acetaminophen has been researched along with Endotoxemia in 6 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
Excerpt | Relevance | Reference |
---|---|---|
"Acetaminophen was the superior antipyretic drug in endotoxemia compared with aspirin." | 9.09 | Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial. ( Bieglmayer, C; Eichler, HG; Jilma, B; Kapiotis, S; Pernerstorfer, T; Schmid, R, 1999) |
"To determine the pharmacokinetics and efficacy of acetaminophen compared to placebo and flunixin meglumine in adult horses with experimentally induced endotoxemia." | 8.31 | Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia. ( Council-Troche, RM; Davis, JL; McKenzie, HC; Mercer, MA; Messenger, KM; Schaefer, E; Werre, SR, 2023) |
"Pigs treated with acetaminophen survived with no obvious hemodynamic instability during the 50-min observation period." | 5.91 | ACETAMINOPHEN ATTENUATES PULMONARY VASCULAR RESISTANCE AND PULMONARY ARTERIAL PRESSURE AND INHIBITS CARDIOVASCULAR COLLAPSE IN A PORCINE MODEL OF ENDOTOXEMIA. ( Bergström, A; Chew, MS; Elander, L; Engblom, D; Larsson, A; Lipcsey, M; Yang, B, 2023) |
"Acetaminophen was the superior antipyretic drug in endotoxemia compared with aspirin." | 5.09 | Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial. ( Bieglmayer, C; Eichler, HG; Jilma, B; Kapiotis, S; Pernerstorfer, T; Schmid, R, 1999) |
"To determine the pharmacokinetics and efficacy of acetaminophen compared to placebo and flunixin meglumine in adult horses with experimentally induced endotoxemia." | 4.31 | Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia. ( Council-Troche, RM; Davis, JL; McKenzie, HC; Mercer, MA; Messenger, KM; Schaefer, E; Werre, SR, 2023) |
"Pigs treated with acetaminophen survived with no obvious hemodynamic instability during the 50-min observation period." | 1.91 | ACETAMINOPHEN ATTENUATES PULMONARY VASCULAR RESISTANCE AND PULMONARY ARTERIAL PRESSURE AND INHIBITS CARDIOVASCULAR COLLAPSE IN A PORCINE MODEL OF ENDOTOXEMIA. ( Bergström, A; Chew, MS; Elander, L; Engblom, D; Larsson, A; Lipcsey, M; Yang, B, 2023) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (33.33) | 18.2507 |
2000's | 1 (16.67) | 29.6817 |
2010's | 1 (16.67) | 24.3611 |
2020's | 2 (33.33) | 2.80 |
Authors | Studies |
---|---|
Bergström, A | 1 |
Lipcsey, M | 1 |
Larsson, A | 1 |
Yang, B | 1 |
Engblom, D | 1 |
Chew, MS | 1 |
Elander, L | 1 |
Mercer, MA | 1 |
Davis, JL | 1 |
McKenzie, HC | 1 |
Messenger, KM | 1 |
Schaefer, E | 1 |
Council-Troche, RM | 1 |
Werre, SR | 1 |
Scheiermann, P | 1 |
Bachmann, M | 1 |
Härdle, L | 1 |
Pleli, T | 1 |
Piiper, A | 1 |
Zwissler, B | 1 |
Pfeilschifter, J | 1 |
Mühl, H | 1 |
Marshall, M | 1 |
Keeble, J | 1 |
Moore, PK | 1 |
Jilma, B | 2 |
Blann, A | 1 |
Pernerstorfer, T | 2 |
Stohlawetz, P | 1 |
Eichler, HG | 2 |
Vondrovec, B | 1 |
Amiral, J | 1 |
Richter, V | 1 |
Wagner, OF | 1 |
Schmid, R | 1 |
Bieglmayer, C | 1 |
Kapiotis, S | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation[NCT01099566] | Phase 4 | 20 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
2 trials available for acetaminophen and Endotoxemia
Article | Year |
---|---|
Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Adhesion Molecules; Dou | 1999 |
Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Aspirin; Body Temperature; Double-Blind Method; Endo | 1999 |
4 other studies available for acetaminophen and Endotoxemia
Article | Year |
---|---|
ACETAMINOPHEN ATTENUATES PULMONARY VASCULAR RESISTANCE AND PULMONARY ARTERIAL PRESSURE AND INHIBITS CARDIOVASCULAR COLLAPSE IN A PORCINE MODEL OF ENDOTOXEMIA.
Topics: Acetaminophen; Animals; Arterial Pressure; Blood Pressure; Endotoxemia; Endotoxins; Hemodynamics; Sh | 2023 |
Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia.
Topics: Acetaminophen; Animals; Chromatography, Liquid; Cross-Over Studies; Endotoxemia; Horse Diseases; Hor | 2023 |
Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemokine CCL20; Disease Models, Ani | 2015 |
Effect of a nitric oxide releasing derivative of paracetamol in a rat model of endotoxaemia.
Topics: Acetaminophen; Acetylcholine; Animals; Aspartate Aminotransferases; Blood Pressure; Creatinine; Cycl | 2006 |