acetaminophen has been researched along with Disease Exacerbation in 58 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a meta-analysis of randomized controlled trials (RCTs) that compared wheezing and asthma exacerbations in children taking paracetamol versus ibuprofen." | 9.05 | Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials. ( Furuya-Kanamori, L; Nader, JD; Sherbash, M; Thalib, L, 2020) |
| "Several studies have shown that colchicine exhibits an improvement in the symptoms of knee osteoarthritis (OA) but its effect on disease progression is unknown." | 7.88 | Does long term colchicine prevent degradation of collagen fiber network in osteoarthritis? ( Agarwal, GG; Asthana, A; Das, SK; Goel, G; Srivastava, R, 2018) |
| "The objectives of this study are to determine the effects of regularly scheduled administration of paracetamol (acetaminophen) on quality of life (QoL), discomfort, pain and neuropsychiatric symptoms of persons with dementia living in long-term care facilities (LTCFs)." | 5.34 | Does paracetamol improve quality of life, discomfort, pain and neuropsychiatric symptoms in persons with advanced dementia living in long-term care facilities? A randomised double-blind placebo-controlled crossover (Q-PID) trial. ( Achterberg, WP; Caljouw, MAA; Husebo, BS; van Dam, PH, 2020) |
| "We conducted a meta-analysis of randomized controlled trials (RCTs) that compared wheezing and asthma exacerbations in children taking paracetamol versus ibuprofen." | 5.05 | Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials. ( Furuya-Kanamori, L; Nader, JD; Sherbash, M; Thalib, L, 2020) |
| " However, randomized trials have demonstrated success with high-dose steroids, cyclosporine, and mycophenolate in treating glomerulonephritis and other complications." | 5.05 | Henoch-Schönlein Purpura (IgA Vasculitis): Rapid Evidence Review. ( Reamy, BV; Servey, JT; Williams, PM, 2020) |
| "Several studies have shown that colchicine exhibits an improvement in the symptoms of knee osteoarthritis (OA) but its effect on disease progression is unknown." | 3.88 | Does long term colchicine prevent degradation of collagen fiber network in osteoarthritis? ( Agarwal, GG; Asthana, A; Das, SK; Goel, G; Srivastava, R, 2018) |
| " For example, epidemiological evidence suggests that coexistent hepatitis C virus (HCV) infection increased the risk of acetaminophen-induced acute liver injury, and was associated with an increased risk of progression to acute liver failure." | 3.79 | Acetaminophen-induced acute liver injury in HCV transgenic mice. ( Boorman, GA; Bradford, BU; Chatterjee, S; Jeannot, E; Kosyk, O; Macdonald, JM; Mason, RP; Melnyk, SB; Pogribny, IP; Rusyn, I; Tech, K; Tryndyak, VP; Uehara, T, 2013) |
| "To determine the clinical characteristics of patients with acute liver failure of indeterminate cause and their long-term outcome in comparison with patients with acute liver failure of obvious aetiology (acetaminophen and mushroom poisoning, Budd-Chiari syndrome, acute viral hepatitis) and other controls (idiosyncratic drug reactions, autoimmune hepatitis and Wilson's disease)." | 3.74 | Long-term follow-up of patients with acute liver failure of indeterminate aetiology. ( Bergquist, A; Björnsson, E; Kalaitzakis, E; Wei, G, 2008) |
| "To describe an in vivo model in the rat in which change in weight distribution is used as a measure of disease progression and efficacy of acetaminophen and two nonsteroidal anti-inflammatory drugs (NSAIDs) in a model of monosodium iodoacetate (MIA)-induced osteoarthritis (OA)." | 3.72 | Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. ( Bove, SE; Brooker, RM; Calcaterra, SL; Guzman, RE; Huber, CM; Juneau, PL; Kilgore, KS; Schrier, DJ, 2003) |
| "Hydrocodone is frequently prescribed in combination with acetaminophen for the relief of pain and has a side effects profile similar to other medications in its class." | 3.70 | Profound hearing loss associated with hydrocodone/acetaminophen abuse. ( Friedman, RA; Gherini, S; House, JW; Luxford, WM; Mills, D, 2000) |
| "Severe infarcts and intracerebral hemorrhages caused temperature to rise, whereas initially increased temperature had no influence on stroke severity." | 2.70 | Stroke severity determines body temperature in acute stroke. ( Boysen, G; Christensen, H, 2001) |
| " There is concern that current NAC dosing is not large enough to adequately treat large APAP ingestions." | 2.61 | Evaluation and treatment of acetaminophen toxicity. ( Curry, SC; Fisher, ES, 2019) |
| " Only pCGS is given as a highly bioavailable once daily dose (1500 mg) with a proven pharmacological effect." | 2.53 | A review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes. ( Bruyère, O; Cooper, C; Kovalenko, V; Kucharz, EJ; Reginster, JY; Szántó, S, 2016) |
| " NSAIDs long-term use associated with serious adverse effects." | 2.48 | [Antiinflammatory therapy in ostheoarthritis including omega 3 and omega 6 fatty acids]. ( Dzielska-Olczak, M; Nowak, JZ, 2012) |
| "Primary osteoarthritis is mostly related to aging, whereas, secondary osteoarthritis is caused by another disease or condition." | 2.43 | Osteoarthritis. ( Mahajan, A; Tandon, V; Verma, S, 2005) |
| "Given that chronic obstructive pulmonary disease (COPD) is frequently co-morbid with osteoarthritis, this study investigated whether the dose and timing of paracetamol exposure may induce COPD exacerbations." | 1.72 | The association between exacerbation of chronic obstructive pulmonary disease and timing of paracetamol use: a cohort study in elderly Australians. ( Gillam, M; Kelly, TL; Pratt, NL; Ramsay, E; Roughead, EE; Ward, M, 2022) |
| "Human liver slice function was stressed by daily dosing of acetaminophen (APAP) or diclofenac (DCF) to investigate injury and repair." | 1.48 | Progression of Repair and Injury in Human Liver Slices. ( Fisher, RL; Ulyanov, AV; Vickers, AEM, 2018) |
| "Pediatric acute-liver-failure due to acetaminophen (APAP) administration at therapeutic dosage is rare, while viral infections and metabolic defects are the prevalent causes." | 1.46 | NBAS mutations cause acute liver failure: when acetaminophen is not a culprit. ( Brunati, A; Calvo, PL; Haak, TB; Olio, DD; Pinon, M; Romagnoli, R; Spada, M; Tandoi, F, 2017) |
| "Acetaminophen use was associated with active disease at follow-up in CD (adjusted RR, 1." | 1.43 | Role of Nonsteroidal Anti-Inflammatory Drugs in Exacerbations of Inflammatory Bowel Disease. ( Anton, K; Chen, W; Kappelman, MD; Long, MD; Martin, CF; Sandler, RS, 2016) |
| "Five patients had recurrences and were treated as outpatients without antibiotics." | 1.42 | Outpatient, non-antibiotic management in acute uncomplicated diverticulitis: a prospective study. ( Andreasson, K; Chabok, A; Isacson, D; Nikberg, M; Smedh, K; Thorisson, A, 2015) |
| "Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of liver damage ranging from steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis." | 1.39 | Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease. ( Cherrington, NJ; Ferreira, DW; Hardwick, RN; Lake, AD; Lu, Z; Manautou, JE; More, VR; Slitt, AL, 2013) |
| "Irreversible acute liver failure, defined as rise in prothrombin time >3 times normal, occurred 19." | 1.39 | A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival. ( Alibhai, H; Baker, LA; Chang, YM; Davies, NA; Jalan, R; L Priestnall, S; Leckie, PJ; Lee, KC; Mookerjee, RP; Palacios Jimenez, C; Stanzani, G, 2013) |
| "Acetaminophen is a safe antipyretic and analgesic drug within the clinically recommended dosage range, but overdose can cause fatal liver and or kidney damage." | 1.38 | Effect of acetaminophen on the progression of renal damage in adenine induced renal failure model rats. ( Arimizu, K; Chuang, VT; Hirata, S; Irie, T; Ishitsuka, Y; Kadowaki, D; Kitamura, K; Maruyama, T; Narita, Y; Otagiri, M; Sumikawa, S; Taguchi, K, 2012) |
| "Progression of hepatic encephalopathy (HE) is a major determinant of outcome in acute liver failure (ALF)." | 1.32 | Infection and the progression of hepatic encephalopathy in acute liver failure. ( Blei, AT; Chung, C; Helenowski, I; Lee, WM; Polson, J; Reisch, J; Schiodt, FV; Vaquero, J, 2003) |
| "C57BL/6 mice were administered a toxic dose of APAP intraperitoneally to cause liver injury with or without depletion of NK and NKT cells by anti-NK1." | 1.32 | Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. ( Govindarajan, S; Kaplowitz, N; Liu, ZX, 2004) |
| "No effect of disease state, AIDS vs asymptomatic HIV positive vs control, on APAP glucuronidation or sulphation was observed." | 1.30 | Glucuronidation and sulphation of paracetamol in HIV-positive patients and patients with AIDS. ( Di Girolamo, A; O'Neil, WM; Pezzullo, JC; Tsoukas, CM; Wainer, IW, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.72) | 18.2507 |
| 2000's | 17 (29.31) | 29.6817 |
| 2010's | 33 (56.90) | 24.3611 |
| 2020's | 7 (12.07) | 2.80 |
| Authors | Studies |
|---|---|
| von Meijenfeldt, FA | 1 |
| Stravitz, RT | 1 |
| Zhang, J | 1 |
| Adelmeijer, J | 1 |
| Zen, Y | 1 |
| Durkalski, V | 1 |
| Lee, WM | 2 |
| Lisman, T | 1 |
| de Bruin, N | 1 |
| Schneider, AK | 1 |
| Reus, P | 1 |
| Talmon, S | 1 |
| Ciesek, S | 1 |
| Bojkova, D | 1 |
| Cinatl, J | 1 |
| Lodhi, I | 1 |
| Charlesworth, B | 1 |
| Sinclair, S | 1 |
| Pennick, G | 1 |
| Laughey, WF | 1 |
| Gribbon, P | 1 |
| Kannt, A | 1 |
| Schiffmann, S | 1 |
| Kelly, TL | 1 |
| Ward, M | 1 |
| Pratt, NL | 1 |
| Ramsay, E | 1 |
| Gillam, M | 1 |
| Roughead, EE | 1 |
| Karpińska, G | 1 |
| Dobrowolski, JC | 1 |
| Yinda, CK | 1 |
| Rector, A | 1 |
| Zeller, M | 1 |
| Conceição-Neto, N | 1 |
| Heylen, E | 1 |
| Maes, P | 1 |
| Ghogomu, SM | 1 |
| Van Ranst, M | 1 |
| Matthijnssens, J | 1 |
| Arthanari, SK | 1 |
| Vanitha, J | 1 |
| Ganesh, M | 1 |
| Venkateshwaran, K | 1 |
| de Lama Caro-Patón, G | 1 |
| García-Salido, A | 1 |
| Iglesias-Bouzas, MI | 1 |
| Guillén, M | 1 |
| Cañedo-Villaroya, E | 1 |
| Martínez-Romera, I | 1 |
| Serrano-González, A | 1 |
| Casado-Flores, J | 1 |
| Gale, P | 2 |
| Chen, X | 2 |
| Li, H | 1 |
| Lucero-Prisno, DE | 1 |
| Abdullah, AS | 1 |
| Huang, J | 1 |
| Laurence, C | 1 |
| Liang, X | 1 |
| Ma, Z | 1 |
| Mao, Z | 1 |
| Ren, R | 1 |
| Wu, S | 1 |
| Wang, N | 1 |
| Wang, P | 2 |
| Wang, T | 1 |
| Yan, H | 1 |
| Zou, Y | 1 |
| Olsen, KM | 1 |
| Gabler, NK | 1 |
| Rademacher, CJ | 1 |
| Schwartz, KJ | 1 |
| Schweer, WP | 1 |
| Gourley, GG | 1 |
| Patience, JF | 1 |
| Rauch, JC | 1 |
| Stokes, RS | 1 |
| Shike, DW | 1 |
| Luebbe, KM | 1 |
| Stalker, LA | 1 |
| Klopfenstein, TJ | 1 |
| Funston, RN | 1 |
| Unger, PA | 1 |
| Lighaam, LC | 1 |
| Vermeulen, E | 1 |
| Kruithof, S | 1 |
| Makuch, M | 1 |
| Culver, EL | 1 |
| van Bruggen, R | 1 |
| Remmerswaal, EBM | 1 |
| Ten Berge, IJM | 1 |
| Emmens, RW | 1 |
| Niessen, HWM | 1 |
| Barnes, E | 1 |
| Wolbink, GJ | 1 |
| van Ham, SM | 1 |
| Rispens, T | 1 |
| Liang, JX | 1 |
| Lin, J | 1 |
| Liu, J | 1 |
| Wang, X | 1 |
| Zhang, T | 1 |
| Li, J | 1 |
| Wu, Y | 2 |
| Venier, M | 1 |
| Salamova, A | 1 |
| Gonçales, VR | 1 |
| Lian, J | 1 |
| Gautam, S | 1 |
| Tilley, RD | 1 |
| Gooding, JJ | 1 |
| Kandel, YR | 1 |
| Bradley, CA | 1 |
| Chilvers, MI | 1 |
| Mathew, FM | 1 |
| Tenuta, AU | 1 |
| Smith, DL | 1 |
| Wise, KA | 1 |
| Mueller, DS | 1 |
| Lu, N | 1 |
| Lu, M | 1 |
| Liu, P | 1 |
| Xu, H | 1 |
| Qiu, X | 1 |
| Hu, S | 1 |
| Bai, S | 1 |
| Wu, J | 1 |
| Xue, S | 1 |
| Dai, X | 1 |
| Dharmage, SC | 1 |
| Abramson, MJ | 1 |
| Erbas, B | 1 |
| Bennett, CM | 1 |
| Svanes, C | 1 |
| Hui, J | 1 |
| Axelrad, C | 1 |
| Lowe, AJ | 1 |
| Lodge, CJ | 1 |
| Hoshi, M | 1 |
| Osawa, Y | 1 |
| Nakamoto, K | 1 |
| Morita, N | 1 |
| Yamamoto, Y | 1 |
| Ando, T | 1 |
| Tashita, C | 1 |
| Nabeshima, T | 1 |
| Saito, K | 1 |
| Gianesello, L | 1 |
| Del Prete, D | 1 |
| Ceol, M | 1 |
| Priante, G | 1 |
| Calò, LA | 1 |
| Anglani, F | 1 |
| Vekaria, HJ | 1 |
| Hubbard, WB | 1 |
| Scholpa, NE | 1 |
| Spry, ML | 1 |
| Gooch, JL | 1 |
| Prince, SJ | 1 |
| Schnellmann, RG | 1 |
| Sullivan, PG | 1 |
| Zhang, Q | 1 |
| Hu, R | 1 |
| Gu, Z | 1 |
| Zhang, M | 1 |
| Zhang, Z | 1 |
| Peng, Y | 1 |
| Feng, L | 1 |
| Li, X | 3 |
| Zhao, C | 1 |
| Sarfaraz, K | 1 |
| Gao, L | 1 |
| Wang, H | 1 |
| Wan, C | 1 |
| Leng, J | 1 |
| Yang, P | 1 |
| Gao, X | 1 |
| Gao, J | 1 |
| Emam, HE | 1 |
| Saad, NM | 1 |
| Abdallah, AEM | 1 |
| Ahmed, HB | 1 |
| Palombo, M | 1 |
| Ianus, A | 1 |
| Guerreri, M | 1 |
| Nunes, D | 1 |
| Alexander, DC | 1 |
| Shemesh, N | 1 |
| Zhang, H | 1 |
| Xiong, Q | 1 |
| Liu, YS | 1 |
| Hu, LX | 1 |
| Shi, ZQ | 1 |
| Ying, GG | 1 |
| Chen, R | 1 |
| Hong, X | 1 |
| Yan, S | 1 |
| Zha, J | 1 |
| Gu, H | 1 |
| Zhong, Q | 1 |
| Zeng, Y | 1 |
| Zhang, S | 1 |
| Bu, Y | 1 |
| Farghali, M | 1 |
| Mayumi, M | 1 |
| Syo, K | 1 |
| Satoshi, A | 1 |
| Seiichi, Y | 1 |
| Takashima, S | 1 |
| Ono, H | 1 |
| Ap, Y | 1 |
| Yamashiro, T | 1 |
| Ahmed, MM | 1 |
| Kotb, S | 1 |
| Iwasaki, M | 1 |
| Ihara, I | 1 |
| Umetsu, K | 1 |
| Hu, B | 2 |
| Wang, Y | 2 |
| Quan, J | 1 |
| Huang, K | 1 |
| Gu, X | 1 |
| Zhu, J | 1 |
| Yan, Y | 1 |
| Wu, P | 1 |
| Yang, L | 1 |
| Zhao, J | 1 |
| Koók, L | 1 |
| Nemestóthy, N | 1 |
| Bélafi-Bakó, K | 1 |
| Bakonyi, P | 1 |
| Luo, X | 1 |
| Zhang, F | 1 |
| Li, Q | 1 |
| Xia, Q | 1 |
| Li, Z | 1 |
| Ye, W | 1 |
| Li, S | 1 |
| Ge, C | 1 |
| Zakkula, A | 1 |
| Pulipati, S | 1 |
| Dittakavi, S | 1 |
| Bestha, RM | 1 |
| Zainuddin, M | 1 |
| Trivedi, RK | 1 |
| Mullangi, R | 1 |
| Lo, GH | 1 |
| Lin, CW | 1 |
| Tai, CM | 1 |
| Perng, DS | 1 |
| Chen, IL | 1 |
| Yeh, JH | 1 |
| Lin, HC | 1 |
| Rocha, GS | 1 |
| Silva, MKL | 1 |
| Cesarino, I | 1 |
| Hazzaa, SM | 1 |
| Abdelaziz, SAM | 1 |
| Abd Eldaim, MA | 1 |
| Abdel-Daim, MM | 1 |
| Elgarawany, GE | 1 |
| Larsson, P | 1 |
| Ljuslinder, I | 1 |
| Öhlund, D | 1 |
| Myte, R | 1 |
| Löfgren-Burström, A | 1 |
| Zingmark, C | 1 |
| Ling, A | 1 |
| Edin, S | 1 |
| Palmqvist, R | 1 |
| Murthi, P | 1 |
| Rajaraman, G | 1 |
| Erwich, JJHM | 1 |
| Dimitriadis, E | 1 |
| Yoon, HG | 1 |
| Oh, D | 1 |
| Ahn, YC | 1 |
| Noh, JM | 1 |
| Pyo, H | 1 |
| Cho, WK | 1 |
| Song, YM | 1 |
| Park, M | 1 |
| Hwang, NY | 1 |
| Sun, JM | 1 |
| Kim, HK | 1 |
| Zo, JI | 1 |
| Shim, YM | 1 |
| Persano, A | 1 |
| Quaranta, F | 1 |
| Taurino, A | 1 |
| Siciliano, PA | 1 |
| Iannacci, J | 1 |
| Malekbala, MR | 1 |
| Soltani, S | 1 |
| Abdul Rashid, S | 1 |
| Abdullah, LC | 1 |
| Rashid, U | 1 |
| Nehdi, IA | 1 |
| Choong, TSY | 1 |
| Teo, SH | 1 |
| Xu, P | 1 |
| Yan, F | 1 |
| Zhao, Y | 1 |
| Sun, S | 1 |
| Ying, L | 1 |
| Quinzi, V | 1 |
| Caruso, S | 1 |
| Mummolo, S | 1 |
| Nota, A | 1 |
| Angelone, AM | 1 |
| Mattei, A | 1 |
| Gatto, R | 1 |
| Marzo, G | 1 |
| Xin, W | 1 |
| Severino, J | 1 |
| Venkert, A | 1 |
| Yu, H | 1 |
| Knorr, D | 1 |
| Yang, JM | 1 |
| Carlson, L | 1 |
| Hicks, R | 1 |
| De Rosa, I | 1 |
| Beckmann, NA | 1 |
| Bitsch, RG | 1 |
| Schonhoff, M | 1 |
| Siebenrock, KA | 1 |
| Schwarze, M | 1 |
| Jaeger, S | 1 |
| Sherbash, M | 1 |
| Furuya-Kanamori, L | 1 |
| Nader, JD | 1 |
| Thalib, L | 1 |
| Mitsuboshi, S | 1 |
| Yamada, H | 1 |
| Yamazaki, S | 1 |
| Kobayashi, M | 1 |
| Ueno, K | 1 |
| Nagai, K | 1 |
| Reamy, BV | 1 |
| Servey, JT | 1 |
| Williams, PM | 1 |
| van Dam, PH | 1 |
| Achterberg, WP | 1 |
| Husebo, BS | 1 |
| Caljouw, MAA | 1 |
| Lee, KCL | 1 |
| Baker, L | 1 |
| Mallett, S | 1 |
| Riddell, A | 1 |
| Chowdary, P | 1 |
| Alibhai, H | 2 |
| Chang, YM | 2 |
| Priestnall, S | 1 |
| Stanzani, G | 2 |
| Davies, N | 1 |
| Mookerjee, R | 1 |
| Jalan, R | 3 |
| Agarwal, B | 1 |
| Calvo, PL | 1 |
| Tandoi, F | 1 |
| Haak, TB | 1 |
| Brunati, A | 1 |
| Pinon, M | 1 |
| Olio, DD | 1 |
| Romagnoli, R | 1 |
| Spada, M | 1 |
| Zabron, A | 1 |
| Quaglia, A | 1 |
| Fatourou, E | 1 |
| Peddu, P | 1 |
| Lewis, D | 1 |
| Heneghan, M | 1 |
| Willars, C | 1 |
| Auzinger, G | 1 |
| Heaton, N | 1 |
| Wendon, J | 1 |
| Kane, P | 1 |
| Karani, J | 1 |
| Bernal, W | 1 |
| Moninuola, OO | 1 |
| Milligan, W | 1 |
| Lochhead, P | 1 |
| Khalili, H | 1 |
| Heinzl, S | 1 |
| Mitsui, S | 1 |
| Katayama, C | 1 |
| Aoyama, Y | 1 |
| Mizukawa, Y | 1 |
| Kuyama, M | 1 |
| Kawakami, Y | 1 |
| Vickers, AEM | 1 |
| Ulyanov, AV | 1 |
| Fisher, RL | 1 |
| Nicholas, WA | 1 |
| Moore, R | 1 |
| Fisher, ES | 1 |
| Curry, SC | 1 |
| Shah, N | 1 |
| Montes de Oca, M | 1 |
| Jover-Cobos, M | 1 |
| Tanamoto, K | 1 |
| Muroi, M | 1 |
| Sugiyama, K | 1 |
| Davies, NA | 2 |
| Mookerjee, RP | 2 |
| Dhar, DK | 1 |
| Cavassani, KA | 1 |
| Moreira, AP | 1 |
| Habiel, D | 1 |
| Ito, T | 1 |
| Coelho, AL | 1 |
| Allen, RM | 1 |
| Raphelson, J | 1 |
| Carson, WF | 1 |
| Schaller, MA | 1 |
| Lukacs, NW | 1 |
| Omary, MB | 2 |
| Hogaboam, CM | 1 |
| Kunkel, SL | 1 |
| El Sayed, SM | 1 |
| Mohamed, WG | 1 |
| Seddik, MA | 1 |
| Ahmed, AS | 1 |
| Mahmoud, AG | 1 |
| Amer, WH | 1 |
| Helmy Nabo, MM | 1 |
| Hamed, AR | 1 |
| Ahmed, NS | 1 |
| Abd-Allah, AA | 1 |
| Guldiken, N | 1 |
| Zhou, Q | 1 |
| Kucukoglu, O | 1 |
| Rehm, M | 1 |
| Levada, K | 1 |
| Gross, A | 1 |
| Kwan, R | 1 |
| James, LP | 1 |
| Trautwein, C | 1 |
| Strnad, P | 1 |
| Isacson, D | 1 |
| Thorisson, A | 1 |
| Andreasson, K | 1 |
| Nikberg, M | 1 |
| Smedh, K | 1 |
| Chabok, A | 1 |
| Szabo, G | 1 |
| Petrasek, J | 1 |
| Long, MD | 1 |
| Kappelman, MD | 1 |
| Martin, CF | 1 |
| Chen, W | 1 |
| Anton, K | 1 |
| Sandler, RS | 1 |
| Kucharz, EJ | 1 |
| Kovalenko, V | 1 |
| Szántó, S | 1 |
| Bruyère, O | 1 |
| Cooper, C | 1 |
| Reginster, JY | 1 |
| Venkatesan, P | 1 |
| Srivastava, R | 1 |
| Das, SK | 1 |
| Goel, G | 1 |
| Asthana, A | 1 |
| Agarwal, GG | 1 |
| Sakulchit, T | 1 |
| Goldman, RD | 1 |
| Wei, G | 1 |
| Kalaitzakis, E | 1 |
| Bergquist, A | 1 |
| Björnsson, E | 1 |
| Tan, HH | 1 |
| Chang, CY | 1 |
| Martin, P | 1 |
| Mehta, G | 1 |
| Rothstein, KD | 1 |
| Lopez, DP | 1 |
| Malfait, AM | 1 |
| Ritchie, J | 1 |
| Gil, AS | 1 |
| Austin, JS | 1 |
| Hartke, J | 1 |
| Qin, W | 1 |
| Tortorella, MD | 1 |
| Mogil, JS | 1 |
| Newsome, PN | 1 |
| Henderson, NC | 1 |
| Nelson, LJ | 1 |
| Dabos, C | 1 |
| Filippi, C | 1 |
| Bellamy, C | 1 |
| Howie, F | 1 |
| Clutton, RE | 1 |
| King, T | 1 |
| Lee, A | 1 |
| Hayes, PC | 1 |
| Plevris, JN | 1 |
| Kuo, HW | 1 |
| Tsai, SS | 1 |
| Tiao, MM | 1 |
| Liu, YC | 1 |
| Lee, IM | 1 |
| Yang, CY | 1 |
| Bhave, VS | 2 |
| Donthamsetty, S | 1 |
| Latendresse, JR | 2 |
| Cunningham, ML | 1 |
| Mehendale, HM | 4 |
| Dzielska-Olczak, M | 1 |
| Nowak, JZ | 1 |
| Pagano, MB | 1 |
| Hobbs, W | 1 |
| Linenberger, M | 1 |
| Delaney, M | 1 |
| Carbone, LD | 1 |
| Satterfield, S | 1 |
| Liu, C | 1 |
| Kwoh, KC | 1 |
| Neogi, T | 1 |
| Tolley, E | 1 |
| Nevitt, M | 1 |
| Kadowaki, D | 1 |
| Sumikawa, S | 1 |
| Arimizu, K | 1 |
| Taguchi, K | 1 |
| Kitamura, K | 1 |
| Ishitsuka, Y | 1 |
| Narita, Y | 1 |
| Irie, T | 1 |
| Chuang, VT | 1 |
| Maruyama, T | 1 |
| Otagiri, M | 1 |
| Hirata, S | 1 |
| Uehara, T | 1 |
| Kosyk, O | 1 |
| Jeannot, E | 1 |
| Bradford, BU | 1 |
| Tech, K | 1 |
| Macdonald, JM | 1 |
| Boorman, GA | 1 |
| Chatterjee, S | 1 |
| Mason, RP | 1 |
| Melnyk, SB | 1 |
| Tryndyak, VP | 1 |
| Pogribny, IP | 1 |
| Rusyn, I | 1 |
| Hardwick, RN | 1 |
| Ferreira, DW | 1 |
| More, VR | 1 |
| Lake, AD | 1 |
| Lu, Z | 1 |
| Manautou, JE | 1 |
| Slitt, AL | 1 |
| Cherrington, NJ | 1 |
| Lee, KC | 1 |
| Palacios Jimenez, C | 1 |
| Leckie, PJ | 1 |
| Baker, LA | 1 |
| L Priestnall, S | 1 |
| Takagi, K | 1 |
| Vaquero, J | 1 |
| Polson, J | 1 |
| Chung, C | 1 |
| Helenowski, I | 1 |
| Schiodt, FV | 1 |
| Reisch, J | 1 |
| Blei, AT | 1 |
| Limaye, PB | 2 |
| Apte, UM | 2 |
| Shankar, K | 1 |
| Bucci, TJ | 1 |
| Warbritton, A | 1 |
| Bove, SE | 1 |
| Calcaterra, SL | 1 |
| Brooker, RM | 1 |
| Huber, CM | 1 |
| Guzman, RE | 1 |
| Juneau, PL | 1 |
| Schrier, DJ | 1 |
| Kilgore, KS | 1 |
| Liu, ZX | 1 |
| Govindarajan, S | 1 |
| Kaplowitz, N | 1 |
| Wu, CW | 1 |
| Kalunian, KC | 1 |
| Rosmawati, M | 1 |
| Mahajan, A | 1 |
| Verma, S | 1 |
| Tandon, V | 1 |
| Palkar, PS | 1 |
| Sawant, SP | 1 |
| Yu, S | 1 |
| Reddy, JK | 1 |
| Schmidt, LE | 1 |
| Larsen, FS | 1 |
| O'Neil, WM | 1 |
| Pezzullo, JC | 1 |
| Di Girolamo, A | 1 |
| Tsoukas, CM | 1 |
| Wainer, IW | 1 |
| Friedman, RA | 1 |
| House, JW | 1 |
| Luxford, WM | 1 |
| Gherini, S | 1 |
| Mills, D | 1 |
| Boysen, G | 1 |
| Christensen, H | 1 |
| Bourdi, M | 1 |
| Reilly, TP | 1 |
| Elkahloun, AG | 1 |
| George, JW | 1 |
| Pohl, LR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Multicentric Controlled Clinical Trial of Parallel Groups to Evaluate the Non-therapeutic Inferiority of a Free Diet With a Progressive Diet, in the Treatment of Non-complicated Acute Diverticulitis[NCT03496090] | 134 participants (Actual) | Interventional | 2018-04-16 | Completed | |||
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 reviews available for acetaminophen and Disease Exacerbation
| Article | Year |
|---|---|
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials.
Topics: Acetaminophen; Asthma; Child; Disease Progression; Humans; Ibuprofen; Randomized Controlled Trials a | 2020 |
Henoch-Schönlein Purpura (IgA Vasculitis): Rapid Evidence Review.
Topics: Acetaminophen; Adrenal Cortex Hormones; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N | 2020 |
Systematic review with meta-analysis: association between acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of Crohn's disease and ulcerative colitis exacerbation.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Colitis, Ulcerative; C | 2018 |
Evaluation and treatment of acetaminophen toxicity.
Topics: Acetaminophen; Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Disease Progression; | 2019 |
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.
Topics: Acetaminophen; Adult; Carcinoma, Hepatocellular; Disease Progression; Drug Therapy, Combination; Enz | 2014 |
Inflammasome activation and function in liver disease.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Disease Prog | 2015 |
A review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Dietary Supplements; Disease Progression; Gl | 2016 |
Acetaminophen use and asthma in children.
Topics: Acetaminophen; Age Factors; Antipyretics; Asthma; Child; Child, Preschool; Disease Progression; Dose | 2017 |
Health maintenance issues in cirrhosis.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Comorbidity; Disease Progression; Health | 2009 |
Emergency: acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Antidotes; Charcoal; Chemical and Drug Induced Liver Inju | 2009 |
Once initiated, how does toxic tissue injury expand?
Topics: Acetaminophen; Animals; Calpain; Cell Death; Disease Progression; Free Radicals; Humans; Soft Tissue | 2012 |
[Antiinflammatory therapy in ostheoarthritis including omega 3 and omega 6 fatty acids].
Topics: Acetaminophen; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Chondroitin Sulfat | 2012 |
New developments in osteoarthritis.
Topics: Acetaminophen; Acupuncture Therapy; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non | 2005 |
Osteoarthritis.
Topics: Acetaminophen; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Bone Remodeling; Cartilage, Art | 2005 |
4 trials available for acetaminophen and Disease Exacerbation
| Article | Year |
|---|---|
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Does paracetamol improve quality of life, discomfort, pain and neuropsychiatric symptoms in persons with advanced dementia living in long-term care facilities? A randomised double-blind placebo-controlled crossover (Q-PID) trial.
Topics: Acetaminophen; Aged; Aged, 80 and over; Cross-Over Studies; Dementia; Disease Progression; Double-Bl | 2020 |
[In process].
Topics: Acetaminophen; Asthma; Child, Preschool; Disease Progression; Fever; Humans; Ibuprofen; Pain; Prospe | 2016 |
Stroke severity determines body temperature in acute stroke.
Topics: Acetaminophen; Acute Disease; Aged; Aged, 80 and over; Anticoagulants; Body Temperature; Cerebral He | 2001 |
40 other studies available for acetaminophen and Disease Exacerbation
| Article | Year |
|---|---|
Generation of neutrophil extracellular traps in patients with acute liver failure is associated with poor outcome.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cell-Free Nucleic Acids; Disease Progression; Extrac | 2022 |
Ibuprofen, Flurbiprofen, Etoricoxib or Paracetamol Do Not Influence ACE2 Expression and Activity In Vitro or in Mice and Do Not Exacerbate In-Vitro SARS-CoV-2 Infection.
Topics: Acetaminophen; Angiotensin-Converting Enzyme 2; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ca | 2022 |
The association between exacerbation of chronic obstructive pulmonary disease and timing of paracetamol use: a cohort study in elderly Australians.
Topics: Acetaminophen; Aged; Australia; Cohort Studies; Disease Progression; Humans; Pulmonary Disease, Chro | 2022 |
[Is Concomitant Therapy with Acetaminophen and Low-dose Aspirin a Risk Factor for CKD Progression? A 6-Year Cohort Study].
Topics: Acetaminophen; Adult; Age Factors; Aged; Aged, 80 and over; Aspirin; Biomarkers; Creatinine; Diabete | 2020 |
Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs.
Topics: Acetaminophen; Animals; Biomarkers; Blood Cell Count; Blood Coagulation; Blood Coagulation Factors; | 2017 |
NBAS mutations cause acute liver failure: when acetaminophen is not a culprit.
Topics: Acetaminophen; Diagnosis, Differential; Disease Progression; Fever; Genetic Predisposition to Diseas | 2017 |
Clinical and prognostic associations of liver volume determined by computed tomography in acute liver failure.
Topics: Acetaminophen; Adult; Budd-Chiari Syndrome; Decision Support Techniques; Disease Progression; Female | 2018 |
Local desensitization and progression of multiple fixed drug eruption.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Disease Progression; Drug Eruptions; Erythema; Female; Huma | 2018 |
Progression of Repair and Injury in Human Liver Slices.
Topics: Acetaminophen; Adenosine Triphosphate; Diclofenac; Disease Progression; Gene Expression Regulation; | 2018 |
Using the 150 rule to prevent hepatotoxicity from acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Diagnosis, Differential; Disease Progression; Drug Overdo | 2019 |
Role of toll-like receptor 4 in mediating multiorgan dysfunction in mice with acetaminophen induced acute liver failure.
Topics: Acetaminophen; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Cytokines; D | 2013 |
Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Antibodies, Neutralizing; Chemical and Drug Induced Liver Injury; Chemokines | 2013 |
Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c-jun amino-terminal kinase activation and protein adduct formation.
Topics: Acetaminophen; Animals; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Hum | 2015 |
Outpatient, non-antibiotic management in acute uncomplicated diverticulitis: a prospective study.
Topics: Abdominal Abscess; Abdominal Pain; Acetaminophen; Acute Disease; Aged; Ambulatory Care; Analgesics; | 2015 |
Role of Nonsteroidal Anti-Inflammatory Drugs in Exacerbations of Inflammatory Bowel Disease.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ul | 2016 |
Paracetamol no worse than ibuprofen in children with mild asthma.
Topics: Acetaminophen; Asthma; Child; Child, Preschool; Disease Progression; Female; Humans; Ibuprofen; Male | 2016 |
Does long term colchicine prevent degradation of collagen fiber network in osteoarthritis?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antirheumatic Agents; Biomarkers; Cartilage Oligomeric Matr | 2018 |
Long-term follow-up of patients with acute liver failure of indeterminate aetiology.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Budd-Chiari Syndrome; Disease Progression; Female; F | 2008 |
Acetaminophen hepatotoxicity: current management.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Cimetidi | 2009 |
ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Disease Mode | 2010 |
Development of an invasively monitored porcine model of acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme System; Disease Models, Animal; Disease Progression; | 2010 |
Analgesic use and the risk for progression of chronic kidney disease.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin | 2010 |
Secretory phospholipase A₂-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclooxyge | 2011 |
Plasma and red cell exchange transfusions for erythropoietic protoporphyria: a case report and review of the literature.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Arthroplasty, Replacement, Knee; Cholestasis, Intrahepatic; | 2012 |
Assistive walking device use and knee osteoarthritis: results from the Health, Aging and Body Composition Study (Health ABC Study).
Topics: Acetaminophen; Age Factors; Aged; Analgesics, Non-Narcotic; Canes; Disease Progression; Eye Diseases | 2013 |
Effect of acetaminophen on the progression of renal damage in adenine induced renal failure model rats.
Topics: Acetaminophen; Adenine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antioxidants; Disea | 2012 |
Acetaminophen-induced acute liver injury in HCV transgenic mice.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Inj | 2013 |
Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease.
Topics: Acetaminophen; Biotransformation; Disease Progression; Fatty Liver; Gene Expression Regulation, Enzy | 2013 |
A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Animals; Biomarkers; Cardiovascular Diseases; Chemic | 2013 |
Body temperature in acute stroke.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Body Temperature; Disease Progression; Fever; Huma | 2002 |
Infection and the progression of hepatic encephalopathy in acute liver failure.
Topics: Acetaminophen; Adult; Disease Progression; Female; Hepatic Encephalopathy; Humans; Infections; Liver | 2003 |
Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants.
Topics: Acetaminophen; Animals; Blotting, Western; Calpain; Carbon Tetrachloride; Carrier Proteins; Chemical | 2003 |
Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis | 2003 |
Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cytokines; Disease Progression; Female; Humans; Ki | 2004 |
Aetiology and classification of acute liver failure.
Topics: Acetaminophen; Disease Progression; Hepatitis A; Hepatitis B; Humans; Liver Failure, Acute; Risk Fac | 2005 |
Upregulation of calpastatin in regenerating and developing rat liver: role in resistance against hepatotoxicity.
Topics: Acetaminophen; Animals; Animals, Newborn; Calcium-Binding Proteins; Calpain; Carbon Tetrachloride; C | 2006 |
MELD score as a predictor of liver failure and death in patients with acetaminophen-induced liver injury.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Child; Disease | 2007 |
Glucuronidation and sulphation of paracetamol in HIV-positive patients and patients with AIDS.
Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Adult; Cross-Sectional Studies; Disease Progressi | 1999 |
Profound hearing loss associated with hydrocodone/acetaminophen abuse.
Topics: Acetaminophen; Adult; Analgesics; Cochlear Implantation; Disease Progression; Drug Combinations; Fem | 2000 |
Macrophage migration inhibitory factor in drug-induced liver injury: a role in susceptibility and stress responsiveness.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Biotransformation; Chemical and Drug Induc | 2002 |