animals; Chromatography, Liquid; Cross-Over Studies; Endotoxemia; Horse Diseases; Hor | 2023 |
Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemokine CCL20; Disease Models, Ani | 2015 |
Effect of a nitric oxide releasing derivative of paracetamol in a rat model of endotoxaemia.
Topics: Acetaminophen; Acetylcholine; Animals; Aspartate Aminotransferases; Blood Pressure; Creatinine; Cycl | 2006 |