acetaminophen has been researched along with Chronic Illness in 171 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ibuprofen/paracetamol combination analgesia, at non-prescription doses, confers modest short-term benefits for knee pain/osteoarthritis." | 9.15 | A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain. ( Aspley, S; Doherty, M; Gibb, I; Goulder, M; Hawkey, C; Hill, N; Reader, S, 2011) |
| "This study compared the efficacy and safety of low-dose 7-day buprenorphine patches and prolonged-release tramadol tablets in patients with chronic, moderate to severe osteoarthritis (OA) pain of the hip and/or knee." | 9.14 | Efficacy and safety of low-dose transdermal buprenorphine patches (5, 10, and 20 microg/h) versus prolonged-release tramadol tablets (75, 100, 150, and 200 mg) in patients with chronic osteoarthritis pain: a 12-week, randomized, open-label, controlled, pa ( Berggren, AC; Karlsson, M, 2009) |
| "To evaluate the adequacy of a low-dose combination of oxycodone and paracetamol (acetaminophen) in patients with multimodal, chronic, non-malignant pain using the Pain Management Index (PMI)." | 9.14 | Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study. ( Bertini, L; Carucci, A; Gatti, A; Mammucari, M; Occhioni, R; Sabato, AF, 2009) |
| "To assess the efficacy and safety of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA; MS-sNT), which contain morphine sulfate pellets with a sequestered naltrexone core, in treating patients with chronic, moderate-to-severe osteoarthritis (hip or knee) pain." | 9.14 | Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain. ( Hale, M; Katz, N; Morris, D; Stauffer, J, 2010) |
| "This study compared the efficacy and safety profile of buprenorphine transdermal delivery system (BTDS) and placebo in subjects with persistent noncancer-related pain who required opioid analgesics." | 9.12 | Buprenorphine transdermal delivery system in adults with persistent noncancer-related pain syndromes who require opioid therapy: a multicenter, 5-week run-in and randomized, double-blind maintenance-of-analgesia study. ( Carr, WD; Landau, CJ; Munera, C; Razzetti, AJ; Ripa, SR; Sessler, NE, 2007) |
| "5 mg/acetaminophen 325 mg (tramadol/APAP) combination tablets for treatment of chronic low back pain (LBP)." | 9.11 | Analgesic efficacy and safety of tramadol/ acetaminophen combination tablets (Ultracet) in treatment of chronic low back pain: a multicenter, outpatient, randomized, double blind, placebo controlled trial. ( Beaulieu, A; Fortin, L; Kamin, M; Peloso, PM; Rosenthal, N, 2004) |
| "We hypothesised that the orally-active alpha(2)-adrenoceptor agonist lofexidine hydrochloride would ameliorate chronic pelvic pain in women." | 9.09 | Randomized placebo controlled trial of lofexidine hydrochloride for chronic pelvic pain in women. ( Anderson, D; Bradbury, L; Stones, RW, 2001) |
| "5 mg and ibuprofen 200 mg with that of combination codeine 30 mg and acetaminophen 300 mg for the treatment of chronic pain." | 9.09 | Combination hydrocodone and ibuprofen versus combination codeine and acetaminophen for the treatment of chronic pain. ( Damask, MJ; de Padova, A; Doyle, RT; Jiang, JG; Landau, CJ; Morris, E; Palangio, M, 2000) |
| "In a randomized, double-blind trial, 184 patients with chronic knee pain due to osteoarthritis were given either 2400 or 1200 mg of ibuprofen per day or 4000 mg of acetaminophen per day." | 9.07 | Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. ( Bradley, JD; Brandt, KD; Kalasinski, LA; Katz, BP; Ryan, SI, 1991) |
| "A double-blind, randomized, multicenter investigation was conducted to compare the efficacy and safety of Fioricet, acetaminophen with codeine, and placebo for the symptomatic treatment of tension headache." | 9.06 | Symptomatic treatment of chronically recurring tension headache: a placebo-controlled, multicenter investigation of Fioricet and acetaminophen with codeine. ( DiSerio, FJ; Friedman, AP, 1987) |
| "Thirty subjects with chronic moderate to severe pain who were receiving oxycodone/acetaminophen (oxy/APAP) for analgesia were initially evaluated for at least 7 days for oxy/APAP requirements for pain control." | 9.06 | The combination of ibuprofen and oxycodone/acetaminophen in the management of chronic cancer pain. ( Drew, J; Stambaugh, JE, 1988) |
| "This randomized, double-blind, multi-centre study was undertaken to evaluate the efficacy and safety of treatment for 4 weeks with codeine plus paracetamol versus paracetamol in relieving chronic pain due to osteoarthritis of the hip." | 9.06 | Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study. ( Andersen, HM; Branebjerg, PE; Gjøderum, O; Hvass, I; Kjærsgaard-Andersen, P; Krøner, K; Madsen, F; Nafei, A; Pedersen, L; Skov, O, 1990) |
| "A double-blind study was carried out in 90 patients with acute or chronic painful musculoskeletal conditions of at least moderate severity to compare the effectiveness over a 72-hour period of oral treatment, 3 to 6 hourly, with 200 mg meptazinol, 1 g paracetamol and placebo." | 9.05 | A double-blind comparison of meptazinol versus paracetamol and placebo in acute and chronic painful conditions presented to the general practitioner. ( Wade, AG; Ward, PJ, 1982) |
| "Acetaminophen (APAP) is a widely used medication in pregnancy and is considered safe." | 7.78 | Unintentional chronic acetaminophen poisoning during pregnancy resulting in liver transplantation. ( Minns, AB; Thornton, SL, 2012) |
| "Acetaminophen (APAP) is a popular analgesic." | 6.73 | Pharmacokinetics/pharmacodynamics of acetaminophen analgesia in Japanese patients with chronic pain. ( Aoyama, T; Aoyama, Y; Matsumoto, Y; Ohe, Y; Shinoda, S; Tomioka, S, 2007) |
| " Large patient-to-patient variations in pharmacokinetic parameters occurred, although intraindividual variability was limited." | 6.71 | Inter- and intraindividual variabilities in pharmacokinetics of fentanyl after repeated 72-hour transdermal applications in cancer pain patients. ( Bressolle, F; Caumette, L; Culine, S; Garcia, F; Pinguet, F; Poujol, S; Solassol, I, 2005) |
| "CR codeine treatment resulted in significantly lower overall VAS pain intensity scores (35 +/- 18 vs." | 6.68 | Efficacy of controlled-release codeine in chronic non-malignant pain: a randomized, placebo-controlled clinical trial. ( Arkinstall, W; Babul, N; Darke, AC; Goughnour, B; Harsanyi, Z; Sandler, A, 1995) |
| " After cross-reference searches of both trials and 38 reviews, seven studies comparing acetaminophen in continuous dosing regimens of more than 2 weeks with placebo were included." | 6.53 | Acetaminophen for Chronic Pain: A Systematic Review on Efficacy. ( Dideriksen, D; Ennis, ZN; Handberg, G; Pottegård, A; Vaegter, HB, 2016) |
| "Acetaminophen is a safe medication that should be considered first-line therapy." | 6.44 | Approach to managing musculoskeletal pain: acetaminophen, cyclooxygenase-2 inhibitors, or traditional NSAIDs? ( Choquette, D; Craig, BN; Davis, P; De Angelis, C; Fulthorpe, G; Habal, F; Hunt, RH; Stewart, JI; Turpie, AG, 2007) |
| "Valdecoxib also has superior gastrointestinal safety compared with nonspecific nonsteroidal anti-inflammatory drugs, and at therapeutic doses, it is generally safe and well tolerated in terms of renal and cardiovascular events." | 6.43 | Valdecoxib for the management of chronic and acute pain. ( Joshi, GP, 2005) |
| " We sought to evaluate the effectiveness and safety of over the counter dosing of ibuprofen on pain and bleeding rates following ESS." | 5.56 | Effect of Over the Counter Ibuprofen Dosing after Sinus Surgery for Chronic Rhinosinusitis: A Prospective Cohort Pilot Study. ( Davis, GE; Humphreys, IM; Miller, C, 2020) |
| "Acetaminophen is a widely used antipyretic drug." | 5.33 | Churg-Strauss syndrome associated with hypersensitivity to acetaminophen. ( Kawakami, M; Masuzawa, A; Moriguchi, M; Otsuka, M; Sugawara, H; Tabei, K; Tsuda, T; Yamada, S, 2005) |
| "Ibuprofen/paracetamol combination analgesia, at non-prescription doses, confers modest short-term benefits for knee pain/osteoarthritis." | 5.15 | A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain. ( Aspley, S; Doherty, M; Gibb, I; Goulder, M; Hawkey, C; Hill, N; Reader, S, 2011) |
| "To assess the efficacy and safety of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA; MS-sNT), which contain morphine sulfate pellets with a sequestered naltrexone core, in treating patients with chronic, moderate-to-severe osteoarthritis (hip or knee) pain." | 5.14 | Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain. ( Hale, M; Katz, N; Morris, D; Stauffer, J, 2010) |
| "This study compared the efficacy and safety of low-dose 7-day buprenorphine patches and prolonged-release tramadol tablets in patients with chronic, moderate to severe osteoarthritis (OA) pain of the hip and/or knee." | 5.14 | Efficacy and safety of low-dose transdermal buprenorphine patches (5, 10, and 20 microg/h) versus prolonged-release tramadol tablets (75, 100, 150, and 200 mg) in patients with chronic osteoarthritis pain: a 12-week, randomized, open-label, controlled, pa ( Berggren, AC; Karlsson, M, 2009) |
| "To evaluate the adequacy of a low-dose combination of oxycodone and paracetamol (acetaminophen) in patients with multimodal, chronic, non-malignant pain using the Pain Management Index (PMI)." | 5.14 | Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study. ( Bertini, L; Carucci, A; Gatti, A; Mammucari, M; Occhioni, R; Sabato, AF, 2009) |
| "This study compared the efficacy and safety profile of buprenorphine transdermal delivery system (BTDS) and placebo in subjects with persistent noncancer-related pain who required opioid analgesics." | 5.12 | Buprenorphine transdermal delivery system in adults with persistent noncancer-related pain syndromes who require opioid therapy: a multicenter, 5-week run-in and randomized, double-blind maintenance-of-analgesia study. ( Carr, WD; Landau, CJ; Munera, C; Razzetti, AJ; Ripa, SR; Sessler, NE, 2007) |
| "5 mg/acetaminophen 325 mg (tramadol/APAP) combination tablets for treatment of chronic low back pain (LBP)." | 5.11 | Analgesic efficacy and safety of tramadol/ acetaminophen combination tablets (Ultracet) in treatment of chronic low back pain: a multicenter, outpatient, randomized, double blind, placebo controlled trial. ( Beaulieu, A; Fortin, L; Kamin, M; Peloso, PM; Rosenthal, N, 2004) |
| "5 mg and ibuprofen 200 mg with that of combination codeine 30 mg and acetaminophen 300 mg for the treatment of chronic pain." | 5.09 | Combination hydrocodone and ibuprofen versus combination codeine and acetaminophen for the treatment of chronic pain. ( Damask, MJ; de Padova, A; Doyle, RT; Jiang, JG; Landau, CJ; Morris, E; Palangio, M, 2000) |
| "12-week within-patient, randomised, double-blind, placebo-controlled, crossover comparison of ibuprofen with paracetamol for osteoarthritis, involving three pairs of two-week treatment periods for each participating patient." | 5.09 | Preliminary experiences with a single-patient trials service in general practice. ( Clavarino, A; Del Mar, CB; Duggan, CM; Glasziou, PP; Nikles, CJ; Yelland, MJ, 2000) |
| "We hypothesised that the orally-active alpha(2)-adrenoceptor agonist lofexidine hydrochloride would ameliorate chronic pelvic pain in women." | 5.09 | Randomized placebo controlled trial of lofexidine hydrochloride for chronic pelvic pain in women. ( Anderson, D; Bradbury, L; Stones, RW, 2001) |
| " We analyzed gastric emptying and hormonal adaptation of cholecystokinin (CCK), pancreatic polypeptide (PP), and gastrin following two surgical procedures for chronic pancreatitis (CP): the PPW and the duodenum-preserving pancreatic head resection (DPPHR)." | 5.08 | Gastric emptying following pylorus-preserving Whipple and duodenum-preserving pancreatic head resection in patients with chronic pancreatitis. ( Beger, HG; Büchler, MW; Friess, H; Glasbrenner, B; Kleeff, J; Lauterburg, B; Müller, MW; Riepl, RL, 1997) |
| "In a randomized, double-blind trial, 184 patients with chronic knee pain due to osteoarthritis were given either 2400 or 1200 mg of ibuprofen per day or 4000 mg of acetaminophen per day." | 5.07 | Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. ( Bradley, JD; Brandt, KD; Kalasinski, LA; Katz, BP; Ryan, SI, 1991) |
| "A double-blind, randomized, multicenter investigation was conducted to compare the efficacy and safety of Fioricet, acetaminophen with codeine, and placebo for the symptomatic treatment of tension headache." | 5.06 | Symptomatic treatment of chronically recurring tension headache: a placebo-controlled, multicenter investigation of Fioricet and acetaminophen with codeine. ( DiSerio, FJ; Friedman, AP, 1987) |
| "Thirty subjects with chronic moderate to severe pain who were receiving oxycodone/acetaminophen (oxy/APAP) for analgesia were initially evaluated for at least 7 days for oxy/APAP requirements for pain control." | 5.06 | The combination of ibuprofen and oxycodone/acetaminophen in the management of chronic cancer pain. ( Drew, J; Stambaugh, JE, 1988) |
| "This randomized, double-blind, multi-centre study was undertaken to evaluate the efficacy and safety of treatment for 4 weeks with codeine plus paracetamol versus paracetamol in relieving chronic pain due to osteoarthritis of the hip." | 5.06 | Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study. ( Andersen, HM; Branebjerg, PE; Gjøderum, O; Hvass, I; Kjærsgaard-Andersen, P; Krøner, K; Madsen, F; Nafei, A; Pedersen, L; Skov, O, 1990) |
| "Patients with osteoarthritis were entered into a single-blind trial comparing the effects on the gastric mucosa of a four week course of indomethacin, sulindac and a compound of paracetamol and dextropropoxyphene (Distalgesic)." | 5.05 | Histological study of the effects of three anti-inflammatory preparations on the gastric mucosa. ( Irani, MS; McIntyre, RL; Piris, J, 1981) |
| "A double-blind study was carried out in 90 patients with acute or chronic painful musculoskeletal conditions of at least moderate severity to compare the effectiveness over a 72-hour period of oral treatment, 3 to 6 hourly, with 200 mg meptazinol, 1 g paracetamol and placebo." | 5.05 | A double-blind comparison of meptazinol versus paracetamol and placebo in acute and chronic painful conditions presented to the general practitioner. ( Wade, AG; Ward, PJ, 1982) |
| "The objective of this study was to assess the efficacy of paracetamol (acetaminophen) in the treatment of pain and disability in patients with non-specific low back pain." | 4.84 | A systematic review of paracetamol for non-specific low back pain. ( Davies, RA; Hancock, MJ; Maher, CG, 2008) |
| "To assess benefits and harms of acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), antidepressants, benzodiazepines, antiepileptic drugs, skeletal muscle relaxants, opioid analgesics, tramadol, and systemic corticosteroids for acute or chronic low back pain (with or without leg pain)." | 4.84 | Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. ( Chou, R; Huffman, LH, 2007) |
| "Though all non-narcotic analgesics have equivalent efficacy against tension-type headache, ibuprofen's generally favorable side-effect profile makes it a reasonable first choice." | 4.83 | Is any one analgesic superior for episodic tension-type headache? ( Berger, MY; Damen, L; Koes, BW; Merlijn, V; Passchier, J; Verhagen, AP, 2006) |
| " After acetaminophen intoxication, necrosis was significantly increased in TAFI-/- mice at 24 hours (h) after injection." | 3.79 | TAFI deficiency promotes liver damage in murine models of liver failure through defective down-regulation of hepatic inflammation. ( Adelmeijer, J; Hugenholtz, GC; Lisman, T; Meijers, JC; Porte, RJ, 2013) |
| "Acetaminophen (APAP) is a widely used medication in pregnancy and is considered safe." | 3.78 | Unintentional chronic acetaminophen poisoning during pregnancy resulting in liver transplantation. ( Minns, AB; Thornton, SL, 2012) |
| " These disturbances are often associated with acetaminophen in the setting of certain risk factors such as sepsis, malnutrition, liver disease, female gender, pregnancy or renal failure." | 3.78 | Chronic acetaminophen ingestion resulting in severe anion gap metabolic acidosis secondary to 5-oxoproline accumulation: an under diagnosed phenomenon. ( Flemmer, M; Hooper, M; Marik, PE; O'Brien, LM, 2012) |
| " Similarly, Fah(-/-) animals with liver injury were also resistant to apoptosis induced by the Fas ligand Jo-2 and to necrosis-like cell death induced by acetaminophen (APAP)." | 3.72 | Chronic liver disease in murine hereditary tyrosinemia type 1 induces resistance to cell death. ( Al-Dhalimy, M; Finegold, M; Grompe, M; Groopman, J; Iordanov, MS; Ou, CN; Ryabinina, O; van Den Berg, IE; Vogel, A, 2004) |
| "In spite of clinical differences between transformed migraine and tension headache, which may help diagnosis, in our series abuse of analgesics (including ergotamine) was a common characteristic." | 3.69 | [Clinical features of daily chronic headache]. ( Iñiguez, C; Larrodé, P; Mauri, JA; Morales, F, 1997) |
| "The plasma half lives of antipyrine, paracetamol, and lignocaine given by mouth were measured in 23 patients with stable chronic liver diseases of varying severity." | 3.65 | Antipyrine, paracetamol, and lignocaine elimination in chronic liver disease. ( Adjepon-Yamoah, KK; Finlayson, ND; Forrest, JA; Prescott, LF, 1977) |
| "Celecoxib is a cyclooxygenase-2-specific inhibitor indicated to treat acute pain and pain secondary to osteoarthritis and rheumatoid arthritis." | 2.82 | Celecoxib Versus Placebo in Tonsillectomy: A Prospective, Randomized, Double-Blind Placebo-Controlled Trial. ( Bodeker, KL; Trask, DK; Van Daele, DJ, 2016) |
| "We sought to study postoperative pain after endoscopic sinus surgery and to evaluate the efficacy of dexamethasone sodium phosphate in reducing pain and rescue analgesic requirements." | 2.75 | Role of dexamethasone in reducing pain after endoscopic sinus surgery in adults: a double-blind prospective randomized trial. ( Al-Qudah, M; Rashdan, Y, 2010) |
| "Ketamine has been shown to have a morphine-sparing effect soon after surgery." | 2.74 | The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study. ( Baud, A; Couvret, C; Favard, L; Fusciardi, J; Laffon, M; Le Tendre, C; Pourrat, X; Remérand, F, 2009) |
| "Low back pain is a highly common problem and causes much morbidity and socioeconomic loss in the community." | 2.73 | Caudal epidural injection versus non-steroidal anti-inflammatory drugs in the treatment of low back pain accompanied with radicular pain. ( Cakar, E; Dincer, U; Dursan, H; Kiralp, MZ; Yasar, E, 2007) |
| "Acetaminophen (APAP) is a popular analgesic." | 2.73 | Pharmacokinetics/pharmacodynamics of acetaminophen analgesia in Japanese patients with chronic pain. ( Aoyama, T; Aoyama, Y; Matsumoto, Y; Ohe, Y; Shinoda, S; Tomioka, S, 2007) |
| "ESS is associated with significant postoperative pain." | 2.72 | Acetaminophen is highly effective in pain treatment after endoscopic sinus surgery. ( Kemppainen, T; Kokki, H; Nuutinen, J; Seppä, J; Tuomilehto, H, 2006) |
| " Large patient-to-patient variations in pharmacokinetic parameters occurred, although intraindividual variability was limited." | 2.71 | Inter- and intraindividual variabilities in pharmacokinetics of fentanyl after repeated 72-hour transdermal applications in cancer pain patients. ( Bressolle, F; Caumette, L; Culine, S; Garcia, F; Pinguet, F; Poujol, S; Solassol, I, 2005) |
| "Patients with at least moderate lower back pain (pain visual analog [PVA] score >/=40 mm on a 100-mm scale) were randomized to receive up to 8 tablets of tramadol/APAP per day or placebo for 91 days." | 2.71 | Tramadol/acetaminophen combination tablets for the treatment of chronic lower back pain: a multicenter, randomized, double-blind, placebo-controlled outpatient study. ( Jordan, D; Kamin, M; Karim, R; Rosenthal, N; Ruoff, GE, 2003) |
| "In conclusion, alloPBSCT in ANLL is associated with a faster engraftment, no greater incidence of AGVHD, but increased risk of CGVHD." | 2.69 | Allogeneic peripheral blood stem cell transplantation in acute non-lymphoblastic leukemia. ( Akan, H; Arat, M; Arslan, O; Beksaç, M; Celebi, H; Gürman, G; Ilhan, O; Koç, H; Konuk, N; Ozcan, M; Ustün, C; Uysal, A, 1998) |
| "CR codeine treatment resulted in significantly lower overall VAS pain intensity scores (35 +/- 18 vs." | 2.68 | Efficacy of controlled-release codeine in chronic non-malignant pain: a randomized, placebo-controlled clinical trial. ( Arkinstall, W; Babul, N; Darke, AC; Goughnour, B; Harsanyi, Z; Sandler, A, 1995) |
| " The absolute bioavailability of frusemide during hypoxaemia (0." | 2.68 | The effect of hypoxaemia on drug disposition in chronic respiratory failure. ( Hayball, PJ; Henderson, G; Latimer, K; May, F; Rowett, D; Ruffin, RE; Sansom, LN, 1996) |
| " Tolerance in terms of withdrawals or side-effect profile did not appear to the dosage of each preparation administered." | 2.67 | The efficacy and tolerability of controlled-release dihydrocodeine tablets and combination dextropropoxyphene/paracetamol tablets in patients with severe osteoarthritis of the hips. ( Costello, F; Eves, MJ; James, IG; Lloyd, RS; Miller, AJ, 1992) |
| " The level of certainty for dosing recommendations obtainable from reviewing the evidence is low due to a small number of studies meeting search criteria, small samples sizes, inadequate information regarding cirrhosis etiology and compensated versus uncompensated liver disease, and lack of information on patient centered health outcomes." | 2.58 | A Systematic Review of the Evidence Behind Use of Reduced Doses of Acetaminophen in Chronic Liver Disease. ( Juba, KM; Schweighardt, AE, 2018) |
| " After cross-reference searches of both trials and 38 reviews, seven studies comparing acetaminophen in continuous dosing regimens of more than 2 weeks with placebo were included." | 2.53 | Acetaminophen for Chronic Pain: A Systematic Review on Efficacy. ( Dideriksen, D; Ennis, ZN; Handberg, G; Pottegård, A; Vaegter, HB, 2016) |
| "Although 60 years have passed since it became widely available on the therapeutic market, paracetamol dosage in patients with liver disease remains a controversial subject." | 2.53 | Can paracetamol (acetaminophen) be administered to patients with liver impairment? ( Hayward, KL; Irvine, KM; Martin, JH; Powell, EE, 2016) |
| "The TACs include cluster headache, paroxysmal hemicrania, and short-lasting neuralgiform headache attacks with conjunctival injection and tearing; hemicrania continua, although classified separately by the International Headache Society, shares many features of both migraine and the TACs." | 2.49 | Primary headache disorders. ( Benoliel, R; Eliav, E, 2013) |
| " Subanaesthetic doses of ketamine have an opioid-sparing effect, but the optimal dosing regimen is uncertain." | 2.47 | [Post-operative pain management in hospitals]. ( Borchgrevink, PC; Fredheim, OM; Kvarstein, G, 2011) |
| "Acetaminophen is a safe medication that should be considered first-line therapy." | 2.44 | Approach to managing musculoskeletal pain: acetaminophen, cyclooxygenase-2 inhibitors, or traditional NSAIDs? ( Choquette, D; Craig, BN; Davis, P; De Angelis, C; Fulthorpe, G; Habal, F; Hunt, RH; Stewart, JI; Turpie, AG, 2007) |
| "The prevalences of complex regional pain syndrome, phantom limb pain, chronic donor-site pain, and persistent pain following total joint arthroplasty are alarmingly high." | 2.44 | Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques. ( Buvanendran, A; Reuben, SS, 2007) |
| "Valdecoxib also has superior gastrointestinal safety compared with nonspecific nonsteroidal anti-inflammatory drugs, and at therapeutic doses, it is generally safe and well tolerated in terms of renal and cardiovascular events." | 2.43 | Valdecoxib for the management of chronic and acute pain. ( Joshi, GP, 2005) |
| "Chronic pain has a growing incidence with age." | 2.43 | [Management strategies for the treatment of non malignant chronic pain in the elderly]. ( Perrot, S, 2006) |
| "Codeine is an opiate with uncertain and unpredictable effects." | 2.42 | [Problem forte--is paracetamol-codeine combination rational?]. ( Helland, A; Slørdal, L; Spigset, O, 2004) |
| ") After initiating morphine or making any change of dose or route of administration, the dosage should be evaluated after approximately 24 hours." | 2.40 | The management of chronic pain in patients with breast cancer. The Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer. Canadian Society of Palliative Care Physicians. Canadian Association of Radiation Oncologist ( , 1998) |
| " In a double-blind, two-week, cross-over study, no clinical or laboratory evidence of adverse effects was found." | 2.36 | Hepatotoxicity following the therapeutic use of antipyretic analgesics. ( Benson, GD, 1983) |
| "At baseline, mean monthly migraine days were 9." | 1.62 | Understanding the migraine treatment landscape prior to the introduction of calcitonin gene-related peptide inhibitors: Results from the Assessment of TolerabiliTy and Effectiveness in MigrAINe Patients using Preventive Treatment (ATTAIN) study. ( Dodick, DW; Kawata, AK; Lipton, RB; Poon, JL; Sapra, S; Shaffer, S; Shah, N; Shah, S; Tepper, SJ; Wilcox, TK, 2021) |
| " We sought to evaluate the effectiveness and safety of over the counter dosing of ibuprofen on pain and bleeding rates following ESS." | 1.56 | Effect of Over the Counter Ibuprofen Dosing after Sinus Surgery for Chronic Rhinosinusitis: A Prospective Cohort Pilot Study. ( Davis, GE; Humphreys, IM; Miller, C, 2020) |
| "Headache is a common chronic neurologic disorder with huge economic and psychosocial impact." | 1.46 | Prevalence and clinical characteristics of headaches among undergraduate students in three tertiary institutions in Ilorin, Nigeria. ( Aderibigbe, SA; Adeyanju, OA; Desalu, OO; Kolo, PM; Mustapha, AF; Sanya, EO, 2017) |
| "However, elderly people with chronic pain rarely used the medications specifically for neuropathic pain." | 1.43 | Chronic pain among community-dwelling elderly: a population-based clinical study. ( Haanpää, M; Liira, H; Rapo-Pylkkö, S, 2016) |
| "Glucose metabolic changes in CM patients taking different dosage of analgesic during headache-free periods and clear distinctions in several brain regions were observed." | 1.39 | Overuse of paracetamol caffeine aspirin powders affects cerebral glucose metabolism in chronic migraine patients. ( Di, W; Fang, Y; Luo, N; Miao, J; Qi, W; Shi, X; Tao, Y; Xiao, Z; Yi, C; Zhang, A; Zhang, X; Zhu, Y, 2013) |
| "Anxiety and depression are often also present." | 1.35 | Fibromyalgia: poorly understood; treatments are disappointing. ( , 2009) |
| "Chronic constipation is associated with use of acetaminophen, aspirin and non-steroidal anti-inflammatory drugs." | 1.34 | Risk factors for chronic constipation and a possible role of analgesics. ( Chang, JY; Locke, GR; Schleck, CD; Talley, NJ; Zinsmeister, AR, 2007) |
| " Following dosing of CFA-injected rats with rofecoxib (Vioxx) or paracetamol, there was a significant decrease in the number of ipsilateral CGRP-IR small and medium DRG neurones in rofecoxib- but not paracetamol-treated rats." | 1.34 | Changes in dorsal root ganglion CGRP expression in a chronic inflammatory model of the rat knee joint: differential modulation by rofecoxib and paracetamol. ( Bountra, C; Chessell, IP; Day, NC; Staton, PC; Wilson, AW, 2007) |
| "Acetaminophen is a widely used antipyretic drug." | 1.33 | Churg-Strauss syndrome associated with hypersensitivity to acetaminophen. ( Kawakami, M; Masuzawa, A; Moriguchi, M; Otsuka, M; Sugawara, H; Tabei, K; Tsuda, T; Yamada, S, 2005) |
| "The mean Cmax of 11." | 1.33 | The pharmacokinetics of a single rectal dose of paracetamol (40 mg x kg(-1)) in children with liver disease. ( Addison, R; Ashley, EM; Cormack, CR; Howell, T; Keating, J; Sherwood, RA; Sudan, S, 2006) |
| "Paracetamol is regarded as a relatively safe drug in the gastro-duodenal region of humans but recent epidemiological investigations have suggested that at high doses there may be an increased risk of ulcers and bleeding." | 1.33 | Paracetamol [acetaminophen]-induced gastrotoxicity: revealed by induced hyperacidity in combination with acute or chronic inflammation. ( Rainsford, KD; Whitehouse, MW, 2006) |
| "Colitis was induced in rats by an enema containing 2,4,6-trinitrobenzen sulfonic acid." | 1.32 | Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats. ( Ardid, D; Eschalier, A; Etienne, M; Jourdan, D; Millecamps, M, 2004) |
| "In aggregate, 2195 patients (31% with cancer diagnoses per the International Classification of Diseases, Ninth Revision, Clinical Modification) received oxycodone/acetaminophen for more than 9 months at a mean prescribed daily dose of 3." | 1.32 | Characterizations of long-term oxycodone/acetaminophen prescriptions in veteran patients. ( Fiore, LD; Gagnon, DR; Hermos, JA; Young, MM, 2004) |
| "This was a prospective case series of consecutive patients aged 12 years and older with acetaminophen dosage greater than 4 g per 24 hours referred to our poison center." | 1.32 | Prospective evaluation of repeated supratherapeutic acetaminophen (paracetamol) ingestion. ( Bogdan, GM; Daly, FF; Dart, RC; Heard, K; O'Malley, GF, 2004) |
| "Acetaminophen is a common cause of poisoning in children." | 1.31 | Is chronic poisoning with acetaminophen in children a frequent occurrence in Toronto? ( Bailey, B; Kapur, BM; Koren, G; Lalkin, A, 2001) |
| "We report a case fatality from chronic acetaminophen (APAP) toxicity in an 18-month-old toddler, born 14 weeks premature, who had been receiving less than the standard toxic threshold of the pediatric suspension of APAP for 4 days prior to presentation." | 1.30 | "The silent killer": chronic acetaminophen toxicity in a toddler. ( King, W; Nichols, M; Pershad, J, 1999) |
| " Incidence of side effects and toxicity may be reduced by choice of drug and modification of dosing regimen." | 1.28 | Nonnarcotic analgesics and tricyclic antidepressants for the treatment of chronic nonmalignant pain. ( Richlin, DM, 1991) |
| " We conclude that, although propranolol may have some influence on drug handling acutely, chronic administration does not interfere with hepatic drug metabolism or renal drug clearance." | 1.28 | Effect of acute and chronic propranolol administration on antipyrine and paracetamol clearance in patients with chronic liver disease. ( Bouchier, IA; Hayes, PC, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (18.13) | 18.7374 |
| 1990's | 31 (18.13) | 18.2507 |
| 2000's | 70 (40.94) | 29.6817 |
| 2010's | 36 (21.05) | 24.3611 |
| 2020's | 3 (1.75) | 2.80 |
| Authors | Studies |
|---|---|
| Shinoda, S | 1 |
| Aoyama, T | 1 |
| Aoyama, Y | 1 |
| Tomioka, S | 1 |
| Matsumoto, Y | 1 |
| Ohe, Y | 1 |
| Miller, C | 1 |
| Humphreys, IM | 1 |
| Davis, GE | 1 |
| Rizvi, F | 1 |
| Everton, E | 1 |
| Smith, AR | 1 |
| Liu, H | 1 |
| Osota, E | 1 |
| Beattie, M | 1 |
| Tam, Y | 1 |
| Pardi, N | 1 |
| Weissman, D | 1 |
| Gouon-Evans, V | 1 |
| Kawata, AK | 1 |
| Shah, N | 1 |
| Poon, JL | 1 |
| Shaffer, S | 1 |
| Sapra, S | 1 |
| Wilcox, TK | 1 |
| Shah, S | 1 |
| Tepper, SJ | 1 |
| Dodick, DW | 1 |
| Lipton, RB | 1 |
| Sanya, EO | 1 |
| Desalu, OO | 1 |
| Aderibigbe, SA | 1 |
| Kolo, PM | 1 |
| Mustapha, AF | 1 |
| Adeyanju, OA | 1 |
| Büker, C | 1 |
| Rotunno, A | 1 |
| Schwellnus, MP | 1 |
| Swanevelder, S | 1 |
| Jordaan, E | 1 |
| Janse Van Rensburg, DC | 1 |
| Derman, W | 1 |
| Mashally, S | 1 |
| Nield, LE | 1 |
| McNamara, PJ | 1 |
| Martins, FF | 1 |
| El-Khuffash, A | 1 |
| Jain, A | 1 |
| Weisz, DE | 1 |
| Schweighardt, AE | 1 |
| Juba, KM | 1 |
| Pitman, A | 1 |
| Tham, SG | 1 |
| Hunt, IM | 1 |
| Webb, RT | 1 |
| Appleby, L | 1 |
| Kapur, N | 1 |
| Hugenholtz, GC | 1 |
| Meijers, JC | 1 |
| Adelmeijer, J | 1 |
| Porte, RJ | 1 |
| Lisman, T | 1 |
| Benoliel, R | 1 |
| Eliav, E | 1 |
| Asero, R | 2 |
| Feng, D | 1 |
| Wang, Y | 1 |
| Wang, H | 1 |
| Weng, H | 1 |
| Kong, X | 1 |
| Martin-Murphy, BV | 1 |
| Li, Y | 1 |
| Park, O | 1 |
| Dooley, S | 1 |
| Ju, C | 1 |
| Gao, B | 1 |
| Bellei, E | 1 |
| Monari, E | 1 |
| Bergamini, S | 1 |
| Cuoghi, A | 1 |
| Tomasi, A | 1 |
| Guerzoni, S | 1 |
| Ciccarese, M | 1 |
| Pini, LA | 1 |
| Hayward, KL | 1 |
| Powell, EE | 1 |
| Irvine, KM | 1 |
| Martin, JH | 1 |
| Ennis, ZN | 1 |
| Dideriksen, D | 1 |
| Vaegter, HB | 1 |
| Handberg, G | 1 |
| Pottegård, A | 1 |
| Rapo-Pylkkö, S | 1 |
| Haanpää, M | 1 |
| Liira, H | 1 |
| Van Daele, DJ | 1 |
| Bodeker, KL | 1 |
| Trask, DK | 1 |
| Tong, HY | 1 |
| Medrano, N | 1 |
| Borobia, AM | 1 |
| Ruiz, JA | 1 |
| Martínez, AM | 1 |
| Martín, J | 1 |
| Quintana, M | 1 |
| García, S | 1 |
| Carcas, AJ | 1 |
| Ramírez, E | 1 |
| Mattia, C | 1 |
| Coluzzi, F | 1 |
| Sarzi Puttini, P | 1 |
| Viganó, R | 1 |
| Apgar, BS | 1 |
| Davies, RA | 1 |
| Maher, CG | 1 |
| Hancock, MJ | 1 |
| Karlsson, M | 1 |
| Berggren, AC | 1 |
| Gatti, A | 2 |
| Sabato, AF | 2 |
| Carucci, A | 1 |
| Bertini, L | 1 |
| Mammucari, M | 2 |
| Occhioni, R | 1 |
| Bruehl, S | 1 |
| Chung, OY | 1 |
| Chont, M | 1 |
| Remérand, F | 1 |
| Le Tendre, C | 1 |
| Baud, A | 1 |
| Couvret, C | 1 |
| Pourrat, X | 1 |
| Favard, L | 1 |
| Laffon, M | 1 |
| Fusciardi, J | 1 |
| Al-Qudah, M | 1 |
| Rashdan, Y | 1 |
| Clarke, H | 1 |
| Kay, J | 1 |
| Mitsakakis, N | 1 |
| Katz, J | 1 |
| Katz, N | 1 |
| Hale, M | 1 |
| Morris, D | 1 |
| Stauffer, J | 1 |
| Supornsilpchai, W | 1 |
| le Grand, SM | 1 |
| Srikiatkhachorn, A | 1 |
| Williams, BS | 1 |
| Wong, D | 1 |
| Amin, S | 1 |
| Sabato, E | 1 |
| Masucci, L | 1 |
| Hey, M | 1 |
| Wilson, I | 1 |
| Johnson, MI | 1 |
| Schoeman, S | 1 |
| Sommer, S | 1 |
| Monteiro, EF | 1 |
| Latthe, PM | 1 |
| Champaneria, R | 1 |
| Khan, KS | 1 |
| Doherty, M | 1 |
| Hawkey, C | 1 |
| Goulder, M | 1 |
| Gibb, I | 1 |
| Hill, N | 1 |
| Aspley, S | 1 |
| Reader, S | 1 |
| Barkin, RL | 1 |
| Barkin, SJ | 1 |
| Irving, GA | 1 |
| Gordon, A | 1 |
| Fredheim, OM | 1 |
| Borchgrevink, PC | 1 |
| Kvarstein, G | 1 |
| Bannon, M | 1 |
| Pach, D | 1 |
| Brinkhaus, B | 1 |
| Roll, S | 1 |
| Wegscheider, K | 1 |
| Icke, K | 1 |
| Willich, SN | 1 |
| Witt, CM | 1 |
| Thornton, SL | 1 |
| Minns, AB | 1 |
| Obel, G | 1 |
| Krogdahl, A | 1 |
| Thygesen, T | 1 |
| Godballe, C | 1 |
| O'Brien, LM | 1 |
| Hooper, M | 1 |
| Flemmer, M | 1 |
| Marik, PE | 1 |
| Bennadji, B | 1 |
| Desramé, J | 1 |
| de Parades, V | 1 |
| Di, W | 1 |
| Shi, X | 1 |
| Zhu, Y | 1 |
| Tao, Y | 1 |
| Qi, W | 1 |
| Luo, N | 1 |
| Xiao, Z | 1 |
| Yi, C | 1 |
| Miao, J | 1 |
| Zhang, A | 1 |
| Zhang, X | 1 |
| Fang, Y | 1 |
| Mortensen, ME | 1 |
| Cullen, JL | 1 |
| Berde, CB | 1 |
| Sethna, NF | 1 |
| McClellan, K | 1 |
| Scott, LJ | 1 |
| Ruoff, GE | 1 |
| Rosenthal, N | 2 |
| Jordan, D | 1 |
| Karim, R | 1 |
| Kamin, M | 2 |
| Gordon, DB | 1 |
| Graham, GG | 1 |
| Scott, KF | 1 |
| Day, RO | 1 |
| Vogel, A | 1 |
| van Den Berg, IE | 1 |
| Al-Dhalimy, M | 1 |
| Groopman, J | 1 |
| Ou, CN | 1 |
| Ryabinina, O | 1 |
| Iordanov, MS | 1 |
| Finegold, M | 1 |
| Grompe, M | 1 |
| Kubuschok, B | 1 |
| Xie, X | 1 |
| Jesnowski, R | 1 |
| Preuss, KD | 1 |
| Romeike, BF | 1 |
| Neumann, F | 1 |
| Regitz, E | 1 |
| Pistorius, G | 1 |
| Schilling, M | 1 |
| Scheunemann, P | 1 |
| Izbicki, JR | 1 |
| Löhr, JM | 1 |
| Pfreundschuh, M | 1 |
| Feldt, KS | 1 |
| Millecamps, M | 2 |
| Etienne, M | 2 |
| Jourdan, D | 2 |
| Eschalier, A | 2 |
| Ardid, D | 2 |
| Helland, A | 1 |
| Spigset, O | 1 |
| Slørdal, L | 1 |
| Daly, FF | 1 |
| O'Malley, GF | 1 |
| Heard, K | 1 |
| Bogdan, GM | 1 |
| Dart, RC | 1 |
| Brooks, DE | 1 |
| Yealy, DM | 1 |
| Hermos, JA | 1 |
| Young, MM | 1 |
| Gagnon, DR | 1 |
| Fiore, LD | 1 |
| Atkinson, JH | 1 |
| Peloso, PM | 1 |
| Fortin, L | 1 |
| Beaulieu, A | 1 |
| White, P | 1 |
| Lewith, G | 1 |
| Prescott, P | 1 |
| Conway, J | 1 |
| Liu, YP | 1 |
| Fang, CC | 1 |
| Chen, WJ | 1 |
| Ni, YH | 1 |
| Czeizel, AE | 1 |
| Dudás, I | 1 |
| Puhó, E | 1 |
| Joshi, GP | 1 |
| Hämäläinen, M | 1 |
| Masuzawa, A | 1 |
| Moriguchi, M | 1 |
| Tsuda, T | 1 |
| Sugawara, H | 1 |
| Otsuka, M | 1 |
| Yamada, S | 1 |
| Tabei, K | 1 |
| Kawakami, M | 1 |
| Solassol, I | 1 |
| Bressolle, F | 1 |
| Caumette, L | 1 |
| Garcia, F | 1 |
| Poujol, S | 1 |
| Culine, S | 1 |
| Pinguet, F | 1 |
| Leger, S | 1 |
| McKinney, J | 1 |
| Garcin, M | 1 |
| Mille-Hamard, L | 1 |
| Billat, V | 1 |
| Imbenotte, M | 1 |
| Humbert, L | 1 |
| Lhermitte, Z | 1 |
| Cormack, CR | 1 |
| Sudan, S | 1 |
| Addison, R | 1 |
| Keating, J | 1 |
| Sherwood, RA | 1 |
| Ashley, EM | 1 |
| Howell, T | 1 |
| Staton, PC | 1 |
| Wilson, AW | 1 |
| Bountra, C | 1 |
| Chessell, IP | 1 |
| Day, NC | 1 |
| Schnitzer, TJ | 1 |
| Schug, SA | 1 |
| Larrey, D | 1 |
| Basskin, L | 1 |
| Perrot, S | 1 |
| Rainsford, KD | 2 |
| Whitehouse, MW | 1 |
| Iohom, G | 1 |
| Abdalla, H | 1 |
| O'Brien, J | 1 |
| Szarvas, S | 1 |
| Larney, V | 1 |
| Buckley, E | 1 |
| Butler, M | 1 |
| Shorten, GD | 1 |
| Verhagen, AP | 1 |
| Damen, L | 1 |
| Berger, MY | 1 |
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| Koes, BW | 1 |
| Kemppainen, T | 1 |
| Kokki, H | 1 |
| Tuomilehto, H | 1 |
| Seppä, J | 1 |
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| Gasik, R | 1 |
| Styczyński, T | 1 |
| Ducros, A | 1 |
| Reuben, SS | 1 |
| Buvanendran, A | 1 |
| Dincer, U | 1 |
| Kiralp, MZ | 1 |
| Cakar, E | 1 |
| Yasar, E | 1 |
| Dursan, H | 1 |
| Dubbel, G | 1 |
| Zernikow, B | 1 |
| Hunt, RH | 1 |
| Choquette, D | 1 |
| Craig, BN | 1 |
| De Angelis, C | 1 |
| Habal, F | 1 |
| Fulthorpe, G | 1 |
| Stewart, JI | 1 |
| Turpie, AG | 1 |
| Davis, P | 1 |
| Chou, R | 1 |
| Huffman, LH | 1 |
| Deogaonkar, K | 1 |
| Ghandour, A | 1 |
| Jones, A | 1 |
| Ahuja, S | 1 |
| Lyons, K | 1 |
| Chang, JY | 1 |
| Locke, GR | 1 |
| Schleck, CD | 1 |
| Zinsmeister, AR | 1 |
| Talley, NJ | 2 |
| Landau, CJ | 2 |
| Carr, WD | 1 |
| Razzetti, AJ | 1 |
| Sessler, NE | 1 |
| Munera, C | 1 |
| Ripa, SR | 1 |
| Rossi, S | 1 |
| Assis, DN | 1 |
| Awsare, M | 1 |
| Brunner, M | 1 |
| Skole, K | 1 |
| Rai, J | 1 |
| Andrel, J | 1 |
| Herrine, SK | 1 |
| Reddy, RK | 1 |
| Navarro, VJ | 1 |
| Kean, WF | 1 |
| Kean, IR | 1 |
| Reilingh, ML | 1 |
| Kuijpers, T | 1 |
| Tanja-Harfterkamp, AM | 1 |
| van der Windt, DA | 1 |
| Lacouture, PG | 1 |
| Gaudreault, P | 1 |
| Lovejoy, FH | 1 |
| Stambaugh, JE | 3 |
| Benson, GD | 1 |
| Falliers, CJ | 1 |
| Langley, PG | 1 |
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| Chanchairujira, T | 1 |
| Iñiguez, C | 1 |
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| Braganza, JM | 1 |
| Hanks, GW | 1 |
| Forbes, K | 1 |
| Pal'chun, VT | 1 |
| Kriukov, AI | 1 |
| Ogorodnikov, DS | 1 |
| Uzdennikov, AA | 1 |
| Kunel'skaia, NL | 1 |
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| Szp6e, B | 1 |
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| McFee, R | 1 |
| Caraccio, T | 1 |
| Greensher, J | 1 |
| Jowett, NI | 1 |
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| Travaglini, S | 1 |
| Brini, P | 1 |
| Cavagnino, A | 1 |
| Nikles, CJ | 1 |
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| Clavarino, A | 1 |
| Yelland, MJ | 1 |
| Palangio, M | 1 |
| Damask, MJ | 1 |
| Morris, E | 1 |
| Doyle, RT | 1 |
| Jiang, JG | 1 |
| de Padova, A | 1 |
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| Bailey, B | 1 |
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| Koren, G | 1 |
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| Tornay, AS | 1 |
| Forrest, JA | 4 |
| Adriaenssens, P | 1 |
| Finlayson, ND | 4 |
| Prescott, LF | 4 |
| Adjepon-Yamoah, KK | 3 |
| Johnson, GK | 1 |
| Tolman, KG | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Single Center Study on the Sustained Effect of OnabotulinumtoxinA (BOTOX®) vs. IncobotulinumtoxinA (XEOMIN®) Botulinum Toxin in Adults With Chronic Migraine[NCT05598723] | Phase 3 | 128 participants (Anticipated) | Interventional | 2023-02-24 | Recruiting | ||
| Perioperative Use of Celecoxib to Improve Pain Control in Patients Undergoing Tonsillectomy: a Randomized, Double Blind, Placebo-controlled Trial[NCT00583453] | Phase 2 | 18 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| Effect of a Multimodal Pain Regimen on Pain Control, Patient Satisfaction and Narcotic Use in Orthopaedic Trauma Patients[NCT02160301] | Phase 4 | 0 participants (Actual) | Interventional | 2017-11-30 | Withdrawn (stopped due to Insufficient infrastructure/funding for enrollment) | ||
| The Effect and Contribution of a Perioperative Ketamine Infusion in an Established Enhanced Recovery Pathway[NCT04625283] | Phase 4 | 1,544 participants (Anticipated) | Interventional | 2021-04-12 | Enrolling by invitation | ||
| Survey of Postoperative Pain and Pain Management in Norwegian Hospitals[NCT01413724] | 300 participants (Actual) | Observational | 2010-06-30 | Completed | |||
| Prospective Randomized Controlled Multicentre Trial for Patients With Chronic Low Back Pain Comparing Disci/Rhus Toxicodendron Comp.®, Placebo and Waiting List Group[NCT00567736] | Phase 3 | 150 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461] | 137 participants (Actual) | Observational | 2009-07-31 | Completed | |||
| A Randomized, Double-Blinded, Placebo Controlled Trial Using Single Dose Dexmedetomidine In The Treatment Of Pain In Patients Undergoing Cleft Palate Repair[NCT02915042] | Phase 4 | 0 participants (Actual) | Interventional | 2017-12-31 | Withdrawn (stopped due to Recruitment concerns) | ||
| Genetic, Epigenetic, Psychosocial, and Biological Determinants of Post-surgical Pain After Pectus or Spine Surgery[NCT04031716] | 600 participants (Anticipated) | Interventional | 2018-07-06 | Enrolling by invitation | |||
| Predicting Perioperative Opioid Adverse Effects and Personalizing Analgesia in Children: A Multicenter Pharmacogenetic Study[NCT01495611] | 1,000 participants (Actual) | Observational | 2010-11-30 | Completed | |||
| Randomized Controlled Trial on the Effectiveness of Immediate Versus Delayed Access to Hospital-based Addiction Services[NCT01934751] | 124 participants (Anticipated) | Interventional | 2013-09-30 | Recruiting | |||
| Comparison of the Effectiveness of 2 Manual Therapies on Functional Outcome in Sub-acute and Chronic Non-specific Low Back Pain at 3 Months : a Randomised Controlled Trial[NCT02034864] | 400 participants (Actual) | Interventional | 2014-02-17 | Completed | |||
| Safety and Efficacy of Nonsteroidal Antiinflammatory Drug and Glucocorticoids in Acute Sciatica[NCT01816334] | Phase 4 | 50 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Tolerability, Safety and Activity of IDN5243, 4 mg Bid Intramuscularly in the Treatment of Low Back Pain. A Prospective, Open Label, Single-center, Uncontrolled Study[NCT02568826] | Phase 2 | 0 participants (Actual) | Interventional | 2016-04-30 | Withdrawn (stopped due to No patients enrolled in the study.) | ||
| Burden and Outcome of Shoulder Disorders in Primary Health Care[NCT01300091] | 0 participants (Actual) | Observational | Withdrawn (stopped due to Recruitment not started) | ||||
| Pause and Breathe: Online Self-Help Mindfulness-Based Intervention: Investigation of Its Efficacy and Mechanism of Change[NCT05678972] | 939 participants (Actual) | Interventional | 2023-01-01 | Completed | |||
| Post-Operative Kinesio Taping Impact on Pain in Thoracotomy vs Thoracoscopy[NCT05200689] | 310 participants (Anticipated) | Interventional | 2022-01-09 | Recruiting | |||
| Stentless Florence Robotic Intracorporeal Neobladder (FloRIN)[NCT05891535] | 63 participants (Anticipated) | Interventional | 2021-01-01 | Recruiting | |||
| Efficacy of Intra-Articular Injection of Etanercept for Moderate and Severe Knee Osteoarthritis[NCT02722772] | 60 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | |||
| Efficacy of Subcutaneous Injection of Etanercept for Moderate and Severe Knee Osteoarthritis[NCT02722811] | 60 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | |||
| Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain[NCT02593721] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| A Prospective, Randomized, Double-blind Study Assessing the Efficacy of Intravenous (IV) Ibuprofen Versus IV Acetaminophen for the Treatment of Pain Following Orthopaedic Low Extremity Surgery[NCT03771755] | 62 participants (Actual) | Interventional | 2017-07-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The incidence of post-operative hemorrhage, defined as post-operative bleeding requiring medical intervention or hospitalization during the 10 day post-operative follow-up period. (NCT00583453)
Timeframe: From operative day through 10 days post-operative
| Intervention | Participants (Count of Participants) |
|---|---|
| Celecoxib 200 mg Tablets | 0 |
| Placebo With Same Dosing Schedule as the Active Comparator Arm | 0 |
Participant reported acetaminophen use and its equivalent. Medication use was collected from reported participant journals. (NCT00583453)
Timeframe: From operative day through 10 days post-operative
| Intervention | mg (Mean) | |||
|---|---|---|---|---|
| Day 1 | Average, days 2 to 4 | Average, days 5 to 7 | Average, days 8 to 10 | |
| Celecoxib as Experimerimental Intervention | 2074 | 2245 | 2028 | 1418 |
| Placebo Control, Active Comparator | 3006 | 2934 | 3610 | 2483 |
Activity level, reported by participant utilizing a 10-point ordinal scale (0 = no activity, 10 = return to normal activities). Activity level was measured was collected once daily. (NCT00583453)
Timeframe: From operative day through 10 days post-operative
| Intervention | Activity score (units on a scale) (Mean) | |||
|---|---|---|---|---|
| Day 1 | Average, days 2 to 4 | Average, days 5 to 7 | Average, days 8 to 10 | |
| Celecoxib as Experimerimental Intervention | 2.8 | 3.1 | 5.4 | 7.4 |
| Placebo Control, Active Comparator | 4.5 | 4.1 | 3.7 | 5.7 |
Pain score as reported by participant, measured on a 10 point scale, where 0 = none and 10 = unbearable, collected once daily. (NCT00583453)
Timeframe: day of procedure through post-operative day 10
| Intervention | pain score (units on a scale) (Mean) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Maximum pain, day 1 | maximum pain, averaged across days 2 to 4 | maximum pain, averaged across days 5 to 7 | maximum pain, averaged across days 8 to 10 | Average pain, day 1 | Average pain, averaged across days 2 to 4 | Average pain, averaged across days 5 to 7 | Average pain, averaged across days 8 to 10 | Pain with drinking, day 1 | Pain with drinking, averaged across days 2 to 4 | Pain with drinking, averaged across days 5 to 7 | Pain with drinking, averaged across days 8 to 10 | Activity, day 1 | |
| Celecoxib 200 mg Tablets | 5.0 | 5.1 | 4.4 | 3.6 | 6.1 | 6.2 | 6.1 | 4.9 | 5.7 | 5.4 | 4.9 | 3.9 | 2.8 |
| Placebo With Same Dosing Schedule as the Active Comparator Arm | 6.0 | 6.0 | 5.9 | 4.0 | 7.3 | 7.6 | 7.4 | 5.7 | 6.7 | 6.6 | 5.9 | 4.1 | 4.5 |
Participant reported mophine equivalent use (NCT00583453)
Timeframe: From operative day through 10 days post-operative
| Intervention | mg (Mean) | |||
|---|---|---|---|---|
| Day 1 | Average, days 2 to 4 | Average, days 5 to 7 | Average, days 8 to 10 | |
| Celecoxib as Experimerimental Intervention | 28.9 | 30.4 | 27.8 | 13.2 |
| Placebo Control, Active Comparator | 55.0 | 72.4 | 69.7 | 38.3 |
37 reviews available for acetaminophen and Chronic Illness
| Article | Year |
|---|---|
A Systematic Review of the Evidence Behind Use of Reduced Doses of Acetaminophen in Chronic Liver Disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chronic Disease; Humans; Liver Diseases; Pain | 2018 |
Primary headache disorders.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anticonvulsants; Chronic Disease; Cluster Headache; Cycloox | 2013 |
Can paracetamol (acetaminophen) be administered to patients with liver impairment?
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chronic Disease; Dose-Response Relationship, | 2016 |
Acetaminophen for Chronic Pain: A Systematic Review on Efficacy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chronic Disease; Chronic Pain; Databases, Factual; Humans; | 2016 |
Paracetamol/Tramadol association: the easy solution for mild-moderate pain.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Drug Th | 2008 |
A systematic review of paracetamol for non-specific low back pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chronic Disease; Data Interpretation, Statistical; Humans; | 2008 |
Dysmenorrhoea.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Denervation; Dysme | 2011 |
Management of chronic noncancer pain in depressed patients.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 2011 |
[Post-operative pain management in hospitals].
Topics: Acetaminophen; Analgesia; Analgesia, Epidural; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opi | 2011 |
Juvenile mandibular chronic osteomyelitis: 3 cases and a literature review.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Chronic Disease; Delayed Diagnosis; D | 2013 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Tramadol/paracetamol.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Analgesics; Biological Availability; Chronic Dis | 2003 |
Nonopioid and adjuvant analgesics in chronic pain management: strategies for effective use.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal | 2003 |
[Tolerability of paracetamol].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Bias; Case-Control Studies; Chemical and Drug Induced Liver | 2003 |
[Problem forte--is paracetamol-codeine combination rational?].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Codeine | 2004 |
Valdecoxib for the management of chronic and acute pain.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chr | 2005 |
[Diagnosis and care of repeating headache in children].
Topics: Acetaminophen; Age Factors; Child; Child, Preschool; Chronic Disease; Female; Finland; Headache; Hum | 2005 |
Update on guidelines for the treatment of chronic musculoskeletal pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2006 |
Combination analgesia in 2005 - a rational approach: focus on paracetamol-tramadol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2006 |
[Is there a risk to prescribe paracetamol at therapeutic doses in patients with acute or chronic liver disease?].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chro | 2006 |
[Management strategies for the treatment of non malignant chronic pain in the elderly].
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Humans; Musculos | 2006 |
Is any one analgesic superior for episodic tension-type headache?
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Diclofenac; Dos | 2006 |
[Specific of pharmacotherapy management in back pain among the elderly].
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Back Pain; Chronic Disease; | 2006 |
[Acute and chronic headaches].
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir | 2006 |
Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Anesthetics, Local; Anima | 2007 |
Approach to managing musculoskeletal pain: acetaminophen, cyclooxygenase-2 inhibitors, or traditional NSAIDs?
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cyclooxygenase 2 Inhi | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Chronic recurrent multifocal osteomyelitis presenting as acute scoliosis: a case report and review of literature.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Biopsy; Child; Chronic Disease; F | 2008 |
Management of chronic musculoskeletal pain in the elderly: opinions on oral medication use.
Topics: Acetaminophen; Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antipain; Chroni | 2008 |
Chronic pain of childhood: a pharmacologic approach.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics; Analgesics, Opioid; Anti-Anxiety Agents; Anticon | 1984 |
Hepatotoxicity following the therapeutic use of antipyretic analgesics.
Topics: Acetaminophen; Alcohol Drinking; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug | 1983 |
Analgesic-antipyretic choices for children with asthma: a review of safety and risk of common preparations.
Topics: Acetaminophen; Adolescent; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Br | 1984 |
The management of chronic pain in patients with breast cancer. The Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer. Canadian Society of Palliative Care Physicians. Canadian Association of Radiation Oncologist
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, L | 1998 |
Chronic pain in the older patient: management strategies. 2.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antide | 2002 |
[The latest in headache treatment].
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Analgesics, Non-Narcotic; Angiotensin-Converting | 2002 |
Drug metabolism in liver disease.
Topics: Acetaminophen; Acute Disease; Antipyrine; Chemical and Drug Induced Liver Injury; Chronic Disease; H | 1975 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Bile; Bile Acids and Salts; Biotransformation; Cell Survival; Chemical and Drug Induc | 1986 |
38 trials available for acetaminophen and Chronic Illness
| Article | Year |
|---|---|
Pharmacokinetics/pharmacodynamics of acetaminophen analgesia in Japanese patients with chronic pain.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Asian People; Biotransformation; Chronic Disea | 2007 |
Celecoxib Versus Placebo in Tonsillectomy: A Prospective, Randomized, Double-Blind Placebo-Controlled Trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Celecoxib; Chronic Disease; Cycl | 2016 |
Efficacy and safety of low-dose transdermal buprenorphine patches (5, 10, and 20 microg/h) versus prolonged-release tramadol tablets (75, 100, 150, and 200 mg) in patients with chronic osteoarthritis pain: a 12-week, randomized, open-label, controlled, pa
Topics: Acetaminophen; Administration, Cutaneous; Administration, Oral; Adult; Aged; Aged, 80 and over; Anal | 2009 |
Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2009 |
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana | 2009 |
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana | 2009 |
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana | 2009 |
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana | 2009 |
Role of dexamethasone in reducing pain after endoscopic sinus surgery in adults: a double-blind prospective randomized trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Chronic Disease; Dexametha | 2010 |
Acute pain after total hip arthroplasty does not predict the development of chronic postsurgical pain 6 months later.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Arthroplasty, Replacement, Hip; Celecoxib; Ch | 2010 |
Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chronic Diseas | 2010 |
A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chronic Disease; Dose-Respo | 2011 |
Efficacy of injections with Disci/Rhus toxicodendron compositum for chronic low back pain--a randomized placebo-controlled trial.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chron | 2011 |
Tramadol/acetaminophen combination tablets for the treatment of chronic lower back pain: a multicenter, randomized, double-blind, placebo-controlled outpatient study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Dose-Resp | 2003 |
Analgesic efficacy and safety of tramadol/ acetaminophen combination tablets (Ultracet) in treatment of chronic low back pain: a multicenter, outpatient, randomized, double blind, placebo controlled trial.
Topics: Acetaminophen; Adult; Aged; Ambulatory Care; Analgesics, Non-Narcotic; Chronic Disease; Dose-Respons | 2004 |
Acupuncture versus placebo for the treatment of chronic mechanical neck pain: a randomized, controlled trial.
Topics: Acetaminophen; Acupuncture Therapy; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chroni | 2004 |
Inter- and intraindividual variabilities in pharmacokinetics of fentanyl after repeated 72-hour transdermal applications in cancer pain patients.
Topics: Acetaminophen; Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; | 2005 |
The associations between severity of early postoperative pain, chronic postsurgical pain and plasma concentration of stable nitric oxide products after breast surgery.
Topics: Acetaminophen; Adult; Aged; Analgesia; Anxiety; Breast Neoplasms; Bupivacaine; Celecoxib; Chronic Di | 2006 |
Acetaminophen is highly effective in pain treatment after endoscopic sinus surgery.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chronic Disease; Double-Blind Method; Endoscopy; Fem | 2006 |
Caudal epidural injection versus non-steroidal anti-inflammatory drugs in the treatment of low back pain accompanied with radicular pain.
Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid | 2007 |
Etoricoxib challenge in patients with chronic urticaria with NSAID intolerance.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cyclooxygenase | 2007 |
Buprenorphine transdermal delivery system in adults with persistent noncancer-related pain syndromes who require opioid therapy: a multicenter, 5-week run-in and randomized, double-blind maintenance-of-analgesia study.
Topics: Acetaminophen; Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, No | 2007 |
A double-blind comparison of meptazinol versus distalgesic in acute of chronic pain presenting to the general practitioner.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Azepines; Chronic Disease; Dextropropoxyphene | 1982 |
A double-blind comparison of meptazinol versus paracetamol and placebo in acute and chronic painful conditions presented to the general practitioner.
Topics: Acetaminophen; Acute Disease; Adult; Azepines; Chronic Disease; Double-Blind Method; Female; Humans; | 1982 |
Histological study of the effects of three anti-inflammatory preparations on the gastric mucosa.
Topics: Acetaminophen; Acute Disease; Adult; Anti-Inflammatory Agents; Chronic Disease; Dextropropoxyphene; | 1981 |
Efficacy of controlled-release codeine in chronic non-malignant pain: a randomized, placebo-controlled clinical trial.
Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Analysis of Variance; Chronic Disease; Codeine; Cros | 1995 |
Assay of paracetamol and its metabolites in urine, plasma and saliva of children with chronic liver disease.
Topics: Acetaminophen; Adult; Child; Child, Preschool; Chromatography, High Pressure Liquid; Chronic Disease | 1995 |
Metabolism of paracetamol in children with chronic liver disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biotransformation; Child; Child, Preschool; Chromatography, | 1996 |
The effect of hypoxaemia on drug disposition in chronic respiratory failure.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Biological Availability; Chronic Disease; Cros | 1996 |
Gastric emptying following pylorus-preserving Whipple and duodenum-preserving pancreatic head resection in patients with chronic pancreatitis.
Topics: Acetaminophen; Adult; Cholecystokinin; Chronic Disease; Female; Gastric Emptying; Gastrins; Humans; | 1997 |
Allogeneic peripheral blood stem cell transplantation in acute non-lymphoblastic leukemia.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Blood Transfusion; Chroni | 1998 |
Preliminary experiences with a single-patient trials service in general practice.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N | 2000 |
Combination hydrocodone and ibuprofen versus combination codeine and acetaminophen for the treatment of chronic pain.
Topics: Acetaminophen; Adult; Aged; Analgesics; Chronic Disease; Codeine; Double-Blind Method; Drug Therapy, | 2000 |
Randomized placebo controlled trial of lofexidine hydrochloride for chronic pelvic pain in women.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Anti-Inflammatory Agents, Non-Steroidal; Body Mass Index; | 2001 |
The efficacy and tolerability of controlled-release dihydrocodeine tablets and combination dextropropoxyphene/paracetamol tablets in patients with severe osteoarthritis of the hips.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Chronic Disease; Codeine; Delayed-Action Preparations | 1992 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Chronic urticaria exacerbated by the antioxidant food preservatives, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT).
Topics: Acetaminophen; Adult; Antioxidants; Aspirin; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Chr | 1990 |
Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study.
Topics: Acetaminophen; Aged; Chronic Disease; Codeine; Double-Blind Method; Drug Combinations; Hip Joint; Hu | 1990 |
The combination of ibuprofen and oxycodone/acetaminophen in the management of chronic cancer pain.
Topics: Acetaminophen; Adult; Aged; Analysis of Variance; Bone Neoplasms; Chronic Disease; Codeine; Double-B | 1988 |
Analgesic use and chronic renal disease.
Topics: Acetaminophen; Adult; Aged; Analgesics; Arthritis; Aspirin; Chronic Disease; Dose-Response Relations | 1989 |
Symptomatic treatment of chronically recurring tension headache: a placebo-controlled, multicenter investigation of Fioricet and acetaminophen with codeine.
Topics: Acetaminophen; Adult; Barbiturates; Caffeine; Chronic Disease; Clinical Trials as Topic; Consumer Be | 1987 |
96 other studies available for acetaminophen and Chronic Illness
| Article | Year |
|---|---|
Effect of Over the Counter Ibuprofen Dosing after Sinus Surgery for Chronic Rhinosinusitis: A Prospective Cohort Pilot Study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Cohort St | 2020 |
Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA.
Topics: Acetaminophen; Animals; Cell Proliferation; Chronic Disease; Disease Models, Animal; Epidermal Growt | 2021 |
Understanding the migraine treatment landscape prior to the introduction of calcitonin gene-related peptide inhibitors: Results from the Assessment of TolerabiliTy and Effectiveness in MigrAINe Patients using Preventive Treatment (ATTAIN) study.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agent | 2021 |
Prevalence and clinical characteristics of headaches among undergraduate students in three tertiary institutions in Ilorin, Nigeria.
Topics: Acetaminophen; Adolescent; Adult; Chronic Disease; Cross-Sectional Studies; Female; Headache; Humans | 2017 |
[In process].
Topics: Acetaminophen; Adult Day Care Centers; Aged; Aged, 80 and over; Ascorbic Acid; Caregivers; Chronic D | 2017 |
Novel Factors Associated With Analgesic and Anti-inflammatory Medication Use in Distance Runners: Pre-race Screening Among 76 654 Race Entrants-SAFER Study VI.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Athletic Injuries; Chroni | 2018 |
Late oral acetaminophen versus immediate surgical ligation in preterm infants with persistent large patent ductus arteriosus.
Topics: Acetaminophen; Administration, Oral; Cardiac Surgical Procedures; Chronic Disease; Clinical Decision | 2018 |
Access to means of lethal overdose among psychiatric patients with co-morbid physical health problems: Analysis of national suicide case series data from the United Kingdom.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Chronic Disease; Comorbidity; Drug Overdose; England; Fema | 2019 |
TAFI deficiency promotes liver damage in murine models of liver failure through defective down-regulation of hepatic inflammation.
Topics: Acetaminophen; Actins; Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Ca | 2013 |
Multiple nonsteroidal anti-inflammatory drug-induced cutaneous disease: what differentiates patients with and without underlying chronic spontaneous urticaria?
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroida | 2014 |
Acute and chronic effects of IL-22 on acetaminophen-induced liver injury.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Inj | 2014 |
Validation of potential candidate biomarkers of drug-induced nephrotoxicity and allodynia in medication-overuse headache.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Chronic Disea | 2015 |
Chronic pain among community-dwelling elderly: a population-based clinical study.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2016 |
Hepatotoxicity induced by acute and chronic paracetamol overdose in children: Where do we stand?
Topics: Acetaminophen; Acute Disease; Adolescent; Age Distribution; Analgesics, Non-Narcotic; Chemical and D | 2017 |
Challenges of fragmented care in long-term management of pelvic pain.
Topics: Acetaminophen; Adult; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Anxiety Agents; Chr | 2007 |
Fibromyalgia: poorly understood; treatments are disappointing.
Topics: Acetaminophen; Acupuncture Therapy; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Ant | 2009 |
Chronic pain-related changes in endogenous opioid analgesia: a case report.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Back Pain; Chronic Disease; Female; Fol | 2010 |
Cortical hyperexcitability and mechanism of medication-overuse headache.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Chronic Disease; Cortical Spreading | 2010 |
Case scenario: self-extraction of intrathecal pump medication with a concomitant intrathecal granulomatous mass.
Topics: Acetaminophen; Administration, Cutaneous; Adult; Analgesics; Analgesics, Non-Narcotic; Analgesics, O | 2011 |
Adherence and long-term effect of oxycodone/paracetamol in chronic noncancer pain: a retrospective study.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; M | 2011 |
Stellate ganglion blockade (SGB) for refractory index finger pain - a case report.
Topics: Abdominal Pain; Accidental Falls; Acetaminophen; Adult; Amines; Autonomic Nerve Block; Chronic Disea | 2011 |
Chronic genital ulceration: a 'topical' issue.
Topics: Acetaminophen; Administration, Topical; Adult; Analgesics, Non-Narcotic; Chronic Disease; Humans; Ma | 2011 |
Co-morbidities and Alzheimer's disease: the need for vigilance.
Topics: Acetaminophen; Alzheimer Disease; Analgesics, Non-Narcotic; Brain Diseases; Chronic Disease; Comorbi | 2011 |
Unintentional chronic acetaminophen poisoning during pregnancy resulting in liver transplantation.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Liver Failure, Acut | 2012 |
Chronic acetaminophen ingestion resulting in severe anion gap metabolic acidosis secondary to 5-oxoproline accumulation: an under diagnosed phenomenon.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis, Lactic; Analgesics, Non-Narcotic; Chronic Disease; D | 2012 |
Migraine and proctitis: what is the link?
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Caffeine; Central Nervous System | 2013 |
Overuse of paracetamol caffeine aspirin powders affects cerebral glucose metabolism in chronic migraine patients.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Br | 2013 |
Comment: hepatotoxicity associated with chronic acetaminophen administration in patients without risk factors.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chronic | 2002 |
Chronic liver disease in murine hereditary tyrosinemia type 1 induces resistance to cell death.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Cell Survival; Central Nervous System D | 2004 |
Expression of cancer testis antigens in pancreatic carcinoma cell lines, pancreatic adenocarcinoma and chronic pancreatitis.
Topics: Acetaminophen; Adenocarcinoma; Antigens, Neoplasm; Chronic Disease; DNA-Binding Proteins; Female; Ge | 2004 |
Information from your family doctor. Chronic pain medicines.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Dise | 2004 |
The complexity of managing pain for frail elders.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Dise | 2004 |
Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Attention; Behavior, Animal; | 2004 |
Prospective evaluation of repeated supratherapeutic acetaminophen (paracetamol) ingestion.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Algorithms; Analges | 2004 |
Not enough relief from too much acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and Drug Induced Live | 2004 |
Characterizations of long-term oxycodone/acetaminophen prescriptions in veteran patients.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Drug Combinatio | 2004 |
Chronic back pain: searching for causes and cures.
Topics: Acetaminophen; Chronic Disease; Drug Therapy, Combination; Humans; Low Back Pain; Pain Measurement; | 2004 |
Summaries for patients. Acupuncture for treatment of chronic neck pain.
Topics: Acetaminophen; Acupuncture Therapy; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chroni | 2004 |
Fulminant hepatic failure due to chronic acetaminophen intoxication in an infant.
Topics: Acetaminophen; Acetylcysteine; Chronic Disease; Emergency Medicine; Female; Humans; Infant; Liver Fa | 2005 |
Short-term paracetamol therapy during pregnancy and a lower rate of preterm birth.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anti-Infective Agents; Chronic | 2005 |
Churg-Strauss syndrome associated with hypersensitivity to acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Arteries; Biopsy; Chronic Disease; Churg-Strauss Syndrome; | 2005 |
Circadian pattern of spontaneous behavior in monarthritic rats: a novel global approach to evaluation of chronic pain and treatment effectiveness.
Topics: Acetaminophen; Activity Cycles; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthri | 2005 |
Patient's page. Bone health facts.
Topics: Acetaminophen; Adult; Child; Child Abuse; Chronic Disease; Female; Humans; Male; Pain; Pain Manageme | 2005 |
Use of acetaminophen in young subelite athletes.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Bicycling; Case-Control S | 2005 |
The pharmacokinetics of a single rectal dose of paracetamol (40 mg x kg(-1)) in children with liver disease.
Topics: Acetaminophen; Administration, Rectal; Adolescent; Analgesics, Non-Narcotic; Anesthesia, General; Bi | 2006 |
Changes in dorsal root ganglion CGRP expression in a chronic inflammatory model of the rat knee joint: differential modulation by rofecoxib and paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Calcitonin Gene-Related P | 2007 |
Comparison of a scheduled narcotic for chronic pain with a similar medication for breakthrough pain only is not a clinically relevant comparison.
Topics: Acetaminophen; Chronic Disease; Cost-Benefit Analysis; Delayed-Action Preparations; Drug Therapy, Co | 2006 |
Paracetamol [acetaminophen]-induced gastrotoxicity: revealed by induced hyperacidity in combination with acute or chronic inflammation.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Animals; Arthritis, Ex | 2006 |
[Ambulatory pain management for children in the family practice].
Topics: Acetaminophen; Acute Disease; Ambulatory Care; Analgesics; Analgesics, Opioid; Child; Chronic Diseas | 2007 |
Risk factors for chronic constipation and a possible role of analgesics.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; | 2007 |
Use of over-the-counter analgesics in patients with chronic liver disease: physicians' recommendations.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2008 |
Course and prognosis of shoulder symptoms in general practice.
Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid | 2008 |
The management of the patient with chronic pain due to advanced malignancy.
Topics: Acetaminophen; Analgesics; Aspirin; Chronic Disease; Drug Therapy, Combination; Humans; Narcotics; N | 1982 |
Platelet adhesiveness to glass beads in liver disease.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chronic Disease; Glass; Hemoperfusion; Hepati | 1982 |
Pharmacological treatment of cancer pain with special reference to the oral use of morphine.
Topics: Acetaminophen; Administration, Oral; Aspirin; Biological Availability; Chronic Disease; Codeine; Hum | 1982 |
Newer concepts in pain therapy by applied pharmacology of the analgesics.
Topics: Acetaminophen; Analgesics; Aspirin; Chronic Disease; Humans; Hydroxyzine; Morphine; Morphine Derivat | 1981 |
Non-steroidal anti-inflammatory drugs in elderly people. Treat mild chronic pain with paracetamol initially.
Topics: Acetaminophen; Aged; Chronic Disease; Humans; Pain | 1995 |
Paracetamol and children.
Topics: Acetaminophen; Child, Preschool; Chronic Disease; Humans; Infant; Poisoning | 1994 |
Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency.
Topics: Acetaminophen; Aged; Alcoholism; Chronic Disease; Glutathione; Heart Failure; Humans; Kidney; Liver; | 1994 |
Chronic paracetamol poisoning in children: a warning to health professionals.
Topics: Acetaminophen; Blood Coagulation Disorders; Chronic Disease; Diarrhea; Drug Overdose; Health Occupat | 1994 |
Factors responsible for continuing morbidity after paracetamol poisoning in Chinese patients in Hong Kong.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Asian People; C | 1996 |
Increased resistance to acetaminophen-induced hepatotoxicity in retrovirus-infected mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical and Drug Induced Liver | 1996 |
Paracetamol-induced cholestatic and granulomatous liver injuries.
Topics: Acetaminophen; Acute Disease; Adult; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcot | 1997 |
Risk factors between analgesic use and chronic nephropathy in Thailand.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ca | 1996 |
[Clinical features of daily chronic headache].
Topics: Acetaminophen; Adult; Age of Onset; Analgesics; Benzodiazepines; Caffeine; Chronic Disease; Ergotami | 1997 |
Adding methionine to way paracetamol tablet. Methionine is important in treatment of chronic pancreatitis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chronic Disease; Drug Combinations; Humans; Methio | 1998 |
Co-proxamol is effective in chronic pain.
Topics: Acetaminophen; Chronic Disease; Dextropropoxyphene; Drug Combinations; Humans; Pain; Treatment Outco | 1998 |
[On postop strategies in surgically treated forms of ethmoid sinusitis].
Topics: Acetaminophen; Adult; Aged; Analgesics; Analgesics, Non-Narcotic; Caffeine; Chronic Disease; Codeine | 1998 |
[Paracetamol-induced tubulointerstitial nephritis in a chronic alcoholic patient].
Topics: Acetaminophen; Acute Disease; Adult; Alcoholism; Biopsy; Chemical and Drug Induced Liver Injury; Chr | 1998 |
Combined antipyretic therapy: another potential source of chronic acetaminophen toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Chronic Disease; Drug Interactions; Drug Therapy, Co | 1998 |
AGS clinical practice guidelines: the management of chronic pain in older persons.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Age | 1998 |
Analgesics in the management of chronic pain. Part two: Step I analgesic drug therapy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; H | 1998 |
Limitation of over the counter sales of paracetamol. Restriction of 16g will not prevent overdose and is unhelpful for patients with chronic disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chronic Disease; Drug Overdose; Humans; Nonprescription Dru | 1998 |
"The silent killer": chronic acetaminophen toxicity in a toddler.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chronic Disease; Fatal Outcome; Humans; Infant; Infant, New | 1999 |
[Chronic pain during dialysis. Pharmacologic therapy and its costs].
Topics: Acetaminophen; Analgesics; Arthralgia; Buprenorphine; Chronic Disease; Codeine; Disability Evaluatio | 1999 |
Economic evaluation alongside n-of-1 trials: getting closer to the margin.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; C | 2001 |
Drug-seeking behavior--a differential approach.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chronic Disease; Humans; Pain; Pain Management | 2001 |
Is chronic poisoning with acetaminophen in children a frequent occurrence in Toronto?
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Child, Preschool; Chronic Disea | 2001 |
Chronic pain, bereavement and overdose in a depressed elderly woman.
Topics: Acetaminophen; Aged; Aged, 80 and over; Aging; Aortic Aneurysm, Thoracic; Aspirin; Back Pain; Bereav | 2002 |
Distribution of benorylate in plasma, synovial fluid and tissue in rheumatoid arthritis.
Topics: Acetaminophen; Arthritis, Rheumatoid; Chronic Disease; Humans; Salicylates; Synovectomy; Synovial Fl | 1975 |
A comprehensive treatment approach to chronic low back pain.
Topics: Acetaminophen; Analgesics, Opioid; Back Pain; Chronic Disease; Comprehensive Health Care; Hospitaliz | 1976 |
Serum alpha-fetoprotein levels in patients with acute and chronic liver disease. Relation to hepatocellular regeneration and development of primary liver cell carcinoma.
Topics: Acetaminophen; Acute Disease; Adult; alpha-Fetoproteins; Carcinoma, Hepatocellular; Chronic Disease; | 1977 |
Chronic hepatic inflammation and fibrosis due to low doses of paracetamol.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chronic Disease; Hip Joint; Humans; Joint Dis | 1978 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Animals; Chemical and Drug Induced Liver Injury; Chronic Disease; Contraceptiv | 1979 |
Paracetamol metabolism in chronic liver disease.
Topics: Acetaminophen; Adult; Aged; Chronic Disease; Female; Half-Life; Humans; Liver Diseases; Male; Middle | 1979 |
Antipyrine, paracetamol, and lignocaine elimination in chronic liver disease.
Topics: Acetaminophen; Adult; Aged; Antipyrine; Chronic Disease; Female; Half-Life; Humans; Kinetics; Lidoca | 1977 |
Chronic liver disease and acetaminophen.
Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; Gluta | 1977 |
Proceedings: Antipyrine, lingocaine and paracetamol metabolism in chronic liver disease.
Topics: Acetaminophen; Adult; Aged; Antipyrine; Chronic Disease; Female; Humans; Lidocaine; Liver Diseases; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Nonnarcotic analgesics and tricyclic antidepressants for the treatment of chronic nonmalignant pain.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic | 1991 |
Effect of acute and chronic propranolol administration on antipyrine and paracetamol clearance in patients with chronic liver disease.
Topics: Acetaminophen; Adult; Aged; Antipyrine; Chronic Disease; Drug Administration Schedule; Female; Human | 1989 |
Analgesic use and chronic renal disease.
Topics: Acetaminophen; Analgesics; Aspirin; Chronic Disease; Data Collection; Humans; Kidney Diseases; Phena | 1989 |
Chronic fixed drug eruption caused by acetaminophen.
Topics: Acetaminophen; Arm; Chronic Disease; Drug Eruptions; Female; Hand Dermatoses; Humans; Middle Aged | 1988 |
Environmental factors and chronic unexplained dyspepsia. Association with acetaminophen but not other analgesics, alcohol, coffee, tea, or smoking.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Coffee | 1988 |
Environmental factors in aetiology of chronic gastric ulcer: a case control study of exposure variables before the first symptoms.
Topics: Acetaminophen; Alcohol Drinking; Analgesics; Anti-Inflammatory Agents; Aspirin; Chronic Disease; Fem | 1985 |
Community survey of analgesic consumption and kidney function in women.
Topics: Acetaminophen; Adult; Age Factors; Analgesics; Blood Pressure; Chronic Disease; Creatinine; Female; | 1973 |