acetaminophen has been researched along with Coma in 25 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a case of early coma, metabolic acidosis and methemoglobinemia after substantial acetaminophen toxicity in the absence of hepatic failure." | 7.79 | Coma, metabolic acidosis, and methemoglobinemia in a patient with acetaminophen toxicity. ( Boucher, P; Dias, VC; Kanji, HD; Mithani, S; Yarema, MC, 2013) |
| " Although her consciousness and hemodynamic status gradually improved after treatment with N-acetylcysteine and other supportive measures, she was found to have pancytopenia, pancreatitis and hepatorenal failure during the hospitalization and eventually died 18 d post-admission." | 7.71 | Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning. ( Deng, JF; Lin, TJ; Yang, CC, 2001) |
| "Metabolic acidosis and coma may develop in patients who experience severe hepatic injury after acetaminophen poisoning." | 7.70 | Early metabolic acidosis and coma after acetaminophen ingestion. ( Blanc, P; Roth, B; Woo, O, 1999) |
| "To report a case of metabolic acidosis and coma in a severe acetaminophen overdose." | 7.70 | Metabolic acidosis and coma following a severe acetaminophen overdose. ( Jones, G; Koulouris, Z; Tierney, MG, 1999) |
| " Hemodialysis appears to be a beneficial therapeutic option in cases of massive acetaminophen ingestion with coma and lactic acidosis." | 3.83 | Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics. ( Ghannoum, M; Gosselin, S; Grunbaum, AM; Kazim, S; Villeneuve, E, 2016) |
| "Haemodialysis is sometimes used for patients with massive acetaminophen overdose when signs of "mitochondrial paralysis" (lactic acidosis, altered mental status, hypothermia and hyperglycaemia) are present." | 3.79 | Antidote removal during haemodialysis for massive acetaminophen overdose. ( Garland, JS; Hanly, LN; Juurlink, DN; Lenga, I; Poley, R; Sivilotti, ML; Thompson, M, 2013) |
| " Although her consciousness and hemodynamic status gradually improved after treatment with N-acetylcysteine and other supportive measures, she was found to have pancytopenia, pancreatitis and hepatorenal failure during the hospitalization and eventually died 18 d post-admission." | 3.71 | Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning. ( Deng, JF; Lin, TJ; Yang, CC, 2001) |
| "Metabolic acidosis and coma may develop in patients who experience severe hepatic injury after acetaminophen poisoning." | 3.70 | Early metabolic acidosis and coma after acetaminophen ingestion. ( Blanc, P; Roth, B; Woo, O, 1999) |
| "To report a case of metabolic acidosis and coma in a severe acetaminophen overdose." | 3.70 | Metabolic acidosis and coma following a severe acetaminophen overdose. ( Jones, G; Koulouris, Z; Tierney, MG, 1999) |
| "A 38-yr-old woman who by history ingested 13 g methylphenobarbital, alcohol, and 6 g acetaminophen became comatose slowly over 4 d." | 3.66 | Impaired metabolism of methylphenobarbital after a combined drug overdose: treatment by resin hemoperfusion. ( Humphreys, M; Jacob, P; Pond, S; Tong, T; Weiss, R, 1982) |
| "A case of metabolic acidosis, acute renal failure and hepatic failure following paracetamol ingestion is presented." | 1.27 | Paracetamol-associated coma, metabolic acidosis, renal and hepatic failure. ( Fassett, R; Kritharides, L; Singh, B, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (24.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 4 (16.00) | 29.6817 |
| 2010's | 9 (36.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Isbister, GK | 1 |
| Polanski, R | 1 |
| Cooper, JM | 1 |
| Keegan, M | 1 |
| Isoardi, KZ | 1 |
| Plewes, K | 1 |
| Turner, GDH | 1 |
| Dondorp, AM | 1 |
| Rangnekar, AS | 1 |
| Ellerbe, C | 1 |
| Durkalski, V | 1 |
| McGuire, B | 1 |
| Lee, WM | 1 |
| Fontana, RJ | 1 |
| Kanji, HD | 1 |
| Mithani, S | 1 |
| Boucher, P | 1 |
| Dias, VC | 1 |
| Yarema, MC | 1 |
| Sivilotti, ML | 1 |
| Juurlink, DN | 1 |
| Garland, JS | 1 |
| Lenga, I | 1 |
| Poley, R | 1 |
| Hanly, LN | 1 |
| Thompson, M | 1 |
| Villano, JH | 1 |
| O'Connell, CW | 1 |
| Ly, BT | 1 |
| Schneir, A | 1 |
| Ghannoum, M | 1 |
| Kazim, S | 1 |
| Grunbaum, AM | 1 |
| Villeneuve, E | 1 |
| Gosselin, S | 1 |
| Fridman, V | 1 |
| Galetta, SL | 1 |
| Pruitt, AA | 1 |
| Levine, JM | 1 |
| Wiegand, TJ | 1 |
| Margaretten, M | 1 |
| Olson, KR | 1 |
| Bodmer, M | 1 |
| Monte, AA | 1 |
| Nisse, P | 1 |
| Saulnier, F | 1 |
| Garat, A | 1 |
| Mathieu-Nolf, M | 1 |
| Steelman, R | 1 |
| Goodman, A | 1 |
| Biswas, S | 1 |
| Zimmerman, A | 1 |
| Mendoza, CD | 1 |
| Heard, K | 1 |
| Dart, RC | 1 |
| Pond, S | 1 |
| Jacob, P | 1 |
| Humphreys, M | 1 |
| Weiss, R | 1 |
| Tong, T | 1 |
| Mellergård, P | 1 |
| Hantson, P | 1 |
| Vekemans, MC | 1 |
| Laterre, PF | 1 |
| Vanormelingen, P | 1 |
| Mahieu, P | 1 |
| Koerner, MM | 1 |
| Roth, B | 1 |
| Woo, O | 1 |
| Blanc, P | 1 |
| Koulouris, Z | 1 |
| Tierney, MG | 1 |
| Jones, G | 1 |
| Al-Jubouri, MA | 1 |
| Yang, CC | 1 |
| Deng, JF | 1 |
| Lin, TJ | 1 |
| Kritharides, L | 1 |
| Fassett, R | 1 |
| Singh, B | 1 |
| Flanagan, RJ | 1 |
| Mant, TG | 1 |
| Wright, RC | 1 |
| Forrest, AH | 1 |
| Roscoe, P | 1 |
| Stevenson, IH | 1 |
| Prescott, LF | 1 |
| Done, AK | 1 |
| Temple, AR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial (RCT)[NCT05746819] | 256 participants (Anticipated) | Observational | 2021-01-02 | Enrolling by invitation | |||
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for acetaminophen and Coma
| Article | Year |
|---|---|
Pathophysiology, clinical presentation, and treatment of coma and acute kidney injury complicating falciparum malaria.
Topics: Acetaminophen; Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Brain; Coma; De | 2018 |
Treatment of salicylate poisoning.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Acute Kidney Injury; Alkalosis, Respiratory; Aspirin | 1971 |
23 other studies available for acetaminophen and Coma
| Article | Year |
|---|---|
Duloxetine overdose causes sympathomimetic and serotonin toxicity without major complications.
Topics: Acetaminophen; Adult; Antidepressive Agents; Arrhythmias, Cardiac; Coma; Diazepam; Droperidol; Drug | 2022 |
Quality of life is significantly impaired in long-term survivors of acute liver failure and particularly in acetaminophen-overdose patients.
Topics: Acetaminophen; Adult; Coma; Drug Overdose; Female; Follow-Up Studies; Humans; Liver Failure, Acute; | 2013 |
Coma, metabolic acidosis, and methemoglobinemia in a patient with acetaminophen toxicity.
Topics: Acetaminophen; Acidosis; Aged; Analgesics, Non-Narcotic; Coma; Female; Humans; Methemoglobinemia | 2013 |
Antidote removal during haemodialysis for massive acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; C | 2013 |
Case Files from the University of California San Diego Health System Fellowship Coma and Severe Acidosis: Remember to Consider Acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adult; Antidotes; Biomarkers; Coma; Drug Overdose; | 2015 |
Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adolescent; Coma; Drug Overdose; Emergency Service, | 2016 |
MRI findings associated with acute liver failure.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain; Brain Edema; Coma; Diphenhydramine; Hepatic E | 2009 |
Massive acetaminophen ingestion with early metabolic acidosis and coma: treatment with IV NAC and continuous venovenous hemodiafiltration.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Analgesics, Non-Narcotic; Antidotes; Coma; Combined Modalit | 2010 |
"Massive acetaminophen ingestion with early metabolic acidosis and coma: treatment with iv nac and continuous venovenous hemodiafiltration" by Wiegand et al., Clin Toxicol (Phila) 48:156-159.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Analgesics, Non-Narcotic; Coma; Drug Overdose; Half-Life; H | 2010 |
[Early coma and metabolic acidosis after massive paracetamol self poisoning].
Topics: Acetaminophen; Acidosis; Coma; Female; Humans; Middle Aged | 2012 |
Metabolic acidosis and coma in a child with acetaminophen toxicity.
Topics: Acetaminophen; Acidosis; Coma; Female; Humans; Infant | 2004 |
Coma, metabolic acidosis and normal liver function in a child with a large serum acetaminophen level.
Topics: Acetaminophen; Acidosis; Child, Preschool; Coma; Drug-Related Side Effects and Adverse Reactions; Fe | 2006 |
Impaired metabolism of methylphenobarbital after a combined drug overdose: treatment by resin hemoperfusion.
Topics: Acetaminophen; Adult; Alcoholic Intoxication; Alcoholism; Coma; Drug Interactions; Female; Hemoperfu | 1982 |
Monitoring of rectal, epidural, and intraventricular temperature in neurosurgical patients.
Topics: Acetaminophen; Body Temperature Regulation; Brain Damage, Chronic; Brain Diseases; Brain Injuries; C | 1994 |
Heart donation after fatal acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Coma; Female; Heart Transplantation; | 1997 |
Early metabolic acidosis and coma after acetaminophen ingestion.
Topics: Acetaminophen; Acidosis; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Live | 1999 |
Metabolic acidosis and coma following a severe acetaminophen overdose.
Topics: Acetaminophen; Acidosis; Adult; Coma; Drug Overdose; Female; Humans | 1999 |
Metabolic acidosis and coma after acetaminophen ingestion.
Topics: Acetaminophen; Acidosis; Analgesics, Non-Narcotic; Coma; Humans | 1999 |
Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Coma; Diagnosis, Diff | 2001 |
Paracetamol-associated coma, metabolic acidosis, renal and hepatic failure.
Topics: Acetaminophen; Acidosis; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Coma; F | 1988 |
Coma and metabolic acidosis early in severe acute paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Adolescent; Aged; Blood Gas Analysis; Chemical and Drug Ind | 1986 |
A simple plan for the management of drug overdosage.
Topics: Absorption; Acetaminophen; Antidepressive Agents; Barbiturates; Body Fluids; Charcoal; Coma; Female; | 1974 |
Abnormal drug metabolism following barbiturate and paracetamol overdosage.
Topics: Acetaminophen; Adult; Antipyrine; Barbiturates; Coma; Enzyme Induction; Half-Life; Humans; Liver; Mi | 1974 |