acetaminophen has been researched along with Cataract in 25 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen (APAP) is biotransformed by hepatic cytochrome P450 (CYP) enzymes to the cataractogenic metabolite N-acetyl-p-benzoquinone imine (NAPQI)." | 7.72 | Cellular events preceding acetaminophen cataractogenesis studied by confocal fluorescence microscopy. ( Mathur, P; Peshenko, IV; Shichi, H, 2003) |
| "Injection of acetaminophen (APAP) (350 mg/kg body weight) into C57BL/6 mice in which cytochrome P450 (CYP) 1A1/1A2 had been induced produced acute cataract and other ocular tissue damage." | 7.70 | Prevention of acetaminophen-induced cataract by a combination of diallyl disulfide and N-acetylcysteine. ( Shichi, H; Zhao, C, 1998) |
| "Acetaminophen, an analgesic/antipyretic, is metabolized by hepatic cytochrome P450 to N -acetyl- p -benzoquinone imine (NAPQI), which is transported by blood circulation to the eye and induces anterior cortical cataract in mice." | 7.70 | Cataract formation by a semiquinone metabolite of acetaminophen in mice: possible involvement of Ca(2+)and calpain activation. ( Qian, W; Shichi, H, 2000) |
| "C57BL/6 and DBA/2 mice are, respectively, susceptible and resistant both to the induction of aryl hydrocarbon hydroxylase (cytochrome P450 1A1, or CYP1A1) and to the cataractogenicity of acetaminophen, which may involve its bioactivation to a toxic reactive intermediate, catalysed by P450 and (or) prostaglandin H synthase (PHS)." | 7.69 | In vivo murine studies on the biochemical mechanism of acetaminophen cataractogenicity. ( Lubek, BM; Wells, PG; Wilson, B; Winn, LM, 1995) |
| "To assess the efficacy of 2-mercaptoethanol/L-cysteine mixed disulfide (CySSME) as an L-cysteine prodrug suitable for glutathione biosynthesis in rat lenses in vitro, as an agent for the prevention of acetaminophen- and naphthalene-induced murine cataract in genetically-susceptible mice, and as an agent for maintenance of near-normal glutathione levels in lenses and livers of mice subjected to acetaminophen and naphthalene at cataractogenic doses." | 7.69 | Prevention of acetaminophen- and naphthalene-induced cataract and glutathione loss by CySSME. ( Cohen, JF; Holleschau, AM; Nagasawa, HT; Rathbun, WB, 1996) |
| " Acetaminophen injected into C57BL6 mice (responsive strain) that had been pretreated with beta-naphthoflavone produced cataract." | 7.69 | Histocytological study on the possible mechanism of acetaminophen cataractogenesis in mouse eye. ( Shichi, H; Zhao, C, 1995) |
| "Evidence from epidemiological, in vitro and animal studies has accumulated to support the idea that aspirin, ibuprofen and paracetamol protect against cataract." | 7.68 | Prevention of cataract in diabetic rats by aspirin, paracetamol (acetaminophen) and ibuprofen. ( Blakytny, R; Harding, JJ, 1992) |
| "There is evidence that ibuprofen and paracetamol can act as anti-cataract drugs." | 7.68 | Investigations of ibuprofen and paracetamol binding to lens proteins to explore their protective role against cataract. ( Harding, JJ; Shyadehi, AZ, 1991) |
| "Results of a case-control of 423 cataract patients and 608 controls in Oxfordshire shows that the protective effect against cataract associated with consumption of aspirin-like analgesics (aspirin, paracetamol and ibuprofen family) is manifest even at low doses." | 7.67 | Protection against cataract by aspirin, paracetamol and ibuprofen. ( Egerton, M; Harding, JJ; Harding, RS, 1989) |
| "The results of a case-control study of 300 cataract patients and 609 controls indicate that long-term use of aspirin-like analgesics halves the risk of cataract." | 7.67 | Do aspirin-like analgesics protect against cataract? A case-control study. ( Harding, JJ; van Heyningen, R, 1986) |
| "Acetaminophen can be enzymatically bioactivated, which may play a role in cataractogenesis." | 7.67 | Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits. ( Avaria, M; Basu, PK; Lubek, BM; Wells, PG, 1988) |
| "Acetaminophen has been shown to be cataractogenic in mice and rabbits." | 7.67 | Metabolic evidence for the involvement of enzymatic bioactivation in the cataractogenicity of acetaminophen in genetically susceptible (C57BL/6) and resistant (DBA/2) murine strains. ( Basu, PK; Lubek, BM; Wells, PG, 1988) |
| "Acenaphthylene treatment of young DBA2 mice resulted in a 2-fold increase in cytochrome P450 1A2-dependent methoxyresorufin O-demethylase activity in the liver." | 5.31 | Acetaminophen produces cataract in DBA2 mice by Ah receptor-independent induction of CYP1A2. ( Qian, W; Shichi, H, 2000) |
| " Genetic differences in acetaminophen- and naphthalene-induced cataract formation and and other ocular degeneration are shown to be related to the [Ah] complex." | 4.76 | Genetic differences in drug metabolism associated with ocular toxicity. ( Nebert, DW; Shichi, H, 1982) |
| " Our anesthetic protocol for strabismus surgery included postoperative nausea and vomiting prevention using dexamethasone and ondansetron." | 3.91 | Prospective evaluation of anesthetic protocols during pediatric ophthalmic surgery. ( Couret, C; Ducloyer, JB; Le Meur, G; Lebranchu, P; Lejus-Bourdeau, C; Magne, C; Weber, M, 2019) |
| " Cataract formation was induced in vitro by incubation in high-glucose solutions and in vivo by acetaminophen toxicity." | 3.73 | Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice. ( Ruiz-Ederra, J; Verkman, AS, 2006) |
| "Acetaminophen (APAP) is biotransformed by hepatic cytochrome P450 (CYP) enzymes to the cataractogenic metabolite N-acetyl-p-benzoquinone imine (NAPQI)." | 3.72 | Cellular events preceding acetaminophen cataractogenesis studied by confocal fluorescence microscopy. ( Mathur, P; Peshenko, IV; Shichi, H, 2003) |
| "Injection of acetaminophen (APAP) (350 mg/kg body weight) into C57BL/6 mice in which cytochrome P450 (CYP) 1A1/1A2 had been induced produced acute cataract and other ocular tissue damage." | 3.70 | Prevention of acetaminophen-induced cataract by a combination of diallyl disulfide and N-acetylcysteine. ( Shichi, H; Zhao, C, 1998) |
| "Acetaminophen, an analgesic/antipyretic, is metabolized by hepatic cytochrome P450 to N -acetyl- p -benzoquinone imine (NAPQI), which is transported by blood circulation to the eye and induces anterior cortical cataract in mice." | 3.70 | Cataract formation by a semiquinone metabolite of acetaminophen in mice: possible involvement of Ca(2+)and calpain activation. ( Qian, W; Shichi, H, 2000) |
| "C57BL/6 and DBA/2 mice are, respectively, susceptible and resistant both to the induction of aryl hydrocarbon hydroxylase (cytochrome P450 1A1, or CYP1A1) and to the cataractogenicity of acetaminophen, which may involve its bioactivation to a toxic reactive intermediate, catalysed by P450 and (or) prostaglandin H synthase (PHS)." | 3.69 | In vivo murine studies on the biochemical mechanism of acetaminophen cataractogenicity. ( Lubek, BM; Wells, PG; Wilson, B; Winn, LM, 1995) |
| "To assess the efficacy of 2-mercaptoethanol/L-cysteine mixed disulfide (CySSME) as an L-cysteine prodrug suitable for glutathione biosynthesis in rat lenses in vitro, as an agent for the prevention of acetaminophen- and naphthalene-induced murine cataract in genetically-susceptible mice, and as an agent for maintenance of near-normal glutathione levels in lenses and livers of mice subjected to acetaminophen and naphthalene at cataractogenic doses." | 3.69 | Prevention of acetaminophen- and naphthalene-induced cataract and glutathione loss by CySSME. ( Cohen, JF; Holleschau, AM; Nagasawa, HT; Rathbun, WB, 1996) |
| " Acetaminophen injected into C57BL6 mice (responsive strain) that had been pretreated with beta-naphthoflavone produced cataract." | 3.69 | Histocytological study on the possible mechanism of acetaminophen cataractogenesis in mouse eye. ( Shichi, H; Zhao, C, 1995) |
| "Aldose reductase catalyzes the NADPH-linked reduction of hexoses to their respective sugar-alcohols, which are involved in the pathogenesis of "sugar-cataracts"." | 3.68 | Effects of G-6-PD deficiency, experimentally induced or genetically transmitted, on the sorbitol pathway activity. In vitro and in vivo studies. ( Alvarez, A; Chávez, M; Chávez-Anaya, E; Medina, C; Medina, MD; Mendoza, R; Ramírez, MG; Sáenz, G; Vaca, G; Vargas, M, 1992) |
| "Evidence from epidemiological, in vitro and animal studies has accumulated to support the idea that aspirin, ibuprofen and paracetamol protect against cataract." | 3.68 | Prevention of cataract in diabetic rats by aspirin, paracetamol (acetaminophen) and ibuprofen. ( Blakytny, R; Harding, JJ, 1992) |
| "There is evidence that ibuprofen and paracetamol can act as anti-cataract drugs." | 3.68 | Investigations of ibuprofen and paracetamol binding to lens proteins to explore their protective role against cataract. ( Harding, JJ; Shyadehi, AZ, 1991) |
| "Results of a case-control of 423 cataract patients and 608 controls in Oxfordshire shows that the protective effect against cataract associated with consumption of aspirin-like analgesics (aspirin, paracetamol and ibuprofen family) is manifest even at low doses." | 3.67 | Protection against cataract by aspirin, paracetamol and ibuprofen. ( Egerton, M; Harding, JJ; Harding, RS, 1989) |
| "The results of a case-control study of 300 cataract patients and 609 controls indicate that long-term use of aspirin-like analgesics halves the risk of cataract." | 3.67 | Do aspirin-like analgesics protect against cataract? A case-control study. ( Harding, JJ; van Heyningen, R, 1986) |
| "Acetaminophen can be enzymatically bioactivated, which may play a role in cataractogenesis." | 3.67 | Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits. ( Avaria, M; Basu, PK; Lubek, BM; Wells, PG, 1988) |
| "Acetaminophen has been shown to be cataractogenic in mice and rabbits." | 3.67 | Metabolic evidence for the involvement of enzymatic bioactivation in the cataractogenicity of acetaminophen in genetically susceptible (C57BL/6) and resistant (DBA/2) murine strains. ( Basu, PK; Lubek, BM; Wells, PG, 1988) |
| "Acenaphthylene treatment of young DBA2 mice resulted in a 2-fold increase in cytochrome P450 1A2-dependent methoxyresorufin O-demethylase activity in the liver." | 1.31 | Acetaminophen produces cataract in DBA2 mice by Ah receptor-independent induction of CYP1A2. ( Qian, W; Shichi, H, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (36.00) | 18.7374 |
| 1990's | 10 (40.00) | 18.2507 |
| 2000's | 5 (20.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ducloyer, JB | 1 |
| Couret, C | 1 |
| Magne, C | 1 |
| Lejus-Bourdeau, C | 1 |
| Weber, M | 1 |
| Le Meur, G | 1 |
| Lebranchu, P | 1 |
| HARLEY, JD | 1 |
| FARRAR, JF | 1 |
| GRAY, JB | 1 |
| DUNLOP, IC | 1 |
| Mathur, P | 1 |
| Peshenko, IV | 1 |
| Shichi, H | 9 |
| Miller, RA | 1 |
| Buehner, G | 1 |
| Chang, Y | 1 |
| Harper, JM | 1 |
| Sigler, R | 1 |
| Smith-Wheelock, M | 1 |
| Ruiz-Ederra, J | 1 |
| Verkman, AS | 1 |
| Nebert, DW | 3 |
| Tanaka, M | 1 |
| Jensen, NM | 2 |
| Wells, PG | 3 |
| Wilson, B | 1 |
| Winn, LM | 1 |
| Lubek, BM | 3 |
| Rathbun, WB | 2 |
| Holleschau, AM | 2 |
| Cohen, JF | 1 |
| Nagasawa, HT | 2 |
| Killen, CE | 1 |
| Zhao, C | 2 |
| Qian, W | 3 |
| Amin, RH | 1 |
| Gaasterland, DE | 1 |
| Ryan, AJ | 1 |
| Vaca, G | 1 |
| Ramírez, MG | 1 |
| Vargas, M | 1 |
| Mendoza, R | 1 |
| Chávez-Anaya, E | 1 |
| Medina, MD | 1 |
| Alvarez, A | 1 |
| Medina, C | 1 |
| Sáenz, G | 1 |
| Chávez, M | 1 |
| Blakytny, R | 1 |
| Harding, JJ | 4 |
| Shyadehi, AZ | 1 |
| Woollard, AC | 1 |
| Wolff, SP | 1 |
| Bascal, ZA | 1 |
| Egerton, M | 1 |
| Harding, RS | 1 |
| van Heyningen, R | 1 |
| Avaria, M | 1 |
| Basu, PK | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acetylsalicylic Acid Administered in Patients With Type 2 Diabetes Mellitus and Its Effect on the Antioxidant Enzyme System[NCT03341117] | Phase 3 | 21 participants (Actual) | Interventional | 2014-12-02 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for acetaminophen and Cataract
| Article | Year |
|---|---|
Genetic differences in drug metabolism associated with ocular toxicity.
Topics: Acetaminophen; Animals; Aryl Hydrocarbon Hydroxylases; Cataract; Cytochrome P-450 Enzyme System; Eye | 1982 |
24 other studies available for acetaminophen and Cataract
| Article | Year |
|---|---|
Prospective evaluation of anesthetic protocols during pediatric ophthalmic surgery.
Topics: Acetaminophen; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Intravenous; Anti-Anxiety Agen | 2019 |
AROMATIC DRUGS AND CONGENITAL CATARACTS.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Acetazolamide; Anti-Bacterial Agents; Cardiovascular Age | 1964 |
Cellular events preceding acetaminophen cataractogenesis studied by confocal fluorescence microscopy.
Topics: Acetaminophen; Animals; Calpain; Cataract; Glycoproteins; Lens, Crystalline; Male; Mice; Mice, Inbre | 2003 |
Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance.
Topics: Acetaminophen; Aging; Alanine Transaminase; Animals; Blood Glucose; Body Weight; Cataract; Diet; Ene | 2005 |
Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice.
Topics: Acetaminophen; Animals; Aquaporin 1; Body Water; Cataract; Drug Combinations; Epithelial Cells; Fluo | 2006 |
Genetic differences in cataract and other ocular abnormalities induced by paracetamol and naphthalene.
Topics: Acetaminophen; Administration, Oral; Animals; Cataract; Cytochrome P-450 Enzyme System; Enzyme Induc | 1980 |
In vivo murine studies on the biochemical mechanism of acetaminophen cataractogenicity.
Topics: Acetaminophen; Adult; Animals; Cataract; Dose-Response Relationship, Drug; Glutathione; Humans; In V | 1995 |
Prevention of acetaminophen- and naphthalene-induced cataract and glutathione loss by CySSME.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cataract; Chromatography, High Pressure Liquid; Cy | 1996 |
Maintenance of hepatic glutathione homeostasis and prevention of acetaminophen-induced cataract in mice by L-cysteine prodrugs.
Topics: Acetaminophen; Animals; Cataract; Cysteine; Glutathione; Homeostasis; Liver; Male; Mice; Mice, Inbre | 1996 |
Histocytological study on the possible mechanism of acetaminophen cataractogenesis in mouse eye.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; beta-Naphthoflavone; Cataract; Ciliary Body; Enzym | 1995 |
Prevention of acetaminophen-induced cataract by a combination of diallyl disulfide and N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Allyl Compounds; Animals; Antimutagenic Agents; | 1998 |
Cytotoxic metabolite of acetaminophen, N-acetyl-p-benzoquinone imine, produces cataract in DBA2 mice.
Topics: Acetaminophen; Administration, Topical; Animals; Benzoquinones; Cataract; Chromatin; Cilia; Cytochro | 1999 |
Acetaminophen produces cataract in DBA2 mice by Ah receptor-independent induction of CYP1A2.
Topics: Acenaphthenes; Acetaminophen; Animals; Cataract; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Sy | 2000 |
Cataract formation by a semiquinone metabolite of acetaminophen in mice: possible involvement of Ca(2+)and calpain activation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Calcium; Calpain; Cataract; Cytochr | 2000 |
Ah locus: genetic differences in susceptibility to cataracts induced by acetaminophen.
Topics: Acetaminophen; Animals; Aryl Hydrocarbon Hydroxylases; Cataract; Enzyme Induction; Methylcholanthren | 1978 |
In a mouse's eye.
Topics: Acetaminophen; Animals; Aryl Hydrocarbon Hydroxylases; Cataract; Humans; Methylcholanthrene; Mice; M | 1978 |
Effects of G-6-PD deficiency, experimentally induced or genetically transmitted, on the sorbitol pathway activity. In vitro and in vivo studies.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Aldehyde Reductase; Animals; Black People | 1992 |
Prevention of cataract in diabetic rats by aspirin, paracetamol (acetaminophen) and ibuprofen.
Topics: Acetaminophen; Animals; Aspirin; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Female; G | 1992 |
Investigations of ibuprofen and paracetamol binding to lens proteins to explore their protective role against cataract.
Topics: Acetaminophen; Animals; Cataract; Cattle; Chromatography, Affinity; Crystallins; Ibuprofen; Kinetics | 1991 |
Antioxidant characteristics of some potential anticataract agents. Studies of aspirin, paracetamol, and bendazac provide support for an oxidative component of cataract.
Topics: Acetaminophen; Ampyrone; Antioxidants; Aspirin; Biphenyl Compounds; Cataract; Chelating Agents; Eryt | 1990 |
Protection against cataract by aspirin, paracetamol and ibuprofen.
Topics: Acetaminophen; Aged; Aspirin; Cataract; England; Female; Humans; Ibuprofen; Male; Middle Aged; Risk | 1989 |
Do aspirin-like analgesics protect against cataract? A case-control study.
Topics: Acetaminophen; Aged; Analgesics; Aspirin; Cataract; Diabetes Complications; Epidemiologic Methods; F | 1986 |
Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits.
Topics: Acetaminophen; Animals; Cataract; Chemical and Drug Induced Liver Injury; Male; Methylcholanthrene; | 1988 |
Metabolic evidence for the involvement of enzymatic bioactivation in the cataractogenicity of acetaminophen in genetically susceptible (C57BL/6) and resistant (DBA/2) murine strains.
Topics: Acetaminophen; Animals; Biotransformation; Cataract; Cytochrome P-450 CYP1A2; Cytochromes; Glucurona | 1988 |