acetaminophen has been researched along with Cardiovascular Diseases in 46 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Excerpt | Relevance | Reference |
---|---|---|
"Acetaminophen is widely regarded as a safe therapy for pain and fever in patients with cardiovascular disease and those taking anticoagulants." | 9.22 | Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Hypertension. ( FitzGerald, GA; Grosser, T; Spence, JD, 2022) |
"The initiation of sodium-containing acetaminophen was associated with increased risks of CVD and all-cause mortality among individuals with or without hypertension." | 8.12 | Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension. ( Djousse, L; Lei, G; Li, X; Rosenberg, L; Wei, J; Zeng, C; Zhang, Y, 2022) |
" We determined whether paracetamol or ibuprofen use is associated with major cardiovascular events (MACE) or major bleeding in 19 120 patients with recent ischemic stroke or transient ischemic attack of mainly atherothrombotic origin included in the Prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) trial." | 7.83 | Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke. ( Amarenco, P; Bousser, MG; Chamorro, A; Fisher, M; Ford, I; Fox, KM; Gonzalez-Valcarcel, J; Hennerici, MG; Labreuche, J; Mattle, HP; Rothwell, PM; Sissani, L; Steg, PG; Vicaut, E, 2016) |
"To determine whether acetaminophen or an acetaminophen-codeine combination is associated with an increased risk of acute cerebrovascular and cardiovascular events (ACCEs) in patients with osteoarthritis." | 7.81 | Risk of Acute Cerebrovascular and Cardiovascular Events Among Users of Acetaminophen or an Acetaminophen-Codeine Combination in a Cohort of Patients with Osteoarthritis: A Nested Case-Control Study. ( Cricelli, C; Cricelli, I; Fanelli, A; Lapi, F; Lora Aprile, P; Piccinni, C; Roberto, G; Simonetti, M, 2015) |
" Rather, dosing for adults who are older and/or have decompensated cirrhosis, advanced kidney failure, or analgesic-induced asthma that is known to be cross-sensitive to paracetamol, should be individualized in consultation with their physician, who may recommend a lower effective dose appropriate to the circumstances." | 6.82 | Why paracetamol (acetaminophen) is a suitable first choice for treating mild to moderate acute pain in adults with liver, kidney or cardiovascular disease, gastrointestinal disorders, asthma, or who are older. ( Alchin, J; Christo, PJ; Dhar, A; Siddiqui, K, 2022) |
"Acetaminophen is widely regarded as a safe therapy for pain and fever in patients with cardiovascular disease and those taking anticoagulants." | 5.22 | Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Hypertension. ( FitzGerald, GA; Grosser, T; Spence, JD, 2022) |
"Paracetamol (acetaminophen) is the most commonly used drug in the world, with a long record of use in acute and chronic pain." | 4.98 | Long-term adverse effects of paracetamol - a review. ( Dear, JW; MacIntyre, IM; McCrae, JC; Morrison, EE; Webb, DJ, 2018) |
"Nonopioid analgesics, which include acetaminophen, aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and cyclooxygenase-2 (COX-2)-specific inhibitors (coxibs), are frequently used for the relief of mild-to-moderate pain." | 4.83 | Clinical implications of nonopioid analgesia for relief of mild-to-moderate pain in patients with or at risk for cardiovascular disease. ( Whelton, A, 2006) |
"Effervescent formulations of paracetamol containing sodium bicarbonate have been reported to associate with increased blood pressure and a higher risk of cardiovascular diseases and all-cause mortality." | 4.31 | Sodium-based paracetamol: impact on blood pressure, cardiovascular events, and all-cause mortality. ( Canoy, D; Huang, J; Li, Y; Mamouei, M; Nazarzadeh, M; Neal, B; Rahimi, K; Rao, S; Salimi-Khorshidi, G; Schutte, AE; Smith, GD, 2023) |
"The initiation of sodium-containing acetaminophen was associated with increased risks of CVD and all-cause mortality among individuals with or without hypertension." | 4.12 | Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension. ( Djousse, L; Lei, G; Li, X; Rosenberg, L; Wei, J; Zeng, C; Zhang, Y, 2022) |
" We determined whether paracetamol or ibuprofen use is associated with major cardiovascular events (MACE) or major bleeding in 19 120 patients with recent ischemic stroke or transient ischemic attack of mainly atherothrombotic origin included in the Prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) trial." | 3.83 | Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke. ( Amarenco, P; Bousser, MG; Chamorro, A; Fisher, M; Ford, I; Fox, KM; Gonzalez-Valcarcel, J; Hennerici, MG; Labreuche, J; Mattle, HP; Rothwell, PM; Sissani, L; Steg, PG; Vicaut, E, 2016) |
"To determine whether acetaminophen or an acetaminophen-codeine combination is associated with an increased risk of acute cerebrovascular and cardiovascular events (ACCEs) in patients with osteoarthritis." | 3.81 | Risk of Acute Cerebrovascular and Cardiovascular Events Among Users of Acetaminophen or an Acetaminophen-Codeine Combination in a Cohort of Patients with Osteoarthritis: A Nested Case-Control Study. ( Cricelli, C; Cricelli, I; Fanelli, A; Lapi, F; Lora Aprile, P; Piccinni, C; Roberto, G; Simonetti, M, 2015) |
" Rather, dosing for adults who are older and/or have decompensated cirrhosis, advanced kidney failure, or analgesic-induced asthma that is known to be cross-sensitive to paracetamol, should be individualized in consultation with their physician, who may recommend a lower effective dose appropriate to the circumstances." | 2.82 | Why paracetamol (acetaminophen) is a suitable first choice for treating mild to moderate acute pain in adults with liver, kidney or cardiovascular disease, gastrointestinal disorders, asthma, or who are older. ( Alchin, J; Christo, PJ; Dhar, A; Siddiqui, K, 2022) |
"We conducted a systematic literature review to assess the adverse event (AE) profile of paracetamol." | 2.53 | Paracetamol: not as safe as we thought? A systematic literature review of observational studies. ( Bernstein, I; Birrell, F; Buckner, S; Conaghan, PG; Constanti, M; Delgado Nunes, V; Doherty, M; Dziedzic, K; Latchem, S; Miller, P; Porcheret, M; Roberts, E; Wise, E; Zhang, W, 2016) |
" Because NSAIDs are associated with adverse renal effects, they should be used cautiously in patients with advanced renal disease." | 2.43 | Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease. ( Johnson, J; Weinryb, J, 2006) |
"Neuropathic pain was the most common indication (33." | 1.48 | Patterns of pain medication use in older individuals with cardiovascular disease. ( Dimassi, H; Kabbara, WK; Sheikh-Taha, M, 2018) |
"Irreversible acute liver failure, defined as rise in prothrombin time >3 times normal, occurred 19." | 1.39 | A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival. ( Alibhai, H; Baker, LA; Chang, YM; Davies, NA; Jalan, R; L Priestnall, S; Leckie, PJ; Lee, KC; Mookerjee, RP; Palacios Jimenez, C; Stanzani, G, 2013) |
" Etoricoxib is partly metabolised by the cytochrome P450 isoenzyme CYP 3A4 and increases the bioavailability of ethinylestradiol." | 1.34 | Etoricoxib: new drug. Avoid using cox-2 inhibitors for pain. ( , 2007) |
" Moreover, we observed significant dose-response relations: Compared with nonusers, the RRs for a cardiovascular event among women who used > or =15 tablets per week were 1." | 1.33 | Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events. ( Albert, CM; Chae, CU; Chan, AT; Curhan, GC; Fuchs, CS; Manson, JE; Rexrode, KM; Rimm, EB; Willett, WC, 2006) |
"We conduct a study to determine the rate of adverse events (anaphylactoid and cardiorespiratory) associated with the use of oral N-acetylcysteine by the intravenous route for the treatment of suspected acetaminophen poisoning and to examine specific variables that may be associated with adverse events." | 1.32 | What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning? ( Brizendine, EJ; Furbee, RB; Kao, LW; Kirk, MA; Mehta, NH; Skinner, JR, 2003) |
" We explore the toxicities of OTC cough and cold medications, discuss mechanisms of dosing errors, and suggest why physicians should be more vigilant in specifically inquiring about OTCs when evaluating an ill child." | 1.31 | Toxicity of over-the-counter cough and cold medications. ( Gunn, VL; Liebelt, EL; Serwint, JR; Taha, SH, 2001) |
"Four caffeine-treated rats had histologic evidence of acute myocardial infarction which was not found in any of the other rats." | 1.26 | Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine. ( Johansson, S, 1981) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (4.35) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 18 (39.13) | 29.6817 |
2010's | 17 (36.96) | 24.3611 |
2020's | 9 (19.57) | 2.80 |
Authors | Studies |
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Novi, DRBS | 1 |
Vidigal, CB | 1 |
Moura, KF | 1 |
da Silva, DG | 1 |
Serafim, AFL | 1 |
Klein, RM | 1 |
Moreira, EG | 1 |
Gerardin, DCC | 1 |
Ceravolo, GS | 1 |
Zeng, C | 1 |
Rosenberg, L | 1 |
Li, X | 1 |
Djousse, L | 1 |
Wei, J | 1 |
Lei, G | 1 |
Zhang, Y | 4 |
Alchin, J | 1 |
Dhar, A | 1 |
Siddiqui, K | 1 |
Christo, PJ | 1 |
Spence, JD | 1 |
Grosser, T | 1 |
FitzGerald, GA | 1 |
Zhou, C | 1 |
Wu, Q | 1 |
Ye, Z | 1 |
Yang, S | 1 |
Liu, M | 1 |
He, P | 1 |
Qin, X | 1 |
Qutob, HMH | 1 |
Saad, RA | 1 |
Bali, H | 1 |
Osailan, A | 1 |
Jaber, J | 1 |
Alzahrani, E | 1 |
Alyami, J | 1 |
Elsayed, H | 1 |
Alserihi, R | 1 |
Shaikhomar, OA | 1 |
Divya, KM | 1 |
Savitha, DP | 1 |
Krishna, GA | 1 |
Dhanya, TM | 1 |
Mohanan, PV | 1 |
Shah, SF | 1 |
Jafry, AT | 1 |
Hussain, G | 1 |
Kazim, AH | 1 |
Ali, M | 1 |
Rivani, E | 1 |
Endraswari, PD | 1 |
Widodo, ADW | 1 |
Khalil, MR | 1 |
Guldberg, R | 1 |
Nørgård, BM | 1 |
Uldbjerg, N | 1 |
Wehberg, S | 1 |
Fowobaje, KR | 1 |
Mashood, LO | 1 |
Ekholuenetale, M | 1 |
Ibidoja, OJ | 1 |
Romagnoli, A | 1 |
D'Agostino, M | 1 |
Pavoni, E | 1 |
Ardiccioni, C | 1 |
Motta, S | 1 |
Crippa, P | 1 |
Biagetti, G | 1 |
Notarstefano, V | 1 |
Rexha, J | 1 |
Perta, N | 1 |
Barocci, S | 1 |
Costabile, BK | 1 |
Colasurdo, G | 1 |
Caucci, S | 1 |
Mencarelli, D | 1 |
Turchetti, C | 1 |
Farina, M | 1 |
Pierantoni, L | 1 |
La Teana, A | 1 |
Al Hadi, R | 1 |
Cicconardi, F | 1 |
Chinappi, M | 1 |
Trucchi, E | 1 |
Mancia, F | 1 |
Menzo, S | 1 |
Morozzo Della Rocca, B | 1 |
D'Annessa, I | 1 |
Di Marino, D | 1 |
Choya, A | 1 |
de Rivas, B | 1 |
Gutiérrez-Ortiz, JI | 1 |
López-Fonseca, R | 1 |
Xu, S | 1 |
Cheng, B | 1 |
Huang, Z | 1 |
Liu, T | 1 |
Li, Y | 2 |
Jiang, L | 1 |
Guo, W | 1 |
Xiong, J | 1 |
Amirazodi, M | 1 |
Daryanoosh, F | 1 |
Mehrabi, A | 1 |
Gaeini, A | 1 |
Koushkie Jahromi, M | 1 |
Salesi, M | 1 |
Zarifkar, AH | 1 |
Studeny, P | 1 |
Netukova, M | 1 |
Nemcokova, M | 1 |
Klimesova, YM | 1 |
Krizova, D | 1 |
Kang, H | 1 |
Tao, Y | 1 |
Zhang, Q | 1 |
Sha, D | 1 |
Chen, Y | 1 |
Yao, J | 1 |
Gao, Y | 1 |
Liu, J | 1 |
Ji, L | 1 |
Shi, P | 1 |
Shi, C | 1 |
Wu, YL | 1 |
Wright, AI | 1 |
M El-Metwaly, N | 1 |
A Katouah, H | 1 |
El-Desouky, MG | 1 |
El-Bindary, AA | 1 |
El-Bindary, MA | 1 |
Kostakis, ID | 1 |
Raptis, DA | 1 |
Davidson, BR | 1 |
Iype, S | 1 |
Nasralla, D | 1 |
Imber, C | 1 |
Sharma, D | 1 |
Pissanou, T | 1 |
Pollok, JM | 1 |
Hughes, AM | 1 |
Sanderson, E | 1 |
Morris, T | 1 |
Ayorech, Z | 1 |
Tesli, M | 1 |
Ask, H | 1 |
Reichborn-Kjennerud, T | 1 |
Andreassen, OA | 1 |
Magnus, P | 1 |
Helgeland, Ø | 1 |
Johansson, S | 2 |
Njølstad, P | 1 |
Davey Smith, G | 1 |
Havdahl, A | 1 |
Howe, LD | 1 |
Davies, NM | 1 |
Amrillah, T | 1 |
Prasetio, A | 1 |
Supandi, AR | 1 |
Sidiq, DH | 1 |
Putra, FS | 1 |
Nugroho, MA | 1 |
Salsabilla, Z | 1 |
Azmi, R | 1 |
Grammatikopoulos, P | 1 |
Bouloumis, T | 1 |
Steinhauer, S | 1 |
Mironov, VS | 2 |
Bazhenova, TA | 2 |
Manakin, YV | 2 |
Yagubskii, EB | 2 |
Yakushev, IA | 1 |
Gilmutdinov, IF | 1 |
Simonov, SV | 1 |
Lan, K | 1 |
Yang, H | 1 |
Zheng, J | 1 |
Hu, H | 1 |
Zhu, T | 1 |
Zou, X | 1 |
Hu, B | 1 |
Liu, H | 1 |
Olokede, O | 1 |
Wu, H | 1 |
Holtzapple, M | 1 |
Gungor, O | 1 |
Kose, M | 1 |
Ghaemi, R | 1 |
Acker, M | 1 |
Stosic, A | 1 |
Jacobs, R | 1 |
Selvaganapathy, PR | 1 |
Ludwig, N | 1 |
Yerneni, SS | 1 |
Azambuja, JH | 1 |
Pietrowska, M | 1 |
Widłak, P | 1 |
Hinck, CS | 1 |
Głuszko, A | 1 |
Szczepański, MJ | 1 |
Kärmer, T | 1 |
Kallinger, I | 1 |
Schulz, D | 1 |
Bauer, RJ | 1 |
Spanier, G | 1 |
Spoerl, S | 1 |
Meier, JK | 1 |
Ettl, T | 1 |
Razzo, BM | 1 |
Reichert, TE | 1 |
Hinck, AP | 1 |
Whiteside, TL | 1 |
Wei, ZL | 1 |
Juan, W | 1 |
Tong, D | 1 |
Juan, LX | 1 |
Sa, LY | 1 |
Jie, HFM | 1 |
Xiao, G | 1 |
Xiang, LG | 1 |
Jie, HM | 1 |
Xu, C | 1 |
Yu, DN | 1 |
Yao, ZX | 1 |
Bigdeli, F | 1 |
Gao, XM | 1 |
Cheng, X | 1 |
Li, JZ | 1 |
Zhang, JW | 1 |
Wang, W | 2 |
Guan, ZJ | 1 |
Bu, Y | 1 |
Liu, KG | 1 |
Morsali, A | 1 |
Das, R | 1 |
Paul, R | 1 |
Parui, A | 1 |
Shrotri, A | 1 |
Atzori, C | 1 |
Lomachenko, KA | 1 |
Singh, AK | 1 |
Mondal, J | 1 |
Peter, SC | 1 |
Florimbio, AR | 1 |
Coughlin, LN | 1 |
Bauermeister, JA | 1 |
Young, SD | 1 |
Zimmerman, MA | 1 |
Walton, MA | 1 |
Bonar, EE | 1 |
Demir, D | 1 |
Balci, AB | 1 |
Kahraman, N | 1 |
Sunbul, SA | 1 |
Gucu, A | 1 |
Seker, IB | 1 |
Badem, S | 1 |
Yuksel, A | 1 |
Ozyazicioglu, AF | 1 |
Goncu, MT | 1 |
Zhang, H | 1 |
Zhou, H | 1 |
Deng, Z | 1 |
Luo, L | 1 |
Ong, SP | 1 |
Wang, C | 1 |
Xin, H | 1 |
Whittingham, MS | 1 |
Zhou, G | 1 |
Maemura, R | 1 |
Wakamatsu, M | 1 |
Matsumoto, K | 1 |
Sakaguchi, H | 1 |
Yoshida, N | 1 |
Hama, A | 1 |
Yoshida, T | 1 |
Miwata, S | 1 |
Kitazawa, H | 1 |
Narita, K | 1 |
Kataoka, S | 1 |
Ichikawa, D | 1 |
Hamada, M | 1 |
Taniguchi, R | 1 |
Suzuki, K | 1 |
Kawashima, N | 1 |
Nishikawa, E | 1 |
Narita, A | 1 |
Okuno, Y | 1 |
Nishio, N | 1 |
Kato, K | 1 |
Kojima, S | 1 |
Morita, K | 1 |
Muramatsu, H | 1 |
Takahashi, Y | 1 |
Yirgu, A | 1 |
Mekonnen, Y | 1 |
Eyado, A | 1 |
Staropoli, A | 1 |
Vinale, F | 1 |
Zac, J | 1 |
Zac, S | 1 |
Pérez-Padilla, R | 1 |
Remigio-Luna, A | 1 |
Guzmán-Boulloud, N | 1 |
Gochicoa-Rangel, L | 1 |
Guzmán-Valderrábano, C | 1 |
Thirión-Romero, I | 1 |
Statsenko, ME | 1 |
Turkina, SV | 1 |
Barantsevich, ER | 1 |
Karakulova, YV | 1 |
Baranova, NS | 1 |
Morzhukhina, MV | 1 |
Wang, Q | 1 |
Gu, Y | 1 |
Chen, C | 1 |
Qiao, L | 1 |
Pan, F | 1 |
Song, C | 1 |
Canetto, SS | 1 |
Entilli, L | 1 |
Cerbo, I | 1 |
Cipolletta, S | 1 |
Wu, Y | 2 |
Zhu, P | 1 |
Jiang, Y | 1 |
Zhang, X | 1 |
Wang, Z | 1 |
Xie, B | 1 |
Song, T | 1 |
Zhang, F | 1 |
Luo, A | 1 |
Li, S | 1 |
Xiong, X | 1 |
Han, J | 1 |
Peng, X | 1 |
Li, M | 1 |
Huang, L | 1 |
Chen, Q | 1 |
Fang, W | 1 |
Hou, Y | 1 |
Zhu, Y | 1 |
Ye, J | 1 |
Liu, L | 1 |
Islam, MR | 1 |
Sanderson, P | 1 |
Johansen, MP | 1 |
Payne, TE | 1 |
Naidu, R | 1 |
Cao, J | 1 |
Yang, J | 1 |
Niu, X | 1 |
Liu, X | 1 |
Zhai, Y | 1 |
Qiang, C | 1 |
Niu, Y | 1 |
Li, Z | 1 |
Dong, N | 1 |
Wen, B | 1 |
Ouyang, Z | 1 |
Li, J | 2 |
Zhao, M | 1 |
Zhao, J | 1 |
Morici, P | 1 |
Rizzato, C | 1 |
Ghelardi, E | 1 |
Rossolini, GM | 1 |
Lupetti, A | 1 |
Gözüküçük, R | 1 |
Cakiroglu, B | 1 |
He, X | 1 |
Li, R | 1 |
Zhao, D | 1 |
Zhang, L | 1 |
Ji, X | 1 |
Fan, X | 1 |
Chen, J | 1 |
Wang, Y | 1 |
Luo, Y | 1 |
Zheng, D | 1 |
Xie, L | 1 |
Sun, S | 1 |
Cai, Z | 1 |
Liu, Q | 1 |
Ma, K | 1 |
Sun, X | 1 |
Drinkwater, JJ | 1 |
Davis, TME | 1 |
Turner, AW | 1 |
Davis, WA | 1 |
Suzuki, Y | 1 |
Mizuta, Y | 1 |
Mikagi, A | 1 |
Misawa-Suzuki, T | 1 |
Tsuchido, Y | 1 |
Sugaya, T | 1 |
Hashimoto, T | 1 |
Ema, K | 1 |
Hayashita, T | 1 |
Rao, S | 1 |
Nazarzadeh, M | 1 |
Canoy, D | 1 |
Huang, J | 1 |
Mamouei, M | 1 |
Salimi-Khorshidi, G | 1 |
Schutte, AE | 1 |
Neal, B | 1 |
Smith, GD | 1 |
Rahimi, K | 1 |
Manolis, AJ | 1 |
Kallistratos, MS | 1 |
Kabbara, WK | 1 |
Dimassi, H | 1 |
Sheikh-Taha, M | 1 |
McCrae, JC | 1 |
Morrison, EE | 1 |
MacIntyre, IM | 1 |
Dear, JW | 1 |
Webb, DJ | 1 |
Schmidt, M | 1 |
Sørensen, HT | 1 |
Pedersen, L | 1 |
Achuff, BJ | 1 |
Moffett, BS | 1 |
Acosta, S | 1 |
Lasa, JJ | 1 |
Checchia, PA | 1 |
Rusin, CG | 1 |
Fogleman, CD | 1 |
Richette, P | 1 |
Roberts, E | 1 |
Delgado Nunes, V | 1 |
Buckner, S | 1 |
Latchem, S | 1 |
Constanti, M | 1 |
Miller, P | 1 |
Doherty, M | 1 |
Zhang, W | 1 |
Birrell, F | 1 |
Porcheret, M | 1 |
Dziedzic, K | 1 |
Bernstein, I | 1 |
Wise, E | 1 |
Conaghan, PG | 1 |
Wise, J | 1 |
Roberto, G | 1 |
Simonetti, M | 1 |
Piccinni, C | 1 |
Lora Aprile, P | 1 |
Cricelli, I | 1 |
Fanelli, A | 1 |
Cricelli, C | 1 |
Lapi, F | 1 |
Bergmann, JF | 1 |
Gonzalez-Valcarcel, J | 1 |
Sissani, L | 1 |
Labreuche, J | 1 |
Bousser, MG | 1 |
Chamorro, A | 1 |
Fisher, M | 1 |
Ford, I | 1 |
Fox, KM | 1 |
Hennerici, MG | 1 |
Mattle, HP | 1 |
Rothwell, PM | 1 |
Steg, PG | 1 |
Vicaut, E | 1 |
Amarenco, P | 1 |
Hermann, M | 1 |
White, WB | 1 |
Campbell, P | 1 |
Nguyen, QV | 1 |
Roth, SH | 1 |
Anderson, S | 1 |
Hinz, B | 1 |
Brune, K | 1 |
Petersen, KU | 1 |
Lee, KC | 1 |
Palacios Jimenez, C | 1 |
Alibhai, H | 1 |
Chang, YM | 1 |
Leckie, PJ | 1 |
Baker, LA | 1 |
Stanzani, G | 1 |
L Priestnall, S | 1 |
Mookerjee, RP | 1 |
Jalan, R | 1 |
Davies, NA | 1 |
Kurth, T | 1 |
Glynn, RJ | 1 |
Walker, AM | 1 |
Rexrode, KM | 2 |
Buring, JE | 1 |
Stampfer, MJ | 1 |
Hennekens, CH | 1 |
Gaziano, JM | 2 |
Lipworth, L | 1 |
Friis, S | 1 |
Mellemkjaer, L | 1 |
Signorello, LB | 1 |
Johnsen, SP | 1 |
Nielsen, GL | 1 |
McLaughlin, JK | 1 |
Blot, WJ | 1 |
Olsen, JH | 1 |
McCormick, PA | 1 |
Treanor, D | 1 |
McCormack, G | 1 |
Farrell, M | 1 |
Kao, LW | 1 |
Kirk, MA | 1 |
Furbee, RB | 1 |
Mehta, NH | 1 |
Skinner, JR | 1 |
Brizendine, EJ | 1 |
Kean, WF | 1 |
Buchanan, WW | 1 |
Chan, AT | 1 |
Manson, JE | 1 |
Albert, CM | 1 |
Chae, CU | 1 |
Curhan, GC | 1 |
Rimm, EB | 1 |
Willett, WC | 1 |
Fuchs, CS | 1 |
Whelton, A | 1 |
Wilcox, CM | 1 |
Gibson, CM | 1 |
Schnitzer, TJ | 1 |
Johnson, J | 1 |
Weinryb, J | 1 |
Bertin, P | 2 |
Dufauret-Lombard, C | 1 |
Warren, LE | 1 |
Reinertson, R | 1 |
Camacho, ME | 1 |
Paloski, WH | 1 |
Gunn, VL | 1 |
Taha, SH | 1 |
Liebelt, EL | 1 |
Serwint, JR | 1 |
Rueff, B | 1 |
Benhamou, JP | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Oral Versus Intravenous Acetaminophen for Postoperative Pain Management After Oocyte Retrieval Procedure. A Double Blinded, Placebo Controlled, Randomized Clinical Trial[NCT04662567] | 42 participants (Actual) | Interventional | 2021-03-12 | Terminated (stopped due to It was determined that the study should not continue as the study drug, Acetaminophen, could only be mixed in a solvent that would not allow the patients to be NPO prior to procedure.) | |||
N-Acetylcysteine to Prevent Radiocontrast Nephropathy in Emergency Department Patients[NCT00780962] | Phase 2 | 399 participants (Actual) | Interventional | 2007-10-16 | Completed | ||
Randomized Placebo Controlled Trial of Intravenous N-Acetylcysteine for the Treatment of Acute Ischemic Stroke[NCT04918719] | Phase 2 | 118 participants (Anticipated) | Interventional | 2021-06-01 | Not yet recruiting | ||
Comparison of Supportive Therapies for Symptom Relief From Pediatric Upper Respiratory Infections (URIs)[NCT01814293] | 0 participants (Actual) | Interventional | 2013-05-31 | Withdrawn (stopped due to loss of funding. No data was collected.) | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Contrast-induced nephropathy was defined as an increase in serum creatinine level of greater than or equal to 0.5 mg/dL or an increase of 25% above baseline. The primary outcome was measured by the change in serum creatinine level from the pre-radiocontrast baseline to the serum creatinine level measured 48 to 72 hours after radiocontrast administration. (NCT00780962)
Timeframe: 48-72 hours
Intervention | Participants (Count of Participants) |
---|---|
N-Acetycysteine Group | 14 |
0.9% Sodium-chloride Group | 12 |
16 reviews available for acetaminophen and Cardiovascular Diseases
Article | Year |
---|---|
Why paracetamol (acetaminophen) is a suitable first choice for treating mild to moderate acute pain in adults with liver, kidney or cardiovascular disease, gastrointestinal disorders, asthma, or who are older.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics; Analgesics, Non-Narcotic; Asthma; Cardiovascular | 2022 |
Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Hypertension.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Ca | 2022 |
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
Long-term adverse effects of paracetamol - a review.
Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Asthma; Cardiovascular Diseases; Chron | 2018 |
Paracetamol: not as safe as we thought? A systematic literature review of observational studies.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cardiovascular Diseases; Dose-Response Relationship, Drug; | 2016 |
Cardiovascular risk associated with nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Dis | 2009 |
The NSAID dilemma: managing osteoarthritis in high-risk patients.
Topics: Acetaminophen; Administration, Oral; Adrenal Cortex Hormones; Aged; Analgesics, Non-Narcotic; Analge | 2011 |
Paracetamol and cyclooxygenase inhibition: is there a cause for concern?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Blood Plat | 2012 |
The use of NSAIDs in rheumatic disorders 2005: a global perspective.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Cyclooxyge | 2005 |
Clinical implications of nonopioid analgesia for relief of mild-to-moderate pain in patients with or at risk for cardiovascular disease.
Topics: Acetaminophen; Aged; Aging; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir | 2006 |
Gastrointestinal Considerations in Patients with Cardiovascular Disease Using Nonopioid Analgesics for Mild-to-Moderate Pain or Cardioprotection.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Cardiovascular Diseases; Cyclooxygenase 2 Inhibito | 2006 |
Potential for drug-drug interactions in patients taking analgesics for mild-to-moderate pain and low-dose aspirin for cardioprotection.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Cardiotonic Agents; Cardiovascular Diseases; Cyclo | 2006 |
Update on guidelines for the treatment of chronic musculoskeletal pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2006 |
Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Black or African A | 2006 |
[What are the cardiovascular complications of the analgesics and glucocorticoids?].
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Cardiovascul | 2006 |
Acute hepatic necrosis and fulminant hepatic failure.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Animals; Blood Coagulation Disorders; Brain Dise | 1973 |
2 trials available for acetaminophen and Cardiovascular Diseases
Article | Year |
---|---|
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
Implementation of the NASA Artificial Gravity Bed Rest Pilot Study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Bed Rest; Bone Diseases; Cardiovascular Deconditioni | 2007 |
29 other studies available for acetaminophen and Cardiovascular Diseases
Article | Year |
---|---|
Intrauterine and Lactational Exposure to Paracetamol: Cardiometabolic Evaluation in Adult Female and Male Offspring.
Topics: Acetaminophen; Adiposity; Analgesics, Non-Narcotic; Animals; Aorta, Thoracic; Cardiovascular Disease | 2021 |
Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension.
Topics: Acetaminophen; Aged; Cardiovascular Diseases; Humans; Hypertension; Myocardial Infarction; Risk Fact | 2022 |
Regular use of ibuprofen or paracetamol and incident type 2 diabetes: A prospective cohort study in the UK Biobank.
Topics: Acetaminophen; Adult; Biological Specimen Banks; Cardiovascular Diseases; Cohort Studies; Diabetes M | 2022 |
Cardiovascular risk from sodium-containing paracetamol products.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cardiovascular Diseases; Heart Disease Risk Factors; Humans | 2022 |
Sodium-based paracetamol: impact on blood pressure, cardiovascular events, and all-cause mortality.
Topics: Acetaminophen; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Cardiovascular Dise | 2023 |
Deep learning approach to unmask hidden salt effects in the era of artificial intelligence.
Topics: Acetaminophen; Artificial Intelligence; Blood Pressure; Cardiovascular Diseases; Deep Learning; Huma | 2023 |
Patterns of pain medication use in older individuals with cardiovascular disease.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, No | 2018 |
Diclofenac use and cardiovascular risks: series of nationwide cohort studies.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Cohort | 2018 |
Hypotensive Response to IV Acetaminophen in Pediatric Cardiac Patients.
Topics: Acetaminophen; Administration, Intravenous; Age Factors; Analgesics, Non-Narcotic; Blood Pressure; C | 2019 |
Analgesics for osteoarthritis.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Gastroi | 2013 |
How safe is acetaminophen in rheumatology?
Topics: Acetaminophen; Cardiovascular Diseases; Chronic Pain; Humans; Musculoskeletal Pain; Osteoarthritis; | 2014 |
True risks of paracetamol may be underestimated, say researchers.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cardiovascular Diseases; Dose-Response Relationship, Drug; | 2015 |
Risk of Acute Cerebrovascular and Cardiovascular Events Among Users of Acetaminophen or an Acetaminophen-Codeine Combination in a Cohort of Patients with Osteoarthritis: A Nested Case-Control Study.
Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Dise | 2015 |
[Paracetamol: do we have to reconsider the benefit/risk ratio?].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cardiovascular Diseases; Humans; Risk | 2015 |
Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Brain Ischemia; Cardiovascular Diseases; Female; Hemo | 2016 |
Blood pressure destabilization on nonsteroidal antiinflammatory agents: acetaminophen exposed?
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cardiovascular Diseases; Dos | 2010 |
Letter by Nguyen regarding article, "Acetaminophen increases blood pressure in patients with coronary artery disease".
Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Pressure; Cardiovascular Diseases; Coronary Artery Di | 2011 |
[Basic drugs in pain therapy under discussion. How safe is paracetamol? (interview by Dr. Judith Neumaier)].
Topics: Acetaminophen; Analgesics; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Dose-Res | 2011 |
A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Animals; Biomarkers; Cardiovascular Diseases; Chemic | 2013 |
Analgesic use and change in kidney function in apparently healthy men.
Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovasc | 2003 |
A population-based cohort study of mortality among adults prescribed paracetamol in Denmark.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Cardiovascular Diseases; Cause of Death; Cerebrovascu | 2003 |
Early death from paracetamol (acetaminophen) induced fulminant hepatic failure without cerebral oedema.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Edema; Cardiovascular Diseases; Cause of Death | 2003 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana | 2003 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana | 2003 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana | 2003 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana | 2003 |
Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events.
Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Dise | 2006 |
Trying times for painkiller choices. Vioxx, Bextra, and Celebrex can increase the risk for heart attack and other cardiovascular problems. So can the old standbys, like ibuprofen and acetaminophen.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Cyclooxy | 2006 |
[What are the cardiovascular complications of the analgesics and glucocorticoids?].
Topics: Acetaminophen; Analgesics; Cardiovascular Diseases; Drug Prescriptions; Dyslipidemias; Glucocorticoi | 2006 |
Etoricoxib: new drug. Avoid using cox-2 inhibitors for pain.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Clinical | 2007 |
Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine.
Topics: Acetaminophen; Animals; Antipyrine; Caffeine; Cardiovascular Diseases; Heart; Male; Myocardial Infar | 1981 |
Toxicity of over-the-counter cough and cold medications.
Topics: Acetaminophen; Antitussive Agents; Bradycardia; Brompheniramine; Cardiovascular Diseases; Child, Pre | 2001 |