Page last updated: 2024-10-22

acetaminophen and Cardiac Failure

acetaminophen has been researched along with Cardiac Failure in 11 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

ExcerptRelevanceReference
"Acetaminophen poisoning increases cytochrome P450 2E1 expression and reactive oxygen species production, which may lead to maladaptive myocardial remodeling and congestive heart failure (CHF)."7.88Increased risk of congestive heart failure in patients with acetaminophen poisoning: A nationwide cohort study. ( Chung, WS; Lin, CL, 2018)
"Toxic myocarditis is an extremely rare complication of acetaminophen overdose."5.46Toxic Myocarditis Caused by Acetaminophen in a Multidrug Overdose. ( Crahes, M; Dazé, Y; Gosselin, M; Mireault, P, 2017)
"Acetaminophen poisoning increases cytochrome P450 2E1 expression and reactive oxygen species production, which may lead to maladaptive myocardial remodeling and congestive heart failure (CHF)."3.88Increased risk of congestive heart failure in patients with acetaminophen poisoning: A nationwide cohort study. ( Chung, WS; Lin, CL, 2018)
" There was no lysozymuria with severe uraemic heart failure, aspirin and paracetamol poisoning, or severe jaundice, nor in two cases of acute glomerulonephritis."3.65Lysozymuria and acute disorders of renal function. ( De Silva, KL; Harrison, JF; Parker, RW, 1973)
"Toxic myocarditis is an extremely rare complication of acetaminophen overdose."1.46Toxic Myocarditis Caused by Acetaminophen in a Multidrug Overdose. ( Crahes, M; Dazé, Y; Gosselin, M; Mireault, P, 2017)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19903 (27.27)18.7374
1990's1 (9.09)18.2507
2000's2 (18.18)29.6817
2010's4 (36.36)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Perrin, G1
Arnoux, A1
Berdot, S1
Katsahian, S1
Danchin, N1
Sabatier, B1
Gosselin, M1
Dazé, Y1
Mireault, P1
Crahes, M1
Chung, WS1
Lin, CL1
Manakkat Vijay, GK1
Kronsten, VT1
Bain, BJ1
Shawcross, DL1
Lipworth, L1
Abdel-Kader, K1
Morse, J1
Stewart, TG1
Kabagambe, EK1
Parr, SK1
Birdwell, KA1
Matheny, ME1
Hung, AM1
Blot, WJ1
Ikizler, TA1
Siew, ED1
Francis, GS1
Bennett, RM1
Schein, J1
Kosinski, MR1
Hewitt, DJ1
Jordan, DM1
Rosenthal, NR1
Bonkovsky, HL1
Kane, RE1
Jones, DP1
Galinsky, RE1
Banner, B1
Ohtani, N1
Matsuzaki, M1
Anno, Y1
Ogawa, H1
Matsuda, Y1
Kusukawa, R1
Kumar, NP1
Sethuraman, KR1
Chandrasekar, S1
Ray, K1
Adithan, C1
Shashindran, CH1
Harrison, JF1
Parker, RW1
De Silva, KL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Study of Losartan to Reduce Radiation Induced Fibrosis in Breast Cancer Patients[NCT05637216]Phase 240 participants (Anticipated)Interventional2023-08-17Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for acetaminophen and Cardiac Failure

ArticleYear
Impact of fibromyalgia pain on health-related quality of life before and after treatment with tramadol/acetaminophen.
    Arthritis and rheumatism, 2005, Aug-15, Volume: 53, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind M

2005

Other Studies

10 other studies available for acetaminophen and Cardiac Failure

ArticleYear
Association Between Exposure to Effervescent Paracetamol and Hospitalization for Acute Heart Failure: A Case-Crossover Study.
    Journal of clinical pharmacology, 2022, Volume: 62, Issue:7

    Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged, 80 and over; Cross-Over Studies; Heart Failur

2022
Toxic Myocarditis Caused by Acetaminophen in a Multidrug Overdose.
    The American journal of forensic medicine and pathology, 2017, Volume: 38, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antips

2017
Increased risk of congestive heart failure in patients with acetaminophen poisoning: A nationwide cohort study.
    Journal of applied toxicology : JAT, 2018, Volume: 38, Issue:5

    Topics: Acetaminophen; Adult; Age Factors; Case-Control Studies; Cohort Studies; Female; Heart Failure; Huma

2018
Neutrophil vacuolation in acetaminophen-induced acute liver failure.
    American journal of hematology, 2015, Volume: 90, Issue:5

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Female; Granulocyte Colony-Stimulating Factor;

2015
High prevalence of non-steroidal anti-inflammatory drug use among acute kidney injury survivors in the southern community cohort study.
    BMC nephrology, 2016, 11-24, Volume: 17, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroida

2016
I have arthritis and take ibuprofen. Can ibuprofen cause heart failure?
    Heart advisor, 2002, Volume: 5, Issue:10

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Heart Failure; Humans; Ibuprofen

2002
Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency.
    Hepatology (Baltimore, Md.), 1994, Volume: 19, Issue:5

    Topics: Acetaminophen; Aged; Alcoholism; Chronic Disease; Glutathione; Heart Failure; Humans; Kidney; Liver;

1994
A case of myocardial damage following acute paracetamol poisoning.
    Japanese circulation journal, 1989, Volume: 53, Issue:3

    Topics: Acetaminophen; Acute Disease; Adult; Cardiomegaly; Echocardiography; Electrocardiography; Female; He

1989
Salivary paracetamol elimination in patients with congestive cardiac failure.
    Clinical and experimental pharmacology & physiology, 1987, Volume: 14, Issue:9

    Topics: Acetaminophen; Adult; Half-Life; Heart Failure; Humans; Male; Saliva

1987
Lysozymuria and acute disorders of renal function.
    Journal of clinical pathology, 1973, Volume: 26, Issue:4

    Topics: Acetaminophen; Acute Disease; Aspirin; Electroshock; Glomerulonephritis; Heart Failure; Humans; Hypo

1973