acetaminophen has been researched along with Diathesis in 22 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The degree of liver inflammation and hepatocellular necrosis were significantly higher in HFGD fed animals after acetaminophen administration." | 7.78 | Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. ( Cervinková, Z; Haňáčková, L; Kučera, O; Lotková, H; Podhola, M; Roušar, T; Staňková, P, 2012) |
| " No clear dose-response relationship existed between the quantity of paracetamol ingested and the observed concentrations of 5-oxoproline." | 6.49 | What is the clinical significance of 5-oxoproline (pyroglutamic acid) in high anion gap metabolic acidosis following paracetamol (acetaminophen) exposure? ( Liss, DB; Mullins, ME; Paden, MS; Schwarz, ES, 2013) |
| " For example, epidemiological evidence suggests that coexistent hepatitis C virus (HCV) infection increased the risk of acetaminophen-induced acute liver injury, and was associated with an increased risk of progression to acute liver failure." | 3.79 | Acetaminophen-induced acute liver injury in HCV transgenic mice. ( Boorman, GA; Bradford, BU; Chatterjee, S; Jeannot, E; Kosyk, O; Macdonald, JM; Mason, RP; Melnyk, SB; Pogribny, IP; Rusyn, I; Tech, K; Tryndyak, VP; Uehara, T, 2013) |
| "The degree of liver inflammation and hepatocellular necrosis were significantly higher in HFGD fed animals after acetaminophen administration." | 3.78 | Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. ( Cervinková, Z; Haňáčková, L; Kučera, O; Lotková, H; Podhola, M; Roušar, T; Staňková, P, 2012) |
| " No clear dose-response relationship existed between the quantity of paracetamol ingested and the observed concentrations of 5-oxoproline." | 2.49 | What is the clinical significance of 5-oxoproline (pyroglutamic acid) in high anion gap metabolic acidosis following paracetamol (acetaminophen) exposure? ( Liss, DB; Mullins, ME; Paden, MS; Schwarz, ES, 2013) |
| " C57BL/6N and C57BL/6J mice were dosed with 200 mg/kg APAP and sacrificed at different time points." | 1.43 | Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J. ( Bourdi, M; Cahkraborty, M; Davis, JS; Du, K; Duan, L; Jaeschke, H; Weemhoff, J; Woolbright, BL, 2016) |
| " Significant positive dose-response effects of early life use were seen in relation to the prevalence of all outcomes at age 5." | 1.40 | Effects of early life paracetamol use on the incidence of allergic disease and sensitization: 5 year follow-up of an Ethiopian birth cohort. ( Amberbir, A; Britton, J; Davey, G; Hanlon, C; Medhin, G; Venn, A, 2014) |
| "Ecabapide was administered orally to SHRSP in various dose-regimens." | 1.30 | Ecabapide, a novel gastroprokinetic agent, ameliorates gastric emptying of stroke-prone spontaneously hypertensive rats (SHRSP). ( Furuhama, K, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 13 (59.09) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Chandan, JS | 1 |
| Zemedikun, DT | 1 |
| Thayakaran, R | 1 |
| Byne, N | 1 |
| Dhalla, S | 1 |
| Acosta-Mena, D | 1 |
| Gokhale, KM | 1 |
| Thomas, T | 1 |
| Sainsbury, C | 1 |
| Subramanian, A | 1 |
| Cooper, J | 1 |
| Anand, A | 1 |
| Okoth, KO | 1 |
| Wang, J | 1 |
| Adderley, NJ | 1 |
| Taverner, T | 1 |
| Denniston, AK | 1 |
| Lord, J | 1 |
| Thomas, GN | 1 |
| Buckley, CD | 1 |
| Raza, K | 1 |
| Bhala, N | 1 |
| Nirantharakumar, K | 1 |
| Haroon, S | 1 |
| Garrone, B | 1 |
| Durando, L | 1 |
| Prenderville, J | 1 |
| Sokolowska, E | 1 |
| Milanese, C | 1 |
| Di Giorgio, FP | 1 |
| Callaghan, C | 1 |
| Bianchi, M | 1 |
| Sasaki, Y | 1 |
| Yoshino, N | 1 |
| Okuwa, T | 1 |
| Odagiri, T | 1 |
| Satoh, T | 1 |
| Muraki, Y | 1 |
| Zheng, J | 1 |
| Zhou, H | 1 |
| Yang, T | 1 |
| Liu, J | 1 |
| Qin, T | 1 |
| Gu, X | 1 |
| Wu, J | 1 |
| Zhang, Y | 1 |
| Wang, H | 1 |
| Tang, Y | 1 |
| Xue, F | 1 |
| Mao, Y | 1 |
| Xia, Q | 1 |
| Liss, DB | 1 |
| Paden, MS | 1 |
| Schwarz, ES | 1 |
| Mullins, ME | 1 |
| Amberbir, A | 1 |
| Medhin, G | 1 |
| Hanlon, C | 1 |
| Britton, J | 1 |
| Davey, G | 1 |
| Venn, A | 1 |
| Du, K | 2 |
| Williams, CD | 1 |
| McGill, MR | 1 |
| Jaeschke, H | 2 |
| Zhang, J | 1 |
| Song, S | 1 |
| Pang, Q | 1 |
| Zhang, R | 1 |
| Zhou, L | 1 |
| Liu, S | 1 |
| Meng, F | 1 |
| Wu, Q | 1 |
| Liu, C | 1 |
| Duan, L | 1 |
| Davis, JS | 1 |
| Woolbright, BL | 1 |
| Cahkraborty, M | 1 |
| Weemhoff, J | 1 |
| Bourdi, M | 1 |
| Singh, MP | 1 |
| Kim, KY | 1 |
| Kim, HY | 1 |
| Kon, K | 1 |
| Ikejima, K | 1 |
| Okumura, K | 1 |
| Arai, K | 1 |
| Aoyama, T | 1 |
| Watanabe, S | 1 |
| Kučera, O | 1 |
| Roušar, T | 1 |
| Staňková, P | 1 |
| Haňáčková, L | 1 |
| Lotková, H | 1 |
| Podhola, M | 1 |
| Cervinková, Z | 1 |
| Masubuchi, Y | 1 |
| Nakayama, J | 1 |
| Watanabe, Y | 1 |
| de Meijer, VE | 1 |
| Kalish, BT | 1 |
| Meisel, JA | 1 |
| Le, HD | 1 |
| Puder, M | 1 |
| Hou, HS | 1 |
| Liao, CL | 1 |
| Sytwu, HK | 1 |
| Liao, NS | 1 |
| Huang, TY | 1 |
| Hsieh, TY | 1 |
| Chu, HC | 1 |
| Martin-Murphy, BV | 1 |
| Kominsky, DJ | 1 |
| Orlicky, DJ | 1 |
| Donohue, TM | 1 |
| Ju, C | 1 |
| Uehara, T | 1 |
| Kosyk, O | 1 |
| Jeannot, E | 1 |
| Bradford, BU | 1 |
| Tech, K | 1 |
| Macdonald, JM | 1 |
| Boorman, GA | 1 |
| Chatterjee, S | 1 |
| Mason, RP | 1 |
| Melnyk, SB | 1 |
| Tryndyak, VP | 1 |
| Pogribny, IP | 1 |
| Rusyn, I | 1 |
| Welch, KD | 1 |
| Wen, B | 1 |
| Goodlett, DR | 1 |
| Yi, EC | 1 |
| Lee, H | 1 |
| Reilly, TP | 1 |
| Nelson, SD | 1 |
| Pohl, LR | 1 |
| Furuhama, K | 1 |
| Nolan, J | 1 |
| Prosser, DP | 1 |
| Adamson, GM | 1 |
| Papadimitriou, JM | 1 |
| Harman, AW | 1 |
| Price, VF | 1 |
| Jollow, DJ | 1 |
1 review available for acetaminophen and Diathesis
| Article | Year |
|---|---|
What is the clinical significance of 5-oxoproline (pyroglutamic acid) in high anion gap metabolic acidosis following paracetamol (acetaminophen) exposure?
Topics: Acetaminophen; Acetylcysteine; Acidosis; Amino Acid Metabolism, Inborn Errors; Analgesics, Non-Narco | 2013 |
21 other studies available for acetaminophen and Diathesis
| Article | Year |
|---|---|
Nonsteroidal Antiinflammatory Drugs and Susceptibility to COVID-19.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; | 2021 |
Paracetamol (acetaminophen) rescues cognitive decline, neuroinflammation and cytoskeletal alterations in a model of post-operative cognitive decline (POCD) in middle-aged rats.
Topics: Acetaminophen; Age Factors; Analgesics; Anesthetics; Animals; Cognition; Cognitive Dysfunction; Cyto | 2021 |
A mouse monoclonal antibody against influenza C virus attenuates acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Acetyl-CoA C-Acyltransferase; Animals; Antibodies, Monoclonal; Antibody Specificity; | 2021 |
Protective Role of microRNA-31 in Acetaminophen-Induced Liver Injury: A Negative Regulator of c-Jun N-Terminal Kinase (JNK) Signaling Pathway.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury, Chronic; Disease Models, | 2021 |
Effects of early life paracetamol use on the incidence of allergic disease and sensitization: 5 year follow-up of an Ethiopian birth cohort.
Topics: Acetaminophen; Age of Onset; Asthma; Child, Preschool; Cohort Studies; Cross-Sectional Studies; Deve | 2014 |
Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anthracenes; Chemical and Drug Induced Liver Injur | 2014 |
Serotonin deficiency exacerbates acetaminophen-induced liver toxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cell Prolifera | 2015 |
Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J.
Topics: Acetaminophen; Animals; Blotting, Western; Chemical and Drug Induced Liver Injury; Disease Susceptib | 2016 |
Methionine sulfoxide reductase A deficiency exacerbates acute liver injury induced by acetaminophen.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Susceptibility; Gene Deletio | 2017 |
Diabetic KK-A(y) mice are highly susceptible to oxidative hepatocellular damage induced by acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Death; Chemical and Drug Induced Liver Injury | 2010 |
Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen.
Topics: Acetaminophen; Animals; Biomarkers; Caspase 3; Chemical and Drug Induced Liver Injury; Cholesterol; | 2012 |
Sex difference in susceptibility to acetaminophen hepatotoxicity is reversed by buthionine sulfoximine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Buthionine Sulfoximine; Disease Susceptibility; Fe | 2011 |
Dietary fish oil aggravates paracetamol-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2013 |
Deficiency of interleukin-15 enhances susceptibility to acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Antibodies, Neutralizing; Chemical and Drug Induced Liver Injury; Disease Su | 2012 |
Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Antigens, CD1d; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP | 2013 |
Acetaminophen-induced acute liver injury in HCV transgenic mice.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Inj | 2013 |
Proteomic identification of potential susceptibility factors in drug-induced liver disease.
Topics: Acetaminophen; Affinity Labels; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Aff | 2005 |
Ecabapide, a novel gastroprokinetic agent, ameliorates gastric emptying of stroke-prone spontaneously hypertensive rats (SHRSP).
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Ulcer Agents; Autonomic | 1997 |
Prevention of postoperative vomiting with granisetron in paediatric patients with and without a history of motion sickness.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Antiemetics; Child; Disease Susceptibil | 2000 |
Postnatal mice have low susceptibility to paracetamol toxicity.
Topics: Acetaminophen; Age Factors; Animals; Animals, Newborn; Benzoquinones; Chemical and Drug Induced Live | 1991 |
Strain differences in susceptibility of normal and diabetic rats to acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Experimental; Dis | 1986 |