acetaminophen has been researched along with Cleft Palate in 13 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Cleft Palate: Congenital fissure of the soft and/or hard palate, due to faulty fusion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess opioid-sparing effects of oral or intravenous acetaminophen following primary cleft palate repair in children." | 9.19 | Analgesic effectiveness of acetaminophen for primary cleft palate repair in young children: a randomized placebo controlled trial. ( Applegate, RL; Hassanian, M; Martin, M; Mason, L; Nour, C; Ratsiu, J; Ray, A; Singh, N; Uhler, J, 2014) |
| "Rectal acetaminophen (Ac) is often administered prophylactically at anesthesia induction for postoperative pain management in small children and is thought to have an opioid-sparing effect." | 9.09 | Prophylactically-administered rectal acetaminophen does not reduce postoperative opioid requirements in infants and small children undergoing elective cleft palate repair. ( Behne, M; Bremerich, DH; Heimann, K; Kessler, P; Neidhart, G, 2001) |
| "A retrospective review of cleft palate cases over a 1-year period, 6 months with hemostatic pledgets, and 6 months with bupivacaine-soaked hemostatic pledgets." | 7.77 | Does use of bupivacaine-soaked pledgets aid in the care of postoperative cleft palate patients? ( Burstein, FD; Otterburn, DM, 2011) |
| "This prospective study looked at the postoperative hemorrhage risk associated with the use of diclofenac following cleft palate repair." | 7.70 | Diclofenac analgesia following cleft palate surgery. ( O'Neill, TJ; Sylaidis, P, 1998) |
| "Postoperative pain was assessed regularly with the Children Hospital of Eastern Ontario Pain Scale, and rescue analgesia was provided if scores were 7 or greater." | 6.76 | Effect of rectal diclofenac and acetaminophen alone and in combination on postoperative pain after cleft palate repair in children. ( Makarem, J; Mireskandari, SM, 2011) |
| " While the hepatotoxic effects of the drug have been well recognized in cases of acute overdose and chronic supratherapeutic doses, the toxic effects of acetaminophen are rarely documented in cases where therapeutic guidelines are followed." | 5.39 | Acute liver failure following cleft palate repair: a case of therapeutic acetaminophen toxicity. ( Boyajian, M; Cheerharan, M; Iorio, ML; Kaufman, SS; Reece-Stremtan, S, 2013) |
| "To assess opioid-sparing effects of oral or intravenous acetaminophen following primary cleft palate repair in children." | 5.19 | Analgesic effectiveness of acetaminophen for primary cleft palate repair in young children: a randomized placebo controlled trial. ( Applegate, RL; Hassanian, M; Martin, M; Mason, L; Nour, C; Ratsiu, J; Ray, A; Singh, N; Uhler, J, 2014) |
| "Rectal acetaminophen (Ac) is often administered prophylactically at anesthesia induction for postoperative pain management in small children and is thought to have an opioid-sparing effect." | 5.09 | Prophylactically-administered rectal acetaminophen does not reduce postoperative opioid requirements in infants and small children undergoing elective cleft palate repair. ( Behne, M; Bremerich, DH; Heimann, K; Kessler, P; Neidhart, G, 2001) |
| "This study aimed to determine whether intraoperative acetaminophen was able to decrease opioid consumption, pain scores, and length of stay while increasing oral intake in cleft palate surgery." | 3.88 | Opioid Sparing in Cleft Palate Surgery. ( Brgoch, M; Carr, L; Gray, M; Mackay, D; Morrow, B; Samson, T, 2018) |
| "Compared to acetaminophen, mothers reporting NSAIDs were significantly more likely to have offspring with gastroschisis, hypospadias, cleft palate, cleft lip with cleft palate, cleft lip without cleft palate, anencephaly, spina bifida, hypoplastic left heart syndrome, pulmonary valve stenosis, and tetralogy of Fallot (aOR range, 1." | 3.85 | Risk comparison for prenatal use of analgesics and selected birth defects, National Birth Defects Prevention Study 1997-2011. ( Ailes, EC; Anderka, M; Broussard, CS; Feldkamp, ML; Gilboa, SM; Interrante, JD; Lind, JN; Taylor, LG; Trinidad, J; Werler, MM, 2017) |
| "A retrospective review of cleft palate cases over a 1-year period, 6 months with hemostatic pledgets, and 6 months with bupivacaine-soaked hemostatic pledgets." | 3.77 | Does use of bupivacaine-soaked pledgets aid in the care of postoperative cleft palate patients? ( Burstein, FD; Otterburn, DM, 2011) |
| "This prospective study looked at the postoperative hemorrhage risk associated with the use of diclofenac following cleft palate repair." | 3.70 | Diclofenac analgesia following cleft palate surgery. ( O'Neill, TJ; Sylaidis, P, 1998) |
| "Postoperative pain was assessed regularly with the Children Hospital of Eastern Ontario Pain Scale, and rescue analgesia was provided if scores were 7 or greater." | 2.76 | Effect of rectal diclofenac and acetaminophen alone and in combination on postoperative pain after cleft palate repair in children. ( Makarem, J; Mireskandari, SM, 2011) |
| " The dosing recommendations of paracetamol may need to be reconsidered after cleft palate surgery." | 1.42 | Acute Liver Failure and Hepatic Encephalopathy After Cleft Palate Repair. ( Celebiler, O; Kocaaslan, ND; Tuncer, FB; Tutar, E, 2015) |
| " While the hepatotoxic effects of the drug have been well recognized in cases of acute overdose and chronic supratherapeutic doses, the toxic effects of acetaminophen are rarely documented in cases where therapeutic guidelines are followed." | 1.39 | Acute liver failure following cleft palate repair: a case of therapeutic acetaminophen toxicity. ( Boyajian, M; Cheerharan, M; Iorio, ML; Kaufman, SS; Reece-Stremtan, S, 2013) |
| "Acetaminophen pretreatment caused a threefold increase in phenytoin-induced fetal cleft palates without increasing resorptions." | 1.27 | Pharmacological studies on the potentiation of phenytoin teratogenicity by acetaminophen. ( Lum, JT; Wells, PG, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 9 (69.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Interrante, JD | 1 |
| Ailes, EC | 1 |
| Lind, JN | 1 |
| Anderka, M | 1 |
| Feldkamp, ML | 1 |
| Werler, MM | 1 |
| Taylor, LG | 1 |
| Trinidad, J | 1 |
| Gilboa, SM | 1 |
| Broussard, CS | 1 |
| Carr, L | 1 |
| Gray, M | 1 |
| Morrow, B | 1 |
| Brgoch, M | 1 |
| Mackay, D | 1 |
| Samson, T | 1 |
| Eason, HA | 1 |
| Perkins, R | 1 |
| Abdelrahman, M | 1 |
| Nour, C | 1 |
| Ratsiu, J | 1 |
| Singh, N | 1 |
| Mason, L | 1 |
| Ray, A | 1 |
| Martin, M | 1 |
| Hassanian, M | 1 |
| Uhler, J | 1 |
| Applegate, RL | 1 |
| Kocaaslan, ND | 1 |
| Tuncer, FB | 1 |
| Tutar, E | 1 |
| Celebiler, O | 1 |
| Binet, A | 1 |
| Poli-Merol, ML | 1 |
| François-Fiquet, C | 1 |
| Otterburn, DM | 1 |
| Burstein, FD | 1 |
| Mireskandari, SM | 1 |
| Makarem, J | 1 |
| Iorio, ML | 1 |
| Cheerharan, M | 1 |
| Kaufman, SS | 1 |
| Reece-Stremtan, S | 1 |
| Boyajian, M | 1 |
| Wells, PG | 2 |
| Sylaidis, P | 1 |
| O'Neill, TJ | 1 |
| Bremerich, DH | 1 |
| Neidhart, G | 1 |
| Heimann, K | 1 |
| Kessler, P | 1 |
| Behne, M | 1 |
| Lum, JT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-Blinded, Placebo Controlled Trial Using Single Dose Dexmedetomidine In The Treatment Of Pain In Patients Undergoing Cleft Palate Repair[NCT02915042] | Phase 4 | 0 participants (Actual) | Interventional | 2017-12-31 | Withdrawn (stopped due to Recruitment concerns) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for acetaminophen and Cleft Palate
| Article | Year |
|---|---|
Analgesic effectiveness of acetaminophen for primary cleft palate repair in young children: a randomized placebo controlled trial.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child, Preschool; Cleft Palate; Double-Blind Method; Female | 2014 |
Effect of rectal diclofenac and acetaminophen alone and in combination on postoperative pain after cleft palate repair in children.
Topics: Acetaminophen; Administration, Rectal; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Stero | 2011 |
Prophylactically-administered rectal acetaminophen does not reduce postoperative opioid requirements in infants and small children undergoing elective cleft palate repair.
Topics: Acetaminophen; Administration, Rectal; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Cle | 2001 |
10 other studies available for acetaminophen and Cleft Palate
| Article | Year |
|---|---|
Risk comparison for prenatal use of analgesics and selected birth defects, National Birth Defects Prevention Study 1997-2011.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Adult; Analgesics; Analgesics, Non-Narcotic; Analgesics, | 2017 |
Opioid Sparing in Cleft Palate Surgery.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Cleft Palate; Female; Humans; Infant; L | 2018 |
Survey of analgesia for cleft lip and palate repair in the UK and Republic of Ireland.
Topics: Acetaminophen; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Cleft Lip; Cleft Pala | 2014 |
Acute Liver Failure and Hepatic Encephalopathy After Cleft Palate Repair.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cleft Palate; Hepatic Encephalopathy; Humans; Infant; Liver | 2015 |
[Primary surgery for cleft palate and short hospital stay (48 h): Are they compatible?].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cleft Palate; Female; Humans; Infant; Length of Stay; Male; | 2016 |
Does use of bupivacaine-soaked pledgets aid in the care of postoperative cleft palate patients?
Topics: Acetaminophen; Administration, Topical; Anesthetics, Local; Bone Transplantation; Bupivacaine; Case- | 2011 |
Acute liver failure following cleft palate repair: a case of therapeutic acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Cleft Palate; Humans; Infusio | 2013 |
Physiological and environmental determinants of phenytoin teratogenicity: relation to glutathione homeostasis, and potentiation by acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Cleft Palate; Drug Synergism; Female; Fetal Resorption; Glut | 1983 |
Diclofenac analgesia following cleft palate surgery.
Topics: Acetaminophen; Administration, Rectal; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Stero | 1998 |
Pharmacological studies on the potentiation of phenytoin teratogenicity by acetaminophen.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Brain; Cleft Palate; Drug Synergism; Embryo Los | 1986 |