acetaminophen has been researched along with Diabetes Mellitus, Type 2 in 41 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compared the efficacy and safety of tramadol/acetaminophen (T/A) and gabapentin in the management of painful diabetic neuropathy." | 9.14 | Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy. ( Baik, SH; Cha, BY; Kim, CH; Kim, DS; Ko, KS; Ko, SH; Kwon, HS; Lee, JH; Mok, JO; Noh, JH; Park, IB; Park, TS; Son, HS; Yu, JM, 2010) |
| "We examined the contributions of insulin secretion, glucagon suppression, splanchnic and peripheral glucose metabolism, and delayed gastric emptying to the attenuation of postprandial hyperglycemia during intravenous exenatide administration." | 7.74 | Mechanism of action of exenatide to reduce postprandial hyperglycemia in type 2 diabetes. ( Cersosimo, E; Cervera, A; DeFronzo, RA; Fernandez, M; Musi, N; Sriwijitkamol, A; Triplitt, C; Wajcberg, E; Zuo, P, 2008) |
| "This study compared the efficacy and safety of tramadol/acetaminophen (T/A) and gabapentin in the management of painful diabetic neuropathy." | 5.14 | Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy. ( Baik, SH; Cha, BY; Kim, CH; Kim, DS; Ko, KS; Ko, SH; Kwon, HS; Lee, JH; Mok, JO; Noh, JH; Park, IB; Park, TS; Son, HS; Yu, JM, 2010) |
| "We examined the contributions of insulin secretion, glucagon suppression, splanchnic and peripheral glucose metabolism, and delayed gastric emptying to the attenuation of postprandial hyperglycemia during intravenous exenatide administration." | 3.74 | Mechanism of action of exenatide to reduce postprandial hyperglycemia in type 2 diabetes. ( Cersosimo, E; Cervera, A; DeFronzo, RA; Fernandez, M; Musi, N; Sriwijitkamol, A; Triplitt, C; Wajcberg, E; Zuo, P, 2008) |
| "Acetaminophen (APAP) can cause erroneously high readings in real-time continuous glucose monitoring (rtCGM) systems." | 2.87 | Resistance to Acetaminophen Interference in a Novel Continuous Glucose Monitoring System. ( Balo, AK; Calhoun, P; Hughes, J; Johnson, TK; Price, D, 2018) |
| "Acetaminophen is a commonly used analgesic and antipyretic drug, and is frequently used to study gastric emptying." | 2.76 | The effect of the once-daily human glucagon-like peptide 1 analog liraglutide on the pharmacokinetics of acetaminophen. ( Flint, A; Hindsberger, C; Kapitza, C; Zdravkovic, M, 2011) |
| "Twenty-five patients (45-73 years) with type 2 diabetes [glycated haemoglobin (HbA1c) 6." | 2.73 | Pre-operative carbohydrate loading may be used in type 2 diabetes patients. ( Gustafsson, UO; Hagström-Toft, E; Hellström, PM; Ljungqvist, O; Nygren, J; Soop, M; Thorell, A, 2008) |
| "Sixteen NIDDM patients (4 patients treated with diet therapy alone and 12 receiving a sulfonylurea) were given 0." | 2.68 | Relationship between gastric emptying and an alpha-glucosidase inhibitor effect on postprandial hyperglycemia in NIDDM patients. ( Emoto, M; Inaba, M; Ishimura, E; Kawagishi, T; Morii, H; Nishizawa, Y; Okuno, Y; Tanaka, S; Taniwaki, H, 1997) |
| "Eight NIDDM in-patients participated without drop-outs." | 2.67 | The glycaemic index of spaghetti and gastric emptying in non-insulin-dependent diabetic patients. ( Andreasen, F; Christiansen, C; Hermansen, K; Poulsen, PL; Rasmussen, OW; Thomsen, C, 1994) |
| " Because NSAIDs are associated with adverse renal effects, they should be used cautiously in patients with advanced renal disease." | 2.43 | Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease. ( Johnson, J; Weinryb, J, 2006) |
| "Semaglutide is a glucagon-like-peptide-1 (GLP-1) analogue marketed for once-weekly subcutaneous administration for type 2 diabetes mellitus." | 1.72 | Population pharmacokinetic of paracetamol and atorvastatin with co-administration of semaglutide. ( Kristensen, K; Langeskov, EK, 2022) |
| "Acetaminophen was added to the basal diet at 0, 80, 253, 800, 2530, or 8000 ppm and administered to type 2 diabetes mellitus rats (GK/Jcl) and the control male rats (Wistar) for 13 weeks." | 1.56 | Preexisting diabetes mellitus had no effect on the no-observed-adverse-effect-level of acetaminophen in rats. ( Hashimoto, N; Imaida, K; Kanie, S; Kishi, S; Matsuda, Y; Nakano-Narusawa, Y; Saoo, K; Yamakawa, K; Yokohira, M, 2020) |
| "Some patients encounter hepatotoxicity after repeated acetaminophen (APAP) dosing even at therapeutic doses." | 1.56 | Enhancement of acetaminophen-induced chronic hepatotoxicity in spontaneously diabetic torii (SDT) rats. ( Hashimoto, T; Kobayashi, A; Kondo, K; Sugai, S; Suzuki, Y; Takahashi, T; Toyoda, K; Yamada, N; Yoshinari, K, 2020) |
| "Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis, is an uncommon condition that is clinically characterized by painful, well-demarcated, indurated, erythematous plaques or nodules that typically favor the head, neck, and arms, and are accompanied by fever." | 1.46 | Sweet syndrome induced by oral acetaminophen-codeine following repair of a facial fracture. ( Bradley, LM; Halder, RM; Higgins, SP; Rodney, IJ; Thomas, MM, 2017) |
| "Whether patients with type 2 diabetes mellitus (T2DM) are able to regulate their incretin effect is unknown." | 1.37 | Impaired regulation of the incretin effect in patients with type 2 diabetes. ( Bagger, JI; Holst, JJ; Knop, FK; Lund, A; Vestergaard, H; Vilsbøll, T, 2011) |
| "Acetaminophen was co-administered to assess the effects of CGA on gastric emptying." | 1.37 | Chlorogenic acid differentially affects postprandial glucose and glucose-dependent insulinotropic polypeptide response in rats. ( Eller, LK; Hittel, DS; Reimer, RA; Shearer, J; Tunnicliffe, JM, 2011) |
| " In C57BL/6J mice, streptozotocin caused a dosage dependent increase in fasting blood glucose (FBG), from 100 to >600mg/dl." | 1.35 | Acetaminophen normalizes glucose homeostasis in mouse models for diabetes. ( Clegg, DJ; D'Alessio, DA; Genter, MB; Kendig, EL; Schneider, SN; Shertzer, HG, 2008) |
| " We studied the effects of TRZ on the hepatotoxicity of carbon tetrachloride (CCl(4)) and acetaminophen (APAP) in rats, both of which exert their toxic effects through bioactivation associated with cytochrome P450 3A (CYP3A) and 2E1 (CYP2E1)." | 1.31 | Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats. ( Kaneko, T; Li, J; Qin, LQ; Sato, A; Wang, PY; Wang, Y, 2002) |
| " However, the area under the plasma concentration time curve and the elimination half-life of paracetamol metabolites increased significantly with worsening renal insufficiency." | 1.30 | Single-dose pharmacokinetics of paracetamol and its conjugates in Chinese non-insulin-dependent diabetic patients with renal impairment. ( Anderson, PJ; Chan, JC; Chan, MT; Critchley, JA; Lau, GS, 1997) |
| "Phenacetin was removed from the German market in 1986 and was replaced mainly in analgesic compounds by acetaminophen." | 1.30 | Incidence of analgesic nephropathy in Berlin since 1983. ( Preuschof, L; Schwarz, A; Zellner, D, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.44) | 18.7374 |
| 1990's | 8 (19.51) | 18.2507 |
| 2000's | 12 (29.27) | 29.6817 |
| 2010's | 11 (26.83) | 24.3611 |
| 2020's | 9 (21.95) | 2.80 |
| Authors | Studies |
|---|---|
| Cassady, BA | 1 |
| McDonald, JD | 1 |
| Yalawar, M | 1 |
| Baggs, GE | 1 |
| Maki, KC | 1 |
| Langeskov, EK | 1 |
| Kristensen, K | 1 |
| Yonezuka, Y | 1 |
| Kuwada, H | 1 |
| Imaishi, H | 1 |
| Zhou, C | 1 |
| Wu, Q | 1 |
| Ye, Z | 1 |
| Zhang, Y | 3 |
| Yang, S | 1 |
| Liu, M | 1 |
| He, P | 1 |
| Qin, X | 1 |
| Qutob, HMH | 1 |
| Saad, RA | 1 |
| Bali, H | 1 |
| Osailan, A | 1 |
| Jaber, J | 1 |
| Alzahrani, E | 1 |
| Alyami, J | 1 |
| Elsayed, H | 1 |
| Alserihi, R | 1 |
| Shaikhomar, OA | 1 |
| Divya, KM | 1 |
| Savitha, DP | 1 |
| Krishna, GA | 1 |
| Dhanya, TM | 1 |
| Mohanan, PV | 1 |
| Shah, SF | 1 |
| Jafry, AT | 1 |
| Hussain, G | 1 |
| Kazim, AH | 1 |
| Ali, M | 1 |
| Rivani, E | 1 |
| Endraswari, PD | 1 |
| Widodo, ADW | 1 |
| Khalil, MR | 1 |
| Guldberg, R | 1 |
| Nørgård, BM | 1 |
| Uldbjerg, N | 1 |
| Wehberg, S | 1 |
| Fowobaje, KR | 1 |
| Mashood, LO | 1 |
| Ekholuenetale, M | 1 |
| Ibidoja, OJ | 1 |
| Romagnoli, A | 1 |
| D'Agostino, M | 1 |
| Pavoni, E | 1 |
| Ardiccioni, C | 1 |
| Motta, S | 1 |
| Crippa, P | 1 |
| Biagetti, G | 1 |
| Notarstefano, V | 1 |
| Rexha, J | 1 |
| Perta, N | 1 |
| Barocci, S | 1 |
| Costabile, BK | 1 |
| Colasurdo, G | 1 |
| Caucci, S | 1 |
| Mencarelli, D | 1 |
| Turchetti, C | 1 |
| Farina, M | 1 |
| Pierantoni, L | 1 |
| La Teana, A | 1 |
| Al Hadi, R | 1 |
| Cicconardi, F | 1 |
| Chinappi, M | 1 |
| Trucchi, E | 1 |
| Mancia, F | 1 |
| Menzo, S | 1 |
| Morozzo Della Rocca, B | 1 |
| D'Annessa, I | 1 |
| Di Marino, D | 1 |
| Choya, A | 1 |
| de Rivas, B | 1 |
| Gutiérrez-Ortiz, JI | 1 |
| López-Fonseca, R | 1 |
| Xu, S | 1 |
| Cheng, B | 1 |
| Huang, Z | 1 |
| Liu, T | 1 |
| Li, Y | 1 |
| Jiang, L | 1 |
| Guo, W | 1 |
| Xiong, J | 1 |
| Amirazodi, M | 1 |
| Daryanoosh, F | 1 |
| Mehrabi, A | 1 |
| Gaeini, A | 1 |
| Koushkie Jahromi, M | 1 |
| Salesi, M | 1 |
| Zarifkar, AH | 1 |
| Studeny, P | 1 |
| Netukova, M | 1 |
| Nemcokova, M | 1 |
| Klimesova, YM | 1 |
| Krizova, D | 1 |
| Kang, H | 1 |
| Tao, Y | 1 |
| Zhang, Q | 1 |
| Sha, D | 1 |
| Chen, Y | 1 |
| Yao, J | 1 |
| Gao, Y | 1 |
| Liu, J | 1 |
| Ji, L | 1 |
| Shi, P | 1 |
| Shi, C | 1 |
| Wu, YL | 1 |
| Wright, AI | 1 |
| M El-Metwaly, N | 1 |
| A Katouah, H | 1 |
| El-Desouky, MG | 1 |
| El-Bindary, AA | 1 |
| El-Bindary, MA | 1 |
| Kostakis, ID | 1 |
| Raptis, DA | 1 |
| Davidson, BR | 1 |
| Iype, S | 1 |
| Nasralla, D | 1 |
| Imber, C | 1 |
| Sharma, D | 1 |
| Pissanou, T | 1 |
| Pollok, JM | 1 |
| Hughes, AM | 1 |
| Sanderson, E | 1 |
| Morris, T | 1 |
| Ayorech, Z | 1 |
| Tesli, M | 1 |
| Ask, H | 1 |
| Reichborn-Kjennerud, T | 1 |
| Andreassen, OA | 1 |
| Magnus, P | 1 |
| Helgeland, Ø | 1 |
| Johansson, S | 1 |
| Njølstad, P | 1 |
| Davey Smith, G | 1 |
| Havdahl, A | 1 |
| Howe, LD | 1 |
| Davies, NM | 1 |
| Amrillah, T | 1 |
| Prasetio, A | 1 |
| Supandi, AR | 1 |
| Sidiq, DH | 1 |
| Putra, FS | 1 |
| Nugroho, MA | 1 |
| Salsabilla, Z | 1 |
| Azmi, R | 1 |
| Grammatikopoulos, P | 1 |
| Bouloumis, T | 1 |
| Steinhauer, S | 1 |
| Mironov, VS | 2 |
| Bazhenova, TA | 2 |
| Manakin, YV | 2 |
| Yagubskii, EB | 2 |
| Yakushev, IA | 1 |
| Gilmutdinov, IF | 1 |
| Simonov, SV | 1 |
| Lan, K | 1 |
| Yang, H | 1 |
| Zheng, J | 1 |
| Hu, H | 1 |
| Zhu, T | 1 |
| Zou, X | 1 |
| Hu, B | 1 |
| Liu, H | 1 |
| Olokede, O | 1 |
| Wu, H | 1 |
| Holtzapple, M | 1 |
| Gungor, O | 1 |
| Kose, M | 1 |
| Ghaemi, R | 1 |
| Acker, M | 1 |
| Stosic, A | 1 |
| Jacobs, R | 1 |
| Selvaganapathy, PR | 1 |
| Ludwig, N | 1 |
| Yerneni, SS | 1 |
| Azambuja, JH | 1 |
| Pietrowska, M | 1 |
| Widłak, P | 1 |
| Hinck, CS | 1 |
| Głuszko, A | 1 |
| Szczepański, MJ | 1 |
| Kärmer, T | 1 |
| Kallinger, I | 1 |
| Schulz, D | 1 |
| Bauer, RJ | 1 |
| Spanier, G | 1 |
| Spoerl, S | 1 |
| Meier, JK | 1 |
| Ettl, T | 1 |
| Razzo, BM | 1 |
| Reichert, TE | 1 |
| Hinck, AP | 1 |
| Whiteside, TL | 1 |
| Wei, ZL | 1 |
| Juan, W | 1 |
| Tong, D | 1 |
| Juan, LX | 1 |
| Sa, LY | 1 |
| Jie, HFM | 1 |
| Xiao, G | 1 |
| Xiang, LG | 1 |
| Jie, HM | 1 |
| Xu, C | 1 |
| Yu, DN | 1 |
| Yao, ZX | 1 |
| Bigdeli, F | 1 |
| Gao, XM | 1 |
| Cheng, X | 1 |
| Li, JZ | 1 |
| Zhang, JW | 1 |
| Wang, W | 2 |
| Guan, ZJ | 1 |
| Bu, Y | 1 |
| Liu, KG | 1 |
| Morsali, A | 1 |
| Das, R | 1 |
| Paul, R | 1 |
| Parui, A | 1 |
| Shrotri, A | 1 |
| Atzori, C | 1 |
| Lomachenko, KA | 1 |
| Singh, AK | 1 |
| Mondal, J | 1 |
| Peter, SC | 1 |
| Florimbio, AR | 1 |
| Coughlin, LN | 1 |
| Bauermeister, JA | 1 |
| Young, SD | 1 |
| Zimmerman, MA | 1 |
| Walton, MA | 1 |
| Bonar, EE | 1 |
| Demir, D | 1 |
| Balci, AB | 1 |
| Kahraman, N | 1 |
| Sunbul, SA | 1 |
| Gucu, A | 1 |
| Seker, IB | 1 |
| Badem, S | 1 |
| Yuksel, A | 1 |
| Ozyazicioglu, AF | 1 |
| Goncu, MT | 1 |
| Zhang, H | 1 |
| Zhou, H | 1 |
| Deng, Z | 1 |
| Luo, L | 1 |
| Ong, SP | 1 |
| Wang, C | 1 |
| Xin, H | 1 |
| Whittingham, MS | 1 |
| Zhou, G | 1 |
| Maemura, R | 1 |
| Wakamatsu, M | 1 |
| Matsumoto, K | 1 |
| Sakaguchi, H | 1 |
| Yoshida, N | 1 |
| Hama, A | 1 |
| Yoshida, T | 1 |
| Miwata, S | 1 |
| Kitazawa, H | 1 |
| Narita, K | 1 |
| Kataoka, S | 1 |
| Ichikawa, D | 1 |
| Hamada, M | 1 |
| Taniguchi, R | 1 |
| Suzuki, K | 1 |
| Kawashima, N | 1 |
| Nishikawa, E | 1 |
| Narita, A | 1 |
| Okuno, Y | 2 |
| Nishio, N | 1 |
| Kato, K | 1 |
| Kojima, S | 1 |
| Morita, K | 1 |
| Muramatsu, H | 1 |
| Takahashi, Y | 1 |
| Yirgu, A | 1 |
| Mekonnen, Y | 1 |
| Eyado, A | 1 |
| Staropoli, A | 1 |
| Vinale, F | 1 |
| Zac, J | 1 |
| Zac, S | 1 |
| Pérez-Padilla, R | 1 |
| Remigio-Luna, A | 1 |
| Guzmán-Boulloud, N | 1 |
| Gochicoa-Rangel, L | 1 |
| Guzmán-Valderrábano, C | 1 |
| Thirión-Romero, I | 1 |
| Statsenko, ME | 1 |
| Turkina, SV | 1 |
| Barantsevich, ER | 1 |
| Karakulova, YV | 1 |
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| Morzhukhina, MV | 1 |
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| Li, J | 3 |
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| Davis, TME | 1 |
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| Davis, WA | 1 |
| Suzuki, Y | 2 |
| Mizuta, Y | 1 |
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| Misawa-Suzuki, T | 1 |
| Tsuchido, Y | 1 |
| Sugaya, T | 1 |
| Hashimoto, T | 2 |
| Ema, K | 1 |
| Hayashita, T | 1 |
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| Yamakawa, K | 1 |
| Nakano-Narusawa, Y | 1 |
| Kanie, S | 1 |
| Hashimoto, N | 1 |
| Saoo, K | 1 |
| Yokohira, M | 1 |
| Imaida, K | 1 |
| Matsuda, Y | 1 |
| Kondo, K | 1 |
| Yamada, N | 1 |
| Toyoda, K | 1 |
| Takahashi, T | 1 |
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| Kim, CH | 1 |
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| Park, TS | 1 |
| Son, HS | 1 |
| Cha, BY | 1 |
| Bagger, JI | 1 |
| Knop, FK | 1 |
| Lund, A | 1 |
| Vestergaard, H | 1 |
| Vilsbøll, T | 1 |
| Kapitza, C | 1 |
| Zdravkovic, M | 1 |
| Hindsberger, C | 1 |
| Flint, A | 1 |
| Tunnicliffe, JM | 1 |
| Eller, LK | 1 |
| Reimer, RA | 1 |
| Hittel, DS | 1 |
| Shearer, J | 1 |
| Kolterman, OG | 1 |
| Buse, JB | 1 |
| Fineman, MS | 2 |
| Gaines, E | 1 |
| Heintz, S | 1 |
| Bicsak, TA | 1 |
| Taylor, K | 1 |
| Kim, D | 1 |
| Aisporna, M | 1 |
| Baron, AD | 1 |
| Sawant, SP | 1 |
| Dnyanmote, AV | 1 |
| Mitra, MS | 1 |
| Chilakapati, J | 1 |
| Warbritton, A | 1 |
| Latendresse, JR | 1 |
| Mehendale, HM | 1 |
| Akhlaghi, F | 1 |
| Patel, CG | 1 |
| Zuniga, XP | 1 |
| Halilovic, J | 1 |
| Preis, IS | 1 |
| Gohh, RY | 1 |
| Johnson, J | 1 |
| Weinryb, J | 1 |
| Kellmeyer, TA | 1 |
| Kesty, NC | 1 |
| Frias, JP | 1 |
| Shertzer, HG | 1 |
| Schneider, SN | 1 |
| Kendig, EL | 1 |
| Clegg, DJ | 1 |
| D'Alessio, DA | 1 |
| Genter, MB | 1 |
| Gustafsson, UO | 1 |
| Nygren, J | 1 |
| Thorell, A | 1 |
| Soop, M | 1 |
| Hellström, PM | 1 |
| Ljungqvist, O | 1 |
| Hagström-Toft, E | 1 |
| Cervera, A | 1 |
| Wajcberg, E | 1 |
| Sriwijitkamol, A | 1 |
| Fernandez, M | 1 |
| Zuo, P | 1 |
| Triplitt, C | 1 |
| Musi, N | 1 |
| DeFronzo, RA | 1 |
| Cersosimo, E | 1 |
| Thomsen, C | 1 |
| Rasmussen, OW | 1 |
| Christiansen, C | 1 |
| Andreasen, F | 1 |
| Poulsen, PL | 1 |
| Kamali, F | 1 |
| Thomas, SH | 1 |
| Ferner, RE | 1 |
| Chan, MT | 1 |
| Anderson, PJ | 1 |
| Chan, JC | 1 |
| Lau, GS | 1 |
| Critchley, JA | 1 |
| Kawagishi, T | 1 |
| Nishizawa, Y | 1 |
| Taniwaki, H | 1 |
| Tanaka, S | 2 |
| Inaba, M | 1 |
| Ishimura, E | 1 |
| Emoto, M | 1 |
| Morii, H | 1 |
| Ranganath, L | 1 |
| Sedgwick, I | 1 |
| Morgan, L | 1 |
| Wright, J | 1 |
| Marks, V | 1 |
| Schwarz, A | 1 |
| Preuschof, L | 1 |
| Zellner, D | 1 |
| Iida, M | 1 |
| Ikeda, M | 1 |
| Kishimoto, M | 1 |
| Tsujino, T | 1 |
| Kaneto, H | 1 |
| Matsuhisa, M | 1 |
| Kajimoto, Y | 1 |
| Watarai, T | 1 |
| Yamasaki, Y | 1 |
| Hori, M | 1 |
| Kobayashi, T | 1 |
| Kawabata, M | 1 |
| Maehara, M | 1 |
| Mishima, A | 1 |
| Murase, T | 1 |
| Kaneko, T | 1 |
| Qin, LQ | 1 |
| Wang, PY | 1 |
| Sato, A | 1 |
| Bijlani, RL | 1 |
| Shukla, K | 1 |
| Narain, JP | 1 |
| Puri, P | 1 |
| Kasai, S | 1 |
| Tanaka, K | 1 |
| Machimura, H | 1 |
| Takeda, H | 1 |
| Kaneshige, H | 1 |
| Sakai, H | 1 |
| Harasawa, S | 1 |
| Adithan, C | 1 |
| Danda, D | 1 |
| Swaminathan, RP | 1 |
| Indhiresan, J | 1 |
| Shashindran, CH | 1 |
| Bapna, JS | 1 |
| Chandrasekar, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Clock Thickens: Morning or Evening Training for the Treatment of NAFLD? (TikTac Study)[NCT05987748] | 40 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| Quantification of the Incretin Effect in Healthy Subjects and Patients With Type 2 Diabetes Using Increasing Amounts of Oral Glucose Challenges[NCT00529048] | 16 participants (Actual) | Observational | 2007-10-31 | Completed | |||
| A Single Centre, Randomised, Double-blind, Placebo Controlled Trial to Evaluate the Possible Drug-drug Interaction Between Liraglutide and Paracetamol and the Effects of Liraglutide on Postprandial Glucose and Insulin, Gastric Emptying, Appetite Sensation[NCT01517555] | Phase 1 | 18 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
| Role of Exenatide in Treatment of NASH-a Pilot Study[NCT00650546] | Phase 2/Phase 3 | 8 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
| Effect of Preoperative Oral Carbohydrates on the Glycemic Variability of Diabetic Patients[NCT04013594] | 50 participants (Actual) | Interventional | 2019-08-20 | Completed | |||
| Do Preoperative Carbohydrate Drinks Prevent Preoperative Catabolism in Mothers Undergoing Elective Caesarean Section? A Randomised Controlled Study[NCT03220997] | 200 participants (Anticipated) | Interventional | 2017-08-31 | Not yet recruiting | |||
| The Effect of Carbohydrate Loading on Gastric Residual Volume and Hunger Score: A Single Blind, Randomised Controlled Trial Study[NCT03948594] | 78 participants (Anticipated) | Interventional | 2019-05-31 | Not yet recruiting | |||
| Impact of Preoperative Oral Carbohydrate on Recovery in Diabetic Patients After Gastrointestinal Surgery: a Pilot Randomized Controlled Trial[NCT03204344] | 65 participants (Actual) | Interventional | 2017-08-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The NAFLD Activity Score (NAS) is an underweight sum of steatosis (score 0-3), inflammation (score 0-3), ballooning scores (0-2). The NAS can range from 0-8 with the higher score indicating more aggressive disease. (NCT00650546)
Timeframe: Between baseline and 28 weeks of treatment with exenatide, sub q, 5-10 mcq.
| Intervention | units on a scale (Mean) |
|---|---|
| Individuals Who Recieved Treatment With Exenatide | -1.5 |
Number of patients with liver histology improved with exenatide. The improvement of liver histology was defined as (1) no worsening of the fibrosis score, (11) improved score by at least one point in hepatocyte ballooning, and (111) either (a) improvement in NAS (NAFLD Activity Score) by two points spread across as least two of the three NAS components, or by (B)post-treatment NAS<3. (NCT00650546)
Timeframe: between baseline and 24-28 weeks after initiating treatment
| Intervention | participants (Number) |
|---|---|
| Treatment With Exenatide | 8 |
2 reviews available for acetaminophen and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Black or African A | 2006 |
14 trials available for acetaminophen and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
Resistance to Acetaminophen Interference in a Novel Continuous Glucose Monitoring System.
Topics: Acetaminophen; Adolescent; Adult; Aged; Artifacts; Blood Glucose; Blood Glucose Self-Monitoring; Dia | 2018 |
Pre-Meal Effect of Whey Proteins on Metabolic Parameters in Subjects with and without Type 2 Diabetes: A Randomized, Crossover Trial.
Topics: Acetaminophen; Aged; Apolipoprotein B-48; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type | 2018 |
Transdermal Buprenorphine Relieves Neuropathic Pain: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial in Diabetic Peripheral Neuropathic Pain.
Topics: Acetaminophen; Administration, Cutaneous; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2016 |
Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy.
Topics: Acetaminophen; Adult; Aged; Amines; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Diabetes Mellit | 2010 |
The effect of the once-daily human glucagon-like peptide 1 analog liraglutide on the pharmacokinetics of acetaminophen.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Blood Glucose; Cross-Over Studies; | 2011 |
Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type | 2003 |
Pharmacokinetics of mycophenolic acid and metabolites in diabetic kidney transplant recipients.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Diabetes Mellitus, Type 1; Diabete | 2006 |
Pharmacokinetics of an oral drug (acetaminophen) administered at various times relative to subcutaneous injection of pramlintide in subjects with type 2 diabetes.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Amyloid; Analgesics, Non-Narcotic; Area Unde | 2007 |
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Beverages; Blood Glucose; Diabetes Mellitus, Type 2; | 2008 |
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Beverages; Blood Glucose; Diabetes Mellitus, Type 2; | 2008 |
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Beverages; Blood Glucose; Diabetes Mellitus, Type 2; | 2008 |
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Beverages; Blood Glucose; Diabetes Mellitus, Type 2; | 2008 |
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Beverages; Blood Glucose; Diabetes Mellitus, Type 2; | 2008 |
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Beverages; Blood Glucose; Diabetes Mellitus, Type 2; | 2008 |
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Beverages; Blood Glucose; Diabetes Mellitus, Type 2; | 2008 |
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Beverages; Blood Glucose; Diabetes Mellitus, Type 2; | 2008 |
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Beverages; Blood Glucose; Diabetes Mellitus, Type 2; | 2008 |
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Beverages; Blood Glucose; Diabetes Mellitus, Type 2; | 2008 |
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Beverages; Blood Glucose; Diabetes Mellitus, Type 2; | 2008 |
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Beverages; Blood Glucose; Diabetes Mellitus, Type 2; | 2008 |
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Beverages; Blood Glucose; Diabetes Mellitus, Type 2; | 2008 |
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Beverages; Blood Glucose; Diabetes Mellitus, Type 2; | 2008 |
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Beverages; Blood Glucose; Diabetes Mellitus, Type 2; | 2008 |
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Beverages; Blood Glucose; Diabetes Mellitus, Type 2; | 2008 |
The glycaemic index of spaghetti and gastric emptying in non-insulin-dependent diabetic patients.
Topics: Acetaminophen; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Female; Gastric Empt | 1994 |
Relationship between gastric emptying and an alpha-glucosidase inhibitor effect on postprandial hyperglycemia in NIDDM patients.
Topics: Acetaminophen; Blood Glucose; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Gastric Emptying | 1997 |
Evaluation of gut motility in type II diabetes by the radiopaque marker method.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Autonomic Nervous System; Colon; Cont | 2000 |
Effect of coingestion of paracetamol on glycaemic response.
Topics: Acetaminophen; Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Gastric Emptying; Huma | 1992 |
26 other studies available for acetaminophen and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Pilot study on the impact of a carbohydrate loading drink on postprandial glycemic responses and gastric emptying in adults with prediabetes and type 2 diabetes mellitus.
Topics: Acetaminophen; Adult; Blood Glucose; Diabetes Mellitus, Type 2; Diet, Carbohydrate Loading; Gastric | 2023 |
Population pharmacokinetic of paracetamol and atorvastatin with co-administration of semaglutide.
Topics: Acetaminophen; Atorvastatin; Diabetes Mellitus, Type 2; Glucagon-Like Peptide 1; Glucagon-Like Pepti | 2022 |
Diagnosis of drug-induced liver injury in model mice by studying the inhibitory effect of serum components on P450 inhibition assay.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome | 2022 |
Regular use of ibuprofen or paracetamol and incident type 2 diabetes: A prospective cohort study in the UK Biobank.
Topics: Acetaminophen; Adult; Biological Specimen Banks; Cardiovascular Diseases; Cohort Studies; Diabetes M | 2022 |
Preexisting diabetes mellitus had no effect on the no-observed-adverse-effect-level of acetaminophen in rats.
Topics: Acetaminophen; Animals; Diabetes Mellitus, Type 2; Hepatocytes; Hypertrophy; Male; No-Observed-Adver | 2020 |
Enhancement of acetaminophen-induced chronic hepatotoxicity in spontaneously diabetic torii (SDT) rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 2; Disease M | 2020 |
Scientific independence and objectivity: many questions linger about treatment of type 2 diabetes, such as scientific study design, optimal glucose control and the safety of injecting exogenous insulin.
Topics: Acetaminophen; Blood Glucose; Clinical Decision-Making; Diabetes Mellitus, Type 2; Endpoint Determin | 2020 |
Effects of mixed meal tolerance test on gastric emptying, glucose and lipid homeostasis in obese nonhuman primates.
Topics: Acetaminophen; Animal Feed; Animals; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Gastric Em | 2021 |
Kounis syndrome not induced but prevented by the implantation of a drug-eluting stent: a case report.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Diabetes Mellitus, Type 2; | 2017 |
Sweet syndrome induced by oral acetaminophen-codeine following repair of a facial fracture.
Topics: Acetaminophen; Adult; Codeine; Diabetes Mellitus, Type 2; Diagnosis, Differential; Drug Combinations | 2017 |
Protective effect of bark and empty pod extracts from Acacia auriculiformis against paracetamol intoxicated liver injury and alloxan induced type II diabetes.
Topics: Acacia; Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Alloxan; Animals; Aspartate Amino | 2013 |
Mixed meal ingestion diminishes glucose excursion in comparison with glucose ingestion via several adaptive mechanisms in people with and without type 2 diabetes.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Blood Glucose; C-Peptide; Case-Control Studies | 2016 |
[Stevens-Johnson syndrome plus intrahepatic cholestasis caused by clindamycin or chlorpheniramine].
Topics: Acetaminophen; Betamethasone; Bronchitis; Chlorpheniramine; Cholestasis, Intrahepatic; Clindamycin; | 2009 |
Impaired regulation of the incretin effect in patients with type 2 diabetes.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Area Under Curve; Blood Glucose; C-Peptide; Di | 2011 |
Chlorogenic acid differentially affects postprandial glucose and glucose-dependent insulinotropic polypeptide response in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blood Glucose; Cell Line; Chlorogenic Acid; Coffee | 2011 |
Protective effect of type 2 diabetes on acetaminophen-induced hepatotoxicity in male Swiss-Webster mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Chromatogr | 2006 |
Acetaminophen normalizes glucose homeostasis in mouse models for diabetes.
Topics: Acetaminophen; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; D | 2008 |
Mechanism of action of exenatide to reduce postprandial hyperglycemia in type 2 diabetes.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Blood Glucose; Diabetes Mellitus, Type 2; Exenatide; | 2008 |
Paracetamol elimination in patients with non-insulin dependent diabetes mellitus.
Topics: Acetaminophen; Aged; Diabetes Mellitus, Type 2; Female; Humans; Kidney; Male; Metabolic Clearance Ra | 1993 |
Single-dose pharmacokinetics of paracetamol and its conjugates in Chinese non-insulin-dependent diabetic patients with renal impairment.
Topics: Acetaminophen; Adult; Aged; Area Under Curve; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Fem | 1997 |
The ageing entero-insular axis.
Topics: Acetaminophen; Adult; Aged; Aging; Blood Glucose; Body Mass Index; Body Weight; Diabetes Mellitus, T | 1998 |
Incidence of analgesic nephropathy in Berlin since 1983.
Topics: Acetaminophen; Age Factors; Aged; Analgesics; Berlin; Diabetes Mellitus, Type 1; Diabetes Mellitus, | 1999 |
Methemoglobinemia induced by combined use of sodium nitrate and acetoaminophen.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Arthritis, Rheumatoid; Diabetes Mellitus, Type 2; Dru | 2000 |
Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Carbon Tetrachloride; C | 2002 |
Effect of cisapride on gastric emptying in diabetic patients without gastrointestinal symptoms.
Topics: Acetaminophen; Blood Glucose; Cisapride; Diabetes Mellitus, Type 2; Female; Gastric Emptying; Glucos | 1991 |
Effect of diabetes mellitus on salivary paracetamol elimination.
Topics: Acetaminophen; Adolescent; Adult; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabe | 1988 |