acetaminophen has been researched along with Critical Illness in 64 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In adults with severe sepsis and detectable plasma cell-free hemoglobin, treatment with acetaminophen within 24 hours of ICU admission may reduce oxidative injury and improve renal function." | 9.20 | Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial. ( Bastarache, JA; Bernard, GR; Janz, DR; Oates, JA; Rice, TW; Roberts, LJ; Sills, G; Ware, LB; Warren, MA; Wickersham, N, 2015) |
| "Acetaminophen is a common therapy for fever in patients in the intensive care unit (ICU) who have probable infection, but its effects are unknown." | 9.20 | Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. ( Beasley, R; Bellomo, R; Freebairn, R; Hammond, N; Henderson, S; Holliday, M; Mackle, D; McArthur, C; McGuinness, S; Myburgh, J; Saxena, M; van Haren, F; Weatherall, M; Webb, S; Young, P, 2015) |
| "Acetaminophen (APAP) has been shown to inhibit lipid peroxidation and, thus, may be renal protective in patients with sepsis." | 5.48 | Effect of Acetaminophen on the Prevention of Acute Kidney Injury in Patients With Sepsis. ( Aljuhani, O; Bakhsh, H; Erstad, BL; Patanwala, AE, 2018) |
| " IV and PO APAP doses administered with a predose pain score ≥4 within 1 h of dosing were compared." | 5.43 | Intravenous Versus Oral Acetaminophen for Pain Control in Neurocritical Care Patients. ( Brophy, GM; Nadpara, PA; Nichols, DC; Taylor, PD, 2016) |
| "In May and June 2020, an open-date literature search of English publications indexed in ProQuest, PubMed, and EBSCO was conducted with the search terms 'acetaminophen' and 'hypotension' and related search combinations ('paracetamol', 'propacetamol', 'low blood pressure', 'fever', 'sepsis', and 'shock') to identify peer-reviewed publications of blood pressure changes after paracetamol administration in humans." | 5.22 | A narrative review of paracetamol-induced hypotension: Keeping the patient safe. ( Young, TL, 2022) |
| "In adults with severe sepsis and detectable plasma cell-free hemoglobin, treatment with acetaminophen within 24 hours of ICU admission may reduce oxidative injury and improve renal function." | 5.20 | Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial. ( Bastarache, JA; Bernard, GR; Janz, DR; Oates, JA; Rice, TW; Roberts, LJ; Sills, G; Ware, LB; Warren, MA; Wickersham, N, 2015) |
| "Acetaminophen is a common therapy for fever in patients in the intensive care unit (ICU) who have probable infection, but its effects are unknown." | 5.20 | Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. ( Beasley, R; Bellomo, R; Freebairn, R; Hammond, N; Henderson, S; Holliday, M; Mackle, D; McArthur, C; McGuinness, S; Myburgh, J; Saxena, M; van Haren, F; Weatherall, M; Webb, S; Young, P, 2015) |
| "To compare the antipyretic and hemodynamic effects of metamizol and propacetamol in critically ill patients with fever." | 5.10 | [Metamizol versus propacetamol: comparative study of the hemodynamic and antipyretic effects in critically ill patients]. ( Cruz, P; Díaz, S; Fernández-Quero, L; Garutti, I, 2002) |
| "Literature searches were performed using keywords: "paracetamol", "acetaminophen", "critical illness", "intensive care", "history", "pharmacology", "antipyre*", "analgesi*", "adverse effect*", "administration and dosage", "toxicity", "animals" and "humans"." | 4.88 | Paracetamol in critical illness: a review. ( Jefferies, S; Saxena, M; Young, P, 2012) |
| "All children who received acetaminophen or had a fever (temperature ≥ 38°C) while on the ICU over a 40-month period (September 2012 to December 2015)." | 3.88 | The Effect of Acetaminophen on Temperature in Critically Ill Children: A Retrospective Analysis of Over 50,000 Doses. ( Brown, KL; Peters, MJ; Ray, S; Rogers, L, 2018) |
| "We sought to assess the incidence of acetaminophen-induced hypotension." | 3.83 | Acetaminophen-Induced Changes in Systemic Blood Pressure in Critically Ill Patients: Results of a Multicenter Cohort Study. ( Abroug, F; Balichard, S; Bornstain, C; Cantais, A; Darmon, M; Hammouda, Z; Meziani, F; Perinel, S; Schnell, D; Vincent, F; Zeni, F, 2016) |
| "Admission M30 levels were significantly elevated in acetaminophen-induced acute liver failure and non-acetaminophen induced acute liver failure patients compared with multiple organ failure, chronic liver disease, and healthy controls." | 3.79 | Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*. ( Abeles, RD; Antoniades, CG; Bernal, W; Dharwan, A; Heaton, ND; Hughes, RD; Jassem, W; Karvellas, CJ; Leslie, EM; Ma, Y; McPhail, MJ; Mitry, RR; Possamai, LA; Puthucheary, Z; Quaglia, A; Rawal, J; Shawcross, DL; Thursz, M; Tidswell, R; Wendon, JA; Zingarelli, V, 2013) |
| "To elucidate the mechanism of hypotension following intravenous administration of paracetamol (acetaminophen) to patients on the Intensive Care Unit." | 3.79 | Mechanism of paracetamol-induced hypotension in critically ill patients: a prospective observational cross-over study. ( Duška, F; Krajčová, A; Matoušek, V, 2013) |
| " Acetaminophen was administered for 88 of 166 fevers." | 3.76 | Acetaminophen has limited antipyretic activity in critically ill patients. ( Chen, H; Greenberg, RS; Hasday, JD, 2010) |
| "To investigate the effect of intravenous propacetamol, a parenteral bioprecursor of acetaminophen, on systemic blood pressure in critically ill patients with fever, and to establish the prevalence and clinical significance of this effect." | 3.74 | Effect of intravenous propacetamol on blood pressure in febrile critically ill patients. ( Hersch, M; Izbicki, G; Raveh, D, 2008) |
| " Laboratory evaluation revealed a high anion gap metabolic acidosis and modestly elevated acetaminophen level." | 3.74 | Profound metabolic acidosis and oxoprolinuria in an adult. ( Cantor, R; Carmel, PM; Hodgman, MJ; Holland, MG; Horn, JF; Marraffa, JM; Stork, CM, 2007) |
| " The mean age, weight and area under the concentration-time curve for the sampled dosing interval were 34." | 2.87 | Population pharmacokinetics of intravenous paracetamol in critically ill patients with traumatic brain injury. ( Gowardman, J; Lipman, J; Myburgh, J; Parker, SL; Roberts, JA; Saxena, M, 2018) |
| "The pharmacokinetic profile of intravenous acetaminophen administered to critically ill multiple-trauma patients was studied after 4 consecutive doses of 1 g every 6 hours." | 2.84 | Pharmacokinetic Study of Intravenous Acetaminophen Administered to Critically Ill Multiple-Trauma Patients at the Usual Dosage and a New Proposal for Administration. ( Fuster-Lluch, O; Gerónimo-Pardo, M; Zapater-Hernández, P, 2017) |
| "To assess the safety and feasibility of treating critically ill adults with different fever control strategies." | 2.78 | Assessment of the safety and feasibility of administering antipyretic therapy in critically ill adults: a pilot randomized clinical trial. ( Kubes, P; Laupland, KB; Léger, C; Niven, DJ; Stelfox, HT, 2013) |
| "Aggressively treating fever in critically ill patients may lead to a higher mortality rate." | 2.71 | The effect of antipyretic therapy upon outcomes in critically ill patients: a randomized, prospective study. ( Alhaddad, A; Amortegui, J; Baracco, G; Cohn, SM; Dlugasch, L; Doherty, J; Dy, CJ; Elhaddad, A; Lasko, D; Li, P; Manning, RJ; Namias, N; Schulman, CI, 2005) |
| "Although fever is a host defense response that may benefit some critically ill patients, others may not tolerate the cardiovascular demands associated with fever." | 2.70 | Comparison of fever treatments in the critically ill: a pilot study. ( Henker, R; Kelso, L; Kerr, M; Kramer, DJ; Rogers, S; Sereika, S, 2001) |
| "Induction of fever is mediated by the release of pyrogenic cytokines (tumor necrosis factor α, interleukin 1, interleukin 6, and interferons)." | 2.55 | Paracetamol in fever in critically ill patients-an update. ( Chiumello, D; Gotti, M; Vergani, G, 2017) |
| "Acetaminophen (paracetamol) is a ubiquitously administered drug in critically ill patients." | 1.91 | Population Pharmacokinetic Modeling and Dose Optimization of Acetaminophen and its Metabolites Following Intravenous Infusion in Critically ill Adults. ( Mulubwa, M; Qader, AM; Sridharan, K, 2023) |
| "• Acetaminophen dosing errors are common in pediatric outpatients." | 1.72 | Liver enzymes after short-term acetaminophen error in critically ill children: a cohort study. ( Parshuram, C; Pullenayegum, E; Rochon, P; Roumeliotis, N; Taddio, A, 2022) |
| " Dosing regimens of frusemide, and acetaminophen, and the sizes of ductus arteriosus following treatment, were evaluated." | 1.62 | Intravenous frusemide does not interact pharmacodynamically with acetaminophen in critically ill preterm neonates with patent ductus arteriosus. ( Al Ansari, E; Al Jufairi, M; Al Madhoob, A; Al Marzooq, R; Sridharan, K, 2021) |
| "8-20 mo) the mean enteral bioavailability was 72% (range, 11-91%)." | 1.51 | Enteral Acetaminophen Bioavailability in Pediatric Intensive Care Patients Determined With an Oral Microtracer and Pharmacokinetic Modeling to Optimize Dosing. ( Calvier, E; de Wildt, SN; Kleiber, N; Knibbe, CAJ; Krekels, EHJ; Mooij, MG; Tibboel, D; Vaes, WHJ, 2019) |
| "Acetaminophen (APAP) has been shown to inhibit lipid peroxidation and, thus, may be renal protective in patients with sepsis." | 1.48 | Effect of Acetaminophen on the Prevention of Acute Kidney Injury in Patients With Sepsis. ( Aljuhani, O; Bakhsh, H; Erstad, BL; Patanwala, AE, 2018) |
| "Routine oral dosing practices in a SSA hospital resulted in substantial underexposure to paracetamol." | 1.46 | Paracetamol clinical dosing routine leads to paracetamol underexposure in an adult severely ill sub-Saharan African hospital population: a drug concentration measurement study. ( Bos, JC; Mathôt, RAA; Mistício, MC; Nunguiane, G; Prins, JM; van Hest, RM, 2017) |
| " IV and PO APAP doses administered with a predose pain score ≥4 within 1 h of dosing were compared." | 1.43 | Intravenous Versus Oral Acetaminophen for Pain Control in Neurocritical Care Patients. ( Brophy, GM; Nadpara, PA; Nichols, DC; Taylor, PD, 2016) |
| "Fever is one of the most commonly observed abnormal signs in patients with critical illness." | 1.38 | Assessment of the safety and feasibility of administering anti-pyretic therapy in critically ill adults: study protocol of a randomized trial. ( Kubes, P; Laupland, KB; Léger, C; Niven, DJ; Stelfox, HT, 2012) |
| "Dexketoprofen was the most effective antipyretic agent at the doses tested." | 1.38 | [Hemodynamic and antipyretic effects of paracetamol, metamizol and dexketoprofen in critical patients]. ( Betbesé, AJ; Gich, I; Mancebo, J; Vera, P; Zapata, L, 2012) |
| "To develop a semi-mechanistic population pharmacokinetic model based on gastric emptying function for acetaminophen plasma concentration in critically ill patients tolerant and intolerant to enteral nutrition before and after prokinetic therapy." | 1.37 | A semi-mechanistic gastric emptying model for the population pharmacokinetic analysis of orally administered acetaminophen in critically ill patients. ( Aarons, L; Dukes, G; Maclaren, R; Ogungbenro, K; Vasist, L; Young, M, 2011) |
| "Most glucose meter comparisons to date have focused on performance specifications likely to impact subcutaneous dosing of insulin." | 1.35 | Evaluation of the impact of hematocrit and other interference on the accuracy of hospital-based glucose meters. ( Bryant, SC; Dubois, JA; Griesmann, L; Karon, BS; Presti, S; Santrach, PJ; Scott, R; Shirey, TL, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (9.38) | 18.2507 |
| 2000's | 11 (17.19) | 29.6817 |
| 2010's | 38 (59.38) | 24.3611 |
| 2020's | 9 (14.06) | 2.80 |
| Authors | Studies |
|---|---|
| Roumeliotis, N | 2 |
| Frndova, H | 1 |
| Pullenayegum, E | 2 |
| Taddio, A | 2 |
| Rochon, P | 2 |
| Parshuram, CS | 1 |
| Gillmann, HJ | 1 |
| Reichart, J | 1 |
| Leffler, A | 2 |
| Stueber, T | 1 |
| Parshuram, C | 1 |
| Baldia, PH | 1 |
| Wernly, B | 1 |
| Flaatten, H | 1 |
| Fjølner, J | 1 |
| Artigas, A | 1 |
| Pinto, BB | 1 |
| Schefold, JC | 1 |
| Kelm, M | 1 |
| Beil, M | 1 |
| Bruno, RR | 1 |
| Binnebößel, S | 1 |
| Wolff, G | 1 |
| Erkens, R | 1 |
| Sigal, S | 1 |
| van Heerden, PV | 1 |
| Szczeklik, W | 1 |
| Elhadi, M | 1 |
| Joannidis, M | 1 |
| Oeyen, S | 1 |
| Marsh, B | 1 |
| Andersen, FH | 1 |
| Moreno, R | 1 |
| Leaver, S | 1 |
| De Lange, DW | 1 |
| Guidet, B | 1 |
| Jung, C | 1 |
| Belicard, F | 1 |
| Pinceaux, K | 1 |
| Le Pabic, E | 1 |
| Coirier, V | 1 |
| Delamaire, F | 1 |
| Painvin, B | 1 |
| Lesouhaitier, M | 1 |
| Maamar, A | 1 |
| Guillot, P | 1 |
| Quelven, Q | 1 |
| Houssel, P | 1 |
| Boudjema, K | 1 |
| Reizine, F | 1 |
| Camus, C | 1 |
| Sridharan, K | 2 |
| Mulubwa, M | 1 |
| Qader, AM | 1 |
| Moffett, BS | 2 |
| Gutierrez, K | 1 |
| Davis, K | 1 |
| Sigdel, B | 1 |
| Strobel, N | 1 |
| Kleiber, N | 1 |
| Calvier, E | 1 |
| Mooij, MG | 1 |
| Krekels, EHJ | 1 |
| Vaes, WHJ | 1 |
| Tibboel, D | 2 |
| Knibbe, CAJ | 1 |
| de Wildt, SN | 1 |
| Al Madhoob, A | 1 |
| Al Jufairi, M | 1 |
| Al Ansari, E | 1 |
| Al Marzooq, R | 1 |
| Southren, DL | 1 |
| Nardone, AD | 1 |
| Haastrup, AA | 1 |
| Roberts, RJ | 1 |
| Chang, MG | 1 |
| Bittner, EA | 1 |
| Young, TL | 1 |
| Schell-Chaple, HM | 1 |
| Liu, KD | 1 |
| Matthay, MA | 1 |
| Sessler, DI | 1 |
| Puntillo, KA | 1 |
| Simon, A | 1 |
| Ray, S | 2 |
| Brick, T | 1 |
| Raman, S | 1 |
| Birrell, PJ | 1 |
| Klein, NJ | 1 |
| Peters, MJ | 2 |
| Fuster-Lluch, O | 1 |
| Zapater-Hernández, P | 1 |
| Gerónimo-Pardo, M | 1 |
| Patanwala, AE | 1 |
| Aljuhani, O | 1 |
| Bakhsh, H | 1 |
| Erstad, BL | 1 |
| Mian, P | 1 |
| Morlion, B | 1 |
| Allegaert, K | 1 |
| Bos, JC | 1 |
| Mistício, MC | 1 |
| Nunguiane, G | 1 |
| Mathôt, RAA | 1 |
| van Hest, RM | 1 |
| Prins, JM | 1 |
| Rogers, L | 1 |
| Brown, KL | 1 |
| Parker, SL | 1 |
| Saxena, M | 4 |
| Gowardman, J | 1 |
| Lipman, J | 1 |
| Myburgh, J | 3 |
| Roberts, JA | 1 |
| Achuff, BJ | 1 |
| Acosta, S | 1 |
| Lasa, JJ | 1 |
| Checchia, PA | 1 |
| Rusin, CG | 1 |
| Wampole, CR | 1 |
| Smith, KE | 1 |
| Maxwell, EN | 1 |
| Johnson, B | 1 |
| Cammilleri, J | 1 |
| Ferreira, JA | 1 |
| Payen, JF | 1 |
| Genty, C | 1 |
| Mimoz, O | 1 |
| Mantz, J | 1 |
| Bosson, JL | 1 |
| Chanques, G | 1 |
| Possamai, LA | 1 |
| McPhail, MJ | 1 |
| Quaglia, A | 1 |
| Zingarelli, V | 1 |
| Abeles, RD | 1 |
| Tidswell, R | 1 |
| Puthucheary, Z | 1 |
| Rawal, J | 1 |
| Karvellas, CJ | 1 |
| Leslie, EM | 1 |
| Hughes, RD | 1 |
| Ma, Y | 1 |
| Jassem, W | 1 |
| Shawcross, DL | 1 |
| Bernal, W | 1 |
| Dharwan, A | 1 |
| Heaton, ND | 1 |
| Thursz, M | 1 |
| Wendon, JA | 1 |
| Mitry, RR | 1 |
| Antoniades, CG | 1 |
| McGill, MR | 1 |
| Jaeschke, H | 1 |
| Janz, DR | 1 |
| Bastarache, JA | 1 |
| Rice, TW | 1 |
| Bernard, GR | 1 |
| Warren, MA | 1 |
| Wickersham, N | 1 |
| Sills, G | 1 |
| Oates, JA | 1 |
| Roberts, LJ | 1 |
| Ware, LB | 1 |
| Kar, P | 1 |
| Jones, KL | 1 |
| Horowitz, M | 1 |
| Chapman, MJ | 1 |
| Deane, AM | 1 |
| Suzuki, S | 1 |
| Eastwood, GM | 2 |
| Bailey, M | 2 |
| Gattas, D | 1 |
| Kruger, P | 1 |
| Santamaria, JD | 1 |
| Bellomo, R | 4 |
| Young, P | 3 |
| Freebairn, R | 1 |
| Hammond, N | 1 |
| van Haren, F | 1 |
| Holliday, M | 1 |
| Henderson, S | 1 |
| Mackle, D | 1 |
| McArthur, C | 1 |
| McGuinness, S | 1 |
| Weatherall, M | 1 |
| Webb, S | 1 |
| Beasley, R | 1 |
| Nichols, DC | 1 |
| Nadpara, PA | 1 |
| Taylor, PD | 1 |
| Brophy, GM | 1 |
| Cantais, A | 1 |
| Schnell, D | 1 |
| Vincent, F | 1 |
| Hammouda, Z | 1 |
| Perinel, S | 1 |
| Balichard, S | 1 |
| Abroug, F | 1 |
| Zeni, F | 1 |
| Meziani, F | 1 |
| Bornstain, C | 1 |
| Darmon, M | 1 |
| Kelly, SJ | 1 |
| Moran, JL | 1 |
| Williams, PJ | 1 |
| Burns, K | 1 |
| Rowland, A | 1 |
| Miners, JO | 1 |
| Peake, SL | 1 |
| Nair, A | 1 |
| Chiumello, D | 1 |
| Gotti, M | 1 |
| Vergani, G | 1 |
| Hersch, M | 1 |
| Raveh, D | 1 |
| Izbicki, G | 1 |
| Greenberg, RS | 1 |
| Chen, H | 1 |
| Hasday, JD | 1 |
| Memis, D | 1 |
| Inal, MT | 1 |
| Temizoz, O | 1 |
| Genchallac, H | 1 |
| Ozdemir, H | 1 |
| Sut, N | 1 |
| Ogungbenro, K | 1 |
| Vasist, L | 1 |
| Maclaren, R | 2 |
| Dukes, G | 1 |
| Young, M | 1 |
| Aarons, L | 1 |
| Lines, SW | 1 |
| Wood, A | 1 |
| Bellamy, MC | 1 |
| Lewington, AJ | 1 |
| Selladurai, S | 1 |
| Saxena, MK | 1 |
| Hammond, NE | 1 |
| Taylor, C | 1 |
| Reade, MC | 1 |
| Jefferies, S | 1 |
| Niven, DJ | 2 |
| Léger, C | 2 |
| Kubes, P | 2 |
| Stelfox, HT | 2 |
| Laupland, KB | 2 |
| Krajčová, A | 1 |
| Matoušek, V | 1 |
| Duška, F | 1 |
| Vera, P | 1 |
| Zapata, L | 1 |
| Gich, I | 1 |
| Mancebo, J | 1 |
| Betbesé, AJ | 1 |
| Egi, M | 1 |
| Cruz, P | 1 |
| Garutti, I | 1 |
| Díaz, S | 1 |
| Fernández-Quero, L | 1 |
| McGuire, BM | 1 |
| Tamion, F | 1 |
| Hamelin, K | 1 |
| Duflo, A | 1 |
| Girault, C | 1 |
| Richard, JC | 1 |
| Bonmarchand, G | 1 |
| Schulman, CI | 1 |
| Namias, N | 1 |
| Doherty, J | 1 |
| Manning, RJ | 1 |
| Li, P | 2 |
| Elhaddad, A | 1 |
| Alhaddad, A | 1 |
| Lasko, D | 1 |
| Amortegui, J | 1 |
| Dy, CJ | 1 |
| Dlugasch, L | 1 |
| Baracco, G | 1 |
| Cohn, SM | 1 |
| Hodgman, MJ | 1 |
| Horn, JF | 1 |
| Stork, CM | 1 |
| Marraffa, JM | 1 |
| Holland, MG | 1 |
| Cantor, R | 1 |
| Carmel, PM | 1 |
| Karon, BS | 1 |
| Griesmann, L | 1 |
| Scott, R | 1 |
| Bryant, SC | 1 |
| Dubois, JA | 1 |
| Shirey, TL | 1 |
| Presti, S | 1 |
| Santrach, PJ | 1 |
| Dive, A | 1 |
| Miesse, C | 1 |
| Galanti, L | 1 |
| Jamart, J | 1 |
| Evrard, P | 1 |
| Gonzalez, M | 1 |
| Installé, E | 1 |
| Heyland, DK | 2 |
| Tougas, G | 2 |
| Cook, DJ | 2 |
| Guyatt, GH | 1 |
| King, D | 1 |
| Poblete, B | 1 |
| Romand, JA | 1 |
| Pichard, C | 1 |
| König, P | 1 |
| Suter, PM | 1 |
| Frost, P | 1 |
| Edwards, N | 1 |
| Bihari, D | 1 |
| Boyle, M | 1 |
| Hundy, S | 1 |
| Torda, TA | 1 |
| Kuhl, DA | 1 |
| Gervasio, JM | 1 |
| Brown, RO | 1 |
| Dickerson, RN | 1 |
| Livingston, TN | 1 |
| Swift, K | 1 |
| Headley, S | 1 |
| Kudsk, KA | 1 |
| Lima, JJ | 1 |
| Cohen, J | 1 |
| Aharon, A | 1 |
| Singer, P | 1 |
| Mackenzie, I | 1 |
| Forrest, K | 1 |
| Thompson, F | 1 |
| Marsh, R | 1 |
| Henker, R | 1 |
| Rogers, S | 1 |
| Kramer, DJ | 1 |
| Kelso, L | 1 |
| Kerr, M | 1 |
| Sereika, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Bromocriptine to Reduce Body Temperature in Febrile Critically-ill Adults With Acute Neurologic Disease: an Open-label, Blinded Endpoint, Randomized Controlled Trial[NCT03496545] | Phase 1/Phase 2 | 47 participants (Actual) | Interventional | 2018-11-30 | Completed | ||
| Haemodynamic Effects of Paracetamol (Acetaminophen) as Extended Intravenous Infusion Versus Intravenous Bolus in Septic Shock Patients[NCT06076980] | Phase 4 | 61 participants (Actual) | Interventional | 2020-11-01 | Completed | ||
| Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Patients: Randomized Double-blind Controlled Study[NCT05071352] | Phase 3 | 60 participants (Anticipated) | Interventional | 2021-10-01 | Recruiting | ||
| Control of Fever in Septic Patients[NCT04227652] | 140 participants (Actual) | Interventional | 2013-09-03 | Completed | |||
| Safety and Antipyretic Efficacy of Acetaminophen in the Febrile Intensive Care Unit Patient.[NCT02280239] | Phase 4 | 10 participants (Actual) | Interventional | 2015-05-31 | Terminated (stopped due to Only enrolled 10 participants over 9 months which is less then anticipated (75).) | ||
| Effects of Intravenous Acetaminophen on Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: a Randomized Controlled Trial[NCT01869699] | Phase 4 | 41 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Effect of Celiac Plexus Block on Gastric Emptying and Symptoms Caused by Gastroparesis[NCT02420925] | 0 participants (Actual) | Interventional | 2014-10-31 | Withdrawn (stopped due to "enrollment 0") | |||
| Comparison of the Efficacy of Paracetamol and Ibuprofen in the Management of Fever in Sepsis Patients: A Randomized Double-Blind Controlled Study[NCT06061575] | Phase 4 | 84 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| Assessment of the Safety of Anti-pyretic Therapy in Critically Ill Adults[NCT01173367] | Phase 2 | 26 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Mean total body temperature burden above 37°C over 48 hours during which patient receives either control or intervention medication. (NCT03496545)
Timeframe: over 48 hours
| Intervention | Temperature in degrees Celsius (Mean) |
|---|---|
| Acetaminophen | 37.8 |
| Bromocriptine and Acetaminophen | 37.7 |
Time in minutes where the temperature is ≥ 38.3ºC during the 48 hours of control versus intervention administration. (NCT03496545)
Timeframe: 48 hours
| Intervention | Minutes (Mean) |
|---|---|
| Acetaminophen | 216 |
| Bromocriptine and Acetaminophen | 300 |
Time in minutes it took after medication administration for the temperature to reach < 37.5ºC. (NCT03496545)
Timeframe: 48 hours
| Intervention | Minutes (Mean) |
|---|---|
| Acetaminophen | 253.5 |
| Bromocriptine and Acetaminophen | 556 |
Episodes of symptomatic hypotension, including decrease in supine systolic and diastolic pressures of greater than 20mm and 10mm Hg respectively with patient reported accompanying symptoms of light headedness or dizziness and incidence of nausea and headache. (NCT03496545)
Timeframe: Nursing assessment at every shift during 48 hour study period after first drug administration
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Decrease in blood pressure | Nausea | Headache | |
| Acetaminophen | 12 | 2 | 8 |
| Bromocriptine and Acetaminophen | 17 | 3 | 12 |
Clinically significant hypotension is defined as an acute drop in mean arterial pressure requiring treatment. Treatment is defined as either a 500 cc (or greater) fluid bolus and/or an increase in inotrope support of greater than 5 mcg/min over baseline. (NCT02280239)
Timeframe: 4 hours post acetaminophen administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Control Group | 0 |
| Acetaminophen Group | 0 |
systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressures (MAP) will be monitored for 4 hours post intervention (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mmHg (Mean) | |||||
|---|---|---|---|---|---|---|
| SBP: Pre-Intervention (2 hours) | SBP: Post-Intervention (4 hours) | DBP: Pre-Intervention (2 hours) | DBP: Post-Intervention (4 hours) | MAP: Pre-Intervention (2 hours) | MAP: Post-Intervention (4 hours) | |
| Acetaminophen Group | 122.6 | 119.5 | 66.2 | 65.4 | 84.1 | 82.4 |
| Control Group | 141.6 | 141.5 | 57.4 | 51.0 | 80.8 | 75.5 |
"Total dose of all vasoactive medications will be converted to total Equidose value (with the formula 10 mcg/min norepinephrine ≈ 5 mcg/kg/min dopamine ≈ 10 mcg/min epinephrine ≈ 1 mcg/min phenylephrine ≈ 0.02 u/min vasopressin as per Russell et al. (2008)) before comparing the treatment and control groups~Only 2 of the 6 participants were on low-dose vasoactive medications, (i.e., one was on norepinephrine and the other was on milrinone) therefore the pre-planned conversion calculation was not done." (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mcg (Number) | |||
|---|---|---|---|---|
| Pre-Intervention (2 hours) TOTAL Norepinephrine | Pre-Intervention (2 hours) TOTAL Milrinone | Post-Intervention (4 hours) TOTAL Norepinephrine | Post-Intervention (4 hours) TOTAL Milrinone | |
| Acetaminophen Group | NA | 6000.0 | NA | 7000.0 |
| Control Group | 167.0 | NA | 576.0 | NA |
Total crystalloid and colloid fluid will be converted the the equi-volume dose (with the ratio 1.4:1 (as per Finfer et al.(2004) & Vincent and Weil (2006) before making comparisons between the treatment and control groups. (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mL (Mean) | |||
|---|---|---|---|---|
| Pre-Intervention (2 hours) Total fluid INTAKE | Pre-Intervention (2 hours) Total fluid OUTPUT | Post-Intervention (4 hours) Total Fluid INTAKE | Post-Intervention (4 hours) Total Fluid OUTPUT | |
| Acetaminophen Group | 298 | 370 | 612 | 852 |
| Control Group | 235 | 80 | 734 | 245 |
"Continuous measurements of core body temperature will be recorded for 6 hours. Fever burden (FB) is defined as area between the 6 hour temperature curve and 38.3°C cut-off and it is reported in °C-hour.~PRE-INTERVENTION FB: is reported for a 2 hour period. POST-INTERVENTION FB: post-intervention fever burden is reported for a 6 hour period and average hourly fever burden.~Peak Temperature: is the highest recorded temperature for the study period in °C Minimum Temperature: is the lowest recorded temperature for the study period in °C" (NCT02280239)
Timeframe: 6 hours post intervention
| Intervention | °C*hours (Mean) | |
|---|---|---|
| Pre-Intervention FB (2 hours) | Post-Intervention FB (6 hours) | |
| Acetaminophen Group | 2.16 | 5.65 |
| Control Group | 0.97 | 0.74 |
change over time core temperature after study drug administration (adjusted to baseline core temperature) (NCT01869699)
Timeframe: 2 hours
| Intervention | degrees Celsius (Mean) |
|---|---|
| Normal Saline Placebo | -0.01 |
| Acetaminophen | -0.8 |
2-hour change over time heart rate from time of study drug administration (means adjusted to baseline HR) (NCT01869699)
Timeframe: Baseline to 2 hours
| Intervention | BPM (Mean) |
|---|---|
| Normal Saline Placebo | 2 |
| Acetaminophen | -6 |
2-hour change over time SBP from study drug administration (means adjusted to baseline SBP) (NCT01869699)
Timeframe: Baseline to 2 hours
| Intervention | mm Hg (Mean) |
|---|---|
| Normal Saline Placebo | -0.1 |
| Acetaminophen | -24 |
time-weighted average core body temperature over 4 hours. Core temperature was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the core temperature values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration
| Intervention | degrees Celsius (Mean) |
|---|---|
| Normal Saline Placebo | 38.4 |
| Acetaminophen | 37.9 |
time-weighted average heart rate over 4 hours. Heart rate was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the heart rate values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration
| Intervention | beats per minute (Mean) |
|---|---|
| Normal Saline Placebo | 92 |
| Acetaminophen | 87 |
time weighted average for respiratory rate over 4 hours. Respiratory rate was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the respiratory rate values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration
| Intervention | breaths per minute (Mean) |
|---|---|
| Normal Saline Placebo | 22 |
| Acetaminophen | 21 |
time-weighted average systolic blood pressure over 4 hours. Systolic blood pressure was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the systolic blood pressure values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration
| Intervention | mm Hg (Mean) |
|---|---|
| Normal Saline Placebo | 143 |
| Acetaminophen | 127 |
8 reviews available for acetaminophen and Critical Illness
| Article | Year |
|---|---|
A narrative review of paracetamol-induced hypotension: Keeping the patient safe.
Topics: Acetaminophen; Critical Illness; Fever; Humans; Hypotension; Hypotension, Controlled | 2022 |
[Antipyretics in intensive care patients].
Topics: Acetaminophen; Antipyretics; Critical Care; Critical Illness; Fever; Humans; Sepsis | 2017 |
Intravenous Acetaminophen-Induced Hypotension: A Review of the Current Literature.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Blood Pressure; Critical Illne | 2019 |
Measurement of gastric emptying in the critically ill.
Topics: 3-O-Methylglucose; Acetaminophen; Breath Tests; Critical Illness; Databases, Factual; Enteral Nutrit | 2015 |
Paracetamol in fever in critically ill patients-an update.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Critical Illness; Cyclooxygenase | 2017 |
Paracetamol in critical illness: a review.
Topics: Acetaminophen; Analgesics; Antipyretics; Critical Illness; Drug-Related Side Effects and Adverse Rea | 2012 |
[Fever in non-neurological critically ill patients; friends or foe?].
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Clinical Trials as T | 2011 |
The critically ill liver patient: fulminant hepatic failure.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Brain Edema; Critical Illness; Diagnosis, D | 2003 |
16 trials available for acetaminophen and Critical Illness
| Article | Year |
|---|---|
Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial.
Topics: Acetaminophen; Adult; Aged; Blood Pressure; Body Temperature; Critical Illness; Double-Blind Method; | 2017 |
Pharmacokinetic Study of Intravenous Acetaminophen Administered to Critically Ill Multiple-Trauma Patients at the Usual Dosage and a New Proposal for Administration.
Topics: Acetaminophen; Administration, Intravenous; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic | 2017 |
Population pharmacokinetics of intravenous paracetamol in critically ill patients with traumatic brain injury.
Topics: Acetaminophen; Adult; Antipyretics; Area Under Curve; Brain Injuries, Traumatic; Critical Illness; D | 2018 |
Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cell-Free System; Creatinine; Critical Illness; Doub | 2015 |
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
Topics: Acetaminophen; Aged; Body Temperature; Critical Illness; Double-Blind Method; Female; Fever; Humans; | 2015 |
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
Topics: Acetaminophen; Aged; Body Temperature; Critical Illness; Double-Blind Method; Female; Fever; Humans; | 2015 |
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
Topics: Acetaminophen; Aged; Body Temperature; Critical Illness; Double-Blind Method; Female; Fever; Humans; | 2015 |
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
Topics: Acetaminophen; Aged; Body Temperature; Critical Illness; Double-Blind Method; Female; Fever; Humans; | 2015 |
Haemodynamic effects of parenteral vs. enteral paracetamol in critically ill patients: a randomised controlled trial.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Critical Care; Critical Illness; Drug Administration | 2016 |
The effect of celiac plexus block in critically ill patients intolerant of enteral nutrition: a randomized, placebo-controlled study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anesthesia; APACHE; Blood Glucose; | 2010 |
Assessment of the safety and feasibility of administering antipyretic therapy in critically ill adults: a pilot randomized clinical trial.
Topics: Acetaminophen; Aged; Antipyretics; Chi-Square Distribution; Critical Illness; Feasibility Studies; F | 2013 |
[Metamizol versus propacetamol: comparative study of the hemodynamic and antipyretic effects in critically ill patients].
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Critical Illness; Dipyrone; Female; Fever; H | 2002 |
Gastric emptying in mechanically ventilated critically ill patients: effect of neuromuscular blocking agent.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Atracurium; Conscious Sedation; Critical Illne | 2003 |
The effect of antipyretic therapy upon outcomes in critically ill patients: a randomized, prospective study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Body Temperature; Body Temperature Regulation; | 2005 |
Effect of erythromycin on gastric motility in mechanically ventilated critically ill patients: a double-blind, randomized, placebo-controlled study.
Topics: Acetaminophen; Adult; Aged; Critical Illness; Cross-Over Studies; Double-Blind Method; Erythromycin; | 1995 |
Cisapride improves gastric emptying in mechanically ventilated, critically ill patients. A randomized, double-blind trial.
Topics: Acetaminophen; Anti-Ulcer Agents; Cisapride; Critical Illness; Double-Blind Method; Female; Gastric | 1996 |
Metabolic effects of i.v. propacetamol, metamizol or external cooling in critically ill febrile sedated patients.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Critical Illness; Cross-Over St | 1997 |
Sequential single doses of cisapride, erythromycin, and metoclopramide in critically ill patients intolerant to enteral nutrition: a randomized, placebo-controlled, crossover study.
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Antiemetics; Cisapride; Critical Illness; Cross-Ov | 2000 |
Comparison of fever treatments in the critically ill: a pilot study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Combined Modality Therapy; Critical Care; Critical Illness; | 2001 |
40 other studies available for acetaminophen and Critical Illness
| Article | Year |
|---|---|
Dosing of enteral acetaminophen in critically ill children: a cohort study.
Topics: Acetaminophen; Child; Cohort Studies; Critical Illness; Drug Overdose; Humans; Intensive Care Units, | 2022 |
The antipyretic effectiveness of dipyrone in the intensive care unit: A retrospective cohort study.
Topics: Acetaminophen; Antipyretics; Critical Illness; Dipyrone; Humans; Intensive Care Units; Retrospective | 2022 |
Liver enzymes after short-term acetaminophen error in critically ill children: a cohort study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Cohort Studies; Critical Illness; Humans; Liver; Ret | 2022 |
The association of prior paracetamol intake with outcome of very old intensive care patients with COVID-19: results from an international prospective multicentre trial.
Topics: Acetaminophen; COVID-19; Critical Care; Critical Illness; Humans; Pandemics; Prospective Studies | 2022 |
Bacterial and fungal infections: a frequent and deadly complication among critically ill acute liver failure patients.
Topics: Acetaminophen; Critical Illness; Humans; Intensive Care Units; Mycoses; Respiration, Artificial; Ret | 2023 |
Population Pharmacokinetic Modeling and Dose Optimization of Acetaminophen and its Metabolites Following Intravenous Infusion in Critically ill Adults.
Topics: Acetaminophen; Administration, Intravenous; Adult; Critical Illness; Glucuronides; Humans; Infusions | 2023 |
Antipyretic Efficacy of Acetaminophen and Ibuprofen in Critically Ill Pediatric Patients.
Topics: Acetaminophen; Antipyretics; Body Temperature; Child; Child, Preschool; Critical Illness; Female; Fe | 2019 |
Enteral Acetaminophen Bioavailability in Pediatric Intensive Care Patients Determined With an Oral Microtracer and Pharmacokinetic Modeling to Optimize Dosing.
Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Biological Availability; Child; Ch | 2019 |
Intravenous frusemide does not interact pharmacodynamically with acetaminophen in critically ill preterm neonates with patent ductus arteriosus.
Topics: Acetaminophen; Administration, Intravenous; Critical Illness; Ductus Arteriosus, Patent; Female; Fur | 2021 |
An examination of gastrointestinal absorption using the acetaminophen absorption test in critically ill patients with COVID-19: A retrospective cohort study.
Topics: Acetaminophen; COVID-19; Critical Illness; Humans; Intestinal Absorption; Retrospective Studies; SAR | 2021 |
Haemodynamic changes with paracetamol in critically-ill children.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Blood Pressure; Child; Child, Hospitaliz | 2017 |
Effect of Acetaminophen on the Prevention of Acute Kidney Injury in Patients With Sepsis.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Aged; Critical Illness; Female; Humans; Intensive Care Un | 2018 |
Continuous Intravenous Acetaminophen for Analgesia: First, Back to the Drawing Table?
Topics: Acetaminophen; Administration, Intravenous; Analgesia; Critical Illness; Humans; Pain Management | 2017 |
Paracetamol clinical dosing routine leads to paracetamol underexposure in an adult severely ill sub-Saharan African hospital population: a drug concentration measurement study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Biological Availability; Critical Illness; Cro | 2017 |
The Effect of Acetaminophen on Temperature in Critically Ill Children: A Retrospective Analysis of Over 50,000 Doses.
Topics: Acetaminophen; Antipyretics; Body Temperature; Child; Cohort Studies; Critical Illness; Fever; Human | 2018 |
Hypotensive Response to IV Acetaminophen in Pediatric Cardiac Patients.
Topics: Acetaminophen; Administration, Intravenous; Age Factors; Analgesics, Non-Narcotic; Blood Pressure; C | 2019 |
Beyond Opioids for Pain Management in Adult Critically Ill Patients.
Topics: Acetaminophen; Adrenergic alpha-2 Receptor Agonists; Adult; Analgesia; Analgesics; Analgesics, Non-N | 2019 |
Prescribing nonopioids in mechanically ventilated critically ill patients.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Chi-Square Distribution; C | 2013 |
Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; APACHE; Apoptosis; Chemical and Drug Induced L | 2013 |
Apoptosis or necrosis in acetaminophen-induced acute liver failure? New insights from mechanistic biomarkers*.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Apoptosis; Chemical and Drug Induced Liver Injury; Critical | 2013 |
Paracetamol therapy and outcome of critically ill patients: a multicenter retrospective observational study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Critical Illness; Hospital Mortality; Humans; Intensive Car | 2015 |
Intravenous Versus Oral Acetaminophen for Pain Control in Neurocritical Care Patients.
Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 | 2016 |
Acetaminophen-Induced Changes in Systemic Blood Pressure in Critically Ill Patients: Results of a Multicenter Cohort Study.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Critical Illness; Female; Humans; Hyp | 2016 |
Does mannitol contribute to hypotension after parenteral paracetamol administration in critical care?
Topics: Acetaminophen; Critical Care; Critical Illness; Hemodynamics; Humans; Hypotension; Mannitol | 2017 |
Effect of intravenous propacetamol on blood pressure in febrile critically ill patients.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Blood Pressure; | 2008 |
Effect of intravenous propacetamol on blood pressure in febrile critically ill patients.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Blood Pressure; | 2008 |
Effect of intravenous propacetamol on blood pressure in febrile critically ill patients.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Blood Pressure; | 2008 |
Effect of intravenous propacetamol on blood pressure in febrile critically ill patients.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Blood Pressure; | 2008 |
Acetaminophen has limited antipyretic activity in critically ill patients.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Critical Care; Critical Illness; Female; | 2010 |
A semi-mechanistic gastric emptying model for the population pharmacokinetic analysis of orally administered acetaminophen in critically ill patients.
Topics: Acetaminophen; Administration, Oral; Algorithms; Analgesics, Non-Narcotic; Antiemetics; Critical Ill | 2011 |
The outcomes of critically ill patients with combined severe acute liver and kidney injury secondary to paracetamol toxicity requiring renal replacement therapy.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Critical Illness; | 2011 |
Paracetamol therapy for septic critically ill patients: a retrospective observational study.
Topics: Acetaminophen; Antipyretics; Critical Illness; Female; Humans; Intensive Care Units; Male; Middle Ag | 2011 |
A survey of fever management for febrile intensive care patients without neurological injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Attitude of Health Personnel; Critical Illness; Fever; Heal | 2011 |
Assessment of the safety and feasibility of administering anti-pyretic therapy in critically ill adults: study protocol of a randomized trial.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alberta; Antipyretics; Body Temperature; Critical Illness; D | 2012 |
Mechanism of paracetamol-induced hypotension in critically ill patients: a prospective observational cross-over study.
Topics: Acetaminophen; Aged; Antipyretics; Body Temperature; Critical Illness; Cross-Over Studies; Female; H | 2013 |
[Hemodynamic and antipyretic effects of paracetamol, metamizol and dexketoprofen in critical patients].
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics | 2012 |
Profound metabolic acidosis and oxoprolinuria in an adult.
Topics: Acetaminophen; Acidosis; Analgesics, Non-Narcotic; Critical Illness; Female; Humans; Metabolic Disea | 2007 |
Evaluation of the impact of hematocrit and other interference on the accuracy of hospital-based glucose meters.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Blood Chemical Analysis; Bloo | 2008 |
Impaired gastric emptying in mechanically ventilated, critically ill patients.
Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Analysis of Variance; Case-Control Studies; Critical | 1996 |
Gastric emptying in the critically ill--the way forward?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Critical Care; Critical Illness; Enteral Nutrition; Gastric | 1997 |
Paracetamol administration is associated with hypotension in the critically ill.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Critical Care; Critical Illness; Drug Monitoring; Fem | 1997 |
Paracetamol administration is associated with hypotension in the critically ill.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Critical Care; Critical Illness; Drug Monitoring; Fem | 1997 |
Paracetamol administration is associated with hypotension in the critically ill.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Critical Care; Critical Illness; Drug Monitoring; Fem | 1997 |
Paracetamol administration is associated with hypotension in the critically ill.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Critical Care; Critical Illness; Drug Monitoring; Fem | 1997 |
The paracetamol absorption test: a useful addition to the enteral nutrition algorithm?
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Algorithms; Critical Illness; Enteral Nutrition; Fema | 2000 |
Effects of acetaminophen administration to patients in intensive care.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Critical Illness; Female; Heart Rate; Hum | 2000 |
Effects of acetaminophen administration to patients in intensive care.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Critical Illness; Female; Heart Rate; Hum | 2000 |
Effects of acetaminophen administration to patients in intensive care.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Critical Illness; Female; Heart Rate; Hum | 2000 |
Effects of acetaminophen administration to patients in intensive care.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Critical Illness; Female; Heart Rate; Hum | 2000 |