acetaminophen has been researched along with Chemical and Drug Induced Liver Injury, Chronic in 119 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical and Drug Induced Liver Injury, Chronic: Liver disease lasting six months or more, caused by an adverse effect of a drug or chemical. The adverse effect may be caused by drugs, drug metabolites, chemicals from the environment, or an idiosyncratic response.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Abietic acid has been known to exhibit anti-inflammatory activity." | 5.91 | Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis. ( An, Y; Guan, L; Han, D; Luo, Q, 2023) |
| "Coenzyme Q10 (CoQ10) which acts as an electron transporter in the mitochondrial respiratory chain has many beneficial effects on liver diseases." | 5.62 | CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury. ( Chen, S; Chen, X; Fang, W; He, T; Tang, Y; Zhang, P, 2021) |
| "Acetaminophen (APAP) is a commonly used and effective analgesic/antipyretic agent and relatively safe drug even in long-term treatment." | 2.52 | [Investigation of Predisposition Biomarkers to Identify Risk Factors for Drug-induced Liver Injury in Humans: Analyses of Endogenous Metabolites in an Animal Model Mimicking Human Responders to APAP-induced Hepatotoxicity]. ( Kobayashi, A; Kondo, K; Sugai, S, 2015) |
| "Acetaminophen (APAP) is a widely used antipyretic and analgesic." | 1.91 | Anti-TLR4 IgG2 Prevents Acetaminophen-induced Acute Liver Injury through the Toll-like Receptor 4/MAPKs Signaling Pathway in Mice. ( Feng, T; Gong, D; Wang, C; Wang, M; Wang, Y; Yao, C; Zhang, Y; Zhu, J, 2023) |
| "Acetaminophen (APAP) is a widely used analgesic drug, but its over-dose is associated with acute liver failure where the clinical approved antidote treatment is limited." | 1.91 | Pien Tze Huang attenuated acetaminophen-induced liver injury by autophagy mediated-NLRP3 inflammasome inhibition. ( Chang, D; He, Y; Huang, M; Li, S; Lin, Y; Liu, W; Xu, W; Zhang, Q; Zhao, R; Zheng, Y; Zhou, X, 2023) |
| "Abietic acid has been known to exhibit anti-inflammatory activity." | 1.91 | Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis. ( An, Y; Guan, L; Han, D; Luo, Q, 2023) |
| "Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease and its influence on drug-induced liver injury (DILI) is not fully understood." | 1.91 | Absence of Increased Susceptibility to Acetaminophen-Induced Liver Injury in a Diet-Induced NAFLD Mouse Model. ( Clayton, NP; Cortes, RA; Izawa, T; Pandiri, AR; Sills, RC; Travlos, GS, 2023) |
| "Acetaminophen (APAP) is an over-the-counter antipyretic analgesic that exhibits high hepatotoxicity when used for long-term or in overdoses." | 1.91 | Protection of taraxasterol against acetaminophen-induced liver injury elucidated through network pharmacology and in vitro and in vivo experiments. ( Ge, B; Kong, L; Liu, X; Sang, R; Wang, W; Yan, K; Yu, M; Yu, Y; Zhang, X, 2023) |
| "Curcumin is a naturally occurring compound that has antioxidant properties, acts as a hepatoprotective, and lowers lipid peroxidation." | 1.91 | The Effect of Curcumin Nanoparticles on Paracetamol-induced Liver Injury in Male Wistar Rats. ( Damayanti, IP; Mahati, E; Nugroho, T; Suhartono, S; Suryono, S; Susanto, H; Susilaningsih, N; Suwondo, A, 2023) |
| " Animals were sacrificed at 5, 10 and 24 hours post-APAP dosing (hpd)." | 1.72 | Prophylactic effect of edible bird's nest on acetaminophen-induced liver injury response in mice model. ( Ain-Fatin, R; Muhammad-Azam, F; Noordin, MM; Nur-Fazila, SH; Yasmin, AR; Yimer, N, 2022) |
| "Gastrodin is a major active phenolic glycoside extract from Gastrodia elata, an important herb used in traditional medicine." | 1.72 | Gastrodin Alleviates Acetaminophen-Induced Liver Injury in a Mouse Model Through Inhibiting MAPK and Enhancing Nrf2 Pathways. ( Chou, AH; Hu, LM; Lee, HC; Liao, CC; Liu, FC; Yu, HP, 2022) |
| " However, long-term use of SJW has raised safety concerns in clinical practice because of drug-drug interactions." | 1.72 | St. John's Wort Exacerbates Acetaminophen-Induced Liver Injury by Activation of PXR and CYP-Mediated Bioactivation. ( Bi, H; Fan, S; Gao, Y; Huang, M; Jiang, Y; Li, Y; Song, S; Zhou, Y, 2022) |
| "Acetaminophen (APAP) is a frequently used painkiller, and hepatotoxic side effects limit its use." | 1.72 | Exploration of the Protective Mechanism of Naringin in the Acetaminophen-Induced Hepatic Injury by Metabolomics. ( Cai, Y; Chen, B; Gu, W; Li, M; Lin, Z; Liu, W; Shen, Z; Wan, CC; Wang, G; Yan, T; Zhao, S; Zheng, G, 2022) |
| "Naringin (Nar) has been reported to exert potential hepatoprotective effects against acetaminophen (APAP)-induced injury." | 1.72 | Naringin regulates mitochondrial dynamics to protect against acetaminophen-induced hepatotoxicity by activating the AMPK/Nrf2 signaling pathway in vitro. ( Bi, Y; Chen, Y; Duan, Z; Guo, W; Li, Z; Wu, Q; Yu, P, 2022) |
| "Coenzyme Q10 (CoQ10) which acts as an electron transporter in the mitochondrial respiratory chain has many beneficial effects on liver diseases." | 1.62 | CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury. ( Chen, S; Chen, X; Fang, W; He, T; Tang, Y; Zhang, P, 2021) |
| "Acetaminophen treatment obviously increased the levels of ALT and AST, changed hepatic histopathology, promoted oxidative stress, decreased antioxidant enzyme activities, and elevated the pro-inflammatory cytokines." | 1.62 | Echinacoside alleviates acetaminophen-induced liver injury by attenuating oxidative stress and inflammatory cytokines in mice. ( Chen, C; Li, B; Thida, M; Zhang, X, 2021) |
| "Carbon monoxide (CO) is an important gaseous molecule with versatile functions including anti-oxidation and anti-inflammation, and we previous reported the therapeutic potential of a nano-designed CO donor SMA/CORM2 in a dextran sulphate sodium (DSS) induced mouse colitis model." | 1.62 | Nano-designed carbon monoxide donor SMA/CORM2 exhibits protective effect against acetaminophen induced liver injury through macrophage reprograming and promoting liver regeneration. ( Fang, J; Guo, C; Hu, W; Jiang, W; Lv, J; Qin, M; Song, B; Xia, Z; Xu, D; Zhang, C; Zhang, S, 2021) |
| "Baicalin has already been reported to alleviate acetaminophen (APAP)-induced acute liver injury in our previous study." | 1.56 | Baicalin promotes liver regeneration after acetaminophen-induced liver injury by inducing NLRP3 inflammasome activation. ( Bai, Q; Hu, F; Huang, Z; Ji, L; Lu, B; Shi, L; Wei, M; Zhang, S; Zhang, T, 2020) |
| " Fits of synthetic data derived from chronic use overdose scenarios to MALD lead to accurate predictions of outcome, even when liver injury is the result of sustained overuse." | 1.40 | Mathematical modelling of chronic acetaminophen metabolism and liver injury. ( Adler, FR; Remien, CH; Sussman, NL, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.68) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (3.36) | 29.6817 |
| 2010's | 11 (9.24) | 24.3611 |
| 2020's | 102 (85.71) | 2.80 |
| Authors | Studies |
|---|---|
| Yan, M | 1 |
| Zhao, C | 1 |
| Lu, S | 1 |
| Cui, J | 1 |
| Sun, Z | 1 |
| Liu, X | 4 |
| Liu, S | 1 |
| Huo, Y | 1 |
| Yin, S | 1 |
| Hu, H | 1 |
| Li, HY | 1 |
| Tang, ZM | 1 |
| Wang, Z | 2 |
| Lv, JM | 1 |
| Liu, XL | 1 |
| Liang, YL | 1 |
| Cheng, B | 1 |
| Gao, N | 1 |
| Ji, SR | 1 |
| Wu, Y | 1 |
| Wang, L | 2 |
| Zhang, Y | 9 |
| Zhong, J | 1 |
| Zhou, S | 1 |
| Xu, C | 1 |
| Yang, H | 1 |
| Cao, Q | 2 |
| Yuan, Z | 2 |
| Wu, X | 2 |
| Li, M | 4 |
| Chen, S | 2 |
| Tang, Y | 2 |
| Fang, W | 1 |
| He, T | 1 |
| Chen, X | 8 |
| Zhang, P | 2 |
| Hu, S | 1 |
| Yao, Y | 1 |
| Wei, ZY | 1 |
| Wang, SX | 1 |
| Wu, YC | 1 |
| Hu, Y | 1 |
| Yang, CC | 1 |
| Min, JL | 1 |
| Li, LY | 1 |
| Zhou, H | 3 |
| Yang, JF | 1 |
| Li, J | 9 |
| Xu, T | 1 |
| Thida, M | 1 |
| Li, B | 1 |
| Zhang, X | 5 |
| Chen, C | 2 |
| Rani, R | 1 |
| Sharma, A | 2 |
| Wang, J | 4 |
| Kumar, S | 1 |
| Polaki, US | 1 |
| Gandhi, CR | 1 |
| Xia, J | 2 |
| Lv, L | 2 |
| Liu, B | 1 |
| Wang, S | 2 |
| Zhang, S | 4 |
| Wu, Z | 3 |
| Yang, L | 2 |
| Bian, X | 2 |
| Wang, Q | 2 |
| Wang, K | 2 |
| Zhuge, A | 2 |
| Li, S | 4 |
| Yan, R | 2 |
| Jiang, H | 2 |
| Xu, K | 1 |
| Li, L | 4 |
| Yang, Y | 3 |
| Ju, C | 3 |
| Zhai, X | 1 |
| Dai, T | 1 |
| Chi, Z | 1 |
| Zhao, Z | 2 |
| Wu, G | 1 |
| Yang, S | 2 |
| Dong, D | 1 |
| Muhammad-Azam, F | 1 |
| Nur-Fazila, SH | 1 |
| Ain-Fatin, R | 1 |
| Noordin, MM | 1 |
| Yasmin, AR | 1 |
| Yimer, N | 1 |
| Jaeschke, H | 8 |
| Umbaugh, DS | 4 |
| Liu, Q | 1 |
| Tang, Q | 1 |
| Jing, X | 1 |
| Zhang, J | 4 |
| Xia, Y | 1 |
| Yan, J | 1 |
| Xu, Y | 4 |
| Li, Y | 9 |
| He, J | 1 |
| Mo, L | 1 |
| He, X | 3 |
| Kang, K | 1 |
| Pan, D | 1 |
| Sun, Y | 1 |
| Chang, B | 1 |
| Matsuyama, R | 1 |
| Okada, Y | 1 |
| Shimma, S | 1 |
| Gao, Y | 5 |
| Cui, L | 1 |
| He, H | 1 |
| Zheng, J | 3 |
| Mo, S | 1 |
| Zhou, X | 2 |
| Chu, S | 1 |
| Sun, X | 1 |
| Chen, N | 1 |
| Wang, H | 3 |
| Cai, X | 2 |
| Cai, H | 1 |
| Yang, Q | 1 |
| Guan, J | 1 |
| Deng, J | 2 |
| Chen, Z | 2 |
| Wang, YP | 1 |
| Wang, YD | 1 |
| Liu, YP | 1 |
| Cao, JX | 1 |
| Yang, ML | 1 |
| Wang, YF | 1 |
| Khan, A | 1 |
| Zhao, TR | 1 |
| Cheng, GG | 1 |
| Liao, CC | 1 |
| Yu, HP | 1 |
| Chou, AH | 1 |
| Lee, HC | 1 |
| Hu, LM | 1 |
| Liu, FC | 1 |
| Noda, T | 1 |
| Kato, R | 1 |
| Ozato, Y | 1 |
| Kawai, Y | 1 |
| Yamamoto, M | 1 |
| Kagawa, Y | 1 |
| Azuma, M | 1 |
| Yamamoto, K | 1 |
| Kusanagi, M | 1 |
| Uryu, K | 1 |
| Harada, H | 1 |
| Ijiri, Y | 1 |
| Hayashi, T | 1 |
| Tanaka, K | 1 |
| Adelusi, OB | 3 |
| Ramachandran, A | 6 |
| Lemasters, JJ | 1 |
| Black, SM | 1 |
| Zhang, Z | 7 |
| Han, Y | 1 |
| Zeng, C | 1 |
| Ma, J | 1 |
| Yao, C | 1 |
| Wang, Y | 6 |
| Gong, D | 1 |
| Feng, T | 1 |
| Wang, C | 4 |
| Wang, M | 5 |
| Zhu, J | 3 |
| Zhao, J | 4 |
| Ding, K | 1 |
| Hou, M | 1 |
| Hou, X | 1 |
| Dai, W | 1 |
| Li, Z | 3 |
| Liu, W | 4 |
| Bai, Z | 1 |
| Zhang, K | 1 |
| Fan, X | 1 |
| Wang, X | 2 |
| Zeng, L | 1 |
| Li, N | 1 |
| Han, Q | 1 |
| Lv, Y | 1 |
| Liu, Z | 4 |
| Nguyen, NT | 3 |
| Huang, EL | 1 |
| Sanchez Guerrero, G | 1 |
| Kwon, D | 1 |
| Son, SW | 1 |
| Kim, SH | 1 |
| Bae, JE | 1 |
| Lee, YH | 1 |
| Jung, YS | 1 |
| Xu, L | 1 |
| Jiang, J | 1 |
| Wen, Y | 2 |
| Jeong, JM | 1 |
| Emontzpohl, C | 1 |
| Atkins, CL | 2 |
| Kim, K | 1 |
| Jacobsen, EA | 1 |
| Yang, CM | 1 |
| Chien, MY | 1 |
| Wang, LY | 1 |
| Chuang, CH | 1 |
| Chen, CH | 1 |
| Xu, B | 1 |
| Hao, K | 1 |
| Wu, E | 1 |
| Nie, D | 1 |
| Zhang, G | 2 |
| Si, H | 1 |
| Yu, T | 2 |
| He, Y | 2 |
| Chen, H | 1 |
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| Ni, H | 1 |
| Ma, Y | 1 |
| Chen, Y | 7 |
| Li, C | 4 |
| Cao, R | 1 |
| Ma, L | 4 |
| Lei, Y | 2 |
| Luo, X | 1 |
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| Xie, M | 1 |
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| Heldring, MM | 1 |
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| Beltman, JB | 1 |
| Qin, S | 1 |
| Tian, J | 1 |
| Zhao, Y | 4 |
| Wang, D | 2 |
| Wang, F | 2 |
| Meng, J | 1 |
| Liu, M | 2 |
| Liang, A | 1 |
| Liu, L | 1 |
| Zhou, L | 1 |
| Soder, RP | 1 |
| Adelusi, O | 1 |
| Robarts, DR | 2 |
| Woolbright, B | 1 |
| Duan, L | 1 |
| Abhyankar, S | 1 |
| Dawn, B | 1 |
| Apte, U | 2 |
| Sun, J | 1 |
| Jin, L | 1 |
| Liang, S | 1 |
| Luo, W | 1 |
| Li, G | 1 |
| Liang, G | 1 |
| Jiang, Y | 1 |
| Zhou, Y | 1 |
| Song, S | 1 |
| Fan, S | 2 |
| Huang, M | 2 |
| Bi, H | 1 |
| Hua, S | 1 |
| Du, Z | 1 |
| Zhang, D | 2 |
| Khan, NU | 1 |
| Zhou, M | 1 |
| He, YM | 1 |
| Shen, XL | 1 |
| Guo, YN | 1 |
| Liang, SS | 1 |
| Ding, KN | 1 |
| Lu, MH | 1 |
| Tang, LP | 1 |
| Lin, Z | 1 |
| Wang, G | 1 |
| Gu, W | 1 |
| Zhao, S | 1 |
| Shen, Z | 1 |
| Zheng, G | 1 |
| Chen, B | 1 |
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| Wan, CC | 1 |
| Yan, T | 1 |
| Wu, Q | 1 |
| Yu, P | 1 |
| Bi, Y | 1 |
| Guo, W | 1 |
| Duan, Z | 1 |
| Li, X | 7 |
| Gong, S | 4 |
| Song, T | 3 |
| Ge, J | 3 |
| Fu, K | 3 |
| Zheng, Y | 5 |
| You, K | 3 |
| Yang, Z | 3 |
| Tan, S | 3 |
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| Getachew, A | 3 |
| Pan, T | 3 |
| Zhuang, Y | 3 |
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| Lin, X | 3 |
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| Gong, Y | 3 |
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| Dai, WZ | 2 |
| Bai, ZF | 2 |
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| Zhan, XY | 2 |
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11 reviews available for acetaminophen and Chemical and Drug Induced Liver Injury, Chronic
| Article | Year |
|---|---|
Mesenchymal Stem Cell Therapy for Acetaminophen-related Liver Injury: A Systematic Review and Meta-analysis of Experimental Studies
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2022 |
Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Chemical a | 2022 |
[c-Jun N-terminal kinase signaling pathway in acetaminophen-induced liver injury].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Acute liver failure.
Topics: Acetaminophen; Acute-On-Chronic Liver Failure; Adult; Chemical and Drug Induced Liver Injury, Chroni | 2019 |
Transplantation of mesenchymal stem cells and their derivatives effectively promotes liver regeneration to attenuate acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2020 |
Successful treatment with tumor necrosis factor-α blockers for poison-induced liver injury: case report and literature review.
Topics: Acetaminophen; Amanitins; Chemical and Drug Induced Liver Injury, Chronic; Humans; Liver; Mushroom P | 2021 |
[Investigation of Predisposition Biomarkers to Identify Risk Factors for Drug-induced Liver Injury in Humans: Analyses of Endogenous Metabolites in an Animal Model Mimicking Human Responders to APAP-induced Hepatotoxicity].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Blood Glucose; Chemical and Drug Induc | 2015 |
Role of Stem Cells Transplantation in Tissue Regeneration After Acute or Chronic Acetaminophen Induced Liver Injury.
Topics: Acetaminophen; Acute Disease; Adipose Tissue; Antipyretics; Cell Differentiation; Chemical and Drug | 2016 |
An update on drug induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Chemical and Drug Induced Liver Inju | 2011 |
Mechanistic classification of liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Autoimmunity; Calcium; Chemical and Dru | 2005 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Bile; Bile Acids and Salts; Biotransformation; Cell Survival; Chemical and Drug Induc | 1986 |
1 trial available for acetaminophen and Chemical and Drug Induced Liver Injury, Chronic
| Article | Year |
|---|---|
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2022 |
107 other studies available for acetaminophen and Chemical and Drug Induced Liver Injury, Chronic
| Article | Year |
|---|---|
Trimethylamine N-oxide exacerbates acetaminophen-induced liver injury by interfering with macrophage-mediated liver regeneration.
Topics: Acetaminophen; Aged; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Live | 2022 |
C-Reactive Protein Protects Against Acetaminophen-Induced Liver Injury by Preventing Complement Overactivation.
Topics: Acetaminophen; Animals; C-Reactive Protein; Chemical and Drug Induced Liver Injury; Chemical and Dru | 2022 |
Enhanced therapeutic efficacy of a novel self-micellizing nanoformulation-loading fisetin against acetaminophen-induced liver injury.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury, Chronic; Flavonoids; Flavonols; Humans; Liver | 2021 |
CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2021 |
Deletion of p38γ attenuates ethanol consumption- and acetaminophen-induced liver injury in mice through promoting Dlg1.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Echinacoside alleviates acetaminophen-induced liver injury by attenuating oxidative stress and inflammatory cytokines in mice.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Chemical and Drug Indu | 2021 |
Endotoxin-Stimulated Hepatic Stellate Cells Augment Acetaminophen-Induced Hepatocyte Injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Akkermansia muciniphila Ameliorates Acetaminophen-Induced Liver Injury by Regulating Gut Microbial Composition and Metabolism.
Topics: Acetaminophen; Akkermansia; Animals; Bacteria; Chemical and Drug Induced Liver Injury, Chronic; Fatt | 2022 |
Sulfation in Acetaminophen-Induced Liver Injury: Friend or Foe?
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury, Chronic; Drug-Related Side Effects and Advers | 2022 |
Naringin alleviates acetaminophen-induced acute liver injury by activating Nrf2 via CHAC2 upregulation.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Inju | 2022 |
Prophylactic effect of edible bird's nest on acetaminophen-induced liver injury response in mice model.
Topics: Acetaminophen; Animals; Biological Products; Birds; Chemical and Drug Induced Liver Injury, Chronic; | 2022 |
Protection against acetaminophen-induced liver injury with MG53: Muscle-liver axis and necroptosis.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chron | 2022 |
Mesencephalic astrocyte-derived neurotrophic factor protects against paracetamol -induced liver injury by inhibiting PERK-ATF4-CHOP signaling pathway.
Topics: Acetaminophen; Animals; Apoptosis; Astrocytes; Chemical and Drug Induced Liver Injury, Chronic; Endo | 2022 |
FTY720 attenuates APAP‑induced liver injury via the JAK2/STAT3 signaling pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Metabolite alteration analysis of acetaminophen-induced liver injury using a mass microscope.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chron | 2022 |
Combination of monoammonium glycyrrhizinate and cysteine hydrochloride protects mice against acetaminophen-induced liver injury via Keap1/Nrf2/ARE pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
6'-
Topics: Acetaminophen; Animals; Antioxidants; Arbutin; Caffeic Acids; Chemical and Drug Induced Liver Injury | 2022 |
Gastrodin Alleviates Acetaminophen-Induced Liver Injury in a Mouse Model Through Inhibiting MAPK and Enhancing Nrf2 Pathways.
Topics: Acetaminophen; Animals; Antioxidants; Benzyl Alcohols; Chemical and Drug Induced Liver Injury; Chemi | 2022 |
Decreased plasma acetaminophen glucuronide/acetaminophen concentration ratio warns the onset of acetaminophen-induced liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chemical and D | 2022 |
The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Reply to: "Protection against acetaminophen-induced liver injury with MG53: Muscle-liver axis and necroptosis".
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chron | 2022 |
Anti-TLR4 IgG2 Prevents Acetaminophen-induced Acute Liver Injury through the Toll-like Receptor 4/MAPKs Signaling Pathway in Mice.
Topics: Acetaminophen; Animals; Antioxidants; Caspase 3; Chemical and Drug Induced Liver Injury, Chronic; Li | 2023 |
Alterations in circadian rhythms aggravate Acetaminophen-induced liver injury in mice by influencing Acetaminophen metabolization and increasing intestinal permeability.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Recovered Hepatocytes Promote Macrophage Apoptosis Through CXCR4 After Acetaminophen-Induced Liver Injury in Mice.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2022 |
Effects of dietary restriction on hepatic sulfur-containing amino acid metabolism and its significance in acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Chemical and Drug Indu | 2022 |
Eosinophils protect against acetaminophen-induced liver injury through cyclooxygenase-mediated IL-4/IL-13 production.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Goji Ferment Ameliorated Acetaminophen-Induced Liver Injury in vitro and in vivo.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury, Chronic; Glutathione; | 2023 |
Topics: Acetaminophen; Animals; Broussonetia; Chemical and Drug Induced Liver Injury; Chemical and Drug Indu | 2022 |
Polysaccharide from Echinacea purpurea plant ameliorates oxidative stress-induced liver injury by promoting Parkin-dependent autophagy.
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2022 |
Inhibition of BTK improved APAP-induced liver injury via suppressing proinflammatory macrophages activation by restoring mitochondrion function.
Topics: Acetaminophen; Agammaglobulinaemia Tyrosine Kinase; Animals; Chemical and Drug Induced Liver Injury; | 2022 |
Unraveling the effect of intra- and intercellular processes on acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Ultra-performance chromatography-electrospray tandem mass spectrometry analysis of bile acid profiles in the enterohepatic circulation following geniposide and acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Bile Acids and Salts; Biomarkers; Chemical and Drug Induced Liver Injury, Ch | 2022 |
Novel pterostilbene-loaded pro-phytomicelles: preclinical pharmacokinetics, distribution, and treatment efficacy against acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury, Chronic; Cytokines; HMGB1 Protein; L | 2022 |
Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Inju | 2022 |
Diacerein protects liver against APAP-induced injury via targeting JNK and inhibiting JNK-mediated oxidative stress and apoptosis.
Topics: Acetaminophen; Animals; Anthraquinones; Apoptosis; Chemical and Drug Induced Liver Injury; Chemical | 2022 |
St. John's Wort Exacerbates Acetaminophen-Induced Liver Injury by Activation of PXR and CYP-Mediated Bioactivation.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury, Chronic; Cytochrome P-450 CYP2E1; Cy | 2022 |
Astaxanthin Activated the Nrf2/HO-1 Pathway to Enhance Autophagy and Inhibit Ferroptosis, Ameliorating Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Acetylcysteine; Autophagy; Chemical and Drug Induced Liver Injury; Chemical and Drug | 2022 |
Yinhuang oral liquid protects acetaminophen-induced acute liver injury by regulating the activation of autophagy and Nrf2 signaling.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransfera | 2022 |
Exploration of the Protective Mechanism of Naringin in the Acetaminophen-Induced Hepatic Injury by Metabolomics.
Topics: Acetaminophen; Amino Acids; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injur | 2022 |
Naringin regulates mitochondrial dynamics to protect against acetaminophen-induced hepatotoxicity by activating the AMPK/Nrf2 signaling pathway in vitro.
Topics: Acetaminophen; Alanine; Alanine Transaminase; AMP-Activated Protein Kinases; Animals; Aspartate Amin | 2022 |
Schisandrin B ameliorates acute liver injury by regulating EGFR-mediated activation of autophagy.
Topics: Acetaminophen; Autophagy; Chemical and Drug Induced Liver Injury, Chronic; ErbB Receptors; Humans; M | 2023 |
Schisandrin B ameliorates acute liver injury by regulating EGFR-mediated activation of autophagy.
Topics: Acetaminophen; Autophagy; Chemical and Drug Induced Liver Injury, Chronic; ErbB Receptors; Humans; M | 2023 |
Schisandrin B ameliorates acute liver injury by regulating EGFR-mediated activation of autophagy.
Topics: Acetaminophen; Autophagy; Chemical and Drug Induced Liver Injury, Chronic; ErbB Receptors; Humans; M | 2023 |
Schisandrin B ameliorates acute liver injury by regulating EGFR-mediated activation of autophagy.
Topics: Acetaminophen; Autophagy; Chemical and Drug Induced Liver Injury, Chronic; ErbB Receptors; Humans; M | 2023 |
Schisandrin B ameliorates acute liver injury by regulating EGFR-mediated activation of autophagy.
Topics: Acetaminophen; Autophagy; Chemical and Drug Induced Liver Injury, Chronic; ErbB Receptors; Humans; M | 2023 |
Schisandrin B ameliorates acute liver injury by regulating EGFR-mediated activation of autophagy.
Topics: Acetaminophen; Autophagy; Chemical and Drug Induced Liver Injury, Chronic; ErbB Receptors; Humans; M | 2023 |
Schisandrin B ameliorates acute liver injury by regulating EGFR-mediated activation of autophagy.
Topics: Acetaminophen; Autophagy; Chemical and Drug Induced Liver Injury, Chronic; ErbB Receptors; Humans; M | 2023 |
Schisandrin B ameliorates acute liver injury by regulating EGFR-mediated activation of autophagy.
Topics: Acetaminophen; Autophagy; Chemical and Drug Induced Liver Injury, Chronic; ErbB Receptors; Humans; M | 2023 |
Schisandrin B ameliorates acute liver injury by regulating EGFR-mediated activation of autophagy.
Topics: Acetaminophen; Autophagy; Chemical and Drug Induced Liver Injury, Chronic; ErbB Receptors; Humans; M | 2023 |
Neutralizing serum amyloid a protects against sinusoidal endothelial cell damage and platelet aggregation during acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Neutralizing serum amyloid a protects against sinusoidal endothelial cell damage and platelet aggregation during acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Neutralizing serum amyloid a protects against sinusoidal endothelial cell damage and platelet aggregation during acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Neutralizing serum amyloid a protects against sinusoidal endothelial cell damage and platelet aggregation during acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Wolfberry enhanced the abundance of Akkermansia muciniphila by YAP1 in mice with acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Wolfberry enhanced the abundance of Akkermansia muciniphila by YAP1 in mice with acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Wolfberry enhanced the abundance of Akkermansia muciniphila by YAP1 in mice with acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Wolfberry enhanced the abundance of Akkermansia muciniphila by YAP1 in mice with acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
[Schisandrin C improves acetaminophen-induced liver injury in mice by regulating Nrf2 signaling pathway].
Topics: Acetaminophen; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2022 |
[Schisandrin C improves acetaminophen-induced liver injury in mice by regulating Nrf2 signaling pathway].
Topics: Acetaminophen; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2022 |
[Schisandrin C improves acetaminophen-induced liver injury in mice by regulating Nrf2 signaling pathway].
Topics: Acetaminophen; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2022 |
[Schisandrin C improves acetaminophen-induced liver injury in mice by regulating Nrf2 signaling pathway].
Topics: Acetaminophen; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2022 |
Paeoniflorin Protects against Acetaminophen-Induced Liver Injury in Mice via JNK Signaling Pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Paeoniflorin Protects against Acetaminophen-Induced Liver Injury in Mice via JNK Signaling Pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Paeoniflorin Protects against Acetaminophen-Induced Liver Injury in Mice via JNK Signaling Pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Paeoniflorin Protects against Acetaminophen-Induced Liver Injury in Mice via JNK Signaling Pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Water extract from Herpetospermum pedunculosum attenuates oxidative stress and ferroptosis induced by acetaminophen via regulating Nrf2 and NF-κB pathways.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Growth differentiation factor 15 is dispensable for acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
The palliative effect of mulberry leaf and olive leaf ethanolic extracts on hepatic CYP2E1 and caspase-3 immunoexpression and oxidative damage induced by paracetamol in male rats.
Topics: Acetaminophen; Animals; Antioxidants; Caspase 3; Chemical and Drug Induced Liver Injury; Chemical an | 2023 |
Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
EGR1 is crucial for the chlorogenic acid-provided promotion on liver regeneration and repair after APAP-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Polymeric nano-micelle of carbon monoxide donor SMA/CORM2 ameliorates acetaminophen-induced liver injury via suppressing HMGB1/TLR4 signaling pathway.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Carbon Monoxide; Chemical and Drug Induced Liver I | 2023 |
[Discovery of miRNA and target signal molecules involved in inhibition of chlorogenic acid on N-acetyl-p-aminophenol-induced hepatotoxicity based on microRNA array].
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury, Chronic; Chlor | 2023 |
Potential biomarkers and metabolomics of acetaminophen-induced liver injury during alcohol consumption: A preclinical investigation on C57/BL6 mice.
Topics: Acetaminophen; Alcohol Drinking; Amino Acids; Animals; Biomarkers; Chemical and Drug Induced Liver I | 2023 |
Mitoquinone protects against acetaminophen-induced liver injury in an FSP1-dependent and GPX4-independent manner.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Dose-dependent pleiotropic role of neutrophils during acetaminophen-induced liver injury in male and female mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Pien Tze Huang attenuated acetaminophen-induced liver injury by autophagy mediated-NLRP3 inflammasome inhibition.
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2023 |
Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Bifidobacterium longum R0175 protects mice against APAP-induced liver injury by modulating the Nrf2 pathway.
Topics: Acetaminophen; Animals; Bifidobacterium longum; Chemical and Drug Induced Liver Injury; Chemical and | 2023 |
Role of HNF4alpha-cMyc interaction in liver regeneration and recovery after acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Circulating Cell-Free DNAs as a Biomarker and Therapeutic Target for Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Chemical and Drug Induce | 2023 |
Altered fibrinogen γ-chain cross-linking in mutant fibrinogen-γ
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury, Chronic; Fibrin; Fibrinogen; Integri | 2023 |
Migration inhibitory factor and cluster of differentiation 74-mediated dendritic cell apoptosis exacerbates acute acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury, Chronic; Dendritic Cells; | 2023 |
Celastrol-loaded biomimetic nanodrug ameliorates APAP-induced liver injury through modulating macrophage polarization.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Biomimetics; Chemical and Drug Induced Liver Injur | 2023 |
Absence of Increased Susceptibility to Acetaminophen-Induced Liver Injury in a Diet-Induced NAFLD Mouse Model.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
MnO
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury, Chronic; Humans; Liver; Manganese Compounds; | 2023 |
Single-cell RNA sequencing to reveal non-parenchymal cell heterogeneity and immune network of acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Protection of taraxasterol against acetaminophen-induced liver injury elucidated through network pharmacology and in vitro and in vivo experiments.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
The hepatoprotective effect of Sophora viciifolia fruit extract against acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury, Chronic; Cytochrome P- | 2023 |
Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3β phosphorylation and mitochondrial translocation.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury, Chronic; Glycogen Synthase Kinase 3 | 2023 |
The Effect of Curcumin Nanoparticles on Paracetamol-induced Liver Injury in Male Wistar Rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury, Chronic; Curcumin; Male; Nanoparticl | 2023 |
USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury, Chronic; Kelch-Like ECH-Associated P | 2023 |
Neutrophils exacerbate acetaminophen-induced liver injury by producing cytotoxic interferon-γ.
Topics: Acetaminophen; Animals; CD8-Positive T-Lymphocytes; Chemical and Drug Induced Liver Injury; Chemical | 2023 |
Bioinformatics approach and experimental validation reveal the hepatoprotective effect of pachyman against acetaminophen-associated liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury, Chronic; Computational Biology; Cyto | 2023 |
Ratiometric Fluorescent Sensors Illuminate Cellular Magnesium Imbalance in a Model of Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury, Chronic; Fluorescent Dyes; Humans; Magnesium | 2023 |
Fasudil inhibits the expression of C/EBP homologous protein to protect against liver injury in acetaminophen-overdosed mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Ethanol Extract of
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Chemical and Drug Induced Liver Injury; Chemi | 2023 |
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Antioxidants; Cell Survival; Chemical and Dru | 2019 |
Acetaminophen induces programmed necrosis.
Topics: Acetaminophen; Apoptosis; Cell Death; Chemical and Drug Induced Liver Injury, Chronic; Humans; Liver | 2019 |
Shoot aqueous extract of
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury, Chronic; Manihot; Rats | 2021 |
Acetaminophen Hepatotoxicity: Strong Offense and Weakened Defense.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2020 |
Differential hepatoprotective role of the cannabinoid CB
Topics: Acetaminophen; Animals; Cannabinoids; Chemical and Drug Induced Liver Injury, Chronic; Disease Model | 2020 |
Role of ferroptosis in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cell Death; Chemical and Drug Induced Liver Injury, Chronic | 2020 |
Response to the opinion letter entitled Role of Ferroptosis in Acetaminophen Hepatotoxicity by Yamada et al.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cell Death; Chemical and Drug Induced Liver Injury, Chronic | 2020 |
Modification of acetaminophen-induced hepatotoxicity by autophagy.
Topics: Acetaminophen; Autophagy; Chemical and Drug Induced Liver Injury, Chronic; Humans; Liver | 2020 |
Letter to the Editor: Does c-Jun N-Terminal Kinase Regulate Acetaminophen Hepatotoxicity by Modulating Nuclear Factor Erythroid 2-Related Factor 2-Dependent Genes or Mitochondrial Oxidant Stress?
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury, Chronic; JNK Mitogen-Activated Prote | 2021 |
Isatidis Folium alleviates acetaminophen-induced liver injury in mice by enhancing the endogenous antioxidant system.
Topics: Acetaminophen; Animals; Antioxidants; Benzoquinones; Chemical and Drug Induced Liver Injury; Chemica | 2020 |
Baicalin promotes liver regeneration after acetaminophen-induced liver injury by inducing NLRP3 inflammasome activation.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2020 |
The role of alcohol consumption on acetaminophen induced liver injury: Implications from a mathematical model.
Topics: Acetaminophen; Alcohol Drinking; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced L | 2021 |
Protective effect of ISO-1 with inhibition of RIPK3 up-regulation and neutrophilic accumulation on acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Acetates; Animals; Chemical and Drug Induced Liver Injury, Chronic; Humans; Male; Mic | 2021 |
Nano-designed carbon monoxide donor SMA/CORM2 exhibits protective effect against acetaminophen induced liver injury through macrophage reprograming and promoting liver regeneration.
Topics: Acetaminophen; Animals; Carbon Monoxide; Chemical and Drug Induced Liver Injury, Chronic; Liver; Liv | 2021 |
Kushenol C Prevents Tert-Butyl Hydroperoxide and Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Cell Line, | 2021 |
A mouse monoclonal antibody against influenza C virus attenuates acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Acetyl-CoA C-Acyltransferase; Animals; Antibodies, Monoclonal; Antibody Specificity; | 2021 |
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2021 |
Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment.
Topics: Acetaminophen; Animals; Blood Platelets; Chemical and Drug Induced Liver Injury, Chronic; Chitinase- | 2021 |
Glabridin attenuates paracetamol-induced liver injury in mice via CYP2E1-mediated inhibition of oxidative stress.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Protective Role of microRNA-31 in Acetaminophen-Induced Liver Injury: A Negative Regulator of c-Jun N-Terminal Kinase (JNK) Signaling Pathway.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury, Chronic; Disease Models, | 2021 |
Alterations of Cytochrome P450-Mediated Drug Metabolism during Liver Repair and Regeneration after Acetaminophen-Induced Liver Injury in Mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Effect of carvedilol versus propranolol on acute and chronic liver toxicity in rats.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Alanine Transaminase; Animals; Aspartate Aminotransferas | 2021 |
An Unexpected Role of Cholesterol Sulfotransferase and its Regulation in Sensitizing Mice to Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury, Chronic; Disease Mo | 2019 |
Long non-coding RNAs play regulatory roles in acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug Induced Liver Injury, | 2019 |
Mathematical modelling of chronic acetaminophen metabolism and liver injury.
Topics: Acetaminophen; Alanine Transaminase; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransfe | 2014 |
Carbamoyl phosphate synthetase-1 is a rapid turnover biomarker in mouse and human acute liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Biomarkers; Carbamoyl-Phosphate Synthase (A | 2014 |
Clinical course of repeated supratherapeutic ingestion of acetaminophen.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Arabia; Chemical and Drug Induced Liver Injury | 2011 |
Liver injury associated with the beta-interferons for MS.
Topics: Acetaminophen; Alanine Transaminase; Chemical and Drug Induced Liver Injury, Chronic; Humans; Interf | 2004 |
Dietary steatotic liver attenuates acetaminophen hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2006 |
Mild hepatitis at recommended doses of acetaminophen in patients with evidence of constitutionally enhanced cytochrome P450 system activity.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury, Chronic; Cyt | 2008 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |