acetaminophen and Ductus Arteriosus, Patent studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Ductus Arteriosus, Patent: A congenital heart defect characterized by the persistent opening of fetal DUCTUS ARTERIOSUS that connects the PULMONARY ARTERY to the descending aorta (AORTA, DESCENDING) allowing unoxygenated blood to bypass the lung and flow to the PLACENTA. Normally, the ductus is closed shortly after birth.

Research Excerpts

Excerpt	Relevance	Reference
"Paracetamol or acetaminophen (APAP) is commonly used as a first line treatment of pain and fever in pregnancy."	7.88	Paracetamol/Acetaminophen During Pregnancy Induces Prenatal Ductus Arteriosus Closure. ( Allegaert, K; Becquet, O; Bonnet, D; Lapillonne, A; Ville, Y, 2018)
" This article critically evaluated the literature reporting an association between acetaminophen use and in utero ductus arteriosus closure and provided a comparative pharmacokinetic analysis of fetal acetaminophen exposure in pregnancy vs drug levels in neonates, with the goal of making an expert recommendation regarding its safety."	6.72	Acetaminophen in late pregnancy and potential for in utero closure of the ductus arteriosus-a pharmacokinetic evaluation and critical review of the literature. ( de Vrijer, B; Eastabrook, G; Garcia-Bournissen, F; Hutson, JR; Lurie, A, 2021)
"A high dose of oral ibuprofen was associated with a higher likelihood of hemodynamically significant PDA closure vs standard doses of intravenous ibuprofen or intravenous indomethacin; placebo or no treatment did not significantly change the likelihood of mortality, necrotizing enterocolitis, or intraventricular hemorrhage."	4.98	Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis. ( Florez, ID; Mbuagbaw, L; Mitra, S; Sadeghirad, B; Tamayo, ME; Thabane, L; Vanniyasingam, T; Veroniki, AA; Zea, AM; Zhang, Y, 2018)
"Paracetamol or acetaminophen (APAP) is commonly used as a first line treatment of pain and fever in pregnancy."	3.88	Paracetamol/Acetaminophen During Pregnancy Induces Prenatal Ductus Arteriosus Closure. ( Allegaert, K; Becquet, O; Bonnet, D; Lapillonne, A; Ville, Y, 2018)
"Male gender, chorioamnionitis, early sepsis, asphyxia, hemodynamic PDA, persistent hypotension, ibuprofen and paracetamol usage, and orogastric catheter administration were the main risk factors for gastric perforations in VLBW infants."	3.88	Neonatal gastric perforations in very low birth weight infants: a single center experience and review of the literature. ( Babayigit, A; Cetinkaya, M; Ozaydın, S; Sander, S, 2018)
"In very preterm infants on significant respiratory support, low dose-short course intravenous paracetamol treatment was non-inferior to a conventional dosing regime of paracetamol for closure of hsPDA in the first week of postnatal age."	3.30	Low dose paracetamol for management of patent ductus arteriosus in very preterm infants: a randomised non-inferiority trial. ( Balasubramanian, H; Bhalgat, P; Jain, V; Kabra, N; Mohan, D; Parikh, S; Sheth, K, 2023)
" Although the use of indomethacin is the standard therapy for PDA, it is sometimes not applicable because of its adverse effects, such as renal and platelet dysfunctions."	3.30	iPAPP: study protocol for a multicentre randomised controlled trial comparing safety and efficacy of intravenous paracetamol and indomethacin for the treatment of patent ductus arteriosus in preterm infants. ( Fukuoka, N; Honda, M; Kawada, K; Kikuchi, K; Mikami, M; Motojima, Y; Namba, F; Ogawa, K; Sakatani, S; Sako, M; Ueda, K, 2023)
"IV indomethacin was more effective than IV acetaminophen for treatment of hsPDAs."	3.01	A randomized trial of intravenous acetaminophen versus indomethacin for treatment of hemodynamically significant PDAs in VLBW infants. ( Davidson, JM; Ferguson, J; Ivey, E; Philip, R; Talati, AJ; Weems, MF, 2021)
" These findings have led some to suggest that acetaminophen is a safe and effective therapy for PDA closure."	3.01	Acetaminophen for the patent ductus arteriosus: has safety been adequately demonstrated? ( Jensen, EA; McCulley, DJ; Mitra, S; Wright, CJ, 2023)
"Paracetamol promotes early closure of patent ductus arteriosus (PDA), and it may affect inflammation after preterm birth."	3.01	Inflammatory biomarkers in very preterm infants during early intravenous paracetamol administration. ( Aikio, O; Hallman, M; Härkin, P; Härmä, A; Leskinen, M; Saarela, T; Salminen, A; Valkama, M, 2021)
"The optimal management of patent ductus arteriosus (PDA) remains contentious."	2.90	Early PARacetamol (EPAR) trial: a study protocol for a randomised controlled trial of early paracetamol to promote closure of the ductus arteriosus in preterm infants. ( Bolisetty, S; Lui, K; Michalowski, J; Schindler, T; Smyth, J, 2019)
"Indomethacin was more effective than acetaminophen in producing ductus constriction."	2.90	Comparative effectiveness of drugs used to constrict the patent ductus arteriosus: a secondary analysis of the PDA-TOLERATE trial (NCT01958320). ( Aucott, SW; Bulbul, A; Carey, WA; Clyman, RI; Derrick, M; Dong, L; Erdeve, O; Farooqi, A; Håkansson, S; Hassinger, DC; Hayashi, M; Heuchan, AM; Kaempf, J; Katheria, A; Kimball, A; Leone, T; Liebowitz, M; Lindqvist, J; Nelson, K; Perez, J; Sankar, M; Sauberan, J; Serize, A; Singh, J; Wickremasinghe, A; Wolf, IS, 2019)
" However, paracetamol caused fewer adverse effects."	2.82	Comparative safety and efficacy of paracetamol versus non-steroidal anti-inflammatory agents in neonates with patent ductus arteriosus: A systematic review and meta-analysis of randomized controlled trials. ( Chatziravdeli, VI; Dardiotis, E; Doxani, C; Katsaras, DN; Katsaras, GN; Mitsiakos, G; Papavasileiou, GN; Stefanidis, I; Touloupaki, M, 2022)
"Acetaminophen was used as a prophylaxis, symptomatic, targeted, and a rescue approach."	2.82	Different approaches for patent ductus arteriosus in premature infants using acetaminophen. ( Hyderi, A; Jain, A; Surak, A, 2022)
"Acetaminophen has been shown to reduce postoperative opiate burden, and may provide similar efficacy for closure of the patent ductus arteriosus (PDA) as nonsteroidal anti-inflammatory drugs (NSAIDs)."	2.82	Racing against time: leveraging preclinical models to understand pulmonary susceptibility to perinatal acetaminophen exposures. ( Dobrinskikh, E; Jensen, EA; McCulley, DJ; McKenna, S; Sherlock, LG; Sucre, JMS; Wright, CJ, 2022)
"The different management strategies for patent ductus arteriosus (PDA) in preterm infants are expectant management, surgery, or medical treatment with non-selective cyclo-oxygenase inhibitors."	2.82	Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. ( Jasani, B; Mitra, S; Shah, PS, 2022)
" Paracetamol could offer several important therapeutic advantages over current treatment options, and it could become the treatment of choice for the management of PDA, mainly due to its more favorable side effect profile."	2.82	Efficacy and safety of intravenous paracetamol in comparison to ibuprofen for the treatment of patent ductus arteriosus in preterm infants: study protocol for a randomized control trial. ( Comandini, A; Dani, C; Lipone, P; Lista, G; Mosca, F; Poggi, C; Ramenghi, L; Romagnoli, C; Rosignoli, MT; Salvatori, E; Schena, F, 2016)
"Oral ibuprofen has demonstrated good effects on symptomatic patent ductus arteriosus (PDA) but with many contraindications and potential side-effects."	2.78	Comparison of oral paracetamol versus ibuprofen in premature infants with patent ductus arteriosus: a randomized controlled trial. ( Dang, D; Wang, D; Wu, H; Zhang, C; Zhou, Q; Zhou, W, 2013)
" This article critically evaluated the literature reporting an association between acetaminophen use and in utero ductus arteriosus closure and provided a comparative pharmacokinetic analysis of fetal acetaminophen exposure in pregnancy vs drug levels in neonates, with the goal of making an expert recommendation regarding its safety."	2.72	Acetaminophen in late pregnancy and potential for in utero closure of the ductus arteriosus-a pharmacokinetic evaluation and critical review of the literature. ( de Vrijer, B; Eastabrook, G; Garcia-Bournissen, F; Hutson, JR; Lurie, A, 2021)
"Acetaminophen has emerged as an alternative to indomethacin and ibuprofen with less significant adverse effects, but there is no consensus regarding its use."	2.72	Acetaminophen Therapy for Persistent Patent Ductus Arteriosus. ( Amin, S; Manalastas, M; Nicoski, P; Weiss, MG; Zaheer, F, 2021)
" Although promising, acetaminophen treatment requires further studies regarding long-term safety as well as ideal dosing and route of administration."	2.61	Pharmacotherapy for patent ductus arteriosus closure. ( Ferguson, JM, 2019)
"The clinical management of a patent ductus arteriosus (PDA) in preterm newborns is a controversial topic, and despite nearly three decades of research, varying opinions remain."	2.53	Principles of Clinical Management of Patent Ductus Arteriosus in Extremely Preterm Neonates. ( Baral, VR; Tan, ZH, 2016)
"Management of the patent ductus arteriosus (PDA) represents an ongoing challenge in the care of extremely premature neonates."	2.53	Pharmacotherapy for Patent Ductus Arteriosus: Current Options and Outstanding Questions. ( McPherson, CC; Rostas, SE, 2016)
" On the other hand, several adverse effects have been reported with such medications, including peripheral vasoconstriction, gastrointestinal bleeding and perforation, weakened platelet aggregation, hyperbilirubinemia and renal failure."	2.52	Safety of therapeutics used in management of patent ductus arteriosus in preterm infants. ( Erdeve, O; Oncel, MY, 2015)
"Oral acetaminophen is an alternative to PDA therapy in preterm infants when indomethacin/ibuprofen is not effective or is contraindicated, and it may be considered before surgical ligation."	2.52	Acetaminophen for patent ductus arteriosus. ( Gales, BJ; Gales, MA; Le, J, 2015)
"Oral acetaminophen has gained increasing attention as an alternative pharmaceutical agent for PDA closure in premature infants, although safety concerns remain."	2.52	What is new for patent ductus arteriosus management in premature infants in 2015? ( Laughon, MM; Perez, KM, 2015)
" Dosing regimens of frusemide, and acetaminophen, and the sizes of ductus arteriosus following treatment, were evaluated."	1.62	Intravenous frusemide does not interact pharmacodynamically with acetaminophen in critically ill preterm neonates with patent ductus arteriosus. ( Al Ansari, E; Al Jufairi, M; Al Madhoob, A; Al Marzooq, R; Sridharan, K, 2021)
"Acetaminophen has been increasingly used in treating patent ductus arteriosus (PDA) in preterm neonates."	1.62	Intravenous acetaminophen (at 15 mg/kg/dose every 6 hours) in critically ill preterm neonates with patent ductus arteriosus: A prospective study. ( Al Ansari, E; Al Jufairi, M; Al Madhoob, A; Al Marzooq, R; Hasan, SJR; Hubail, Z; Sridharan, K, 2021)
" Our results suggest that the dosage used in this study (i."	1.62	Pharmacokinetics of Intravenous Paracetamol (Acetaminophen) and Ductus Arteriosus Closure After Premature Birth. ( Aikio, O; Bouazza, N; Foissac, F; Hallman, M; Roze, JC; Treluyer, JM; Urien, S, 2021)
"Late treatment with acetaminophen to avoid surgery for pPDA is associated with reduced ligation but no difference in death/NDI, supporting the safety and effectiveness of this approach."	1.62	Is late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus? ( Banihani, R; Jain, A; Jasani, B; Martins, FF; Mashally, S; Nield, LE; Weisz, DE, 2021)
"The rate of patent ductus arteriosus was significantly lower in the paracetamol-treated group compared to the control group (13."	1.56	Prophylactic low-dose paracetamol administration associated with lowered rate of patent ductus arteriosus in preterm infants - Impact on outcome and pain perception. ( Brunner, B; Geiger, R; Höck, M; Karall, T; Kiechl-Kohlendorfer, U; Rier, V; Schermer, E; Thöni, S; Trawöger, R, 2020)
"The postnatal end points included patent ductus arteriosus (PDA), primary pulmonary hypertension (PPHT), and impaired renal function."	1.51	Negligible risk of prenatal ductus arteriosus closure or fetal renal impairment after third-trimester paracetamol use: evaluation of the German Embryotox cohort. ( Beck, E; Dathe, K; Frank, J; Hultzsch, S; Meister, R; Meixner, K; Padberg, S; Schaefer, C, 2019)
" High dosage ibuprofen was associated with a faster clinical improvement and higher rate of PDA closure."	1.51	Oral ibuprofen is superior to oral paracetamol for patent ductus arteriosus in very low and extremely low birth weight infants. ( Chen, C; Li, Q; Li, Z; Lu, J; Zhu, L, 2019)
"Symptomatic patent ductus arteriosus may lead to serious complications in extremely preterm and extremely low birthweight infants and is often resistant to medication."	1.48	Intravenous paracetamol was associated with closure of the ductus arteriosus in extremely premature infants. ( Aikio, O; Hallman, M; Juujärvi, S; Saarela, T, 2018)
" Dosing of the drug is easy to control and change, hence it is possible to cancel the drug administering as soon as the required result is achieved so as to minimize any complications."	1.43	ACETAMINOPHEN ADMINISTERING IN ORDER TO OBLITERATE HEMODYNAMICALLY SIGNIFICANT PATENT DUCTUS ARTERIOSUS IN NEONATES WITH EXTREMELY LOW BIRTH WEIGHT. ( Aleksandrovich, YS; Chupaeva, OY; Khubulava, GG; Li, AG; Marchenko, SP; Melashenko, TB; Naumov, AB; Pshenisnov, KV, 2016)
"Management of patent ductus arteriosus (PDA) in preterm infants is one of the most controversial topics in neonatal medicine."	1.43	Effectiveness and safety of treatments used for the management of patent ductus arteriosus (PDA) in preterm infants: a protocol for a systematic review and network meta-analysis. ( Aune, D; Florez, ID; Mbuagbaw, L; Mitra, S; Tamayo, ME; Thabane, L; Veroniki, AA, 2016)
"In 10 of the 13 patients (76."	1.42	Intravenous paracetamol with a lower dose is also effective for the treatment of patent ductus arteriosus in pre-term infants. ( Caner, İ; Ceviz, N; Demirelli, Y; Kara, M; Olgun, H; Şahin, İO; Tekgündüz, KŞ; Yolcu, C, 2015)
"Finding the optimal pharmacological treatment of a patent ductus arteriosus (PDA) in preterm neonates remains challenging."	1.42	Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure. ( de Klerk, JC; Reiss, IK; Roofthooft, DW; Simons, SH; Tibboel, D; van Beynum, IM; van den Anker, JN; van Dijk, M, 2015)
"Ibuprofen treatment was given to 15 paracetamol-treated and to 26 control infants (p = 0."	1.40	Early paracetamol treatment associated with lowered risk of persistent ductus arteriosus in very preterm infants. ( Aikio, O; Hallman, M; Härkin, P; Saarela, T, 2014)
"Standard pharmacologic closure of the patent ductus arteriosus currently involves the administration of 1 of 2 cyclooxygenase inhibitors: either indomethacin or ibuprofen."	1.37	Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. ( Bin-Nun, A; Fink, D; Hammerman, C; Kaplan, M; Markovitch, E; Schimmel, MS, 2011)

Research

Studies (155)

Authors

Clinical Trials (16)

Trial Overview

Trial Outcomes

Duration of Gavage Feeding Assistance

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (0.65)	29.6817
2010's	94 (60.65)	24.3611
2020's	60 (38.71)	2.80

Authors	Studies
Sridharan, K	3
Al Jufairi, M	3
Al Ansari, E	3
Jasim, A	1
Eltayeb Diab, D	1
Al Marzooq, R	3
Al Madhoob, A	3
Aikio, O	8
Härmä, A	2
Härkin, P	3
Leskinen, M	3
Valkama, M	2
Saarela, T	7
Salminen, A	1
Hallman, M	8
Silahli, M	1
Gokmen, Z	1
Tekin, M	1
Bin-Nun, A	4
Abu-Omar, R	1
Shchors, I	1
Mimouni, F	1
Hammerman, C	5
Gover, A	1
Levy, PT	1
Rotschild, A	2
Golzman, M	2
Molad, M	1
Lavie-Nevo, K	2
Kessel, I	3
Wright, CJ	7
Jensen, EA	3
Cakir, U	2
Tayman, C	2
Sappler, M	2
Hammerl, M	2
Pellkofer, Y	1
Griesmaier, E	2
Höck, M	3
Janjic, T	1
Gizewski, ER	1
Kiechl-Kohlendorfer, U	3
Neubauer, V	2
Katsaras, DN	1
Katsaras, GN	1
Chatziravdeli, VI	1
Papavasileiou, GN	1
Touloupaki, M	1
Mitsiakos, G	1
Doxani, C	1
Stefanidis, I	1
Dardiotis, E	1
Surak, A	1
Jain, A	5
Hyderi, A	1
Yurttutan, S	10
McCulley, DJ	2
Sucre, JMS	1
McKenna, S	1
Sherlock, LG	2
Dobrinskikh, E	1
Raghu, K	1
Berry, MJ	1
Murphy, C	1
Bussmann, N	2
Staunton, D	1
McCallion, N	1
Franklin, O	2
El-Khuffash, A	6
Bauer-Rusek, S	1
Samra, N	1
Moore, SS	1
Arnon, S	1
Balasubramanian, H	1
Jain, V	1
Bhalgat, P	1
Parikh, S	1
Kabra, N	2
Mohan, D	1
Sheth, K	1
Shah, SD	1
Makker, K	1
Zhang, M	1
Harnett, S	1
Aziz, KB	1
Hudak, ML	1
Olowoyeye, A	3
Nnamdi-Nwosu, O	3
Manalastas, M	4
Okwundu, C	3
Deveci, MF	2
Kaya, H	2
Alagoz, M	2
Gokce, IK	2
Karakurt, C	2
Gullu, UU	2
Oncul, M	2
Ozdemir, R	3
Nagano, N	2
Katayama, D	2
Imaizumi, T	2
Hijikata, M	2
Okahashi, A	2
Tsuji, Y	2
Morioka, I	2
Jasani, B	5
Mitra, S	7
Shah, PS	7
Hatfield, T	1
Campbell-Yeo, M	1
Dorling, J	1
Johnston, BC	1
Namba, F	1
Honda, M	1
Sakatani, S	1
Motojima, Y	1
Kikuchi, K	1
Sako, M	1
Ogawa, K	1
Mikami, M	1
Kawada, K	1
Fukuoka, N	1
Ueda, K	1
de Boode, WP	1
Weisz, DE	5
Al-Shaibi, S	1
Abushanab, D	1
Abounahia, F	1
Awaisu, A	1
Al-Badriyeh, D	1
Ndayisaba, JP	1
Schreiner, C	1
Pupp-Peglow, U	1
Zhong, B	1
Tan, K	2
Razak, A	3
Sackett, V	1
Machipisa, C	1
Zhou, L	1
Samiee-Zafarghandy, S	1
Sehgal, A	2
Hunt, RW	1
Pharande, P	2
Malhotra, A	1
Bai, C	1
Meng, F	1
Wu, H	3
Wu, W	1
Gillam-Krakauer, M	1
Hagadorn, JI	1
Reese, J	3
Schindler, T	2
Smyth, J	2
Bolisetty, S	2
Michalowski, J	2
Lui, K	2
Su, BH	1
Lin, HY	1
Chiu, HY	1
Tsai, ML	1
Chen, YT	1
Lu, IC	1
Martini, S	1
Aceti, A	1
Galletti, S	1
Beghetti, I	1
Faldella, G	1
Corvaglia, L	1
Ohlsson, A	4
Noureldein, M	1
Hu, K	1
Groucutt, J	1
Heaver, R	1
Gurusamy, K	1
Kumar, A	1
Gosavi, RS	1
Sundaram, V	1
Oleti, TP	1
Krishnan, A	1
Kiran, S	1
Kumar, J	2
Murki, S	1
Sundaram, M	1
Saini, SS	1
Dutta, S	1
Hills, NK	1
Clyman, R	1
Juujärvi, S	4
Davidson, JM	1
Ferguson, J	1
Ivey, E	1
Philip, R	1
Weems, MF	1
Talati, AJ	1
Tuteja, A	1
Pournami, F	1
Kolisambeevi, AA	1
Nandakumar, A	1
Prabhakar, J	1
Jain, N	1
Iacobelli, S	1
Lorrain, S	1
Gouyon, B	1
Gambacorta, S	1
Laforgia, N	1
Gouyon, JB	1
Bonsante, F	1
Vaidya, R	1
Knee, A	1
Paris, Y	1
Singh, R	1
Dani, C	3
Lista, G	2
Bianchi, S	1
Mosca, F	2
Schena, F	2
Ramenghi, L	2
Zecca, E	1
Vento, G	1
Poggi, C	3
Leonardi, V	1
Minghetti, D	1
Rosignoli, MT	2
Calisti, F	1
Comandini, A	2
Cattaneo, A	1
Lipone, P	2
Oboodi, R	1
Najib, KS	1
Amoozgar, H	2
Pourarian, S	1
Moghtaderi, M	1
Mehdizadegan, N	2
Sabzevari, F	1
Güllü, U	1
Karacaglar, NB	1
Beser, E	1
Ceran, B	1
Unsal, H	1
Mukherjee, A	1
Jadhav, V	1
Gupta, A	1
Faim, DRO	1
Tiago, JAM	1
Castelo, RJS	1
Francisco, ASS	1
Alves, RR	1
Pires, AMGS	1
Hutson, JR	1
Lurie, A	1
Eastabrook, G	1
de Vrijer, B	1
Garcia-Bournissen, F	1
Bahrami, R	1
Ezzatabadi, A	1
Mohammadi, H	1
Edraki, M	1
Hubail, Z	1
Hasan, SJR	1
Mallitt, KA	1
Singla, A	1
Zaheer, F	1
Nicoski, P	1
Weiss, MG	1
Amin, S	1
Angelis, D	1
Jagarapu, J	1
Wan-Huen, P	1
Savani, RC	1
Jaleel, M	1
Abbas, A	1
Cawsey, M	1
Allegaert, K	4
Ceulemans, M	1
van den Anker, J	2
Bouazza, N	1
Treluyer, JM	1
Foissac, F	1
Urien, S	1
Roze, JC	1
Hauben, M	1
Bai, S	1
Hung, E	1
Lobello, K	1
Tressler, C	1
Zucal, VP	1
Mashally, S	2
Banihani, R	1
Nield, LE	3
Martins, FF	3
Ratcliffe, SJ	1
Oncel, MY	7
Eras, Z	1
Uras, N	5
Canpolat, FE	2
Erdeve, O	10
Oguz, SS	2
Huang, X	1
Wang, F	1
Wang, K	1
Bardanzellu, F	2
Neroni, P	1
Dessì, A	1
Fanos, V	2
Gálvez Criado, R	1
Rodríguez Blanco, S	1
Oulego Erroz, I	1
Jiménez González, A	1
Alonso Quintela, P	1
Watson, H	1
Babayigit, A	1
Ozaydın, S	1
Cetinkaya, M	1
Sander, S	1
Sallmon, H	2
Koehne, P	2
Al-Lawama, M	1
Alammori, I	1
Abdelghani, T	1
Badran, E	1
Cianchi, I	1
Corsini, I	1
Vangi, V	1
Pratesi, S	1
Lewis, TR	1
Shelton, EL	3
Van Driest, SL	1
Kannankeril, PJ	1
Fink, D	2
Mimouni, FB	1
Algur, N	1
Florez, ID	2
Tamayo, ME	2
Mbuagbaw, L	2
Vanniyasingam, T	1
Veroniki, AA	2
Zea, AM	1
Zhang, Y	1
Sadeghirad, B	1
Thabane, L	2
El-Farrash, RA	1
El Shimy, MS	1
El-Sakka, AS	1
Ahmed, MG	1
Abdel-Moez, DG	1
Hochwald, O	1
Mainzer, G	1
Borenstein-Levin, L	1
Jubran, H	1
Dinur, G	1
Zucker, M	1
Mor, M	1
Khoury, A	1
Kugelman, A	1
Stremming, JE	1
Brown, LD	1
Singh, GK	1
Nichols, CG	1
Becquet, O	1
Bonnet, D	1
Ville, Y	1
Lapillonne, A	1
Aleksandrovich, YS	1
Khubulava, GG	1
Chupaeva, OY	1
Naumov, AB	1
Marchenko, SP	1
Melashenko, TB	1
Pshenisnov, KV	1
Li, AG	1
Cuzzolin, L	1
McNamara, PJ	5
Jegatheeswaran, A	1
Karamlou, T	1
Perrier, SL	1
Konstantinov, IE	1
Kluckow, M	1
Carlisle, H	1
Broom, M	1
Woods, P	1
Jeffery, M	1
Desai, D	1
Chen, Y	1
Evans, N	1
Kallankari, H	1
Pätsi, P	1
Clyman, RI	2
Liebowitz, M	2
Kaempf, J	2
Bulbul, A	2
Håkansson, S	2
Lindqvist, J	2
Farooqi, A	2
Katheria, A	2
Sauberan, J	2
Singh, J	2
Nelson, K	2
Wickremasinghe, A	2
Dong, L	2
Hassinger, DC	2
Aucott, SW	2
Hayashi, M	2
Heuchan, AM	2
Carey, WA	2
Derrick, M	2
Fernandez, E	1
Sankar, M	2
Leone, T	2
Perez, J	2
Serize, A	2
Ferguson, JM	1
Yadav, A	1
Wolf, IS	1
Kimball, A	1
Karabulut, B	1
Paytoncu, S	1
Lei, C	1
Liu, H	1
Wang, H	1
Liu, C	1
Dathe, K	1
Frank, J	1
Padberg, S	1
Hultzsch, S	1
Meixner, K	1
Beck, E	1
Meister, R	1
Schaefer, C	1
Brunner, B	1
Rier, V	1
Thöni, S	1
Trawöger, R	1
Geiger, R	1
Schermer, E	1
Karall, T	1
Lu, J	1
Li, Q	1
Zhu, L	1
Chen, C	1
Li, Z	1
Tekgunduz, KS	3
Ceviz, N	2
Demirelli, Y	2
Olgun, H	2
Caner, I	2
Sahin, IO	2
Yolcu, C	2
Anderson, B	1
Simons, S	2
van Overmeire, B	1
Mazer-Amirshahi, M	1
Enriquez, DS	1
Brener, P	1
Alan, S	2
Kahvecioglu, D	1
Atasay, B	1
Arsan, S	1
Roofthooft, DW	2
van Beynum, IM	2
Helbing, WA	1
Reiss, IK	2
Simons, SH	2
Ozdemir, OM	1
Doğan, M	2
Küçüktaşçı, K	1
Ergin, H	1
Sahin, O	1
Dang, D	1
Wang, D	1
Zhang, C	1
Zhou, W	1
Zhou, Q	1
Altug, N	4
Dilmen, U	4
Waisman, D	1
Lorber, A	1
Terrin, G	2
Conte, F	2
Scipione, A	2
Bacchio, E	1
Conti, MG	1
Ferro, R	1
Ventriglia, F	1
De Curtis, M	2
Nadir, E	2
Kassem, E	1
Foldi, S	1
Hochberg, A	1
Feldman, M	1
Corcoran, D	1
Hooper, CW	1
Brown, N	1
Poole, SD	1
Milne, GL	1
DeMauro, SB	1
Ho, CH	1
Galiza, G	1
Ebrahimi, M	1
Uzunyan, MY	1
Kara, M	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Long Term Follow-up of the TREOCAPA (Prophylactic TREatment Of the duCtus Arteriosus in Preterm Infants by Acetaminophen) Study (TREOCAPA-LT)[NCT06064825]		500 participants (Anticipated)	Observational	2023-11-30	Not yet recruiting
Efficacy and Safety of Paracetamol in Comparison to Ibuprofen for Patent Ductus Arteriosus Treatment in Preterm Infants: A Randomized, Open Label, Comparator-controlled, Prospective Study[NCT02422966]	Phase 2	110 participants (Actual)	Interventional	2015-12-31	Completed
Comparison of The Effect of Continuous and Standard Intermittent Boluses Paracetamol Infusion on Patent Ductus Arteriosus[NCT04469413]		138 participants (Actual)	Observational	2019-01-01	Completed
Oral Paracetamol Versus Oral Ibuprofen Treatment[NCT01536158]	Phase 4	80 participants (Actual)	Interventional	2012-02-29	Completed
Extremely Low Gestational Age Infants' Paracetamol Study: a Randomized Trial[NCT03641209]	Phase 1/Phase 2	40 participants (Actual)	Interventional	2018-09-03	Active, not recruiting
Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus Arteriosus of Preterm Infants - Randomised, Placebo-controlled Multicentre Trial[NCT03648437]	Phase 1	60 participants (Anticipated)	Interventional	2018-09-03	Recruiting
Comparison Between the Effect of Oral Paracetamol Versus Oral Ibuprofen in the Treatment of Patent Ductus Arteriosus in Preterm and Low Birth Weight Infants[NCT03265782]	Phase 4	30 participants (Actual)	Interventional	2015-06-30	Active, not recruiting
Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus in Preterm infants-a Multicenter Trial[NCT01958320]	Phase 2	202 participants (Actual)	Interventional	2013-12-31	Completed
Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus in Premature Infants: A Pilot Study[NCT03103022]	Phase 1	20 participants (Actual)	Interventional	2017-06-12	Completed
Paracetamol Versus Ibuprofen in Premature Infants With Hemodynamically Significant Patent Ductus Arteriosus: a Randomized Clinical Trial[NCT04037514]	Phase 3	300 participants (Anticipated)	Interventional	2017-07-07	Recruiting
Comparison of the Efficacy of IV Acetaminophen Versus IV Indomethacin in Treatment of Hemodynamically Significant PDA in VLBW Infants[NCT03537144]	Phase 3	37 participants (Actual)	Interventional	2016-06-30	Terminated (stopped due to Difficulty enrolling patients)
Treatment of a PDA With Acetaminophen in Preterm Neonates: Exploring Various Indications[NCT03289390]		11 participants (Actual)	Observational	2017-08-01	Completed
TIME TO RE-EVALUATE THE KINDER GENTLER APPROACH TO PATENT DUCTUS ARTERIOSUS (PDA) IN THE PRETERM NEONATE[NCT02819414]	Phase 2	80 participants (Anticipated)	Interventional	2016-06-30	Active, not recruiting
The Preterm Infants' Paracetamol Study[NCT01938261]	Phase 2	120 participants (Anticipated)	Interventional	2013-08-31	Recruiting
Paracetamol Versus Ibuprofen for Patent Ductus Arteriosus Closure in Preterm Infants. A Prospective, Randomized, Controlled, Double Blind, Multicenter Clinical Trial.[NCT02056223]	Phase 2/Phase 3	120 participants (Anticipated)	Interventional	2017-01-09	Suspended (stopped due to We enrolled only 53 patients)
Paracetamol (Acetaminophen) for Closure of PDA in Preterm Infants[NCT01755728]	Phase 3	19 participants (Actual)	Interventional	2013-01-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

duration of gavage feeding assistance (NCT01958320)
Timeframe: up to 20 weeks of age

Incidence of Bacteremia

Intervention	days (Median)
Early Treatment	76
Conservative Treatment	80

incidence of bacteremia (NCT01958320)
Timeframe: through hospital discharge (approximately 6 months unless death occurs first)

Incidence of Bronchopulmonary Dysplasia or Death

Intervention	Participants (Count of Participants)
Early Treatment	31
Conservative Treatment	21

incidence of bronchopulmonary dysplasia or death (NCT01958320)
Timeframe: determined between 36-37 weeks corrected age

Incidence of Death

Intervention	Participants (Count of Participants)
Early Treatment	60
Conservative Treatment	56

incidence of death (NCT01958320)
Timeframe: through hospital discharge (approximately 6 months unless death occurs first)

Incidence of Necrotizing Enterocolitis or Spontaneous Perforation

Intervention	Participants (Count of Participants)
Early Treatment	20
Conservative Treatment	10

incidence of necrotizing enterocolitis or spontaneous perforation (NCT01958320)
Timeframe: through hospital discharge (approximately 6 months unless death occurs first)

Incidence of Pulmonary Hemorrhage

Intervention	Participants (Count of Participants)
Early Treatment	17
Conservative Treatment	19

incidence of pulmonary hemorrhage (NCT01958320)
Timeframe: through hospital discharge (approximately 6 months unless death occurs first)

Number of Infants Receiving ≥ 14 Days of Diuretic Treatment

Intervention	Participants (Count of Participants)
Early Treatment	2
Conservative Treatment	2

number of infants receiving ≥ 14 days of diuretic treatment (NCT01958320)
Timeframe: through hospital discharge (approximately 6 months unless death occurs first)

Number of Infants Who Received Dopamine for ≥3 Days

Intervention	Participants (Count of Participants)
Early Treatment	36
Conservative Treatment	45

number of infants who received dopamine for ≥3 days (NCT01958320)
Timeframe: through hospital discharge (approximately 6 months unless death occurs first)

Number of Infants Who Undergo in Hospital PDA Ligations or Who Have an Open Ductus at the Time of Discharge (That Need Future Outpatient Cardiology Follow-up Visits)

Intervention	Participants (Count of Participants)
Early Treatment	14
Conservative Treatment	25

Number of infants who undergo in hospital PDA ligations or who have an open ductus at the time of discharge (that need future outpatient cardiology follow-up visits) (NCT01958320)
Timeframe: through hospital discharge (approximately 6 months unless death occurs first)

the Average Daily Weight Gain

the Incidence of Persistent Moderate-to-large PDA Shunt 10 Days After Enrollment

Intervention	Participants (Count of Participants)
Early Treatment	33
Conservative Treatment	38

Intervention	gm/kg/day (Mean)
Early Treatment	22.5
Conservative Treatment	22.8

"the incidence of persistent moderate-to-large PDA shunt 10 days after enrollment The echocardiographic studies included two dimensional imaging, M-mode, color flow mapping and Doppler interrogation as previously described. A moderate-to-large PDA was defined by a ductus internal diameter ≥ 1.5mm (or PDA:left pulmonary artery diameter ratio ≥0.5) and one or more of the following echocardiographic criteria: a) left atrium-to-aortic root (LA/Ao) ratio ≥1.6, b) ductus flow velocity ≤2.5m/sec or mean pressure gradient across the ductus ≤8mm, c) left pulmonary artery diastolic flow velocity > 0.2 m/sec, and/or d) reversed diastolic flow in the descending aorta. Ductus that failed to meet these criteria were considered to be constricted (small or closed) and not eligible for enrollment or treatment." (NCT01958320)
Timeframe: 10 days after enrollment

the Incidence of Rescue Treatment Eligibility Criteria Met

Intervention	Participants (Count of Participants)
Early Treatment	43
Conservative Treatment	78

"Infants were eligible for rescue PDA drug treatment if they met one or more of the following prespecified Rescue criteria: 1) Inotrope-dependent hypotension for at least 3 days. 2) Oliguria that persisted for at least 2 days with no obvious cause, other than the moderate PDA, to explain the condition. 3) Requirement for gavage feedings beyond 35 weeks corrected age due to increased work of breathing. 4) Respiratory support needed after the following postnatal ages that surpassed specific minimal ventilation and FiO2 requirements: >15 days (if still required intubation and FiO2 >0.30), >20 days (if still required intubation and FiO2 ≤0.30; or still required Nasal CPAP or Nasal ventilation and FiO2 >0.30), >30 days (if still required Nasal CPAP or Nasal ventilation and FiO2 0.25-0.30), and >45 days (if still required Nasal CPAP or Nasal ventilation and FiO2 <0.25)." (NCT01958320)
Timeframe: through hospital discharge (approximately 6 months unless death occurs first)

Article	Year
Comparative safety and efficacy of paracetamol versus non-steroidal anti-inflammatory agents in neonates with patent ductus arteriosus: A systematic review and meta-analysis of randomized controlled trials. British journal of clinical pharmacology, 2022, Volume: 88, Issue:7 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Humans; Ibuprofen	2022
Different approaches for patent ductus arteriosus in premature infants using acetaminophen. World journal of pediatrics : WJP, 2022, Volume: 18, Issue:4 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Infant; Infant, Low Birth Weight; Infant, Newborn;	2022
Racing against time: leveraging preclinical models to understand pulmonary susceptibility to perinatal acetaminophen exposures. American journal of physiology. Lung cellular and molecular physiology, 2022, 07-01, Volume: 323, Issue:1 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Female; Humans; I	2022
Dual medication therapy (acetaminophen and ibuprofen) for the management of patent ductus arteriosus in preterm infants: a systematic review and meta-analysis. Journal of perinatology : official journal of the California Perinatal Association, 2022, Volume: 42, Issue:12 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Low Birth Weight;	2022
A Network Meta-Analysis of Intravenous Versus Oral Acetaminophen for Patent Ductus Arteriosus. Pediatric cardiology, 2023, Volume: 44, Issue:4 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Low Birth Weight;	2023
A Network Meta-Analysis of Intravenous Versus Oral Acetaminophen for Patent Ductus Arteriosus. Pediatric cardiology, 2023, Volume: 44, Issue:4 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Low Birth Weight;	2023
A Network Meta-Analysis of Intravenous Versus Oral Acetaminophen for Patent Ductus Arteriosus. Pediatric cardiology, 2023, Volume: 44, Issue:4 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Low Birth Weight;	2023
A Network Meta-Analysis of Intravenous Versus Oral Acetaminophen for Patent Ductus Arteriosus. Pediatric cardiology, 2023, Volume: 44, Issue:4 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Low Birth Weight;	2023
A Network Meta-Analysis of Intravenous Versus Oral Acetaminophen for Patent Ductus Arteriosus. Pediatric cardiology, 2023, Volume: 44, Issue:4 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Low Birth Weight;	2023
A Network Meta-Analysis of Intravenous Versus Oral Acetaminophen for Patent Ductus Arteriosus. Pediatric cardiology, 2023, Volume: 44, Issue:4 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Low Birth Weight;	2023
A Network Meta-Analysis of Intravenous Versus Oral Acetaminophen for Patent Ductus Arteriosus. Pediatric cardiology, 2023, Volume: 44, Issue:4 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Low Birth Weight;	2023
A Network Meta-Analysis of Intravenous Versus Oral Acetaminophen for Patent Ductus Arteriosus. Pediatric cardiology, 2023, Volume: 44, Issue:4 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Low Birth Weight;	2023
A Network Meta-Analysis of Intravenous Versus Oral Acetaminophen for Patent Ductus Arteriosus. Pediatric cardiology, 2023, Volume: 44, Issue:4 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Low Birth Weight;	2023
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. The Cochrane database of systematic reviews, 2022, 12-15, Volume: 12 Topics: Acetaminophen; Drug Therapy, Combination; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin	2022
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. The Cochrane database of systematic reviews, 2022, 12-15, Volume: 12 Topics: Acetaminophen; Drug Therapy, Combination; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin	2022
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. The Cochrane database of systematic reviews, 2022, 12-15, Volume: 12 Topics: Acetaminophen; Drug Therapy, Combination; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin	2022
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. The Cochrane database of systematic reviews, 2022, 12-15, Volume: 12 Topics: Acetaminophen; Drug Therapy, Combination; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin	2022
Interventions for patent ductus arteriosus (PDA) in preterm infants: an overview of Cochrane Systematic Reviews. The Cochrane database of systematic reviews, 2023, 04-11, Volume: 4 Topics: Acetaminophen; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin	2023
Acetaminophen for the patent ductus arteriosus: has safety been adequately demonstrated? Journal of perinatology : official journal of the California Perinatal Association, 2023, Volume: 43, Issue:10 Topics: Acetaminophen; Cytochrome P-450 CYP2E1; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin;	2023
Therapeutic strategy of patent ductus arteriosus in extremely preterm infants. Pediatrics and neonatology, 2020, Volume: 61, Issue:2 Topics: Acetaminophen; Ductus Arteriosus, Patent; Echocardiography; Humans; Indomethacin; Infant, Extremely	2020
To Feed or Not to Feed: A Critical Overview of Enteral Feeding Management and Gastrointestinal Complications in Preterm Neonates with a Patent Ductus Arteriosus. Nutrients, 2019, Dec-27, Volume: 12, Issue:1 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Ductus Arteriosus	2019
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. The Cochrane database of systematic reviews, 2020, 01-27, Volume: 1 Topics: Acetaminophen; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin	2020
Acetaminophen in late pregnancy and potential for in utero closure of the ductus arteriosus-a pharmacokinetic evaluation and critical review of the literature. American journal of obstetrics & gynecology MFM, 2021, Volume: 3, Issue:1 Topics: Acetaminophen; Ductus Arteriosus; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn	2021
Acetaminophen Therapy for Persistent Patent Ductus Arteriosus. NeoReviews, 2021, Volume: 22, Issue:5 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Extremely Prematu	2021
Maternal paracetamol intake and fetal ductus arteriosus closure: adding pieces to the scenery. European journal of clinical pharmacology, 2021, Volume: 77, Issue:12 Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Female; Humans; Infant, Newborn;	2021
Paracetamol versus ibuprofen for the treatment of patent ductus arteriosus in preterm neonates: a meta-analysis of randomized controlled trials. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2018, Volume: 31, Issue:16 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Ibuprofen; Infant, Newborn; Infant, Premat	2018
Paracetamol in Patent Ductus Arteriosus Treatment: Efficacious and Safe? BioMed research international, 2017, Volume: 2017 Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Anti-Inflammatory Agents, Non-Ster	2017
Genetics of the patent ductus arteriosus (PDA) and pharmacogenetics of PDA treatment. Seminars in fetal & neonatal medicine, 2018, Volume: 23, Issue:4 Topics: Acetaminophen; Animals; Disease Models, Animal; Ductus Arteriosus, Patent; Genetic Predisposition to	2018
Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis. JAMA, 2018, 03-27, Volume: 319, Issue:12 Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Bayes Theorem; Cerebral Hemorrhage	2018
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. The Cochrane database of systematic reviews, 2018, 04-06, Volume: 4 Topics: Acetaminophen; Administration, Oral; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Inf	2018
Novel drug targets for ductus arteriosus manipulation: Looking beyond prostaglandins. Seminars in perinatology, 2018, Volume: 42, Issue:4 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus; Ductus Arteriosu	2018
The dark side of ibuprofen in the treatment of patent ductus arteriosus: could paracetamol be the solution? Expert opinion on drug metabolism & toxicology, 2018, Volume: 14, Issue:8 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Rela	2018
Evidence-based use of acetaminophen for hemodynamically significant ductus arteriosus in preterm infants. Seminars in perinatology, 2018, Volume: 42, Issue:4 Topics: Acetaminophen; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Evidence-Based Medicine; Hemody	2018
Pharmacotherapy for patent ductus arteriosus closure. Congenital heart disease, 2019, Volume: 14, Issue:1 Topics: Acetaminophen; Administration, Oral; Antipyretics; Cyclooxygenase Inhibitors; Ductus Arteriosus, Pat	2019
Paracetamol to induce ductus arteriosus closure: is it valid? Archives of disease in childhood, 2013, Volume: 98, Issue:6 Topics: Acetaminophen; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Ductus Arteriosus, Patent	2013
Safety of therapeutics used in management of patent ductus arteriosus in preterm infants. Current drug safety, 2015, Volume: 10, Issue:2 Topics: Acetaminophen; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Female; Humans; Ibuprofen; Indo	2015
Acetaminophen for patent ductus arteriosus. The Annals of pharmacotherapy, 2015, Volume: 49, Issue:2 Topics: Acetaminophen; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Infant, Newborn; Infant	2015
What is new for patent ductus arteriosus management in premature infants in 2015? Current opinion in pediatrics, 2015, Volume: 27, Issue:2 Topics: Acetaminophen; Analgesics, Non-Narcotic; Cardiac Catheterization; Contraindications; Ductus Arterios	2015
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low-birth-weight infants. The Cochrane database of systematic reviews, 2015, Mar-11, Issue:3 Topics: Acetaminophen; Administration, Oral; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Inf	2015
Paracetamol for the treatment of patent ductus arteriosus in preterm neonates: a systematic review and meta-analysis. Archives of disease in childhood. Fetal and neonatal edition, 2016, Volume: 101, Issue:2 Topics: Acetaminophen; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Newb	2016
Paracetamol for the treatment of patent ductus arteriosus in preterm neonates: a systematic review and meta-analysis. Archives of disease in childhood. Fetal and neonatal edition, 2016, Volume: 101, Issue:2 Topics: Acetaminophen; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Newb	2016
Paracetamol for the treatment of patent ductus arteriosus in preterm neonates: a systematic review and meta-analysis. Archives of disease in childhood. Fetal and neonatal edition, 2016, Volume: 101, Issue:2 Topics: Acetaminophen; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Newb	2016
Paracetamol for the treatment of patent ductus arteriosus in preterm neonates: a systematic review and meta-analysis. Archives of disease in childhood. Fetal and neonatal edition, 2016, Volume: 101, Issue:2 Topics: Acetaminophen; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Newb	2016
[Paracetamol (acetaminophen) use in neonatology: a (re)appreciation of an old drug]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2015, Volume: 22, Issue:10 Topics: Acetaminophen; Analgesics, Non-Narcotic; Cyclooxygenase 2 Inhibitors; Ductus Arteriosus, Patent; Fem	2015
Recent Advances in the Treatment of Preterm Newborn Infants with Patent Ductus Arteriosus. Clinics in perinatology, 2016, Volume: 43, Issue:1 Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Anti-Inflammatory Agents, Non-Ster	2016
Principles of Clinical Management of Patent Ductus Arteriosus in Extremely Preterm Neonates. Current pediatric reviews, 2016, Volume: 12, Issue:2 Topics: Acetaminophen; Anterior Cerebral Artery; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Echoc	2016
Pharmacotherapy for Patent Ductus Arteriosus: Current Options and Outstanding Questions. Current pediatric reviews, 2016, Volume: 12, Issue:2 Topics: Acetaminophen; Cost-Benefit Analysis; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans;	2016
Managing the patent ductus arteriosus in the premature neonate: a new look at what we thought we knew. Seminars in perinatology, 2012, Volume: 36, Issue:2 Topics: Acetaminophen; Biomarkers; Dose-Response Relationship, Drug; Ductus Arteriosus, Patent; Echocardiogr	2012

Article	Year
Inflammatory biomarkers in very preterm infants during early intravenous paracetamol administration. Early human development, 2021, Volume: 161 Topics: Acetaminophen; Administration, Intravenous; Biomarkers; Ductus Arteriosus, Patent; Humans; Infant, N	2021
Low dose paracetamol for management of patent ductus arteriosus in very preterm infants: a randomised non-inferiority trial. Archives of disease in childhood. Fetal and neonatal edition, 2023, Volume: 108, Issue:2 Topics: Acetaminophen; Double-Blind Method; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Newborn; I	2023
Combined (dual) drug therapy for the treatment of patent ductus arteriosus: last approach prior to ligation. Cardiology in the young, 2023, Volume: 33, Issue:8 Topics: Acetaminophen; Drug Therapy, Combination; Ductus Arteriosus, Patent; Echocardiography; Female; Human	2023
Combined (dual) drug therapy for the treatment of patent ductus arteriosus: last approach prior to ligation. Cardiology in the young, 2023, Volume: 33, Issue:8 Topics: Acetaminophen; Drug Therapy, Combination; Ductus Arteriosus, Patent; Echocardiography; Female; Human	2023
Combined (dual) drug therapy for the treatment of patent ductus arteriosus: last approach prior to ligation. Cardiology in the young, 2023, Volume: 33, Issue:8 Topics: Acetaminophen; Drug Therapy, Combination; Ductus Arteriosus, Patent; Echocardiography; Female; Human	2023
Combined (dual) drug therapy for the treatment of patent ductus arteriosus: last approach prior to ligation. Cardiology in the young, 2023, Volume: 33, Issue:8 Topics: Acetaminophen; Drug Therapy, Combination; Ductus Arteriosus, Patent; Echocardiography; Female; Human	2023
iPAPP: study protocol for a multicentre randomised controlled trial comparing safety and efficacy of intravenous paracetamol and indomethacin for the treatment of patent ductus arteriosus in preterm infants. BMJ open, 2023, 03-23, Volume: 13, Issue:3 Topics: Acetaminophen; Administration, Intravenous; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethac	2023
Effect of fetal lung maturation on the efficacy of acetaminophen for premature infants with patent ductus arteriosus. Medicine, 2023, Jun-16, Volume: 102, Issue:24 Topics: Acetaminophen; Bronchopulmonary Dysplasia; Cerebral Hemorrhage; Ductus Arteriosus, Patent; Enterocol	2023
Early PARacetamol (EPAR) trial: a study protocol for a randomised controlled trial of early paracetamol to promote closure of the ductus arteriosus in preterm infants. BMJ open, 2019, 10-30, Volume: 9, Issue:10 Topics: Acetaminophen; Administration, Intravenous; Clinical Trials, Phase II as Topic; Double-Blind Method;	2019
Oral Paracetamol vs Oral Ibuprofen in Patent Ductus Arteriosus: A Randomized, Controlled, Noninferiority Trial. The Journal of pediatrics, 2020, Volume: 222 Topics: Acetaminophen; Administration, Oral; Double-Blind Method; Ductus Arteriosus, Patent; Female; Humans;	2020
A randomized trial of intravenous acetaminophen versus indomethacin for treatment of hemodynamically significant PDAs in VLBW infants. Journal of perinatology : official journal of the California Perinatal Association, 2021, Volume: 41, Issue:1 Topics: Acetaminophen; Administration, Oral; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Inf	2021
Intravenous paracetamol in comparison with ibuprofen for the treatment of patent ductus arteriosus in preterm infants: a randomized controlled trial. European journal of pediatrics, 2021, Volume: 180, Issue:3 Topics: Acetaminophen; Ductus Arteriosus, Patent; Gestational Age; Humans; Ibuprofen; Infant; Infant, Newbor	2021
Positive tendency toward synchronous use of acetaminophen and ibuprofen in treating patients with patent ductus arteriosus. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2020, Volume: 48, Issue:6 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Dinopr	2020
Trial of paracetamol for premature newborns: five-year follow-up. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022, Volume: 35, Issue:25 Topics: Acetaminophen; Child; Ductus Arteriosus, Patent; Follow-Up Studies; Humans; Infant; Infant, Newborn;	2022
Early PARacetamol (EPAR) Trial: A Randomized Controlled Trial of Early Paracetamol to Promote Closure of the Ductus Arteriosus in Preterm Infants. Neonatology, 2021, Volume: 118, Issue:3 Topics: Acetaminophen; Ductus Arteriosus; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Newborn; Inf	2021
Neurodevelopmental Outcomes of Preterm Infants Treated with Oral Paracetamol Versus Ibuprofen for Patent Ductus Arteriosus. American journal of perinatology, 2017, Volume: 34, Issue:12 Topics: Acetaminophen; Administration, Oral; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Female; F	2017
Efficacy and safety of oral paracetamol versus oral ibuprofen for closure of patent ductus arteriosus in preterm infants: a randomized controlled trial. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2019, Volume: 32, Issue:21 Topics: Acetaminophen; Administration, Oral; Case-Control Studies; Double-Blind Method; Ductus Arteriosus, P	2019
Adding Paracetamol to Ibuprofen for the Treatment of Patent Ductus Arteriosus in Preterm Infants: A Double-Blind, Randomized, Placebo-Controlled Pilot Study. American journal of perinatology, 2018, Volume: 35, Issue:13 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Metho	2018
A pilot randomised blinded placebo-controlled trial of paracetamol for later treatment of a patent ductus arteriosus. Journal of perinatology : official journal of the California Perinatal Association, 2019, Volume: 39, Issue:1 Topics: Acetaminophen; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; D	2019
Follow-up study of the early, randomised paracetamol trial to preterm infants, found no adverse reactions at the two-years corrected age. Acta paediatrica (Oslo, Norway : 1992), 2019, Volume: 108, Issue:3 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Child, Preschool; Double-Blind	2019
PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-to-Large Patent Ductus Arteriosus at 1 Week of Age. The Journal of pediatrics, 2019, Volume: 205 Topics: Acetaminophen; Conservative Treatment; Continuous Positive Airway Pressure; Cyclooxygenase Inhibitor	2019
PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-to-Large Patent Ductus Arteriosus at 1 Week of Age. The Journal of pediatrics, 2019, Volume: 205 Topics: Acetaminophen; Conservative Treatment; Continuous Positive Airway Pressure; Cyclooxygenase Inhibitor	2019
PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-to-Large Patent Ductus Arteriosus at 1 Week of Age. The Journal of pediatrics, 2019, Volume: 205 Topics: Acetaminophen; Conservative Treatment; Continuous Positive Airway Pressure; Cyclooxygenase Inhibitor	2019
PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-to-Large Patent Ductus Arteriosus at 1 Week of Age. The Journal of pediatrics, 2019, Volume: 205 Topics: Acetaminophen; Conservative Treatment; Continuous Positive Airway Pressure; Cyclooxygenase Inhibitor	2019
Comparative effectiveness of drugs used to constrict the patent ductus arteriosus: a secondary analysis of the PDA-TOLERATE trial (NCT01958320). Journal of perinatology : official journal of the California Perinatal Association, 2019, Volume: 39, Issue:5 Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Conservative Treatment; Ductus Art	2019
Comparison of oral paracetamol versus ibuprofen in premature infants with patent ductus arteriosus: a randomized controlled trial. PloS one, 2013, Volume: 8, Issue:11 Topics: Acetaminophen; Administration, Oral; Ductus Arteriosus, Patent; Female; Gestational Age; Heart; Huma	2013
Comparison of oral paracetamol versus ibuprofen in premature infants with patent ductus arteriosus: a randomized controlled trial. PloS one, 2013, Volume: 8, Issue:11 Topics: Acetaminophen; Administration, Oral; Ductus Arteriosus, Patent; Female; Gestational Age; Heart; Huma	2013
Comparison of oral paracetamol versus ibuprofen in premature infants with patent ductus arteriosus: a randomized controlled trial. PloS one, 2013, Volume: 8, Issue:11 Topics: Acetaminophen; Administration, Oral; Ductus Arteriosus, Patent; Female; Gestational Age; Heart; Huma	2013
Comparison of oral paracetamol versus ibuprofen in premature infants with patent ductus arteriosus: a randomized controlled trial. PloS one, 2013, Volume: 8, Issue:11 Topics: Acetaminophen; Administration, Oral; Ductus Arteriosus, Patent; Female; Gestational Age; Heart; Huma	2013
Comparison of oral paracetamol versus ibuprofen in premature infants with patent ductus arteriosus: a randomized controlled trial. PloS one, 2013, Volume: 8, Issue:11 Topics: Acetaminophen; Administration, Oral; Ductus Arteriosus, Patent; Female; Gestational Age; Heart; Huma	2013
Comparison of oral paracetamol versus ibuprofen in premature infants with patent ductus arteriosus: a randomized controlled trial. PloS one, 2013, Volume: 8, Issue:11 Topics: Acetaminophen; Administration, Oral; Ductus Arteriosus, Patent; Female; Gestational Age; Heart; Huma	2013
Comparison of oral paracetamol versus ibuprofen in premature infants with patent ductus arteriosus: a randomized controlled trial. PloS one, 2013, Volume: 8, Issue:11 Topics: Acetaminophen; Administration, Oral; Ductus Arteriosus, Patent; Female; Gestational Age; Heart; Huma	2013
Comparison of oral paracetamol versus ibuprofen in premature infants with patent ductus arteriosus: a randomized controlled trial. PloS one, 2013, Volume: 8, Issue:11 Topics: Acetaminophen; Administration, Oral; Ductus Arteriosus, Patent; Female; Gestational Age; Heart; Huma	2013
Comparison of oral paracetamol versus ibuprofen in premature infants with patent ductus arteriosus: a randomized controlled trial. PloS one, 2013, Volume: 8, Issue:11 Topics: Acetaminophen; Administration, Oral; Ductus Arteriosus, Patent; Female; Gestational Age; Heart; Huma	2013
Oral paracetamol versus oral ibuprofen in the management of patent ductus arteriosus in preterm infants: a randomized controlled trial. The Journal of pediatrics, 2014, Volume: 164, Issue:3 Topics: Acetaminophen; Administration, Oral; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; I	2014
Oral paracetamol versus oral ibuprofen in the management of patent ductus arteriosus in preterm infants: a randomized controlled trial. The Journal of pediatrics, 2014, Volume: 164, Issue:3 Topics: Acetaminophen; Administration, Oral; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; I	2014
Oral paracetamol versus oral ibuprofen in the management of patent ductus arteriosus in preterm infants: a randomized controlled trial. The Journal of pediatrics, 2014, Volume: 164, Issue:3 Topics: Acetaminophen; Administration, Oral; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; I	2014
Oral paracetamol versus oral ibuprofen in the management of patent ductus arteriosus in preterm infants: a randomized controlled trial. The Journal of pediatrics, 2014, Volume: 164, Issue:3 Topics: Acetaminophen; Administration, Oral; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; I	2014
Oral paracetamol versus oral ibuprofen in the management of patent ductus arteriosus in preterm infants: a randomized controlled trial. The Journal of pediatrics, 2014, Volume: 164, Issue:3 Topics: Acetaminophen; Administration, Oral; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; I	2014
Oral paracetamol versus oral ibuprofen in the management of patent ductus arteriosus in preterm infants: a randomized controlled trial. The Journal of pediatrics, 2014, Volume: 164, Issue:3 Topics: Acetaminophen; Administration, Oral; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; I	2014
Oral paracetamol versus oral ibuprofen in the management of patent ductus arteriosus in preterm infants: a randomized controlled trial. The Journal of pediatrics, 2014, Volume: 164, Issue:3 Topics: Acetaminophen; Administration, Oral; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; I	2014
Oral paracetamol versus oral ibuprofen in the management of patent ductus arteriosus in preterm infants: a randomized controlled trial. The Journal of pediatrics, 2014, Volume: 164, Issue:3 Topics: Acetaminophen; Administration, Oral; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; I	2014
Oral paracetamol versus oral ibuprofen in the management of patent ductus arteriosus in preterm infants: a randomized controlled trial. The Journal of pediatrics, 2014, Volume: 164, Issue:3 Topics: Acetaminophen; Administration, Oral; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; I	2014
Paracetamol treatment of patent ductus arteriosus in preterm infants. Journal of perinatology : official journal of the California Perinatal Association, 2014, Volume: 34, Issue:10 Topics: Acetaminophen; Administration, Oral; Dose-Response Relationship, Drug; Drug Administration Schedule;	2014
Enteral paracetamol or Intravenous Indomethacin for Closure of Patent Ductus Arteriosus in Preterm Neonates: A Randomized Controlled Trial. Indian pediatrics, 2015, Volume: 52, Issue:7 Topics: Acetaminophen; Administration, Intravenous; Adult; Ductus Arteriosus, Patent; Female; Humans; Indome	2015
Enteral paracetamol or Intravenous Indomethacin for Closure of Patent Ductus Arteriosus in Preterm Neonates: A Randomized Controlled Trial. Indian pediatrics, 2015, Volume: 52, Issue:7 Topics: Acetaminophen; Administration, Intravenous; Adult; Ductus Arteriosus, Patent; Female; Humans; Indome	2015
Enteral paracetamol or Intravenous Indomethacin for Closure of Patent Ductus Arteriosus in Preterm Neonates: A Randomized Controlled Trial. Indian pediatrics, 2015, Volume: 52, Issue:7 Topics: Acetaminophen; Administration, Intravenous; Adult; Ductus Arteriosus, Patent; Female; Humans; Indome	2015
Enteral paracetamol or Intravenous Indomethacin for Closure of Patent Ductus Arteriosus in Preterm Neonates: A Randomized Controlled Trial. Indian pediatrics, 2015, Volume: 52, Issue:7 Topics: Acetaminophen; Administration, Intravenous; Adult; Ductus Arteriosus, Patent; Female; Humans; Indome	2015
Efficacy and safety of intravenous paracetamol in comparison to ibuprofen for the treatment of patent ductus arteriosus in preterm infants: study protocol for a randomized control trial. Trials, 2016, Apr-02, Volume: 17 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Clinical Protocols	2016
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial. The Journal of pediatrics, 2016, Volume: 177 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar	2016
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial. The Journal of pediatrics, 2016, Volume: 177 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar	2016
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial. The Journal of pediatrics, 2016, Volume: 177 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar	2016
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial. The Journal of pediatrics, 2016, Volume: 177 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar	2016
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial. The Journal of pediatrics, 2016, Volume: 177 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar	2016
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial. The Journal of pediatrics, 2016, Volume: 177 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar	2016
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial. The Journal of pediatrics, 2016, Volume: 177 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar	2016
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial. The Journal of pediatrics, 2016, Volume: 177 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar	2016
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial. The Journal of pediatrics, 2016, Volume: 177 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar	2016
Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates. European journal of pediatrics, 2017, Volume: 176, Issue:2 Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Cyclooxygenase Inhibitors; Ductus Art	2017
Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates. European journal of pediatrics, 2017, Volume: 176, Issue:2 Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Cyclooxygenase Inhibitors; Ductus Art	2017
Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates. European journal of pediatrics, 2017, Volume: 176, Issue:2 Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Cyclooxygenase Inhibitors; Ductus Art	2017
Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates. European journal of pediatrics, 2017, Volume: 176, Issue:2 Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Cyclooxygenase Inhibitors; Ductus Art	2017
A different first-choice drug in the medical management of patent ductus arteriosus: oral paracetamol. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2013, Volume: 26, Issue:8 Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Humans; In	2013

Article	Year
Evaluation of urinary acetaminophen metabolites and its association with the genetic polymorphisms of the metabolising enzymes, and serum acetaminophen concentrations in preterm neonates with patent ductus arteriosus. Xenobiotica; the fate of foreign compounds in biological systems, 2021, Volume: 51, Issue:11 Topics: Acetaminophen; Administration, Intravenous; Adult; Cytochrome P-450 Enzyme System; Ductus Arteriosus	2021
Prophylactic intravenous paracetamol use in extremely premature infants for patent ductus arteriosus. Journal of basic and clinical physiology and pharmacology, 2020, Dec-14, Volume: 32, Issue:5 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Extremely Premature; Infant, Ne	2020
Does Early Neonatal Thrombocytopenia Affect Ductal Therapeutic Response to Acetaminophen in Preterm Neonates? American journal of perinatology, 2022, Volume: 29, Issue:14 Topics: Acetaminophen; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Newb	2022
Oral versus intravenous paracetamol for patent ductus arteriosus closure in preterm infants. Pediatric research, 2022, Volume: 92, Issue:4 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Newborn; Infant, Premature; Pro	2022
EBNEO Commentary: Paracetamol/acetaminophen to avoid PDA ligation: How to interpret impact on 18- to 24-month outcomes. Acta paediatrica (Oslo, Norway : 1992), 2022, Volume: 111, Issue:4 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ligation	2022
What Should be the First-line Treatment for the Closure of Hemodynamically Significant Patent Ductus Arteriosus in Premature Infants? Arquivos brasileiros de cardiologia, 2022, Volume: 118, Issue:3 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant; Infant, Low Birth Weight; Infan	2022
Prophylactic Low-Dose Paracetamol Administration for Ductal Closure and Microstructural Brain Development in Preterm Infants. Neonatology, 2022, Volume: 119, Issue:3 Topics: Acetaminophen; Brain; Diffusion Tensor Imaging; Ductus Arteriosus, Patent; Female; Gestational Age;	2022
A perspective on the potential side effects of paracetamol use in the treatment of PDA. Pediatric research, 2022, Volume: 92, Issue:6 Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Newbo	2022
Acute liver failure secondary to therapeutic paracetamol dosing in an extremely preterm neonate. BMJ case reports, 2022, May-06, Volume: 15, Issue:5 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant; Infant, Extremely Premature; In	2022
The effect of patent ductus arteriosus treatment with paracetamol on pulmonary vascular resistance. Journal of perinatology : official journal of the California Perinatal Association, 2022, Volume: 42, Issue:12 Topics: Acetaminophen; Ductus Arteriosus, Patent; Gestational Age; Humans; Infant, Newborn; Infant, Prematur	2022
Paracetamol Treatment for Patent Ductus Arteriosus, an Apparent Association with Acute Hemolysis in Three Preterm Infants: Case Series. Neonatology, 2022, Volume: 119, Issue:4 Topics: Acetaminophen; Ductus Arteriosus, Patent; Hemolysis; Humans; Ibuprofen; Infant, Newborn; Infant, Pre	2022
Fluctuations in unbound bilirubin levels during acetaminophen therapy for patent ductus arteriosus. Pediatrics international : official journal of the Japan Pediatric Society, 2023, Volume: 65, Issue:1 Topics: Acetaminophen; Bilirubin; Ductus Arteriosus, Patent; Humans; Infant, Newborn; Infant, Premature; Per	2023
Fluctuations in unbound bilirubin levels during acetaminophen therapy for patent ductus arteriosus. Pediatrics international : official journal of the Japan Pediatric Society, 2023, Volume: 65, Issue:1 Topics: Acetaminophen; Bilirubin; Ductus Arteriosus, Patent; Humans; Infant, Newborn; Infant, Premature; Per	2023
Fluctuations in unbound bilirubin levels during acetaminophen therapy for patent ductus arteriosus. Pediatrics international : official journal of the Japan Pediatric Society, 2023, Volume: 65, Issue:1 Topics: Acetaminophen; Bilirubin; Ductus Arteriosus, Patent; Humans; Infant, Newborn; Infant, Premature; Per	2023
Fluctuations in unbound bilirubin levels during acetaminophen therapy for patent ductus arteriosus. Pediatrics international : official journal of the Japan Pediatric Society, 2023, Volume: 65, Issue:1 Topics: Acetaminophen; Bilirubin; Ductus Arteriosus, Patent; Humans; Infant, Newborn; Infant, Premature; Per	2023
Evaluation of Health-Related Values and Preferences of Adults Who Were Preterm Infants and Parents of Preterm Infants Concerning Use of Prophylactic Cyclooxygenase Inhibitor Drugs. JAMA network open, 2023, 03-01, Volume: 6, Issue:3 Topics: Acetaminophen; Adult; Cerebral Hemorrhage; Child; Cross-Sectional Studies; Cyclooxygenase Inhibitors	2023
Cost-Effectiveness Analysis of Ibuprofen Versus Indomethacin or Paracetamol for the Treatment of Patent Ductus Arteriosus in Preterm Neonates. Current problems in cardiology, 2023, Volume: 48, Issue:9 Topics: Acetaminophen; Cost-Effectiveness Analysis; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Hu	2023
Prophylactic low-dose paracetamol for ductal closure and neurodevelopmental outcome in very preterm infants. Acta paediatrica (Oslo, Norway : 1992), 2023, Volume: 112, Issue:8 Topics: Acetaminophen; Child; Child, Preschool; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant; Infant	2023
Early neurodevelopmental outcomes of extreme preterm infants exposed to paracetamol: a retrospective cohort study. Pediatric research, 2023, Volume: 94, Issue:5 Topics: Acetaminophen; Birth Weight; Ductus Arteriosus, Patent; Female; Humans; Ibuprofen; Infant; Infant, N	2023
Pharmacological closure of the patent ductus arteriosus: when treatment still makes sense. Journal of perinatology : official journal of the California Perinatal Association, 2019, Volume: 39, Issue:11 Topics: Acetaminophen; Cyclooxygenase Inhibitors; Decision Making; Ductus Arteriosus, Patent; Humans; Indome	2019
Paracetamol for patent ductus arteriosus in preterm infants: a UK national survey. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022, Volume: 35, Issue:7 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant; Infant, Newborn; Infant, Premat	2022
Paracetamol (Acetaminophen) for Patent Ductus Arteriosus: Where Do We Stand? The Journal of pediatrics, 2020, Volume: 222 Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Newbo	2020
Simultaneous paracetamol may promote ibuprofen-induced closure of ductus arteriosus. European journal of clinical pharmacology, 2020, Volume: 76, Issue:8 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-	2020
Paracetamol for Patent Ductus Arteriosus Closure: High Osmolality of Enteral Form and Spontaneous Intestinal Perforation. Indian journal of pediatrics, 2020, Volume: 87, Issue:9 Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Humans; Ibuprofen; Intestinal Pe	2020
Drug exposure for PDA closure in France: a prospective, cohort-based, analysis. European journal of clinical pharmacology, 2020, Volume: 76, Issue:12 Topics: Acetaminophen; Administration, Oral; Drug Resistance; Drug Utilization; Ductus Arteriosus, Patent; F	2020
Predictors of successful patent ductus arteriosus closure with acetaminophen in preterm infants. Journal of perinatology : official journal of the California Perinatal Association, 2021, Volume: 41, Issue:5 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Indomethacin; Infant; Infant, Newborn; Infant, Pre	2021
Paracetamol for Patent Ductus Arteriosus Closure: High Osmolality of Enteral Form and Spontaneous Intestinal Perforation - Correspondence. Indian journal of pediatrics, 2021, Volume: 88, Issue:6 Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Humans; Intestinal Perforation;	2021
Comparison of the effect of continuous and standard intermittent bolus paracetamol infusion on patent ductus arteriosus. European journal of pediatrics, 2021, Volume: 180, Issue:2 Topics: Acetaminophen; Ductus Arteriosus, Patent; Gestational Age; Humans; Ibuprofen; Infant; Infant, Newbor	2021
Off-label use of paracetamol in managing patent ductus arteriosus across neonatal intensive care units in the UK. Archives of disease in childhood. Fetal and neonatal edition, 2021, Volume: 106, Issue:1 Topics: Acetaminophen; Drug Dosage Calculations; Ductus Arteriosus, Patent; Humans; Infant, Newborn; Infant,	2021
PATENT DUCTUS ARTERIOSUS CLOSURE: EXPERIENCE FROM A TERTIARY REFERRAL CENTER. Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, 2020, Volume: 39 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibuprofen; Indomethacin;	2020
Does high dose intravenous acetaminophen affect liver function for PDA closure in premature neonate? Italian journal of pediatrics, 2021, Feb-18, Volume: 47, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Ductus Arteriosus, Patent	2021
Intravenous frusemide does not interact pharmacodynamically with acetaminophen in critically ill preterm neonates with patent ductus arteriosus. European review for medical and pharmacological sciences, 2021, Volume: 25, Issue:3 Topics: Acetaminophen; Administration, Intravenous; Critical Illness; Ductus Arteriosus, Patent; Female; Fur	2021
Intravenous acetaminophen (at 15 mg/kg/dose every 6 hours) in critically ill preterm neonates with patent ductus arteriosus: A prospective study. Journal of clinical pharmacy and therapeutics, 2021, Volume: 46, Issue:4 Topics: Acetaminophen; Acute Kidney Injury; Administration, Intravenous; Birth Weight; Chemical and Drug Ind	2021
Part II. Acetaminophen and closure of ductus arteriosus in the newborns: Mechanisms of action, clinical studies, safety and efficacy. Early human development, 2021, Volume: 159 Topics: Acetaminophen; Ductus Arteriosus; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Newborn; Tre	2021
Is intravenous paracetamol as effective as ibuprofen in closing haemodynamically significant patent ductus arteriosus after the first treatment course in preterm babies? Acta paediatrica (Oslo, Norway : 1992), 2021, Volume: 110, Issue:10 Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant; Infan	2021
Pharmacokinetics of Intravenous Paracetamol (Acetaminophen) and Ductus Arteriosus Closure After Premature Birth. Clinical pharmacology and therapeutics, 2021, Volume: 110, Issue:4 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Ech	2021
Response/comments to maternal paracetamol intake and fetal ductus arteriosus closure: adding pieces to the scenery-Karel Allegaert, Michael Ceulemans, John van den Anke. European journal of clinical pharmacology, 2022, Volume: 78, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus; Ductus Arteriosus, Patent; Humans	2022
Is late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus? Journal of perinatology : official journal of the California Perinatal Association, 2021, Volume: 41, Issue:10 Topics: Acetaminophen; Ductus Arteriosus, Patent; Gestational Age; Humans; Infant; Infant, Extremely Prematu	2021
Oral paracetamol or oral ibuprofen to close the ductus arteriosus: both 'work', but do we know when to use them? Acta paediatrica (Oslo, Norway : 1992), 2017, Volume: 106, Issue:9 Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Ductus Arteriosus; Ductus Arteriosus,	2017
[Paracetamol: Useful treatment of choice for persistent arterial duct in very low weight premature newborns]. Anales de pediatria, 2018, Volume: 88, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant, Newborn; Infant, Premature; Infant	2018
Oral Paracetamol for Patent Ductus Arteriosus Rescue Closure. Pediatric cardiology, 2018, Volume: 39, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Repositioning; Ductus Arteriosus, Patent; Echocardiogr	2018
Neonatal gastric perforations in very low birth weight infants: a single center experience and review of the literature. Pediatric surgery international, 2018, Volume: 34, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Asphyxia Neonatorum; Chorioamnionitis; Ductus Arteriosus, P	2018
Intravenous paracetamol was associated with closure of the ductus arteriosus in extremely premature infants. Acta paediatrica (Oslo, Norway : 1992), 2018, Volume: 107, Issue:4 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Fem	2018
Intravenous paracetamol was associated with closure of the ductus arteriosus in extremely premature infants. Acta paediatrica (Oslo, Norway : 1992), 2018, Volume: 107, Issue:4 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Fem	2018
Intravenous paracetamol was associated with closure of the ductus arteriosus in extremely premature infants. Acta paediatrica (Oslo, Norway : 1992), 2018, Volume: 107, Issue:4 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Fem	2018
Intravenous paracetamol was associated with closure of the ductus arteriosus in extremely premature infants. Acta paediatrica (Oslo, Norway : 1992), 2018, Volume: 107, Issue:4 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Fem	2018
Further Experience with Oral Paracetamol as a Rescue Therapy for Patent Ductus Arteriosus in Preterm Infants. Pediatric cardiology, 2018, Volume: 39, Issue:2 Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Humans; Infant, Newborn; Infant,	2018
Oral paracetamol versus oral ibuprofen for treatment of patent ductus arteriosus. The Journal of international medical research, 2018, Volume: 46, Issue:2 Topics: Acetaminophen; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Pat	2018
Effect on cerebral oxygenation of paracetamol for patent ductus arteriosus in preterm infants. European journal of pediatrics, 2018, Volume: 177, Issue:4 Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Flow Velocity; Cerebrovascular Circulation; Ductus Ar	2018
Paracetamol Serum Concentrations in Neonates Treated Enterally for Ductal Closure: A Pilot Study. The Journal of pediatrics, 2018, Volume: 198 Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Humans; In	2018
Is paracetamol as effective as indomethacin or ibuprofen in closing a hemodynamically significant patent ductus arteriosus in preterm infants? Acta paediatrica (Oslo, Norway : 1992), 2018, Volume: 107, Issue:10 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Newborn; Infant,	2018
Paracetamol/Acetaminophen During Pregnancy Induces Prenatal Ductus Arteriosus Closure. Pediatrics, 2018, Volume: 142, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Female; Humans; Infant, Newborn;	2018
ACETAMINOPHEN ADMINISTERING IN ORDER TO OBLITERATE HEMODYNAMICALLY SIGNIFICANT PATENT DUCTUS ARTERIOSUS IN NEONATES WITH EXTREMELY LOW BIRTH WEIGHT. Anesteziologiia i reanimatologiia, 2016, Volume: 61, Issue:6 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Hemodynamics; Hum	2016
Paracetamol for ductal closure: Inching closer, but cautiously! The Journal of pediatrics, 2018, Volume: 198 Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Humans; Infant, Newborn; Pilot P	2018
Late oral acetaminophen versus immediate surgical ligation in preterm infants with persistent large patent ductus arteriosus. The Journal of thoracic and cardiovascular surgery, 2018, Volume: 156, Issue:5 Topics: Acetaminophen; Administration, Oral; Cardiac Surgical Procedures; Chronic Disease; Clinical Decision	2018
Patent ductus arteriosus ligation versus medical therapy: A glowing recommendation for matching. The Journal of thoracic and cardiovascular surgery, 2018, Volume: 156, Issue:5 Topics: Acetaminophen; Ductus Arteriosus, Patent; Gestational Age; Humans; Infant; Infant, Newborn; Infant,	2018
Pharmacotherapy for closure of large patent ductus arteriosus in preterm neonates: Fail once, not twice. The Journal of thoracic and cardiovascular surgery, 2018, Volume: 156, Issue:5 Topics: Acetaminophen; Ductus Arteriosus, Patent; Gestational Age; Humans; Infant; Infant, Newborn; Infant,	2018
Commentary on paracetamol in preterm infants. Acta paediatrica (Oslo, Norway : 1992), 2019, Volume: 108, Issue:3 Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Follow-Up Studies; Humans; Infan	2019
What is the Most Efficacious Pharmacological Therapy for Patent Ductus Arteriosus Closure in Premature Infants? Irish medical journal, 2018, 10-11, Volume: 111, Issue:9 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant; Infant, Newborn;	2018
Comparison of efficacy of paracetamol and ibuprofen in preterm infants. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2020, Volume: 33, Issue:16 Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant; Infan	2020
Efficacy and Safety of Oral Paracetamol vs. Oral Ibuprofen in the Treatment of Symptomatic Patent Ductus Arteriosus in Premature Infants. Paediatric drugs, 2019, Volume: 21, Issue:2 Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Gestationa	2019
Effectiveness and Renal Functions Safety of Treatments Used for Neonates with Patent Ductus Arteriosus: A Prospective Cohort Study. Medical science monitor : international medical journal of experimental and clinical research, 2019, May-17, Volume: 25 Topics: Acetaminophen; Acute Kidney Injury; China; Cohort Studies; Ductus Arteriosus, Patent; Female; Humans	2019
Negligible risk of prenatal ductus arteriosus closure or fetal renal impairment after third-trimester paracetamol use: evaluation of the German Embryotox cohort. BJOG : an international journal of obstetrics and gynaecology, 2019, Volume: 126, Issue:13 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Female; Humans; Infant, N	2019
Prophylactic low-dose paracetamol administration associated with lowered rate of patent ductus arteriosus in preterm infants - Impact on outcome and pain perception. Pediatrics and neonatology, 2020, Volume: 61, Issue:1 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Infant, Premature	2020
Oral ibuprofen is superior to oral paracetamol for patent ductus arteriosus in very low and extremely low birth weight infants. Medicine, 2019, Volume: 98, Issue:31 Topics: Acetaminophen; Administration, Oral; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Du	2019
Intravenous paracetamol for patent ductus arteriosus in premature infants - a lower dose is also effective. Concerning the article by M.Y. Oncel et al: Intravenous paracetamol treatment in the management of patent ductus arteriosus in extremely low birth Neonatology, 2013, Volume: 104, Issue:1 Topics: Acetaminophen; Cardiovascular Agents; Ductus Arteriosus, Patent; Female; Humans; Infant, Low Birth W	2013
Is paracetamol safe and effective for ductus arteriosus closure? Archives of disease in childhood, 2013, Volume: 98, Issue:10 Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Humans; Infant, Newborn; Treatme	2013
[Re: medication error in an extremely low birth weight infant: paracetamol overdose]. Archivos argentinos de pediatria, 2013, Volume: 111, Issue:3 Topics: Acetaminophen; Drug Overdose; Ductus Arteriosus, Patent; Female; Humans; Infant, Extremely Low Birth	2013
[Author reply]. Archivos argentinos de pediatria, 2013, Volume: 111, Issue:3 Topics: Acetaminophen; Drug Overdose; Ductus Arteriosus, Patent; Female; Humans; Infant, Extremely Low Birth	2013
Is paracetamol a useful treatment for ibuprofen-resistant patent ductus arteriosus?. Concerning the article by M.Y. Oncel et al: intravenous paracetamol treatment in the management of patent ductus arteriosus in extremely low birth weight infants [Neonato Neonatology, 2013, Volume: 104, Issue:3 Topics: Acetaminophen; Cardiovascular Agents; Ductus Arteriosus, Patent; Female; Humans; Infant, Low Birth W	2013
Paracetamol for ductus arteriosus closure: not always a success story. Concerning the article by M.Y. Oncel et al: intravenous paracetamol treatment in the management of patent ductus arteriosus in extremely low birth weight infants [Neonatology 2013;103: Neonatology, 2013, Volume: 104, Issue:3 Topics: Acetaminophen; Cardiovascular Agents; Ductus Arteriosus, Patent; Female; Humans; Infant, Low Birth W	2013
Paracetamol therapy for patent ductus arteriosus in premature infants: a chance before surgical ligation. Pediatric cardiology, 2014, Volume: 35, Issue:2 Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Cardiac Surgical Procedures; Dose-Res	2014
Early paracetamol treatment associated with lowered risk of persistent ductus arteriosus in very preterm infants. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2014, Volume: 27, Issue:12 Topics: Acetaminophen; Birth Weight; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibuprofen;	2014
Early paracetamol treatment associated with lowered risk of persistent ductus arteriosus in very preterm infants. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2014, Volume: 27, Issue:12 Topics: Acetaminophen; Birth Weight; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibuprofen;	2014
Early paracetamol treatment associated with lowered risk of persistent ductus arteriosus in very preterm infants. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2014, Volume: 27, Issue:12 Topics: Acetaminophen; Birth Weight; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibuprofen;	2014
Early paracetamol treatment associated with lowered risk of persistent ductus arteriosus in very preterm infants. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2014, Volume: 27, Issue:12 Topics: Acetaminophen; Birth Weight; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibuprofen;	2014
Paracetamol effectiveness, safety and blood level monitoring during patent ductus arteriosus closure: a case series. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2014, Volume: 27, Issue:16 Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Humans; Infant, Newborn; Infant,	2014
Efficacy of paracetamol for the treatment of patent ductus arteriosus in preterm neonates. Italian journal of pediatrics, 2014, Feb-20, Volume: 40, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Birth Weight; Dose-Response Relationship, Drug; Ductus Arte	2014
Efficacy of paracetamol on patent ductus arteriosus closure may be dose dependent: evidence from human and murine studies. Pediatric research, 2014, Volume: 76, Issue:3 Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Animals; Blood Pressure; Cyclooxyg	2014
Acetaminophen: a possible alternative to ibuprofen in patent ductus arteriosus closure. The Journal of pediatrics, 2014, Volume: 165, Issue:1 Topics: Acetaminophen; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen	2014
Paracetamol-induced ductal closure in a 5-month-old infant. Cardiology in the young, 2015, Volume: 25, Issue:2 Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Humans; Infant; Infant, Prematur	2015
Intravenous paracetamol with a lower dose is also effective for the treatment of patent ductus arteriosus in pre-term infants. Cardiology in the young, 2015, Volume: 25, Issue:6 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Birth Weight; Drug Administrat	2015
Oral versus intravenous paracetamol: which is better in closure of patent ductus arteriosus in very low birth weight infants? The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2016, Volume: 29, Issue:1 Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Analgesics, Non-Narcotic; Ductus A	2016
[Paracetamol could be useful in the treatment of patent ductus arteriosus in the very-low-birth-weight infant]. Anales de pediatria (Barcelona, Spain : 2003), 2015, Volume: 82, Issue:5 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant, Newborn; Infant, Very Low Birth We	2015
Late medical therapy of patent ductus arteriosus using intravenous paracetamol. Archives of disease in childhood. Fetal and neonatal edition, 2015, Volume: 100, Issue:3 Topics: Acetaminophen; Administration, Intravenous; Ductus Arteriosus, Patent; Female; Humans; Infant, Newbo	2015
Late medical therapy of patent ductus arteriosus using intravenous paracetamol. Archives of disease in childhood. Fetal and neonatal edition, 2015, Volume: 100, Issue:3 Topics: Acetaminophen; Administration, Intravenous; Ductus Arteriosus, Patent; Female; Humans; Infant, Newbo	2015
Late medical therapy of patent ductus arteriosus using intravenous paracetamol. Archives of disease in childhood. Fetal and neonatal edition, 2015, Volume: 100, Issue:3 Topics: Acetaminophen; Administration, Intravenous; Ductus Arteriosus, Patent; Female; Humans; Infant, Newbo	2015
Late medical therapy of patent ductus arteriosus using intravenous paracetamol. Archives of disease in childhood. Fetal and neonatal edition, 2015, Volume: 100, Issue:3 Topics: Acetaminophen; Administration, Intravenous; Ductus Arteriosus, Patent; Female; Humans; Infant, Newbo	2015
Ductal closure with intravenous paracetamol: a new approach to patent ductus arteriosus treatment. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2016, Volume: 29, Issue:6 Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Female; Humans; Infant, Newborn;	2016
Ductus Arteriosus Closure With Paracetamol: a Pilot Study. Revista espanola de cardiologia (English ed.), 2015, Volume: 68, Issue:5 Topics: Acetaminophen; Analgesics, Non-Narcotic; Cardiac Surgical Procedures; Ductus Arteriosus, Patent; Fem	2015
Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure. European journal of pediatrics, 2015, Volume: 174, Issue:11 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-	2015
Paracetamol in Patent Ductus Arteriosus, "Flavour of the Month" or Here to Stay? Indian pediatrics, 2015, Volume: 52, Issue:7 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Male	2015
Paracetamol for Closure of Patent Ductus Arteriosus. Indian pediatrics, 2015, Volume: 52, Issue:7 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Male	2015
When to Close Patent Ductus arteriosus, The Ideal Time and Rationale. Indian pediatrics, 2016, Volume: 53, Issue:1 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Male	2016
When to Close Patent Ductus Arteriosus, Authors Reply. Indian pediatrics, 2016, Volume: 53, Issue:1 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Male	2016
[Paracetamol treatment for patent ductus arteriosus in premature infants: a review]. Zhonghua er ke za zhi = Chinese journal of pediatrics, 2015, Volume: 53, Issue:12 Topics: Acetaminophen; Ductus Arteriosus, Patent; Humans; Infant; Infant, Newborn; Infant, Premature	2015
Oral Paracetamol for Closure of Patent Ductus Arteriosus in Selected Preterm Neonates. Indian pediatrics, 2016, Volume: 53, Issue:2 Topics: Acetaminophen; Administration, Oral; Contraindications; Ductus Arteriosus, Patent; Humans; Ibuprofen	2016
Acetaminophen to avoid surgical ligation in extremely low gestational age neonates with persistent hemodynamically significant patent ductus arteriosus. Journal of perinatology : official journal of the California Perinatal Association, 2016, Volume: 36, Issue:8 Topics: Acetaminophen; Canada; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Echocardiography; Femal	2016
Intravenous paracetamol for PDA closure in the preterm: a single-center experience. European journal of pediatrics, 2016, Volume: 175, Issue:7 Topics: Acetaminophen; Administration, Intravenous; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Ec	2016
Acetaminophen to Prevent Symptomatic Patent Ductus Arteriosus: Another Drug Bites the Dust? The Journal of pediatrics, 2016, Volume: 177 Topics: Acetaminophen; Ductus Arteriosus, Patent; Dust; Humans; Infant, Newborn; Infant, Premature; Persiste	2016
Effectiveness and safety of treatments used for the management of patent ductus arteriosus (PDA) in preterm infants: a protocol for a systematic review and network meta-analysis. BMJ open, 2016, 07-25, Volume: 6, Issue:7 Topics: Acetaminophen; Administration, Oral; Bayes Theorem; Cyclooxygenase Inhibitors; Ductus Arteriosus, Pa	2016
The Role of Paracetamol for Closing Patent Ductus Arteriosus. A Challenging Alternative for Ductal Closure? Revista espanola de cardiologia (English ed.), 2016, Volume: 69, Issue:11 Topics: Acetaminophen; Administration, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Hemorr	2016
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics, 2011, Volume: 128, Issue:6 Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Infant; Infant, Newborn; Male	2011
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants. Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate	2013
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants. Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate	2013
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants. Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate	2013
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants. Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate	2013
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants. Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate	2013
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants. Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate	2013
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants. Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate	2013
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants. Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate	2013
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants. Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate	2013
Intravenous paracetamol treatment in the management of patent ductus arteriosus in extremely low birth weight infants. Neonatology, 2013, Volume: 103, Issue:3 Topics: Acetaminophen; Cardiovascular Agents; Chi-Square Distribution; Drug Administration Schedule; Ductus	2013
Intravenous paracetamol treatment in the management of patent ductus arteriosus in extremely low birth weight infants. Neonatology, 2013, Volume: 103, Issue:3 Topics: Acetaminophen; Cardiovascular Agents; Chi-Square Distribution; Drug Administration Schedule; Ductus	2013
Intravenous paracetamol treatment in the management of patent ductus arteriosus in extremely low birth weight infants. Neonatology, 2013, Volume: 103, Issue:3 Topics: Acetaminophen; Cardiovascular Agents; Chi-Square Distribution; Drug Administration Schedule; Ductus	2013
Intravenous paracetamol treatment in the management of patent ductus arteriosus in extremely low birth weight infants. Neonatology, 2013, Volume: 103, Issue:3 Topics: Acetaminophen; Cardiovascular Agents; Chi-Square Distribution; Drug Administration Schedule; Ductus	2013
In utero ductal closure following near-term maternal self-medication with nimesulide and acetaminophen. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2002, Volume: 22, Issue:4 Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Biological Products; Cesarean Section	2002

acetaminophen and Ductus Arteriosus, Patent