Page last updated: 2024-10-22

acetaminophen and Cough

acetaminophen has been researched along with Cough in 19 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.

Research Excerpts

ExcerptRelevanceReference
"Use of acetaminophen in middle to late but not early pregnancy was significantly related to wheezing (odd ratio, 1."3.74Prenatal exposure to acetaminophen and respiratory symptoms in the first year of life. ( Busso, A; Chavez, N; Enriquez, R; Gutierrez, S; Hernandez, E; Pelzel, D; Persky, V; Piorkowski, J; Vergara, C; Wagner-Cassanova, C, 2008)
"Dysphagia and surgical incision pain scores were also significantly lower in the LMA group, compared with the ETT group, at 6 h and 12 h after surgery."2.90Comparison Between the Protector™ Laryngeal Mask Airway and the Endotracheal Tube for Minimally Invasive Thyroid and Parathyroid Surgery. ( Gkinas, D; Kotsovolis, G; Panidis, S; Papavramidis, T; Pliakos, I, 2019)
"The developed methods are successfully applied for concurrent quantification of the studied components in the marketed dosage form without interference from matrix excipients."2.82Novel Spectrophotometric Approaches for the Simultaneous Quantification of Ternary Common Cold Mixture Containing Paracetamol with a Challenging Formulation Ratio: Greenness Profile Evaluation. ( Fayez, YM; Monir, HH; Mostafa, NM; Rostom, Y; Soliman, RM, 2022)
"Morphine consumption was statistically lower in the TPVB group than in the PCA group at 24 h (P = 0."2.77Comparison between systemic analgesia, continuous wound catheter analgesia and continuous thoracic paravertebral block: a randomised, controlled trial of postthoracotomy pain management. ( Bernard, A; Fortier, S; Girard, C; Hanna, HA, 2012)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19903 (15.79)18.7374
1990's1 (5.26)18.2507
2000's3 (15.79)29.6817
2010's8 (42.11)24.3611
2020's4 (21.05)2.80

Authors

AuthorsStudies
Soliman, RM1
Mostafa, NM1
Fayez, YM1
Monir, HH1
Rostom, Y1
Oluyase, AO3
Bajwah, S3
Sleeman, KE3
Walshe, C3
Preston, N3
Hocaoglu, M3
Bradshaw, A3
Chambers, RL3
Murtagh, FEM3
Dunleavy, L3
Maddocks, M3
Fraser, LK3
Higginson, IJ3
Kotsovolis, G1
Pliakos, I1
Panidis, S1
Gkinas, D1
Papavramidis, T1
Paudel, S1
Aryal, B1
Elgamasy, S1
Kamel, MG1
Ghozy, S1
Khalil, A1
Morra, ME1
Islam, SMS1
Ocan, M1
Aono, M1
Bukirwa, C1
Luyinda, E1
Ochwo, C1
Nsambu, E1
Namugonza, S1
Makoba, J1
Kandaruku, E1
Muyende, H1
Nakawunde, A1
Jin, J1
Fassoulaki, A1
Chassiakos, D1
Melemeni, A1
Danno, K1
Cognet-Dementhon, B1
Thevenard, G1
Duru, G1
Allaert, FA1
Bordet, MF1
Persky, V1
Piorkowski, J1
Hernandez, E1
Chavez, N1
Wagner-Cassanova, C1
Vergara, C1
Pelzel, D1
Enriquez, R1
Gutierrez, S1
Busso, A1
Parish, J1
Fortier, S1
Hanna, HA1
Bernard, A1
Girard, C1
SALEM, H1
AVIADO, DM1
Dhingra, B1
Grover, C1
Jaffé, G1
Grimshaw, JJ1
Møiniche, S1
Bülow, S1
Hesselfeldt, P1
Hestbaek, A1
Kehlet, H1
Chafee, FH1
Settipane, GA1
Wang, J1
Han, N1
Wang, Y3
Liu, Z1
Yin, J1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study of the Laryngopharyngeal Symptoms After Minimally Invasive Thyroidectomy: Comparison Between the Protector Laryngeal Mask Airway and the Endotracheal Tube.[NCT03098667]79 participants (Actual)Interventional2017-02-01Completed
Randomized Prospective Study Comparing Paravertebral Catheters, Single Shot Paravertebral Block, Thoracic Epidural, for Postoperative Analgesia Following Video-assisted Thoracoscopic Surgery[NCT03151434]Phase 3147 participants (Actual)Interventional2017-02-07Completed
Continuous Paravertebral Block by Intraoperative Direct Access Versus Systemic Analgesia for Postthoracotomy Pain Relief[NCT04482192]Phase 363 participants (Actual)Interventional2015-06-15Completed
Effect of Oral Procaterol on Chronic Persistent Cough Following Upper Respiratory Tract Infection: Double-Blind Randomized Placebo-Controlled Trial[NCT02349919]74 participants (Anticipated)Interventional2015-03-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Average Nausea Scores Over 72 Hours

Nausea scores will be collected by a study team member post operatively up to 3 days per protocol. Nausea will be recorded as 0=none, 1=mild, 2=moderate, or 3=severe (NCT03151434)
Timeframe: Nausea scores will be documented at 1 hour post op, 24,48,and 72 hours after the surgery.The scores will then be averaged.

Interventionunits on a scale (Mean)
Group #10.27
Group #20.27
Group #30.29

Average Sedation Scores Over 72 Hours

Sedation scores will be documented by a study team member post operatively up to 3 days per protocol requirements. Determining if patient is 0=awake and alert, 1=quietly awake, 2=asleep and arousable, or 3=deep sleep. (NCT03151434)
Timeframe: Sedation scores will be documented at 1 hour post op, 24,48,and 72 hours after the sugery. The scores will then be averaged.

Interventionunits on a scale (Mean)
Group #10.38
Group #20.32
Group #30.22

Secondary Endpoint Includes Total Intravenous Opioid Consumption at 72 Hours

Opioid consumption will be collected by a study team member post operatively up to 3 days per protocol time requirements (NCT03151434)
Timeframe: Opioid consumption will be measured at 1 hour post op, 24,48, and 72 hours post op. The total amount will be recorded.

Interventionmiligram morphine equivalent (Median)
Group #157
Group #235
Group #321.3

Subjects Overall Satisfaction Scores

Subjects will be followed up at 24 hours post operatively by a study team member to document patient overall satisfaction scores. Score was recorded as 0=dissatisfied, 1=satisfied, 2=very satisfied. (NCT03151434)
Timeframe: post operatively at hour 24

Interventionunits on a scale (Mean)
Group #10.89
Group #20.95
Group #31.33

Subjects Overall Satisfaction Scores

Subjects will be followed up at 48 hours post operatively by a study team member to document patient overall satisfaction scores. Scores will be recorded as 0=dissatisfied, 1=satisfied, 2=very satisfied. (NCT03151434)
Timeframe: post operatively at hour 48

Interventionunits on a scale (Mean)
Group #11.19
Group #21.05
Group #31.32

The Primary Endpoint of This Study Will be VAS Pain Score at 24 Hours

"The VAS score will be taken with both rest and movement (knee flexion) and will be measured by a study team investigator using Visual Analog Scale (VAS). Using units on a scale of 1-10 for documentation with 10 being the worst pain and 0 being no pain" (NCT03151434)
Timeframe: Pain scores will be measured 24 hours after surgery.

Interventionunits on a scale (Median)
US Guided Single Shot Paravertebral Block4.0
US Guided Paravertebral Catheter4.5
Thoracic Epidural3.0

The Primary Endpoint of This Study Will be VAS Pain Score at 48 Hours

"The VAS scores will be taken with both rest and movement (knee flexion) and will be measured by a study team investigator using Visual Analog Scale (VAS). Usingunits on a scale scale of 1-10 for documentation with 10 being the worst pain and 0 being no pain" (NCT03151434)
Timeframe: Pain scores will be measured 48 hours after surgery.

Interventionunits on a scale (Median)
US Guided Single Shot Paravertebral Block3.0
US Guided Paravertebral Catheter4.0
Thoracic Epidural2.0

Reviews

2 reviews available for acetaminophen and Cough

ArticleYear
Novel Spectrophotometric Approaches for the Simultaneous Quantification of Ternary Common Cold Mixture Containing Paracetamol with a Challenging Formulation Ratio: Greenness Profile Evaluation.
    Journal of AOAC International, 2022, Sep-06, Volume: 105, Issue:5

    Topics: Acetaminophen; Common Cold; Cough; COVID-19; Humans; Pseudoephedrine; Spectrophotometry

2022
ANTITUSSIVE DRUGS, WITH SPECIAL REFERENCE TO A NEW THEORY FOR THE INITATION OF THE COUGH REFLEX AND THE INFLUENCE OR BRONCHODILATORS.
    The American journal of the medical sciences, 1964, Volume: 247

    Topics: Acetaminophen; Aerosols; Aminophylline; Analgesics; Analgesics, Non-Narcotic; Animals; Antimony; Ant

1964

Trials

4 trials available for acetaminophen and Cough

ArticleYear
Comparison Between the Protector™ Laryngeal Mask Airway and the Endotracheal Tube for Minimally Invasive Thyroid and Parathyroid Surgery.
    World journal of surgery, 2019, Volume: 43, Issue:11

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Cough; Deglutition Disorders; Female; Humans;

2019
Intermittent epidural vs continuous wound infusion of ropivacaine for acute and chronic pain control after hysterectomy or myomectomy: a randomized controlled trial.
    Pain medicine (Malden, Mass.), 2014, Volume: 15, Issue:9

    Topics: Acetaminophen; Acute Pain; Adult; Amides; Analgesia, Epidural; Analgesics; Anesthetics, Local; Chron

2014
Comparison between systemic analgesia, continuous wound catheter analgesia and continuous thoracic paravertebral block: a randomised, controlled trial of postthoracotomy pain management.
    European journal of anaesthesiology, 2012, Volume: 29, Issue:11

    Topics: Acetaminophen; Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; An

2012
Comparison between systemic analgesia, continuous wound catheter analgesia and continuous thoracic paravertebral block: a randomised, controlled trial of postthoracotomy pain management.
    European journal of anaesthesiology, 2012, Volume: 29, Issue:11

    Topics: Acetaminophen; Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; An

2012
Comparison between systemic analgesia, continuous wound catheter analgesia and continuous thoracic paravertebral block: a randomised, controlled trial of postthoracotomy pain management.
    European journal of anaesthesiology, 2012, Volume: 29, Issue:11

    Topics: Acetaminophen; Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; An

2012
Comparison between systemic analgesia, continuous wound catheter analgesia and continuous thoracic paravertebral block: a randomised, controlled trial of postthoracotomy pain management.
    European journal of anaesthesiology, 2012, Volume: 29, Issue:11

    Topics: Acetaminophen; Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; An

2012
Randomized single-blind trial in general practice comparing the efficacy and palatability of two cough linctus preparations, 'Pholcolix' and 'Actifed' Compound, in children with acute cough.
    Current medical research and opinion, 1983, Volume: 8, Issue:8

    Topics: Acetaminophen; Antitussive Agents; Child; Codeine; Cough; Drug Combinations; Ephedrine; Female; Huma

1983

Other Studies

13 other studies available for acetaminophen and Cough

ArticleYear
Symptom management in people dying with COVID-19: multinational observational study.
    BMJ supportive & palliative care, 2022, Volume: 12, Issue:4

    Topics: Acetaminophen; Benzodiazepines; Cough; COVID-19; Humans; Palliative Care

2022
Symptom management in people dying with COVID-19: multinational observational study.
    BMJ supportive & palliative care, 2022, Volume: 12, Issue:4

    Topics: Acetaminophen; Benzodiazepines; Cough; COVID-19; Humans; Palliative Care

2022
Symptom management in people dying with COVID-19: multinational observational study.
    BMJ supportive & palliative care, 2022, Volume: 12, Issue:4

    Topics: Acetaminophen; Benzodiazepines; Cough; COVID-19; Humans; Palliative Care

2022
Symptom management in people dying with COVID-19: multinational observational study.
    BMJ supportive & palliative care, 2022, Volume: 12, Issue:4

    Topics: Acetaminophen; Benzodiazepines; Cough; COVID-19; Humans; Palliative Care

2022
Symptom management in people dying with COVID-19: multinational observational study.
    BMJ supportive & palliative care, 2022, Volume: 12, Issue:4

    Topics: Acetaminophen; Benzodiazepines; Cough; COVID-19; Humans; Palliative Care

2022
Symptom management in people dying with COVID-19: multinational observational study.
    BMJ supportive & palliative care, 2022, Volume: 12, Issue:4

    Topics: Acetaminophen; Benzodiazepines; Cough; COVID-19; Humans; Palliative Care

2022
Symptom management in people dying with COVID-19: multinational observational study.
    BMJ supportive & palliative care, 2022, Volume: 12, Issue:4

    Topics: Acetaminophen; Benzodiazepines; Cough; COVID-19; Humans; Palliative Care

2022
Symptom management in people dying with COVID-19: multinational observational study.
    BMJ supportive & palliative care, 2022, Volume: 12, Issue:4

    Topics: Acetaminophen; Benzodiazepines; Cough; COVID-19; Humans; Palliative Care

2022
Symptom management in people dying with COVID-19: multinational observational study.
    BMJ supportive & palliative care, 2022, Volume: 12, Issue:4

    Topics: Acetaminophen; Benzodiazepines; Cough; COVID-19; Humans; Palliative Care

2022
Exploration of self-medication practice in Pokhara valley of Nepal.
    BMC public health, 2020, May-19, Volume: 20, Issue:1

    Topics: Acetaminophen; Adult; Analgesics; Anti-Bacterial Agents; Common Cold; Cough; Cross-Sectional Studies

2020
First case of focal epilepsy associated with SARS-coronavirus-2.
    Journal of medical virology, 2020, Volume: 92, Issue:10

    Topics: Acetaminophen; Acetylcysteine; Aged; Ambroxol; Anticonvulsants; Cough; COVID-19; COVID-19 Drug Treat

2020
Medicine use practices in management of symptoms of acute upper respiratory tract infections in children (≤12 years) in Kampala city, Uganda.
    BMC public health, 2017, 09-21, Volume: 17, Issue:1

    Topics: Acetaminophen; Acute Disease; Adult; Amoxicillin; Anti-Infective Agents; Artemether, Lumefantrine Dr

2017
Risks of Codeine and Tramadol in Children.
    JAMA, 2017, 10-17, Volume: 318, Issue:15

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Child, Preschool; Co

2017
Management of the early symptoms of influenza-like illnesses and ear, nose and throat (ENT) disorders by pharmacists.
    Homeopathy : the journal of the Faculty of Homeopathy, 2014, Volume: 103, Issue:4

    Topics: Acetaminophen; Adult; Common Cold; Cough; Disease Management; Early Diagnosis; Female; France; Homeo

2014
Prenatal exposure to acetaminophen and respiratory symptoms in the first year of life.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2008, Volume: 101, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Asthma; Breast Feeding; Cough; Female; H

2008
Best drugs for what ails you: the brands to buy--and those to skip.
    Consumer reports, 2009, Volume: 74, Issue:9

    Topics: Acetaminophen; Anesthetics, Local; Cetirizine; Chlorpheniramine; Common Cold; Cough; Dextromethorpha

2009
Social suffering and anxiety: deciphering coughs and colds at Akan anti-witchcraft shrines in Paris.
    Anthropology & medicine, 2011, Volume: 18, Issue:3

    Topics: Acetaminophen; Adult; Anthropology, Medical; Anxiety; Attitude; Cough; Female; Ghana; Humans; Interp

2011
Baboon syndrome.
    Indian pediatrics, 2007, Volume: 44, Issue:12

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Cefadroxil; Child, Preschool; Cough;

2007
Convalescence and hospital stay after colonic surgery with balanced analgesia, early oral feeding, and enforced mobilisation.
    The European journal of surgery = Acta chirurgica, 1995, Volume: 161, Issue:4

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Bupivacaine; Colectomy; Convales

1995
Asthma caused by FD&C approved dyes.
    The Journal of allergy, 1967, Volume: 40, Issue:2

    Topics: Acetaminophen; Adult; Angioedema; Aspirin; Asthma; Benzoates; Coloring Agents; Cough; Diethylstilbes

1967
Three alkaloids from Reineckia carnea herba and their antitussive and expectorant activities.
    Natural product research, 2014, Volume: 28, Issue:16

    Topics: Alkaloids; Aminophenols; Antitussive Agents; Cough; Drugs, Chinese Herbal; Expectorants; Liliaceae;

2014