acetaminophen has been researched along with Drug Overdose in 1211 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen (APAP) is the most common drug overdose in pregnancy." | 8.82 | Acetaminophen overdose in pregnancy. ( Clark, LE; Herrera, JL; Wilkes, JM, 2005) |
| "An unusual case of severe thrombocytopenia following acetaminophen overdose is presented along with a retrospective review of 174 patients with hospital admissions for acute acetaminophen toxicity." | 8.79 | Thrombocytopenia following acute acetaminophen overdose. ( Fischereder, M; Jaffe, JP, 1994) |
| "This case illustrates that hypoglycemia can be a presenting symptom in patients with an acute overdose of tramadol with no previous history of glycemic dysregulation." | 8.12 | A Case Report of Hypoglycemia Following a Tramadol Overdose in a Non-Diabetic Patient. ( Bush, JS; Clendening, AM; Weant, KA, 2022) |
| "This study therefore aimed at investigating effects of acetaminophen on pathogenesis in hamsters for opisthorchiasis." | 8.02 | Acetaminophen Overdose Enhances Early Cholangiocarcinoma in Opisthorchiasis Hamsters. ( Artchayasawat, A; Aukkanimart, R; Boonmars, T; Borlace, GN; Pumhirunroj, B; Ratanasuwan, P; Sriraj, P, 2021) |
| " The primary outcomes were: (1) hyperlactatemia, defined as a lactate concentration ≥ 2 mmol/L at any point during hospital admission and, (2) metformin associated lactic acidosis (MALA), defined as a lactate concentration ≥ 5 mmol/L and pH <7." | 7.91 | Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. ( Hoffman, RS; Manini, AF; Taub, ES, 2019) |
| "Rhabdomyolysis and delayed acetaminophen hepatotoxicity may be associated with elevated serum transaminase values." | 7.88 | Transaminase and Creatine Kinase Ratios for Differentiating Delayed Acetaminophen Overdose from Rhabdomyolysis. ( Albertson, TE; Algren, DA; Chenoweth, JA; Ford, JB; Owen, KP; Radke, JB; Sutter, ME, 2018) |
| "Acute kidney injury (AKI) occurs in 2-10% of patients with acetaminophen (APAP) overdose." | 7.83 | Incidence and characterization of acute kidney injury after acetaminophen overdose. ( Rice, TW; Stollings, JL; Wheeler, AP, 2016) |
| "In cases of severe acetaminophen-induced acute liver failure and hepatic encephalopathy, liver transplant can be the only real hope for neurologic recovery and indeed survival." | 7.80 | Liver transplant for intentional acetaminophen overdose and hepatic encephalopathy: a conflict between beneficence and justice. ( Tolchin, BD; Willey, JZ, 2014) |
| " The authors of this study reported a case of hepatotoxicity in a patient treated with capecitabine for breast cancer." | 7.80 | [Hepatotoxicity of acetaminophen in a patient treated with capecitabine due to breast cancer]. ( Drzymała, M; Golon, K; Karczmarek-Borowska, B, 2014) |
| "Acetaminophen overdose can lead to severe liver and kidney failure; however, the risk of therapeutic doses in healthy individuals causing acute kidney injury (AKI) is less clear." | 7.80 | Therapeutic dose of acetaminophen as a possible risk factor for acute kidney injury: learning from two healthy young adult cases. ( Asakawa, S; Fujigaki, Y; Furunishi, J; Higaki, M; Hoshimoto, K; Inoue, R; Kato, H; Shima, T; Shin, S; Tanemoto, M; Uchida, S; Uozaki, H; Yamaguchi, Y, 2014) |
| "Acetaminophen overdose is the most rapidly growing cause of fulminant hepatic failure in Western countries." | 7.79 | Accidental acetaminophen overdose results in liver transplant during second trimester of pregnancy: a case report. ( Franko, KR; Hemming, AW; Khanna, A; Mekeel, KL; Woelkers, D, 2013) |
| "There are few reports of acetaminophen overdose in hypothermic patients and even fewer reports describing profound hypothermia." | 7.79 | Acetaminophen/diphenhydramine overdose in profound hypothermia. ( Rollstin, AD; Seifert, SA, 2013) |
| "The objective of this study was to determine the reliability of denial of acetaminophen ingestion in intentional drug overdose patients." | 7.77 | Reliability of history of acetaminophen ingestion in intentional drug overdose patients. ( Basis, F; Bentur, Y; Keyes, DC; Lurie, Y; Tamir, A, 2011) |
| "The systemic inflammatory response syndrome (SIRS) and sequential organ failure assessment (SOFA) scores are widely used as prognostic markers in critical care settings and could improve triage of high-risk paracetamol (acetaminophen) overdose patients." | 7.77 | The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose. ( Craig, DG; Davidson, JS; Hayes, PC; Martin, KG; Reid, TW; Simpson, KJ, 2011) |
| "We highlight the risk associated with acetaminophen misuse in patients having dental pain in France based on a series of cases of unintentional acetaminophen overdose reported by the Emergency Dental Service of Nancy over a 9-month period." | 7.77 | Misuse of acetaminophen in the management of dental pain. ( Clement, C; Gambier, N; Gillet, P; Javot, L; Petitpain, N; Royer-Morrot, MJ; Scala-Bertola, J; Trechot, P, 2011) |
| "This study intended to determine the prevalence of hypokalemia and its clinical correlates in acute psychiatric illness among hypokalemic and normokalemic patients after acetaminophen overdose." | 7.76 | High prevalence of hypokalemia after acute acetaminophen overdose: impact of psychiatric illness. ( Al-jabi, SW; Awang, R; Syed Sulaiman, SA; Zyoud, SH, 2010) |
| "Acetylcysteine is an antidote used to prevent liver failure after acetaminophen overdose." | 7.75 | Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine. ( Hayes, BD; Sarmiento, KF; Schwartz, EA, 2009) |
| "We report the case of a 35-year-old woman who presented with acute pancreatitis and severe metabolic acidosis after overdosing on a drug containing acetaminophen." | 7.75 | Acetaminophen-induced acute pancreatitis. A case report. ( Igarashi, H; Ito, T; Oono, T; Sakai, H; Takayanagi, R; Yoshinaga, M, 2009) |
| "No relationship was found between the extent of acute acetaminophen exposure and proteinuria." | 7.74 | Proteinuria is unrelated to the extent of acute acetaminophen overdose: a prospective clinical study. ( Benhalim, S; Jamie, H; Leggett, GE; Waring, WS, 2008) |
| "A 28-year-old man with schizophrenia intentionally ingested a lethal dose of acetaminophen and an unknown quantity of ibuprofen." | 7.74 | Rhabdomyolysis and necrotic bowel after acetaminophen and ibuprofen overdose. ( Dunn, T; Katz, D; Nelson, H; Singh, G; Thomsen, D; Voigt, M; Whitaker, E, 2007) |
| "Paracetamol (acetaminophen) poisoning is the leading cause of acute liver failure in Great Britain and the United States." | 7.74 | Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning. ( Griffiths, C; Majeed, A; Morgan, OW, 2007) |
| "An 18-year-old male developed a severe serotonin syndrome after recreational ingestion of Coricidin HBP (chlorpheniramine 4 mg and dextromethorphan hydrobromide 30 mg)." | 7.74 | Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy. ( Babu, KM; Boyer, EW; Ganetsky, M, 2007) |
| "During the 10-year interval, 1543 patients were hospitalized for acetaminophen overdose; 34% were alcohol abusers, 3% had liver disease, and 13% overdosed unintentionally." | 7.74 | Impact of liver disease, alcohol abuse, and unintentional ingestions on the outcomes of acetaminophen overdose. ( Dean, S; Li, B; Myers, RP; Quan, H; Shaheen, AA, 2008) |
| "Renal insufficiency is less common than liver failure in acetaminophen overdose but renal tubular damage occurs even in the absence of hepatotoxicity." | 7.73 | Experiences of a poison center network with renal insufficiency in acetaminophen overdose: an analysis of 17 cases. ( Hengstler, JG; Hermanns-Clausen, M; Kaes, J; Koch, I; Lauterbach, M; von Mach, MA; Weilemann, LS, 2005) |
| "To identify risk factors in the development of side-effects to N-acetylcysteine (NAC) in patients with paracetamol poisoning." | 7.71 | Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning. ( Dalhoff, K; Schmidt, LE, 2001) |
| " Although her consciousness and hemodynamic status gradually improved after treatment with N-acetylcysteine and other supportive measures, she was found to have pancytopenia, pancreatitis and hepatorenal failure during the hospitalization and eventually died 18 d post-admission." | 7.71 | Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning. ( Deng, JF; Lin, TJ; Yang, CC, 2001) |
| "To report a case of metabolic acidosis and coma in a severe acetaminophen overdose." | 7.70 | Metabolic acidosis and coma following a severe acetaminophen overdose. ( Jones, G; Koulouris, Z; Tierney, MG, 1999) |
| "Screening for acetaminophen toxicity is recommended in almost all cases of self poisoning." | 7.70 | Predictive properties of a qualitative urine acetaminophen screen in patients with self-poisoning. ( De Roos, F; Hollander, JE; Perrone, J; Shaw, L, 1999) |
| "In long-term alcohol users, the syndrome of hepatotoxicity from acetaminophen taken in therapeutic or modestly excessive doses is distinctive." | 7.70 | Alcohol-acetaminophen syndrome. Even moderate social drinkers are at risk. ( Cox, C; Draganov, P; Durrence, H; Reuben, A, 2000) |
| "We report three patients who experienced hepatotoxic reactions in association with acetaminophen ingestion while undergoing treatment for active tuberculosis with isoniazid, rifampin, and other agents." | 7.69 | Hepatotoxicity associated with acetaminophen usage in patients receiving multiple drug therapy for tuberculosis. ( Nelson, SD; Nolan, CM; Sandblom, RE; Slattery, JT; Thummel, KE, 1994) |
| "To describe the efficacy of ondansetron for the treatment of poisoning-associated vomiting in two patients following drug intoxication." | 7.69 | Ondansetron for treating nausea and vomiting in the poisoned patient. ( Marx, CM; Reed, MD, 1994) |
| "Prazosin's increase in popularity as a treatment for posttraumatic stress disorder makes it important for emergency physicians to be aware of how to manage potential toxic ingestion because of prazosin overdose." | 6.58 | Refractory Hypotension Caused by Prazosin Overdose Combined With Acetaminophen and Naproxen Toxicity: A Case Report and Review of the Literature. ( Anderson, C; Gupta, R; Lim, RK; Lynch, T, 2018) |
| "Patients with cystic fibrosis are more likely to have glutathione deficiency, and greater susceptibility to liver injury." | 5.48 | Hepatotoxicity after paracetamol overdose in a patient with cystic fibrosis despite early acetylcysteine and utility of microRNA to predict hepatotoxicity. ( Cheung, B; Gantier, M; Graudins, A; Nejad, C; Wong, A, 2018) |
| "Toxic myocarditis is an extremely rare complication of acetaminophen overdose." | 5.46 | Toxic Myocarditis Caused by Acetaminophen in a Multidrug Overdose. ( Crahes, M; Dazé, Y; Gosselin, M; Mireault, P, 2017) |
| " In cases of massive acetaminophen overdose, standard acetylcysteine dosing may not be adequate." | 5.37 | Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose. ( Bagdure, D; Heard, K; Monte, A; Wang, GS, 2011) |
| " While dosing errors are common, in most cases, overdoses produce minimal clinical effects." | 5.37 | Massive acetylcysteine overdose associated with cerebral edema and seizures. ( Heard, K; Schaeffer, TH, 2011) |
| "Hypothyroidism was induced by methimazole, propylthiouracil, or surgical thyroidectomy and confirmed by elevated serum levels of TSH." | 5.30 | Hypothyroidism protects rat liver from acetaminophen hepatotoxicity. ( Aeed, H; Avni, Y; Bruck, R; Frenkel, D; Halpern, Z; Matas, Z; Oren, R; Papa, M; Shirin, H; Zaidel, L, 1999) |
| "Acetaminophen serum levels were rather low compared to cases with ingestion of one single overdose." | 5.30 | Fulminant liver failure in a young child following repeated acetaminophen overdosing. ( Babel, B; Bauer, M; Giesen, H; Patzelt, D, 1999) |
| "Acetaminophen is generally regarded as a safe antipyretic and analgetic agent and is widely used in cases of pregnancy." | 5.22 | Hepatic failure with fatal outcome during pregnancy following administration of a single therapeutic dose of acetominophen: Case report and literature review. ( Gao, Y; Huang, Y; Liang, H; Zhang, R, 2022) |
| " The aim of this review is to determine if there are any clinically relevant differences in safety between ibuprofen and paracetamol that may recommend one agent over the other in the management of fever and discomfort in children older than 3 months of age." | 4.95 | A clinical and safety review of paracetamol and ibuprofen in children. ( Kanabar, DJ, 2017) |
| "Paracetamol (acetaminophen) is one of the most popular and widely used drugs for the treatment of pain and fever in children." | 4.90 | Paracetamol: a focus for the general pediatrician. ( Barbi, E; Guarino, S; Marzuillo, P, 2014) |
| "The use of intravenous acetylcysteine for off-label indications, specifically non-acetaminophen-induced acute liver failure (NAI-ALF), severe alcoholic hepatitis, and contrast-induced nephropathy (CIN), is reviewed." | 4.89 | Intravenous acetylcysteine for indications other than acetaminophen overdose. ( Bass, S; Zook, N, 2013) |
| "Paracetamol (acetaminophen) is the most common drug taken in overdose in the UK, accounting for 48% of poisoning admissions to hospital and being involved in an estimated 100-200 deaths per year." | 4.84 | Impact of restricting paracetamol pack sizes on paracetamol poisoning in the United Kingdom: a review of the literature. ( Dargan, PI; Edwards, JN; Hawkins, LC, 2007) |
| "Acetaminophen (APAP) is the most common drug overdose in pregnancy." | 4.82 | Acetaminophen overdose in pregnancy. ( Clark, LE; Herrera, JL; Wilkes, JM, 2005) |
| "Acetaminophen is the most commonly reported drug overdose in the United States." | 4.79 | Acute renal failure due to acetaminophen ingestion: a case report and review of the literature. ( Blakely, P; McDonald, BR, 1995) |
| "An unusual case of severe thrombocytopenia following acetaminophen overdose is presented along with a retrospective review of 174 patients with hospital admissions for acute acetaminophen toxicity." | 4.79 | Thrombocytopenia following acute acetaminophen overdose. ( Fischereder, M; Jaffe, JP, 1994) |
| "This case illustrates that hypoglycemia can be a presenting symptom in patients with an acute overdose of tramadol with no previous history of glycemic dysregulation." | 4.12 | A Case Report of Hypoglycemia Following a Tramadol Overdose in a Non-Diabetic Patient. ( Bush, JS; Clendening, AM; Weant, KA, 2022) |
| "This study therefore aimed at investigating effects of acetaminophen on pathogenesis in hamsters for opisthorchiasis." | 4.02 | Acetaminophen Overdose Enhances Early Cholangiocarcinoma in Opisthorchiasis Hamsters. ( Artchayasawat, A; Aukkanimart, R; Boonmars, T; Borlace, GN; Pumhirunroj, B; Ratanasuwan, P; Sriraj, P, 2021) |
| "The aim of this study was to evaluate the therapeutic ability of CA methanol extract (CAM) in protecting mouse brain and astrocytes from oxidative stress and inflammation induced by Paracetamol, and thus to substantiate the allied traditional/ethnomedical claims of CA." | 3.91 | Protection of mouse brain from paracetamol-induced stress by Centella asiatica methanol extract. ( Baby, S; Dan, VM; Nair, AS; Radhakrishnan, N; Rajendran Nair, AP; Viswanathan, G, 2019) |
| " The primary outcomes were: (1) hyperlactatemia, defined as a lactate concentration ≥ 2 mmol/L at any point during hospital admission and, (2) metformin associated lactic acidosis (MALA), defined as a lactate concentration ≥ 5 mmol/L and pH <7." | 3.91 | Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. ( Hoffman, RS; Manini, AF; Taub, ES, 2019) |
| "Rhabdomyolysis and delayed acetaminophen hepatotoxicity may be associated with elevated serum transaminase values." | 3.88 | Transaminase and Creatine Kinase Ratios for Differentiating Delayed Acetaminophen Overdose from Rhabdomyolysis. ( Albertson, TE; Algren, DA; Chenoweth, JA; Ford, JB; Owen, KP; Radke, JB; Sutter, ME, 2018) |
| "Acetaminophen (APAP) overdose induces severe oxidative stress followed by hepatocyte apoptosis/necrosis." | 3.85 | Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress. ( Aoyama, T; Arai, K; Ikejima, K; Kon, K; Kusama, H; Uchiyama, A; Watanabe, S; Yamashina, S, 2017) |
| "We compared the incidence of adverse drug events of a two-bag IV acetylcysteine regimen with that of the traditional three-bag regimen." | 3.83 | Simplification of the standard three-bag intravenous acetylcysteine regimen for paracetamol poisoning results in a lower incidence of adverse drug reactions. ( Graudins, A; Wong, A, 2016) |
| "Acetaminophen was the most frequently chosen substance compared to other drugs in acute drug overdose (P=0." | 3.83 | [A prospective study on suicide attempts by self-poisoning in adolescents: Symptoms and complications]. ( Brouard, J; Le Vaillant, J; Nimal-Cuvillon, D; Pellerin, L, 2016) |
| " Hemodialysis appears to be a beneficial therapeutic option in cases of massive acetaminophen ingestion with coma and lactic acidosis." | 3.83 | Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics. ( Ghannoum, M; Gosselin, S; Grunbaum, AM; Kazim, S; Villeneuve, E, 2016) |
| "Acute kidney injury (AKI) occurs in 2-10% of patients with acetaminophen (APAP) overdose." | 3.83 | Incidence and characterization of acute kidney injury after acetaminophen overdose. ( Rice, TW; Stollings, JL; Wheeler, AP, 2016) |
| "In cases of severe acetaminophen-induced acute liver failure and hepatic encephalopathy, liver transplant can be the only real hope for neurologic recovery and indeed survival." | 3.80 | Liver transplant for intentional acetaminophen overdose and hepatic encephalopathy: a conflict between beneficence and justice. ( Tolchin, BD; Willey, JZ, 2014) |
| " The authors of this study reported a case of hepatotoxicity in a patient treated with capecitabine for breast cancer." | 3.80 | [Hepatotoxicity of acetaminophen in a patient treated with capecitabine due to breast cancer]. ( Drzymała, M; Golon, K; Karczmarek-Borowska, B, 2014) |
| "Acetaminophen overdose can lead to severe liver and kidney failure; however, the risk of therapeutic doses in healthy individuals causing acute kidney injury (AKI) is less clear." | 3.80 | Therapeutic dose of acetaminophen as a possible risk factor for acute kidney injury: learning from two healthy young adult cases. ( Asakawa, S; Fujigaki, Y; Furunishi, J; Higaki, M; Hoshimoto, K; Inoue, R; Kato, H; Shima, T; Shin, S; Tanemoto, M; Uchida, S; Uozaki, H; Yamaguchi, Y, 2014) |
| "Acetaminophen overdose is the most rapidly growing cause of fulminant hepatic failure in Western countries." | 3.79 | Accidental acetaminophen overdose results in liver transplant during second trimester of pregnancy: a case report. ( Franko, KR; Hemming, AW; Khanna, A; Mekeel, KL; Woelkers, D, 2013) |
| "Haemodialysis is sometimes used for patients with massive acetaminophen overdose when signs of "mitochondrial paralysis" (lactic acidosis, altered mental status, hypothermia and hyperglycaemia) are present." | 3.79 | Antidote removal during haemodialysis for massive acetaminophen overdose. ( Garland, JS; Hanly, LN; Juurlink, DN; Lenga, I; Poley, R; Sivilotti, ML; Thompson, M, 2013) |
| "There are few reports of acetaminophen overdose in hypothermic patients and even fewer reports describing profound hypothermia." | 3.79 | Acetaminophen/diphenhydramine overdose in profound hypothermia. ( Rollstin, AD; Seifert, SA, 2013) |
| "We describe the case of a 34-year-old woman who developed flexion myelopathy resulting in severe quadriparesis after overdose of quetiapine fumarate, oxycodone/acetaminophen, and chloral hydrate." | 3.78 | Window of opportunity: flexion myelopathy after drug overdose. ( Damek, DM; Nielsen, AS, 2012) |
| "A comatose 23-year-old woman with acute liver failure due to an overdose of acetaminophen had indications of intracranial hypertension and underwent liver transplantation." | 3.78 | Therapeutic hypothermia for treatment of intractable intracranial hypertension after liver transplantation. ( Fox, AD; Holena, DN; Levine, JM; Mills, AM; Tolstoy, NS, 2012) |
| "We describe a 36 year old patient with ALF and brain edema from acetaminophen overdose who had an EVD placed for ICP monitoring and management." | 3.77 | Emergent, controlled lumbar drainage for intracranial pressure monitoring during orthotopic liver transplantation. ( Arasi, L; Bacani, CJ; Canabal, JC; Di Trapani, RA; Freeman, WD; Shine, T; Willingham, DL, 2011) |
| "The systemic inflammatory response syndrome (SIRS) and sequential organ failure assessment (SOFA) scores are widely used as prognostic markers in critical care settings and could improve triage of high-risk paracetamol (acetaminophen) overdose patients." | 3.77 | The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose. ( Craig, DG; Davidson, JS; Hayes, PC; Martin, KG; Reid, TW; Simpson, KJ, 2011) |
| "We highlight the risk associated with acetaminophen misuse in patients having dental pain in France based on a series of cases of unintentional acetaminophen overdose reported by the Emergency Dental Service of Nancy over a 9-month period." | 3.77 | Misuse of acetaminophen in the management of dental pain. ( Clement, C; Gambier, N; Gillet, P; Javot, L; Petitpain, N; Royer-Morrot, MJ; Scala-Bertola, J; Trechot, P, 2011) |
| "This study intended to determine the prevalence of hypokalemia and its clinical correlates in acute psychiatric illness among hypokalemic and normokalemic patients after acetaminophen overdose." | 3.76 | High prevalence of hypokalemia after acute acetaminophen overdose: impact of psychiatric illness. ( Al-jabi, SW; Awang, R; Syed Sulaiman, SA; Zyoud, SH, 2010) |
| "Acetylcysteine is an antidote used to prevent liver failure after acetaminophen overdose." | 3.75 | Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine. ( Hayes, BD; Sarmiento, KF; Schwartz, EA, 2009) |
| "We report the case of a 35-year-old woman who presented with acute pancreatitis and severe metabolic acidosis after overdosing on a drug containing acetaminophen." | 3.75 | Acetaminophen-induced acute pancreatitis. A case report. ( Igarashi, H; Ito, T; Oono, T; Sakai, H; Takayanagi, R; Yoshinaga, M, 2009) |
| "No relationship was found between the extent of acute acetaminophen exposure and proteinuria." | 3.74 | Proteinuria is unrelated to the extent of acute acetaminophen overdose: a prospective clinical study. ( Benhalim, S; Jamie, H; Leggett, GE; Waring, WS, 2008) |
| "A 28-year-old man with schizophrenia intentionally ingested a lethal dose of acetaminophen and an unknown quantity of ibuprofen." | 3.74 | Rhabdomyolysis and necrotic bowel after acetaminophen and ibuprofen overdose. ( Dunn, T; Katz, D; Nelson, H; Singh, G; Thomsen, D; Voigt, M; Whitaker, E, 2007) |
| "Paracetamol (acetaminophen) poisoning is the leading cause of acute liver failure in Great Britain and the United States." | 3.74 | Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning. ( Griffiths, C; Majeed, A; Morgan, OW, 2007) |
| "The inclusion criteria were age between 3 and 36 months, main complaint of fever and at least one dose of dipyrone or acetaminophen given to the child during the 24 hours preceding their arrival at the emergency department." | 3.74 | Dipyrone and acetaminophen: correct dosing by parents? ( Almeida, CD; Almeida, ND; Alves, JG; Cardoso Neto, FJ, 2007) |
| " The present study was conducted to investigate the expression of hepatobiliary efflux transporters in livers from patients after toxic acetaminophen (APAP) ingestion, with livers from patients with primary biliary cirrhosis (PBC) serving as positive controls." | 3.74 | Induction of hepatobiliary efflux transporters in acetaminophen-induced acute liver failure cases. ( Aleksunes, LM; Augustine, L; Barnes, SN; Cherrington, NJ; Goedken, MJ; Jakowski, AB; Manautou, JE; Pruimboom-Brees, IM; Scheffer, GL, 2007) |
| "An 18-year-old male developed a severe serotonin syndrome after recreational ingestion of Coricidin HBP (chlorpheniramine 4 mg and dextromethorphan hydrobromide 30 mg)." | 3.74 | Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy. ( Babu, KM; Boyer, EW; Ganetsky, M, 2007) |
| " However, recent case reports have suggested that acetaminophen concentrations may be falsely increased in the presence of hyperbilirubinemia." | 3.74 | False positive acetaminophen concentrations in patients with liver injury. ( Balko, JA; Fuller, D; Hynan, LS; Khan, AI; Koff, JM; Lee, WM; Murray, NG; Orsulak, P; Polson, J; Wians, FH, 2008) |
| "During the 10-year interval, 1543 patients were hospitalized for acetaminophen overdose; 34% were alcohol abusers, 3% had liver disease, and 13% overdosed unintentionally." | 3.74 | Impact of liver disease, alcohol abuse, and unintentional ingestions on the outcomes of acetaminophen overdose. ( Dean, S; Li, B; Myers, RP; Quan, H; Shaheen, AA, 2008) |
| "Renal insufficiency is less common than liver failure in acetaminophen overdose but renal tubular damage occurs even in the absence of hepatotoxicity." | 3.73 | Experiences of a poison center network with renal insufficiency in acetaminophen overdose: an analysis of 17 cases. ( Hengstler, JG; Hermanns-Clausen, M; Kaes, J; Koch, I; Lauterbach, M; von Mach, MA; Weilemann, LS, 2005) |
| "The results of this survey concerning antipyretic treatment of children by their Jewish and Bedouin Moslem caregivers suggest that lighter body weight and the use of acetaminophen rectal suppositories were associated with the administration of higher-than-recommended doses of acetaminophen." | 3.73 | Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study. ( Bilenko, N; Gorodischer, R; Okbe, R; Press, J; Tessler, H, 2006) |
| " As the two patients had developed hepatic encephalopathy they were treated with mannitol to reduce intra-cerebral oedema." | 3.72 | Renal transplants from non-heart beating paracetamol overdose donors. ( Bhatti, A; Gok, MA; Gupta, A; Olschewski, P; Robertson, H; Shenton, BK; Soomro, N; Talbot, D, 2004) |
| "Acetaminophen overdose and idiosyncratic drug reactions have replaced viral hepatitis as the most frequent apparent causes of acute liver failure." | 3.71 | Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. ( Blei, AT; Crippin, JS; Davern, TJ; Fontana, RJ; Han, SH; Hay, JE; Hynan, L; Larson, A; Lee, WM; McCashland, TM; Ostapowicz, G; Reisch, J; Samuel, G; Schiødt, FV; Shakil, AO, 2002) |
| "To identify risk factors in the development of side-effects to N-acetylcysteine (NAC) in patients with paracetamol poisoning." | 3.71 | Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning. ( Dalhoff, K; Schmidt, LE, 2001) |
| " Although her consciousness and hemodynamic status gradually improved after treatment with N-acetylcysteine and other supportive measures, she was found to have pancytopenia, pancreatitis and hepatorenal failure during the hospitalization and eventually died 18 d post-admission." | 3.71 | Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning. ( Deng, JF; Lin, TJ; Yang, CC, 2001) |
| "We describe a patient with acute liver and renal failure secondary to acetaminophen and chronic alcohol abuse who was treated aggressively with oral acetylcysteine, continuous renal replacement therapy, glucose and branched-chain amino acid intravenous feeding and ventilatory support." | 3.71 | Is continuous veno-venous hemofiltration for acetaminophen-induced acute liver and renal failure worthwhile? ( Agarwal, R; Farber, MO, 2002) |
| "A short cut review was carried out to establish whether vomiting was a significant consequence of paracetamol (acetaminophen) overdose." | 3.71 | Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Vomiting in paracetamol overdose. ( Clarke, S; Herren, K, 2002) |
| "Acetaminophen is frequently used in self-poisoning in Western countries." | 3.71 | Treatment strategies for early presenting acetaminophen overdose: a survey of medical directors of poison centers in North America and Europe. ( Kozer, E; McGuigan, M, 2002) |
| "To report a case of metabolic acidosis and coma in a severe acetaminophen overdose." | 3.70 | Metabolic acidosis and coma following a severe acetaminophen overdose. ( Jones, G; Koulouris, Z; Tierney, MG, 1999) |
| "Screening for acetaminophen toxicity is recommended in almost all cases of self poisoning." | 3.70 | Predictive properties of a qualitative urine acetaminophen screen in patients with self-poisoning. ( De Roos, F; Hollander, JE; Perrone, J; Shaw, L, 1999) |
| "In long-term alcohol users, the syndrome of hepatotoxicity from acetaminophen taken in therapeutic or modestly excessive doses is distinctive." | 3.70 | Alcohol-acetaminophen syndrome. Even moderate social drinkers are at risk. ( Cox, C; Draganov, P; Durrence, H; Reuben, A, 2000) |
| "We report three patients who experienced hepatotoxic reactions in association with acetaminophen ingestion while undergoing treatment for active tuberculosis with isoniazid, rifampin, and other agents." | 3.69 | Hepatotoxicity associated with acetaminophen usage in patients receiving multiple drug therapy for tuberculosis. ( Nelson, SD; Nolan, CM; Sandblom, RE; Slattery, JT; Thummel, KE, 1994) |
| "A case of fatal paracetamol (acetaminophen) poisoning in a 26-year-old woman who developed liver necrosis is described." | 3.69 | [A case of paracetamol retard poisoning with fatal outcome]. ( Lystbaek, BB; Nørregaard, P, 1995) |
| "We have analysed Kupffer cell and 'activated' perisinusoidal cell populations in liver biopsies from patients with paracetamol (acetaminophen)-induced hepatic necrosis of varying degrees of severity." | 3.69 | Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury. ( Burt, AD; Hines, JE; James, OF; Mathew, J, 1994) |
| "To describe the efficacy of ondansetron for the treatment of poisoning-associated vomiting in two patients following drug intoxication." | 3.69 | Ondansetron for treating nausea and vomiting in the poisoned patient. ( Marx, CM; Reed, MD, 1994) |
| "To determine whether the antidote for acetaminophen poisoning, N-acetylcysteine, administered to pregnant women with acetaminophen toxicity, crosses the placenta and can be measured in the newborn circulation following delivery." | 3.69 | Placental transfer of N-acetylcysteine following human maternal acetaminophen toxicity. ( Bearer, CF; Dart, RC; Gupta, U; Horowitz, RS; Jarvie, DR, 1997) |
| "Acetaminophen-protein adducts are specific biomarkers of toxic acetaminophen (paracetamol) metabolite exposure." | 2.94 | Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5). ( Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; James, LP; McArdle, K; Pickering, JW, 2020) |
| " This regimen was introduced in the 1970s and has remained largely unchanged even though the initial NAC infusion is frequently associated with adverse reactions, in particular nausea, vomiting, and anaphylactoid reactions." | 2.90 | Randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with the 12-h regimen of N-acetylcysteine for paracetamol overdose-the PP100-01 for Overdose of Paracetamol (POP) trial: study protocol for a randomi ( Dear, J, 2019) |
| " Primary endpoints: all participants experienced ≥1 adverse event (AE), most commonly gastrointestinal." | 2.90 | Principal results of a randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with a 12 h regimen of N-acetylcysteine for paracetamol overdose (POP trial). ( Black, P; Dear, JW; Gallagher, B; Grahamslaw, J; Henriksen, D; Lee, RJ; Morrison, EE; O'Brien, R; Oatey, K; Oosthuyzen, W; Weir, CJ, 2019) |
| " In a clinical study, healthy human subjects were dosed daily with 4 g of either acetaminophen or placebo pills for 7 days and evaluated over the course of 14 days." | 2.84 | Blood gene expression profiling of an early acetaminophen response. ( Bushel, PR; Fannin, RD; Gerrish, K; Paules, RS; Watkins, PB, 2017) |
| " The standard oral or intravenous dosing regimen of NAC is highly effective for patients with moderate overdoses who present within 8 h of APAP ingestion." | 2.82 | Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. ( Akakpo, JY; Curry, SC; Jaeschke, H; Ramachandran, A; Rumack, BH, 2022) |
| " However, the concentrations of APAP-CYS during therapeutic dosing, in cases of acetaminophen toxicity from repeated dosing and in cases of hepatic injury from non-acetaminophen hepatotoxins have not been well characterized." | 2.76 | Acetaminophen-cysteine adducts during therapeutic dosing and following overdose. ( Dart, RC; Green, JL; Heard, KJ; James, LP; Judge, BS; Rhyee, S; Zolot, L, 2011) |
| "Mechanisms responsible for anaphylactoid reactions to N-acetylcysteine (NAC) are poorly understood, and acetaminophen itself may play an important role." | 2.73 | Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose. ( Dow, MA; Pettie, JM; Robinson, OD; Stephen, AF; Waring, WS, 2008) |
| "Acetaminophen is a common ingestant that is routinely screened for, with serum testing, after overdoses." | 2.73 | Comparison of urine and serum testing for early detection of acetaminophen ingestion. ( Bebarta, VS; MacDaniel, J; Martin, JF; Schwertner, HA, 2007) |
| " N-Acetylcysteine should be given according to specific regimens through weight-based dosing tables." | 2.72 | Paracetamol overdose in the newborn and infant: a life-threatening event. ( Antonucci, R; Capobianco, G; Cuzzolin, L; Locci, C, 2021) |
| "Acetaminophen (APAP) is a widely used antipyretic and analgesic drug that is safe and effective in the therapeutic doses, but overdose may cause hepatotoxicity and even acute liver failure (ALF)." | 2.72 | [Research progress on hepatotoxicity of acetaminophen]. ( Hu, T; Huang, WQ; Sun, H, 2021) |
| "Acetaminophen is a common medication taken in deliberate self-poisoning and unintentional overdose." | 2.72 | Acetaminophen Poisoning. ( Buckley, NA; Chiew, AL, 2021) |
| " Several novel approaches to the management of acetaminophen overdose have been suggested to improve patient safety by reducing adverse drug reactions and dosing errors." | 2.72 | A review of alternative intravenous acetylcysteine regimens for acetaminophen overdose. ( Burnham, K; Knight, S; Smith, H; Yang, T, 2021) |
| " Maximal paracetamol concentration (Cmax), time to Cmax (Tmax), area under the curve (AUC) and elimination half-life (t(1/2)) were compared." | 2.72 | Comparative pharmacokinetics of Panadol Extend and immediate-release paracetamol in a simulated overdose model. ( Graudins, A; Tan, C, 2006) |
| "Acetaminophen was chosen as our overdose drug because it has relatively few side effects, serum levels are easily attainable and measurable, and it is generally a common drug overdose." | 2.71 | Efficacy of superactivated charcoal administered late (3 hours) after acetaminophen overdose. ( Enoki, NR; Marn, RY; Sato, RL; Sumida, SM; Wong, JJ; Yamamoto, LG, 2003) |
| " Serum APAP concentrations (APAPs) were measured hourly from zero through eight hours and again at 24 hours, and basic noncompartmental pharmacokinetic parameters were compared." | 2.71 | Pharmacokinetic effects of diphenhydramine or oxycodone in simulated acetaminophen overdose. ( Goklaney, A; Halcomb, SE; Mullins, ME; Sivilotti, ML, 2005) |
| "Acetaminophen may have been blunted some adverse effects." | 2.70 | Adverse effects of superactivated charcoal administered to healthy volunteers. ( Sato, RL; Sumida, SM; Wong, JJ; Yamamoto, LG, 2002) |
| "Oral activated charcoal is used to treat drug overdose and is effective at reducing drug absorption when administered within 1 h of drug ingestion." | 2.69 | Effectiveness of delayed activated charcoal administration in simulated paracetamol (acetaminophen) overdose. ( Thomas, SH; Yeates, PJ, 2000) |
| "The purpose of this trial was to compare the pharmacokinetics of the two available acetaminophen dosage forms in simulated human overdose." | 2.68 | Pharmacokinetics of extended relief vs regular release Tylenol in simulated human overdose. ( Goldfrank, L; Hoffman, RS; Howland, MA; Kaplan, L; Rees, S; Stork, CM, 1996) |
| " Both the AUC and the Cmax were less after ER APAP than after IR APAP; otherwise, there was no evident difference in any measure." | 2.68 | A pharmacokinetic comparison of acetaminophen products (Tylenol Extended Relief vs regular Tylenol) ( Douglas, DR; Sholar, JB; Smilkstein, MJ, 1996) |
| "To determine the absorption rate of a supratherapeutic dose of acetaminophen elixir and compare the effect of activated charcoal (AC) given at different time intervals on preventing acetaminophen absorption." | 2.67 | Simulated acetaminophen overdose: pharmacokinetics and effectiveness of activated charcoal. ( Gorman, RL; Klein-Schwartz, W; Oderda, GM; Rose, SR; Watson, WA, 1991) |
| "Pulmonary mucormycosis is a highly lethal invasive fungal infection usually found in immunocompromised patients." | 2.66 | Pulmonary mucormycosis in a patient with acute liver failure: A case report and systematic review of the literature. ( Carrier, FM; Chapdelaine, H; Huang, YQ; Luong, ML; Tremblay, JA, 2020) |
| "Fomepizole (4-methylpyrazole) is safe and has shown efficacy in preclinical models, human hepatocytes and in volunteers against APAP overdose." | 2.66 | Novel strategies for the treatment of acetaminophen hepatotoxicity. ( Akakpo, JY; Jaeschke, H; Ramachandran, A, 2020) |
| "Acetaminophen (APAP) is a highly effective analgesic, which is safe at therapeutic doses." | 2.61 | Acetaminophen hepatotoxicity: A mitochondrial perspective. ( Jaeschke, H; Ramachandran, A, 2019) |
| "Prazosin's increase in popularity as a treatment for posttraumatic stress disorder makes it important for emergency physicians to be aware of how to manage potential toxic ingestion because of prazosin overdose." | 2.58 | Refractory Hypotension Caused by Prazosin Overdose Combined With Acetaminophen and Naproxen Toxicity: A Case Report and Review of the Literature. ( Anderson, C; Gupta, R; Lim, RK; Lynch, T, 2018) |
| "Acute liver failure is a rare but life-threatening medical emergency in pregnancy whose true incidence remains unknown." | 2.53 | Liver Failure in Pregnancy. ( Bacak, SJ; Thornburg, LL, 2016) |
| "Acetaminophen is a commonly used pediatric medication that has recently been approved for intravenous use in the United States." | 2.52 | Intravenous acetaminophen use in pediatrics. ( Shastri, N, 2015) |
| " One notable exception is acetaminophen (APAP, paracetamol), which is a safe drug at therapeutic doses but can cause severe liver injury and acute liver failure after intentional and unintentional overdoses." | 2.52 | Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients. ( Jaeschke, H, 2015) |
| " Specific and sensitive detection of liver injury is important for the prompt and safe treatment of patients with the antidote N-acetylcysteine (NAC) and for the determination of NAC efficacy." | 2.50 | Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges. ( Antoine, DJ; Dear, JW, 2014) |
| "Acetaminophen is a commonly-used analgesic in the US and, at doses of more than 4 g/day, can lead to serious hepatotoxicity." | 2.50 | A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States. ( Ben-Joseph, R; Blieden, M; Paramore, LC; Shah, D, 2014) |
| "Acetaminophen (paracetamol) is a widely used nonopioid, non-NSAID analgesic that is effective against a variety of pain types, but the consequences of overdose can be severe." | 2.50 | Acetaminophen (paracetamol) oral absorption and clinical influences. ( Decker, JF; Patrick, JT; Pergolizzi, JV; Raffa, RB; Taylor, R, 2014) |
| "A 14-year-old girl with systemic lupus erythematosus presented with a mixed overdose of paracetamol, ibuprofen and azathioprine (1500 mg) following a deliberate self-harm attempt." | 2.49 | Intentional overdose of azathioprine in a patient with systemic lupus erythematosus. ( Khan, AM; Mahmood, K; Martin, K; Ramanan, AV, 2013) |
| " This drug is, however, effective and safe if notes of caution are applied." | 2.49 | [Paracetamol. Efficacious and safe for all ages]. ( Wehling, M, 2013) |
| " Formalized pharmacokinetic studies of piperacillin/tazobactam removal in patients on MARS therapy are necessary to make clear dosing recommendations." | 2.49 | Molecular Adsorbent Recirculating System (MARS(®)) removal of piperacillin/tazobactam in a patient with acetaminophen-induced acute liver failure. ( Argento, AC; Heavner, MS; Ruggero, MA; Topal, JE, 2013) |
| " This commentary addresses the reasons for this, and the background to choice of dose of acetylcysteine utilized in the oral and IV dosing regimens." | 2.48 | Acetaminophen and acetylcysteine dose and duration: past, present and future. ( Bateman, DN; Rumack, BH, 2012) |
| "Acetaminophen is a leading cause of overdose-related hepatotoxicity." | 2.47 | Intravenous acetylcysteine for the treatment of acetaminophen overdose. ( Doyon, S; Klein-Schwartz, W, 2011) |
| " Practitioners should caution patients to follow recommended dosage instructions and avoid taking multiple APAP-containing products." | 2.47 | The therapeutic applications of and risks associated with acetaminophen use: a review and update. ( Guggenheimer, J; Moore, PA, 2011) |
| "Adults who received repeated dosing of acetaminophen 4 g/day or lower for at least 24 hours." | 2.44 | Does therapeutic use of acetaminophen cause acute liver failure? ( Bailey, E; Dart, RC, 2007) |
| "Acetaminophen is a commonly used antipyretic and analgesic agent." | 2.44 | Acetaminophen hepatotoxicity. ( Larson, AM, 2007) |
| "Paracetamol poisoning is implicated in about 150-200 poisoning deaths per year in England and Wales." | 2.43 | Restricting paracetamol in the United Kingdom to reduce poisoning: a systematic review. ( Majeed, A; Morgan, O, 2005) |
| " In addition, the Toxic Exposure Surveillance System (TESS) of the American Association of Poison Control Centers (AAPCC) database was searched for human exposure cases." | 2.43 | The safety profile of sustained release paracetamol during therapeutic use and following overdose. ( Bogdan, GM; Dart, RC; Green, JL, 2005) |
| " Dosing of both drug groups is tempered by concerns about toxicity." | 2.43 | Pain control: non-steroidal anti-inflammatory agents. ( Anderson, BJ; Jacqz-Aigrain, E, 2006) |
| "The safety of paracetamol when given in the recommended dosage is well documented." | 2.43 | Repeated supratherapeutic doses of paracetamol in children--a literature review and suggested clinical approach. ( Berkovitch, M; Greenberg, R; Kozer, E; Zimmerman, DR, 2006) |
| " Dosing errors and hyponatremia have occurred in pediatric patients receiving i." | 2.43 | Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning. ( Kanter, MZ, 2006) |
| "The currently recommended dosing scheme for treating acetaminophen overdose in the United States consists of a loading dose of oral N-acetylcysteine 140 mg/kg, followed by 70 mg/kg every 4 hours for 17 doses, for a total of 72 hours of oral N-acetylcysteine therapy." | 2.42 | Acetaminophen intoxication and length of treatment: how long is long enough? ( Kociancic, T; Reed, MD, 2003) |
| " As is true for most all potentially beneficial medicines used in pediatrics, awareness of the actual amount of drug received from all sources and caution to not exceed the age-appropriate dosing guidelines (i." | 2.41 | Acetaminophen intoxication during treatment: what you don't know can hurt you. ( Kearns, GL; Leeder, JS; Wasserman, GS, 2000) |
| " Proposed risk factors for injury with chronic use include age, total dose, duration, presence of intercurrent febrile illness, starvation, co-administration of cytochrome P450-inducing drugs, underlying hepatic disease, and unique genetic makeup." | 2.41 | Chronic acetaminophen overdosing in children: risk assessment and management. ( Bond, GR; Sztajnkrycer, MJ, 2001) |
| " Serum acetaminophen levels for which an estimate of time from last dose could be calculated were available for 30 patients, of which 22 levels were greater than the toxic range described for acute ingestion." | 2.40 | Therapeutic misadventures with acetaminophen: hepatoxicity after multiple doses in children. ( Barbacci, MB; Heubi, JE; Zimmerman, HJ, 1998) |
| "Clinical descriptions of fulminant hepatic failure as originally reported, along with the subgroups of subfulminant and late onset hepatic failure identified later, are considered in relation to the proposed new classification of hyperacute, acute, and subacute liver failure." | 2.39 | Classification, etiology, and considerations of outcome in acute liver failure. ( Williams, R, 1996) |
| " Clinical trial evidence supporting shorter NAC dosing now allows the possibility for intensifying treatment without the risk of very high rates of ADRs." | 1.91 | Large paracetamol overdose-Higher dose acetylcysteine is required. ( Bateman, DN, 2023) |
| "Acetaminophen overdose is a leading cause of liver failure, and a leading cause of pediatric poisoning requiring hospital admission." | 1.91 | Comparison of Two-Bag Versus Three-Bag N-Acetylcysteine Regimens for Pediatric Acetaminophen Toxicity. ( Camarena-Michel, A; Hoyte, C; Leonard, J; Pennington, S; Sudanagunta, S; Wang, GS, 2023) |
| "Fomepizole is a promising new treatment for preventing liver injury following paracetamol (acetaminophen) overdose." | 1.91 | Fomepizole should not be used more liberally in paracetamol overdose. ( Dear, JW, 2023) |
| "During the outbreak of COVID19 measures taken to contain the spread of the virus have influenced the mental well-being of adults and adolescents." | 1.91 | Early treatment with N-acetylcysteine reduces hepatotoxicity in acute acetaminophen poisoning. ( Capossela, L; Chiaretti, A; Curatola, A; Ferretti, S; Gatto, A; Graglia, B; Pansini, V, 2023) |
| "To assess the safety of dosing more than 4 grams of acetaminophen in a 24-hour period in hospitalized patients and develop a method to evaluate the ongoing practice of acetaminophen dosing." | 1.91 | A Retrospective Review of Hospitalized Patients Receiving a Higher than Maximum Dose of Acetaminophen. ( Clark, AT; Clark, RF; Derry, K; Miller, M; Minns, AB; Stevens, C, 2023) |
| "Fomepizole has proven safety in methanol and ethylene glycol poisoning and is a potent CYP2E1 and c-Jun-N-terminal Kinase (JNK) inhibitor that is effective even in the metabolic phase." | 1.72 | Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. ( Link, SL; Osmon, S; Rampon, G; Rumack, BH; Scalzo, AJ, 2022) |
| " RNA-sequencing analysis suggested that Utx deficiency in female mice upregulated antitoxic phase II conjugating enzymes, including sulfotransferase family 2 A member 1 (Sult2a1), thus reduces the amount of toxic APAP metabolites in injured liver; while Utx deficiency also alleviated ER stress through downregulating transcription of ER stress genes including Atf4, Atf3, and Chop." | 1.72 | Histone demethylase UTX aggravates acetaminophen overdose induced hepatotoxicity through dual mechanisms. ( Chen, H; Chen, X; Huang, K; Huang, Y; Wang, Q; Wu, D; Xie, Y; Xiong, M; Yang, D; Zheng, L, 2022) |
| " We identified a mechanism by which acetaminophen overdose causes an increase in bile acid concentrations (to above toxic thresholds) in hepatocytes." | 1.72 | Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity. ( Akakpo, JY; Begher-Tibbe, B; Brackhagen, L; Brecklinghaus, T; Canbay, A; Copple, IM; Curry, SC; Friebel, A; Ghallab, A; Goldring, C; González, D; Hassan, R; Hengstler, JG; Hobloss, Z; Hoehme, S; Hofmann, U; Jaeschke, H; Kappenberg, F; Longerich, T; Luedde, T; Marchan, R; Murad, W; Myllys, M; Olyaee, M; Overbeck, N; Rahnenführer, J; Reinders, J; Schreiter, T; Seddek, AL; Sezgin, S; Sowa, JP; Trauner, M; Urban, S; Vucur, M; Zühlke, S, 2022) |
| "Acetaminophen was the most common agent reported." | 1.72 | The Toxicology Investigators Consortium Case Registry-the 2021 Annual Report. ( Aldy, K; Brent, J; Campleman, SL; Farrugia, LA; Kang, AM; Karshenas, DL; Li, S; Love, JS; Nguyen, H; Spyres, MB; Wax, PM, 2022) |
| " Genetic variation associated with acetaminophen-induced alanine aminotransferase elevation during therapeutic dosing has not been examined." | 1.72 | Genetic variants associated with ALT elevation from therapeutic acetaminophen. ( Arriaga Mackenzie, I; Dart, RC; Heard, KJ; Kaiser, S; Monte, AA; Pattee, J; Reynolds, KM; Rumack, B; Willems, E, 2022) |
| " We examined the APAP overdose pharmacokinetic (PK) profiles to assess the role of dose, coingestants and formulation: immediate release (IR), extended release (ER), and modified release (MR) on APAP pharmacokinetic measures." | 1.72 | Population pharmacokinetic analysis of acetaminophen overdose with immediate release, extended release and modified release formulations. ( Brittain, S; Dart, RC; Reynolds, K; Spyker, DA; Yarema, M; Yip, L, 2022) |
| "Although N-acetyl-cysteine (NAC) has long been used for the treatment of acetaminophen poisoning/overdose, the optimal NAC dosing regimen for varying patterns or severity of the poisoning/overdose is still unknown." | 1.72 | Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens. ( Janković, SM, 2022) |
| " We aimed to develop a population pharmacokinetic (PK) model for immediate-release (IR) and MR paracetamol and its major metabolism, and quantitatively understand the formulation difference in toxicity assessment based on the nomogram line." | 1.72 | Population pharmacokinetics of immediate-release and modified-release paracetamol and its major metabolites in a supratherapeutic dosing study. ( Chiew, AL; Duffull, SB; Isbister, GK; Li, J, 2022) |
| "Anaphylactoid reactions are well-documented adverse events associated with the intravenous administration of N-acetylcysteine (NAC) in patients with acetaminophen overdose." | 1.62 | A Case Report of a Severe, Unusually Delayed Anaphylactoid Reaction to Intravenous N-Acetylcysteine During Treatment of Acute Acetaminophen Toxicity in an Adolescent. ( Cao, DJ; Epperson, LC; Weiss, ST, 2021) |
| " This was compared with the patients for which the e-agent had, during the same period, prospectively made an alert for absolute or relative overdosing or for a dosing interval < 4 h (potentially leading to an absolute overdose)." | 1.62 | Implementation and outcome of an electronic tool for detection of paracetamol overdose in a tertiary care hospital. ( Blum, K; Cabrera-Diaz, F; Lim, S; Salili, AR; Zaugg, C, 2021) |
| " We illustrate that insufficient sulfation leads to a shift in biotransformation of paracetamol to toxic oxidation pathways and patients with low sulfate reserves are at higher risk of paracetamol toxicity." | 1.62 | Sulfate conjugation may be the key to hepatotoxicity in paracetamol overdose. ( Chiew, AL; Duffull, SB; Isbister, GK; Li, J, 2021) |
| "Recent recognition of "massive" acetaminophen (APAP) overdoses has led to the question of whether standard dosing of N-acetylcysteine (NAC) is adequate to prevent hepatoxicity in these patients." | 1.62 | Clinical outcome of massive acetaminophen overdose treated with standard-dose N-acetylcysteine. ( Cumpston, KL; Downs, JW; Kershner, EK; Rose, SR; Troendle, MM; Wills, BK, 2021) |
| "Acetaminophen is a common cause of intentional and inadvertent overdoses among children and adolescents worldwide." | 1.62 | Clinical Characteristics, Outcomes, Disposition, and Acute Care of Children and Adolescents Treated for Acetaminophen Toxicity. ( Bostwick, JM; Lewis, CP; Romanowicz, M; Shekunov, J; Vande Voort, JL, 2021) |
| "Imperatorin (IMP) is a furanocoumarin from Angelica dahurica, which has antioxidant and anti-inflammatory effects." | 1.56 | The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury. ( Chang, Y; Cheng, B; Gao, W; Gao, Y; Gao, Z; Liu, C; Miao, W; Song, C; Wei, L; Williams, K; Xu, Q; Yang, X; Yang, Z; Zhang, J; Zhang, Y, 2020) |
| "Acute liver failure is a rare syndrome and is primarily caused by paracetamol toxicity in developed nations." | 1.56 | Acute liver failure. ( Arshad, MA; Bangash, MN; Murphy, N, 2020) |
| " With the increasing administration of intravenous (IV) paracetamol, there will be the associated risk of medication dosing errors." | 1.51 | Intravenous Paracetamol Overdose: A Pediatric Case Report. ( Arslan, D; Aslan, N; Bilen, S; Horoz, OO; Yildizdas, D; Yilmaz, HL, 2019) |
| " Functional experiments showed that OPN deficiency protected against the APAP-induced liver injury by inhibiting the toxic APAP metabolism via reducing the expression of the cytochrome P450 family 2 subfamily E member 1 (CYP2E1)." | 1.51 | Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin. ( Gu, J; Kong, X; Sun, X; Sun, Y; Tong, Y; Wang, C; Wang, K; Wen, Y; Wu, H; Xia, Q; Yu, C, 2019) |
| "Dihydrocodeine and tramadol are particularly toxic in overdose and codeine is also relatively toxic." | 1.51 | Relative toxicity of analgesics commonly used for intentional self-poisoning: A study of case fatality based on fatal and non-fatal overdoses. ( Bankhead, C; Casey, D; Clements, C; Ferrey, A; Fuller, A; Geulayov, G; Gunnell, D; Hawton, K; Kapur, N; Ness, J; Wells, C, 2019) |
| "Acetaminophen was undetectable in serum samples from 227 patients (52%)." | 1.51 | Acetaminophen is Undetectable in Plasma From More Than Half of Patients Believed to Have Acute Liver Failure Due to Overdose. ( Gottfried, M; Hameed, B; Lee, WM; Leventhal, TM; Olson, JC; Subramanian, RM, 2019) |
| "Temporal patterns of acetaminophen use exceeding the recommended daily maximum dosage of 4 g over a 5-year period (4/1/2011-3/31/2016) were evaluated in an online 1-week diary study of 14 434 adult acetaminophen users who also reported acetaminophen use in the previous month." | 1.51 | Five-year trends in acetaminophen use exceeding the recommended daily maximum dose. ( Battista, DR; Kaufman, DW; Kelly, JP; Malone, MK; Shiffman, S; Weinstein, RB, 2019) |
| " The relationship between alanine aminotransferase (ALT) activity and APAP-CYS concentration might assist in distinguishing between toxic and non-toxic APAP doses in patients suspected of drug overdose." | 1.51 | The Relationship Between Circulating Acetaminophen-Protein Adduct Concentrations and Alanine Aminotransferase Activities in Patients With and Without Acetaminophen Overdose and Toxicity. ( Curry, SC; Gerkin, RD; Jaeschke, H; Kang, AM; O'Connor, AD; Padilla-Jones, A; Ruha, AM; Wilhelms, K; Wilkins, DG, 2019) |
| " Graphical analysis, descriptive statistics and population pharmacokinetic modelling were used to describe data." | 1.48 | The standard treatment protocol for paracetamol poisoning may be inadequate following overdose with modified release formulation: a pharmacokinetic and clinical analysis of 53 cases. ( Brogren, J; Salmonson, H; Sjöberg, G, 2018) |
| "Acetylcysteine (NAC), an effective antidote for paracetamol poisoning, is commonly associated with adverse reactions." | 1.48 | Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose. ( Chandru, P; Gunja, N; Lim, JME; McNulty, R, 2018) |
| "The primary outcome was any anaphylactoid reaction, defined as cutaneous (urticaria, pruritus, angioedema) or systemic (hypotension, respiratory symptoms)." | 1.48 | Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning. ( Bailey, B; Chopra, P; Gosselin, S; Johnson, D; Nettel-Aguirre, A; Purssell, R; Rumack, B; Sivilotti, MLA; Spyker, D; Thompson, M; Victorino, C; Yarema, M, 2018) |
| "Patients with cystic fibrosis are more likely to have glutathione deficiency, and greater susceptibility to liver injury." | 1.48 | Hepatotoxicity after paracetamol overdose in a patient with cystic fibrosis despite early acetylcysteine and utility of microRNA to predict hepatotoxicity. ( Cheung, B; Gantier, M; Graudins, A; Nejad, C; Wong, A, 2018) |
| "Early survivors (acute liver failure patients who survived 90 days after the ICU admission) were assessed for long-term outcomes in four distinctive cohorts, incorporating aetiology (Acetaminophen overdose or non-Acetaminophen overdose), and management strategy (conservative or liver transplantation)." | 1.48 | Long-term outcome in patients with acute liver failure. ( Agarwal, B; Alabsawy, E; Figorilli, F; Jalan, R; Putignano, A, 2018) |
| "Acetaminophen is a common cause of acute liver failure in pediatrics." | 1.48 | A case report of full recovery from severe cerebral edema secondary to acetaminophen-induced hepatotoxicity in a 13 year old girl. ( Austin, EB; Crouse, BA; Hobbs, H; Lobos, AT, 2018) |
| "We performed pharmacokinetic simulations using Berkeley Madonna (version 8." | 1.46 | Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning. ( Graudins, A; Landersdorfer, C; Wong, A, 2017) |
| "Toxic myocarditis is an extremely rare complication of acetaminophen overdose." | 1.46 | Toxic Myocarditis Caused by Acetaminophen in a Multidrug Overdose. ( Crahes, M; Dazé, Y; Gosselin, M; Mireault, P, 2017) |
| " In 2012, the UK Commission on Human Medicines made recommendations for the management of paracetamol overdose, including provision of weight-based acetylcysteine dosing tables." | 1.46 | An assessment of the variation in the concentration of acetylcysteine in infusions for the treatment of paracetamol overdose. ( Archer, JR; Bailey, GP; Dargan, PI; Flanagan, RJ; Rab, E; Wood, DM, 2017) |
| "Acetaminophen toxicity is a common cause of pediatric liver failure." | 1.46 | Serum Acetaminophen Protein Adduct Concentrations in Pediatric Emergency Department Patients. ( Anderson, V; Dart, RC; Green, JL; Heard, K; Kile, D; Lavonas, EJ, 2017) |
| "Baicalin treatment significantly attenuated the elevation of liver ALT levels, as well as hepatic MPO activity in a dose- dependent manner (15-60[Formula: see text]mg/kg) in APAP-treated mice." | 1.46 | ERK Signaling Pathway Plays a Key Role in Baicalin Protection Against Acetaminophen-Induced Liver Injury. ( Chou, AH; Day, YJ; Lee, HC; Liao, CC; Liou, JT; Liu, FC, 2017) |
| "Acute liver failure is a rare and devastating clinical condition resulting from sudden loss of hepatic parenchyma and metabolic function." | 1.46 | Acute liver failure in Scotland: changes in aetiology and outcomes over time (the Scottish Look-Back Study). ( Baird, A; Davidson, JS; Donnelly, MC; Hayes, PC; Martin, K; Simpson, KJ, 2017) |
| "Simulations of paracetamol time course concentrations in the blood were in close agreement with experimental data under a wide range of dosing conditions." | 1.43 | A novel approach for estimating ingested dose associated with paracetamol overdose. ( Heard, K; Reisfeld, B; Zurlinden, TJ, 2016) |
| "The goal of this study is to summarize trends in rates of adverse events attributable to acetaminophen use, including hepatotoxicity and mortality." | 1.43 | Trends in rates of acetaminophen-related adverse events in the United States. ( Ding, Y; Iyasu, S; Major, JM; Mehta, H; Pham, TM; Staffa, JA; Trinidad, JP; Wang, C; Willy, ME; Wong, HL; Zhou, EH, 2016) |
| "Acetaminophen is a commonly used analgesic/antipyretic; overdoses can lead to liver damage." | 1.43 | Relation of Health Literacy to Exceeding the Labeled Maximum Daily Dose of Acetaminophen. ( Battista, DR; Kaufman, DW; Kelly, JP; Malone, MK; Shiffman, S; Weinstein, RB, 2016) |
| "Acetaminophen was discontinued and IV acetylcysteine was given and continued at the second maintenance dose rate for a second 16-hour infusion, at which time transaminases, INR, ammonia and total bilirubin were all improving." | 1.43 | Acute hepatotoxicity associated with therapeutic doses of intravenous acetaminophen. ( Anderson, VE; Dart, RC; Green, JL; Heard, KJ; Kovnat, D; Seifert, SA, 2016) |
| "Acetaminophen was involved in 81 (6." | 1.43 | Medication Overdoses at a Public Emergency Department in Santiago, Chile. ( Aguilera, P; Basaure, C; Garrido, M; Lara, B; Lessard, E; Mallon, WK; Saldias, F; Swadron, SP; Swanson, J, 2016) |
| " This dose-response relationship between paracetamol concentration and ALI persisted even in patients treated with NAC within 8 h of overdose (nomogram 0-100: 0%, 101-150: 0." | 1.43 | Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteine. ( Al-Hourani, K; Bateman, DN; Beckwith, HK; Cairney, DG; Dear, JW; Eddleston, M, 2016) |
| " Exposure of healthy male Swiss mice to a toxic overdose of APAP (350 mg/kg, ip) significantly increased serum hepatocellular enzyme activities, decreased hepatocellular glutathione (GSH) levels, and induced severe centrilobular hepatocellular necrosis." | 1.43 | Elucidation of the hepatoprotective moiety of 5β-scymnol that suppresses paracetamol toxicity in mice. ( Carter, F; Hodges, LD; Kalafatis, N; Macrides, TA; Wright, PF, 2016) |
| "Paracetamol cardiotoxicity has rarely been clinically significant and may have well been overlooked." | 1.43 | A study on paracetamol cardiotoxicity. ( Dissanayake, AM; Ekanayake, EM; Jayawickreme, KP; Ralapanawa, U, 2016) |
| "Acetaminophen overdose is a leading cause of drug-induced liver failure in the United States." | 1.43 | Detection of Acetaminophen-Protein Adducts in Decedents with Suspected Opioid-Acetaminophen Combination Product Overdose. ( Andrenyak, DM; Curry, SC; Grey, TC; McGill, LD; Rollins, DE; Thomas, KC; Wilkins, DG, 2016) |
| "Acetaminophen may cause liver damage with dose-dependent manner." | 1.43 | [A Case of Acetaminophen Poisoning Associated with Tramcet Overdose]. ( Egashira, T; Fukusaki, M; Goto, S; Terao, Y; Tuji, T; Urabe, S, 2016) |
| "Naloxone was the most frequently administered treatment (n=137, 7." | 1.43 | Non-accidental non-fatal poisonings attended by emergency ambulance crews: an observational study of data sources and epidemiology. ( John, A; Moore, C; Okolie, C; Oretti, R; Porter, A; Snooks, H; Thomas, G; Whitfield, R, 2016) |
| "22." | 1.42 | Epidemiology, management and outcome of paracetamol poisoning in an inner city emergency department. ( Benger, J; Bramley, K; Carroll, R; Griffin, L; Gunnell, D; Potokar, J; Williams, S, 2015) |
| " Despite being safe at therapeutic doses, an accidental or intentional overdose can result in severe hepatotoxicity; a leading cause of drug-induced liver failure in the U." | 1.42 | Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells. ( Ercal, N; Fan, W; Khayyat, A; Tobwala, S, 2015) |
| "We wondered whether renal failure would affect APAP-CYS elimination half-life and whether continuous venovenous hemodiafiltration (CVVHDF), commonly used in liver failure patients, would remove adducts to lower their serum concentrations." | 1.42 | Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose. ( Bikin, DS; Curry, SC; Gerkin, RD; O'Connor, AD; Padilla-Jones, A; Rollins, DE; Ruha, AM; Slawson, MH; Wilkins, DG, 2015) |
| "Previous studies in patients with acute liver failure identified acetaminophen (APAP) protein adducts in the serum of 12% and 19% of children and adults, respectively, with acute liver failure of indeterminate etiology." | 1.42 | Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure. ( Alonso, EM; James, LP; Squires, RH; Zhang, S, 2015) |
| " If asked about medications, the SP portraying a parent was trained to disclose that she was administering acetaminophen and to produce a package with dosing instructions on the label." | 1.42 | Can medical students identify a potentially serious acetaminophen dosing error in a simulated encounter? a case control study. ( Barone, MA; Dudas, RA, 2015) |
| " We show that for the rat chronically dosed with dexamethasone (an artificial glucocorticoid which induces a catabolic state) the model can be used to explain empirically observed facts such as the linear decline in intramuscular Gln and the drop in plasma glutamine." | 1.42 | The role of skeletal muscle in liver glutathione metabolism during acetaminophen overdose. ( Bilinsky, LM; Nijhout, HF; Reed, MC, 2015) |
| "14%) with acute poisoning at toxic doses showed hepatotoxicity signs, 4 (57." | 1.42 | Hepatotoxicity induced by acute and chronic paracetamol overdose in adults. Where do we stand? ( Borobia, AM; Carcas, AJ; Frías, J; García, S; Martín, J; Martínez, AM; Medrano, N; Quintana, M; Ramírez, E; Ruiz, JA; Tong, HY, 2015) |
| "Acetaminophen is a widespread and commonly used painkiller all over the world." | 1.42 | Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity. ( Reddyhoff, D; Regan, S; Ward, J; Webb, S; Williams, D, 2015) |
| "In Australia, legislation requires medication containing paracetamol display warning of co-administration with other paracetamol products, and safe maximum daily dosing (4 g)." | 1.42 | High-visibility warning labels on paracetamol-containing products do not prevent supratherapeutic ingestion in a simulated scenario. ( Greene, S; Howell, J; Robotham, A; Rotella, JA; Wong, A, 2015) |
| " Fits of synthetic data derived from chronic use overdose scenarios to MALD lead to accurate predictions of outcome, even when liver injury is the result of sustained overuse." | 1.40 | Mathematical modelling of chronic acetaminophen metabolism and liver injury. ( Adler, FR; Remien, CH; Sussman, NL, 2014) |
| "Acetaminophen (APAP) is a widely used analgesic." | 1.40 | Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans. ( Curry, SC; Jaeschke, H; Li, F; Ma, X; McGill, MR; Sharpe, MR; Williams, CD, 2014) |
| "Acute dental pain is a recognised precipitant of unintentional paracetamol overdose and in a small but significant number of cases this results in hepatotoxicity." | 1.40 | Identifying adults at risk of paracetamol toxicity in the acute dental setting: development of a clinical algorithm. ( Byers, J; Marney, C; Nayyer, NV, 2014) |
| "Paracetamol-induced haemolysis in G6PD deficiency is a rare complication and mostly reported in children." | 1.40 | Glucose-6-phosphate dehydrogenase deficiency: an unusual cause of acute jaundice after paracetamol overdose. ( Phillpotts, S; Sen, S; Tash, E, 2014) |
| " A model based on pharmacokinetic parameters was developed to predict 4-h acetaminophen concentration for this and other ingested doses." | 1.40 | Four-hour acetaminophen concentration estimation after ingested dose based on pharmacokinetic models. ( Gosselin, S; Villeneuve, E; Whyte, I, 2014) |
| " Since some of these dosing errors are the result of system design flaws, analysis of large overdoses can lead to the discovery of needed system changes." | 1.40 | Analysis of electronic medication orders with large overdoses: opportunities for mitigating dosing errors. ( Kirkendall, ES; Kouril, M; Minich, T; Spooner, SA, 2014) |
| "Acetaminophen Psi Nomogram is a sensitive and specific tool for prediction of hepatotoxicity secondary to acute acetaminophen overdose." | 1.40 | Acetaminophen Psi Nomogram: a sensitive and specific clinical tool to predict hepatotoxicity secondary to acute acetaminophen overdose. ( Chomchai, C; Chomchai, S; Lawattanatrakul, N, 2014) |
| "Acetaminophen overdose is a major concern among the pediatric population." | 1.39 | Validation of ICD-9-CM codes for identification of acetaminophen-related emergency department visits in a large pediatric hospital. ( de Achaval, S; Feudtner, C; Palla, S; Suarez-Almazor, ME, 2013) |
| " Forty-six parents (32%) had an acetaminophen dosing error." | 1.39 | Parental language and dosing errors after discharge from the pediatric emergency department. ( Porter, SC; Samuels-Kalow, ME; Stack, AM, 2013) |
| " The prognostic value of patient-reported dosage cut-offs of 8, 10 and 12 g was determined." | 1.38 | Reliability of the reported ingested dose of acetaminophen for predicting the risk of toxicity in acetaminophen overdose patients. ( Awang, R; Sulaiman, SA; Zyoud, SH, 2012) |
| "To study the proportion of APAP users potentially consuming APAP over the currently recommended dosage (4 g/day) and a toxic dosage (10 g/day)." | 1.38 | Prescription-acquired acetaminophen use and potential overuse patterns: 2001-2008. ( Gokhale, M; Martin, BC, 2012) |
| "Both delayed presentation and staggered overdose pattern are associated with adverse outcomes following paracetamol overdose." | 1.38 | Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity. ( Bates, CM; Craig, DG; Davidson, JS; Hayes, PC; Martin, KG; Simpson, KJ, 2012) |
| " Experience from Europe indicates that serious dosing errors are likely to occur." | 1.38 | Intravenous acetaminophen in the United States: iatrogenic dosing errors. ( Dart, RC; Rumack, BH, 2012) |
| "Acetaminophen overdose was significantly more common in female subjects than in male subjects (aPR = 3." | 1.38 | Acetaminophen overdose in the Military Health System. ( Coster, TS; Meyer, TE; Taylor, LG; Xie, S, 2012) |
| " A recent study highlighted the risk of overdose of paracetamol using British National Formulary for Children (BNFC) age-based dosing guidelines." | 1.38 | Proposed MHRA changes to UK children's paracetamol dosing recommendations: modelling study. ( Beasley, R; Eyers, S; Fingleton, J; Perrin, K, 2012) |
| "2 % made serious errors by dosing out more than six grams." | 1.38 | Risk of unintentional overdose with non-prescription acetaminophen products. ( Bailey, SC; Davis, TC; Di Francesco, L; Jacobson, K; King, J; McCarthy, D; Mullen, R; Parker, RM; Serper, M; Wolf, MS, 2012) |
| " The extent of errors of dosage was within the intervals [90-120 mg/kg/d] and greater than 120 mg/kg/d for 87 and 11 patients respectively, who were prescribed a single non-combination paracetamol containing product." | 1.38 | Overdosed prescription of paracetamol (acetaminophen) in a teaching hospital. ( Allenet, B; Charpiat, B; Henry, A; Leboucher, G; Tod, M, 2012) |
| "001), or with accidental toxic exposure (90% older, 29% younger, P < 0." | 1.38 | Characteristics of older and younger patients with suspected paracetamol toxicity. ( Carroll, PR; Hilmer, SN; Kane, A; Matthews, S; Mitchell, SJ, 2012) |
| "Acetaminophen is a commonly used analgesic; excessive doses can lead to liver damage." | 1.38 | Prevalence and correlates of exceeding the labeled maximum dose of acetaminophen among adults in a U.S.-based internet survey. ( Kaufman, DW; Kelly, JP; Malone, MK; Rohay, JM; Shiffman, S; Weinstein, RB, 2012) |
| "Poisonings were classified according to the International Classification of Diseases, 10th revision, diagnostic codes ranging from T36-T65." | 1.38 | Unintentional paediatric poisoning in rural Victoria: incidence and admission rates. ( Cheng, DR; Ip, CC, 2012) |
| "Acetaminophen is a commonly used analgesic and has been shown to be a main cause of drug-induced liver failure." | 1.37 | Late extensive intravenous administration of N-acetylcysteine can reverse hepatic failure in acetaminophen overdose. ( Mehrpour, O; Sanaei-Zadeh, H; Shadnia, S, 2011) |
| "Acetaminophen appears to cause a concentration-dependent reduction of potassium concentrations and an elevation of creatinine concentrations of short duration (<24 h) after overdose." | 1.37 | Impact of serum acetaminophen concentration on changes in serum potassium, creatinine and urea concentrations among patients with acetaminophen overdose. ( Al-Jabi, SW; Awang, R; Sulaiman, SA; Zyoud, SH, 2011) |
| " In cases of massive acetaminophen overdose, standard acetylcysteine dosing may not be adequate." | 1.37 | Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose. ( Bagdure, D; Heard, K; Monte, A; Wang, GS, 2011) |
| "Elicit subject feedback about active ingredient and dosing information on over-the-counter (OTC) acetaminophen and elicit feedback on proposed plain-language text and icons." | 1.37 | Developing consumer-centered, nonprescription drug labeling a study in acetaminophen. ( Bailey, SC; Davis, TC; Di Francesco, L; Hedlund, LA; Jacobson, KL; King, JP; Parker, RM; Wolf, MS, 2011) |
| "Acetaminophen treatment increased both the cytosolic and mitochondria-associated P-JNK levels, but the c-jun-N-terminal kinase (JNK) signaling inhibitor SP600125 was hepatoprotective in wildtype mice only, indicating that the JNK pathway may not be critically involved in the absence of CypD." | 1.37 | Acetaminophen overdose-induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D-regulated permeability transition. ( Boelsterli, UA; LoGuidice, A, 2011) |
| "Hyperammonemia is a major contributing factor to the encephalopathy associated with liver disease." | 1.37 | Encephalopathy in acute liver failure resulting from acetaminophen intoxication: new observations with potential therapy. ( Brusilow, SW; Cooper, AJ, 2011) |
| " While dosing errors are common, in most cases, overdoses produce minimal clinical effects." | 1.37 | Massive acetylcysteine overdose associated with cerebral edema and seizures. ( Heard, K; Schaeffer, TH, 2011) |
| " This may result in dosing errors, a delay in treatment, or possibly more adverse effects - due to the use of a high dose rate for the first infusion when treatment is initiated." | 1.37 | A dosing regimen for immediate N-acetylcysteine treatment for acute paracetamol overdose. ( Coulter, CV; Duffull, SB; Isbister, GK; Shen, F, 2011) |
| " Efforts to curtail this practice may involve provision of prescriber and pharmacist education, utilization of benefit manager systems to flag excessive dosing or that require confirmation of dosing, and implementation of US FDA recommendations supported by these data." | 1.37 | Opioid-paracetamol prescription patterns and liver dysfunction: a retrospective cohort study in a population served by a US health benefits organization. ( Mort, JR; Ndehi, LN; Shiyanbola, OO; Stacy, JN; Xu, Y, 2011) |
| " Liver regeneration is a vital process for survival after a toxic insult." | 1.37 | Ringer's lactate improves liver recovery in a murine model of acetaminophen toxicity. ( Kajander, H; Koskinen, ML; Tenhunen, J; Yang, R; Zhang, S; Zhu, S, 2011) |
| "Acute renal failure is a recognized manifestation of paracetamol toxicity, but comparatively little data is available concerning its onset and duration." | 1.36 | Delayed onset of acute renal failure after significant paracetamol overdose: A case series. ( Jamie, H; Leggett, GE; Waring, WS, 2010) |
| "Through the next 5 hour seizure period and thereafter, the brain damage, liver damage enzyme values and hyperammonemia increased, particularly throughout the 3-24 h post-paracetamol period." | 1.36 | High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736). ( Anic, T; Boban Blagaic, A; Brcic, L; Coric, M; Djidic, S; Djuzel, V; Drmic, D; Ilic, S; Ivica, M; Klicek, R; Kolenc, D; Radic, B; Romic, Z; Seiwerth, S; Sever, M; Sikiric, P; Zarkovic, K; Zoricic, I; Zoricic, Z, 2010) |
| " These observations prompted us to investigate whether PGE2 plays a role in host defence to toxic effect of APAP." | 1.36 | The role of prostaglandin E2 in acute acetaminophen hepatotoxicity in mice. ( Cavar, I; Culo, F; Kelava, T; Saraga-Babić, M; Vukojević, K, 2010) |
| " The primary safety outcome was the percentage of patients with NAC-related adverse events." | 1.36 | A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose. ( Aguilera, E; Al-Helial, M; Arnold, T; Bebarta, VS; Bogdan, G; Buchanan, J; Clark, RF; Dart, R; Delgado, J; Froberg, B; Haur, W; Heard, K; Hoppe, J; Kao, L; Kokko, J; Lares, C; Lavonas, E; McDonagh, J; Mendoza, C; Mlynarchek, S; O'Malley, G; Odujebe, O; Qi, M; Rhyee, S; Stanford, C; Tan, HH; Tran, NN; Varney, S; Zosel, A, 2010) |
| "Sertraline (SSRI) was the most frequently prescribed antidepressant." | 1.36 | A cross-sectional observation of the factors associated with deliberate self-poisoning with acetaminophen: impact of gender differences and psychiatric intervention. ( Al-Jabi, SW; Awang, R; Sulaiman, SA; Zyoud, SH, 2010) |
| "Acetaminophen (APAP) is a leading cause of fatal overdose." | 1.35 | Evaluation of a urine screen for acetaminophen. ( Bosse, GN; Ingram, DN; Jortani, S; Womack, EP, 2008) |
| "In patients with massive acetaminophen ingestion, erratic absorption may occur, and toxic serum concentrations may persist beyond a standard 21-hour course of intravenous NAC therapy." | 1.35 | Acetaminophen overdose with altered acetaminophen pharmacokinetics and hepatotoxicity associated with premature cessation of intravenous N-acetylcysteine therapy. ( Hoffman, RS; Howland, MA; Nelson, LS; Smith, SW, 2008) |
| "Acetaminophen is an OTC medication and amongst the most used pain relievers." | 1.35 | [Accidental acetaminophen overdose]. ( Hamwi, I; Picksak, G; Stichtenoth, DO, 2008) |
| " A toxic dose of acetaminophen (800 mg/kg body weight intraperitoneally) induced severe abnormality in all basic parameters with apparent toxicity in liver (enlargement of hepatocytes, loss of cytoplasmic content with disruption in the hepatic plates and sinusoidal dilation) and renal tissue (glomerular damage with congestion of tubules)." | 1.35 | Effect of crude sulphated polysaccharide from brown algae against acetaminophen-induced toxicity in rats. ( Raghavendran, HR; Srinivasan, P, 2008) |
| "Dextropropoxyphene is a weak opioid analgesic, widely used as a step 2 analgesic (according to WHO classification) in combination with peripheral analgesics, mainly paracetamol." | 1.35 | Dextropropoxyphene withdrawal from a French university hospital: impact on analgesic drug consumption. ( Damase-Michel, C; Gaubert, S; Montastruc, JL; Pathak, A; Vié, M, 2009) |
| " Liver regeneration is a vital process for survival after a toxic insult, it occurs at a relative late time point after the injurious phase." | 1.35 | Prolonged treatment with N-acetylcystine delays liver recovery from acetaminophen hepatotoxicity. ( Fink, MP; He, X; Killeen, ME; Miki, K; Yang, R, 2009) |
| " The following study examined the pharmacokinetic profile and clinical associations of adducts in 53 adults with acute APAP overdose resulting in acute liver failure." | 1.35 | Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure. ( Capparelli, E; Davern, TJ; Hinson, JA; James, LP; Lee, WM; Letzig, L; Roberts, DW; Simpson, PM, 2009) |
| "Acetaminophen was the most common etiology, but LT proceeded more frequently in the non-acetaminophen cohort (acetaminophen: 45/326 patients received LT, 13." | 1.35 | The utilization of liver transplantation in the management of acute liver failure: comparison between acetaminophen and non-acetaminophen etiologies. ( Bates, CM; Garden, OJ; Hayes, PC; Henderson, NC; Lee, A; Masterton, G; Pollok, A; Simpson, KJ; Wigmore, SJ, 2009) |
| "Acetaminophen is a dose dependent hepatotoxin which is frequently associated with intentional self-harm." | 1.35 | Acetaminophen overdose in Jamaica. ( Lee, MG; Mills, MO, 2008) |
| "Paracetamol poisoning is a major health problem worldwide." | 1.35 | Limiting paracetamol pack size: has it worked in the UK? ( Bateman, DN, 2009) |
| "However, acute renal failure, although less frequent, can lead to serious metabolic complications and require hemodialysis." | 1.35 | [Acute renal failure after acetaminophen poisoning: report of three cases]. ( Allaouchiche, B; Baillon, JJ; Ber, CE; Christin, F; Hayi-Slayman, D; Hengy, B; Page, M; Rimmelé, T, 2009) |
| " Current intravenous dosing regimens may not provide enough N-acetylcysteine to effectively metabolise paracetamol to non-toxic adducts." | 1.35 | Early presentation following overdose of modified-release paracetamol (Panadol Osteo) with biphasic and prolonged paracetamol absorption. ( Chan, B; Graudins, A; Naidoo, D; Pham, HN; Salonikas, C, 2009) |
| "Acetaminophen appears to cause concentration-dependent hypokalaemia after overdose, and the pharmacological basis requires further consideration." | 1.35 | Acute acetaminophen overdose is associated with dose-dependent hypokalaemia: a prospective study of 331 patients. ( Malkowska, AM; Robinson, OD; Stephen, AF; Waring, WS, 2008) |
| " The paracetamol's absorption phase and elimination half-life appeared prolonged, with peak blood concentration occurring at 20 hours post-ingestion, requiring an extended course of intravenous N-acetylcysteine." | 1.35 | Prolonged absorption and delayed peak paracetamol concentration following poisoning with extended-release formulation. ( Buckley, NA; Roberts, DM, 2008) |
| " The dosing regimen is complex, consisting of a loading dose followed by 2 maintenance doses, each with different infusion rates." | 1.35 | Frequency of medication errors with intravenous acetylcysteine for acetaminophen overdose. ( Doyon, S; Hayes, BD; Klein-Schwartz, W, 2008) |
| "Patients with acute liver failure due to chronic paracetamol intoxication present with very high transaminase levels (> 4000 U/l), disproportionately low total bilirubin levels (< 200 micromol/l) and often hypoglycaemia." | 1.34 | [Risk of acute hepatic insufficiency in children due to chronic accidental overdose of paracetamol (acetaminophen)]. ( Draaisma, JM; Hameleers-Snijders, P; Hogeveen, M; Kramers, C; Smeitink, JA, 2007) |
| "55% of poisonings were intentional, where paracetamol and benzodiazepines were the preferred agents." | 1.34 | [A study of 355 consecutive acute poisoning cases admitted to an emergency ward at Copenhagen University Hospital, Bispebjerg in 2001]. ( Angelo, HR; Christensen, HR; Gude, AB; Hoegberg, LC; Nielsen, J; Pedersen, M, 2007) |
| "Acetaminophen was detected in both cases." | 1.34 | Acute fatal acetaminophen overdose without liver necrosis. ( Bannach, BG; Denmark, L; Jones, GR; Singer, PP, 2007) |
| " This study assessed the ability of doctors and nurses to calculate correct doses using manual calculation skills and a weight-based NAC dosing chart when prescribing and preparing NAC infusions." | 1.34 | Weight-based N-acetylcysteine dosing chart to minimise the risk of calculation errors in prescribing and preparing N-acetylcysteine infusions for adults presenting with paracetamol overdose in the emergency department. ( Calvert, SH; Cavell, G; Glucksman, E; Gonzalez, J; Kerins, M; Selvan, VA, 2007) |
| " Primary safety/tolerability endpoints included the mortality rate and incidence of adverse drug reactions, while efficacy endpoints included alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels." | 1.34 | Safety and efficacy of intravenous N-acetylcysteine for acetaminophen overdose: analysis of the Hunter Area Toxicology Service (HATS) database. ( Dawson, AH; Francis, B; Whyte, IM, 2007) |
| " Algorithms for hepatotoxicity (including codes for hepatic necrosis, toxic hepatitis and encephalopathy) and ALF (hepatic necrosis and encephalopathy) were also highly predictive (c-statistics = 0." | 1.34 | Validation of ICD-9-CM/ICD-10 coding algorithms for the identification of patients with acetaminophen overdose and hepatotoxicity using administrative data. ( Leung, Y; Li, B; Myers, RP; Shaheen, AA, 2007) |
| "Acute poisoning is a significant health problem all over the world." | 1.33 | MS 04-044: demographic features of drug and chemical poisoning in northern Malaysia. ( Ab Rahman, AF; Fathelrahman, AI; Mohd Zain, Z, 2005) |
| " We demonstrate that this non-negative area estimates the cellular burden of toxic adducts formed following overdose." | 1.33 | A new predictor of toxicity following acetaminophen overdose based on pretreatment exposure. ( Good, AM; Johnson, DW; Juurlink, DN; Sivilotti, ML; Yarema, MC, 2005) |
| "Two patients with acute renal injury died after admission." | 1.33 | Acute renal dysfunction in acetaminophen poisoning. ( Caraccio, T; Feinfeld, DA; McGuigan, M; Mour, G, 2005) |
| " The strongest predictor of severe hepatotoxicity was delayed or no N-acetyl cysteine treatment in patients consuming greater than 10 g of paracetamol or with toxic serum paracetamol levels." | 1.33 | Paracetamol overdose and hepatotoxicity at a regional Australian hospital: a 4-year experience. ( Ayonrinde, OA; Ayonrinde, OT; Hurley, JC; Phelps, GJ, 2005) |
| "Accidental or incidental paracetamol overdose in children may be associated with toxic liver damage leading to fulminant liver failure." | 1.33 | Paracetamol induced hepatotoxicity. ( Davies, P; Kelly, DA; Mahadevan, SB; McKiernan, PJ, 2006) |
| "In addition to hepatic dysfunction, renal failure and disseminated intravascular coagulopathy, we should pay attention to various symptoms like in this case when treating for a acetaminophen poisoning." | 1.33 | [Case report of repeated acetaminophen overdosing with various symptoms]. ( Inagawa, H; Ishida, J; Kojima, N; Machida, M; Okada, Y; Terada, T, 2006) |
| "To evaluate the risk of fulminant hepatic failure in relation to paracetamol overuse with therapeutic intent in febrile children." | 1.33 | Fulminant hepatic failure and paracetamol overuse with therapeutic intent in febrile children. ( Fernandopulle, BM; Fernandopulle, M; Lamabadusuriya, SP; Ranganathan, SS; Sathiadas, MG; Sumanasena, S, 2006) |
| "Meprobamate was also found as the metabolite of carisoprodol in both urine and plasma." | 1.32 | Simultaneous determination of carisoprodol and acetaminophen in an attempted suicide by liquid chromatography-mass spectrometry with positive electrospray ionization. ( Aoki, M; Maeno, Y; Matsumoto, T; Matsuoka, T; Nagao, M; Sano, T, 2003) |
| "Dextropropoxyphene poisoning is an uncommon accidental poisoning in children." | 1.32 | Accidental dextropropoxyphene poisoning. ( Hegde, SR; Karunakara, BP; Maiya, PP; Pradeep, GC, 2003) |
| "In addition to signs of acute liver failure with a systemic inflammatory response syndrome, these three previously healthy young women demonstrated cutaneous vasoconstriction." | 1.32 | Coingestion of cyclooxygenase inhibitors can worsen severe paracetamol poisoning by middle-sized and small arteries vasoconstriction. ( Assemi, P; Castelain, V; Lavigne, T; Meyer, C; Meziani, F; Neuville, A; Schneider, F, 2003) |
| "We conduct a study to determine the rate of adverse events (anaphylactoid and cardiorespiratory) associated with the use of oral N-acetylcysteine by the intravenous route for the treatment of suspected acetaminophen poisoning and to examine specific variables that may be associated with adverse events." | 1.32 | What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning? ( Brizendine, EJ; Furbee, RB; Kao, LW; Kirk, MA; Mehta, NH; Skinner, JR, 2003) |
| " Thereafter, two groups of 15 male Sprague-Dawley rats each were treated with the toxic dose of paracetamol intraperitoneally to induce severe hepatotoxicity." | 1.32 | The role of cytochrome-P450 inhibitors in the prevention of hepatotoxicity after paracetamol overdose in rats. ( Abraham, AM; Barr, S; Coetsee, C; Walubo, A, 2004) |
| "Hyperamylasaemia and even acute pancreatitis have been reported in patients with paracetamol poisoning." | 1.32 | Hyperamylasaemia and acute pancreatitis in paracetamol poisoning. ( Dalhoff, K; Schmidt, LE, 2004) |
| "This was a prospective case series of consecutive patients aged 12 years and older with acetaminophen dosage greater than 4 g per 24 hours referred to our poison center." | 1.32 | Prospective evaluation of repeated supratherapeutic acetaminophen (paracetamol) ingestion. ( Bogdan, GM; Daly, FF; Dart, RC; Heard, K; O'Malley, GF, 2004) |
| " Another 10 cases represented dosing errors with therapeutic intent (median age, 3." | 1.31 | Pediatric acetaminophen overdose: risk factors associated with hepatocellular injury. ( Alander, SW; Bratton, SL; Dowd, MD; Kearns, GL, 2000) |
| " We concluded that management of acetaminophen toxicity can be optimized by early identification, obtaining a complete drug screen, starting N-acetylcysteine early or whenever toxic acetaminophen levels or elevated transaminases are identified, and referring patients with acetaminophen toxicity to a liver center." | 1.31 | Acetaminophen hepatoxicity. ( Broughan, TA; Soloway, RD, 2000) |
| "Acetaminophen may increase International Normalized Ratio (INR) in patients taking anticoagulation medication, and in patients with acetaminophen poisoning without hepatic injury." | 1.31 | Acetaminophen causes an increased International Normalized Ratio by reducing functional factor VII. ( Buckley, NA; Dawson, AH; Goodhew, I; Reith, DM; Seldon, M; Whyte, IM, 2000) |
| " We explore the toxicities of OTC cough and cold medications, discuss mechanisms of dosing errors, and suggest why physicians should be more vigilant in specifically inquiring about OTCs when evaluating an ill child." | 1.31 | Toxicity of over-the-counter cough and cold medications. ( Gunn, VL; Liebelt, EL; Serwint, JR; Taha, SH, 2001) |
| " Although the risk of developing toxic reactions to acetaminophen appears to be lower in children than in adults, such reactions occur in pediatric patients from intentional overdoses." | 1.31 | Acetaminophen toxicity in children. ( , 2001) |
| "Patients with paracetamol-induced acute liver failure had higher Carstairs scores (1." | 1.31 | Referral patterns and social deprivation in paracetamol-induced liver injury in Scotland. ( Bathgate, AJ; Garden, OJ; Hayes, PC; Henderson, NC; Lee, A; MacGilchrist, AJ; Masterton, G; Newsome, PN; Plevris, JN; Simpson, KJ, 2001) |
| " Here, to explore its mechanism, we administered APAP at subtoxic (150 mg/kg ip) and toxic (500 mg/kg ip) doses to overnight fasted mice." | 1.31 | Genomics and proteomics analysis of acetaminophen toxicity in mouse liver. ( Pognan, F; Ruepp, SU; Shaw, J; Tonge, RP; Wallis, N, 2002) |
| "Forty-four (21." | 1.31 | Influence of acute and chronic alcohol intake on the clinical course and outcome in acetaminophen overdose. ( Bondesen, S; Christensen, E; Lee, WM; Ott, P; Schiødt, FV, 2002) |
| "There are no other reports of factor VII deficiency being identified as a result of paracetamol overdose." | 1.31 | Paracetamol poisoning unmasking factor VII deficiency. ( Chilton, AP; Elias, E; Hussain, T, 2002) |
| "Acetaminophen half-life has not been studied in patients receiving the antidote N -acetylcysteine." | 1.31 | The value of plasma acetaminophen half-life in antidote-treated acetaminophen overdosage. ( Bondesen, S; Christensen, E; Ott, P; Schiødt, FV, 2002) |
| "Peak acetaminophen levels were higher in the suicidal overdose group (mean 121." | 1.31 | Acetaminophen toxicity: suicidal vs. accidental. ( Gyamlani, GG; Parikh, CR, 2002) |
| "Drug overdose is a common method of suicide in the elderly." | 1.31 | Trends in suicide from drug overdose in the elderly in England and Wales, 1993-1999. ( Baker, A; Majeed, A; Shah, R; Uren, Z, 2002) |
| "Acetaminophen (APAP) is a common overdosed medication." | 1.31 | Utility of acetaminophen screening in unsuspected suicidal ingestions. ( Chiang, WK; Lucanie, R; Reilly, R, 2002) |
| "We estimated the proportion of miscarriage to be almost doubled, whereas there was no increased risk of congenital abnormalities or prematurity in women exposed to a drug overdose compared with the background population." | 1.31 | Pregnancy outcome after suicide attempt by drug use: a Danish population-based study. ( Flint, C; Larsen, H; Nielsen, GL; Olsen, J; Sørensen, HT, 2002) |
| " Twenty-eight patients (39%) had severe liver toxic effects, and six of them underwent liver transplantation." | 1.30 | Outcome of acetaminophen overdose in pediatric patients and factors contributing to hepatotoxicity. ( Ament, ME; Berquist, W; Davis, J; Gugig, R; Heyman, MB; McDiarmid, S; Rivera-Penera, T; Rosenthal, P; Vargas, J, 1997) |
| "Adjustment disorder was the most common diagnosis followed by depression." | 1.30 | Overdose among youth in Bahrain: psycho-social characteristics, contact with helping agencies and problems. ( al-Ansari, AM; Buzaboon, B; Hamadeh, RR; Marhoon, H; Matar, AM; Raees, AG, 1997) |
| "Acetaminophen overdose was the most frequent cause (60 patients; 20%), followed by cryptogenic/non A non B non C (NANBNC; 15%), idiosyncratic drug reactions (12%), hepatitis B (10%), and hepatitis A (7%)." | 1.30 | Etiology and outcome for 295 patients with acute liver failure in the United States. ( Atillasoy, E; Caldwell, C; Crippin, JS; Flamm, S; Hay, JE; Kowdley, KV; Lee, WM; McCashland, TM; Rosen, H; Schiff, ER; Schiodt, FV; Shakil, AO; Somberg, KA; Stribling, R, 1999) |
| "Hypothyroidism was induced by methimazole, propylthiouracil, or surgical thyroidectomy and confirmed by elevated serum levels of TSH." | 1.30 | Hypothyroidism protects rat liver from acetaminophen hepatotoxicity. ( Aeed, H; Avni, Y; Bruck, R; Frenkel, D; Halpern, Z; Matas, Z; Oren, R; Papa, M; Shirin, H; Zaidel, L, 1999) |
| "Paracetamol overdose may cause hepatic encephalopathy (HE)." | 1.30 | Prediction of hepatic encephalopathy in paracetamol overdose: a prospective and validated study. ( Bondesen, S; Christensen, E; Schiødt, FV; Tygstrup, N, 1999) |
| "Thirteen patients developed fulminant hepatic failure, one of whom received a liver transplant; this patient died post-transplantation and was the only death in the series." | 1.30 | Paracetamol overdose in a liver transplantation centre: an 8-year experience. ( Angus, PW; Gow, PJ; Smallwood, RA, 1999) |
| "Acetaminophen serum levels were rather low compared to cases with ingestion of one single overdose." | 1.30 | Fulminant liver failure in a young child following repeated acetaminophen overdosing. ( Babel, B; Bauer, M; Giesen, H; Patzelt, D, 1999) |
| "Acetaminophen overdose is a common intoxication in daily practice the standard treatment is N-acetylcysteine (NAC) antidotal therapy for possible poisoning." | 1.30 | Hemodialysis as adjunctive therapy for severe acetaminophen poisoning: a case report. ( Deng, JF; Tsai, WJ; Wu, ML; Yang, CC, 1999) |
| "We report a case of arthrogryposis multiplex congenita secondary to fetal hypokinesia in a 41-week gestation infant following antenatal central nervous system injury." | 1.30 | Arthrogryposis multiplex congenita and bilateral mid-brain infarction following maternal overdose of co-proxamol. ( Battin, M; Counsell, SJ; Maalouf, EF; Manzur, AY; Rutherford, MA, 1997) |
| "Rats treated with misoprostol before and after APAP administration showed reduced OCT and ALT levels at 36 hr of overdose (454 +/- 446 IU/liter and 2571 +/- 2944 IU/liter, respectively) compared to those without misoprostol treatment (1348 +/- 480 IU/liter and 6077 +/- 3025 IU/liter, respectively, P < 0." | 1.29 | Misoprostol protection against acetaminophen-induced hepatotoxicity in the rat. ( Andrews, FJ; Lim, SP; O'Brien, PE, 1994) |
| "A pharmacokinetic program using population-based parameter estimates and a Bayesian forecasting model was retrospectively evaluated for predicting acetaminophen serum concentrations in overdose patients." | 1.29 | Prediction of acetaminophen concentrations in overdose patients using a Bayesian pharmacokinetic model. ( Gentry, CA; Paloucek, FP; Rodvold, KA, 1994) |
| " We conclude that chronic use of anticonvulsants enhances clinical features of paracetamol toxicity and discuss possible mechanisms by which this could be mediated." | 1.28 | Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure. ( Bray, GP; Harrison, PM; O'Grady, JG; Tredger, JM; Williams, R, 1992) |
| " Fifty-five patients (18%) had toxic paracetamol levels, 51% received treatment with NAC, including 40% of those with non-toxic levels, and 11% of those treated with NAC experienced side effects." | 1.28 | Hepatotoxicity from paracetamol self-poisoning in western Sydney: a continuing challenge. ( Batey, RG; Brotodihardjo, AE; Byth, K; Farrell, GC, 1992) |
| "She developed hepatic encephalopathy and it was then determined she had ingested APAP." | 1.28 | Orthotopic liver transplants necessitated by acetaminophen-induced hepatotoxicity. ( Dean, BS; Krenzelok, EP; Mrvos, R; Schneider, SM, 1992) |
| "To review the potential for anaphylactoid reactions to intravenously administered acetylcysteine when used in the treatment of acetaminophen overdose." | 1.28 | Anaphylactoid reaction to intravenous acetylcysteine associated with electrocardiographic abnormalities. ( Bonfiglio, MF; Hulisz, DT; Martin, BR; Traeger, SM, 1992) |
| "Acetaminophen is a popular nonprescription analgesic that is often taken in overdose by adolescents during suicidal gestures." | 1.28 | Acetaminophen overdose as a suicidal gesture: a survey of adolescents' knowledge of its potential for toxicity. ( Diaco, D; Harris, E; Moreno, A; Myers, WC; Otto, TA, 1992) |
| "Flumazenil is a competitive benzodiazepine antagonist." | 1.28 | Complete heart block after flumazenil. ( Clarke, F; Herd, B, 1991) |
| "A patient is described where oesophageal varices developed and bled 13 days after a paracetamol overdose." | 1.28 | Fatal variceal haemorrhage after paracetamol overdose. ( Losowsky, MS; Thornton, JR, 1989) |
| "Status epilepticus is a rare complication of ECT." | 1.28 | Status epilepticus after electroconvulsive therapy. ( Riddle, W; Scott, AI, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (0.50) | 18.7374 |
| 1990's | 234 (19.32) | 18.2507 |
| 2000's | 375 (30.97) | 29.6817 |
| 2010's | 470 (38.81) | 24.3611 |
| 2020's | 126 (10.40) | 2.80 |
| Authors | Studies |
|---|---|
| Yao, F | 1 |
| Wang, X | 2 |
| Cao, X | 1 |
| Zhang, K | 1 |
| Sun, J | 2 |
| Li, Y | 1 |
| Sui, J | 1 |
| Liu, Y | 1 |
| Roumeliotis, N | 1 |
| Frndova, H | 1 |
| Pullenayegum, E | 1 |
| Taddio, A | 1 |
| Rochon, P | 1 |
| Parshuram, CS | 1 |
| Lewis, JC | 1 |
| Lim, M | 1 |
| Lai, L | 1 |
| Mendoza, E | 1 |
| Albertson, TE | 2 |
| Chenoweth, JA | 2 |
| Zhou, Y | 2 |
| Wang, C | 4 |
| Kou, J | 1 |
| Wang, M | 1 |
| Rong, X | 1 |
| Pu, X | 1 |
| Xie, X | 1 |
| Han, G | 1 |
| Pang, X | 1 |
| Mehrpour, O | 4 |
| Saeedi, F | 1 |
| Hoyte, C | 3 |
| Link, SL | 1 |
| Rampon, G | 1 |
| Osmon, S | 1 |
| Scalzo, AJ | 1 |
| Rumack, BH | 17 |
| Gheshlaghi, F | 1 |
| Yarmohammadi, H | 1 |
| Gheshlaghi, S | 1 |
| Wong, A | 22 |
| Syafira, N | 1 |
| Graudins, A | 23 |
| Yarema, M | 6 |
| Huang, Y | 2 |
| Xie, Y | 7 |
| Yang, D | 1 |
| Xiong, M | 1 |
| Chen, X | 1 |
| Wu, D | 1 |
| Wang, Q | 3 |
| Chen, H | 4 |
| Zheng, L | 1 |
| Huang, K | 1 |
| Mudan, A | 1 |
| Lebin, JA | 1 |
| Wu, AHB | 1 |
| Livshits, Z | 1 |
| Thanacoody, HKR | 1 |
| Bateman, DN | 31 |
| Jasat, H | 1 |
| Thompson, J | 1 |
| Sonneborn, O | 1 |
| Dayment, J | 1 |
| Miller, C | 3 |
| Sriraj, P | 1 |
| Boonmars, T | 1 |
| Aukkanimart, R | 1 |
| Artchayasawat, A | 1 |
| Borlace, GN | 1 |
| Ratanasuwan, P | 1 |
| Pumhirunroj, B | 1 |
| Akakpo, JY | 7 |
| Ramachandran, A | 12 |
| Curry, SC | 11 |
| Jaeschke, H | 35 |
| Jeong, HH | 1 |
| Cha, K | 1 |
| Choi, KH | 1 |
| So, BH | 1 |
| Friedman, N | 1 |
| Kim, K | 1 |
| Lasoff, D | 1 |
| Balen, F | 1 |
| Senette, M | 1 |
| Nekkaz, M | 1 |
| De Riols, P | 1 |
| Jolly, L | 1 |
| Charpentier, S | 1 |
| Chomchai, S | 5 |
| Mekavuthikul, P | 1 |
| Phuditshinnapatra, J | 1 |
| Chomchai, C | 5 |
| Ghallab, A | 2 |
| Hassan, R | 1 |
| Hofmann, U | 1 |
| Friebel, A | 1 |
| Hobloss, Z | 1 |
| Brackhagen, L | 1 |
| Begher-Tibbe, B | 1 |
| Myllys, M | 1 |
| Reinders, J | 1 |
| Overbeck, N | 1 |
| Sezgin, S | 1 |
| Zühlke, S | 1 |
| Seddek, AL | 1 |
| Murad, W | 1 |
| Brecklinghaus, T | 1 |
| Kappenberg, F | 1 |
| Rahnenführer, J | 1 |
| González, D | 1 |
| Goldring, C | 1 |
| Copple, IM | 1 |
| Marchan, R | 1 |
| Longerich, T | 1 |
| Vucur, M | 1 |
| Luedde, T | 1 |
| Urban, S | 1 |
| Canbay, A | 1 |
| Schreiter, T | 1 |
| Trauner, M | 1 |
| Olyaee, M | 2 |
| Sowa, JP | 1 |
| Hoehme, S | 1 |
| Hengstler, JG | 2 |
| Duan, L | 3 |
| Sanchez-Guerrero, G | 1 |
| Antoniou, T | 1 |
| Guan, Q | 1 |
| Martins, D | 1 |
| Gomes, T | 1 |
| Sivilotti, MLA | 10 |
| Yarema, MC | 9 |
| Juurlink, DN | 5 |
| Boussetta-Charfi, O | 1 |
| D'Andon, CF | 1 |
| Nguyen, H | 2 |
| Launay, M | 1 |
| Sudanagunta, S | 1 |
| Camarena-Michel, A | 1 |
| Pennington, S | 1 |
| Leonard, J | 1 |
| Wang, GS | 3 |
| Isbister, GK | 18 |
| Polanski, R | 1 |
| Cooper, JM | 1 |
| Keegan, M | 1 |
| Isoardi, KZ | 3 |
| Ali, K | 1 |
| Chiang, W | 1 |
| Wang, JJ | 1 |
| Abbas, AA | 1 |
| Hamdy, A | 1 |
| Ahmed, AE | 1 |
| Long, A | 1 |
| Magrath, M | 1 |
| Mihalopoulos, M | 1 |
| Rule, JA | 1 |
| Agrawal, D | 1 |
| Haley, R | 1 |
| Kleinschmidt, K | 1 |
| Lee, WM | 16 |
| Humphries, C | 2 |
| Roberts, G | 2 |
| Taheem, A | 2 |
| Abdel Kader, H | 1 |
| Kidd, R | 2 |
| Smith, J | 2 |
| Love, JS | 1 |
| Karshenas, DL | 1 |
| Spyres, MB | 3 |
| Farrugia, LA | 1 |
| Kang, AM | 2 |
| Campleman, SL | 1 |
| Li, S | 1 |
| Wax, PM | 2 |
| Brent, J | 3 |
| Aldy, K | 1 |
| Monte, AA | 4 |
| Arriaga Mackenzie, I | 1 |
| Pattee, J | 1 |
| Kaiser, S | 1 |
| Willems, E | 1 |
| Rumack, B | 2 |
| Reynolds, KM | 5 |
| Dart, RC | 22 |
| Heard, KJ | 7 |
| Spyker, DA | 5 |
| Yip, L | 3 |
| Reynolds, K | 1 |
| Brittain, S | 1 |
| Gao, Y | 2 |
| Zhang, R | 1 |
| Liang, H | 1 |
| Motohashi, K | 1 |
| Thanacoody, RH | 1 |
| Kader, HA | 1 |
| Chiew, AL | 12 |
| Buckley, NA | 21 |
| Glicksberg, L | 1 |
| Dempsey, SK | 1 |
| Casey, BK | 1 |
| Lu, R | 1 |
| Yu, RJ | 1 |
| Yang, C | 1 |
| Xuan, Y | 1 |
| Wang, Z | 1 |
| He, Z | 1 |
| Xu, Y | 3 |
| Kou, L | 1 |
| Zhao, YZ | 1 |
| Yao, Q | 1 |
| Xu, SH | 1 |
| Janković, SM | 3 |
| Yau, CE | 3 |
| Lim, BP | 3 |
| Ng, M | 3 |
| Ponampalam, R | 3 |
| Lim, DYZ | 3 |
| Chin, YH | 3 |
| Ho, AFW | 3 |
| Dear, JW | 22 |
| Filip, AB | 2 |
| Mullins, ME | 8 |
| Rajaraman, N | 1 |
| Gray, L | 2 |
| Anderson, M | 1 |
| Kelgeri, C | 1 |
| Strehle, EM | 1 |
| Haar, I | 1 |
| Albert, K | 1 |
| Wilson, K | 2 |
| Hasara, S | 1 |
| Stathakis, P | 1 |
| Page, C | 1 |
| Ress, K | 1 |
| Chan, BSH | 4 |
| Cairns, R | 1 |
| Noghrehchi, F | 1 |
| Ferretti, S | 1 |
| Curatola, A | 1 |
| Chiaretti, A | 1 |
| Graglia, B | 1 |
| Gatto, A | 1 |
| Capossela, L | 1 |
| Pansini, V | 1 |
| Abushanab, D | 1 |
| Gasim, M | 1 |
| Devi, D | 1 |
| Elbdairy, M | 1 |
| Elqasass, H | 1 |
| Ahmed, N | 2 |
| Vincent, M | 1 |
| Abdul Rouf, PV | 1 |
| Mohammed, HR | 1 |
| Hail, MA | 1 |
| Thomas, B | 1 |
| Elkassem, W | 1 |
| Hanssens, Y | 1 |
| Elgassim, M | 1 |
| Elmoheen, A | 1 |
| Azad, A | 1 |
| Mohammed, S | 2 |
| Salem, W | 1 |
| Rianprakaisang, T | 1 |
| Blumenberg, A | 1 |
| Hendrickson, RG | 2 |
| Warrillow, S | 1 |
| Tibballs, H | 1 |
| Bailey, M | 1 |
| McArthur, C | 1 |
| Lawson-Smith, P | 1 |
| Prasad, B | 1 |
| Anstey, M | 1 |
| Venkatesh, B | 1 |
| Dashwood, G | 1 |
| Walsham, J | 1 |
| Holt, A | 2 |
| Wiersema, U | 1 |
| Gattas, D | 1 |
| Zoeller, M | 1 |
| Garcia Alvarez, M | 1 |
| Bellomo, R | 1 |
| Al Humayed, S | 1 |
| Al-Hashem, F | 1 |
| Haidara, MA | 1 |
| El Karib, AO | 1 |
| Kamar, SS | 1 |
| Amin, SN | 1 |
| Al-Ani, B | 1 |
| Vazquez, JH | 1 |
| Clemens, MM | 2 |
| Allard, FD | 1 |
| Yee, EU | 1 |
| Kennon-McGill, S | 3 |
| Mackintosh, SG | 1 |
| Hambuchen, MD | 1 |
| McGill, MR | 16 |
| Jackson, A | 1 |
| Little, M | 2 |
| Nordmark Grass, J | 2 |
| Lindeman, E | 1 |
| Höjer, J | 2 |
| Personne, M | 2 |
| KhabazianZadeh, F | 1 |
| Kazemi, T | 1 |
| Nakhaee, S | 1 |
| Ng, PC | 2 |
| James, LP | 14 |
| Pickering, JW | 1 |
| McArdle, K | 1 |
| Shah, KR | 3 |
| Beuhler, MC | 5 |
| Woolum, JA | 1 |
| Hays, WB | 1 |
| Patel, KH | 1 |
| Reith, D | 3 |
| Pomerleau, A | 1 |
| Soderstrom, J | 1 |
| Woolbright, BL | 2 |
| Zhang, Y | 2 |
| Dong, V | 1 |
| Nanchal, R | 1 |
| Karvellas, CJ | 2 |
| Mutsaers, A | 2 |
| Green, JP | 2 |
| Johnson, DW | 7 |
| Huang, YQ | 1 |
| Tremblay, JA | 1 |
| Chapdelaine, H | 1 |
| Luong, ML | 1 |
| Carrier, FM | 1 |
| Saragiotto, BT | 1 |
| Abdel Shaheed, C | 1 |
| Maher, CG | 1 |
| Heard, K | 11 |
| Dart, R | 2 |
| Ahn, JH | 1 |
| Cho, YS | 1 |
| Cho, GC | 1 |
| Krauskopf, J | 3 |
| Gosink, MM | 1 |
| Schomaker, S | 1 |
| Caiment, F | 3 |
| Warner, R | 1 |
| Johnson, K | 1 |
| Kleinjans, J | 1 |
| Aubrecht, J | 3 |
| Hu, J | 1 |
| Lemasters, JJ | 2 |
| Yasri, S | 1 |
| Wiwanitkit, V | 1 |
| Haidar, MK | 1 |
| Vogt, F | 1 |
| Takahashi, K | 1 |
| Henaff, F | 1 |
| Umphrey, L | 1 |
| Morton, N | 1 |
| Bawo, L | 1 |
| Kerkula, J | 1 |
| Ferner, R | 1 |
| Porten, K | 1 |
| Baud, FJ | 1 |
| Piel, S | 1 |
| Chamkha, I | 1 |
| Dehlin, AK | 1 |
| Ehinger, JK | 1 |
| Sjövall, F | 1 |
| Elmér, E | 1 |
| Hansson, MJ | 1 |
| Laurent, D | 1 |
| Semple, F | 1 |
| Starkey Lewis, PJ | 1 |
| Rose, E | 1 |
| Black, HA | 1 |
| Coe, J | 1 |
| Forbes, SJ | 1 |
| Arends, MJ | 1 |
| Aitman, TJ | 1 |
| Crow, EM | 1 |
| Boley, SP | 1 |
| Levine, M | 3 |
| Stellpflug, SJ | 1 |
| Gao, Z | 1 |
| Zhang, J | 1 |
| Wei, L | 1 |
| Yang, X | 3 |
| Cheng, B | 1 |
| Yang, Z | 1 |
| Gao, W | 1 |
| Song, C | 1 |
| Miao, W | 1 |
| Williams, K | 1 |
| Liu, C | 1 |
| Xu, Q | 1 |
| Chang, Y | 1 |
| Fox, C | 2 |
| Geib, AJ | 3 |
| Murphy, C | 2 |
| Kopec, K | 2 |
| Kerns Ii, W | 1 |
| Dulaney, A | 2 |
| Hayden, JC | 1 |
| Kelly, L | 1 |
| McNicholas, F | 1 |
| Eddleston, M | 5 |
| Vale, JA | 5 |
| Chiew, A | 2 |
| Yeager, LH | 1 |
| Freeman, WE | 1 |
| Epperson, LC | 1 |
| Weiss, ST | 1 |
| Cao, DJ | 1 |
| Kerns, W | 1 |
| Hall, B | 1 |
| Blind, F | 1 |
| Casey, D | 3 |
| Geulayov, G | 2 |
| Bale, E | 2 |
| Brand, F | 1 |
| Clements, C | 2 |
| Kapur, N | 10 |
| Ness, J | 2 |
| Patel, A | 1 |
| Waters, K | 3 |
| Hawton, K | 22 |
| Kimergård, A | 1 |
| Parkin, S | 1 |
| Jennings, S | 1 |
| Brobbin, E | 1 |
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| Arshad, MA | 1 |
| Murphy, N | 2 |
| Bangash, MN | 1 |
| Normandin, PA | 1 |
| Benotti, SA | 1 |
| Mullins, MA | 1 |
| Zhou, Z | 1 |
| Qi, J | 1 |
| Zhao, J | 1 |
| Seo, JH | 1 |
| Shin, DG | 1 |
| Cha, JD | 1 |
| Lim, CW | 1 |
| Kim, JW | 1 |
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| Chabert, A | 1 |
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| Gitton, A | 1 |
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| Oudart, JB | 1 |
| Rouphael, C | 1 |
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| Martinez-De la Torre, A | 1 |
| Weiler, S | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacogenomics of APAP Induced DILI in Chinese Population.[NCT04964310] | 339 participants (Anticipated) | Observational | 2020-08-31 | Recruiting | |||
| A Randomised Open Label Exploratory, Safety and Tolerability Study With PP100-01 in Patients Treated With the 12-hour Regimen of N-Acetylcysteine for Paracetamol/Acetaminophen Overdose (The POP Trial)[NCT03177395] | Phase 1 | 24 participants (Actual) | Interventional | 2017-06-08 | Completed | ||
| Study of Metformin Overdose in Adult Patients Treated at the University Hospital of Nancy: Single-center Descriptive Retrospective Observational Study[NCT04762966] | 50 participants (Anticipated) | Observational | 2021-03-01 | Recruiting | |||
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| Use of Intravenous Acetaminophen in Adolescents and Pediatrics Undergoing Spinal Fusion Surgery: Randomized Controlled Trial[NCT04959591] | Phase 3 | 99 participants (Actual) | Interventional | 2021-06-01 | Completed | ||
| Randomized Placebo Controlled Trial of Intravenous N-Acetylcysteine for the Treatment of Acute Ischemic Stroke[NCT04918719] | Phase 2 | 118 participants (Anticipated) | Interventional | 2021-06-01 | Not yet recruiting | ||
| Evaluation of MicroRNA Expression in Blood and Cytology Specimens as a Novel Method for Detecting Barrett's Esophagus[NCT02464930] | 220 participants (Anticipated) | Observational | 2015-04-30 | Recruiting | |||
| A Feasibility Study of Circulating microRNAs as Disease Markers in Pediatric Cancers[NCT01541800] | 20 participants (Anticipated) | Observational | 2010-03-31 | Recruiting | |||
| A 3-part, Phase 1a/1b, First-in-human, Randomized, Double-blind, Placebo-controlled Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Oral CDX-7108 in Healthy Adult Subjects and to Evaluate Proof-of-con[NCT05082051] | Phase 1 | 54 participants (Actual) | Interventional | 2021-10-11 | Completed | ||
| An Open Label Extension of XPro1595 in Patients With Alzheimer's Disease That Have Completed a Phase 1 or Phase 2 Study With XPro1595[NCT05522387] | Phase 2 | 261 participants (Anticipated) | Interventional | 2023-02-21 | Recruiting | ||
| An Open-label, Randomised, Cross-over, Single Centre Study in Healthy Volunteers to Optimise the Rotacap Formulation andROTAHALER Device for Delivery of Fluticasone Propionate/Salmeterol.[NCT01540708] | Phase 1 | 36 participants (Actual) | Interventional | 2012-01-16 | Completed | ||
| Treatment of Acetaminophen Toxicity With Intravenous vs. Oral N-acetylcysteine: A Retrospective Review[NCT01465542] | 47 participants (Actual) | Observational | 2011-06-30 | Completed | |||
| Divided Drug Delivery : a Way to Prevent Repeated Volutary Drug Intoxications.[NCT02869724] | 30 participants (Anticipated) | Interventional | 2014-03-31 | Recruiting | |||
| Evaluating the Effects of Acupuncture in the Treatment of Taxane Induces Peripheral Neuropathy (TIPN)[NCT02831114] | 18 participants (Actual) | Interventional | 2016-05-31 | Completed | |||
| Consumer Understanding and Use of Non-Prescription Analgesics, Investigation of Efficacy of Improved Acetaminophen Labeling[NCT01592448] | 662 participants (Actual) | Observational | 2012-10-31 | Completed | |||
| N-Acetylcysteine to Prevent Radiocontrast Nephropathy in Emergency Department Patients[NCT00780962] | Phase 2 | 399 participants (Actual) | Interventional | 2007-10-16 | Completed | ||
| Measurement of Nitrotyrosine Adducts and Cytokines in Acetaminophen Overdose Patients[NCT00166608] | 111 participants (Actual) | Observational | 2002-12-31 | Completed | |||
| A Phase 2a Study to Evaluate the Safety and Tolerability of OCR-002 (Ornithine Phenylacetate) in the Treatment of Patients With Acute Liver Failure/Severe Acute Liver Injury[NCT01548690] | Phase 2 | 47 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| Treatment of Acetaminophen Toxicity With Intravenous vs Oral N-acetylcysteine: A Retrospective Review[NCT00725179] | 130 participants (Anticipated) | Observational | 2008-08-31 | Completed | |||
| Pilot Study of a Smart Phone Assisted Problem Solving Therapy for Men Who Have Presented With Intentional Self-harm to Emergency Departments[NCT02718248] | 7 participants (Actual) | Interventional | 2016-09-30 | Completed | |||
| The BEACON Study: Protocol for Cluster RCT of a Service to Deliver Smartphone-Assisted Problem-Solving Therapy Compared to Usual Care in Men Who Present With Intentional Self-Harm to the ED in Ontario (Protocol A)[NCT03489382] | 0 participants (Actual) | Interventional | 2020-03-31 | Withdrawn (stopped due to Change in protocol design due to COVID-19 pandemic) | |||
| The BEACON Study: Protocol for a Pilot Randomized Controlled Trial of Smartphone-assisted Problem Solving Therapy in Men Who Present With Intentional Self-harm to Emergency Departments in Ontario[NCT03473535] | 100 participants (Anticipated) | Interventional | 2020-03-31 | Active, not recruiting | |||
| A Double-blind Placebo-controlled Evaluation of Ropivacaine Efficacy by Local Per and Post Hepatectomy Infiltrations for Adult Pain Management[NCT01194843] | 85 participants (Actual) | Interventional | 2009-03-31 | Completed | |||
| Acetaminophen in Combination With N-Acetylcysteine (NAC) vs. Placebo in the Treatment of Fever: A Double-Blind, Randomized Control Study[NCT01137591] | 0 participants (Actual) | Interventional | 2009-04-30 | Withdrawn (stopped due to Unable to recruit sufficient participants due to lack of funding; PI has left the institution.) | |||
| An Open-label, Single-dose, Pharmacokinetic Study of Acetaminophen/Naproxen Sodium Fixed Combination Tablets in Adolescents 12 to <17 Years of Age With Orthodontic Pain[NCT05844995] | Phase 1 | 30 participants (Anticipated) | Interventional | 2023-09-13 | Recruiting | ||
| Collection of Blood and Stool Samples in Patients With Acute Hepatitis[NCT00001879] | 200 participants | Observational | 1999-03-31 | Completed | |||
| Attenuation of Myocardial Dysfunction by N-Acetylcysteine in Infants Undergoing Arterial Switch Procedure[NCT00374088] | Phase 2 | 21 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| Randomized Double-blind Controlled Study to Assess the Efficacy of Intravenous Acetaminophen Associated With Strong Opioids in the Management of Acute Pain in Adult Cancer Patients[NCT04779567] | Phase 4 | 112 participants (Actual) | Interventional | 2019-06-10 | Completed | ||
| Comparison of Supportive Therapies for Symptom Relief From Pediatric Upper Respiratory Infections (URIs)[NCT01814293] | 0 participants (Actual) | Interventional | 2013-05-31 | Withdrawn (stopped due to loss of funding. No data was collected.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The alanine aminotransferase (ALT) test is a blood test that checks for liver damage. (NCT03177395)
Timeframe: 10 hours
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 41.4 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 22.9 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 25.3 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 15.0 |
The alanine aminotransferase (ALT) test is a blood test that checks for liver damage. (NCT03177395)
Timeframe: 20 hours
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 43.3 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 20.4 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 25.4 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 16.4 |
The alanine aminotransferase (ALT) test is a blood test that checks for liver damage. (NCT03177395)
Timeframe: Baseline
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 42.5 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 24.6 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 29.4 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 17.7 |
Caspace-cleaved Keratin-18 (NCT03177395)
Timeframe: Ratio - value at 20 hours divided by baseline value for each patient
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 2.22 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 1.49 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 1.02 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 1.08 |
The shorter, Caspase cleaved form of K-18 is released following hepatocyte apoptosis (programmed cell death). (NCT03177395)
Timeframe: 10 hours
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 72 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 53 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 56 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 78 |
The shorter, Caspase cleaved form of K-18 is released following hepatocyte apoptosis (programmed cell death). (NCT03177395)
Timeframe: 20 hours
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 149 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 66 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 85 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 111 |
The shorter, Caspase cleaved form of K-18 is released following hepatocyte apoptosis (programmed cell death). (NCT03177395)
Timeframe: Baseline (2 hours)
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 67 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 45 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 84 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 104 |
international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF) (NCT03177395)
Timeframe: 10 hours
| Intervention | ratio (Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 1.30 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 1.17 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 1.20 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 1.22 |
international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF) (NCT03177395)
Timeframe: 20 hours
| Intervention | ratio (Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 1.18 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 1.07 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 1.08 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 1.22 |
international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF) (NCT03177395)
Timeframe: Baseline
| Intervention | ratio (Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 1.02 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 1.00 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 0.98 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 1.05 |
international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF) (NCT03177395)
Timeframe: value at 20 hours divided by baseline value for each patient
| Intervention | ratio (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 1.15 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 1.07 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 1.10 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 1.10 |
In paracetamol overdose, the full-length variant of Keratin-18 (K-18) is released by necrotic hepatocyte death. (NCT03177395)
Timeframe: 20 hours
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 347 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 229 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 172 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 181 |
In paracetamol overdose, the full-length variant of Keratin-18 (K-18) is released by necrotic hepatocyte death. (NCT03177395)
Timeframe: Baseline (2 hours)
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 187 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 177 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 193 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 128 |
In paracetamol overdose, the full-length variant of Keratin-18 (K-18) is released by necrotic hepatocyte death. (NCT03177395)
Timeframe: Ratio - value at 20 hours divided by baseline value for each patient
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 1.85 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 1.29 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 0.89 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 1.41 |
In paracetamol overdose, the full-length variant of Keratin-18 (K-18) is released by necrotic hepatocyte death. (NCT03177395)
Timeframe: 10 hours
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 182 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 152 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 170 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 111 |
MiR-122 is a biomarker specific for liver injury and fully conserved (translational) across in vitro models, in vivo models and humans. MiR-122 is an early marker for acute liver injury which predicts a rise in ALT activity following paracetamol overdose (NCT03177395)
Timeframe: 20 hours
| Intervention | copies/mcL (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 216,256 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 57,664 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 202,271 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 40,745 |
MiR-122 is a biomarker specific for liver injury and fully conserved (translational) across in vitro models, in vivo models and humans. MiR-122 is an early marker for acute liver injury which predicts a rise in ALT activity following paracetamol overdose (NCT03177395)
Timeframe: Baseline (2 h)
| Intervention | copies/mcL (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 146,363 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 116,749 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 194,075 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 36,051 |
MiR-122 is a biomarker specific for liver injury and fully conserved (translational) across in vitro models, in vivo models and humans. MiR-122 is an early marker for acute liver injury which predicts a rise in ALT activity following paracetamol overdose (NCT03177395)
Timeframe: Ratio - value at 20 hours divided by baseline value for each patient
| Intervention | copies/mcL (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 1.48 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 0.49 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 1.04 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 1.13 |
MiR-122 is a biomarker specific for liver injury and fully conserved (translational) across in vitro models, in vivo models and humans. MiR-122 is an early marker for acute liver injury which predicts a rise in ALT activity following paracetamol overdose (NCT03177395)
Timeframe: 10 hours
| Intervention | DCt (Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 5.41 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 6.14 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 5.01 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 9.00 |
MiR-122 is a biomarker specific for liver injury and fully conserved (translational) across in vitro models, in vivo models and humans. MiR-122 is an early marker for acute liver injury which predicts a rise in ALT activity following paracetamol overdose (NCT03177395)
Timeframe: 20 hours
| Intervention | DCt (Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 4.85 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 7.12 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 4.49 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 8.44 |
MiR-122 is a biomarker specific for liver injury and fully conserved (translational) across in vitro models, in vivo models and humans. MiR-122 is an early marker for acute liver injury which predicts a rise in ALT activity following paracetamol overdose (NCT03177395)
Timeframe: Baseline (2 hours)
| Intervention | DCt (Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 5.58 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 5.85 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 4.43 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 8.73 |
MiR-122 is a biomarker specific for liver injury and fully conserved (translational) across in vitro models, in vivo models and humans. MiR-122 is an early marker for acute liver injury which predicts a rise in ALT activity following paracetamol overdose (NCT03177395)
Timeframe: 10 hours
| Intervention | copies/mcL (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 206,205 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 109,882 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 196,732 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 37,066 |
participants required additional NAC infusions after the 12-hour NAC regimen (NCT03177395)
Timeframe: Additional NAC at 12 hour
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| None | One | Two | |
| Acetylcysteine (N-acetylcysteine; NAC) | 3 | 1 | 2 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 5 | 1 | 0 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 6 | 0 | 0 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 6 | 0 | 0 |
Adverse Events and Serious Adverse Events (NCT03177395)
Timeframe: 90 days
| Intervention | participants (Number) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Any Adverse event | Any serious adverse event | Adverse event after commencement of NAC treatment | Serious AE after commencement of NAC treatment | Adverse event where outcome was death | Adverse event unrelated to NAC | Adverse event possibly related to NAC | Adverse event probably related to NAC | Adverse event definitely related to NAC | Adverse event unrelated to PP100-01 | Adverse event possibly related to PP100-01 | Adverse event probably related to PP100-01 | Adverse event definitely related to PP100-01 | Any suspected unexpected serious adverse reaction | SUSAR to NAC | SUSAR to PP100-01 | SUSAR to NAC and PP100-01 | |
| Acetylcysteine (N-acetylcysteine; NAC) | 6 | 2 | 6 | 1 | 0 | 3 | 2 | 3 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 6 | 4 | 5 | 1 | 0 | 5 | 2 | 2 | 3 | 6 | 4 | 0 | 0 | 0 | 0 | 0 | 0 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 6 | 2 | 6 | 1 | 1 | 3 | 2 | 3 | 1 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 6 | 3 | 6 | 2 | 0 | 5 | 2 | 2 | 1 | 6 | 2 | 0 | 0 | 1 | 0 | 1 | 0 |
Contrast-induced nephropathy was defined as an increase in serum creatinine level of greater than or equal to 0.5 mg/dL or an increase of 25% above baseline. The primary outcome was measured by the change in serum creatinine level from the pre-radiocontrast baseline to the serum creatinine level measured 48 to 72 hours after radiocontrast administration. (NCT00780962)
Timeframe: 48-72 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| N-Acetycysteine Group | 14 |
| 0.9% Sodium-chloride Group | 12 |
To evaluate the effect of OCR-002 on ammonia levels in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: Baseline and 72 Hours
| Intervention | Percent Change (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 41.2 |
| Maximum Dose Level 6.65 g/24h | 16.6 |
| Maximum Dose Level 10 g/24h | 41.8 |
| Maximum Dose Level 20g/24h | 38.4 |
To evaluate the steady state pharmacokinetic and pharmacodynamic profile of OCR-002 in patients with impaired and intact renal function using urinary phenylacetylglutamine (PAGN) as a surrogate marker (NCT01548690)
Timeframe: 24 Hours after last infusion
| Intervention | micrograms per millileter (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 65.6 |
| Maximum Dose Level 6.65 g/24h | 32.2 |
| Maximum Dose Level 10 g/24h | 33.4 |
| Maximum Dose Level 20g/24h | 104.9 |
The orientation log focuses on orientation to place, time, and circumstance. There are 10 items on the orientation log, which are scored 0-3. A spontaneous correct response is awarded 3 points. A spontaneous response that is lacking or incorrect, but a correct response is provided following a logical cue is awarded 2 points. A score of 1 is given if spontaneous and cued responses are lacking or incorrect, but a correct response is provided in a recognition format. A score of 0 is given if the spontaneous, cued, or recognition format does not generate a correct answer. Scores from the 10 items are summed and the final score ranges from 0 to 30. (NCT01548690)
Timeframe: 30 Days
| Intervention | units on a scale (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 23.8 |
| Maximum Dose Level 6.65 g/24h | 24.0 |
| Maximum Dose Level 10 g/24h | 24.0 |
| Maximum Dose Level 20g/24h | 24.0 |
The West Haven Criteria (WHC) for Hepatic Encephalopathy measures the severity of encephalopathy and patient's level of consciousness. The scale ranges from 0 to 4; a minimum score of 0 represents a better outcome, and a maximum total score of 4 represents a worse outcome. A score of 0 corresponds to normal consciousness and behavior and normal neurological examination. A score of 1 corresponds to mild lack of awareness, shortened attention span, and impaired addition or subtraction; mild asterixis or tremor. A score of 2 corresponds to lethargy, disorientated or inappropriate behavior, obvious asterixis; slurred speech. A score of 3 corresponds to somnolent but arousable, gross disorientation or bizarre behavior, muscle rigidity and clonus; hyperreflexia. A score of 4 corresponds to coma and decerebrate posturing. (NCT01548690)
Timeframe: 120 hours from start of infusion
| Intervention | units on a scale (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 2.4 |
| Maximum Dose Level 6.65 g/24h | 3.2 |
| Maximum Dose Level 10 g/24h | 1.6 |
| Maximum Dose Level 20g/24h | 1.8 |
To evaluate the safety and tolerability of OCR-002 in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: 30 Days
| Intervention | Participants (Count of Participants) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 0 |
| Maximum Dose Level 6.65 g/24h | 0 |
| Maximum Dose Level 10 g/24h | 0 |
| Maximum Dose Level 20g/24h | 0 |
Will be used to assess the feasibility of recruitment for a larger, multicentre cluster randomized controlled trial (RCT). To test feasibility in patients the investigators aim to recruit at least half of the men the study team ask to take part in the pilot study. To test feasibility in referring clinicians, the aim is that at least half of men who present with intentional self-harm to the psychiatric emergency service will be approached and complete the The Ottawa Hospital (TOH) form allowing contact details to be passed on to researchers. (NCT02718248)
Timeframe: Within 6 months of study launch
| Intervention | percentage of participants enrolled (Number) |
|---|---|
| CHESS Mobile Health Group | 46.6 |
Bodily Pain was measured using the Bodily Pain subscale of the Medical Outcomes Survey Short Form 12 (SF-12). The SF-12 is a 12-item self-report survey that assesses general health and well-being using a total of 8 subscales. The Bodily Pain Subscale is scored using a range of 0-100, with a higher score indicating lower levels of bodily pain. (NCT02718248)
Timeframe: Baseline, Week 5
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | Week 5 | |
| CHESS Mobile Health Group | 71.43 | 82.14 |
"Measures change in the severity of depressive symptoms. Total scores on this scale range from 0 to 27, with higher scores indicating more severe depression symptoms. The scores on the Patient Health Questionnaire (PHQ-9) scale should be interpreted as follows:~0-4: Minimal Depression; 5-9: Mild Depression 10-14: Moderate Depression; 15-19: Moderately Severe Depression; 20 and Above: Severe Depression." (NCT02718248)
Timeframe: Baseline, Week 1, Week 2, Week 3, Week 4, Week 5
| Intervention | units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | |
| CHESS Mobile Health Group | 19.8 | 15.17 | 16.86 | 16.83 | 13.71 |
Emotional Role Limitations was measured using the Emotional Role Limitations subscale of the Medical Outcomes Survey Short Form 12 (SF-12). The SF-12 is a 12-item self-report survey that assesses general health and well-being using a total of 8 subscales. The Emotional Role Limitations Subscale is scored using a range of 0-100, with a higher score indicating fewer role limitations due to emotional health difficulties. (NCT02718248)
Timeframe: Baseline, Week 5
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | Week 5 | |
| CHESS Mobile Health Group | 26.79 | 44.64 |
General Health was measured using the General Health subscale of the Medical Outcomes Survey Short Form 12 (SF-12). The SF-12 is a 12-item self-report survey that assesses general health and well-being using a total of 8 subscales. The General Health Subscale is scored using a range of 0-100, with a higher score indicating higher levels of general health. (NCT02718248)
Timeframe: Baseline, Week 5
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | Week 5 | |
| CHESS Mobile Health Group | 42.14 | 48.57 |
Generic health-related quality of life index. The total scores on this measure range from 11111 to 33333, with lower values indicating higher levels of health-related quality of life. (NCT02718248)
Timeframe: Baseline and Week 5
| Intervention | units on a scale (Median) | |
|---|---|---|
| Baseline | Week 5 | |
| CHESS Mobile Health Group | 11223 | 11313 |
Mental Health Functioning was measured using the Mental Health subscale of the Medical Outcomes Survey Short Form 12 (SF-12). The SF-12 is a 12-item self-report survey that assesses general health and well-being using a total of 8 subscales. The Mental Health Functioning Subscale is scored using a range of 0-100, with a higher score indicating better mental health functioning. (NCT02718248)
Timeframe: Baseline, Week 5
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | Week 5 | |
| CHESS Mobile Health Group | 17.86 | 30.36 |
The investigators will ask participants about the user comprehension, user practicality and the methods of data collection with regards to the CHESS Mobile Health smart phone application. The Participant Exit Questionnaire will also ask that users make comments or suggestions for future use and development of the application. This will test the acceptability of the intervention and the acceptability of using routine data sources as outcome measures. (NCT02718248)
Timeframe: within 4 months of study completion
| Intervention | percentage of participants who agreed (Number) | ||||||
|---|---|---|---|---|---|---|---|
| Application Easy to Install | Application is User Friendly | Application was easy to use | PST is a good fit for me | In PST we worked on what I wanted | Application was useful | I would use the application again | |
| CHESS Mobile Health Group | 100.0 | 85.7 | 71.4 | 71.4 | 85.7 | 28.6 | 42.9 |
Participants were asked to use the EuroQol 5 Dimensions Visual Analytic Scale to assess their overall health on a scale from 0 to 100, with 100 being the best possible health state. (NCT02718248)
Timeframe: Baseline, Week 5
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | Week 5 | |
| CHESS Mobile Health Group | 47.57 | 60.29 |
Physical Functioning was measured using the Physical Functioning subscale of the Medical Outcomes Survey Short Form 12 (SF-12). The SF-12 is a 12-item self-report survey that assesses general health and well-being using a total of 8 subscales. The Physical Functioning Subscale is scored using a range of 0-100, with a higher score indicating better physical functioning. (NCT02718248)
Timeframe: Baseline and Week 5
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | Week 5 | |
| CHESS Mobile Health Group | 82.14 | 92.86 |
Physical Role Limitations was measured using the Physical Role Limitations subscale of the Medical Outcomes Survey Short Form 12 (SF-12). The SF-12 is a 12-item self-report survey that assesses general health and well-being using a total of 8 subscales. The Physical Role Limitations Subscale is scored using a range of 0-100, with a higher score indicating fewer role limitations due to physical health difficulties. (NCT02718248)
Timeframe: Baseline, Week 5
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | Week 5 | |
| CHESS Mobile Health Group | 75.0 | 83.93 |
Social Functioning was measured using the Social Functioning subscale of the Medical Outcomes Survey Short Form 12 (SF-12). The SF-12 is a 12-item self-report survey that assesses general health and well-being using a total of 8 subscales. The Social Functioning Subscale is scored using a range of 0-100, with a higher score indicating higher social functioning. (NCT02718248)
Timeframe: Baseline, Week 5
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | Week 5 | |
| CHESS Mobile Health Group | 28.57 | 35.71 |
Vitality was measured using the Vitality subscale of the Medical Outcomes Survey Short Form 12 (SF-12). The SF-12 is a 12-item self-report survey that assesses general health and well-being using a total of 8 subscales. The Vitality subscale is scored using a range of 0-100, with a higher score indicating a higher degree of vitality. (NCT02718248)
Timeframe: Baseline, Week 5
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | Week 5 | |
| CHESS Mobile Health Group | 25.00 | 46.43 |
Maximum serum creatinine over first 3 days postoperative. (NCT00374088)
Timeframe: 72 hours
| Intervention | mg/dL (Mean) |
|---|---|
| Placebo | 0.99 |
| N-acetylcysteine | 0.74 |
Serial cardiac output was measured by thermodilution. The outcome of maximum decline in indexed cardiac output from 1 hour postoperative to lowest output within 24 hours postoperative was then calculated and compared between NAC and placebo groups. (NCT00374088)
Timeframe: 24 hours
| Intervention | L/min/m2 (Mean) |
|---|---|
| Placebo | 0.68 |
| N-acetylcysteine | 0.29 |
Total urine output over the first 24 hours postoperative (NCT00374088)
Timeframe: 24 hours
| Intervention | mL (Mean) |
|---|---|
| Placebo | 96 |
| N-acetylcysteine | 176 |
140 reviews available for acetaminophen and Drug Overdose
| Article | Year |
|---|---|
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induc | 2022 |
On the Analytic Characteristics of Commercial Acetaminophen Assays in the United States.
Topics: Acetaminophen; Drug Overdose; Humans; United States | 2022 |
Hepatic failure with fatal outcome during pregnancy following administration of a single therapeutic dose of acetominophen: Case report and literature review.
Topics: Acetaminophen; Antipyretics; Drug Overdose; Fatal Outcome; Female; Humans; Liver Diseases; Liver Fai | 2022 |
Toxicology in the emergency department: what's new?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Australia; Drug Overdose; Drug-R | 2022 |
Performance of the paracetamol-aminotransferase multiplication product in risk stratification after paracetamol (acetaminophen) poisoning: a systematic review and meta-analysis.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2023 |
Performance of the paracetamol-aminotransferase multiplication product in risk stratification after paracetamol (acetaminophen) poisoning: a systematic review and meta-analysis.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2023 |
Performance of the paracetamol-aminotransferase multiplication product in risk stratification after paracetamol (acetaminophen) poisoning: a systematic review and meta-analysis.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2023 |
Performance of the paracetamol-aminotransferase multiplication product in risk stratification after paracetamol (acetaminophen) poisoning: a systematic review and meta-analysis.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2023 |
Acetaminophen poisoning-induced heart injury: a case-based review.
Topics: Acetaminophen; Drug Overdose; Female; Heart Injuries; Humans; Male | 2019 |
Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Analgesics, Non-Narcotic; Antidotes; Aus | 2020 |
Pathophysiology of Acute Liver Failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema | 2020 |
Pulmonary mucormycosis in a patient with acute liver failure: A case report and systematic review of the literature.
Topics: Acetaminophen; Antifungal Agents; Brain; Drug Overdose; Female; Humans; Immunocompromised Host; Live | 2020 |
A mitochondrial journey through acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver; MAP Ki | 2020 |
A clinician's guide to self-poisoning with paracetamol in youth: The what, when and why?
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Child; Drug Overdose; Drug-Rela | 2020 |
Metabolic and mitochondrial treatments for severe paracetamol poisoning: a systematic review.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Animals; Antidotes; Cimetidine; Drug Overdose; Edetic Acid; | 2020 |
Novel strategies for the treatment of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Over | 2020 |
Paracetamol self-poisoning: Epidemiological study of trends and patient characteristics from the multicentre study of self-harm in England.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; England; Epidemiologic Studies; Europe; Fema | 2020 |
Hidden Danger: Pediatric Acetaminophen Overdose Unintentional and Intentional Emergencies.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Drug Overdose; Emergency Nursing; Emerge | 2020 |
Paracetamol overdose in the newborn and infant: a life-threatening event.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Indu | 2021 |
[Research progress on hepatotoxicity of acetaminophen].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 2021 |
Acetaminophen Poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2021 |
A review of alternative intravenous acetylcysteine regimens for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Analgesics, Non-Narcotic; Antidotes; Che | 2021 |
Acetaminophen (APAP) hepatotoxicity-Isn't it time for APAP to go away?
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Failure, Acute; | 2017 |
Paracetamol: overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Antipyretics; Dose-Response Relation | 2017 |
[Treatment of paracetamol intoxication: taking into consideration dosage, route of administration, and risk factors].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Liver; Risk Assessment; Risk Factors | 2017 |
Interventions for paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Cysteamine; Dimercapro | 2018 |
BET 1: In paracetamol overdose, is oral N-acetylcysteine as effective as intravenous N-acetylcysteine?
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Administration, Oral; Adolescent; Drug O | 2018 |
Refractory Hypotension Caused by Prazosin Overdose Combined With Acetaminophen and Naproxen Toxicity: A Case Report and Review of the Literature.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antihy | 2018 |
Re-Examining Safety Protocols for Tylenol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 2017 |
Acute Liver Failure.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Critical Care; Drug Overdose; Hepatitis, Auto | 2018 |
Liver Regeneration after Acetaminophen Hepatotoxicity: Mechanisms and Therapeutic Opportunities.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 2019 |
What is the most appropriate dose of
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dos | 2019 |
Acetaminophen hepatotoxicity: A mitochondrial perspective.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatocytes; Humans; | 2019 |
Intravenous acetylcysteine for indications other than acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Animals; Antidotes; Drug Overdose; Hepat | 2013 |
Dipyridamole and paracetamol overdose resulting in multi-organ failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Depression; Dipyridamole; Drug Overdose; Female; Hospitaliz | 2013 |
Intentional overdose of azathioprine in a patient with systemic lupus erythematosus.
Topics: Acetaminophen; Adolescent; Affective Disorders, Psychotic; Anti-Inflammatory Agents, Non-Steroidal; | 2013 |
Paracetamol: a focus for the general pediatrician.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Drug Overdose; Fever; Humans; Pain; Risk Factors | 2014 |
Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Biomarkers; Chemical an | 2014 |
A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; | 2014 |
Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients.
Topics: Acetaminophen; Animals; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Model | 2014 |
New problems arising from old drugs: second-generation effects of acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Asthma; Chemical and Drug Induced Liver Injury; Ch | 2014 |
A meta-analysis of the reliability of the history in suspected poisoning.
Topics: Acetaminophen; Acute Disease; Cocaine; Drug Overdose; Humans; Medical History Taking; N-Methyl-3,4-m | 2015 |
Current management of acute liver failure.
Topics: Acetaminophen; Critical Care; Drug Overdose; Hepatic Encephalopathy; Humans; Intracranial Hypertensi | 2015 |
How much did you take? Reviewing acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Drug Dosag | 2015 |
Acetaminophen (paracetamol) oral absorption and clinical influences.
Topics: Acetaminophen; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anima | 2014 |
Intravenous acetaminophen use in pediatrics.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Bicycling; Body Weight; Chemic | 2015 |
Target biomarker profile for the clinical management of paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2015 |
Paracetamol poisoning: beyond the nomogram.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Biomarkers; Drug Overdose; Humans; Nomogram | 2015 |
Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Biomarkers; Cell Death; | 2015 |
Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Drug O | 2015 |
Evidence for the changing regimens of acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Drug Administration Schedule; Drug Overdose; Humans | 2016 |
Liver Failure in Pregnancy.
Topics: Abortion, Therapeutic; Acetaminophen; Critical Care; Drug Overdose; Fatty Liver; Female; HELLP Syndr | 2016 |
Determinants of hepatotoxicity after repeated supratherapeutic paracetamol ingestion: systematic review of reported cases.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2016 |
A clinical and safety review of paracetamol and ibuprofen in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Drug Overdo | 2017 |
Acute liver failure including acetaminophen overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Liver Failure, Acute; Liver Transpla | 2008 |
Too toxic.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Humans; Liver Failure, Acute; Pat | 2008 |
Acetaminophen hepatotoxicity and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Drug Overdose; Drug-Related Side Effects and Adverse Reactions | 2009 |
Paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Benzodiazepines; Charcoal; Drug Overd | 2007 |
[Intravenous or oral N acetylcysteine therapy in paracetamol poisoned patients. Should treatment guidelines be reviewed?].
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Drug Administration S | 2010 |
Critical care management of patients before liver transplantation.
Topics: Acetaminophen; Acetylcysteine; Brain Edema; Drug Overdose; End Stage Liver Disease; Hepatopulmonary | 2010 |
Intravenous acetylcysteine for the treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Antidotes; Chemical and Drug Ind | 2011 |
The therapeutic applications of and risks associated with acetaminophen use: a review and update.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Drug Combinations; Drug Overdose; Humans; | 2011 |
[Intentional paracetamol intoxication in children].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Indu | 2011 |
Management of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Ambulatory Care; Analgesics, Non-Narcotic; Antidotes; Chemical and Dr | 2011 |
Lack of toxicity after paracetamol overdose in a extremely preterm neonate.
Topics: Abdominal Pain; Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced L | 2012 |
Acetaminophen and acetylcysteine dose and duration: past, present and future.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Humans; Multicenter Studies as Topic; United States; U | 2012 |
Acetaminophen and Ibuprofen overdosage.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Chemical and Drug Induced Live | 2012 |
Criteria for acetylcysteine treatment and clinical outcomes after paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Chemical and Drug | 2012 |
A review of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Interactions; Drug Overdose | 2012 |
Combined butalbital/acetaminophen/caffeine overdose: case files of the Robert Wood Johnson Medical School Toxicology Service.
Topics: Acetaminophen; Acetylcysteine; Adult; Barbiturates; Caffeine; Drug Combinations; Drug Overdose; Fema | 2012 |
Low rates of hepatotoxicity among Asian patients with paracetamol overdose: a review of 1024 cases.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Asian People; Chemical and Drug Induced Liver Injury; Drug | 2012 |
[Paracetamol. Efficacious and safe for all ages].
Topics: Acetaminophen; Age Factors; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2013 |
[Management of acute intoxication with paracetamol--Polish Medical Society, Section of Clinical Toxicology position statement].
Topics: Acetaminophen; Drug Overdose; Emergency Medical Services; Humans; Poland | 2012 |
[Severe paracetamol poisoning complicated with liver and renal failure--case report and review of literature].
Topics: Acetaminophen; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver | 2012 |
Molecular Adsorbent Recirculating System (MARS(®)) removal of piperacillin/tazobactam in a patient with acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Dose-Response Relationship, D | 2013 |
Interventions for paracetamol (acetaminophen) overdoses.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans | 2002 |
Paracetamol toxicity: epidemiology, prevention and costs to the health-care system.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Combinations; Drug Costs; Drug Overdose; Drug Packagin | 2002 |
[Treatment of paracetamol intoxication. Correctly given antidote treatment will prevent liver damage].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2002 |
Paracetamol overdose.
Topics: Acetaminophen; Age Factors; Antidotes; Dose-Response Relationship, Drug; Drug Administration Schedul | 2002 |
Management of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Alcoholism; Analgesics, Non-Narcotic; Antidotes; Chemistry, Pharmaceu | 2003 |
[Safety of paracetamol as a representative of nonprescription analgetics-antipyretics].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Drug Overdose; Humans; Li | 2003 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Oral methionine compared with intravenous n-acetyl cysteine for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Evidence-Based Medicine; Hum | 2003 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroida | 2003 |
Acetaminophen intoxication and length of treatment: how long is long enough?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Antidotes; Chemical a | 2003 |
New insights into haemostasis in liver failure.
Topics: Acetaminophen; Acute Disease; Antithrombins; Blood Coagulation Disorders; Blood Coagulation Factors; | 2003 |
[Acetaminophen poisoning].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Charcoal; Drug Overdose; Glutathio | 2003 |
[Tolerability of paracetamol].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Bias; Case-Control Studies; Chemical and Drug Induced Liver | 2003 |
Acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Monitoring; Drug Overdose; | 2004 |
Acetaminophen: the 150 mg/kg myth.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Dose-Response Relation | 2004 |
Restricting paracetamol in the United Kingdom to reduce poisoning: a systematic review.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug and Narcotic C | 2005 |
Co-proxamol and suicide: preventing the continuing toll of overdose deaths.
Topics: Acetaminophen; Age Distribution; Analgesics, Non-Narcotic; Dextropropoxyphene; Drug Combinations; Dr | 2005 |
The safety profile of sustained release paracetamol during therapeutic use and following overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Databases as Topic; Delayed-Acti | 2005 |
Acetaminophen overdose in pregnancy.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2005 |
Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Ster | 2006 |
Interventions for paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antidotes; Charcoal; Drug Overdose; Gastric Lavage; Humans; | 2006 |
Pain control: non-steroidal anti-inflammatory agents.
Topics: Absorption; Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug | 2006 |
[Alcohol abuse case of severe liver dysfunction induced by acetaminophen poisoning which was diagnosed as non-hepatic toxicity on admission].
Topics: Acetaminophen; Acetylcysteine; Administration, Rectal; Adult; Alcoholism; Analgesics, Non-Narcotic; | 2006 |
Pharmaceutical drug overdose.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Arrhy | 2006 |
Repeated supratherapeutic doses of paracetamol in children--a literature review and suggested clinical approach.
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Child; Drug Overdose; Humans; Liver; Risk Facto | 2006 |
Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anaphylaxis; A | 2006 |
Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anaphylaxis; A | 2006 |
Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anaphylaxis; A | 2006 |
Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anaphylaxis; A | 2006 |
Slow the ticking clock of toxicity.
Topics: Acetaminophen; Alcohols; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Drug Overdose; Humans | 2007 |
Impact of restricting paracetamol pack sizes on paracetamol poisoning in the United Kingdom: a review of the literature.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Commerce; Drug Over | 2007 |
Evidence for practice: education about the dangers of acetaminophen.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Drug Combinations; Drug Overdose; Fema | 2007 |
Does therapeutic use of acetaminophen cause acute liver failure?
Topics: Acetaminophen; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; D | 2007 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver | 2007 |
Slow the ticking clock of toxicity.
Topics: Acetaminophen; Alcohols; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Drug Overdose; Ethyle | 2007 |
Best evidence topic reports. Bet 2. Should ondansetron be used as the first-line anti-emetic in paracetamol overdose?
Topics: Acetaminophen; Adult; Antiemetics; Dose-Response Relationship, Drug; Drug Overdose; Evidence-Based M | 2008 |
Guidelines for the management of paracetamol poisoning in Australia and New Zealand--explanation and elaboration. A consensus statement from clinical toxicologists consulting to the Australasian poisons information centres.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Australia; Child; Drug Overdose; Humans; New Zealand | 2008 |
Acute liver failure due to drugs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Drug-Related Side Effects and Adverse Reacti | 2008 |
Acute renal failure due to acetaminophen ingestion: a case report and review of the literature.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Diagnosis, Differential; Drug Overdose; Female; Humans; N | 1995 |
Paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acetylcysteine; Dose-Response Relationship, Drug; Drug Overdose; Humans; Liver; Methi | 1995 |
Special considerations in the poisoned pediatric patient.
Topics: Acetaminophen; Alcoholic Intoxication; Astemizole; Child; Child, Preschool; Clonidine; Cocaine; Crit | 1994 |
Thrombocytopenia following acute acetaminophen overdose.
Topics: Acetaminophen; Adult; Aspartate Aminotransferases; Blood Platelets; Drug Overdose; Humans; Male; Meg | 1994 |
Paracetamol hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatic Enceph | 1993 |
Paracetamol poisoning and the kidney.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Drug Ove | 1993 |
Does acetaminophen damage the heart?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Electrocardiography; Heart; Heart Diseases; | 1996 |
Acute hepatic failure related to chronic acetaminophen intoxication.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Fatal Outcome; Female; Humans; Infant; Liver | 1996 |
Involvement of codeine in drug-related deaths.
Topics: Acetaminophen; Adult; Aged; Cause of Death; Codeine; Drug Overdose; Female; Humans; Incidence; Male; | 1996 |
Classification, etiology, and considerations of outcome in acute liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepa | 1996 |
Acetaminophen use in children: more is not better.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; | 1997 |
Paracetamol-induced acute liver failure: prevention and management.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Extracorporeal Circulation; Hepatic Encephal | 1997 |
Ibuprofen and paracetamol: relative safety in non-prescription dosages.
Topics: Acetaminophen; Aged; Aging; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents | 1997 |
Packaging of drugs and the risk of severe toxicity in adult self-poisonings.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Carbamazepine; Drug Overdose; Drug Packaging; Hong K | 1997 |
Therapeutic misadventures with acetaminophen: hepatoxicity after multiple doses in children.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Biotrans | 1998 |
Ibuprofen, aspirin and acetaminophen toxicosis and treatment in dogs and cats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1998 |
The human and economic cost of paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cost of Illness; Drug Overdose; Humans; Liver Failure, Acut | 1995 |
Treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anti-Ulcer Agents; Antidotes; Charco | 1999 |
Therapeutic drug monitoring in drug overdose.
Topics: Acetaminophen; Anticonvulsants; Digoxin; Drug Monitoring; Drug Overdose; Ethanol; Ethylene Glycol; H | 1999 |
Medical fortune-telling: predicting acetaminophen toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Drug Overdose; Emergency | 1999 |
Acetaminophen intoxication during treatment: what you don't know can hurt you.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Overdo | 2000 |
Phytonadione therapy in a multiple-drug overdose involving warfarin.
Topics: Acetaminophen; Acetylcysteine; Aged; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anticoagulants | 2000 |
Management of drug-induced liver disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cholestasis; Drug O | 2001 |
Use of paracetamol (acetaminophen) for suicide and nonfatal poisoning: worldwide patterns of use and misuse.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug and Narcotic Control; Drug Overdose; Global Health; Hu | 2000 |
[About paracetamol again].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Cimetidine; Drug Overdose; Human | 2001 |
Chronic acetaminophen overdosing in children: risk assessment and management.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Child; Drug Overdose; Expectorants; Humans; | 2001 |
Therapeutic misadventure with paracetamol: fact or fiction?
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Child; Drug Overdose; Humans; Liver | 2000 |
Fulminant hepatic failure due to acetaminophen poisoning may be less common in Hong Kong.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Drug Overdose; Female; Hong Kong; | 2001 |
Management of paracetamol overdose: current controversies.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chi | 2001 |
Poisoning potpourri.
Topics: Acetaminophen; Age Factors; Alcohol Drinking; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac | 2001 |
Therapeutic drug monitoring in drug overdose.
Topics: Acetaminophen; Digoxin; Drug Monitoring; Drug Overdose; Half-Life; Humans; Metabolic Clearance Rate; | 2001 |
Urine drug screening in the medical setting.
Topics: Acetaminophen; Alcoholic Intoxication; Analgesics; Chromatography, Gas; Chromatography, High Pressur | 2002 |
Acute acetaminophen overdose in adolescents and adults.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Age Factors; Antidotes; Critical Ca | 2000 |
Assessment and treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Ove | 1991 |
37 trials available for acetaminophen and Drug Overdose
| Article | Year |
|---|---|
Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5).
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Alanine Transaminase; | 2020 |
A metabolomic analysis of thiol response for standard and modified N-acetyl cysteine treatment regimens in patients with acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; | 2021 |
Effects of nutritional status on acetaminophen measurement and exposure.
Topics: Acetaminophen; Area Under Curve; Cross-Over Studies; Diet, High-Fat; Drug Administration Schedule; D | 2019 |
Paracetamol metabolite concentrations following low risk overdose treated with an abbreviated 12-h versus 20-h acetylcysteine infusion.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Biotransforma | 2019 |
Randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with the 12-h regimen of N-acetylcysteine for paracetamol overdose-the PP100-01 for Overdose of Paracetamol (POP) trial: study protocol for a randomi
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Clinical Trials Data Monitori | 2019 |
MicroRNA from a 12-h versus 20-h acetylcysteine infusion for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; H | 2019 |
Principal results of a randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with a 12 h regimen of N-acetylcysteine for paracetamol overdose (POP trial).
Topics: Acetaminophen; Acetylcysteine; Adult; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Inter | 2019 |
A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Antidotes; Chemical a | 2014 |
Blood gene expression profiling of an early acetaminophen response.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Alanine Transaminase; Analgesics, Non-Narcot | 2017 |
Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Drug Interac | 2008 |
Effect of delayed activated charcoal on acetaminophen concentration after simulated overdose of oxycodone and acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Area Under Curve; Charcoal; Cross-Over | 2009 |
Dose-dependent adsorptive capacity of activated charcoal for gastrointestinal decontamination of a simulated paracetamol overdose in human volunteers.
Topics: Absorption; Acetaminophen; Adsorption; Adult; Antidotes; Charcoal; Dose-Response Relationship, Drug; | 2010 |
Effect of activated charcoal in reducing paracetamol absorption at a supra-therapeutic dose.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Area Under Curve; Charc | 2010 |
N-acetylcysteine as a novel prophylactic treatment for ifosfamide-induced nephrotoxicity in children: translational pharmacokinetics.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adolescent; Analgesics, Non-Narcotic; Animals; A | 2012 |
Acetaminophen-cysteine adducts during therapeutic dosing and following overdose.
Topics: Acetaminophen; Adolescent; Adult; Alcohol Drinking; Alcoholism; Biomarkers; Chemical and Drug Induce | 2011 |
Adverse effects of superactivated charcoal administered to healthy volunteers.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Charcoal; Constipation; Drug Overdose; Femal | 2002 |
Efficacy of superactivated charcoal administered late (3 hours) after acetaminophen overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Body Weight; Charcoal; Drug Overdose; Humans; Multiv | 2003 |
Assessment of a point-of-care test for paracetamol and salicylate in blood.
Topics: Acetaminophen; Adult; Blood Chemical Analysis; Drug Overdose; Female; Humans; Male; Point-of-Care Sy | 2005 |
Pharmacokinetic effects of diphenhydramine or oxycodone in simulated acetaminophen overdose.
Topics: Absorption; Acetaminophen; Analysis of Variance; Area Under Curve; Cross-Over Studies; Diphenhydrami | 2005 |
A randomized clinical trial of activated charcoal for the routine management of oral drug overdose.
Topics: Acetaminophen; Administration, Oral; Adult; Age Factors; Analgesics, Non-Narcotic; Benzodiazepines; | 2005 |
Comparative pharmacokinetics of Panadol Extend and immediate-release paracetamol in a simulated overdose model.
Topics: Absorption; Acetaminophen; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotra | 2006 |
Comparison of urine and serum testing for early detection of acetaminophen ingestion.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Chromatography, High Pressure Liquid; Dr | 2007 |
Effects of PEG-electrolyte (Colyte) lavage on serum acetaminophen concentrations. A model for treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Aged; Blood Glucose; Charcoal; Drug Overdose; Electrolytes; Gastric L | 1993 |
Pharmacokinetics of extended relief vs regular release Tylenol in simulated human overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Biological Availability; Cross-Over Studies; Delayed | 1996 |
Paracetamol self-poisoning. Characteristics, prevention and harm reduction.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Delayed-Action Preparation | 1996 |
A pharmacokinetic comparison of acetaminophen products (Tylenol Extended Relief vs regular Tylenol)
Topics: Acetaminophen; Adult; Area Under Curve; Cross-Over Studies; Delayed-Action Preparations; Double-Blin | 1996 |
Advantage of high-surface-area charcoal for gastrointestinal decontamination in a human acetaminophen ingestion model.
Topics: Absorption; Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Antidotes; Area Un | 1997 |
Efficacy of oral versus intravenous N-acetylcysteine in acetaminophen overdose: results of an open-label, clinical trial.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Chemical | 1998 |
Effect of metoclopramide dose on preventing emesis after oral administration of N-acetylcysteine for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Antiemetics; | 1999 |
Effectiveness of delayed activated charcoal administration in simulated paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Antidotes; Area Under Curve; Charcoal; Cross-Over St | 2000 |
Treatment of acetaminophen ingestion with a superactivated charcoal-cola mixture.
Topics: Absorption; Acetaminophen; Adult; Analgesics, Non-Narcotic; Analysis of Variance; Area Under Curve; | 2001 |
Activated charcoal alone or after gastric lavage: a simulated large paracetamol intoxication.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Charcoal; Chromatography, High Pre | 2002 |
Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Biological Transport; Chemical and Drug Induced Li | 1991 |
Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Child; Drug Overdose; Female; Humans; Injections, | 1991 |
Simulated acetaminophen overdose: pharmacokinetics and effectiveness of activated charcoal.
Topics: Acetaminophen; Adult; Charcoal; Drug Overdose; Humans; Intestinal Absorption; Male; Time Factors | 1991 |
Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Drug Overd | 1991 |
A comparison of the efficacy of gastric lavage, ipecacuanha and activated charcoal in the emergency management of paracetamol overdose.
Topics: Absorption; Acetaminophen; Adolescent; Adult; Charcoal; Drug Overdose; Emergency Medical Services; F | 1990 |
1034 other studies available for acetaminophen and Drug Overdose
| Article | Year |
|---|---|
Integration of transcriptomics and metabolomics confirmed hepatoprotective effects of steamed shoot extracts of ginseng (Panax ginseng C.A. Meyer) on toxicity caused by overdosed acetaminophen.
Topics: Acetaminophen; Amino Acids; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Bile Acids a | 2021 |
Dosing of enteral acetaminophen in critically ill children: a cohort study.
Topics: Acetaminophen; Child; Cohort Studies; Critical Illness; Drug Overdose; Humans; Intensive Care Units, | 2022 |
Evaluation of N-acetylcysteine dose for the treatment of massive acetaminophen ingestion.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2022 |
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Chrysanthem | 2021 |
Decision tree outcome prediction of acute acetaminophen exposure in the United States: A study of 30,000 cases from the National Poison Data System.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Analgesics, Non-Narcotic; Che | 2022 |
Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Fom | 2022 |
A comparison of Australian and New Zealand versus UK hospital referral criteria for the management of supratherapeutic paracetamol ingestion.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Australia; Drug Overdose; Eating; Humans; New Zealand; Refe | 2021 |
Comparing development of liver injury using the two versus three bag acetylcysteine regimen despite early treatment in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induced Liver Inj | 2022 |
Histone demethylase UTX aggravates acetaminophen overdose induced hepatotoxicity through dual mechanisms.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Drug Overd | 2022 |
Serum iron concentrations in non-iron induced acute liver injury.
Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Drug Overd | 2022 |
Large paracetamol overdose - Higher dose NAC is NOT required.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2023 |
Large paracetamol overdose-Higher dose acetylcysteine is required.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2023 |
Prolonged use of paracetamol and the prescribing patterns on rehabilitation facilities.
Topics: Acetaminophen; Aged; Analgesics; Drug Overdose; Frail Elderly; Humans; Retrospective Studies | 2022 |
Acetaminophen Overdose Enhances Early Cholangiocarcinoma in Opisthorchiasis Hamsters.
Topics: Acetaminophen; Animals; Bile Duct Neoplasms; Cholangiocarcinoma; Cricetinae; Drug Overdose; Fishes; | 2021 |
Evaluation of cut-off values in acute paracetamol overdose following the United Kingdom guidelines.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Ov | 2022 |
Accidental intravenous acetaminophen overdose in an infant without development of hepatotoxicity: a case report.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 2022 |
Securing a diagnosis in patients presenting with suspected paracetamol (acetaminophen) poisoning: A retrospective cohort study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; France; Humans; Retrospective Studies | 2022 |
Sensitivity of dose-estimations for acute acetaminophen overdose in predicting hepatotoxicity risk using the Rumack-Matthew Nomogram.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Antidotes; Charcoal; Chemical and Drug Induc | 2022 |
Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury | 2022 |
Activation of the adenosine A2B receptor even beyond the therapeutic window of N-acetylcysteine accelerates liver recovery after an acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Femal | 2022 |
Impact of acetaminophen product labelling changes in Canada on hospital admissions for accidental acetaminophen overdose: a population-based study.
Topics: Acetaminophen; Canada; Drug Overdose; Hospitals; Humans; Product Labeling | 2022 |
Treating acetaminophen overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug | 2022 |
What dose of paracetamol for people with low bodyweight?
Topics: Acetaminophen; Adult; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans | 2022 |
Failure of Risk Assessment After Paracetamol Overdose-A Short Communication.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdos | 2023 |
Comparison of Two-Bag Versus Three-Bag N-Acetylcysteine Regimens for Pediatric Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Child; Cohort | 2023 |
Duloxetine overdose causes sympathomimetic and serotonin toxicity without major complications.
Topics: Acetaminophen; Adult; Antidepressive Agents; Arrhythmias, Cardiac; Coma; Diazepam; Droperidol; Drug | 2022 |
Compromised blood-bile barrier after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Bile; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; D | 2022 |
Changes in Epidemiology of Acetaminophen Overdoses in an Urban County Hospital After 20 Years.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Overdose; Hos | 2022 |
Comment: Comparison of 2-Bag Versus 3-Bag
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chi | 2023 |
SNAPTIMED study: does the Scottish and Newcastle Antiemetic Protocol achieve timely intervention and management from the emergency department to discharge for paracetamol poisoning?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Antiemetics; Drug Overdose; Em | 2023 |
The Toxicology Investigators Consortium Case Registry-the 2021 Annual Report.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Antidotes; COVID-19; Drug Overdose; Fem | 2022 |
Genetic variants associated with ALT elevation from therapeutic acetaminophen.
Topics: Acetaminophen; Adult; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Drug Overdose; F | 2022 |
Population pharmacokinetic analysis of acetaminophen overdose with immediate release, extended release and modified release formulations.
Topics: Acetaminophen; Analgesics, Opioid; Cross-Over Studies; Delayed-Action Preparations; Drug Overdose; H | 2022 |
SNAPTIMED study: does the Scottish and Newcastle Anti-emetic Protocol achieve timely intervention and management from the emergency department to discharge for paracetamol poisoning?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antiemetics; Drug Overdose; Drug-Related Side Effects and A | 2022 |
Comment on: "population pharmacokinetic analysis of acetaminophen overdose with immediate release, extended release and modified release formulations".
Topics: Acetaminophen; Analgesics, Non-Narcotic; Delayed-Action Preparations; Drug Compounding; Drug Overdos | 2023 |
Heroin and fentanyl in Dallas County: A 5-year retrospective review of toxicological, seized drug, and demographical data.
Topics: Acetaminophen; Analgesics, Opioid; Drug Overdose; Fentanyl; Heroin; Humans; Male; Retrospective Stud | 2023 |
Evaluation of the hepatoprotective effect of naringenin loaded nanoparticles against acetaminophen overdose toxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver; Mice; | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COV | 2023 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COV | 2023 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COV | 2023 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COV | 2023 |
Fomepizole should be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side | 2023 |
Fomepizole should be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side | 2023 |
Fomepizole should be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side | 2023 |
Fomepizole should be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side | 2023 |
Paracetamol overdose in children: management following an initial N-acetylcysteine regimen.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Child; Drug Overdose; Drug-Relat | 2023 |
The authors' reply to comment on "Population pharmacokinetic analysis of acetaminophen overdose with immediate release, extended release and modified release formulations".
Topics: Acetaminophen; Analgesics, Non-Narcotic; Delayed-Action Preparations; Drug Compounding; Drug Overdos | 2023 |
Acute kidney injury after treatment of paracetamol overdose using new N-acetylcysteine guideline.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Analgesics, Non-Narcotic; Drug Overdose; Drug-Re | 2023 |
Liver failure cases fall after US clampdown on paracetamol.
Topics: Accidental Falls; Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; D | 2023 |
Implementation of a pharmacist toxicology service on treatment of paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2023 |
Acetaminophen Metabolites on Presentation Following an Acute Acetaminophen Overdose (ATOM-7).
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Australia; Chemical and Drug Induced Liver | 2023 |
The impact on poisonings of up-scheduling of modified release paracetamol to Schedule 3 (pharmacist only medicine).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Medicine; Pharmacists; Poisoning | 2023 |
Early treatment with N-acetylcysteine reduces hepatotoxicity in acute acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; COV | 2023 |
Patterns and outcomes of paracetamol poisoning management in Hamad Medical Corporation, Qatar: A retrospective cohort study.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Drug Overdose; Drug-Related Side Effects and Adver | 2023 |
Paracetamol overdose: limiting the potential for harm.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Australia; Drug Overdose; Drug-Related Side Effects and Adv | 2019 |
Methemoglobinemia associated with massive acetaminophen ingestion: a case series.
Topics: Acetaminophen; Drug Overdose; Fatal Outcome; Female; Humans; Male; Methemoglobin; Methemoglobinemia; | 2020 |
Characteristics, management and outcomes of patients with acute liver failure admitted to Australasian intensive care units.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Australia; Drug Overdose; Female; Humans | 2019 |
Resveratrol Pretreatment Ameliorates p53-Bax Axis and Augments the Survival Biomarker B-Cell Lymphoma 2 Modulated by Paracetamol Overdose in a Rat Model of Acute Liver Injury.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Apoptosis; Asp | 2020 |
Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations.
Topics: Acetaminophen; Adenosylhomocysteinase; Alanine Transaminase; Alcohol Dehydrogenase; Aldehyde Dehydro | 2020 |
Electronic intravenous N-acetyl cysteine ordering tool: A retrospective review.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Electronics; Humans; Retrospective Studies | 2020 |
[Simplified N-acetylcystein treatment after paracetamol overdose - new recommendations from Swedish Poisons Information Centre].
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Antidotes; Drug Overdose; Humans; Poison | 2019 |
Fomepizole as an Adjunctive Treatment in Severe Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2020 |
Use of fomepizole, n-acetylcysteine, and hemodialysis for massive acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Fomepizole; Free | 2020 |
Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Overdos | 2020 |
Letter in response to the Letter to the Editor by Harmouche.
Topics: Acetaminophen; Data Management; Drug Overdose; Humans; Nomograms; Retrospective Studies | 2020 |
Paracetamol for pain in adults.
Topics: Acetaminophen; Drug Overdose; Humans; Osteoarthritis, Knee; Pain; Practice Guidelines as Topic | 2019 |
Adducts Post Acetaminophen Overdose Treated with a 12-Hour vs 20-Hour Acetylcysteine Infusion.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Controlled Cl | 2020 |
Elevated procalcitonin levels in patients with acetaminophen intoxication: two case reports: A CARE-compliant article.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Aspartate Aminotransferases; C-Reactive Protein | 2020 |
The MicroRNA-based Liquid Biopsy Improves Early Assessment of Lethal Acetaminophen Poisoning: A Case Report.
Topics: Acetaminophen; Adult; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Fatal Outco | 2020 |
Suppression of iron mobilization from lysosomes to mitochondria attenuates liver injury after acetaminophen overdose in vivo in mice: Protection by minocycline.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Cell Survival; Cells, Cultu | 2020 |
Acetaminophen in Plasma and Acute Liver Failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Liver Failure, Acute; Plasma | 2020 |
Suspected paracetamol overdose in Monrovia, Liberia: a matched case-control study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Case-Control Studies; Child; Child, Preschool; Drug Overdos | 2020 |
Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Platelets; Cell Membrane Permeability; Cell Res | 2020 |
Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Case-Control Studies; Cell-Free Nucleic Acids; Che | 2020 |
Delayed peaks of acetaminophen in overdose patients with concomitant abdominal trauma.
Topics: Abdominal Injuries; Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug | 2021 |
The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury.
Topics: Acetaminophen; Acute Disease; Animals; Antioxidants; Cytokines; Drug Overdose; Furocoumarins; Gene E | 2020 |
Fomepizole as an adjunctive treatment in severe acetaminophen ingestions: a case series.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug Thera | 2021 |
Comment on Fomepizole as an adjunctive treatment in severe acetaminophen ingestions.
Topics: Acetaminophen; Antidotes; Drug Overdose; Eating; Fomepizole; Humans | 2021 |
The changing face of paracetamol toxicity and new regimens for an old antidote acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Humans | 2021 |
A Case Report of a Severe, Unusually Delayed Anaphylactoid Reaction to Intravenous N-Acetylcysteine During Treatment of Acute Acetaminophen Toxicity in an Adolescent.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anaphy | 2021 |
Authors' reply to Comment on Fomepizole as an adjunctive treatment in severe acetaminophen ingestions.
Topics: Acetaminophen; Antidotes; Drug Overdose; Eating; Fomepizole; Humans | 2021 |
Clinical Progress Note: Goal-Directed N-acetylcysteine Treatment of Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Goals | 2021 |
Identification of factors influencing tampering of codeine-containing medicines in England: a qualitative study.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Analgesics, Opioid; Codeine; Drug Combinatio | 2020 |
Acute liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Critical Care; Drug Overdose; Emergencies; Humans; Liver Fa | 2020 |
Orostachys japonicus ameliorates acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Crassulaceae; Dose-Response Relation | 2021 |
A Mysteriously Low Creatinine Concentration.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Creatinine; Drug Overdose; Female; Humans | 2020 |
Successful orthotopic liver transplantation in a patient with a positive SARS-CoV2 test and acute liver failure secondary to acetaminophen overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; COVID-19; COVID-19 Drug Treatment; Drug Overdose; Fe | 2021 |
National Poison Center Calls Before vs After Availability of High-Dose Acetaminophen (Paracetamol) Tablets in Switzerland.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Presc | 2020 |
Implementation and outcome of an electronic tool for detection of paracetamol overdose in a tertiary care hospital.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Drug Overdose; Electronics; Humans; Retrospective St | 2021 |
Comment on "The changing face of paracetamol toxicity and new regimens for an old antidote acetylcysteine".
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Humans | 2021 |
Paracetamol-related intentional drug overdose among young people: a national registry study of characteristics, incidence and trends, 2007-2018.
Topics: Acetaminophen; Adolescent; Adult; Child; Drug Overdose; Female; Humans; Incidence; Ireland; Male; Re | 2021 |
Sulfate conjugation may be the key to hepatotoxicity in paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 2021 |
The Clinical Value of Routine Acetaminophen Level Screening in Pediatric Patients Presenting to the Emergency Department.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Drug Overdose; Emergen | 2020 |
Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
Topics: Acetaminophen; Animals; Benzoquinones; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cyto | 2021 |
Predicting mortality from acetaminophen poisoning shortly after hospital presentation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induced Liver Injury; Drug Overdo | 2021 |
Clinical outcome of massive acetaminophen overdose treated with standard-dose N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and | 2021 |
A Case Report of Hypoglycemia Following a Tramadol Overdose in a Non-Diabetic Patient.
Topics: Acetaminophen; Analgesics, Opioid; Blood Glucose; Drug Overdose; Humans; Hypoglycemia; Male; Middle | 2022 |
Loss of BOK Has a Minor Impact on Acetaminophen Overdose-Induced Liver Damage in Mice.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; | 2021 |
Routine Laboratory Screening for Acetaminophen and Salicylate Ingestion in Preadmission Psychiatric Patients Is Unnecessary.
Topics: Acetaminophen; Adolescent; Adult; Aged; Diagnostic Tests, Routine; Drug Overdose; Emergency Service, | 2021 |
Clinical Characteristics, Outcomes, Disposition, and Acute Care of Children and Adolescents Treated for Acetaminophen Toxicity.
Topics: Acetaminophen; Adolescent; Child; Child, Preschool; Drug Overdose; Female; Hospitalization; Humans; | 2021 |
Analysis of the Australia and New Zealand referral criteria for transfer to a liver unit for paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Australia; Chemical and Drug Induced Liver Injury; Drug Ove | 2021 |
Paracetamol poisoning: a population-based study from Iceland.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Iceland; Male; Retrosp | 2021 |
Metabolomic markers predictive of hepatic adaptation to therapeutic dosing of acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdo | 2022 |
Intravenous Acetaminophen Overdose in an Infant With Toxicokinetic Data.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans; Infant; Male; Retros | 2023 |
Population pharmacokinetics of immediate-release and modified-release paracetamol and its major metabolites in a supratherapeutic dosing study.
Topics: Acetaminophen; Biological Availability; Cross-Over Studies; Delayed-Action Preparations; Drug Overdo | 2022 |
A Retrospective Review of Hospitalized Patients Receiving a Higher than Maximum Dose of Acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Liver Failure; Patients; Retrospecti | 2023 |
Avoiding aberrant paracetamol prescriptions in paediatric patients.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Child; Drug Overdose; Humans; | 2021 |
Extremely Elevated Procalcitonin in a Case of Acetaminophen Overdose and Acute Liver Injury.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2022 |
Rodenticide ingestion is an important cause of acute hepatotoxicity in Tamil Nadu, southern India.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hum | 2021 |
A two-bag acetylcysteine regimen is associated with shorter delays and interruptions in the treatment of paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Australia; Drug Overdose; Drug-R | 2022 |
Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Cell Proliferation; Chemical and Drug Induced Liv | 2021 |
[Acetaminophen: Knowledge, use and overdose risk in urban patients consulting their general practitioner. A prospective, descriptive and transversal study].
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Cross-Sectional Studies; Drug Misuse; Dr | 2017 |
Limitations of the evidence supporting use of undetectable acetaminophen levels obtained <4 hours post-ingestion to rule out toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans | 2017 |
Reply to: Limitations of the evidence supporting use of undetectable acetaminophen levels obtained <4 hours post-ingestion to rule out toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans | 2017 |
Accuracy of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity in modified-release paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcot | 2017 |
When two is not better than one.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans | 2017 |
Placental Abruption With Delayed Fetal Compromise in Maternal Acetaminophen Toxicity.
Topics: Abruptio Placentae; Acetaminophen; Adult; Analgesics, Non-Narcotic; Cesarean Section; Diagnosis, Dif | 2017 |
Acetylcysteine (Cetylev) for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Antioxidants; Chemica | 2017 |
Bayesian Forecasting Tool to Predict the Need for Antidote in Acute Acetaminophen Overdose.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Antidotes; Baye | 2017 |
Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Computer Simulation; Drug Ove | 2017 |
The standard treatment protocol for paracetamol poisoning may be inadequate following overdose with modified release formulation: a pharmacokinetic and clinical analysis of 53 cases.
Topics: Acetaminophen; Alanine Transaminase; Drug Compounding; Drug Overdose; Female; Humans; Male; Retrospe | 2018 |
Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2).
Topics: Acetaminophen; Acetylcysteine; Adult; Australia; Charcoal; Chemical and Drug Induced Liver Injury; D | 2017 |
Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury.
Topics: Acetaminophen; Adult; Base Sequence; Biomarkers; Case-Control Studies; Chemical and Drug Induced Liv | 2017 |
Evaluation of a Food and Drug Administration Mandate to Limit Acetaminophen in Prescription Combination Products.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induce | 2017 |
Accuracy of the paracetamol-aminotransferase product to predict hepatotoxicity in paracetamol overdose treated with a 2-bag acetylcysteine regimen.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose | 2018 |
The toxicity of paracetamol-codeine combination in overdose is an unresolved issue.
Topics: Acetaminophen; Codeine; Drug Combinations; Drug Overdose; Humans; Respiratory Insufficiency | 2018 |
Toxic Myocarditis Caused by Acetaminophen in a Multidrug Overdose.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antips | 2017 |
Analysis of an 8-hour acetylcysteine infusion protocol for repeated supratherapeutic ingestion (RSTI) of paracetamol.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Australia; Chemical and Drug Induced | 2018 |
Increased acetaminophen related calls to Finnish PIC better reflect acetaminophen sales than serious poisonings.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Commerce; Dru | 2018 |
The use of sustained low efficiency dialysis (SLED) in massive paracetamol overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; D | 2018 |
A comment on 'An assessment of the variation in the concentrations of acetylcysteine in infusions for the treatment of paracetamol overdose'.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Humans | 2017 |
Psychosocial and behavioral factors in acetaminophen-related acute liver failure and liver injury.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Liver F | 2017 |
MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity.
Topics: 3' Untranslated Regions; Acetaminophen; Adolescent; Binding Sites; Cell Line; Child; Child, Preschoo | 2017 |
Notes from the Field: Counterfeit Percocet-Related Overdose Cluster - Georgia, June 2017.
Topics: Acetaminophen; Adult; Aged; Cluster Analysis; Counterfeit Drugs; Drug Combinations; Drug Overdose; F | 2017 |
Suicide by Medication Overdose in Prison: A Study of Three Cases.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Drug Overdose; Fe | 2018 |
Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans.
Topics: Acetaminophen; Cell Line; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Female; HEK2 | 2018 |
Aggressive Treatment of Life-Threatening Hypophosphatemia During Recovery From Fulminant Hepatic Failure: A Case Report.
Topics: Acetaminophen; Adult; Alcoholism; Clinical Protocols; Critical Care; Drug Overdose; Humans; Hypophos | 2018 |
Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies.
Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; | 2018 |
Being overweight or obese as a risk factor for acute liver injury secondary to acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Body Mass Index; Chemical and Drug Induced Liver I | 2018 |
In response to: "Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning".
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Drug Overd | 2018 |
Serum paracetamol-protein adducts in ambulatory subjects: Relationship to recent reported paracetamol use.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Blood Proteins; Cross-Sectional Studies; Dose-Respon | 2018 |
Supra-Therapeutic Oral Paracetamol Overdose in Adults: An Update for the Dental Team.
Topics: Acetaminophen; Administration, Topical; Adult; Algorithms; Analgesics, Non-Narcotic; Drug Overdose; | 2017 |
Intravenous
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Antidotes; Chemical and Drug Induced Liv | 2017 |
Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Chemical and Drug Induced Liver Injury; Drug Over | 2018 |
The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.
Topics: Acetaminophen; Adolescent; Adult; Animals; Chemical and Drug Induced Liver Injury; Disease Models, A | 2017 |
Comment on: Evaluation of a Food and Drug Administration Mandate to Limit Acetaminophen in Prescription Combination Products.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; United States Food and Drug Administ | 2018 |
Availability of Paracetamol Sold Over the Counter in Europe: A Descriptive Cross-Sectional International Survey of Pack Size Restriction.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cross-Sectional Studies; Drug Overdose; Drug Packaging; Eur | 2018 |
[N-acetylcysteine : effective treatment in severe alcoholic hepatitis ?]
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antiviral Agents; Drug Overdose; Hepatitis, | 2018 |
Silymarin prevents acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Liver; Male; Mice; Mi | 2018 |
Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anaphylaxis; Antid | 2018 |
Modified release paracetamol overdose: a prospective observational study (ATOM-3).
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Australia; Charcoal; Chemical and Drug Induced Liver | 2018 |
Bet 1: A slower rate of initial N-acetylcysteine infusion in the treatment of acute paracetamol overdose to reduce adverse reactions.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Antidotes; Drug Overdose; Drug-Related S | 2018 |
Intravenous Paracetamol Overdose: A Pediatric Case Report.
Topics: Acetaminophen; Administration, Intravenous; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartat | 2019 |
Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Animals; Chemical and Drug Induced Liver Injury; Drug | 2018 |
Hepatotoxicity after paracetamol overdose in a patient with cystic fibrosis despite early acetylcysteine and utility of microRNA to predict hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; | 2018 |
In response to: fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Human | 2018 |
Molecular Adsorbent Recirculating System Treatment Can Reduce Blood Levels of N-Acetylcysteine in Patients With Acetaminophen Overdose: Case Reports.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; F | 2018 |
Calculated decisions: Acetaminophen Overdose and N-Acetylcysteine (NAC) Dosing
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Decision Making; Drug Overdose; | 2018 |
Frequency of Poison Center Exposures for Pediatric Accidental Unsupervised Ingestions of Acetaminophen after the Introduction of Flow Restrictors.
Topics: Accidents; Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Drug Overdose; Drug Pac | 2018 |
Systems Toxicology Approach to Identifying Paracetamol Overdose.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; | 2018 |
Dental pain management - a cause of significant morbidity due to paracetamol overdose.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Child; Child, Preschool; Drug Over | 2018 |
Self-medication for dental pain is a major cause of accidental overdose.
Topics: Acetaminophen; Drug Overdose; Humans; Pain Management; Substance-Related Disorders; Toothache | 2018 |
Excessive Plasmin Compromises Hepatic Sinusoidal Vascular Integrity After Acetaminophen Overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2018 |
Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin.
Topics: Acetaminophen; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochro | 2019 |
Overdose due to dental pain.
Topics: Acetaminophen; Drug Overdose; Humans; Pain Management; Toothache | 2018 |
Fewer adverse effects associated with a modified two-bag intravenous acetylcysteine protocol compared to traditional three-bag regimen in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and ov | 2018 |
Epidemiology of paediatric poisoning presenting to a children's emergency department in Singapore over a five-year period.
Topics: Acetaminophen; Adolescent; Adult; Child; Child, Preschool; Critical Care; Drug Overdose; Emergency S | 2018 |
Paracetamol self-poisoning: when oral N-acetylcysteine saves life? a case report.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Antidotes; Drug Overdose; Female; Humans; Suici | 2018 |
Delayed increase in serum acetaminophen concentration after ingestion of a combination medications: a case report.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Combinations; | 2018 |
Long-term outcome in patients with acute liver failure.
Topics: Acetaminophen; Adult; Drug Overdose; Female; Humans; Liver Failure, Acute; Liver Transplantation; Lo | 2018 |
The Effects of Chronic Iron Overload in Rats with Acute Acetaminophen Overdose.
Topics: Acetaminophen; Acute Disease; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Drug Ov | 2018 |
Acetaminophen and Acetylsalicylic Acid Exposure in a Preterm Infant after Maternal Overdose.
Topics: Acetaminophen; Antidepressive Agents; Antidotes; Aspirin; Cystine; Drug Overdose; Female; Humans; In | 2019 |
Transaminase and Creatine Kinase Ratios for Differentiating Delayed Acetaminophen Overdose from Rhabdomyolysis.
Topics: Acetaminophen; Adult; Creatine Kinase; Diagnosis, Differential; Drug Overdose; Female; Humans; Male; | 2018 |
A case report of full recovery from severe cerebral edema secondary to acetaminophen-induced hepatotoxicity in a 13 year old girl.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Brain; Brain Edema; Critical Care; Drug Overdos | 2018 |
Protective effects of p-coumaric acid against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; | 2018 |
Dynamic visualization of the recovery of mouse hepatobiliary metabolism to acetaminophen-overdose damage.
Topics: Acetaminophen; Animals; Biliary Tract; Dose-Response Relationship, Drug; Drug Overdose; Liver; Male; | 2019 |
Poison center exposures due to therapeutic misuse of nonprescription acetaminophen-containing combination products in the United States 2007-2016.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Analgesics, Non-Narcoti | 2019 |
Toxic Ingestion of Acetaminophen and Acetylsalicylic Acid in a Parturient at 33 Weeks Gestation: A Case Report.
Topics: Acetaminophen; Acetylcysteine; Adult; Aspirin; Cesarean Section; Charcoal; Drug Overdose; Female; Fe | 2019 |
An evaluation of the role of mixing techniques in the observed variation in acetylcysteine infusion concentrations.
Topics: Acetaminophen; Acetylcysteine; Dose-Response Relationship, Drug; Drug Compounding; Drug Dosage Calcu | 2019 |
Role of extracellular vesicles in release of protein adducts after acetaminophen-induced liver injury in mice and humans.
Topics: Acetaminophen; Animals; Biomarkers; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury | 2019 |
Relative toxicity of analgesics commonly used for intentional self-poisoning: A study of case fatality based on fatal and non-fatal overdoses.
Topics: Acetaminophen; Adult; Analgesics; Codeine; Dextropropoxyphene; Drug Combinations; Drug Overdose; Eng | 2019 |
Transition to two-bag intravenous acetylcysteine for acetaminophen overdose: a poison center's experience.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Clinical Protocols; Drug Overdos | 2019 |
Changing nomogram risk zone classification with serial testing after acute acetaminophen overdose: a retrospective database analysis.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Canada; Chemi | 2019 |
Acetaminophen is Undetectable in Plasma From More Than Half of Patients Believed to Have Acute Liver Failure Due to Overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdos | 2019 |
Five-year trends in acetaminophen use exceeding the recommended daily maximum dose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Diaries as Topic; Drug Labeling; Drug Overdose; Epid | 2019 |
Overdoses of Acetaminophen Disrupt the Thyroid-Liver Axis in Neonatal Rats.
Topics: Acetaminophen; Animals; Animals, Newborn; Biomarkers; Drug Overdose; Growth and Development; Liver; | 2019 |
Core Entrustable Professional Activities in Clinical Pharmacology for Entering Residency: Common Problem Drugs and How to Prescribe Them.
Topics: Acetaminophen; Adolescent; Adrenal Cortex Hormones; Aged; Anti-Bacterial Agents; Anticoagulants; Con | 2019 |
Video delivery of toxicology educational content versus textbook for asynchronous learning, using acetaminophen overdose as a topic.
Topics: Acetaminophen; Adult; Colorado; Drug Overdose; Education, Medical; Educational Measurement; Emergenc | 2019 |
Protection of mouse brain from paracetamol-induced stress by Centella asiatica methanol extract.
Topics: Acetaminophen; Animals; Astrocytes; Behavior, Animal; Brain; Cells, Cultured; Centella; Disease Mode | 2019 |
Using the 150 rule to prevent hepatotoxicity from acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Diagnosis, Differential; Disease Progression; Drug Overdo | 2019 |
An Unexpected Role of Cholesterol Sulfotransferase and its Regulation in Sensitizing Mice to Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury, Chronic; Disease Mo | 2019 |
Haemodiafiltration as an effective treatment option for massive paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Aged, 80 and over; Analgesics, Non-Narcotic; Antidotes; Drug Overdose | 2019 |
Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose.
Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Case-Control Studies; Drug Overdose; Emer | 2019 |
Hepatotoxicity risk factors and acetaminophen dose adjustment, do prescribers give this issue adequate consideration? A French university hospital study.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Chemical and Drug Induced Li | 2019 |
HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced | 2019 |
The Relationship Between Circulating Acetaminophen-Protein Adduct Concentrations and Alanine Aminotransferase Activities in Patients With and Without Acetaminophen Overdose and Toxicity.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Blood Proteins; Dru | 2019 |
Flow Restrictors and Reduction of Accidental Ingestions of Over-the-Counter Medications.
Topics: Accidents; Acetaminophen; Age Factors; Antitussive Agents; Child, Preschool; Diphenhydramine; Drug O | 2019 |
In response to: "Changing nomogram risk zone classification with serial testing after acute acetaminophen overdose: a retrospective database analysis".
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Nomograms; Retrospective Studies | 2020 |
Paracetamol overdose complicated by posterior reversible encephalopathy syndrome (PRES).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Drug Overdose; Female; Humans; Magnetic Resonance Im | 2020 |
Comment on "What is the most appropriate dose of N acetylcysteine after massive acetaminophen overdose?" by Hendrickson et al.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans | 2020 |
Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen.
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Analgesics, Non-Narcotic; Biomarkers; Chemical and | 2019 |
[Acute renal failure in a healthy 19-year-old woman after intake of 7 g of paracetamol].
Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Drug Overdose; Female; Hospitalization | 2019 |
Letter in response to: "Randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with the 12-h regimen of N acetylcysteine for paracetamol overdose-the PP100-01 for Overdose of Paracetamol (POP) trial: stud
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Edetic Acid; Humans; Pyridoxal Phosphate; Research Des | 2019 |
Access to means of lethal overdose among psychiatric patients with co-morbid physical health problems: Analysis of national suicide case series data from the United Kingdom.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Chronic Disease; Comorbidity; Drug Overdose; England; Fema | 2019 |
Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease.
Topics: Acetaminophen; Adolescent; Adult; Benzoquinones; Circulating MicroRNA; Crystallography, X-Ray; Cytoc | 2019 |
Emerging novel therapies against paracetamol (acetaminophen) hepatotoxicity.
Topics: Acetaminophen; Animals; Antidotes; Antipyretics; Chemical and Drug Induced Liver Injury; Drug Overdo | 2019 |
[Improved and harmonised laboratory analysis of paracetamol provides safer assessment of poisoning cases].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Clinical Laboratory Services; Dr | 2019 |
Dichotomous Role of Plasmin in Regulation of Macrophage Function after Acetaminophen Overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Drug Overd | 2019 |
Comment on "Transition to two-bag intravenous acetylcysteine for acetaminophen overdose".
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans; Poisons | 2020 |
FDA panel recommends tighter rules for prescribing opioids.
Topics: Acetaminophen; Advisory Committees; Analgesics, Opioid; Drug and Narcotic Control; Drug Combinations | 2013 |
Toxbase madness!
Topics: Acetaminophen; Databases, Factual; Drug Overdose; Female; Humans; Toxicology; Young Adult | 2014 |
Validation of ICD-9-CM codes for identification of acetaminophen-related emergency department visits in a large pediatric hospital.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Clinical Coding; Drug | 2013 |
Treating acetaminophen overdose: thresholds, costs and uncertainties.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Cost-Benefit Analysis; Drug Overdose; Healt | 2013 |
Paracetamol overdose in Victoria remains a significant health-care burden.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Au | 2013 |
Bad medicine: co-codamol.
Topics: Acetaminophen; Analgesics, Opioid; Behavior, Addictive; Codeine; Drug Combinations; Drug Overdose; G | 2013 |
The predictive value of hospital admission serum alanine transaminase activity in patients treated for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Ana | 2013 |
The limited utility of screening laboratory tests and electrocardiograms in the management of unintentional asymptomatic pediatric ingestions.
Topics: Acetaminophen; Asymptomatic Diseases; Blood Cell Count; Blood Chemical Analysis; Child; Child, Presc | 2013 |
Curcumin attenuated paracetamol overdose induced hepatitis.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Inj | 2013 |
Davallialactone protects against acetaminophen overdose-induced liver injuries in mice.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Animals; Aspartate Aminotransferases; C | 2013 |
[Acetaminophen (paracetamol) causing renal failure: report on 3 pediatric cases].
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Creatinine; Drug Overdose; Female; Follow-Up Studies | 2013 |
Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice.
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepa | 2013 |
Accidental acetaminophen overdose results in liver transplant during second trimester of pregnancy: a case report.
Topics: Acetaminophen; Adult; Drug Overdose; Female; Humans; Liver Failure; Liver Transplantation; Pregnancy | 2013 |
Preventing paracetamol overdose in children: do we really need a 500 mg/5mL preparation?
Topics: Acetaminophen; Drug Overdose; Drug Packaging; Humans; India | 2013 |
Quality of life is significantly impaired in long-term survivors of acute liver failure and particularly in acetaminophen-overdose patients.
Topics: Acetaminophen; Adult; Coma; Drug Overdose; Female; Follow-Up Studies; Humans; Liver Failure, Acute; | 2013 |
Mathematical modelling of chronic acetaminophen metabolism and liver injury.
Topics: Acetaminophen; Alanine Transaminase; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransfe | 2014 |
Performance of a multi-disciplinary emergency department observation protocol for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Ambulatory Care; Cohort Studies; Drug Overdose; Emergency Serv | 2013 |
How safe is acetaminophen?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2013 |
Subtotal hepatectomy and whole graft auxiliary transplantation for acetaminophen-associated acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; | 2014 |
[Re: medication error in an extremely low birth weight infant: paracetamol overdose].
Topics: Acetaminophen; Drug Overdose; Ductus Arteriosus, Patent; Female; Humans; Infant, Extremely Low Birth | 2013 |
[Author reply].
Topics: Acetaminophen; Drug Overdose; Ductus Arteriosus, Patent; Female; Humans; Infant, Extremely Low Birth | 2013 |
Elevated acetaminophen concentration measured after nasal insufflation of Percocet®.
Topics: Acetaminophen; Acetylcysteine; Administration, Intranasal; Adult; Drug Combinations; Drug Overdose; | 2013 |
Acute overdose: suicide attempt.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Antidotes; Charcoal; Diphenhydramine; Drug Overdose; Educ | 2013 |
Incidence and management of N-acetylcysteine-related anaphylactoid reactions during the management of acute paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Drug Overdose; Female; | 2014 |
Missed paracetamol (acetaminophen) overdose due to confusion regarding drug names.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Delayed Diagnosis; Drug Overdose | 2013 |
Caution with interpreting laboratory results after lipid rescue therapy.
Topics: Acetaminophen; Amitriptyline; Aspartate Aminotransferases; Diphenhydramine; Drug Overdose; False Neg | 2013 |
The epidemiology and management of adult poisonings admitted to the short-stay ward of a large Scottish emergency department.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; | 2013 |
Parental language and dosing errors after discharge from the pediatric emergency department.
Topics: Acetaminophen; Adult; Body Weight; Boston; Child; Child Health Services; Child, Preschool; Communica | 2013 |
Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Biomarkers; Carnitine; Chemical and Drug Induced | 2014 |
Role of bile acids in liver injury and regeneration following acetaminophen overdose.
Topics: Acetaminophen; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestyramine | 2013 |
[Paracetamol overdose].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2013 |
MHRA recommendations on the use of intravenous acetylcysteine in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and ov | 2014 |
Epidemiology, management and outcome of paracetamol poisoning in an inner city emergency department.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anaphylaxis | 2015 |
Negative predictive value of acetaminophen concentrations within four hours of ingestion.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Child; Child, Preschool; Cohort St | 2013 |
Fatalities involving acetaminophen combination products reported to United States poison centers.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Databases, Factual; Dextromethor | 2013 |
Antidote removal during haemodialysis for massive acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; C | 2013 |
Overdosed paracetamol (acetaminophen) prescriptions and subsequent pharmacist interventions in French hospitals.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Weight; Drug Overdose; France; Humans; Medication Erro | 2013 |
Late-onset delirium after an overdose of acetaminophen in a case of benzodiazepine dependence.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Benzodiazepines; Delirium; Drug Overdose; Humans; Ma | 2013 |
Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning.
Topics: Acetaminophen; Aldehyde Oxidase; Allopurinol; Animals; Chemical and Drug Induced Liver Injury; Cyste | 2014 |
Implementation of computerized cumulative acetaminophen dose tracking.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 2014 |
Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans.
Topics: Acetaminophen; Adult; Aged; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; | 2014 |
[Intoxication or false-positive acetaminophen result of toxicological determinations? Two case reports].
Topics: Acetaminophen; Drug Overdose; False Positive Reactions; Female; Humans | 2013 |
Paracetamol poisoning in the UK: a meeting report from Pharmacology 2013.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biomarkers; Drug Overdose; Emergency Service, Hospital; Hum | 2014 |
Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans.
Topics: Acetaminophen; Animals; Argininosuccinate Synthase; Drug Overdose; Humans; Mice; Mice, Inbred C57BL | 2014 |
Identifying adults at risk of paracetamol toxicity in the acute dental setting: development of a clinical algorithm.
Topics: Acetaminophen; Adult; Algorithms; Analgesics, Non-Narcotic; Dental Care; Drug Overdose; Health Knowl | 2014 |
Concealed paracetamol overdose treated as HELLP syndrome in the presence of postpartum liver dysfunction.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cesarean Section; Chemical and Drug Induced Liver In | 2014 |
Impact of new UK paracetamol overdose guidelines on patients presenting to the emergency department.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Drug Overdose; Emergency Service, | 2014 |
Glucose-6-phosphate dehydrogenase deficiency: an unusual cause of acute jaundice after paracetamol overdose.
Topics: Acetaminophen; Acute Disease; Adult; Antipyretics; Drug Overdose; Female; Glucosephosphate Dehydroge | 2014 |
Four-hour acetaminophen concentration estimation after ingested dose based on pharmacokinetic models.
Topics: Acetaminophen; Acetylcysteine; Adult; Age Factors; Antidotes; Child; Drug Overdose; Humans; Models, | 2014 |
Paracetamol toxicity: what would be the implications of a change in Australian treatment guidelines?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Costs and Cost Analysis; Drug Ov | 2014 |
Analysis of electronic medication orders with large overdoses: opportunities for mitigating dosing errors.
Topics: Acetaminophen; Databases as Topic; Drug Overdose; Humans; Infusions, Parenteral; Medical Order Entry | 2014 |
Acetaminophen Psi Nomogram: a sensitive and specific clinical tool to predict hepatotoxicity secondary to acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2014 |
Fatal non-accidental alpha-lipoic acid intoxication in an adolescent girl.
Topics: Acetaminophen; Adolescent; Anti-Obesity Agents; Antioxidants; Critical Care; Drug Overdose; Fatal Ou | 2014 |
[Anorectal necrosis and paracetamol suppository abuse].
Topics: Acetaminophen; Adult; Anal Canal; Anti-Inflammatory Agents, Non-Steroidal; Drug Overdose; Female; Hu | 2014 |
Seeking a role, Psi and APAP×AT as acetaminophen risk assessment tools.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 2014 |
Predicting acute acetaminophen hepatotoxicity with acetaminophen-aminotransferase multiplication product and the Psi parameter.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Antidotes; Aspartate Aminotransferases; | 2014 |
Judge tells trust it can treat minor for paracetamol overdose against her wishes.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Humans; Infor | 2014 |
Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice.
Topics: Acetaminophen; Adiponectin; AMP-Activated Protein Kinases; Analgesics, Non-Narcotic; Animals; Autoph | 2014 |
Liver transplant for intentional acetaminophen overdose and hepatic encephalopathy: a conflict between beneficence and justice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Beneficence; Drug Overdose; Hepatic Encephalopathy; Humans; | 2014 |
Overdose with modified-release paracetamol (Panadol Osteo®) presenting to a metropolitan emergency medicine network: a case series.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Child; Clinical Audit; De | 2014 |
A prescription for pain relief.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Drug Overdose; Female; Hu | 2014 |
[Hepatotoxicity of acetaminophen in a patient treated with capecitabine due to breast cancer].
Topics: Acetaminophen; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Drug | 2014 |
Therapeutic dose of acetaminophen as a possible risk factor for acute kidney injury: learning from two healthy young adult cases.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Biopsy; Dose-Response Relations | 2014 |
An elevated neutrophil-lymphocyte ratio is associated with adverse outcomes following single time-point paracetamol (acetaminophen) overdose: a time-course analysis.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdos | 2014 |
Deadly pain pills: everyday, 46 people in the U.S. die from legal pain pills. Here's how to avoid being a statistic.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Overdos | 2014 |
Awareness, acceptability and application of paracetamol overdose management guidelines in a New Zealand emergency department.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Attitude of Health Personnel; Chil | 2014 |
Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients.
Topics: Acetaminophen; Adult; Biomarkers; Case-Control Studies; Chemical and Drug Induced Liver Injury; Chol | 2014 |
Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Carcinoma, Hepatocellular; Cell | 2015 |
Reported ingested dose of paracetamol as a predictor of risk following paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Hu | 2014 |
Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cohort Studi | 2015 |
Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Adult; Biomarkers; Case-Control Studies; Chemical and Drug Induced Liver Injury; Drug | 2015 |
Hepatoprotective and anti-oxidant activities of Glossogyne tenuifolia against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Antipyretics; | 2014 |
Paracetamol poisonings in the Czech and Slovak Republic and N-acetylcysteine treatment. Data analysis.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Child; Child, P | 2014 |
ABCD: a simple mnemonic for the King's College Hospital criteria in paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Decision Support Te | 2014 |
Preparation of hydrophilic C60(OH)10/2-hydroxypropyl-β-cyclodextrin nanoparticles for the treatment of a liver injury induced by an overdose of acetaminophen.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acetaminophen; Animals; Antioxidants; Benzothiazoles; beta-Cyclod | 2015 |
Paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Indu | 2015 |
Paracetamol overdose.
Topics: Acetaminophen; Analgesics; Drug Overdose; Humans; Poisoning; United Kingdom | 2015 |
Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children.
Topics: Acetaminophen; Adolescent; Biomarkers; Chemical and Drug Induced Liver Injury; Child; Child, Prescho | 2015 |
Acrolein, a highly toxic aldehyde generated under oxidative stress in vivo, aggravates the mouse liver damage after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acrolein; Animals; Blotting, Western; Cell Culture Techniques; Chemic | 2014 |
Paracetamol poisoning in adolescents in an Australian setting: not quite adults.
Topics: Acetaminophen; Adolescent; Adult; Alcohol Drinking; Analgesics, Non-Narcotic; Drug Overdose; Female; | 2015 |
Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure.
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Benzoquinones; Chemica | 2015 |
Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Chemical and Drug Induced Liver Injury; DNA Fragm | 2015 |
Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Blood Proteins; Cell Line; Drug Overdose | 2015 |
An accidental overdose of N-acetylcysteine during treatment for acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Body Weight; Drug Dosage Calcula | 2015 |
Can medical students identify a potentially serious acetaminophen dosing error in a simulated encounter? a case control study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Case-Control Studies; Child, Preschool; Clinical Cle | 2015 |
The role of skeletal muscle in liver glutathione metabolism during acetaminophen overdose.
Topics: Acetaminophen; Animals; Drug Overdose; Glutamic Acid; Glutamine; Glutathione; Liver; Models, Biologi | 2015 |
Confirming the Causative Role of Acetaminophen in Indeterminate Acute Liver Failure Using Acetaminophen-Cysteine Adducts.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Biomarkers; Centrifugation; Cysteine; Dialysis; Drug | 2015 |
Intentional and accidental paracetamol poisoning in childhood - a retrospective analysis.
Topics: Accidents, Home; Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, P | 2015 |
Hepatotoxicity induced by acute and chronic paracetamol overdose in adults. Where do we stand?
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical and Dr | 2015 |
Liver transplant associated with paracetamol overdose: results from the seven-country SALT study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdos | 2015 |
Paracetamol induced liver failure varies widely across Europe, study finds.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fran | 2015 |
Acetaminophen concentrations prior to 4 hours of ingestion: impact on diagnostic decision-making and treatment.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Child; Decision Making; | 2015 |
Public knowledge and factors associated with inappropriate analgesic use: a survey in Thailand.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cross-Sectional Studies; | 2016 |
Case Files from the University of California San Diego Health System Fellowship Coma and Severe Acidosis: Remember to Consider Acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adult; Antidotes; Biomarkers; Coma; Drug Overdose; | 2015 |
Where are we now with paracetamol?
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2015 |
Risk Factors, Clinical Presentation, and Outcomes in Overdose With Acetaminophen Alone or With Combination Products: Results From the Acute Liver Failure Study Group.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; Databases, Factual | 2016 |
External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Bio | 2015 |
Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity.
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Bile Acids and Salts; Biomarkers; Chemical and Drug | 2015 |
Paracetamol overdose in Hong Kong: is the 150-treatment line good enough to cover patients with paracetamol-induced liver injury?
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; | 2015 |
A descriptive analysis of aspartate and alanine aminotransferase rise and fall following acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Antidote | 2015 |
Adverse Drug Reactions in Pediatric Emergency Medicine.
Topics: Acetaminophen; Adolescent; Adverse Drug Reaction Reporting Systems; Amoxicillin; Child; Child, Presc | 2015 |
Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Area Under Curve; Asparta | 2016 |
Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity.
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Ov | 2015 |
Disproportionate effect on child admissions of the change in Medicines and Healthcare Products Regulatory Agency guidance for management of paracetamol poisoning: an analysis of hospital admissions for paracetamol overdose in England and Scotland.
Topics: Acetaminophen; Adolescent; Child; Child, Preschool; Drug Overdose; Hospitalization; Humans; Infant; | 2015 |
Immobilised UGT1A9 may be used to treat paracetamol overdose.
Topics: Acetaminophen; Benzoquinones; Drug Overdose; Enzymes, Immobilized; Glucuronosyltransferase; Hepatocy | 2015 |
Summary of: Paracetamol overdose secondary to dental pain: a case series.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Male; Pain Management; Tooth | 2015 |
Paracetamol overdose secondary to dental pain: a case series.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Drug Overdose; England; Female; Hospital | 2015 |
Global research productivity of N-acetylcysteine use in paracetamol overdose: A bibliometric analysis (1976-2012).
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Bibliometrics; Biomedical Re | 2015 |
Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; AMP-Activated Protein Kinases; Animals; | 2015 |
A novel approach for estimating ingested dose associated with paracetamol overdose.
Topics: Acetaminophen; Computer Simulation; Dose-Response Relationship, Drug; Drug Overdose; Humans; Models, | 2016 |
Management of acute paracetamol poisoning.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipyretics; Drug Overdose; Humans | 2015 |
Paracetamol overdose: relevance of recent evidence for managing patients in Sri Lanka.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dis | 2015 |
Trends in rates of acetaminophen-related adverse events in the United States.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; | 2016 |
Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose: a Response.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and D | 2016 |
Nomogram line crossing after acetaminophen combination product overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid | 2016 |
High-visibility warning labels on paracetamol-containing products do not prevent supratherapeutic ingestion in a simulated scenario.
Topics: Acetaminophen; Adult; Aged; Australia; Consumer Health Information; Drug Labeling; Drug Overdose; Dr | 2015 |
In Response to: "Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose.".
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and D | 2016 |
Simplification of the standard three-bag intravenous acetylcysteine regimen for paracetamol poisoning results in a lower incidence of adverse drug reactions.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Anaphylaxis; Drug Ove | 2016 |
Highlight report: acetaminophen hepatotoxicity.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2015 |
New regimens for intravenous acetylcysteine, where are we now?
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Antiemetics; Drug Overdose; Endpoint Det | 2016 |
Relation of Health Literacy to Exceeding the Labeled Maximum Daily Dose of Acetaminophen.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Drug Labeling; Drug Overdose; Female; Health Knowled | 2016 |
A prospective observational study of a novel 2-phase infusion protocol for the administration of acetylcysteine in paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Che | 2016 |
Safety Issues Regarding Prescription Opioids.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Combinations; Drug Overdose; Drug | 2016 |
Acute hepatotoxicity associated with therapeutic doses of intravenous acetaminophen.
Topics: Acetaminophen; Administration, Intravenous; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical an | 2016 |
Protective effect of hyperoside against acetaminophen (APAP) induced liver injury through enhancement of APAP clearance.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Overdo | 2016 |
Medication Overdoses at a Public Emergency Department in Santiago, Chile.
Topics: Acetaminophen; Adult; Alcohol Drinking; Ambulatory Care; Analgesics, Non-Narcotic; Antidepressive Ag | 2016 |
Summary statement: new guidelines for the management of paracetamol poisoning in Australia and New Zealand.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antidotes; Australia; Charcoal; Child; Drug Overdose; Human | 2015 |
How to treat paracetamol overdose and when to do it.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Hum | 2016 |
Potential adjunct treatment for high-risk acetaminophen overdose.
Topics: Acetaminophen; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1 Inhibi | 2016 |
ACMT Position Statement: Duration of Intravenous Acetylcysteine Therapy Following Acetaminophen Overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antioxidants; Clinical Decision-Making; Dru | 2017 |
Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cochlea; Drug | 2016 |
[A prospective study on suicide attempts by self-poisoning in adolescents: Symptoms and complications].
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Charcoal; Child; Drug Overdose; Emergency Servi | 2016 |
Diagnostics: Cluster headache and misuse of paracetamol.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cluster Headache; Drug Overdose; Humans; Male | 2016 |
Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adult; Alanine Transaminase; Antidotes; | 2016 |
Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adolescent; Coma; Drug Overdose; Emergency Service, | 2016 |
Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21, -200c, and -423.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Biomarkers; Case-Control Studies; Cells, Cultured; Cispla | 2016 |
Liver-Specific Deletion of Integrin-Linked Kinase in Mice Attenuates Hepatotoxicity and Improves Liver Regeneration After Acetaminophen Overdose.
Topics: Acetaminophen; Animals; beta Catenin; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E | 2016 |
[Clinical pharmacist influence at hospital to prevent overdosed prescription of acetaminophen].
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical and Dr | 2016 |
Treatments for paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Drug Overdose; Female; | 2016 |
N-acetylcysteine regimens for paracetamol overdose: Time for a change?
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Analgesics, Non-Narcotic; Antidotes; Dru | 2016 |
Elucidation of the hepatoprotective moiety of 5β-scymnol that suppresses paracetamol toxicity in mice.
Topics: Acetaminophen; Animals; Cholestanols; Drug Overdose; Glutathione; Liver; Male; Mice | 2016 |
[Good use and knowledge of paracetamol (acetaminophen) among self-medicated patients: Prospective study in community pharmacies].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Body Weight; Chemical and Drug Induced Liver Injury; | 2016 |
Mechanistic study of TRPM2-Ca(2+)-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition.
Topics: Acetaminophen; Animals; Autophagy; Beclin-1; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependen | 2016 |
Electroconvulsive Therapy in the Setting of Acute, Deliberate, Acetaminophen Overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Bipolar Disorder; Drug Overdose; Electroconvulsive T | 2016 |
Guidance on acetylcysteine for paracetamol ingestion needs review.
Topics: Acetaminophen; Acetylcysteine; Analgesics; Antidotes; Drug Overdose; Health Services Needs and Deman | 2016 |
Authors' reply to Thomas and colleagues.
Topics: Acetaminophen; Acetylcysteine; Analgesics; Antidotes; Dissent and Disputes; Drug Overdose; Humans; P | 2016 |
Care versus convenience: Examining paracetamol overdose in New Zealand and harm reduction strategies through sale and supply.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Aged; Analgesics, Non-Narcotic; Drug Overdose; E | 2015 |
The pharma-fever that almost got away.
Topics: Acetaminophen; Aged; Analgesics, Opioid; Antipyretics; Carcinoma, Non-Small-Cell Lung; Drug Overdose | 2016 |
A study on paracetamol cardiotoxicity.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Cardiotoxicity; Cross-Sectional Studies; | 2016 |
Delays during the administration of acetylcysteine for the treatment of paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Antidotes; Drug Administration Schedule; Drug Over | 2016 |
Paracetamol overdosing in a tertiary care hospital: implementation and outcome analysis of a preventive alert programme.
Topics: Acetaminophen; Drug Overdose; Drug Prescriptions; Electronic Prescribing; Humans; Medical Order Entr | 2016 |
Hepatotoxicity induced by acute and chronic paracetamol overdose in children: Where do we stand?
Topics: Acetaminophen; Acute Disease; Adolescent; Age Distribution; Analgesics, Non-Narcotic; Chemical and D | 2017 |
Ocfentanil overdose fatality in the recreational drug scene.
Topics: Acetaminophen; Adolescent; Caffeine; Chromatography, Liquid; Drug Overdose; Fatal Outcome; Humans; I | 2016 |
Detection of Acetaminophen-Protein Adducts in Decedents with Suspected Opioid-Acetaminophen Combination Product Overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; | 2016 |
Incidence and characterization of acute kidney injury after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Biomarkers; Cre | 2016 |
[A Case of Acetaminophen Poisoning Associated with Tramcet Overdose].
Topics: Acetaminophen; Acetylcysteine; Adolescent; Drug Overdose; Female; Humans; Tramadol; Treatment Outcom | 2016 |
Non-accidental non-fatal poisonings attended by emergency ambulance crews: an observational study of data sources and epidemiology.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Cross-Sectional Studies; Drug Overdose; | 2016 |
An assessment of the variation in the concentration of acetylcysteine in infusions for the treatment of paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chromatography, High Pressure Li | 2017 |
When voluntary paracetamol overdose requires a drug challenge.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans | 2016 |
Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients.
Topics: Acetaminophen; Adult; Aged; Animals; Biomarkers; Blood Chemical Analysis; Carbon Tetrachloride; Chem | 2016 |
Acrolein scavengers, cysteamine and N-benzylhydroxylamine, reduces the mouse liver damage after acetaminophen overdose.
Topics: Acetaminophen; Acrolein; Animals; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Cysteami | 2017 |
Analysis of Gastric Lavage Reported to a Statewide Poison Control System.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; | 2016 |
Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress.
Topics: Acetaminophen; Animals; Apoptosis; bcl-2-Associated X Protein; Chemical and Drug Induced Liver Injur | 2017 |
Hemolytic crisis following acetaminophen overdose in a patient with G6PD deficiency.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anemia, Hemolytic; Drug Overdose; Female; Glucosepho | 2017 |
Characterisation and outcomes of adult patients with paracetamol overdose presenting to a tertiary hospital in Singapore.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Anaphylaxis; Drug Overdose; Female; Humans; | 2017 |
Massive paracetamol overdose associated with mitochondrial dysfunction and pancytopenia, without hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Emergency Service, Hospital; Female; Humans; | 2016 |
Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Antiemetics; A | 2017 |
Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Connexins; Cytokines; Drug Overdose; | 2017 |
[Overdose of modified-release paracetamol calls for changed treatment routines. New guidelines from the Swedish Poisons Information Centre].
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Delayed-Action Preparatio | 2016 |
Serum Acetaminophen Protein Adduct Concentrations in Pediatric Emergency Department Patients.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver Injury; Child; | 2017 |
Different effects of selective β1-adrenoceptor antagonists, nebivolol or atenolol in acetaminophen-induced hepatotoxicity of rats.
Topics: Acetaminophen; Adrenergic beta-1 Receptor Antagonists; Analgesics, Non-Narcotic; Animals; Antioxidan | 2017 |
In this December issue.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Clinical Competence; Drug Overdose; Emerg | 2016 |
Acetaminophen overdoses, active component, U.S. Armed Forces, 2006-2015.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Liver; Ma | 2016 |
Outcomes from massive paracetamol overdose: a retrospective observational study.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Asp | 2017 |
The Headache of Acetaminophen Overdose: Getting the NAC.
Topics: Acetaminophen; Drug Overdose; Headache; Humans; Immunoassay; Liver | 2017 |
Lack of respiratory depression in paracetamol-codeine combination overdoses.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Child; Codeine | 2017 |
Inhibition of Glycogen Synthase Kinase 3 Accelerated Liver Regeneration after Acetaminophen-Induced Hepatotoxicity in Mice.
Topics: Acetaminophen; Animals; beta Catenin; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cy | 2017 |
ERK Signaling Pathway Plays a Key Role in Baicalin Protection Against Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No | 2017 |
Increased availability of paracetamol in Sweden and incidence of paracetamol poisoning: using laboratory data to increase validity of a population-based registry study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Child; Child, Preschool; Cohort St | 2017 |
Haemodialysis in acute paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Analgesics, Non-Narcotic; Chemical and Drug Induced | 2017 |
Acute liver failure in Scotland: changes in aetiology and outcomes over time (the Scottish Look-Back Study).
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cohort Studies; Drug Overdose; Female; Hepatic Encep | 2017 |
New aspects on the hepatoprotective potential associated with the antioxidant, hypocholesterolemic and anti-inflammatory activities of Vernonia condensata Baker.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Antioxidants; Cell Line; | 2017 |
Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Drug Overd | 2017 |
Response to Consumer Healthcare Products Association letter to "Trend in rates of acetaminophen-related adverse events in the United States".
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; United States | 2017 |
Should we treat very large paracetamol overdose differently?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Humans | 2017 |
Coricidin HBP abuse: patient characteristics and psychiatric manifestations as recorded in an inpatient psychiatric unit.
Topics: Acetaminophen; Adolescent; Age Factors; Alcoholism; California; Child; Chlorpheniramine; Comorbidity | 2008 |
Evaluation of a urine screen for acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chromatography, High Pressure Liquid; Drug Overdose; Fluoro | 2008 |
Correlation of paired plasma and saliva paracetamol levels following deliberate self-poisoning with paracetamol (the Salivary Paracetamol In Toxicology [SPIT] study).
Topics: Acetaminophen; Adolescent; Adult; Colorimetry; Drug Overdose; Emergency Service, Hospital; Female; H | 2008 |
Acetaminophen-induced acute liver failure treated with single-pass albumin dialysis: report of a case.
Topics: Acetaminophen; Adult; Albumins; Analgesics, Non-Narcotic; Dialysis; Dialysis Solutions; Drug Overdos | 2008 |
Acetaminophen overdose with altered acetaminophen pharmacokinetics and hepatotoxicity associated with premature cessation of intravenous N-acetylcysteine therapy.
Topics: Acetaminophen; Acetylcysteine; Aged; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Rad | 2008 |
Dextropropoxyphene: welcome withdrawal from a French hospital's formulary.
Topics: Acetaminophen; Analgesics, Opioid; Dextropropoxyphene; Drug Overdose; Drug Therapy, Combination; Dru | 2008 |
[Acute acetaminophen overdose].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2008 |
Successful kidney transplants from a donor with acute hepatic failure due to acetaminophen overdose and acute kidney injury.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Death; Drug Overdose; Female; Graft Survival; | 2008 |
[Accidental acetaminophen overdose].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema | 2008 |
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2008 |
Cardiac arrest following therapeutic administration of N-acetylcysteine for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Drug Overd | 2008 |
Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Blood Coagul | 2008 |
High dose acetaminophen in narcotic combinations: should there be concern?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; | 2008 |
Hepatitis C is a predictor of acute liver injury among hospitalizations for acetaminophen overdose in the United States: a nationwide analysis.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Health Surveys; Hepatitis C; | 2008 |
Effect of crude sulphated polysaccharide from brown algae against acetaminophen-induced toxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blood Glucose; Cell Death; Drug Overdose; Globulin | 2008 |
Acetaminophen-associated hepatic injury: evaluation of acetaminophen protein adducts in children and adolescents with acetaminophen overdose.
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Bayes Theorem; Biomark | 2008 |
[Therapeutic misadventure with acetaminophen in alcoholics].
Topics: Acetaminophen; Alcoholism; Drug Overdose; Humans | 2009 |
Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate | 2009 |
A case of nonoliguric acute kidney injury associated with acetaminophen overdose.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; Hu | 2008 |
Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Aged; Alanine Transaminase; Analgesics, Non-Nar | 2009 |
Acute hepatic failure in an infant caused by acetaminophen (paracetamol) toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Diagnosis, Differential; Drug Overdose; Fatal Outcome; Hepa | 2008 |
Proteinuria is unrelated to the extent of acute acetaminophen overdose: a prospective clinical study.
Topics: Acetaminophen; Adolescent; Adult; Albuminuria; Analgesics, Non-Narcotic; Case-Control Studies; Creat | 2008 |
Serum acetaminophen concentrations after acute overdose are not altered by opioid co-ingestion.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Int | 2008 |
Window of opportunity: flexion myelopathy after drug overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Antipsychotic Agents; Chloral Hydrate; Dibenzothiaze | 2012 |
Comment: frequency of medication errors with intravenous acetylcysteine for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Humans; Infusions, Intravenous; Medication Errors; Tim | 2009 |
Circulating microRNAs, potential biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Rela | 2009 |
Circulating microRNAs, potential biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Rela | 2009 |
Circulating microRNAs, potential biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Rela | 2009 |
Circulating microRNAs, potential biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Rela | 2009 |
Hepatotoxicity in an infant following supratherapeutic dosing of acetaminophen for twenty-four hours.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate | 2009 |
Dextropropoxyphene withdrawal from a French university hospital: impact on analgesic drug consumption.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Dextropropoxyphene; Drug Overdose; Drug Therapy | 2009 |
Hepatitis C, alcohol abuse, and unintentional overdoses are risk factors for acetaminophen-related hepatotoxicity.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induced Liver Injury; | 2009 |
Hospital admission for non-fatal poisoning with weak analgesics and risk for subsequent suicide: a population study.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Cause of D | 2009 |
Prolonged treatment with N-acetylcystine delays liver recovery from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antidotes; Aspartate Aminotr | 2009 |
Paracetamol poisoning below toxic level causing liver damage in a fasting adult.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2009 |
Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquino | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquino | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquino | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquino | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquino | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquino | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquino | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquino | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquino | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquino | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquino | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquino | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquino | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquino | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquino | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquino | 2009 |
Thinking through acetaminophen hepatotoxicity and liver transplantation: choosing worthy recipients.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Drug Overdose; Humans; Kaplan-Meier Estimate; L | 2009 |
The utilization of liver transplantation in the management of acute liver failure: comparison between acetaminophen and non-acetaminophen etiologies.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; Analgesics, Non-Narcotic; Cohort Studies; Contra | 2009 |
Prolonged N-acetylcysteine therapy in late acetaminophen poisoning associated with acute liver failure--a need to be more cautious?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Drug Administration Sch | 2009 |
Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Antidotes; Canada; Chemical | 2009 |
Acetaminophen overdose in Jamaica.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Jamaica; | 2008 |
Limiting paracetamol pack size: has it worked in the UK?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Canada; Commerce; Dose-Response Relationship, Drug; Drug Ov | 2009 |
Overdose of methyldopa, indapamide and theophylline resulting in prolonged hypotension, marked diuresis and hypokalaemia in an elderly patient.
Topics: Acetaminophen; Aged, 80 and over; Analgesics, Non-Narcotic; Antihypertensive Agents; Combined Modali | 2009 |
[Acute renal failure after acetaminophen poisoning: report of three cases].
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics, Non-Narcotic; Anuria; Creatinine; | 2009 |
Gift of the glob--is it foolproof?
Topics: Acetaminophen; Adult; Antipsychotic Agents; Diazepam; Dibenzothiazepines; Drug Overdose; Fat Emulsio | 2009 |
Detailed analyses of self-poisoning episodes presenting to a large regional teaching hospital in the UK.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Drug Overdose; Emergency Service, Hospita | 2009 |
Is the oral acetylcysteine protocol the best treatment for late-presenting acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Chemical and Drug Induced Liver Injury; Drug Ov | 2009 |
Early presentation following overdose of modified-release paracetamol (Panadol Osteo) with biphasic and prolonged paracetamol absorption.
Topics: Acetaminophen; Acetylcysteine; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Amino | 2009 |
Acetaminophen-induced acute pancreatitis. A case report.
Topics: Acetaminophen; Acidosis; Adult; Drug Overdose; Female; Humans; Pancreatitis | 2009 |
The FDA Acetaminophen Advisory Committee Meeting - what is the future of acetaminophen in the United States? The perspective of a committee member.
Topics: Acetaminophen; Advisory Committees; Analgesics, Non-Narcotic; Congresses as Topic; Consumer Product | 2009 |
European Medicines Evaluation Agency bans dextropropoxyphene: a landmark decision for clinical toxicology?
Topics: Acetaminophen; Analgesics, Opioid; Consumer Product Safety; Dextropropoxyphene; Drug and Narcotic Co | 2009 |
. . . FDA may limit sales of acetaminophen-containing medications. . .
Topics: Acetaminophen; Drug Overdose; Humans; Medication Errors; Nonprescription Drugs; United States; Unite | 2009 |
Delayed onset of acute renal failure after significant paracetamol overdose: A case series.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Alanine Transaminase; Analgesics, Non-Narcoti | 2010 |
Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Energ | 2010 |
Managing acute acetaminophen poisoning with oral versus intravenous N-acetylcysteine: a provider-perspective cost analysis.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Antido | 2009 |
A difficult balance--pain management, drug safety, and the FDA.
Topics: Acetaminophen; Advisory Committees; Analgesics; Analgesics, Opioid; Drug and Narcotic Control; Drug | 2009 |
Regarding "comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning" by Yarema et al.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Drug Administration S | 2009 |
IV versus oral N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Chemical and Drug Ind | 2009 |
Is acetaminophen safe? Accidental overdoses are common, but avoidable.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Labeling; Drug | 2010 |
Long-term outcome following liver transplantation for paracetamol overdose.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Graft Survival; H | 2010 |
Acetaminophen: old drug, new warnings.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Drug Labeling; Drug Overd | 2010 |
Incidence of adverse drug reactions induced by N-acetylcysteine in patients with acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Analgesic | 2010 |
Intravenous paracetamol overdose in a preterm infant during anesthesia.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Free Radical Scavengers; Her | 2010 |
Cost minimization analysis comparing enteral N-acetylcysteine to intravenous acetylcysteine in the management of acute acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Aged; Analgesics, Non-Narcotic; Antidote | 2010 |
High prevalence of hypokalemia after acute acetaminophen overdose: impact of psychiatric illness.
Topics: Acetaminophen; Adjustment Disorders; Adolescent; Adult; Anxiety Disorders; Cohort Studies; Depressiv | 2010 |
Massive acetaminophen ingestion with early metabolic acidosis and coma: treatment with IV NAC and continuous venovenous hemodiafiltration.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Analgesics, Non-Narcotic; Antidotes; Coma; Combined Modalit | 2010 |
Use of analgesics in intentional drug overdose presentations to hospital before and after the withdrawal of distalgesic from the Irish market.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Child; Child, Preschool; Dextropropoxyphene; Dru | 2010 |
Late extensive intravenous administration of N-acetylcysteine can reverse hepatic failure in acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug In | 2011 |
[Treatment of paracetamol poisoning to revision].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans; Poisoning; Practice | 2010 |
Reliability of history of acetaminophen ingestion in intentional drug overdose patients.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Child; Drug Ove | 2011 |
Relationship between serum acetaminophen concentration and N-acetylcysteine-induced adverse drug reactions.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose | 2010 |
High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Ulcer Agents; Antidotes; Brain; Dose-Response | 2010 |
Cost of the paracetamol overdose epidemic.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans; Methionine; Sri Lank | 2010 |
The role of prostaglandin E2 in acute acetaminophen hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Cytoprotection; Dinoprostone; Drug Overdose; Drug-Rela | 2010 |
A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Drug Administration Routes; Drug Overdose; Humans; Infus | 2010 |
Overdose with modified-release paracetamol results in delayed and prolonged absorption of paracetamol.
Topics: Absorption; Acetaminophen; Adult; Delayed-Action Preparations; Drug Overdose; Female; Humans; Male; | 2010 |
N-acetylcysteine-induced headache in hospitalized patients with acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Cohort Studies; Drug Overdose; Female; Headache; Hospitali | 2011 |
[Are nomograms available for the treatment of acetaminophen poisoning? Pros: usefullness of nomogram-based decision-making in the treatment of acute acetaminophen overdose in Japan: single center experience with 61 consecutive patients in Niigata City Gen
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Biomarkers; Chemical and Drug Induc | 2010 |
An analysis of the length of hospital stay after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Costs and Cost Analysis; Drug Ov | 2011 |
Effects of delay in infusion of N-acetylcysteine on appearance of adverse drug reactions after acetaminophen overdose: a retrospective study.
Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Antidotes; Drug Overdose; Female; Humans; Male; R | 2010 |
Enhanced paracetamol clearance with molecular adsorbents recirculating system (MARS®) in severe autointoxication.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Middle Aged; Sorption Detoxi | 2010 |
The case for limiting acetaminophen-related deaths: smaller doses and unbundling the opioid-acetaminophen compounds.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; | 2010 |
A cross-sectional observation of the factors associated with deliberate self-poisoning with acetaminophen: impact of gender differences and psychiatric intervention.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Antidepressive Agents; Cross-Sectional Studies; Depre | 2010 |
For the dental patient ... Acetaminophen overdose and liver damage.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug | 2010 |
Molecular mechanisms of Id2 down-regulation in rat liver after acetaminophen overdose. Protection by N-acetyl-L-cysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Cytoprotection; Down-Regulation; D | 2010 |
Overdoing acetaminophen. Many overdoses are accidental, so the FDA may require new warnings on the popular pain reliever and lower the daily limit.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; D | 2009 |
Early anion gap metabolic acidosis in acetaminophen overdose.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis, Lactic; Adult; Analgesics, Non-Narcotic; Analysis of | 2010 |
Response to "A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose".
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Drug Overdose; Humans; Injections, Intravenous | 2010 |
The clinical management of acetaminophen poisoning in a community hospital system: factors associated with hospital length of stay.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Antidotes; Cal | 2011 |
Clinical cases in acute intoxication.
Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Central Nervous Sy | 2009 |
Advanced directives and suicidal behaviour. "If in doubt treat" is not as easy as it sounds.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Mental Competency; Mental Disorders; | 2010 |
Multiplying the serum aminotransferase by the acetaminophen concentration to predict toxicity following overdose.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Aspartate Aminotransferases; Cohort Studies; Dr | 2010 |
Dental pain as a risk factor for accidental acetaminophen overdose: a case-control study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Case-Control St | 2011 |
When do the aminotransferases rise after acute acetaminophen overdose?
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransfe | 2010 |
Intravenous paracetamol overdose: two case reports and a change to national treatment guidelines.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2011 |
Understanding lactic acidosis in paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acidosis, Lactic; Drug Overdose; Female; Humans; Liver Failure, Acute; Male; Prognosi | 2011 |
Why not formulate an acetaminophen tablet containing N-acetylcysteine to prevent poisoning?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemistry, Pharmaceutical; Delay | 2011 |
"Massive acetaminophen ingestion with early metabolic acidosis and coma: treatment with iv nac and continuous venovenous hemodiafiltration" by Wiegand et al., Clin Toxicol (Phila) 48:156-159.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Analgesics, Non-Narcotic; Coma; Drug Overdose; Half-Life; H | 2010 |
Injectable paracetamol in children: fatal confusion between milligrams and millilitres.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Infant; Infant, Newborn; Injections; | 2010 |
ST segment elevation secondary to paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Aged; Analgesics, Non-Narcotic; Antidotes; Coronary Angiography; Drug | 2011 |
Overdose pattern and outcome in paracetamol-induced acute severe hepatotoxicity.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Contraindications; Drug Overdose; Epidemiologi | 2011 |
The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2011 |
A gargantuan acetaminophen level in an acidemic patient treated solely with intravenous N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; | 2013 |
Impact of serum acetaminophen concentration on changes in serum potassium, creatinine and urea concentrations among patients with acetaminophen overdose.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Biomarkers; Child; Child, Preschool; Cre | 2011 |
Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Bilirubin; Chemical and Drug Induced | 2011 |
Emergent, controlled lumbar drainage for intracranial pressure monitoring during orthotopic liver transplantation.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Edema; Drainage; Drug Overdose; Female; Follow | 2011 |
Detection of acetaminophen-cysteine adducts in cases of indeterminate liver failure is not diagnostic of intentional overdose.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cysteine; Drug Overdose; Humans; Liver Failur | 2011 |
Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Child; Cholinergic An | 2011 |
Double peak and prolonged absorption after large acetaminophen extended release and diphenhydramine ingestion.
Topics: Acetaminophen; Adult; Delayed-Action Preparations; Diphenhydramine; Drug Overdose; Female; Humans; P | 2012 |
Intravenous paracetamol--an international perspective of toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Injections, Intravenous; Internation | 2011 |
Fatal outcome of a propoxyphene/acetaminophen (Darvocet) overdose: should it still be used in the United States?
Topics: Acetaminophen; Adult; Dextropropoxyphene; Drug Combinations; Drug Overdose; Fatal Outcome; Female; H | 2011 |
Self-treatment of acetaminophen overdose with dietary-supplement acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Dietary Supplements; Drug | 2011 |
FDA limits prescription acetaminophen. But be vigilant about over-the-counter acetaminophen, too.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 2011 |
The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Liver Failure, Acute; | 2011 |
Overdose with suicidal intent: ethical considerations for liver transplant programs.
Topics: Acetaminophen; Adult; Drug Overdose; Ethics, Medical; Female; Humans; Liver Failure, Acute; Liver Tr | 2011 |
Emergency department visits for overdoses of acetaminophen-containing products.
Topics: Acetaminophen; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Aged, | 2011 |
Developing consumer-centered, nonprescription drug labeling a study in acetaminophen.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Commun | 2011 |
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Blotting, Western; Chemical and Drug Induced Live | 2011 |
Impact of withdrawal of the analgesic Co-proxamol on nonfatal self-poisoning in the UK.
Topics: Acetaminophen; Analgesics; Cross-Sectional Studies; Dextropropoxyphene; Drug Combinations; Drug Over | 2011 |
Acetaminophen overdose-induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D-regulated permeability transition.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclophili | 2011 |
Impact of different pack sizes of paracetamol in the United Kingdom and Ireland on intentional overdoses: a comparative study.
Topics: Acetaminophen; Adolescent; Adult; Child; Drug Overdose; Drug Packaging; Female; Humans; Ireland; Mal | 2011 |
Encephalopathy in acute liver failure resulting from acetaminophen intoxication: new observations with potential therapy.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Diseases; Chemical and Drug Induced Liver Inju | 2011 |
Misuse of acetaminophen in the management of dental pain.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hum | 2011 |
Complex suicide: self-incineration and acetaminophen overdose.
Topics: Acetaminophen; Burns; Drug Overdose; Firesetting Behavior; Humans; Male; Middle Aged; Risk Factors; | 2012 |
Massive acetylcysteine overdose associated with cerebral edema and seizures.
Topics: Acetaminophen; Acetylcysteine; Adult; Brain Edema; Drug Overdose; Female; Humans; Medication Errors; | 2011 |
Trends in emergency department visits attributable to acetaminophen overdoses in the United States: 1993-2007.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Analgesics, Non-Narcotic; Child; Child, Prescho | 2011 |
Reliability of the reported ingested dose of acetaminophen for predicting the risk of toxicity in acetaminophen overdose patients.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cohort Studies; Dose-Response Relationship, Drug; Drug Over | 2012 |
Acetaminophen psi parameter: a useful tool to quantify hepatotoxicity risk in acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and | 2011 |
Clinical toxicology and drug regulation: a United Kingdom perspective.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipsychotic Agents; Antitussive Agents; Cyclooxygenase 2 | 2011 |
A dosing regimen for immediate N-acetylcysteine treatment for acute paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Antioxidants; Area Under | 2011 |
What can be done to reduce mortality from paracetamol overdoses? A patient interview study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Choice Behavior; Drug Labeling; Dr | 2012 |
Iron and acetaminophen a fatal combination?
Topics: Accidents; Acetaminophen; Adolescent; Adult; Biopsy; Brain; Diclofenac; Drug Overdose; Female; Human | 2011 |
Prescription-acquired acetaminophen use and potential overuse patterns: 2001-2008.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Analgesics, Non-Narcotic; Child; Child, Preschool; Cr | 2012 |
[Acute paracetamol overdose during pregnancy: a case report].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cesarean Section; Chemical and Drug Induced Liver In | 2011 |
Spell out 'acetaminophen' for patients' sake, group says.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Combinations; Drug Labeling; Drug Overdose; Drug Presc | 2011 |
Acetaminophen: hidden complexities of a simple overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Education, Continuing; Humans; United States | 2011 |
Dextromethorphan abuse in teens: beware acetaminophen poisoning!
Topics: Acetaminophen; Adolescent; Child; Dextromethorphan; Drug Overdose; Female; Humans; Illicit Drugs; Li | 2011 |
Opioid-paracetamol prescription patterns and liver dysfunction: a retrospective cohort study in a population served by a US health benefits organization.
Topics: Acetaminophen; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; Cohort Studies; Drug Comb | 2011 |
Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose.
Topics: Acetaminophen; Animals; Biocatalysis; Chemical and Drug Induced Liver Injury; CpG Islands; Disease M | 2011 |
[Paracetamol poisonings after the lifting of the place of sale restriction].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug and Narcotic C | 2011 |
Paracetamol overdose: the liver unit perspective.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2012 |
Ringer's lactate improves liver recovery in a murine model of acetaminophen toxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2011 |
Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cohort Studi | 2012 |
Problem-based review: paracetamol overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Diagnosis, Differential; Drug Overdose; Humans; Male | 2011 |
Delayed and prolonged elevated serum paracetamol level after an overdose - possible causes and implications.
Topics: Acetaminophen; Acetylcysteine; Adult; Drug Overdose; Humans; Liver Function Tests; Male; Nomograms; | 2011 |
Surrogate decision making: a woman in fulminant liver failure after an acetaminophen overdose.
Topics: Acetaminophen; Advance Care Planning; Analgesics, Non-Narcotic; Chronic Pain; Critical Care; Decisio | 2011 |
Trends in hepatic injury associated with unintentional overdose of paracetamol (Acetaminophen) in products with and without opioid: an analysis using the National Poison Data System of the American Association of Poison Control Centers, 2000-7.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; | 2012 |
The role of the glutathione S-transferase genes GSTT1, GSTM1, and GSTP1 in acetaminophen-poisoned patients.
Topics: Acetaminophen; Adult; Drug Overdose; Female; Gene Deletion; Genes; Genotype; Glutathione S-Transfera | 2012 |
Therapeutic hypothermia for treatment of intractable intracranial hypertension after liver transplantation.
Topics: Acetaminophen; Drug Overdose; Female; Humans; Hypothermia, Induced; Intracranial Hypertension; Intra | 2012 |
Comment on "Dental pain as a risk factor for accidental acetaminophen overdose: a case-control study".
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Male | 2012 |
Intravenous acetaminophen in the United States: iatrogenic dosing errors.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Drug Do | 2012 |
Complement activation in acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Complement Act | 2012 |
Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: early discrimination between survival and death.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical | 2012 |
Acetaminophen overdose in the Military Health System.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Analgesics, Non-Narcotic; Child; Child, Prescho | 2012 |
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.
Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Animals; Biomarkers; Caspase 3; Chemical and Drug | 2012 |
Suspected opioid overdose case resolved by CYP2D6 genotyping.
Topics: Acetaminophen; Adolescent; Analgesics, Opioid; Caffeine; Codeine; Cytochrome P-450 CYP2D6; Drug Comb | 2012 |
The sequential organ failure assessment (SOFA) score is an effective triage marker following staggered paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; APACHE; Chemical and Drug Induced Liver Injury; Drug | 2012 |
Paracetamol toxicity: What would be the implications of a change in UK treatment guidelines?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Coh | 2012 |
What are the factors associated with the length of hospital stay after acetaminophen overdose?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Length of Stay; Male | 2012 |
RE: Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema | 2013 |
Authors' response to Dr Reiter.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema | 2013 |
Six-year follow-up of impact of co-proxamol withdrawal in England and Wales on prescribing and deaths: time-series study.
Topics: Accidents; Acetaminophen; Analgesics; Cause of Death; Dextropropoxyphene; Drug Combinations; Drug Ov | 2012 |
Proposed MHRA changes to UK children's paracetamol dosing recommendations: modelling study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Weight; Child; Child, Preschool; Delivery of Health Ca | 2012 |
Risk of unintentional overdose with non-prescription acetaminophen products.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Confid | 2012 |
[Characterization of paracetamol overdose: report of a poison information center in Chile].
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Analgesics, Non-Narcotic; Child; Child, Preschool; Ch | 2012 |
Cheese: an old drug in a new wrapper.
Topics: Acetaminophen; Adolescent; Age Factors; Analgesics, Non-Narcotic; Animals; Data Interpretation, Stat | 2012 |
[Study on the effect using hemoperfusion to treat tylenol poisoned patients].
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Overdose; Drug-Related Side Effe | 2012 |
Overdosed prescription of paracetamol (acetaminophen) in a teaching hospital.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Databases, Factual; Drug Overdose; Drug Prescr | 2012 |
Paracetamol intoxications: a retrospective population-based study in Iceland.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Age Factors; Aged; Analgesics, Non-Narcotic; Chemic | 2012 |
Paracetamol (acetaminophen) overdose and acetylcysteine administration: should the United Kingdom adopt a single '150-line'?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2012 |
A survey of adult awareness and use of medicine containing acetaminophen.
Topics: Acetaminophen; Adult; Age Factors; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Awareness; Dr | 2013 |
Characteristics of older and younger patients with suspected paracetamol toxicity.
Topics: Acetaminophen; Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Overdose; Fem | 2012 |
Prevalence and correlates of exceeding the labeled maximum dose of acetaminophen among adults in a U.S.-based internet survey.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Drug Labeling; Drug Overdose; Female; Health Knowled | 2012 |
The Toxicology Investigators Consortium Case Registry--the 2011 experience.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid | 2012 |
Reported dose as a measure of drug exposure after paracetamol overdose in children.
Topics: Acetaminophen; Adolescent; Antidotes; Child; Child, Preschool; Dose-Response Relationship, Drug; Dru | 2013 |
Childhood self-poisoning: a one-year review.
Topics: Acetaminophen; Adolescent; Age Factors; Alcohol-Related Disorders; Chi-Square Distribution; Child; C | 2012 |
Elevated levels of the long pentraxin 3 in paracetamol-induced human acute liver injury.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Area Under Curve; Bacterial Infections; Biomar | 2013 |
Unintentional paediatric poisoning in rural Victoria: incidence and admission rates.
Topics: Accidents; Acetaminophen; Adolescent; Age Factors; Child; Child, Preschool; Drug Overdose; Emergency | 2012 |
Acetaminophen/diphenhydramine overdose in profound hypothermia.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2013 |
Going legal.
Topics: Acetaminophen; Adolescent; Drug Overdose; Emergency Medical Services; Female; Humans; Minors; Treatm | 2013 |
Pediatric emergency medicine: legal briefs.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aortic Aneurysm; Aortic Dissection; Appendicitis; | 2012 |
[Characterization of paracetamol overdose].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Male | 2012 |
Direct comparison of 20-hour IV, 36-hour oral, and 72-hour oral acetylcysteine for treatment of acute acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Aged, 8 | 2013 |
Approaches toward repeated supratherapeutic doses of paracetamol in children: a survey of medical directors of poison centres in North America and Europe.
Topics: Acetaminophen; Acetylcysteine; Child; Drug Overdose; Europe; Free Radical Scavengers; Health Care Su | 2002 |
Paracetamol recall: a natural experiment influencing analgesic poisoning.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Australia; Drug and Narcotic Control; Drug Overdose; Humans | 2002 |
Should a lower treatment line be used when treating paracetamol poisoning in patients with chronic alcoholism?: a case for.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Drug | 2002 |
The effect of regular medication on the outcome of paracetamol poisoning.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opi | 2002 |
Measuring plasma paracetamol concentrations in all patients with drug overdoses; development of a clinical decision rule and clinicians willingness to use it.
Topics: Acetaminophen; Adolescent; Adult; Aged; Child; Decision Support Techniques; Drug Overdose; Glasgow C | 2002 |
N-acetylcysteine overdosage after insignificant acetaminophen intake.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Drug Overdose; Expectorants; Fe | 2002 |
Unintentional overdose of analgesia secondary to acute dental pain.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, | 2002 |
[Without liver transplantation paracetamol intoxication is often be lethal, in spite of N-acetylcysteine therapy].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Humans; Liver Fai | 2002 |
United Kingdom legislation on pack sizes of analgesics: background, rationale, and effects on suicide and deliberate self-harm.
Topics: Acetaminophen; Analgesics; Drug Overdose; Drug Packaging; Humans; Suicide; Suicide Prevention; Unite | 2002 |
Toxicology. Protecting liver from painkiller's lethal dose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Androstanols; Animals; Benzoquinones; Constitutive Androsta | 2002 |
Effect of acetylcysteine on prothrombin index in paracetamol poisoning without hepatocellular injury.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Chemical and D | 2002 |
Paracetamol-related deaths in Scotland, 1994-2000.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Drug Packaging; Female; Humans; Male; Scotla | 2002 |
Brief safety updates: acetaminophen, ASA and kava.
Topics: Acetaminophen; Aspirin; Canada; Drug Overdose; Humans; Kava | 2002 |
[Other risks from drugs: the case of acetaminophen].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Drug-Related Side Effects and Adverse Reacti | 2002 |
Paracetamol: balancing risk against benefit.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Over | 2002 |
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Drug Overdose; Female; Hepatic Encephalopathy; | 2002 |
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Drug Overdose; Female; Hepatic Encephalopathy; | 2002 |
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Drug Overdose; Female; Hepatic Encephalopathy; | 2002 |
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Drug Overdose; Female; Hepatic Encephalopathy; | 2002 |
Summaries for patients. Acute liver failure in the United States.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Drug Overdose; Female; Hepatic Encephalopathy; | 2002 |
The effect of recalling paracetamol on hospital admissions for poisoning in Western Australia.
Topics: Accidents, Home; Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; A | 2003 |
Paracetamol poisoning and the international normalized ratio.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Coagulation; Drug Overdose; Factor VII Deficiency; Hu | 2003 |
[Paracetamol overdose and experimental cholestasis induced gene expression regulation that codified P-Glycoprotein type 1 in rats].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; ATP Binding Cassette Transporter, S | 2002 |
Changes in paracetamol, antidepressants and opioid poisoning in Scotland during the 1990s.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Analgesics, Non-Narcoti | 2003 |
Regular medication and paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Data Collection; Dr | 2003 |
Concomitant overdosing of other drugs in patients with paracetamol poisoning.
Topics: Acetaminophen; Alcoholism; Benzodiazepines; Drug Overdose; Humans; Risk Factors | 2003 |
Acetaminophen is main cause of acute liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Drug Therapy, Combination; Humans; Liver Fai | 2003 |
[Is systemic administration of N-acetylcysteine effective?].
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antidotes; D | 2003 |
Simultaneous determination of carisoprodol and acetaminophen in an attempted suicide by liquid chromatography-mass spectrometry with positive electrospray ionization.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Carisoprodol; Chromatography, Liquid; Drug Combinati | 2003 |
Liver death and regeneration in paracetamol toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Apoptosis; Cell Division; Drug Overdose; Hepatocytes; Human | 2003 |
Safe management of paracetamol overdose for all?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Clinical Competence; Drug Overdose; Emergency Service, Hosp | 2003 |
Accidental dextropropoxyphene poisoning.
Topics: Accidents, Home; Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Child, Preschool; Dext | 2003 |
Intravenous propacetamol overdose in a term newborn.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Female; Free Radical Scaveng | 2003 |
Warning note on a blood gas report leading to diagnosis of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Blood Glucose; Dextropropoxyphe | 2003 |
Co-proxamol and suicide: Licence needs to be changed.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Dextropropoxyphene; Drug Combinations; Drug Overdose; Human | 2003 |
Paracetamol poisoning--impact of pack size restrictions.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug | 2003 |
Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Diet; Drug Overdose; Enzyme | 2003 |
Successful treatment of acetaminophen overdose associated with hepatic failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Hu | 2003 |
Experience with albumin dialysis in five patients with severe overdoses of paracetamol.
Topics: Acetaminophen; Adult; Drug Overdose; Female; Hemodiafiltration; Humans; Male; Middle Aged; Serum Alb | 2003 |
Early death from paracetamol (acetaminophen) induced fulminant hepatic failure without cerebral oedema.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Edema; Cardiovascular Diseases; Cause of Death | 2003 |
Coingestion of cyclooxygenase inhibitors can worsen severe paracetamol poisoning by middle-sized and small arteries vasoconstriction.
Topics: Acetaminophen; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Angiography; Anti-Inflammatory | 2003 |
One-step immunoassay for acetaminophen and salicylate in serum, plasma, and whole blood.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Cross Reactions; Drug Overdose; Emergency Medical | 2003 |
Severe manifestations of coricidin intoxication.
Topics: Acetaminophen; Adolescent; Antidepressive Agents; Chemical and Drug Induced Liver Injury; Chlorpheni | 2003 |
[A rapid determination kit for acetaminophen].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Colorimetry; Drug Overdose; Humans; Male; Reagent Ki | 2003 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana | 2003 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana | 2003 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana | 2003 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana | 2003 |
Administering acetaminophen safely.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Interactions; Drug Overdose; Humans; Pain | 2003 |
Prothrombin time prolongation in paracetamol poisoning: a relevant marker of hepatic failure?
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Biomarkers; Drug Overdose; Endpoint Dete | 2003 |
Medical management of deliberate drug overdose: a neglected area for suicide prevention?
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Anxiety Ag | 2004 |
[Paracetamol poisoning in infants aged less than six months: dosage errors].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Infant; Medication Errors | 2004 |
The role of cytochrome-P450 inhibitors in the prevention of hepatotoxicity after paracetamol overdose in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome | 2004 |
Acetaminophen toxic level and N-acetylcysteine therapy: two patient reports.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Dose-Response Relationship, Dru | 2004 |
An unusual paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Critical Care; Drug Overdose; Humans; Hypernatremia; Male; | 2004 |
Acetaminophen dose accuracy and pediatric emergency care.
Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Analgesics, Non-Narcotic; Anti-Inflamma | 2004 |
Pharmaceutical drug overdose case reports. From the World Literature.
Topics: Acetaminophen; Adolescent; Adult; Aged; Amlodipine; Child, Preschool; Diphenhydramine; Dizocilpine M | 2003 |
Correlation of MCP1 with toxicity in acetaminophen overdose.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemokine CCL2; Cytokines | 2004 |
Reduced toxicity of acetaminophen in children: it's the liver.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Dose-Response Relation | 2004 |
Paracetamol overdose in suicidal attempt patients.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Male; Mid | 2004 |
Hyperamylasaemia and acute pancreatitis in paracetamol poisoning.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; | 2004 |
Comparison of patient questionnaires and plasma assays in intentional drug overdoses.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Drug Ov | 2004 |
Changes in pediatric toxic dose of acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans | 2004 |
Handle common pain reliever with care.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 1997 |
Renal transplants from non-heart beating paracetamol overdose donors.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Edema; Cryopreservation; Diuretics, Osmotic; D | 2004 |
Prospective evaluation of repeated supratherapeutic acetaminophen (paracetamol) ingestion.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Algorithms; Analges | 2004 |
Not enough relief from too much acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and Drug Induced Live | 2004 |
Status epilepticus after a massive intravenous N-acetylcysteine overdose leading to intracranial hypertension and death.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Child, Preschool; Drug Overdose; Fatal Outc | 2004 |
Gastrostomy use in attempted suicide.
Topics: Acetaminophen; Adolescent; Crohn Disease; Drug Overdose; Female; Gastrostomy; Humans; Risk Factors; | 2004 |
[Effect of N-acetylcysteine on prothrombin index in patients with uncomplicated paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Antidotes; Chemical and Drug Induced Liver I | 2004 |
Superactivated charcoal.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Charcoal; Drug Overdose; Humans; Time | 2004 |
[Liver albumin dialysis--application in acetaminophen poisoning].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Hepatic Encephalopathy; Human | 2004 |
Paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Charcoal; Child; Drug Ove | 2004 |
[Paracetamol poisoning in teenagers].
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Denmark; Drug Overdose; Female; Humans; | 2004 |
Acetaminophen overdose.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Drug Overdose; Emergencies; Female; Humans | 2005 |
Effect of paracetamol on uric acid determination.
Topics: Acetaminophen; Adult; Anticonvulsants; Autoanalysis; Bromides; Diazepam; Dose-Response Relationship, | 1975 |
The administration of N-acetylcysteine causes a decrease in prothrombin time in patients with paracetamol overdose but without evidence of liver impairment.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Blood Coagulation; Drug O | 2005 |
Prevalence of over-the-counter drug-related overdoses at Accident and Emergency departments in Northern Ireland--a retrospective evaluation.
Topics: Acetaminophen; Age Factors; Alcohol Drinking; Aspirin; Data Collection; Databases as Topic; Drug Com | 2005 |
Prolonged gastric emptying half-time and gastric hypomotility after drug overdose.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anticonvulsant | 2004 |
Commentary on: Severe manifestations of coricidin intoxication.
Topics: Acetaminophen; Chlorpheniramine; Dextromethorphan; Drug Combinations; Drug Overdose; Excitatory Amin | 2004 |
A multicentre study of coproxamol poisoning suicides based on coroners' records in England.
Topics: Acetaminophen; Adolescent; Adult; Aged; Autopsy; Child; Coroners and Medical Examiners; Dextropropox | 2005 |
Alpha-fetoprotein is a predictor of outcome in acetaminophen-induced liver injury.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; alpha-Fetoproteins; | 2005 |
'Opioid poisoning deaths in New Zealand (2001-2002)' and the UK's recent decision to withdraw the pain killer coproxamol.
Topics: Acetaminophen; Dextropropoxyphene; Drug and Narcotic Control; Drug Combinations; Drug Overdose; Huma | 2005 |
Experiences of a poison center network with renal insufficiency in acetaminophen overdose: an analysis of 17 cases.
Topics: Acetaminophen; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Analgesics, Non-Nar | 2005 |
Liver transplant and obstetrics.
Topics: Acetaminophen; Adult; Congenital Abnormalities; Drug Overdose; Female; Hepatolenticular Degeneration | 2004 |
MS 04-044: demographic features of drug and chemical poisoning in northern Malaysia.
Topics: Accidents; Acetaminophen; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Asian People; Dem | 2005 |
Age and paracetamol self-poisoning.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Age Factors; Aged; Aged, 80 and over; Alcoholism | 2005 |
Comment on "Acetaminophen: the 150 mg/kg myth".
Topics: Acetaminophen; Analgesics; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Overdose; | 2005 |
Effects of serum from patients with acute liver failure due to paracetamol overdose on human hepatocytes in vitro.
Topics: Acetaminophen; Cells, Cultured; Cytochrome P-450 Enzyme System; Drug Overdose; Female; Hepatocytes; | 2005 |
A new predictor of toxicity following acetaminophen overdose based on pretreatment exposure.
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Benzoquinones; Chemical and Drug Induced Liver | 2005 |
ECG abnormalities in co-proxamol (paracetamol/dextropropoxyphene) poisoning.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Dextropropoxyphene; Dru | 2005 |
Acute renal dysfunction in acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adult; Age Distribution; Aged; Drug Overdose; Em | 2005 |
Paracetamol + dextropropoxyphene: planned withdrawal from the British market.
Topics: Acetaminophen; Analgesics, Opioid; Dextropropoxyphene; Drug and Narcotic Control; Drug Overdose; Dru | 2005 |
A new acetaminophen nomogram with a different purpose.
Topics: Acetaminophen; Acetylcysteine; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced | 2005 |
A risk quantification instrument for acute acetaminophen overdose patients treated with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Alcohol Drinking; Analgesics, Non-N | 2005 |
Child safety. Caution about Children's Tylenol Meltaways.
Topics: Acetaminophen; Child; Child, Preschool; Drug Overdose; Drug Packaging; Humans; Medication Errors; Ta | 2005 |
Cytokines and toxicity in acetaminophen overdose.
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Chemokine CCL2; Child; | 2005 |
Co-proxamol overdose is associated with a 10-fold excess mortality compared with other paracetamol combination analgesics.
Topics: Acetaminophen; Analgesics, Opioid; Codeine; Drug Combinations; Drug Overdose; Humans; Proportional H | 2005 |
Acetaminophen toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema | 2005 |
[The influence of the dose, time since ingestion and concentration of the xenobiotic on the clinical state and severity of liver damage with patients intoxicated with paracetamol].
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Bilirubin; Biomarke | 2005 |
Paracetamol overdose and hepatotoxicity at a regional Australian hospital: a 4-year experience.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Alcohol Drinking; Austr | 2005 |
Estimates of acetaminophen (Paracetomal)-associated overdoses in the United States.
Topics: Acetaminophen; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Child; Databases, F | 2006 |
A potentially fatal prescribing error in the treatment of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Antidote | 2005 |
[Unfortunate packaging of paracetamol mixture].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Drug Overdose; Drug Packaging; Humans; Safety | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
A Cadillac ride to the emergency department.
Topics: Acetaminophen; Adolescent; Chlorpheniramine; Delirium; Dextromethorphan; Drug Combinations; Drug Ove | 2005 |
Paracetamol and salicylate testing: routinely required for all overdose patients?
Topics: Acetaminophen; Drug Overdose; Emergency Service, Hospital; Humans; Poisoning; Prospective Studies; S | 2006 |
Case studies in pediatric toxicology.
Topics: Acetaminophen; Antidotes; Antivenins; Charcoal; Child; Child, Preschool; Crotalid Venoms; Drug Overd | 2005 |
Efficacy of activated charcoal administered more than four hours after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Charcoal; Child; Drug Overdose; Female; Huma | 2006 |
Characteristics and outcomes of paracetamol poisoning cases at a general hospital in Northern Malaysia.
Topics: Acetaminophen; Adolescent; Adult; Aged; Child; Child, Preschool; Dose-Response Relationship, Drug; D | 2006 |
Acetadote (intravenous acetylcysteine): adverse effects more significant than with oral acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Antidotes; Drug Interactions; Drug Overdose; Em | 2006 |
Children's acetaminophen exposures reported to a regional poison control center.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Drug Overdose; Female; | 2006 |
Hepatoprotective studies on Hedyotis corymbosa (L.) Lam.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dose-Respo | 2006 |
Paracetamol induced hepatotoxicity.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Bilirubin; Blood Glucose; Chemical and Drug Ind | 2006 |
Acetaminophen sets records in the United States: number 1 analgesic and number 1 cause of acute liver failure.
Topics: Acetaminophen; Drug Overdose; Humans; Liver Failure, Acute; Prospective Studies; Suicide, Attempted; | 2006 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Liver Failure, Acute; Multicenter St | 2006 |
Potentially fatal paracetamol overdose and successful treatment with 3 days of intravenous N-acetylcysteine regime--a case report.
Topics: Acetaminophen; Acetylcysteine; Adult; Amylases; Antidotes; Codeine; Drug Overdose; Female; Humans; L | 2006 |
Time to make paracetamol with methionine available.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antidotes; Drug Combinations; Drug Overdose; Humans; Methio | 2006 |
Acetaminophen alert.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Labeling; Drug Overdose; Humans | 2006 |
"Unintentional" acetaminophen overdose on the rise: who is responsible? Dr Robert J Fontana is interviewed by Paul C Adams.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Global Health; Humans; Incidence; Liver Fail | 2006 |
Drug-related hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug | 2006 |
[Case report of repeated acetaminophen overdosing with various symptoms].
Topics: Abdominal Pain; Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Disseminated Intravasc | 2006 |
Unbalanced regulation of over-the-counter analgesics: the lesser of two evils?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Overdose; Hum | 2006 |
Acetaminophen: risk-management urgently required.
Topics: Accident Prevention; Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroida | 2006 |
New recommendation for N-acetylcystiene dosing may reduce incidence of adverse effects.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Body Weight; Drug Overdose; Huma | 2006 |
[Paracetamol poisoning--occurrence and treatment].
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Hu | 2006 |
Evaluation of renal enzymuria and cellular excretion as an marker of acute nephrotoxicity due to an overdose of paracetamol in Wistar rats.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Anim | 2006 |
Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid | 2006 |
Paracetamol availability and recent changes in paracetamol poisoning: is the 1998 legislation limiting availability of paracetamol being followed?
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; | 2006 |
[A patient who refused treatment after self-poisoning with paracetamol].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Male; Mental Health; | 2006 |
Adverse reaction from use of intravenous N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Anaphylaxis; Chemical and Drug Induced Liver Injury; Drug | 2006 |
[A patient who refused treatment after self-poisoning with paracetamol].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Mental Competency; Suicide, Attempte | 2006 |
Legislation restricting paracetamol sales and patterns of self-harm and death from paracetamol-containing preparations in Scotland.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Child; Drug Ove | 2006 |
Fulminant hepatic failure and paracetamol overuse with therapeutic intent in febrile children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Case-Control Studies; Child; Child, Preschool; Drug Overdos | 2006 |
Tylenol safety: is there reason to worry?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Drug Overdose; Humans; Liver | 2006 |
How has legislation restricting paracetamol pack size affected patterns of deprivation related inequalities in self-harm in Scotland?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Demography; Drug and Narcotic Control; Drug Overdose; Femal | 2007 |
[Post-marketing surveillance of acetylcysteine oral solution 17.6% "SENJU" for the antidote to acetaminophen overdose--use--results surveillance].
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Antidotes; Charcoal; Child; | 2006 |
Phenytoin-potentiated hepatotoxicity following acetaminophen overdose? A closer look.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anticonvulsants; Drug Overdose; Drug Synergism; Humans; Liv | 2007 |
Overdose risk prompts UK withdrawal of propoxyphene combination.
Topics: Acetaminophen; Dextropropoxyphene; Drug Combinations; Drug Overdose; Drug-Related Side Effects and A | 2006 |
Acetaminophen induces ER dependent signaling in mouse liver.
Topics: Acetaminophen; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Drug Ove | 2007 |
A prospective evaluation of shortened course oral N-acetylcysteine for the treatment of acute acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Analgesics, Non-Narcotic; Ca | 2007 |
Liver unit admission following paracetamol overdose with concentrations below current UK treatment thresholds.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose | 2007 |
Safety of recommended doses of paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 2007 |
Rhabdomyolysis and necrotic bowel after acetaminophen and ibuprofen overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Blood Chemical Analysis; Drug Overdose; Humans; Ibup | 2007 |
Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Antidepressive Agents; Aspirin; Causality; Death Certific | 2007 |
Does restricting pack size of paracetamol (acetaminophen) reduce suicides?
Topics: Acetaminophen; Adult; Antidepressive Agents; Aspirin; Automobiles; Carbon Monoxide Poisoning; Causal | 2007 |
Patient-tailored acetylcysteine administration.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Chemical and Drug Ind | 2007 |
Death from paracetamol overdose despite appropriate treatment with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Fatal Outcome; Free Radical | 2007 |
[The use of paracetamol in children--not just a drug but also a poison].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Infant | 2007 |
[Risk of acute hepatic insufficiency in children due to chronic accidental overdose of paracetamol (acetaminophen)].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Child, Preschool; Drug Overdose; Female; Fr | 2007 |
Dipyrone and acetaminophen: correct dosing by parents?
Topics: Acetaminophen; Adult; Age Distribution; Anti-Inflammatory Agents, Non-Steroidal; Brazil; Dipyrone; D | 2007 |
Self-harm in England: a tale of three cities. Multicentre study of self-harm.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Alcohol Drinking; Analgesics, Non-Narcotic; Anti | 2007 |
Self-harm in England: a tale of three cities. Multicentre study of self-harm.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Alcohol Drinking; Analgesics, Non-Narcotic; Anti | 2007 |
Self-harm in England: a tale of three cities. Multicentre study of self-harm.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Alcohol Drinking; Analgesics, Non-Narcotic; Anti | 2007 |
Self-harm in England: a tale of three cities. Multicentre study of self-harm.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Alcohol Drinking; Analgesics, Non-Narcotic; Anti | 2007 |
Self-harm in England: a tale of three cities. Multicentre study of self-harm.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Alcohol Drinking; Analgesics, Non-Narcotic; Anti | 2007 |
Self-harm in England: a tale of three cities. Multicentre study of self-harm.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Alcohol Drinking; Analgesics, Non-Narcotic; Anti | 2007 |
Self-harm in England: a tale of three cities. Multicentre study of self-harm.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Alcohol Drinking; Analgesics, Non-Narcotic; Anti | 2007 |
Self-harm in England: a tale of three cities. Multicentre study of self-harm.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Alcohol Drinking; Analgesics, Non-Narcotic; Anti | 2007 |
Self-harm in England: a tale of three cities. Multicentre study of self-harm.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Alcohol Drinking; Analgesics, Non-Narcotic; Anti | 2007 |
Helping patients and families avoid inadvertent acetaminophen overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Drug Synergism; Emergency Nursing; Humans; M | 2007 |
[A study of 355 consecutive acute poisoning cases admitted to an emergency ward at Copenhagen University Hospital, Bispebjerg in 2001].
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Alcoholic Intoxication; Analgesics, Non-Narco | 2007 |
Acute fatal acetaminophen overdose without liver necrosis.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Drug Overdose; Fatal Outcome; Female; Fo | 2007 |
Weight-based N-acetylcysteine dosing chart to minimise the risk of calculation errors in prescribing and preparing N-acetylcysteine infusions for adults presenting with paracetamol overdose in the emergency department.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Clinical Competence; Drug Administra | 2007 |
Hypokalaemia following paracetamol overdose in two teenage girls.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; | 2007 |
Effect of acute paracetamol overdose on changes in serum and urine electrolytes.
Topics: Acetaminophen; Adolescent; Adult; Drug Overdose; Electrolytes; Female; Humans; Male; Middle Aged; Pr | 2007 |
Hospitalizations for acetaminophen overdose: a Canadian population-based study from 1995 to 2004.
Topics: Accidents; Acetaminophen; Adolescent; Adult; Age Distribution; Aged; Alberta; Analgesics, Non-Narcot | 2007 |
Emergency department visits for acetaminophen overdose: a Canadian population-based epidemiologic study (1997-2002).
Topics: Accidents; Acetaminophen; Adolescent; Adult; Age Distribution; Aged; Alberta; Analgesics, Non-Narcot | 2007 |
Induction of hepatobiliary efflux transporters in acetaminophen-induced acute liver failure cases.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; ATP-Binding Cassette Transporters; | 2007 |
Paracetamol overdose as a result of dental pain requiring medical treatment - two case reports.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Antidotes; Chemical and Drug Ind | 2007 |
Death of a living liver donor from illicit drugs.
Topics: Acetaminophen; Adult; Child, Preschool; Drug Overdose; Ethics, Medical; Fatal Outcome; Female; Human | 2007 |
Impact of activated charcoal after acute acetaminophen overdoses treated with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Indu | 2007 |
Safety and efficacy of intravenous N-acetylcysteine for acetaminophen overdose: analysis of the Hunter Area Toxicology Service (HATS) database.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Child; Child, Preschool; Database Management Syste | 2007 |
Acetaminophen overdose and N-acetylcysteine therapy.
Topics: Acetaminophen; Acetylcysteine; Brunei; Drug Overdose; Humans | 2007 |
Clinical excellence exemplar.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2007 |
Morphine in breast milk.
Topics: Acetaminophen; Analgesics; Breast Feeding; Codeine; Drug Overdose; Fatal Outcome; Female; Humans; In | 2007 |
Paracetamol (acetaminophen) pack size restrictions and poisoning severity: time trends in enquiries to a UK poisons centre.
Topics: Acetaminophen; Age Distribution; Analgesics, Non-Narcotic; Drug Overdose; Drug Packaging; Female; Hu | 2007 |
Validation of ICD-9-CM/ICD-10 coding algorithms for the identification of patients with acetaminophen overdose and hepatotoxicity using administrative data.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Alberta; Algorithms | 2007 |
[Clinical value of estimated half-life in paracetamol poisoning as a complement to Rumack's nomogram].
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Half-Life; Huma | 2007 |
Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy.
Topics: Acetaminophen; Adolescent; Algorithms; Chlorpheniramine; Dextromethorphan; Drug Combinations; Drug O | 2007 |
The effect of yogurt on acetaminophen absorption by activated charcoal and burnt toast.
Topics: Absorption; Acetaminophen; Bread; Charcoal; Drug Overdose; Gastrointestinal Contents; Humans; Intest | 2007 |
Acute acetaminophen overdose is associated with dose-dependent hypokalaemia: a prospective study of 331 patients.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Dose-Response Relationshi | 2008 |
Comparison of S-adenosyl-L-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Aldehydes; Analysis of Variance; Animals; Blott | 2008 |
Does the patient history predict hepatotoxicity after acute paracetamol overdose?
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Aspartate Amino | 2008 |
Co-proxamol: where have all the patients gone?
Topics: Acetaminophen; Aged; Analgesics; Arthritis, Rheumatoid; Dextropropoxyphene; Dose-Response Relationsh | 2008 |
Acute ethanol coingestion confers a lower risk of hepatotoxicity after deliberate acetaminophen overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Etha | 2008 |
Hypokalaemia following paracetamol overdose.
Topics: Acetaminophen; Animals; Drug Overdose; Humans; Hypokalemia | 2008 |
False positive acetaminophen concentrations in patients with liver injury.
Topics: Acetaminophen; Aged; Bilirubin; Drug Overdose; False Positive Reactions; Female; Humans; Hyperbiliru | 2008 |
Survey of cases of paracetamol overdose in the UK referred to National Poisons Information Service (NPIS) consultants.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Databases, Factual; Drug Overdose; Humans; Poison Control C | 2008 |
Prolonged absorption and delayed peak paracetamol concentration following poisoning with extended-release formulation.
Topics: Absorption; Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Delayed-Action Prepara | 2008 |
A depressed adolescent at high risk of suicidal behavior.
Topics: Acetaminophen; Adolescent; Antidepressive Agents; Cognitive Behavioral Therapy; Combined Modality Th | 2008 |
Stability of a flavored formulation of acetylcysteine for oral administration.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Antidotes; Chromatography, High Pressure Liquid | 2008 |
Serum urea concentration and the risk of hepatotoxicity after paracetamol overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Biomarkers; Blood Glucose; Chemical and Drug Induced | 2008 |
Analgesics.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 2008 |
Estimated risk of hepatotoxicity after an acute acetaminophen overdose in alcoholics.
Topics: Acetaminophen; Acetylcysteine; Alcoholism; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induc | 2008 |
Key features of the patient-tailored N-acetylcysteine protocol.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Analgesics, Non-Narcotic; Ca | 2008 |
Inpatient admissions for drug-induced liver injury: results from a single center.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Chemical and Drug Induced Live | 2008 |
Neuroleptic malignant syndrome induced by quetiapine overdose.
Topics: Acetaminophen; Antidotes; Antipsychotic Agents; Dibenzothiazepines; Drug Overdose; Female; Humans; L | 2008 |
Comment on "Acute ethanol coingestion confers a lower risk of hepatotoxicity after deliberate acetaminophen overdose".
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2008 |
Frequency of medication errors with intravenous acetylcysteine for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Child; | 2008 |
Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2008 |
Impact of liver disease, alcohol abuse, and unintentional ingestions on the outcomes of acetaminophen overdose.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholism; Child; Child, Preschool; Drug | 2008 |
Co-proxamol withdrawal has reduced suicide from drugs in Scotland.
Topics: Acetaminophen; Adult; Analgesics; Dextropropoxyphene; Drug Combinations; Drug Overdose; Female; Huma | 2008 |
Management of paracetamol poisoning.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Charcoal; Drug Overdose; Humans; Intestinal Absorption; Tim | 1995 |
Management of paracetamol poisoning.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Charcoal; Drug Interactions; Drug Overdose; Humans; Intesti | 1995 |
Management of paracetamol poisoning.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Emergency Medical Services; Humans | 1995 |
Management of paracetamol poisoning.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans | 1995 |
More on extended-release acetaminophen.
Topics: Absorption; Acetaminophen; Adolescent; Delayed-Action Preparations; Drug Overdose; Female; Humans | 1995 |
A 7-year experience of severe acetaminophen-induced hepatotoxicity (1987-1993).
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Brain Edema; Chi-S | 1995 |
Hepatotoxicity associated with acetaminophen usage in patients receiving multiple drug therapy for tuberculosis.
Topics: Acetaminophen; Adult; Capreomycin; Ciprofloxacin; Drug Combinations; Drug Overdose; Ethambutol; Fema | 1994 |
The management of paracetamol overdose by junior doctors.
Topics: Acetaminophen; Acetylcysteine; Documentation; Drug Overdose; Health Knowledge, Attitudes, Practice; | 1995 |
[Development of biochemical and histopathological parameters in paracetamol overdose in experimental cholestasis].
Topics: Acetaminophen; Acute Disease; Animals; Cholestasis, Extrahepatic; Drug Overdose; Glucuronosyltransfe | 1995 |
Acetaminophen poisoning and liver function.
Topics: Acetaminophen; Acetylcysteine; Adult; Drug Overdose; Female; Humans; Liver | 1994 |
[Hemorrhagic pancreatitis. A rare complication of paracetamol poisoning].
Topics: Acetaminophen; Drug Overdose; Fatal Outcome; Female; Hemorrhage; Humans; Middle Aged; Pancreatitis; | 1995 |
[A case of paracetamol retard poisoning with fatal outcome].
Topics: Acetaminophen; Adult; Delayed-Action Preparations; Drug Overdose; Fatal Outcome; Female; Humans; Liv | 1995 |
Cimetidine as adjunctive treatment for acetaminophen overdose.
Topics: Acetaminophen; Adult; Cimetidine; Drug Overdose; Female; Humans; Liver Diseases; Male | 1995 |
Abuse of paracetamol in childhood fever.
Topics: Acetaminophen; Child; Drug Overdose; Humans | 1995 |
Overdose of extended-release acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Delayed-Action Preparations; Drug Overdose; Female; Half- | 1995 |
Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Drug Overdose; Humans | 1995 |
Studies on paracetamol binding to serum proteins.
Topics: Acetaminophen; Adolescent; Adult; Blood Proteins; Drug Overdose; Female; Humans; Male; Protein Bindi | 1994 |
Why patients choose paracetamol for self poisoning and their knowledge of its dangers.
Topics: Acetaminophen; Adolescent; Adult; Aged; Attitude to Health; Awareness; Choice Behavior; Drug Overdos | 1995 |
Paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Benzoquinones; Chemical and Drug Induced Liver Injury; Clinical Proto | 1993 |
Subtleties of managing acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Child, Preschool; Drug Overdose; Humans; Infant; Ipecac; Po | 1994 |
Delayed toxic acetaminophen level after initial four hour nontoxic level.
Topics: Acetaminophen; Acetylcysteine; Adult; Dextropropoxyphene; Drug Overdose; Female; Humans; Naproxen; T | 1994 |
Acetaminophen ingestion in childhood--cost and relative risk of alternative referral strategies.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child, Preschool; Cost-Benefit Analysis; Drug | 1994 |
Acetaminophen poisoning and liver function.
Topics: Acetaminophen; Alcoholism; Animals; Drug Overdose; Humans; Liver | 1994 |
Acetaminophen poisoning and liver function.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Humans | 1994 |
Retinol binding proteinuria and phosphaturia: markers of paracetamol-induced nephrotoxicity.
Topics: Acetaminophen; Adult; Biomarkers; Creatinine; Drug Overdose; Female; Fluorescence Polarization; Huma | 1994 |
Association of acetaminophen hepatotoxicity with fasting and ethanol use.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcohol Drinking; Alcoholism; Chemical and Drug Induced Live | 1994 |
Baseline liver function tests following acetaminophen ingestion. What is the utility?
Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Li | 1994 |
Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury.
Topics: Acetaminophen; Biopsy; Cell Count; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hu | 1994 |
Parental and medical over-administration of acetaminophen causing lethal hepatotoxicity in a 10-year-old.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Fatal Outcome; Female; | 1994 |
Extent of the acute phase response in fulminant hepatic failure.
Topics: Acetaminophen; Acute-Phase Reaction; Adolescent; Adult; alpha 1-Antitrypsin; Bacterial Infections; C | 1994 |
Deaths from substance overdose in the Lothian and Borders region of Scotland (1983-1991).
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Dextropropoxyphene; Drug Ove | 1994 |
A prospective evaluation of the effect of activated charcoal before oral N-acetylcysteine in acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Charcoal; | 1994 |
Severe hepatotoxicity, acute renal failure, and pancytopenia in a young child after repeated acetaminophen overdosing.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Child, P | 1994 |
Serum sickness-like illness associated with N-acetylcysteine therapy.
Topics: Acetaminophen; Acetylcysteine; Adult; Drug Overdose; Humans; Male; Serum Sickness | 1994 |
Cerebral blood flow and metabolism in fulminant liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Blood Flow Velocity; Brain; Brain Edema; Drug Overdose; Epopro | 1994 |
Ondansetron for treating nausea and vomiting in the poisoned patient.
Topics: Acetaminophen; Adolescent; Charcoal; Colchicine; Drug Overdose; Female; Humans; Nausea; Ondansetron; | 1994 |
Acetaminophen treatment nomogram.
Topics: Acetaminophen; Acetylcysteine; Adult; Drug Overdose; Female; Hepatic Encephalopathy; Humans; Referen | 1994 |
Chronic paracetamol poisoning in children: a warning to health professionals.
Topics: Acetaminophen; Blood Coagulation Disorders; Chronic Disease; Diarrhea; Drug Overdose; Health Occupat | 1994 |
Misoprostol protection against acetaminophen-induced hepatotoxicity in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Disease Models, Animal; Drug Overdose; Liver; Male; Mi | 1994 |
Higher risk groups and paracetamol overdose.
Topics: Acetaminophen; Drug Overdose; Female; Humans; Male; Risk Factors | 1993 |
Paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Drug Overdose; Gastric Lavage; Humans; Liver | 1993 |
Paracetamol poisoning and hepatotoxicity in Chinese--the Prince of Wales Hospital (Hong Kong) experience.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Chi | 1993 |
The fatal paracetamol dosage--how low can you go?
Topics: Acetaminophen; Adolescent; Cause of Death; Chemical and Drug Induced Liver Injury; Dose-Response Rel | 1993 |
Prediction of acetaminophen concentrations in overdose patients using a Bayesian pharmacokinetic model.
Topics: Acetaminophen; Adolescent; Adult; Bayes Theorem; Child; Drug Overdose; Female; Humans; Male; Models, | 1994 |
[A fatal case due to intoxication with seven drugs detected by GC-MS and TDx methods].
Topics: Acetaminophen; Adult; Bromisovalum; Caffeine; Drug Overdose; Female; Fluorescent Antibody Technique; | 1993 |
Drug analysis in fly larvae.
Topics: Acetaminophen; Amitriptyline; Animals; Dextropropoxyphene; Diptera; Drug Combinations; Drug Overdose | 1993 |
Liver failure induced by paracetamol.
Topics: Acetaminophen; Cause of Death; Drug Overdose; Humans; Poisoning; Suicide | 1993 |
Liver failure induced by paracetamol.
Topics: Acetaminophen; Adolescent; Drug Overdose; Humans; Liver Failure; Suicide, Attempted | 1993 |
Liver failure induced by paracetamol.
Topics: Acetaminophen; Drug Overdose; Humans; Liver Failure; Suicide, Attempted | 1993 |
Kidney donation after paracetamol overdose.
Topics: Acetaminophen; Adolescent; Adult; Drug Overdose; Female; Humans; Kidney; Middle Aged; Tissue Donors | 1993 |
The fatal paracetamol dosage--how low can you go?
Topics: Acetaminophen; Adolescent; Cause of Death; Dose-Response Relationship, Drug; Drug Overdose; Female; | 1993 |
Cesarean section after maternal acetaminophen overdose.
Topics: Acetaminophen; Adult; Anesthesia, General; Anesthesia, Obstetrical; Cesarean Section; Drug Overdose; | 1993 |
Gilbert's disease: a risk factor for paracetamol overdosage?
Topics: Acetaminophen; Biotransformation; Drug Overdose; Gilbert Disease; Humans; Risk Factors | 1993 |
Pericoronitis and accidental paracetamol overdose: a cautionary tale.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Cystine; Dextropropoxyphene; Drug Combinations; Drug Over | 1993 |
Liver failure induced by paracetamol.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Humans; Liver Failure, Acute | 1993 |
Paracetamol cardiotoxicity.
Topics: Acetaminophen; Adult; Arrhythmia, Sinus; Drug Overdose; Electrocardiography; Humans; Male | 1993 |
Liver failure induced by paracetamol.
Topics: Acetaminophen; Adult; Drug Overdose; Female; Hepatic Encephalopathy; Humans; Hypothermia | 1993 |
International update: alternative treatment for common but dangerous acetaminophen overdoses.
Topics: Acetaminophen; Cystine; Drug Overdose; Emergency Nursing; Humans | 1993 |
Liver failure induced by paracetamol.
Topics: Acetaminophen; Drug Overdose; Drug Packaging; Humans | 1993 |
Organ donation after paracetamol overdose.
Topics: Acetaminophen; Adult; Brain Death; Cerebral Angiography; Drug Overdose; Humans; Male; Tissue Donors | 1993 |
Parents beware of accidental overdose of acetaminophen.
Topics: Acetaminophen; Child; Drug Overdose; Health Education; Humans | 1995 |
The Danish liver transplantation program and patients with serious acetaminophen intoxication.
Topics: Acetaminophen; Adolescent; Adult; Aged; Child; Denmark; Drug Overdose; Female; Hepatic Encephalopath | 1995 |
Adenosine triphosphate (ATP) levels in paracetamol-induced cell injury in the rat in vivo and in vitro.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Dose | 1995 |
Extended-release acetaminophen overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Delayed-Action Preparations; Drug Overdose; Humans | 1996 |
New ways of looking at an old molecule.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Electrocardiography; Heart; Heart Diseases; | 1996 |
Changes in the pattern of deliberate self-poisoning presenting at Craigavon Area Hospital: 1976, 1986 and 1991.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Benzodiazepines; Child; Drug Overdose; F | 1994 |
Paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cystine; Drug Labeling; Drug Overdose; Humans | 1996 |
Evidence for potential application of zinc as an antidote to acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Chemical and Drug Induced L | 1995 |
[Poisonings with analgesics. Paracetamol and dextropropoxyphene dominate and cause the most severe symptoms in a 3-year material].
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Dextropropoxyphene; | 1996 |
Coagulation factor V levels as a prognostic indicator in fulminant hepatic failure.
Topics: Acetaminophen; Adolescent; Adult; Case-Control Studies; Drug Overdose; Factor V; Hepatic Encephalopa | 1996 |
Acetaminophen overdose: need to consider intravenous preparation of N-acetylcysteine in the United States.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Child; Drug O | 1996 |
Cholestasis as a liver protective factor in paracetamol acute overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cholestasi | 1995 |
Paracetamol overdose.
Topics: Acetaminophen; Drug Overdose; Drug Packaging; England; Humans; Suicide Prevention | 1996 |
Treating paracetamol overdose by charcoal haemoperfusion and long-hours high-flux dialysis.
Topics: Acetaminophen; Adolescent; Adult; Alcohol Drinking; Charcoal; Combined Modality Therapy; Drug Overdo | 1996 |
Acetaminophen and salicylate serum levels in patients with suicidal ingestion or altered mental status.
Topics: Acetaminophen; Acid-Base Equilibrium; Adult; Aged; Analgesics, Non-Narcotic; Cognition Disorders; Dr | 1996 |
Hospitalisation for deliberate self-poisoning in Scotland from 1981 to 1993: trends in rates and types of drugs used.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Cross-Sectional Studies; Drug Overdose; Female; Hum | 1996 |
Media influence on parasuicide. A study of the effects of a television drama portrayal of paracetamol self-poisoning.
Topics: Acetaminophen; Adolescent; Adult; Child; Drug Overdose; Female; Humans; Linear Models; Logistic Mode | 1995 |
Paracetamol overdose.
Topics: Acetaminophen; Drug Overdose; Gastric Lavage; Humans; Poisoning | 1996 |
The acetaminophen nomogram: will it withstand the test of the extended relief formulation?
Topics: Acetaminophen; Acetylcysteine; Delayed-Action Preparations; Drug Overdose; Humans; Reference Values | 1996 |
Safety packaging of acetaminophen combination preparations and severity of adult poisoning.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Drug Overdose; Drug Packaging; Female; Hu | 1996 |
Use of the Rumack-Matthew nomogram in cases of extended-release acetaminophen toxicity.
Topics: Acetaminophen; Adolescent; Delayed-Action Preparations; Drug Overdose; Female; Humans | 1996 |
Reducing paracetamol overdoses.
Topics: Acetaminophen; Drug Labeling; Drug Overdose; Health Education; Humans; United Kingdom | 1996 |
Should a patient who attempted suicide receive a liver transplant?
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Drug Overdose; Ethicists; | 1996 |
Self-poisoning and the general hospital.
Topics: Acetaminophen; Adolescent; Adult; Drug Overdose; England; Female; Hospitals, General; Humans; Male; | 1996 |
Changing patterns of self-poisoning in a UK health district.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents; Drug Overdose; Eth | 1996 |
Pediatric subacute acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chi | 1997 |
Outcome of acetaminophen overdose in pediatric patients and factors contributing to hepatotoxicity.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; California; Chemical and Drug Induced Liver Inj | 1997 |
Transplantation in patients with paracetamol-induced fulminant hepatic failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Hepatic Encephalopathy; Humans; Liver Transp | 1997 |
Acute psychosis associated with acetaminophen overdose.
Topics: Acetaminophen; Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; HIV Sero | 1997 |
Adverse reactions to N-acetylcysteine in Inuit to paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Greenland; Hu | 1996 |
Reducing paracetamol overdoses. Provide hurdles to overdosing.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Health Education; Humans | 1997 |
Reducing paracetamol overdoses. Methionine should be included in all paracetamol preparations.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antidotes; Drug Compounding; Drug Overdose; Humans; Methion | 1997 |
Reducing paracetamol overdoses. Paracetamol is wrongly blamed.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cause of Death; Drug Overdose; Humans | 1997 |
Reducing paracetamol overdoses. Proposals will have negative effects.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Legislation, Drug | 1997 |
Pneumatosis intestinalis.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Colon; Drug Overdose; Female; Humans; Pneumatosis Cy | 1997 |
Use of paracetamol for suicide and non-fatal poisoning in the UK and France: are restrictions on availability justified?
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Drug Overdose; France; Humans; Mid | 1997 |
Tylenol Extended Relief overdose.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Half-Life; Humans | 1997 |
[Anaphylactic reaction to N-acetylcysteine after poisoning with paracetamol].
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Drug Overdos | 1997 |
Public should know of efficacy of early hospital treatment of paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Health Education; Hospitalization; Humans; M | 1997 |
Should methionine be added to every paracetamol tablet?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Res | 1997 |
Placental transfer of N-acetylcysteine following human maternal acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Biological Transport; Chromatography, High | 1997 |
Ibuprofen and/or acetaminophen: what price for "euthermia"?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmac | 1997 |
Site-to-site variability of drug concentrations in skeletal muscle.
Topics: Acetaminophen; Central Nervous System Agents; Dibenzocycloheptenes; Dothiepin; Drug Overdose; Gas Ch | 1997 |
Dissolution of acetaminophen tablets under overdose conditions.
Topics: Acetaminophen; Delayed-Action Preparations; Drug Overdose; Solubility; Tablets | 1997 |
Paracetamol poisoning.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antidotes; Drug Administration Schedule; Drug Overdose; Hum | 1997 |
Adolescents' misperceptions of the dangerousness of acetaminophen in overdose.
Topics: Acetaminophen; Adolescent; Adolescent Behavior; Analgesics, Non-Narcotic; Attitude to Health; Drug O | 1997 |
John Holland: the near-death of a frightened sailor: specific phobia and suicide-related behavior.
Topics: Acetaminophen; Adolescent; Adult; Drug Overdose; Female; Humans; Male; Middle Aged; Phobic Disorders | 1997 |
Comparison of two assays for measuring plasma concentrations of paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Monitoring; Drug Overdose; Humans; Sensitivity and Spe | 1997 |
[A trend among young people: to overdose on paracetamol].
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Drug Overdose; Female; Humans; Male; Sub | 1997 |
Oral N-acetylcysteine given intravenously for acetaminophen overdose: we shouldn't have to, but we must.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Free Radical Scavengers; Hum | 1998 |
Intravenous administration of oral N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Case-Control Studi | 1998 |
The risk factors of death from the acetaminophen poisoning with antipyretic-analgesic drugs in Japan.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Disseminated In | 1997 |
Drug concentration in selected skeletal muscles.
Topics: Acetaminophen; Adult; Aged; Amitriptyline; Analgesics; Analgesics, Opioid; Anti-Anxiety Agents; Anti | 1998 |
Acetaminophen overdose with therapeutic intent.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chi | 1998 |
Acetaminophen toxicity in an urban county hospital.
Topics: Acetaminophen; Aged; Drug Overdose; Hospitalization; Humans; Patient Selection; Suicide, Attempted | 1998 |
Acetaminophen toxicity in an urban county hospital.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Dise | 1998 |
Acetaminophen toxicity in an urban county hospital.
Topics: Acetaminophen; Alcoholism; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug | 1998 |
Adding methionine to every paracetamol tablet. Paracetamol overdose is so rare in India that adding methionine would be wrong.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Child; Child, Preschool; Drug Combinations; Drug Ove | 1998 |
Adding methionine to every paracetamol tablet. Drugs as important as paracetamol in developing countries should not be tainted.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Developing Countries; Drug Combinations; Drug Overdose; Hum | 1998 |
Adding methionine to every paracetamol tablet. Plan is needed for way in which paracetamol and other analgesics are sold.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Combinations; Drug Industry; Drug Overdose; Health Pla | 1998 |
Paracetamol in suicide and non-accidental overdose--are restrictions justified?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Legislation, Drug; Suicide Preventio | 1997 |
Overdose among youth in Bahrain: psycho-social characteristics, contact with helping agencies and problems.
Topics: Acetaminophen; Adjustment Disorders; Adolescent; Adult; Analgesics, Non-Narcotic; Attitude to Health | 1997 |
Emergency! Acetaminophen overdose.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anorexia Nervosa; Chemical and Drug Induced Liv | 1998 |
More on interference of N-acetylcysteine in measurement of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; False Nega | 1998 |
Toxic levels of acetaminophen produce a major positive interference on Glucometer Elite and Accu-chek Advantage glucose meters.
Topics: Acetaminophen; Blood Chemical Analysis; Blood Glucose; Drug Overdose; Electrochemistry; Emergency Se | 1998 |
Ethanol-acetaminophen cocktail: the debate continues!
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Retrospect | 1998 |
The effects of glutathione glycoside in acetaminophen-induced liver cell necrosis.
Topics: Acetaminophen; Animals; Drug Overdose; Glutathione; Glycosides; Humans; Lipid Peroxidation; Liver; M | 1998 |
Outcome of acetaminophen overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child, Preschool; Drug Overdose; Humans; Poison Control Cen | 1998 |
Massive sulfasalazine and paracetamol ingestion causing acidosis, hyperglycemia, coagulopathy, and methemoglobinemia.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Acute Disease; Adult; Anti-Inflammatory Agents; Blo | 1998 |
Role of cimetidine in the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Overdose; Humans; L | 1998 |
Drugs detected in patients suspected of acute intoxication.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholic Intoxication; Am | 1997 |
Deaths from low dose paracetamol poisoning. Executive action is needed to change national guidelines.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Death, Sudden; Drug Overdose; Humans; Practice Guidelines a | 1998 |
Fulminant hepatic failure from acetaminophen in an anorexic patient treated with carbamazepine.
Topics: Acetaminophen; Adolescent; Anorexia Nervosa; Carbamazepine; Drug Overdose; Drug Synergism; Drug Ther | 1998 |
Etiology and outcome for 295 patients with acute liver failure in the United States.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Drug Overdose; Hepatic Encephalopathy; Humans; Liver | 1999 |
Late-presenting acute acetaminophen toxicity and the role of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical a | 1998 |
An IgM paraprotein causing a falsely low result in an enzymatic assay for acetaminophen.
Topics: Acetaminophen; Aged; Drug Overdose; False Negative Reactions; Humans; Immunoglobulin M; Male; Parapr | 1999 |
Limitation of over the counter sales of paracetamol. Restriction of 16g will not prevent overdose and is unhelpful for patients with chronic disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chronic Disease; Drug Overdose; Humans; Nonprescription Dru | 1998 |
Effects of a drug overdose in a television drama on presentations to hospital for self poisoning: time series and questionnaire study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Child; Confiden | 1999 |
Effects of a drug overdose in a television drama on knowledge of specific dangers of self poisoning: population based surveys.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Awareness; Drama; Drug Overdose; Female; Health Surveys; Hu | 1999 |
Delayed increase in acetaminophen concentration after Tylenol PM overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Diphenhydramine; Drug Overdose; Female; Gastric Empt | 1999 |
Renal impairment without hepatic damage after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adolescent; Charcoal; Drug Overdose; Female; Hum | 1999 |
Characteristics and risk factors of acetaminophen-induced hepatitis in Taiwan.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdos | 1999 |
Hypothyroidism protects rat liver from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Chemical and Drug Induced Li | 1999 |
"Late presenters" after paracetamol self poisoning.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Child; Child, Preschool; Drug Over | 1998 |
Brief report. The overdose process-adolescents' experience of taking an overdose and their contact with services.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Drug Overdose; England; Female; Humans; | 1999 |
Suicidal paracetamol poisoning of a pregnant woman just before a delivery.
Topics: Acetaminophen; Adult; Aspartate Aminotransferases; Drug Overdose; Female; Humans; Infant, Newborn; I | 1999 |
Prediction of hepatic encephalopathy in paracetamol overdose: a prospective and validated study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Child; Drug Overdose; Female; Hepa | 1999 |
Paracetamol overdose in a liver transplantation centre: an 8-year experience.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Liver; Li | 1999 |
Acetaminophen overdose? A quick answer.
Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Antidotes; Charcoal; Child; Drug Compounding; | 1999 |
Predicting concentrations in children presenting with acetaminophen overdose.
Topics: Acetaminophen; Adult; Age Factors; Analgesics, Non-Narcotic; Antidotes; Body Weight; Charcoal; Child | 1999 |
Potential danger from too much acetaminophen in opiate agonist combination products.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Analgesics, Non-Narcoti | 1999 |
An unusual case of acetaminophen overdose.
Topics: Absorption; Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Diphenhydramine; Drug Combinations; | 1999 |
Population-based incidence and outcome of acetaminophen poisoning by type of ingestion.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Confidence Intervals; Drug Overdose; Emergency | 1999 |
Metabolic acidosis and coma following a severe acetaminophen overdose.
Topics: Acetaminophen; Acidosis; Adult; Coma; Drug Overdose; Female; Humans | 1999 |
Fulminant liver failure in a young child following repeated acetaminophen overdosing.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cause of Death; Child, Preschool; Drug Overdose; Female; Hu | 1999 |
Activated charcoal reduces the need for N-acetylcysteine treatment after acetaminophen (paracetamol) overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Charcoal; Drug Overdose; | 1999 |
Predictive properties of a qualitative urine acetaminophen screen in patients with self-poisoning.
Topics: Acetaminophen; Adolescent; Adult; Aged; Drug Overdose; False Positive Reactions; Female; Humans; Mal | 1999 |
Accidental paracetamol overdosing and fulminant hepatic failure in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Drug Overdose; Humans; Infant; Liv | 1999 |
Hemodialysis as adjunctive therapy for severe acetaminophen poisoning: a case report.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Renal Dialysis | 1999 |
Alcohol-acetaminophen syndrome. Even moderate social drinkers are at risk.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Drug Interactions; Drug Overdose; Ethanol | 2000 |
A very long trip to gastric decontamination!
Topics: Acetaminophen; Charcoal; Drug Overdose; Emetics; Gastric Lavage; Humans; Ipecac; Time Factors | 2000 |
Arthrogryposis multiplex congenita and bilateral mid-brain infarction following maternal overdose of co-proxamol.
Topics: Acetaminophen; Arthrogryposis; Brain; Brain Damage, Chronic; Cocaine-Related Disorders; Dextropropox | 1997 |
Shorter duration of oral N-acetylcysteine therapy for acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Age Distribution; Aged; Anal | 2000 |
Pediatric acetaminophen overdose: risk factors associated with hepatocellular injury.
Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Ove | 2000 |
The hepatic inflammatory response after acetaminophen overdose: role of neutrophils.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; CD18 Antigens; Chemokines, CXC; Drug Overdose; Flo | 2000 |
Paracetamol poisoning--the emerging threat.
Topics: Acetaminophen; Adult; Developing Countries; Dose-Response Relationship, Drug; Drug Overdose; Female; | 1999 |
Paracetamol overdosage.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Drug Overdose; Humans; Male; Nonprescription Drugs; | 2000 |
Paracetamol hepatotoxicity and alcohol consumption in deliberate and accidental overdose.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Dru | 2000 |
Change in occurrence of paracetamol overdose in UK after introduction of blister packs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Drug Packaging; Female; Humans; Incidence; M | 2000 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Activated charcoal in paracetamol overdose.
Topics: Acetaminophen; Charcoal; Drug Overdose; Evidence-Based Medicine; Humans; MEDLINE; Poisoning | 2000 |
Delays in administration of acetylcysteine in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Drug Overdose; Humans; Ireland; Liver Failur | 2000 |
Chronic salicylism resulting in noncardiogenic pulmonary edema requiring hemodialysis.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Pulmonary Edema; Rena | 2000 |
Acetaminophen hepatoxicity.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Child; Child, Preschool; Drug Overdose; Fema | 2000 |
Index of suspicion. Case 3. Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Femal | 1999 |
Severity of overdose after restriction of paracetamol availability: retrospective study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chi-Square Distribution; Drug Overdose; Humans; Liver Failu | 2000 |
Acetaminophen causes an increased International Normalized Ratio by reducing functional factor VII.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anticoagulants; Blood Coagulation; | 2000 |
Safety of childhood acetaminophen overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Overdos | 2001 |
Protective effect of stiripentol on acetaminophen-induced hepatotoxicity in rat.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Area Under Curve; Aspartate Aminotrans | 2001 |
Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; | 2001 |
Accidental paracetamol overdosing and fulminant hepatic failure in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Drug Overdose; Humans; Liver Failure | 2000 |
Paracetamol (acetaminophen) poisoning: report of two cases.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Charcoal; Dru | 2000 |
Acetaminophen toxicity induced non-oliguric acute tubular necrosis.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Overdose; Female; Humans; Kidney | 2001 |
Hemolytic anemia after acetaminophen overdose in patient with glucose-6-phosphate dehydrogenase deficiency.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anemia, Hemolytic; Drug Overdose; Glucosephosph | 2001 |
Let the user beware. OTC drugs aren't necessarily 'safe when taken as directed.'.
Topics: Acetaminophen; Adult; Common Cold; Diphenhydramine; Drug Combinations; Drug Overdose; Female; Humans | 2001 |
Pediatric acetaminophen poisoning.
Topics: Acetaminophen; Adolescent; Aging; Analgesics, Non-Narcotic; Child; Child, Preschool; Confounding Fac | 2001 |
Severity of overdose after restriction of paracetamol availability. Study's results conflict with those of other papers.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Drug Packaging; Humans; Liver Failure, Acute | 2001 |
Severity of overdose after restriction of paracetamol availability. Restriction has not reduced admissions with self poisoning.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Drug Packaging; Hospitalization; Humans; Inc | 2001 |
[Severe acute intoxication by barbiturates, tranquilizers, tricyclics, paracetamol, salicylates. Diagnosis, treatment].
Topics: Acetaminophen; Antidepressive Agents, Tricyclic; Barbiturates; Diagnosis, Differential; Drug Overdos | 2001 |
Measuring plasma paracetamol concentrations in all patients with drug overdose or altered consciousness: does it change outcome?
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Consciousness Disorders; Di | 2001 |
Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and after study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Overdose; Dru | 2001 |
Acetaminophen toxicity nomogram error: Barkin's Textbook of Pediatric Emergency Medicine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Drug Overdose; Emergency Medicine; Humans; Textbooks | 2001 |
Pediatric acetaminophen overdose.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dose-Response Relati | 2001 |
Acetaminophen toxicity nomogram error: Barkin's Textbook of Pediatric Emergency Medicine.
Topics: Acetaminophen; Child; Child, Preschool; Decision Support Techniques; Drug Overdose; Emergency Medici | 2001 |
Persistently elevated acetaminophen concentrations for two days after an initial four-hour non-toxic concentration.
Topics: Acetaminophen; Barbiturates; Dextropropoxyphene; Drug Combinations; Drug Interactions; Drug Overdose | 2001 |
Measurement of acetaminophen-protein adducts in children and adolescents with acetaminophen overdoses. .
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferas | 2001 |
Temporal profile of total, bound, and free Gc-globulin after acetaminophen overdose.
Topics: Acetaminophen; Actins; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug | 2001 |
Substances used in deliberate self-poisoning 1985-1997: trends and associations with age, gender, repetition and suicide intent.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Analgesics, Non-Narcotic; Antidepressive Agents; | 2001 |
Toxicity of over-the-counter cough and cold medications.
Topics: Acetaminophen; Antitussive Agents; Bradycardia; Brompheniramine; Cardiovascular Diseases; Child, Pre | 2001 |
Effects of legislation restricting pack sizes of paracetamol on self poisoning. It's too early to tell yet.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Drug Packaging; Humans; Legislation, Drug; U | 2001 |
Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver | 2001 |
Acetaminophen toxicity in children.
Topics: Acetaminophen; Adult; Age Factors; Analgesics, Non-Narcotic; Charcoal; Child; Drug Overdose; Humans; | 2001 |
Trends in deaths from drug overdose and poisoning in England and Wales 1993-1998.
Topics: Acetaminophen; Adolescent; Adult; Aged; Antidepressive Agents; Benzodiazepines; Data Collection; Dru | 2001 |
Acute acetaminophen toxicity: report of a case.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug | 2001 |
Paracetamol poisoning resulting in massively raised serum transaminases.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Liver; Middle Aged; Prothrom | 2001 |
Referral patterns and social deprivation in paracetamol-induced liver injury in Scotland.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Legislation, Drug; Li | 2001 |
Fulminant heptic failure in a child following paracetamol overdosing.
Topics: Acetaminophen; Child; Drug Overdose; Fatal Outcome; Humans; Liver Failure; Male | 2001 |
Genomics and proteomics analysis of acetaminophen toxicity in mouse liver.
Topics: Acetaminophen; Animals; Blotting, Western; DNA Adducts; Dose-Response Relationship, Drug; Drug Overd | 2002 |
Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Coma; Diagnosis, Diff | 2001 |
The intravenous use of oral acetylcysteine (mucomyst) for the treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Drug Overdose; Expectorants; Female; Humans; Infusions, I | 2002 |
Is continuous veno-venous hemofiltration for acetaminophen-induced acute liver and renal failure worthwhile?
Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcoholism; Analgesics, Non-Narcotic; Drug Overdose; Hemo | 2002 |
Paracetamol recall: a natural experiment influencing analgesic poisoning.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Australia; Child; Drug and Narcotic Control; Drug | 2002 |
Influence of acute and chronic alcohol intake on the clinical course and outcome in acetaminophen overdose.
Topics: Acetaminophen; Alcoholic Intoxication; Alcoholism; Drug Overdose; Female; Hepatic Encephalopathy; Hu | 2002 |
Safety of paracetamol packaging in the United Kingdom.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Drug Packaging; France; United Kingdom | 2001 |
A prospective study of multiple supratherapeutic acetaminophen doses in febrile children.
Topics: Acetaminophen; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Cohort | 2002 |
Paracetamol poisoning unmasking factor VII deficiency.
Topics: Acetaminophen; Adolescent; Drug Overdose; Factor VII Deficiency; Female; Humans; International Norma | 2002 |
The value of plasma acetaminophen half-life in antidote-treated acetaminophen overdosage.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Varian | 2002 |
Advances, challenges, and controversies in poisoning.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Emergency Medical Services; Humans; Poisonin | 2002 |
Paracetamol overdose: an evidence based flowchart to guide management.
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Drug Overdose; Evidence-Based Medicine; Humans | 2002 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Oral or intravenous antidote for paracetamol overdose.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Evid | 2002 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Vomiting in paracetamol overdose.
Topics: Acetaminophen; Adult; Drug Overdose; Evidence-Based Medicine; Female; Humans; Male; Poisoning; Vomit | 2002 |
Acetaminophen toxicity: suicidal vs. accidental.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; | 2002 |
Concomitant overdosing of other drugs in patients with paracetamol poisoning.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical and Dr | 2002 |
Trends in suicide from drug overdose in the elderly in England and Wales, 1993-1999.
Topics: Acetaminophen; Age Distribution; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Antidepressive | 2002 |
Chronic pain, bereavement and overdose in a depressed elderly woman.
Topics: Acetaminophen; Aged; Aged, 80 and over; Aging; Aortic Aneurysm, Thoracic; Aspirin; Back Pain; Bereav | 2002 |
Acetaminophen poisoning in children: treat early and long enough.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver | 2002 |
Predictors of outcome after acetaminophen poisoning in children and adolescents.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Alanine Transaminase; Analgesics, Non-Narcotic; Arkansas; | 2002 |
A possible trend suggesting increased abuse from Coricidin exposures reported to the Texas Poison Network: comparing 1998 to 1999.
Topics: Acetaminophen; Adolescent; Adolescent Behavior; Age Factors; Antitussive Agents; Child; Chlorphenira | 2002 |
Utility of acetaminophen screening in unsuspected suicidal ingestions.
Topics: Acetaminophen; Adolescent; Adult; Drug Overdose; Female; Humans; Male; Medical Records; Middle Aged; | 2002 |
Pregnancy outcome after suicide attempt by drug use: a Danish population-based study.
Topics: Abortion, Spontaneous; Acetaminophen; Adolescent; Adult; Aspirin; Child; Child, Preschool; Denmark; | 2002 |
Paracetamol recall: a natural experiment influencing analgesic poisoning.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug and Narcotic Control; Drug Overdose; Humans | 2002 |
Acetaminophen toxicity in children.
Topics: Acetaminophen; Age Factors; Charcoal; Child; Drug Overdose; Humans; Practice Guidelines as Topic; Ti | 2002 |
Treatment strategies for early presenting acetaminophen overdose: a survey of medical directors of poison centers in North America and Europe.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Data Collection; Drug Overdose; Europe; Humans; North Ameri | 2002 |
The great pretender.
Topics: Acetaminophen; Antisocial Personality Disorder; Drug Overdose; Humans; Male; Neurosyphilis; Penicill | 1992 |
[Paracetamol overdose: a new form of suicide in Chile and the value of N-acetylcysteine administration].
Topics: Acetaminophen; Acetylcysteine; Adolescent; Chile; Drug Overdose; Female; Humans; Middle Aged; Suicid | 1992 |
Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Anticonvulsants; Drug Interactions; Drug Ove | 1992 |
Respiratory arrest after N-acetylcysteine for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Drug Overdose; Female; Heart Arrest; Humans | 1992 |
Immunolocalization of regenerating cells after submassive liver necrosis using PCNA staining.
Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Immunoh | 1992 |
N-acetylcysteine in treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Cimetidine; Drug Overdose; Drug Therapy, Combination; Humans | 1992 |
Apparent hyperglycaemia in paracetamol overdose.
Topics: Acetaminophen; Adult; Blood Glucose; Drug Overdose; False Positive Reactions; Humans; Hyperglycemia; | 1992 |
Hepatotoxicity from paracetamol self-poisoning in western Sydney: a continuing challenge.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans | 1992 |
Orthotopic liver transplants necessitated by acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Adolescent; Adult; Drug Overdose; Female; Hepatic Encephalopathy; Humans; Liver Trans | 1992 |
Paracetamol overdose in Jerusalem, 1984-89.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; D | 1992 |
Paracetamol overdose in Israel--1992.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Glutathione; H | 1992 |
Evaluating suspected co-proxamol overdose.
Topics: Acetaminophen; Adolescent; Adult; Body Fluids; Dextropropoxyphene; Drug Combinations; Drug Overdose; | 1992 |
Non-fatal deliberate self-poisoning in Dublin's north inner city--an overview.
Topics: Acetaminophen; Adolescent; Adult; Drug Overdose; Female; Humans; Ireland; Male; Middle Aged; Retrosp | 1992 |
Postmortem toxico-kinetics of co-proxamol.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Dextropropoxyphene; Drug Combinations; Drug Overdose; | 1992 |
Recognizing acetaminophen hepatotoxicity in chronic alcoholics.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Ove | 1992 |
Renal impairment associated with an acute paracetamol overdose in the absence of hepatotoxicity.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Drug Overdose; Female; Humans; Kidney | 1992 |
Anaphylactoid reaction to intravenous acetylcysteine associated with electrocardiographic abnormalities.
Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Drug Overdose; Electrocardiography; Female; Human | 1992 |
Is activated charcoal useful for acetaminophen overdose beyond two hours after ingestion?
Topics: Acetaminophen; Charcoal; Drug Overdose; Humans; Infant; Time Factors | 1992 |
Acetaminophen overdose as a suicidal gesture: a survey of adolescents' knowledge of its potential for toxicity.
Topics: Acetaminophen; Adolescent; Attitude to Death; Drug Overdose; Female; Humans; Male; Risk Factors; Sui | 1992 |
Complete heart block after flumazenil.
Topics: Acetaminophen; Aged; Drug Overdose; Female; Flumazenil; Heart Block; Humans; Temazepam | 1991 |
Coagulation factor V and VIII/V ratio as predictors of outcome in paracetamol induced fulminant hepatic failure: relation to other prognostic indicators.
Topics: Acetaminophen; Adolescent; Adult; Drug Overdose; Factor V; Factor VIII; Female; Hepatic Encephalopat | 1992 |
Rhabdomyolysis after suicidal ingestion of an overdose of caffeine, acetaminophen and phenazone as a fixed-dose combination (Spalt N).
Topics: Acetaminophen; Adult; Antipyrine; Caffeine; Creatine Kinase; Drug Combinations; Drug Overdose; Human | 1991 |
Increased elastase-alpha 1-antitrypsin complex in fulminant hepatic failure: relationship to bacterial infection and activation of coagulation.
Topics: Acetaminophen; alpha 1-Antitrypsin; Aspartate Aminotransferases; Bacterial Infections; Bilirubin; Bl | 1991 |
[Hepatic coma of unknown origin in an 18-year-old patient].
Topics: Acetaminophen; Adolescent; Drug Overdose; Electrocardiography; Female; Hepatic Encephalopathy; Human | 1991 |
[Increase in paracetamol poisoning].
Topics: Acetaminophen; Adult; Aged; Cross-Sectional Studies; Drug Overdose; Female; Germany; Humans; Inciden | 1991 |
[Oral administration of activated charcoal-sorbitol suspension as first aid in prevention of poison resorption?].
Topics: Acetaminophen; Charcoal; Codeine; Diphenhydramine; Drug Overdose; Humans; Intestinal Absorption; Met | 1991 |
Fatal acetaminophen poisoning with evidence of subendocardial necrosis of the heart.
Topics: Acetaminophen; Adolescent; Drug Overdose; Endocardium; Female; Heart Transplantation; Humans; Kidney | 1991 |
Liver transplantation after paracetamol overdose.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Decision Making; Drug Overdose; Female | 1991 |
Liver transplantation after paracetamol overdose.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Transplantation | 1991 |
Cimetidine in the treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Cimetidine; Drug Overdose; Drug Therapy, Combination; Female; | 1991 |
Severe thrombocytopenia after paracetamol overdose.
Topics: Acetaminophen; Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; | 1990 |
Thrombin-antithrombin III complex in fulminant hepatic failure: evidence for disseminated intravascular coagulation and relationship to outcome.
Topics: Acetaminophen; Adolescent; Adult; Antithrombin III; Disseminated Intravascular Coagulation; Drug Ove | 1990 |
Paracetamol overdose in children.
Topics: Acetaminophen; Adolescent; Child; Child, Preschool; Drug Overdose; Female; Humans; Incidence; Infant | 1990 |
Severe acetaminophen toxicity in a patient receiving isoniazid.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Interact | 1990 |
Quantitative serum toxic screening in the management of suspected drug overdose.
Topics: Acetaminophen; Alcoholic Intoxication; Antidepressive Agents, Tricyclic; Barbiturates; Blood Chemica | 1990 |
Compound analgesics.
Topics: Acetaminophen; Adult; Drug Combinations; Drug Overdose; Female; Humans; Pentobarbital; Substance-Rel | 1990 |
Safety of late acetylcysteine treatment in paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Drug Overdose; Female; Humans; Male; Middle | 1990 |
Consumption, overdose and death from analgesics during a period of over-the-counter availability of paracetamol in Denmark.
Topics: Acetaminophen; Analgesics; Denmark; Dextropropoxyphene; Drug Overdose; Drug Utilization; Hospitaliza | 1990 |
Parasuicide in central London 1984-1988.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Aspirin; Benzodiazep | 1989 |
Fatal variceal haemorrhage after paracetamol overdose.
Topics: Acetaminophen; Adult; Drug Overdose; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Hu | 1989 |
Ibuprofen vs acetaminophen in children.
Topics: Acetaminophen; Child; Drug Overdose; Fever; Humans; Ibuprofen; Pain; Suspensions | 1989 |
Rebound surges of intracranial pressure as a consequence of forced ultrafiltration used to control intracranial pressure in patients with severe hepatorenal failure.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Brain Edema; Drug Overdose; Female; Hemofiltration; Hepat | 1989 |
Status epilepticus after electroconvulsive therapy.
Topics: Acetaminophen; Adult; Depressive Disorder; Drug Overdose; Electroconvulsive Therapy; Electroencephal | 1989 |