acetaminophen has been researched along with Diabetic Neuropathies in 15 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compared the efficacy and safety of tramadol/acetaminophen (T/A) and gabapentin in the management of painful diabetic neuropathy." | 9.14 | Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy. ( Baik, SH; Cha, BY; Kim, CH; Kim, DS; Ko, KS; Ko, SH; Kwon, HS; Lee, JH; Mok, JO; Noh, JH; Park, IB; Park, TS; Son, HS; Yu, JM, 2010) |
| "This study compared the efficacy and safety of tramadol/acetaminophen (T/A) and gabapentin in the management of painful diabetic neuropathy." | 5.14 | Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy. ( Baik, SH; Cha, BY; Kim, CH; Kim, DS; Ko, KS; Ko, SH; Kwon, HS; Lee, JH; Mok, JO; Noh, JH; Park, IB; Park, TS; Son, HS; Yu, JM, 2010) |
| " the proportional cumulative area under the curve of paracetamol) was utilized in diabetic patients in order to detect both gastroparesis and the influence of metoclopramide, a known prokinetic drug, on this condition." | 5.08 | The proportional cumulative area under the curve of paracetamol used as an index of gastric emptying in diabetic patients with symptoms of gastroparesis. ( Moncrieff, J; Snyman, JR; Sommers, DK; van Wyk, M, 1995) |
| "Tramadol/APAP was associated with significantly greater improvement than placebo (p < or = 0." | 2.73 | Randomized study of tramadol/acetaminophen versus placebo in painful diabetic peripheral neuropathy. ( Freeman, R; Hewitt, DJ; Jordan, DM; Raskin, P; Rosenthal, NR; Vorsanger, GJ; Xiang, J, 2007) |
| "Amitriptyline was the only antidepressant prescribed commonly as a first-line treatment." | 1.39 | An observational descriptive study of the epidemiology and treatment of neuropathic pain in a UK general population. ( Carroll, D; Gabriel, ZL; Hall, GC; McQuay, HJ; Morant, SV, 2013) |
| "Patients were classified as diabetic autonomic neuropathy positive or negative using five standardized haemodynamic reflex tests." | 1.31 | Evaluation of standard haemodynamic tests of autonomic function and HbA1c as predictors of delayed gastric emptying in patients with type 1 diabetes mellitus. ( Cooke, T; Duggan, PF; Lydon, A; Murray, C; O'Halloran, D; Shorten, GD, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hall, GC | 1 |
| Morant, SV | 1 |
| Carroll, D | 1 |
| Gabriel, ZL | 1 |
| McQuay, HJ | 1 |
| Micov, A | 1 |
| Tomić, M | 1 |
| Pecikoza, U | 1 |
| Ugrešić, N | 1 |
| Stepanović-Petrović, R | 1 |
| Déciga-Campos, M | 1 |
| Ortíz-Andrade, R | 1 |
| Zirakzadeh, A | 1 |
| Herlein, A | 1 |
| Groß, MA | 1 |
| Mereiter, K | 1 |
| Wang, Y | 1 |
| Weissensteiner, W | 1 |
| Cuaderes, E | 1 |
| DeShea, L | 1 |
| Lamb, WL | 1 |
| Yamada, T | 1 |
| Takasu, A | 1 |
| Vijayan, A | 1 |
| Li, T | 1 |
| Dusso, A | 1 |
| Jain, S | 1 |
| Coyne, DW | 1 |
| Ben Saad, H | 1 |
| Driss, D | 1 |
| Ben Amara, I | 1 |
| Boudawara, O | 1 |
| Boudawara, T | 1 |
| Ellouz Chaabouni, S | 1 |
| Mounir Zeghal, K | 1 |
| Hakim, A | 1 |
| Zhou, Y | 1 |
| Prediger, P | 1 |
| Dias, LC | 1 |
| Murphy, AC | 1 |
| Leadlay, PF | 1 |
| Puillandre, N | 1 |
| Duda, TF | 1 |
| Meyer, C | 1 |
| Olivera, BM | 1 |
| Bouchet, P | 1 |
| Vermang, B | 1 |
| Wätjen, JT | 1 |
| Fjällström, V | 1 |
| Rostvall, F | 1 |
| Edoff, M | 1 |
| Kotipalli, R | 1 |
| Henry, F | 1 |
| Flandre, D | 1 |
| Hamilton, ER | 1 |
| Samek, DR | 1 |
| Keyes, M | 1 |
| McGue, MK | 1 |
| Iacono, WG | 1 |
| Valcour, A | 1 |
| Zierold, C | 1 |
| Podgorski, AL | 1 |
| Olson, GT | 1 |
| Wall, JV | 1 |
| DeLuca, HF | 1 |
| Bonelli, F | 1 |
| Morton, TL | 1 |
| Devarakonda, K | 1 |
| Kostenbader, K | 1 |
| Montgomery, J | 1 |
| Barrett, T | 1 |
| Webster, L | 1 |
| Miltiades, P | 1 |
| Lamprianidou, E | 1 |
| Kerzeli, IK | 1 |
| Nakou, E | 1 |
| Papamichos, SI | 1 |
| Spanoudakis, E | 1 |
| Kotsianidis, I | 1 |
| Rahbar, MH | 1 |
| Samms-Vaughan, M | 1 |
| Ma, J | 1 |
| Bressler, J | 1 |
| Dickerson, AS | 1 |
| Hessabi, M | 1 |
| Loveland, KA | 1 |
| Grove, ML | 1 |
| Shakespeare-Pellington, S | 1 |
| Beecher, C | 1 |
| McLaughlin, W | 1 |
| Boerwinkle, E | 1 |
| Fujisawa, Y | 1 |
| Napoli, E | 1 |
| Wong, S | 1 |
| Song, G | 1 |
| Yamaguchi, R | 1 |
| Matsui, T | 1 |
| Nagasaki, K | 1 |
| Ogata, T | 1 |
| Giulivi, C | 1 |
| Pietrzycka, A | 1 |
| Kózka, M | 1 |
| Urbanek, T | 1 |
| Stpniewski, M | 1 |
| Kucharzewski, M | 1 |
| Huang, TQ | 1 |
| Zou, MX | 1 |
| Pasek, DA | 1 |
| Meissner, G | 1 |
| Hersey, SP | 1 |
| Garland, RM | 1 |
| Crosbie, E | 1 |
| Shingler, T | 1 |
| Sorooshian, A | 1 |
| Piketh, S | 1 |
| Burger, R | 1 |
| Chang, LC | 1 |
| Yue, J | 1 |
| Wang, W | 1 |
| Wu, Q | 1 |
| Meier, RR | 1 |
| Han, L | 1 |
| Jia, Y | 1 |
| Song, Q | 1 |
| Wang, N | 1 |
| Wang, J | 1 |
| Bai, B | 1 |
| Chen, X | 1 |
| Wang, C | 1 |
| Cheng, Y | 1 |
| Kim, MH | 1 |
| Lee, YS | 1 |
| Lee, MS | 1 |
| Anderson, LG | 1 |
| Dunn, AM | 1 |
| Rosewarne, PJ | 1 |
| Stebbing, PD | 1 |
| Nicolas, F | 1 |
| Wu, C | 1 |
| Bukhari, S | 1 |
| de Toledo, SM | 1 |
| Li, H | 1 |
| Shibata, M | 1 |
| Azzam, EI | 1 |
| Smucny, J | 1 |
| Stevens, KE | 1 |
| Tregellas, JR | 1 |
| Karuppuchamy, S | 1 |
| Brundha, C | 1 |
| Wilkens, MR | 1 |
| Maté, LM | 1 |
| Schnepel, N | 1 |
| Klinger, S | 1 |
| Muscher-Banse, AS | 1 |
| Ballent, M | 1 |
| Virkel, G | 1 |
| Lifschitz, AL | 1 |
| Simpson, RW | 1 |
| Wlodarczyk, JH | 1 |
| Ko, SH | 1 |
| Kwon, HS | 1 |
| Yu, JM | 1 |
| Baik, SH | 1 |
| Park, IB | 1 |
| Lee, JH | 1 |
| Ko, KS | 1 |
| Noh, JH | 1 |
| Kim, DS | 1 |
| Kim, CH | 1 |
| Mok, JO | 1 |
| Park, TS | 1 |
| Son, HS | 1 |
| Cha, BY | 1 |
| Gong, YH | 1 |
| Yu, XR | 1 |
| Liu, HL | 1 |
| Yang, N | 1 |
| Zuo, PP | 1 |
| Huang, YG | 1 |
| Wernicke, JF | 2 |
| Pritchett, YL | 2 |
| D'Souza, DN | 2 |
| Waninger, A | 1 |
| Tran, P | 1 |
| Iyengar, S | 2 |
| Raskin, J | 2 |
| Freeman, R | 1 |
| Raskin, P | 1 |
| Hewitt, DJ | 1 |
| Vorsanger, GJ | 1 |
| Jordan, DM | 1 |
| Xiang, J | 1 |
| Rosenthal, NR | 1 |
| Wang, F | 1 |
| Smith, TR | 1 |
| Chappell, AS | 1 |
| Danilov, AB | 1 |
| Zharkova, TR | 1 |
| van Wyk, M | 1 |
| Sommers, DK | 1 |
| Snyman, JR | 1 |
| Moncrieff, J | 1 |
| Feng, B | 1 |
| Li, Y | 1 |
| Li, C | 1 |
| Lydon, A | 1 |
| Murray, C | 1 |
| Cooke, T | 1 |
| Duggan, PF | 1 |
| O'Halloran, D | 1 |
| Shorten, GD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Pregabalin and Duloxetine in Patients With Painful Diabetic Peripheral Neuropathy (PDPN): the Effect of Pain on Cognitive Function, Sleep and Quality of Life (BLOSSOM)[NCT04246619] | Phase 4 | 254 participants (Actual) | Interventional | 2019-11-12 | Terminated (stopped due to The statistical analysis will still provide relevant results with the same statistical power as initially planned.COVID-19 pandemic prolonged the recruiting period and consequently affected the costs of the clinical trial.) | ||
| A Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Tramadol HCl/Acetaminophen for the Treatment of Painful Diabetic Neuropathy[NCT00210847] | Phase 3 | 313 participants (Actual) | Interventional | 2003-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 trials available for acetaminophen and Diabetic Neuropathies
| Article | Year |
|---|---|
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Advanced Oxidation Protein Products; Aged; A | 2015 |
Transdermal Buprenorphine Relieves Neuropathic Pain: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial in Diabetic Peripheral Neuropathic Pain.
Topics: Acetaminophen; Administration, Cutaneous; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2016 |
Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy.
Topics: Acetaminophen; Adult; Aged; Amines; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Diabetes Mellit | 2010 |
A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain.
Topics: Acetaminophen; Adrenergic Uptake Inhibitors; Aged; Analgesics, Non-Narcotic; Diabetic Neuropathies; | 2006 |
Randomized study of tramadol/acetaminophen versus placebo in painful diabetic peripheral neuropathy.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Diab | 2007 |
An open-label 52-week clinical extension comparing duloxetine with routine care in patients with diabetic peripheral neuropathic pain.
Topics: Acetaminophen; Amitriptyline; Analgesics; Carbamazepine; Diabetes Complications; Diabetic Neuropathi | 2007 |
The proportional cumulative area under the curve of paracetamol used as an index of gastric emptying in diabetic patients with symptoms of gastroparesis.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Diabetes Mellitus, Type 1; Diabetic Neuropathi | 1995 |
8 other studies available for acetaminophen and Diabetic Neuropathies
| Article | Year |
|---|---|
An observational descriptive study of the epidemiology and treatment of neuropathic pain in a UK general population.
Topics: Acetaminophen; Adolescent; Adult; Aged; Amines; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, | 2013 |
Levetiracetam synergises with common analgesics in producing antinociception in a mouse model of painful diabetic neuropathy.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Diabetic Neuropathies; Dose-Response Relationship, Drug | 2015 |
Enhancement of Antihyperalgesia by the Coadministration of N-palmitoylethanolamide and Acetaminophen in Diabetic Rats.
Topics: Acetaminophen; Amides; Analgesics; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; | 2015 |
Antinociceptive effects of combination of tramadol and acetaminophen on painful diabetic neuropathy in streptozotocin-induced diabetic rats.
Topics: Acetaminophen; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Therapy, Combin | 2011 |
[Pharmacotherapy with zaldiar of the pain syndrome in diabetic polyneuropathy].
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Diab | 2007 |
[Acetaminophen absorption test for determination of diabetic gastroparesis and effects of erythromycin on gastric emptying].
Topics: Absorption; Acetaminophen; Diabetes Complications; Diabetic Neuropathies; Erythromycin; Female; Gast | 1996 |
Drugs for pain.
Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics | 1998 |
Evaluation of standard haemodynamic tests of autonomic function and HbA1c as predictors of delayed gastric emptying in patients with type 1 diabetes mellitus.
Topics: Absorption; Acetaminophen; Analgesics, Non-Narcotic; Area Under Curve; Autonomic Nervous System; Aut | 2000 |