Page last updated: 2024-10-22

acetaminophen and Down Syndrome

acetaminophen has been researched along with Down Syndrome in 3 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)

Research Excerpts

ExcerptRelevanceReference
"In this study we evaluated subjects with Down's syndrome for the possibility that direct or indirect gene dosage effects of trisomy 21 alter the fate of acetaminophen."1.28Noninvasive determination of acetaminophen disposition in Down's syndrome. ( Cooke, RE; Corcoran, GB; Griener, JC; Msall, ME, 1990)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mian, P1
Valkenburg, AJ1
Allegaert, K1
Koch, BCP1
Breatnach, CV1
Knibbe, CAJ1
Tibboel, D1
Krekels, EHJ1
de Knegt, NC1
Evenhuis, HM1
Lobbezoo, F1
Schuengel, C1
Scherder, EJ1
Griener, JC1
Msall, ME1
Cooke, RE1
Corcoran, GB1

Other Studies

3 other studies available for acetaminophen and Down Syndrome

ArticleYear
Population Pharmacokinetic Modeling of Acetaminophen and Metabolites in Children After Cardiac Surgery With Cardiopulmonary Bypass.
    Journal of clinical pharmacology, 2019, Volume: 59, Issue:6

    Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Biological Variation, Populati

2019
Does format matter for comprehension of a facial affective scale and a numeric scale for pain by adults with Down syndrome?
    Research in developmental disabilities, 2013, Volume: 34, Issue:10

    Topics: Acetaminophen; Adult; Affect; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cog

2013
Noninvasive determination of acetaminophen disposition in Down's syndrome.
    Clinical pharmacology and therapeutics, 1990, Volume: 48, Issue:5

    Topics: Acetaminophen; Administration, Oral; Age Factors; Down Syndrome; Female; Humans; Male; Sex Factors

1990