acetaminophen has been researched along with Cholestasis, Intrahepatic in 7 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Cholestasis, Intrahepatic: Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Necrosis is typically the consequence of acute metabolic perturbation with ATP depletion as occurs in ischemia/reperfusion and acute drug-induced hepatotoxicity." | 2.43 | Apoptosis and necrosis in the liver: a tale of two deaths? ( Gores, GJ; Lemasters, JJ; Malhi, H, 2006) |
| " The possible causes for the injury from ostensibly nontoxic drug levels appear to be either the induction by chronic alcohol intake of the cytochrome P-450 system responsible for converting acetaminophen to a toxic metabolite, or the effect of alcoholism and the associated malnutrition in reducing the glutathione concentration, responsible normally for preventing hepatotoxicity by conjugation with the toxic metabolite." | 2.37 | Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure. ( Adler, E; Benjamin, SB; Cuccherini, BA; Seeff, LB; Zimmerman, HJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sahagún Flores, JE | 1 |
| Soto Ortiz, JA | 1 |
| Tovar Méndez, CE | 1 |
| Cárdenas Ochoa, EC | 1 |
| Hernández Flores, G | 1 |
| Pagano, MB | 1 |
| Hobbs, W | 1 |
| Linenberger, M | 1 |
| Delaney, M | 1 |
| Malhi, H | 1 |
| Gores, GJ | 1 |
| Lemasters, JJ | 1 |
| Ruiz, ML | 1 |
| Villanueva, SS | 1 |
| Luquita, MG | 1 |
| Ikushiro, S | 1 |
| Mottino, AD | 1 |
| Catania, VA | 1 |
| Heathcote, J | 1 |
| Wanless, IR | 1 |
| Shinzawa, H | 1 |
| Togashi, H | 1 |
| Sugahara, K | 1 |
| Ishibashi, M | 1 |
| Terui, Y | 1 |
| Aoki, M | 1 |
| Mitsuhashi, H | 1 |
| Matsuo, T | 1 |
| Watanabe, H | 1 |
| Abe, T | 1 |
| Ohno, S | 1 |
| Saito, K | 1 |
| Saito, T | 1 |
| Yamada, N | 1 |
| Takahashi, T | 1 |
| Horiuchi, R | 1 |
| Seeff, LB | 1 |
| Cuccherini, BA | 1 |
| Zimmerman, HJ | 1 |
| Adler, E | 1 |
| Benjamin, SB | 1 |
3 reviews available for acetaminophen and Cholestasis, Intrahepatic
| Article | Year |
|---|---|
Apoptosis and necrosis in the liver: a tale of two deaths?
Topics: Acetaminophen; Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cholestasis, Intrahepati | 2006 |
Hepatotoxicity: newer aspects of pathogenesis and treatment.
Topics: Acetaminophen; Acetylcysteine; Adenoma, Liver Cell; Adult; Amoxicillin; Anabolic Agents; Beverages; | 1995 |
Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure.
Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Blood Coagulati | 1986 |
4 other studies available for acetaminophen and Cholestasis, Intrahepatic
| Article | Year |
|---|---|
[Stevens-Johnson syndrome plus intrahepatic cholestasis caused by clindamycin or chlorpheniramine].
Topics: Acetaminophen; Betamethasone; Bronchitis; Chlorpheniramine; Cholestasis, Intrahepatic; Clindamycin; | 2009 |
Plasma and red cell exchange transfusions for erythropoietic protoporphyria: a case report and review of the literature.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Arthroplasty, Replacement, Knee; Cholestasis, Intrahepatic; | 2012 |
Beneficial effect of spironolactone administration on ethynylestradiol-induced cholestasis in the rat: involvement of up-regulation of multidrug resistance-associated protein 2.
Topics: Acetaminophen; Animals; Anion Transport Proteins; Antiporters; ATP Binding Cassette Transporter, Sub | 2007 |
Acute cholestatic hepatitis caused by a probable allergic reaction to paracetamol in an adolescent.
Topics: Acetaminophen; Acute Disease; Adolescent; Analgesics, Non-Narcotic; Bilirubin; Chemical and Drug Ind | 2001 |