acetaminophen has been researched along with Constitutional Liver Dysfunction in 8 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen bioactivation was quantified by the molar percentage of acetaminophen excreted in the urine during 24 hours as glutathione-derived conjugates (cysteine and mercapturic acid)." | 1.28 | Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndrome. ( de Morais, SM; Uetrecht, JP; Wells, PG, 1992) |
| "A group of eleven subjects with Gilbert's syndrome was characterized by conventional tests and determination of bilirubin and its conjugates in plasma by alkaline methanolysis and thin layer chromatography." | 1.27 | Normal pathways for glucuronidation, sulphation and oxidation of paracetamol in Gilbert's syndrome. ( Bircher, J; Blume, R; Bock, KW; Schröter, W; Sieg, A; Ullrich, D, 1987) |
| " No difference in the bioavailability of 500 mg paracetamol given orally was observed between the two groups." | 1.26 | Paracetamol (acetaminophen) kinetics in patients with Gilber's syndrome. ( Douglas, AP; Rawlins, MD; Savage, RL, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Raza, A | 1 |
| Vierling, J | 1 |
| Hussain, KB | 1 |
| Nakagawa, T | 1 |
| Mure, T | 1 |
| Yusoff, S | 1 |
| Ono, E | 1 |
| Harahap, IS | 1 |
| Morikawa, S | 1 |
| Morioka, I | 1 |
| Takeshima, Y | 1 |
| Nishio, H | 1 |
| Matsuo, M | 1 |
| Rauchschwalbe, SK | 1 |
| Zühlsdorf, MT | 1 |
| Wensing, G | 1 |
| Kuhlmann, J | 1 |
| Esteban, A | 1 |
| Pérez-Mateo, M | 1 |
| Douglas, AP | 1 |
| Savage, RL | 1 |
| Rawlins, MD | 1 |
| Patel, M | 1 |
| Tang, BK | 1 |
| Kalow, W | 1 |
| de Morais, SM | 1 |
| Uetrecht, JP | 1 |
| Wells, PG | 1 |
| Ullrich, D | 1 |
| Sieg, A | 1 |
| Blume, R | 1 |
| Bock, KW | 1 |
| Schröter, W | 1 |
| Bircher, J | 1 |
8 other studies available for acetaminophen and Constitutional Liver Dysfunction
| Article | Year |
|---|---|
Genetics of drug-induced hepatotoxicity toxicity in Gilbert's syndrome.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Chemical and Drug Induced | 2013 |
Acetaminophen administration in a patient with Gilbert's syndrome.
Topics: Acetaminophen; Administration, Oral; Antipyretics; Child; DNA; DNA Mutational Analysis; Dose-Respons | 2012 |
Glucuronidation of acetaminophen is independent of UGT1A1 promotor genotype.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Bilirubin; Genotype; Gilbert D | 2004 |
Gilbert's disease: a risk factor for paracetamol overdosage?
Topics: Acetaminophen; Biotransformation; Drug Overdose; Gilbert Disease; Humans; Risk Factors | 1993 |
Paracetamol (acetaminophen) kinetics in patients with Gilber's syndrome.
Topics: Acetaminophen; Adolescent; Adult; Female; Gilbert Disease; Half-Life; Humans; Hyperbilirubinemia, He | 1978 |
Variability of acetaminophen metabolism in Caucasians and Orientals.
Topics: Acetaminophen; Asian People; Female; Genetic Variation; Gilbert Disease; Humans; Male; Sulfates; Whi | 1992 |
Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndrome.
Topics: Acetaminophen; Adult; Biotransformation; Gilbert Disease; Glucuronates; Glucuronosyltransferase; Hum | 1992 |
Normal pathways for glucuronidation, sulphation and oxidation of paracetamol in Gilbert's syndrome.
Topics: Acetaminophen; Adolescent; Adult; Bilirubin; Female; Gilbert Disease; Glucuronates; Humans; Hyperbil | 1987 |