acetaminophen has been researched along with Dementia in 24 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine in a sample of nursing home patients with dementia and a painful condition whether the regularly scheduled administration of acetaminophen (650 mg four times a day (qid)) was more or less effective than as-needed (prn) administration of acetaminophen in reducing discomfort." | 9.11 | A clinical trial of the effectiveness of regularly scheduled versus as-needed administration of acetaminophen in the management of discomfort in older adults with dementia. ( Brod, M; Buffum, MD; Miaskowski, C; Sands, L; Washburn, A, 2004) |
| "The objectives of this study are to determine the effects of regularly scheduled administration of paracetamol (acetaminophen) on quality of life (QoL), discomfort, pain and neuropsychiatric symptoms of persons with dementia living in long-term care facilities (LTCFs)." | 5.34 | Does paracetamol improve quality of life, discomfort, pain and neuropsychiatric symptoms in persons with advanced dementia living in long-term care facilities? A randomised double-blind placebo-controlled crossover (Q-PID) trial. ( Achterberg, WP; Caljouw, MAA; Husebo, BS; van Dam, PH, 2020) |
| " Patients received stepwise pain treatment in which those who did not use analgesics were randomized to receive either paracetamol (3 g/day) or placebo tablets; those who already used pain treatment were allocated to buprenorphine transdermal system (max." | 5.27 | Effects of pain treatment on sleep in nursing home patients with dementia and depression: A multicenter placebo-controlled randomized clinical trial. ( Bjorvatn, B; Blytt, KM; Flo, E; Husebo, B, 2018) |
| "Analgesic treatment did not reduce depression while placebo appeared to improve depressive symptoms significantly by comparison, possibly owing to the adverse effects of active buprenorphine." | 5.27 | Efficacy and Safety of Analgesic Treatment for Depression in People with Advanced Dementia: Randomised, Multicentre, Double-Blind, Placebo-Controlled Trial (DEP.PAIN.DEM). ( Aarsland, D; Ballard, C; Erdal, A; Flo, E; Husebo, BS; Slettebo, DD, 2018) |
| " According to a predefined scheme for 8 weeks, all patients in the intervention group received individual daily pain treatment with acetaminophen, extended release morphine, buprenorphine transdermal patch, and/or pregabaline." | 5.19 | The response of agitated behavior to pain management in persons with dementia. ( Aarsland, D; Ballard, C; Cohen-Mansfield, J; Husebo, BS; Seifert, R, 2014) |
| "Pain medication significantly improved pain in the intervention group, with indications that acetaminophen also improved ADL function." | 5.19 | Impact of a stepwise protocol for treating pain on pain intensity in nursing home patients with dementia: a cluster randomized trial. ( Aarsland, D; Ballard, C; Corbett, A; Husebo, BS; Sandvik, RK; Seifert, R; Selbaek, G, 2014) |
| "To determine in a sample of nursing home patients with dementia and a painful condition whether the regularly scheduled administration of acetaminophen (650 mg four times a day (qid)) was more or less effective than as-needed (prn) administration of acetaminophen in reducing discomfort." | 5.11 | A clinical trial of the effectiveness of regularly scheduled versus as-needed administration of acetaminophen in the management of discomfort in older adults with dementia. ( Brod, M; Buffum, MD; Miaskowski, C; Sands, L; Washburn, A, 2004) |
| "With respect to analgesics use, we employed data from national registries on the analgesic prescription use (opioids, nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen) in 2017 among elderly people with and without dementia." | 5.01 | Analgesics use and withdrawal in people with dementia - a register-based Danish study and a systematic review. ( Bandak, E; Christensen, MB; Johannsen, P; Kallehauge, H; Lolk, A; Pedersen, H; Saxtrup, N; Solem, EJ; Sørensen, AMS; Tarp, S, 2019) |
| "Un(der)diagnosed and un(der)treated pain is a serious and frequent problem in persons with dementia." | 2.87 | Quality of life and paracetamol in advanced dementia (Q-PID): protocol of a randomised double-blind placebo-controlled crossover trial. ( Achterberg, WP; Caljouw, MAA; Gussekloo, J; Husebo, BS; van Dam, PH, 2018) |
| "Pain was more commonly reported by informal caregivers than the person with dementia themselves." | 2.61 | Pain assessment and pain treatment for community-dwelling people with dementia: A systematic review and narrative synthesis. ( Bartlam, B; Bedson, J; Bullock, L; Campbell, P; Chew-Graham, CA; Jordan, JL, 2019) |
| "Pain was assessed using the Mobilization-Observation-Behavior-Intensity-Dementia-2 (MOBID-2) Pain Scale." | 1.72 | Prevalence and persistent prescription of analgesic drugs in persons admitted with dementia to a nursing home - A longitudinal study. ( Bergh, S; Helvik, AS; Husebø, B; Kabukcuoğlu, K; Lichtwarck, B; Šaltytė Benth, J; Tevik, K, 2022) |
| "Registered nurses (RNs) play a pivotal role in treating pain and preventing and recognizing the adverse effects (AEs) of analgesics in patients with dementia." | 1.42 | Registered Nurses' Knowledge about Adverse Effects of Analgesics when Treating Postoperative Pain in Patients with Dementia. ( Hartikainen, S; Kankkunen, P; Kvist, T; Rantala, M, 2015) |
| "Although daytime sleepiness occurred in a large number of residents, especially those with dementia, this sleepiness was not necessarily associated with use of opioids." | 1.42 | Analgesic Use and Daytime Sleepiness in Residents With and Without Dementia in Residential Aged Care Facilities. ( Bell, JS; Emery, T; Hilmer, SN; Hughes, JM; Ilomäki, J; Jones, MJ; Moawad, S; Quirke, T; Robson, L; Tan, EC; Visvanathan, R; Vitry, AI, 2015) |
| "Nurses play a pivotal role in treating postoperative pain in patients with dementia and monitoring the effects of administered analgesics." | 1.40 | Analgesics in postoperative care in hip fracture patients with dementia - reported by nurses. ( Hartikainen, S; Kankkunen, P; Kvist, T; Rantala, M, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 14 (58.33) | 24.3611 |
| 2020's | 6 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schuler, M | 1 |
| Helvik, AS | 3 |
| Bergh, S | 3 |
| Kabukcuoğlu, K | 1 |
| Šaltytė Benth, J | 3 |
| Lichtwarck, B | 1 |
| Husebø, B | 2 |
| Tevik, K | 3 |
| Resnick, B | 1 |
| Boltz, M | 1 |
| Galik, E | 1 |
| Ellis, J | 1 |
| Kuzmik, A | 1 |
| Drazich, B | 1 |
| McPherson, R | 1 |
| Kim, E | 1 |
| Borza, T | 1 |
| Sørensen, AMS | 1 |
| Tarp, S | 1 |
| Johannsen, P | 1 |
| Lolk, A | 1 |
| Bandak, E | 1 |
| Pedersen, H | 1 |
| Saxtrup, N | 1 |
| Kallehauge, H | 1 |
| Solem, EJ | 1 |
| Christensen, MB | 1 |
| van Dam, PH | 2 |
| Achterberg, WP | 2 |
| Husebo, BS | 7 |
| Caljouw, MAA | 2 |
| Selbaek, G | 3 |
| Tung, EE | 1 |
| Litin, SC | 1 |
| Bundrick, JB | 1 |
| Blytt, KM | 1 |
| Bjorvatn, B | 1 |
| Husebo, B | 1 |
| Flo, E | 2 |
| Erdal, A | 1 |
| Aarsland, D | 4 |
| Ballard, C | 3 |
| Slettebo, DD | 1 |
| Gussekloo, J | 1 |
| Bullock, L | 1 |
| Bedson, J | 1 |
| Jordan, JL | 1 |
| Bartlam, B | 1 |
| Chew-Graham, CA | 1 |
| Campbell, P | 1 |
| Cohen-Mansfield, J | 1 |
| Seifert, R | 2 |
| Rantala, M | 2 |
| Hartikainen, S | 2 |
| Kvist, T | 2 |
| Kankkunen, P | 2 |
| Sandvik, RK | 1 |
| Corbett, A | 1 |
| Breivik, H | 1 |
| Tan, EC | 1 |
| Visvanathan, R | 1 |
| Hilmer, SN | 1 |
| Emery, T | 1 |
| Robson, L | 1 |
| Vitry, AI | 1 |
| Hughes, JM | 1 |
| Jones, MJ | 1 |
| Moawad, S | 1 |
| Ilomäki, J | 1 |
| Quirke, T | 1 |
| Bell, JS | 1 |
| Sandvik, R | 1 |
| Kirkevold, O | 1 |
| Jensen-Dahm, C | 1 |
| Palm, H | 1 |
| Gasse, C | 1 |
| Dahl, JB | 1 |
| Waldemar, G | 1 |
| Balfour, JE | 1 |
| O'Rourke, N | 1 |
| Buffum, MD | 1 |
| Sands, L | 1 |
| Miaskowski, C | 1 |
| Brod, M | 1 |
| Washburn, A | 1 |
| Nygaard, HA | 1 |
| Jarland, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Pain Treatment on Depression in Patients With Dementia. A Randomized Clinical Trial.[NCT02267057] | Phase 4 | 163 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| The Impact of Pain on Behavioural Disturbances in Patients With Moderate and Severe Dementia. A Cluster Randomized Trial[NCT01021696] | Phase 2/Phase 3 | 352 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for acetaminophen and Dementia
| Article | Year |
|---|---|
Analgesics use and withdrawal in people with dementia - a register-based Danish study and a systematic review.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammat | 2019 |
Pain assessment and pain treatment for community-dwelling people with dementia: A systematic review and narrative synthesis.
Topics: Acetaminophen; Analgesia; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Dementia; Humans | 2019 |
7 trials available for acetaminophen and Dementia
| Article | Year |
|---|---|
Does paracetamol improve quality of life, discomfort, pain and neuropsychiatric symptoms in persons with advanced dementia living in long-term care facilities? A randomised double-blind placebo-controlled crossover (Q-PID) trial.
Topics: Acetaminophen; Aged; Aged, 80 and over; Cross-Over Studies; Dementia; Disease Progression; Double-Bl | 2020 |
Effects of pain treatment on sleep in nursing home patients with dementia and depression: A multicenter placebo-controlled randomized clinical trial.
Topics: Acetaminophen; Adult; Aged; Analgesics; Buprenorphine; Dementia; Depressive Disorder; Double-Blind M | 2018 |
Efficacy and Safety of Analgesic Treatment for Depression in People with Advanced Dementia: Randomised, Multicentre, Double-Blind, Placebo-Controlled Trial (DEP.PAIN.DEM).
Topics: Acetaminophen; Administration, Cutaneous; Aged, 80 and over; Analgesics; Buprenorphine; Chronic Pain | 2018 |
Quality of life and paracetamol in advanced dementia (Q-PID): protocol of a randomised double-blind placebo-controlled crossover trial.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Cross-Over Studies; Dementia; Depression; Double-Blin | 2018 |
The response of agitated behavior to pain management in persons with dementia.
Topics: Acetaminophen; Aged, 80 and over; Analgesics; Buprenorphine; Delayed-Action Preparations; Dementia; | 2014 |
Impact of a stepwise protocol for treating pain on pain intensity in nursing home patients with dementia: a cluster randomized trial.
Topics: Acetaminophen; Activities of Daily Living; Aged; Aged, 80 and over; Analgesics; Buprenorphine; Clini | 2014 |
A clinical trial of the effectiveness of regularly scheduled versus as-needed administration of acetaminophen in the management of discomfort in older adults with dementia.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Cross-Over Studies; Dementia; Doub | 2004 |
15 other studies available for acetaminophen and Dementia
| Article | Year |
|---|---|
[Pain and dementia: what to consider?]
Topics: Acetaminophen; Cognition; Dementia; Humans; Pain; Pain Management | 2021 |
Prevalence and persistent prescription of analgesic drugs in persons admitted with dementia to a nursing home - A longitudinal study.
Topics: Acetaminophen; Activities of Daily Living; Aged, 80 and over; Analgesics; Analgesics, Opioid; Dement | 2022 |
A Descriptive Study of Treatment of Pain in Acute Care for Patients Living With Dementia.
Topics: Acetaminophen; Dementia; Female; Humans; Pain; Pain Management; Tramadol | 2023 |
Pain and quality of life in nursing home residents with dementia after admission - a longitudinal study.
Topics: Acetaminophen; Activities of Daily Living; Aged, 80 and over; Analgesics, Opioid; Dementia; Female; | 2023 |
Pain in nursing home residents with dementia and its association to quality of life.
Topics: Acetaminophen; Activities of Daily Living; Aged, 80 and over; Cross-Sectional Studies; Dementia; Fem | 2022 |
Clinical Pearls in Geriatrics.
Topics: Acetaminophen; Aged; Aged, 80 and over; Automobile Driving; Cognition Disorders; Cognitive Dysfuncti | 2017 |
Analgesics in postoperative care in hip fracture patients with dementia - reported by nurses.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Attitude of Health Pe | 2014 |
A high-quality RCT documents that elderly with dementia, the most neglected pain patients, have effective and safe pain relief from paracetamol alone or with buprenorphine patch.
Topics: Acetaminophen; Analgesics; Buprenorphine; Clinical Protocols; Dementia; Female; gamma-Aminobutyric A | 2014 |
Registered Nurses' Knowledge about Adverse Effects of Analgesics when Treating Postoperative Pain in Patients with Dementia.
Topics: Acetaminophen; Adult; Age Factors; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste | 2015 |
Analgesic Use and Daytime Sleepiness in Residents With and Without Dementia in Residential Aged Care Facilities.
Topics: Acetaminophen; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ster | 2015 |
Analgesic prescribing patterns in Norwegian nursing homes from 2000 to 2011: trend analyses of four data samples.
Topics: Acetaminophen; Age Factors; Aged; Aged, 80 and over; Aging; Analgesics; Analgesics, Non-Narcotic; An | 2016 |
Postoperative Treatment of Pain after Hip Fracture in Elderly Patients with Dementia.
Topics: Acetaminophen; Administration, Oral; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Dement | 2016 |
Older adults with Alzheimer disease, comorbid arthritis and prescription of psychotropic medications.
Topics: Acetaminophen; Aged; Aged, 80 and over; Alzheimer Disease; Analgesics; Arthritis; Benzodiazepines; C | 2003 |
Are nursing home patients with dementia diagnosis at increased risk for inadequate pain treatment?
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Analgesics, Non-Narcotic; Cognition Disorders; C | 2005 |
Common pain reliever may promote social interaction in people with dementia.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Dementia; Humans; Interpersonal Relations; Pain | 2006 |