acetaminophen has been researched along with Cancer of Liver in 68 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We conducted a phase I trial of high dose paracetamol and carmustine (BCNU) in patients with advanced malignant melanoma to determine the optimal biological dose and the maximum tolerated dose (MTD) with the goal of increasing sensitivity to BCNU by GSH depletion." | 9.10 | Phase I trial of high dose paracetamol and carmustine in patients with metastatic melanoma. ( Chang, C; Chapman, PB; Fleisher, M; Hwu, WJ; Krown, SE; Livingston, PO; Pinto, JT; Williams, L; Wolchok, JD, 2003) |
| " The objective of this study was to investigate whether acetaminophen (AAP) can enhance cisplatin (CDDP) cytotoxicity against human hepatocarcinoma and hepatoblastoma cells in vitro and whether this effect can be prevented by N-acetylcysteine (NAC)." | 7.75 | Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines. ( Czauderna, P; Fuchs, J; Knap, N; Losin, M; Neuwelt, AJ; Neuwelt, EA; Pagel, MA; Warmann, S; Wozniak, M; Wu, YJ, 2009) |
| " Our patient presented with intentional acetaminophen overdose, received a transplant from a brain dead donor, and was confirmed brain dead 12 days posttransplant." | 5.12 | A Liver's Iliad: Liver Graft Retransplant to a Second Recipient After Brain Death in a First Recipient. ( Boira, MA; Ferreira, L; Maguire, D; Nair, S; Stafford, A, 2021) |
| "Phenacetin pharmacokinetics and the recovery of its urinary metabolites were studied in 8 normal subjects, 16 patients with chronic hepatitis B and 12 patients with cirrhosis." | 5.12 | Impaired clearance of phenacetin in hepatic cirrhosis and fibrosis. ( He, P; Li, XD; Liu, HL; Qu, ZQ; Wu, MC; Zhang, X, 2007) |
| " We conducted a phase I trial of high dose paracetamol and carmustine (BCNU) in patients with advanced malignant melanoma to determine the optimal biological dose and the maximum tolerated dose (MTD) with the goal of increasing sensitivity to BCNU by GSH depletion." | 5.10 | Phase I trial of high dose paracetamol and carmustine in patients with metastatic melanoma. ( Chang, C; Chapman, PB; Fleisher, M; Hwu, WJ; Krown, SE; Livingston, PO; Pinto, JT; Williams, L; Wolchok, JD, 2003) |
| " This review summarises the evidence for potential therapeutic applications of non-immunosuppressive cyclophilin inhibitors, alone or in combination with other agents, in virus-induced liver diseases like hepatitis C, B or Delta, liver inflammation and fibrosis, acetaminophen-induced liver toxicity and hepatocellular carcinoma." | 4.90 | Cyclophilin inhibition as potential therapy for liver diseases. ( Naoumov, NV, 2014) |
| " The objective of this study was to investigate whether acetaminophen (AAP) can enhance cisplatin (CDDP) cytotoxicity against human hepatocarcinoma and hepatoblastoma cells in vitro and whether this effect can be prevented by N-acetylcysteine (NAC)." | 3.75 | Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines. ( Czauderna, P; Fuchs, J; Knap, N; Losin, M; Neuwelt, AJ; Neuwelt, EA; Pagel, MA; Warmann, S; Wozniak, M; Wu, YJ, 2009) |
| "The acetaminophen test was performed on 12 normal subjects and 26 HCC patients." | 2.75 | The effect of transcatheter arterial chemoembolization on phase II drug metabolism enzymes in patients with hepatocellular carcinoma. ( Jia, Y; Liu, L; Liu, X; Wang, Q; Wen, A; Zhang, Y, 2010) |
| " Studies of the relationship between genotoxicity and toxic effects in the rat (induction of micronuclei in rat bone marrow including dose-response relationship, biotransformation of paracetamol at different dosages, concomitant toxicity and biochemical markers) have recently been completed." | 2.39 | Series: current issues in mutagenesis and carcinogenesis, No. 65. The genotoxicity and carcinogenicity of paracetamol: a regulatory (re)view. ( Bergman, K; Müller, L; Teigen, SW, 1996) |
| " baseline glutathione (GSH) levels, pharmacokinetics, and capacity of hepatic antioxidants) leads to potential differences in carcinogenic hazard potential at different dosing schemes: maximum labeled doses of 4 g/day, repeated doses above the maximum labeled dose (>4-12 g/day), and acute overdoses of acetaminophen (>15 g)." | 1.56 | Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen. ( Atillasoy, E; Eichenbaum, G; Gebremichael, Y; Gelotte, CK; Howell, BA; Jacobson-Kram, D; Jaeschke, H; Kuffner, E; Lai, JCK; Murray, FJ; Wikoff, D; Yang, K, 2020) |
| "HepaRG is a proliferative human hepatoma-derived cell line that can be differentiated into hepatocyte-like and biliary-like cells." | 1.51 | Comparison of HepaRG cells following growth in proliferative and differentiated culture conditions reveals distinct bioenergetic profiles. ( Young, CKJ; Young, MJ, 2019) |
| "Recently, we discovered that the hepatocellular carcinoma reporter (HCR) mice previously generated in our laboratory also expressed luciferase in the spermatids of the testis." | 1.48 | A new bioluminescent imaging technology for studying oxidative stress in the testis and its impacts on fertility. ( Feng, Y; Hu, X; Li, P; Lou, H; Luo, G; Ma, Q; Ma, Z; Shao, H; Zeng, X; Zhang, L, 2018) |
| " Despite being safe at therapeutic doses, an accidental or intentional overdose can result in severe hepatotoxicity; a leading cause of drug-induced liver failure in the U." | 1.42 | Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells. ( Ercal, N; Fan, W; Khayyat, A; Tobwala, S, 2015) |
| "In the present study, using human hepatoma HepG2 cells, we have further demonstrated that macrophages are a more sensitive target for APAP-induced toxicity than HepG2 cells." | 1.42 | Differential Cytotoxicity of Acetaminophen in Mouse Macrophage J774.2 and Human Hepatoma HepG2 Cells: Protection by Diallyl Sulfide. ( John, A; Raza, H, 2015) |
| " Toxicity studies with Diclofenac, Paracetamol and Verapamil in both cell lines show dose-response characteristics and EC(50) values similar to hHeps." | 1.38 | Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism. ( Dooley, S; Ehnert, S; Hao, L; Lin, J; Liu, L; Mühl-Benninghaus, R; Neumann, J; Nussler, AK; Nussler, N; Schyschka, L; Stöckle, U, 2012) |
| "The phenacetin test was performed in 56 normal subjects and 92 HCC patients." | 1.35 | The effect of transcatheter arterial chemoembolization on CYP1A2 activity in patients with hepatocellular carcinoma. ( Ding, N; He, P; Huang, W; Li, XD; Qu, ZQ; Wu, MC; Zhang, SL, 2008) |
| "Acetaminophen was given in the diet either alone at 2400 or 4800 p." | 1.34 | Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene. ( Duan, JD; Iatropoulos, MJ; Jeffrey, AM; Perrone, CE; Williams, GM, 2007) |
| "The new human hepatoma cell line HBG BC2 possesses the capacity of being reversibly differentiated in vitro and of maintaining a relatively higher metabolic rate when in the differentiated state (3 weeks) as compared to HepG2 cells, and thus may allow the conduct of repeated toxicity testing on cells in culture." | 1.32 | A new hepatoma cell line for toxicity testing at repeated doses. ( Arrivet, E; Bichet, N; Fabre, N; Prenez, A; Roome, NO; Trancard, J; Vericat, JA, 2003) |
| "Acetaminophen treatment of HepG2 cells caused oxidative damage and apoptosis." | 1.32 | N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis. ( Hirsh, M; Iancu, TC; Manov, I, 2004) |
| ") dosing of 600mg AAP 3h before AFB(1) i." | 1.31 | Differential effects of acetaminophen pretreatment on hepatic aflatoxin B(1)-DNA binding, cellular proliferation, and aflatoxin B1-induced hepatic foci in rats and hamsters. ( Gaughan, JP; Gopalan-Kriczky, P; Hiruma, S; Lotlikar, PD; Qin, G, 2001) |
| "The human hepatoma cell line, HepG2, retains many cellular functions often lost by cells in culture." | 1.29 | HepG2 cells: an in vitro model for P450-dependent metabolism of acetaminophen. ( Benson, RW; Casciano, DA; Roberts, DW; Roe, AL; Snawder, JE, 1993) |
| "(3) A human hepatoma cell line (Hep G2) was studied to obtain information on the inducibility of human UDP-GT activities by 3-methylcholanthrene-type inducers." | 1.27 | Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers. ( Bock, KW; Bock-Hennig, BS, 1987) |
| "Cells from a rat hepatoma grown in culture were found to activate methyldopa to intermediates which are bound irreversibly to cellular proteins." | 1.26 | Methyldopa binding to cells in culture. ( Dybing, E, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (23.53) | 18.7374 |
| 1990's | 6 (8.82) | 18.2507 |
| 2000's | 21 (30.88) | 29.6817 |
| 2010's | 21 (30.88) | 24.3611 |
| 2020's | 4 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Qutob, HMH | 1 |
| Saad, RA | 1 |
| Bali, H | 1 |
| Osailan, A | 1 |
| Jaber, J | 1 |
| Alzahrani, E | 1 |
| Alyami, J | 1 |
| Elsayed, H | 1 |
| Alserihi, R | 1 |
| Shaikhomar, OA | 1 |
| Divya, KM | 1 |
| Savitha, DP | 1 |
| Krishna, GA | 1 |
| Dhanya, TM | 1 |
| Mohanan, PV | 1 |
| Shah, SF | 1 |
| Jafry, AT | 1 |
| Hussain, G | 1 |
| Kazim, AH | 1 |
| Ali, M | 1 |
| Rivani, E | 1 |
| Endraswari, PD | 1 |
| Widodo, ADW | 1 |
| Khalil, MR | 1 |
| Guldberg, R | 1 |
| Nørgård, BM | 1 |
| Uldbjerg, N | 1 |
| Wehberg, S | 1 |
| Fowobaje, KR | 1 |
| Mashood, LO | 1 |
| Ekholuenetale, M | 1 |
| Ibidoja, OJ | 1 |
| Romagnoli, A | 1 |
| D'Agostino, M | 1 |
| Pavoni, E | 1 |
| Ardiccioni, C | 1 |
| Motta, S | 1 |
| Crippa, P | 1 |
| Biagetti, G | 1 |
| Notarstefano, V | 1 |
| Rexha, J | 1 |
| Perta, N | 1 |
| Barocci, S | 1 |
| Costabile, BK | 1 |
| Colasurdo, G | 1 |
| Caucci, S | 1 |
| Mencarelli, D | 1 |
| Turchetti, C | 1 |
| Farina, M | 1 |
| Pierantoni, L | 1 |
| La Teana, A | 1 |
| Al Hadi, R | 1 |
| Cicconardi, F | 1 |
| Chinappi, M | 1 |
| Trucchi, E | 1 |
| Mancia, F | 1 |
| Menzo, S | 1 |
| Morozzo Della Rocca, B | 1 |
| D'Annessa, I | 1 |
| Di Marino, D | 1 |
| Choya, A | 1 |
| de Rivas, B | 1 |
| Gutiérrez-Ortiz, JI | 1 |
| López-Fonseca, R | 1 |
| Xu, S | 1 |
| Cheng, B | 1 |
| Huang, Z | 1 |
| Liu, T | 1 |
| Li, Y | 1 |
| Jiang, L | 1 |
| Guo, W | 1 |
| Xiong, J | 1 |
| Amirazodi, M | 1 |
| Daryanoosh, F | 1 |
| Mehrabi, A | 1 |
| Gaeini, A | 1 |
| Koushkie Jahromi, M | 1 |
| Salesi, M | 1 |
| Zarifkar, AH | 1 |
| Studeny, P | 1 |
| Netukova, M | 1 |
| Nemcokova, M | 1 |
| Klimesova, YM | 1 |
| Krizova, D | 1 |
| Kang, H | 1 |
| Tao, Y | 1 |
| Zhang, Q | 1 |
| Sha, D | 1 |
| Chen, Y | 1 |
| Yao, J | 1 |
| Gao, Y | 1 |
| Liu, J | 1 |
| Ji, L | 1 |
| Shi, P | 1 |
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| Wu, YL | 1 |
| Wright, AI | 1 |
| M El-Metwaly, N | 1 |
| A Katouah, H | 1 |
| El-Desouky, MG | 1 |
| El-Bindary, AA | 1 |
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| Kostakis, ID | 1 |
| Raptis, DA | 1 |
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| Pollok, JM | 1 |
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| Sanderson, E | 1 |
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| Grammatikopoulos, P | 1 |
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| Mironov, VS | 2 |
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| Yakushev, IA | 1 |
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| Deng, Z | 1 |
| Luo, L | 1 |
| Ong, SP | 1 |
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| Whittingham, MS | 1 |
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| Maemura, R | 1 |
| Wakamatsu, M | 1 |
| Matsumoto, K | 1 |
| Sakaguchi, H | 1 |
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| Yoshida, T | 1 |
| Miwata, S | 1 |
| Kitazawa, H | 1 |
| Narita, K | 1 |
| Kataoka, S | 1 |
| Ichikawa, D | 1 |
| Hamada, M | 1 |
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| Suzuki, K | 1 |
| Kawashima, N | 1 |
| Nishikawa, E | 1 |
| Narita, A | 1 |
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| Nishio, N | 1 |
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| Takahashi, Y | 1 |
| Yirgu, A | 1 |
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| Statsenko, ME | 1 |
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| Barantsevich, ER | 1 |
| Karakulova, YV | 1 |
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| Urushidani, T | 1 |
| Tobwala, S | 1 |
| Khayyat, A | 1 |
| Fan, W | 1 |
| Ercal, N | 1 |
| Santacatterina, F | 1 |
| Sánchez-Cenizo, L | 1 |
| Formentini, L | 1 |
| Mobasher, MA | 1 |
| Casas, E | 1 |
| Rueda, CB | 1 |
| Martínez-Reyes, I | 1 |
| Núñez de Arenas, C | 1 |
| García-Bermúdez, J | 1 |
| Zapata, JM | 1 |
| Sánchez-Aragó, M | 1 |
| Satrústegui, J | 1 |
| Valverde, ÁM | 1 |
| Cuezva, JM | 1 |
| Raza, H | 1 |
| John, A | 1 |
| Yang, B | 1 |
| Petrick, JL | 1 |
| Hagberg, KW | 1 |
| Sahasrabuddhe, VV | 1 |
| Graubard, BI | 1 |
| Jick, S | 1 |
| McGlynn, KA | 1 |
| Copple, IM | 1 |
| Goldring, CE | 1 |
| Jenkins, RE | 1 |
| Chia, AJ | 1 |
| Randle, LE | 1 |
| Hayes, JD | 1 |
| Kitteringham, NR | 1 |
| Park, BK | 1 |
| Hwang, HJ | 1 |
| Kim, IH | 1 |
| Nam, TJ | 1 |
| Huang, W | 2 |
| Qu, ZQ | 3 |
| Li, XD | 3 |
| He, P | 3 |
| Ding, N | 1 |
| Zhang, SL | 1 |
| Wu, MC | 3 |
| Jia, Y | 1 |
| Wen, A | 1 |
| Neuwelt, AJ | 1 |
| Wu, YJ | 1 |
| Knap, N | 1 |
| Losin, M | 1 |
| Neuwelt, EA | 1 |
| Pagel, MA | 1 |
| Warmann, S | 1 |
| Fuchs, J | 1 |
| Czauderna, P | 1 |
| Wozniak, M | 1 |
| Wang, XR | 1 |
| Liu, HL | 2 |
| Fang, BX | 1 |
| Xiao, J | 1 |
| Jih, JS | 1 |
| Chen, YJ | 1 |
| Lin, MW | 1 |
| Chen, YC | 1 |
| Chen, TJ | 1 |
| Huang, YL | 1 |
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10 reviews available for acetaminophen and Cancer of Liver
| Article | Year |
|---|---|
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
A Liver's Iliad: Liver Graft Retransplant to a Second Recipient After Brain Death in a First Recipient.
Topics: Acetaminophen; Brain Death; Fibrosis; Graft Survival; Humans; Liver Cirrhosis; Liver Neoplasms; Live | 2021 |
Cyclophilin inhibition as potential therapy for liver diseases.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Cyclophil | 2014 |
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Carcinoma, Hepatocellular; Cell Death; | 2012 |
Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Ster | 2006 |
Role of Kupffer cells in host defense and liver disease.
Topics: Acetaminophen; Animals; Cell Communication; Fatty Liver; Hemoglobins; Humans; Immune Tolerance; Immu | 2006 |
Hepatotoxicity: newer aspects of pathogenesis and treatment.
Topics: Acetaminophen; Acetylcysteine; Adenoma, Liver Cell; Adult; Amoxicillin; Anabolic Agents; Beverages; | 1995 |
Series: current issues in mutagenesis and carcinogenesis, No. 65. The genotoxicity and carcinogenicity of paracetamol: a regulatory (re)view.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bacteria; Biotransformation; Carcinogens; Cell Lin | 1996 |
Drug metabolism in the production of liver injury.
Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injur | 1975 |
The influence of diet on activation and inactivation of chemicals--evidence from animals and man.
Topics: 1,2-Dimethylhydrazine; Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Co | 1986 |
5 trials available for acetaminophen and Cancer of Liver
| Article | Year |
|---|---|
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
The effect of transcatheter arterial chemoembolization on phase II drug metabolism enzymes in patients with hepatocellular carcinoma.
Topics: Acetaminophen; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Female; Glucuronosyltransf | 2010 |
Postoperative pain relief after hepatic resection in cirrhotic patients: the efficacy of a single small dose of ketamine plus morphine epidurally.
Topics: Acetaminophen; Adult; Aged; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthetics, Dissoc | 2003 |
Phase I trial of high dose paracetamol and carmustine in patients with metastatic melanoma.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antineoplastic Agents, Alkylating; Carmusti | 2003 |
Impaired clearance of phenacetin in hepatic cirrhosis and fibrosis.
Topics: Acetaminophen; Area Under Curve; Biotransformation; Carcinoma, Hepatocellular; Chemoembolization, Th | 2007 |
54 other studies available for acetaminophen and Cancer of Liver
| Article | Year |
|---|---|
Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells.
Topics: Acetaminophen; Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver | 2023 |
Paracetamol-Galactose Conjugate: A Novel Prodrug for an Old Analgesic Drug.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Gal | 2019 |
Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Carcinogenicity Tests; Cell Death; Chemical a | 2020 |
Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury.
Topics: Acetaminophen; Acute Lung Injury; Animals; Autophagy; Carbon Tetrachloride; Carcinoma, Hepatocellula | 2017 |
A new bioluminescent imaging technology for studying oxidative stress in the testis and its impacts on fertility.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carcinoma, Hepatocellular; Disease Models, Animal; | 2018 |
Eight new glycosides with hepatoprotective activity isolated from the aerial parts of Morinda parvifolia.
Topics: Acetaminophen; Animals; Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; Drug Sc | 2019 |
Comparison of HepaRG cells following growth in proliferative and differentiated culture conditions reveals distinct bioenergetic profiles.
Topics: Acetaminophen; Adenosine Triphosphate; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Diff | 2019 |
Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; DNA D | 2014 |
Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Carcinoma, Hepatocellular; Cell | 2015 |
Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Apoptosis; ATPase Inhibitory Protein; Blottin | 2016 |
Differential Cytotoxicity of Acetaminophen in Mouse Macrophage J774.2 and Human Hepatoma HepG2 Cells: Protection by Diallyl Sulfide.
Topics: Acetaminophen; Adenosine Triphosphate; Allyl Compounds; Apoptosis; Carcinoma, Hepatocellular; Cell R | 2015 |
Associations of NSAID and paracetamol use with risk of primary liver cancer in the Clinical Practice Research Datalink.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Humans; Liver Neoplasm | 2016 |
The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system.
Topics: Acetaminophen; Adaptor Proteins, Signal Transducing; Animals; Benzoquinones; Carcinoma, Hepatocellul | 2008 |
Effect of a glycoprotein from Hizikia fusiformis on acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Caspase 3; Caspase 9; | 2008 |
The effect of transcatheter arterial chemoembolization on CYP1A2 activity in patients with hepatocellular carcinoma.
Topics: Acetaminophen; Adult; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cytochrome P-450 CY | 2008 |
Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents; Blotting, W | 2009 |
Activity of sulfotransferase 1A1 is dramatically upregulated in patients with hepatocellular carcinoma secondary to chronic hepatitis B virus infection.
Topics: Acetaminophen; Adult; Aged; Arylsulfotransferase; Carcinoma, Hepatocellular; Cytochrome P-450 CYP1A2 | 2010 |
Epidemiological features and costs of herpes zoster in Taiwan: a national study 2000 to 2006.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; An | 2009 |
Cancer/testis antigens and clinical risk factors for liver metastasis of colorectal cancer: a predictive panel.
Topics: Acetaminophen; Adult; Aged, 80 and over; Antigens, Neoplasm; Biomarkers, Tumor; Colorectal Neoplasms | 2010 |
Validation of reference gene stability for APAP hepatotoxicity studies in different in vitro systems and identification of novel potential toxicity biomarkers.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers, Pharmacological; Carcinoma, Hepatocell | 2010 |
Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism.
Topics: Acetaminophen; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Cytochrome P-450 Enzyme | 2012 |
Liver tumours, toxic hepatitis, intestinal failure-associated liver disease in children.
Topics: Acetaminophen; Amoxicillin-Potassium Clavulanate Combination; Analgesics, Non-Narcotic; Anti-Bacteri | 2012 |
ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis.
Topics: Acetaminophen; Animals; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Disease Models, An | 2013 |
Pharmacogenetic selection of transplanted human hepatocytes in immunocompetent rats.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Carcinoma, Hepatocellular; C | 2012 |
Notch2 signaling and undifferentiated liver cancers: evidence of hepatic stem/progenitor cell origin.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diethylni | 2013 |
A new hepatoma cell line for toxicity testing at repeated doses.
Topics: Acetaminophen; Aspirin; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Dru | 2003 |
Mangafodipir prevents liver injury induced by acetaminophen in the mouse.
Topics: Acetaminophen; Animals; Antibodies, Monoclonal; Antioxidants; Carcinoma, Hepatocellular; Caspase 3; | 2003 |
The role of apoptosis in acetaminophen-induced injury.
Topics: Acetaminophen; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Humans; Liver; | 2003 |
N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis.
Topics: Acetaminophen; Acetylcysteine; Antioxidants; Apoptosis; Calcium; Cations, Divalent; Cell Line, Tumor | 2004 |
Successful treatment of doxorubicin and cisplatin resistant hepatoblastoma in a child with Beckwith-Wiedemann syndrome with high dose acetaminophen and N-acetylcysteine rescue.
Topics: Acetaminophen; Acetylcysteine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols | 2005 |
Comments on "glycogen synthase kinase-3 mediates acetaminophen-induced apoptosis in human hepatoma cells".
Topics: Acetaminophen; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; fas Receptor; Glycogen Syntha | 2005 |
In vitro system for the prediction of hepatotoxic effects in primary hepatocytes.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animal Testing Alternatives; Animals; Carcinoma, Hepatocell | 2007 |
Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene.
Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Antineoplastic Agents; Body Weight; Carcinoma, Hepato | 2007 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |
Modifying effects of butylated hydroxyanisole, ethoxyquin and acetaminophen on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine.
Topics: Acetaminophen; Adenocarcinoma; Animals; Anisoles; Butylated Hydroxyanisole; Carcinogens; Diethylnitr | 1984 |
Modification of carcinogenesis by antioxidants and other compounds.
Topics: Acetaminophen; Animals; Antioxidants; Body Weight; Butylated Hydroxyanisole; Carcinogens; Diethylnit | 1984 |
A methodology for the analysis of the preneoplastic antigen.
Topics: Acetaminophen; Adult; Animals; Antigens, Neoplasm; Epoxide Hydrolases; Female; Humans; Liver Neoplas | 1984 |
Carcinogenicity of analgesics: long-term treatment of Sprague-Dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen).
Topics: Acetaminophen; Adenocarcinoma; Analgesics; Animals; Antipyrine; Caffeine; Carcinogens; Carcinoma, Sq | 1981 |
HepG2 cells: an in vitro model for P450-dependent metabolism of acetaminophen.
Topics: Acetaminophen; Acetone; Biotransformation; Carcinoma, Hepatocellular; Cytochrome P-450 CYP1A1; Cytoc | 1993 |
Acetaminophen-induced toxicity to human epidermoid cell line A431 and hepatoblastoma cell line Hep G2, in vitro, is diminished by silymarin.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Cell Line; Glutathione; Hepatoblastoma; Human | 1995 |
Rifampicin and isoniazid increase acetaminophen and isoniazid cytotoxicity in human HepG2 hepatoma cells.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antitubercular Agents; Carcinoma, Hepatocellular; Cell Surv | 1997 |
Establishment of a human hepatoma cell line, HLE/2E1, suitable for detection of p450 2E1-related cytotoxicity.
Topics: Acetaminophen; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cell Division; Cell Line, Transfor | 2000 |
Differential effects of acetaminophen pretreatment on hepatic aflatoxin B(1)-DNA binding, cellular proliferation, and aflatoxin B1-induced hepatic foci in rats and hamsters.
Topics: Acetaminophen; Aflatoxin B1; Analgesics, Non-Narcotic; Animals; Cell Division; Cricetinae; DNA; Glut | 2001 |
Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Apoptosis; Carcinoma, Hepatocellular; Cell | 2002 |
Serum alpha-fetoprotein levels in patients with acute and chronic liver disease. Relation to hepatocellular regeneration and development of primary liver cell carcinoma.
Topics: Acetaminophen; Acute Disease; Adult; alpha-Fetoproteins; Carcinoma, Hepatocellular; Chronic Disease; | 1977 |
Methyldopa binding to cells in culture.
Topics: Acetaminophen; Allopurinol; Animals; Ascorbic Acid; Carcinoma, Hepatocellular; Cells, Cultured; Defe | 1977 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Animals; Chemical and Drug Induced Liver Injury; Chronic Disease; Contraceptiv | 1979 |
Hepatic reactions to drugs.
Topics: Acetaminophen; Adenoma; Adult; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1979 |
Elimination of paracetamol in chronic liver disease.
Topics: Acetaminophen; Adolescent; Adult; Aged; Bilirubin; Humans; Liver Cirrhosis; Liver Neoplasms; Middle | 1978 |
Increased oxidative metabolism of paracetamol in patients with hepatocellular carcinoma.
Topics: Acetaminophen; Acetylcysteine; Adult; Carcinoma, Hepatocellular; Chromatography, High Pressure Liqui | 1991 |
Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers.
Topics: Acetaminophen; Adolescent; Adult; Benzopyrenes; Bilirubin; Carcinoma, Hepatocellular; Enzyme Inducti | 1987 |
[Paracetamol and liver damage in a new light: are findings of tumors Gn mice and rats relevant for the clinical situation?].
Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Humans; Liver; Liver Neoplasms; Mice; Rats | 1985 |
Effect of p-hydroxyacetanilide on liver cancer induction by N hydroxy-N-2-fluorenylacetamide.
Topics: Acetaminophen; Administration, Oral; Animals; Carcinoma, Hepatocellular; Esters; Fluorenes; Hydroxam | 1973 |
Effect of acetanilide and p-hydroxyacetanilide on the carcinogenicity of N-2-fluorenylacetamide and N-hydroxy-N-2-fluorenylacetamide in mice, hamsters, and female rats.
Topics: Acetamides; Acetaminophen; Acetanilides; Animals; Carcinogens; Cricetinae; Diet; Female; Fluorenes; | 1973 |