Page last updated: 2024-10-22

acetaminophen and Cardiovascular Diseases

acetaminophen has been researched along with Cardiovascular Diseases in 46 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Research Excerpts

ExcerptRelevanceReference
"Acetaminophen is widely regarded as a safe therapy for pain and fever in patients with cardiovascular disease and those taking anticoagulants."9.22Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Hypertension. ( FitzGerald, GA; Grosser, T; Spence, JD, 2022)
"The initiation of sodium-containing acetaminophen was associated with increased risks of CVD and all-cause mortality among individuals with or without hypertension."8.12Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension. ( Djousse, L; Lei, G; Li, X; Rosenberg, L; Wei, J; Zeng, C; Zhang, Y, 2022)
" We determined whether paracetamol or ibuprofen use is associated with major cardiovascular events (MACE) or major bleeding in 19 120 patients with recent ischemic stroke or transient ischemic attack of mainly atherothrombotic origin included in the Prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) trial."7.83Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke. ( Amarenco, P; Bousser, MG; Chamorro, A; Fisher, M; Ford, I; Fox, KM; Gonzalez-Valcarcel, J; Hennerici, MG; Labreuche, J; Mattle, HP; Rothwell, PM; Sissani, L; Steg, PG; Vicaut, E, 2016)
"To determine whether acetaminophen or an acetaminophen-codeine combination is associated with an increased risk of acute cerebrovascular and cardiovascular events (ACCEs) in patients with osteoarthritis."7.81Risk of Acute Cerebrovascular and Cardiovascular Events Among Users of Acetaminophen or an Acetaminophen-Codeine Combination in a Cohort of Patients with Osteoarthritis: A Nested Case-Control Study. ( Cricelli, C; Cricelli, I; Fanelli, A; Lapi, F; Lora Aprile, P; Piccinni, C; Roberto, G; Simonetti, M, 2015)
" Rather, dosing for adults who are older and/or have decompensated cirrhosis, advanced kidney failure, or analgesic-induced asthma that is known to be cross-sensitive to paracetamol, should be individualized in consultation with their physician, who may recommend a lower effective dose appropriate to the circumstances."6.82Why paracetamol (acetaminophen) is a suitable first choice for treating mild to moderate acute pain in adults with liver, kidney or cardiovascular disease, gastrointestinal disorders, asthma, or who are older. ( Alchin, J; Christo, PJ; Dhar, A; Siddiqui, K, 2022)
"Acetaminophen is widely regarded as a safe therapy for pain and fever in patients with cardiovascular disease and those taking anticoagulants."5.22Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Hypertension. ( FitzGerald, GA; Grosser, T; Spence, JD, 2022)
"Paracetamol (acetaminophen) is the most commonly used drug in the world, with a long record of use in acute and chronic pain."4.98Long-term adverse effects of paracetamol - a review. ( Dear, JW; MacIntyre, IM; McCrae, JC; Morrison, EE; Webb, DJ, 2018)
"Nonopioid analgesics, which include acetaminophen, aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and cyclooxygenase-2 (COX-2)-specific inhibitors (coxibs), are frequently used for the relief of mild-to-moderate pain."4.83Clinical implications of nonopioid analgesia for relief of mild-to-moderate pain in patients with or at risk for cardiovascular disease. ( Whelton, A, 2006)
"Effervescent formulations of paracetamol containing sodium bicarbonate have been reported to associate with increased blood pressure and a higher risk of cardiovascular diseases and all-cause mortality."4.31Sodium-based paracetamol: impact on blood pressure, cardiovascular events, and all-cause mortality. ( Canoy, D; Huang, J; Li, Y; Mamouei, M; Nazarzadeh, M; Neal, B; Rahimi, K; Rao, S; Salimi-Khorshidi, G; Schutte, AE; Smith, GD, 2023)
"The initiation of sodium-containing acetaminophen was associated with increased risks of CVD and all-cause mortality among individuals with or without hypertension."4.12Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension. ( Djousse, L; Lei, G; Li, X; Rosenberg, L; Wei, J; Zeng, C; Zhang, Y, 2022)
" We determined whether paracetamol or ibuprofen use is associated with major cardiovascular events (MACE) or major bleeding in 19 120 patients with recent ischemic stroke or transient ischemic attack of mainly atherothrombotic origin included in the Prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) trial."3.83Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke. ( Amarenco, P; Bousser, MG; Chamorro, A; Fisher, M; Ford, I; Fox, KM; Gonzalez-Valcarcel, J; Hennerici, MG; Labreuche, J; Mattle, HP; Rothwell, PM; Sissani, L; Steg, PG; Vicaut, E, 2016)
"To determine whether acetaminophen or an acetaminophen-codeine combination is associated with an increased risk of acute cerebrovascular and cardiovascular events (ACCEs) in patients with osteoarthritis."3.81Risk of Acute Cerebrovascular and Cardiovascular Events Among Users of Acetaminophen or an Acetaminophen-Codeine Combination in a Cohort of Patients with Osteoarthritis: A Nested Case-Control Study. ( Cricelli, C; Cricelli, I; Fanelli, A; Lapi, F; Lora Aprile, P; Piccinni, C; Roberto, G; Simonetti, M, 2015)
" Rather, dosing for adults who are older and/or have decompensated cirrhosis, advanced kidney failure, or analgesic-induced asthma that is known to be cross-sensitive to paracetamol, should be individualized in consultation with their physician, who may recommend a lower effective dose appropriate to the circumstances."2.82Why paracetamol (acetaminophen) is a suitable first choice for treating mild to moderate acute pain in adults with liver, kidney or cardiovascular disease, gastrointestinal disorders, asthma, or who are older. ( Alchin, J; Christo, PJ; Dhar, A; Siddiqui, K, 2022)
"We conducted a systematic literature review to assess the adverse event (AE) profile of paracetamol."2.53Paracetamol: not as safe as we thought? A systematic literature review of observational studies. ( Bernstein, I; Birrell, F; Buckner, S; Conaghan, PG; Constanti, M; Delgado Nunes, V; Doherty, M; Dziedzic, K; Latchem, S; Miller, P; Porcheret, M; Roberts, E; Wise, E; Zhang, W, 2016)
" Because NSAIDs are associated with adverse renal effects, they should be used cautiously in patients with advanced renal disease."2.43Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease. ( Johnson, J; Weinryb, J, 2006)
"Neuropathic pain was the most common indication (33."1.48Patterns of pain medication use in older individuals with cardiovascular disease. ( Dimassi, H; Kabbara, WK; Sheikh-Taha, M, 2018)
"Irreversible acute liver failure, defined as rise in prothrombin time >3 times normal, occurred 19."1.39A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival. ( Alibhai, H; Baker, LA; Chang, YM; Davies, NA; Jalan, R; L Priestnall, S; Leckie, PJ; Lee, KC; Mookerjee, RP; Palacios Jimenez, C; Stanzani, G, 2013)
" Etoricoxib is partly metabolised by the cytochrome P450 isoenzyme CYP 3A4 and increases the bioavailability of ethinylestradiol."1.34Etoricoxib: new drug. Avoid using cox-2 inhibitors for pain. ( , 2007)
" Moreover, we observed significant dose-response relations: Compared with nonusers, the RRs for a cardiovascular event among women who used > or =15 tablets per week were 1."1.33Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events. ( Albert, CM; Chae, CU; Chan, AT; Curhan, GC; Fuchs, CS; Manson, JE; Rexrode, KM; Rimm, EB; Willett, WC, 2006)
"We conduct a study to determine the rate of adverse events (anaphylactoid and cardiorespiratory) associated with the use of oral N-acetylcysteine by the intravenous route for the treatment of suspected acetaminophen poisoning and to examine specific variables that may be associated with adverse events."1.32What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning? ( Brizendine, EJ; Furbee, RB; Kao, LW; Kirk, MA; Mehta, NH; Skinner, JR, 2003)
" We explore the toxicities of OTC cough and cold medications, discuss mechanisms of dosing errors, and suggest why physicians should be more vigilant in specifically inquiring about OTCs when evaluating an ill child."1.31Toxicity of over-the-counter cough and cold medications. ( Gunn, VL; Liebelt, EL; Serwint, JR; Taha, SH, 2001)
"Four caffeine-treated rats had histologic evidence of acute myocardial infarction which was not found in any of the other rats."1.26Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine. ( Johansson, S, 1981)

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-19902 (4.35)18.7374
1990's0 (0.00)18.2507
2000's18 (39.13)29.6817
2010's17 (36.96)24.3611
2020's9 (19.57)2.80

Authors

AuthorsStudies
Novi, DRBS1
Vidigal, CB1
Moura, KF1
da Silva, DG1
Serafim, AFL1
Klein, RM1
Moreira, EG1
Gerardin, DCC1
Ceravolo, GS1
Zeng, C1
Rosenberg, L1
Li, X1
Djousse, L1
Wei, J1
Lei, G1
Zhang, Y4
Alchin, J1
Dhar, A1
Siddiqui, K1
Christo, PJ1
Spence, JD1
Grosser, T1
FitzGerald, GA1
Zhou, C1
Wu, Q1
Ye, Z1
Yang, S1
Liu, M1
He, P1
Qin, X1
Qutob, HMH1
Saad, RA1
Bali, H1
Osailan, A1
Jaber, J1
Alzahrani, E1
Alyami, J1
Elsayed, H1
Alserihi, R1
Shaikhomar, OA1
Divya, KM1
Savitha, DP1
Krishna, GA1
Dhanya, TM1
Mohanan, PV1
Shah, SF1
Jafry, AT1
Hussain, G1
Kazim, AH1
Ali, M1
Rivani, E1
Endraswari, PD1
Widodo, ADW1
Khalil, MR1
Guldberg, R1
Nørgård, BM1
Uldbjerg, N1
Wehberg, S1
Fowobaje, KR1
Mashood, LO1
Ekholuenetale, M1
Ibidoja, OJ1
Romagnoli, A1
D'Agostino, M1
Pavoni, E1
Ardiccioni, C1
Motta, S1
Crippa, P1
Biagetti, G1
Notarstefano, V1
Rexha, J1
Perta, N1
Barocci, S1
Costabile, BK1
Colasurdo, G1
Caucci, S1
Mencarelli, D1
Turchetti, C1
Farina, M1
Pierantoni, L1
La Teana, A1
Al Hadi, R1
Cicconardi, F1
Chinappi, M1
Trucchi, E1
Mancia, F1
Menzo, S1
Morozzo Della Rocca, B1
D'Annessa, I1
Di Marino, D1
Choya, A1
de Rivas, B1
Gutiérrez-Ortiz, JI1
López-Fonseca, R1
Xu, S1
Cheng, B1
Huang, Z1
Liu, T1
Li, Y2
Jiang, L1
Guo, W1
Xiong, J1
Amirazodi, M1
Daryanoosh, F1
Mehrabi, A1
Gaeini, A1
Koushkie Jahromi, M1
Salesi, M1
Zarifkar, AH1
Studeny, P1
Netukova, M1
Nemcokova, M1
Klimesova, YM1
Krizova, D1
Kang, H1
Tao, Y1
Zhang, Q1
Sha, D1
Chen, Y1
Yao, J1
Gao, Y1
Liu, J1
Ji, L1
Shi, P1
Shi, C1
Wu, YL1
Wright, AI1
M El-Metwaly, N1
A Katouah, H1
El-Desouky, MG1
El-Bindary, AA1
El-Bindary, MA1
Kostakis, ID1
Raptis, DA1
Davidson, BR1
Iype, S1
Nasralla, D1
Imber, C1
Sharma, D1
Pissanou, T1
Pollok, JM1
Hughes, AM1
Sanderson, E1
Morris, T1
Ayorech, Z1
Tesli, M1
Ask, H1
Reichborn-Kjennerud, T1
Andreassen, OA1
Magnus, P1
Helgeland, Ø1
Johansson, S2
Njølstad, P1
Davey Smith, G1
Havdahl, A1
Howe, LD1
Davies, NM1
Amrillah, T1
Prasetio, A1
Supandi, AR1
Sidiq, DH1
Putra, FS1
Nugroho, MA1
Salsabilla, Z1
Azmi, R1
Grammatikopoulos, P1
Bouloumis, T1
Steinhauer, S1
Mironov, VS2
Bazhenova, TA2
Manakin, YV2
Yagubskii, EB2
Yakushev, IA1
Gilmutdinov, IF1
Simonov, SV1
Lan, K1
Yang, H1
Zheng, J1
Hu, H1
Zhu, T1
Zou, X1
Hu, B1
Liu, H1
Olokede, O1
Wu, H1
Holtzapple, M1
Gungor, O1
Kose, M1
Ghaemi, R1
Acker, M1
Stosic, A1
Jacobs, R1
Selvaganapathy, PR1
Ludwig, N1
Yerneni, SS1
Azambuja, JH1
Pietrowska, M1
Widłak, P1
Hinck, CS1
Głuszko, A1
Szczepański, MJ1
Kärmer, T1
Kallinger, I1
Schulz, D1
Bauer, RJ1
Spanier, G1
Spoerl, S1
Meier, JK1
Ettl, T1
Razzo, BM1
Reichert, TE1
Hinck, AP1
Whiteside, TL1
Wei, ZL1
Juan, W1
Tong, D1
Juan, LX1
Sa, LY1
Jie, HFM1
Xiao, G1
Xiang, LG1
Jie, HM1
Xu, C1
Yu, DN1
Yao, ZX1
Bigdeli, F1
Gao, XM1
Cheng, X1
Li, JZ1
Zhang, JW1
Wang, W2
Guan, ZJ1
Bu, Y1
Liu, KG1
Morsali, A1
Das, R1
Paul, R1
Parui, A1
Shrotri, A1
Atzori, C1
Lomachenko, KA1
Singh, AK1
Mondal, J1
Peter, SC1
Florimbio, AR1
Coughlin, LN1
Bauermeister, JA1
Young, SD1
Zimmerman, MA1
Walton, MA1
Bonar, EE1
Demir, D1
Balci, AB1
Kahraman, N1
Sunbul, SA1
Gucu, A1
Seker, IB1
Badem, S1
Yuksel, A1
Ozyazicioglu, AF1
Goncu, MT1
Zhang, H1
Zhou, H1
Deng, Z1
Luo, L1
Ong, SP1
Wang, C1
Xin, H1
Whittingham, MS1
Zhou, G1
Maemura, R1
Wakamatsu, M1
Matsumoto, K1
Sakaguchi, H1
Yoshida, N1
Hama, A1
Yoshida, T1
Miwata, S1
Kitazawa, H1
Narita, K1
Kataoka, S1
Ichikawa, D1
Hamada, M1
Taniguchi, R1
Suzuki, K1
Kawashima, N1
Nishikawa, E1
Narita, A1
Okuno, Y1
Nishio, N1
Kato, K1
Kojima, S1
Morita, K1
Muramatsu, H1
Takahashi, Y1
Yirgu, A1
Mekonnen, Y1
Eyado, A1
Staropoli, A1
Vinale, F1
Zac, J1
Zac, S1
Pérez-Padilla, R1
Remigio-Luna, A1
Guzmán-Boulloud, N1
Gochicoa-Rangel, L1
Guzmán-Valderrábano, C1
Thirión-Romero, I1
Statsenko, ME1
Turkina, SV1
Barantsevich, ER1
Karakulova, YV1
Baranova, NS1
Morzhukhina, MV1
Wang, Q1
Gu, Y1
Chen, C1
Qiao, L1
Pan, F1
Song, C1
Canetto, SS1
Entilli, L1
Cerbo, I1
Cipolletta, S1
Wu, Y2
Zhu, P1
Jiang, Y1
Zhang, X1
Wang, Z1
Xie, B1
Song, T1
Zhang, F1
Luo, A1
Li, S1
Xiong, X1
Han, J1
Peng, X1
Li, M1
Huang, L1
Chen, Q1
Fang, W1
Hou, Y1
Zhu, Y1
Ye, J1
Liu, L1
Islam, MR1
Sanderson, P1
Johansen, MP1
Payne, TE1
Naidu, R1
Cao, J1
Yang, J1
Niu, X1
Liu, X1
Zhai, Y1
Qiang, C1
Niu, Y1
Li, Z1
Dong, N1
Wen, B1
Ouyang, Z1
Li, J2
Zhao, M1
Zhao, J1
Morici, P1
Rizzato, C1
Ghelardi, E1
Rossolini, GM1
Lupetti, A1
Gözüküçük, R1
Cakiroglu, B1
He, X1
Li, R1
Zhao, D1
Zhang, L1
Ji, X1
Fan, X1
Chen, J1
Wang, Y1
Luo, Y1
Zheng, D1
Xie, L1
Sun, S1
Cai, Z1
Liu, Q1
Ma, K1
Sun, X1
Drinkwater, JJ1
Davis, TME1
Turner, AW1
Davis, WA1
Suzuki, Y1
Mizuta, Y1
Mikagi, A1
Misawa-Suzuki, T1
Tsuchido, Y1
Sugaya, T1
Hashimoto, T1
Ema, K1
Hayashita, T1
Rao, S1
Nazarzadeh, M1
Canoy, D1
Huang, J1
Mamouei, M1
Salimi-Khorshidi, G1
Schutte, AE1
Neal, B1
Smith, GD1
Rahimi, K1
Manolis, AJ1
Kallistratos, MS1
Kabbara, WK1
Dimassi, H1
Sheikh-Taha, M1
McCrae, JC1
Morrison, EE1
MacIntyre, IM1
Dear, JW1
Webb, DJ1
Schmidt, M1
Sørensen, HT1
Pedersen, L1
Achuff, BJ1
Moffett, BS1
Acosta, S1
Lasa, JJ1
Checchia, PA1
Rusin, CG1
Fogleman, CD1
Richette, P1
Roberts, E1
Delgado Nunes, V1
Buckner, S1
Latchem, S1
Constanti, M1
Miller, P1
Doherty, M1
Zhang, W1
Birrell, F1
Porcheret, M1
Dziedzic, K1
Bernstein, I1
Wise, E1
Conaghan, PG1
Wise, J1
Roberto, G1
Simonetti, M1
Piccinni, C1
Lora Aprile, P1
Cricelli, I1
Fanelli, A1
Cricelli, C1
Lapi, F1
Bergmann, JF1
Gonzalez-Valcarcel, J1
Sissani, L1
Labreuche, J1
Bousser, MG1
Chamorro, A1
Fisher, M1
Ford, I1
Fox, KM1
Hennerici, MG1
Mattle, HP1
Rothwell, PM1
Steg, PG1
Vicaut, E1
Amarenco, P1
Hermann, M1
White, WB1
Campbell, P1
Nguyen, QV1
Roth, SH1
Anderson, S1
Hinz, B1
Brune, K1
Petersen, KU1
Lee, KC1
Palacios Jimenez, C1
Alibhai, H1
Chang, YM1
Leckie, PJ1
Baker, LA1
Stanzani, G1
L Priestnall, S1
Mookerjee, RP1
Jalan, R1
Davies, NA1
Kurth, T1
Glynn, RJ1
Walker, AM1
Rexrode, KM2
Buring, JE1
Stampfer, MJ1
Hennekens, CH1
Gaziano, JM2
Lipworth, L1
Friis, S1
Mellemkjaer, L1
Signorello, LB1
Johnsen, SP1
Nielsen, GL1
McLaughlin, JK1
Blot, WJ1
Olsen, JH1
McCormick, PA1
Treanor, D1
McCormack, G1
Farrell, M1
Kao, LW1
Kirk, MA1
Furbee, RB1
Mehta, NH1
Skinner, JR1
Brizendine, EJ1
Kean, WF1
Buchanan, WW1
Chan, AT1
Manson, JE1
Albert, CM1
Chae, CU1
Curhan, GC1
Rimm, EB1
Willett, WC1
Fuchs, CS1
Whelton, A1
Wilcox, CM1
Gibson, CM1
Schnitzer, TJ1
Johnson, J1
Weinryb, J1
Bertin, P2
Dufauret-Lombard, C1
Warren, LE1
Reinertson, R1
Camacho, ME1
Paloski, WH1
Gunn, VL1
Taha, SH1
Liebelt, EL1
Serwint, JR1
Rueff, B1
Benhamou, JP1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Oral Versus Intravenous Acetaminophen for Postoperative Pain Management After Oocyte Retrieval Procedure. A Double Blinded, Placebo Controlled, Randomized Clinical Trial[NCT04662567]42 participants (Actual)Interventional2021-03-12Terminated (stopped due to It was determined that the study should not continue as the study drug, Acetaminophen, could only be mixed in a solvent that would not allow the patients to be NPO prior to procedure.)
N-Acetylcysteine to Prevent Radiocontrast Nephropathy in Emergency Department Patients[NCT00780962]Phase 2399 participants (Actual)Interventional2007-10-16Completed
Randomized Placebo Controlled Trial of Intravenous N-Acetylcysteine for the Treatment of Acute Ischemic Stroke[NCT04918719]Phase 2118 participants (Anticipated)Interventional2021-06-01Not yet recruiting
Comparison of Supportive Therapies for Symptom Relief From Pediatric Upper Respiratory Infections (URIs)[NCT01814293]0 participants (Actual)Interventional2013-05-31Withdrawn (stopped due to loss of funding. No data was collected.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Contrast-induced Nephropathy

Contrast-induced nephropathy was defined as an increase in serum creatinine level of greater than or equal to 0.5 mg/dL or an increase of 25% above baseline. The primary outcome was measured by the change in serum creatinine level from the pre-radiocontrast baseline to the serum creatinine level measured 48 to 72 hours after radiocontrast administration. (NCT00780962)
Timeframe: 48-72 hours

InterventionParticipants (Count of Participants)
N-Acetycysteine Group14
0.9% Sodium-chloride Group12

Reviews

16 reviews available for acetaminophen and Cardiovascular Diseases

ArticleYear
Why paracetamol (acetaminophen) is a suitable first choice for treating mild to moderate acute pain in adults with liver, kidney or cardiovascular disease, gastrointestinal disorders, asthma, or who are older.
    Current medical research and opinion, 2022, Volume: 38, Issue:5

    Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics; Analgesics, Non-Narcotic; Asthma; Cardiovascular

2022
Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Hypertension.
    Hypertension (Dallas, Tex. : 1979), 2022, Volume: 79, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Ca

2022
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
    Medicina clinica (English ed.), 2022, Dec-23, Volume: 159, Issue:12

    Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter

2022
Long-term adverse effects of paracetamol - a review.
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:10

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Asthma; Cardiovascular Diseases; Chron

2018
Paracetamol: not as safe as we thought? A systematic literature review of observational studies.
    Annals of the rheumatic diseases, 2016, Volume: 75, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Cardiovascular Diseases; Dose-Response Relationship, Drug;

2016
Cardiovascular risk associated with nonsteroidal anti-inflammatory drugs.
    Current rheumatology reports, 2009, Volume: 11, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Dis

2009
The NSAID dilemma: managing osteoarthritis in high-risk patients.
    The Physician and sportsmedicine, 2011, Volume: 39, Issue:3

    Topics: Acetaminophen; Administration, Oral; Adrenal Cortex Hormones; Aged; Analgesics, Non-Narcotic; Analge

2011
Paracetamol and cyclooxygenase inhibition: is there a cause for concern?
    Annals of the rheumatic diseases, 2012, Volume: 71, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Blood Plat

2012
The use of NSAIDs in rheumatic disorders 2005: a global perspective.
    Inflammopharmacology, 2005, Volume: 13, Issue:4

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Cyclooxyge

2005
Clinical implications of nonopioid analgesia for relief of mild-to-moderate pain in patients with or at risk for cardiovascular disease.
    The American journal of cardiology, 2006, May-08, Volume: 97, Issue:9A

    Topics: Acetaminophen; Aged; Aging; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir

2006
Gastrointestinal Considerations in Patients with Cardiovascular Disease Using Nonopioid Analgesics for Mild-to-Moderate Pain or Cardioprotection.
    The American journal of cardiology, 2006, May-08, Volume: 97, Issue:9A

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Cardiovascular Diseases; Cyclooxygenase 2 Inhibito

2006
Potential for drug-drug interactions in patients taking analgesics for mild-to-moderate pain and low-dose aspirin for cardioprotection.
    The American journal of cardiology, 2006, May-08, Volume: 97, Issue:9A

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Cardiotonic Agents; Cardiovascular Diseases; Cyclo

2006
Update on guidelines for the treatment of chronic musculoskeletal pain.
    Clinical rheumatology, 2006, Volume: 25 Suppl 1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2006
Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease.
    Journal of the National Medical Association, 2006, Volume: 98, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Black or African A

2006
[What are the cardiovascular complications of the analgesics and glucocorticoids?].
    Presse medicale (Paris, France : 1983), 2006, Volume: 35, Issue:9 Spec No

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Cardiovascul

2006
Acute hepatic necrosis and fulminant hepatic failure.
    Gut, 1973, Volume: 14, Issue:10

    Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Animals; Blood Coagulation Disorders; Brain Dise

1973

Trials

2 trials available for acetaminophen and Cardiovascular Diseases

ArticleYear
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
    Medicina clinica (English ed.), 2022, Dec-23, Volume: 159, Issue:12

    Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter

2022
Implementation of the NASA Artificial Gravity Bed Rest Pilot Study.
    Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology, 2007, Volume: 14, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Bed Rest; Bone Diseases; Cardiovascular Deconditioni

2007

Other Studies

29 other studies available for acetaminophen and Cardiovascular Diseases

ArticleYear
Intrauterine and Lactational Exposure to Paracetamol: Cardiometabolic Evaluation in Adult Female and Male Offspring.
    Journal of cardiovascular pharmacology, 2021, 12-01, Volume: 78, Issue:6

    Topics: Acetaminophen; Adiposity; Analgesics, Non-Narcotic; Animals; Aorta, Thoracic; Cardiovascular Disease

2021
Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension.
    European heart journal, 2022, 05-07, Volume: 43, Issue:18

    Topics: Acetaminophen; Aged; Cardiovascular Diseases; Humans; Hypertension; Myocardial Infarction; Risk Fact

2022
Regular use of ibuprofen or paracetamol and incident type 2 diabetes: A prospective cohort study in the UK Biobank.
    Diabetes & metabolism, 2022, Volume: 48, Issue:6

    Topics: Acetaminophen; Adult; Biological Specimen Banks; Cardiovascular Diseases; Cohort Studies; Diabetes M

2022
Cardiovascular risk from sodium-containing paracetamol products.
    Drug and therapeutics bulletin, 2022, Volume: 60, Issue:12

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Cardiovascular Diseases; Heart Disease Risk Factors; Humans

2022
Sodium-based paracetamol: impact on blood pressure, cardiovascular events, and all-cause mortality.
    European heart journal, 2023, 11-07, Volume: 44, Issue:42

    Topics: Acetaminophen; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Cardiovascular Dise

2023
Deep learning approach to unmask hidden salt effects in the era of artificial intelligence.
    European heart journal, 2023, 11-07, Volume: 44, Issue:42

    Topics: Acetaminophen; Artificial Intelligence; Blood Pressure; Cardiovascular Diseases; Deep Learning; Huma

2023
Patterns of pain medication use in older individuals with cardiovascular disease.
    Current medical research and opinion, 2018, Volume: 34, Issue:5

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, No

2018
Diclofenac use and cardiovascular risks: series of nationwide cohort studies.
    BMJ (Clinical research ed.), 2018, Sep-04, Volume: 362

    Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Cohort

2018
Hypotensive Response to IV Acetaminophen in Pediatric Cardiac Patients.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2019, Volume: 20, Issue:6

    Topics: Acetaminophen; Administration, Intravenous; Age Factors; Analgesics, Non-Narcotic; Blood Pressure; C

2019
Analgesics for osteoarthritis.
    American family physician, 2013, Mar-01, Volume: 87, Issue:5

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Gastroi

2013
How safe is acetaminophen in rheumatology?
    Joint bone spine, 2014, Volume: 81, Issue:1

    Topics: Acetaminophen; Cardiovascular Diseases; Chronic Pain; Humans; Musculoskeletal Pain; Osteoarthritis;

2014
True risks of paracetamol may be underestimated, say researchers.
    BMJ (Clinical research ed.), 2015, Mar-02, Volume: 350

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Cardiovascular Diseases; Dose-Response Relationship, Drug;

2015
Risk of Acute Cerebrovascular and Cardiovascular Events Among Users of Acetaminophen or an Acetaminophen-Codeine Combination in a Cohort of Patients with Osteoarthritis: A Nested Case-Control Study.
    Pharmacotherapy, 2015, Volume: 35, Issue:10

    Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Dise

2015
[Paracetamol: do we have to reconsider the benefit/risk ratio?].
    La Revue du praticien, 2015, Volume: 65, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Cardiovascular Diseases; Humans; Risk

2015
Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke.
    Stroke, 2016, Volume: 47, Issue:4

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Brain Ischemia; Cardiovascular Diseases; Female; Hemo

2016
Blood pressure destabilization on nonsteroidal antiinflammatory agents: acetaminophen exposed?
    Circulation, 2010, Nov-02, Volume: 122, Issue:18

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cardiovascular Diseases; Dos

2010
Letter by Nguyen regarding article, "Acetaminophen increases blood pressure in patients with coronary artery disease".
    Circulation, 2011, Jun-28, Volume: 123, Issue:25

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Pressure; Cardiovascular Diseases; Coronary Artery Di

2011
[Basic drugs in pain therapy under discussion. How safe is paracetamol? (interview by Dr. Judith Neumaier)].
    MMW Fortschritte der Medizin, 2011, Dec-15, Volume: 153, Issue:51-52

    Topics: Acetaminophen; Analgesics; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Dose-Res

2011
A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival.
    Liver international : official journal of the International Association for the Study of the Liver, 2013, Volume: 33, Issue:4

    Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Animals; Biomarkers; Cardiovascular Diseases; Chemic

2013
Analgesic use and change in kidney function in apparently healthy men.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2003, Volume: 42, Issue:2

    Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovasc

2003
A population-based cohort study of mortality among adults prescribed paracetamol in Denmark.
    Journal of clinical epidemiology, 2003, Volume: 56, Issue:8

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Cardiovascular Diseases; Cause of Death; Cerebrovascu

2003
Early death from paracetamol (acetaminophen) induced fulminant hepatic failure without cerebral oedema.
    Journal of hepatology, 2003, Volume: 39, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Edema; Cardiovascular Diseases; Cause of Death

2003
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
    Annals of emergency medicine, 2003, Volume: 42, Issue:6

    Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana

2003
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
    Annals of emergency medicine, 2003, Volume: 42, Issue:6

    Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana

2003
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
    Annals of emergency medicine, 2003, Volume: 42, Issue:6

    Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana

2003
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
    Annals of emergency medicine, 2003, Volume: 42, Issue:6

    Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana

2003
Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events.
    Circulation, 2006, Mar-28, Volume: 113, Issue:12

    Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Dise

2006
Trying times for painkiller choices. Vioxx, Bextra, and Celebrex can increase the risk for heart attack and other cardiovascular problems. So can the old standbys, like ibuprofen and acetaminophen.
    Harvard heart letter : from Harvard Medical School, 2006, Volume: 17, Issue:2

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Cyclooxy

2006
[What are the cardiovascular complications of the analgesics and glucocorticoids?].
    Presse medicale (Paris, France : 1983), 2006, Volume: 35 Suppl 1

    Topics: Acetaminophen; Analgesics; Cardiovascular Diseases; Drug Prescriptions; Dyslipidemias; Glucocorticoi

2006
Etoricoxib: new drug. Avoid using cox-2 inhibitors for pain.
    Prescrire international, 2007, Volume: 16, Issue:92

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Clinical

2007
Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine.
    Acta pathologica et microbiologica Scandinavica. Section A, Pathology, 1981, Volume: 89, Issue:3

    Topics: Acetaminophen; Animals; Antipyrine; Caffeine; Cardiovascular Diseases; Heart; Male; Myocardial Infar

1981
Toxicity of over-the-counter cough and cold medications.
    Pediatrics, 2001, Volume: 108, Issue:3

    Topics: Acetaminophen; Antitussive Agents; Bradycardia; Brompheniramine; Cardiovascular Diseases; Child, Pre

2001