acetaminophen has been researched along with Cancer of Kidney in 31 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a nested, matched case-control study in the General Practice Research Database (GPRD) to assess whether acetaminophen use is associated with renal or bladder cancer." | 7.71 | Acetaminophen and the risk of renal and bladder cancer in the general practice research database. ( Jick, H; Kaye, JA; Myers, MW, 2001) |
| "Acetaminophen is a metabolite of phenacetin, a drug that has been implicated as a causal agent in the development of renal and bladder cancer." | 7.69 | Acetaminophen and renal and bladder cancer. ( Derby, LE; Jick, H, 1996) |
| "We describe a case of a 5-year-old female with stage III Wilms tumor who had recurrent VCR-associated fever that was controlled with prophylactic dexamethasone and acetaminophen." | 4.12 | Recurrent vincristine-associated fever in a child with Wilms tumor. ( Al-Antary, ET; Ramiz, S, 2022) |
| "We conducted a nested, matched case-control study in the General Practice Research Database (GPRD) to assess whether acetaminophen use is associated with renal or bladder cancer." | 3.71 | Acetaminophen and the risk of renal and bladder cancer in the general practice research database. ( Jick, H; Kaye, JA; Myers, MW, 2001) |
| "Acetaminophen is a metabolite of phenacetin, a drug that has been implicated as a causal agent in the development of renal and bladder cancer." | 3.69 | Acetaminophen and renal and bladder cancer. ( Derby, LE; Jick, H, 1996) |
| "Finally, patient satisfaction with postoperative pain control was significantly higher in the FT group." | 2.71 | Efficacy and safety of fast-track recovery strategy for patients undergoing laparoscopic nephrectomy. ( Cadeddu, JA; Duchene, D; Johnson, DB; Recart, A; Thomas, T; White, PF, 2005) |
| "Approximately 75% of patients with tuberous sclerosis complex develop renal angiomyolipomas." | 2.41 | Reduction of postembolization syndrome after ablation of renal angiomyolipoma. ( Bissler, JJ; Donnelly, LF; Johnson, ND; Racadio, J, 2002) |
| " However, chronic use of high doses of paracetamol should be avoided, probably also consumption of paracetamol in combination with ASA." | 2.39 | [Paracetamol--kidney and urinary tract. A cause of analgetic nephropathy or cancer?]. ( Berg, KJ, 1994) |
| " There was no evidence of a dose-response for duration of use of paracetamol (linear trend p = 0." | 1.62 | Analgesic use and the risk of renal cell carcinoma - Findings from the Consortium for the Investigation of Renal Malignancies (CONFIRM) study. ( Aitken, T; Bassett, JK; Bruinsma, FJ; Carroll, R; Davis, ID; Dudding-Byth, T; English, DR; Giles, GG; Jefford, M; Jenkins, M; Jordan, S; MacInnis, RJ; Milne, RL; Severi, G; Tucker, K; Walsh, J; Winship, I, 2021) |
| " The main pharmacokinetic parameters of paracetamol in the TN vs." | 1.46 | THE EFFECT OF TOTAL AND PARTIAL NEPHRECTOMY ON THE PHARMACOKINETICS OF INTRAVENOUS PARACETAMOL IN HUMANS. ( Grabowski, T; Grzesowiak, E; Karbownik, A; Polom, W; Porazka, J; Szalek, E; Wolc, A, 2017) |
| " There was a dose-response relationship between duration of nonaspirin NSAID use and RCC risk; compared with nonregular use, the pooled multivariate relative risks were 0." | 1.37 | Prospective evaluation of analgesic use and risk of renal cell cancer. ( Atkins, MB; Cho, E; Choueiri, TK; Curhan, G; Hankinson, SE; Kantoff, P; Stampfer, M, 2011) |
| " We report a severely malnourished 53-year-old woman who developed severe hepatotoxicity whilst receiving paracetamol at recommended dosage (4 g daily) following a period of fasting, in the absence of enzyme-inducing agents." | 1.32 | Paracetamol-induced hepatotoxicity at recommended dosage. ( Kurtovic, J; Riordan, SM, 2003) |
| " Results from this work demonstrate that, in the absence of CYP1A2, phenacetin is more toxic than in controls." | 1.30 | Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice. ( Coakley, CJ; Gonzalez, FJ; Kimura, S; Morishima, H; Peters, JM; Ward, JM, 1999) |
| "Although heavy or long-term use of analgesics has been related to risk of renal cell cancer in several studies, evidence for such an association remains inconclusive." | 1.29 | Use of analgesics and risk of renal cell cancer. ( Chow, WH; Linet, MS; Mandel, JS; McLaughlin, JK; Niwa, S, 1994) |
| " In contrast, only DEHP and BBS induced toxic renal lesions." | 1.27 | The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated with car ( Anderson, LM; Diwan, BA; Hagiwara, A; Lindsey, K; Ward, JM, 1988) |
| " Long-term use (greater than 36 mo) of phenacetin-containing products was associated in both sexes with a twofold increased risk for renal cell cancer." | 1.27 | Relation of analgesic use to renal cancer: population-based findings. ( Blot, WJ; Fraumeni, JF; McLaughlin, JK; Mehl, ES, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (35.48) | 18.7374 |
| 1990's | 11 (35.48) | 18.2507 |
| 2000's | 4 (12.90) | 29.6817 |
| 2010's | 3 (9.68) | 24.3611 |
| 2020's | 2 (6.45) | 2.80 |
| Authors | Studies |
|---|---|
| Bruinsma, FJ | 1 |
| Jordan, S | 1 |
| Bassett, JK | 1 |
| Severi, G | 1 |
| MacInnis, RJ | 1 |
| Walsh, J | 1 |
| Aitken, T | 1 |
| Jenkins, M | 1 |
| Carroll, R | 1 |
| Jefford, M | 1 |
| Davis, ID | 1 |
| Tucker, K | 1 |
| Dudding-Byth, T | 1 |
| English, DR | 1 |
| Giles, GG | 1 |
| Winship, I | 1 |
| Milne, RL | 1 |
| Al-Antary, ET | 1 |
| Ramiz, S | 1 |
| Karbownik, A | 1 |
| Polom, W | 1 |
| Porazka, J | 1 |
| Szalek, E | 1 |
| Grabowski, T | 1 |
| Wolc, A | 1 |
| Grzesowiak, E | 1 |
| Cho, E | 1 |
| Curhan, G | 1 |
| Hankinson, SE | 1 |
| Kantoff, P | 1 |
| Atkins, MB | 1 |
| Stampfer, M | 1 |
| Choueiri, TK | 1 |
| Fenner, A | 1 |
| Kurtovic, J | 1 |
| Riordan, SM | 1 |
| Recart, A | 1 |
| Duchene, D | 1 |
| White, PF | 1 |
| Thomas, T | 1 |
| Johnson, DB | 1 |
| Cadeddu, JA | 1 |
| Tsuda, H | 3 |
| Sakata, T | 3 |
| Masui, T | 1 |
| Imaida, K | 2 |
| Ito, N | 3 |
| Fukushima, S | 1 |
| Johansson, SL | 1 |
| Linet, MS | 2 |
| Chow, WH | 2 |
| McLaughlin, JK | 3 |
| Wacholder, S | 1 |
| Yu, MC | 2 |
| Schoenberg, JB | 1 |
| Lynch, C | 1 |
| Fraumeni, JF | 2 |
| Niwa, S | 1 |
| Mandel, JS | 1 |
| Berg, KJ | 1 |
| McCredie, M | 2 |
| Stewart, JH | 2 |
| Day, NE | 1 |
| Vanchieri, C | 1 |
| Kliem, V | 1 |
| Thon, W | 1 |
| Krautzig, S | 1 |
| Kolditz, M | 1 |
| Behrend, M | 1 |
| Pichlmayr, R | 1 |
| Koch, KM | 1 |
| Frei, U | 1 |
| Brunkhorst, R | 1 |
| Derby, LE | 1 |
| Jick, H | 2 |
| Rosenberg, L | 1 |
| Rao, RS | 1 |
| Palmer, JR | 1 |
| Strom, BL | 1 |
| Zauber, A | 1 |
| Warshauer, ME | 1 |
| Stolley, PD | 1 |
| Shapiro, S | 1 |
| Peters, JM | 1 |
| Morishima, H | 1 |
| Ward, JM | 2 |
| Coakley, CJ | 1 |
| Kimura, S | 1 |
| Gonzalez, FJ | 1 |
| Gago-Dominguez, M | 1 |
| Yuan, JM | 1 |
| Castelao, JE | 1 |
| Ross, RK | 1 |
| Kaye, JA | 1 |
| Myers, MW | 1 |
| Bissler, JJ | 1 |
| Racadio, J | 1 |
| Donnelly, LF | 1 |
| Johnson, ND | 1 |
| Brunner, FP | 1 |
| Richtmann, L | 1 |
| Thiel, G | 1 |
| Dubach, UC | 1 |
| Hagiwara, A | 1 |
| Anderson, LM | 1 |
| Lindsey, K | 1 |
| Diwan, BA | 1 |
| Kurata, Y | 1 |
| Yamashita, T | 1 |
| Blot, WJ | 1 |
| Mehl, ES | 1 |
| Bengtsson, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Erector Spinae Plane Block (ESPB): A New Technique for Perioperative Pain Control in Patients Undergoing Surgery Through a Flank or Anterior Subcostal Incision.[NCT03691935] | Phase 4 | 40 participants (Anticipated) | Interventional | 2018-09-28 | Enrolling by invitation | ||
| Ambulant Laparoscopic Nephrectomy[NCT01600157] | 62 participants (Actual) | Interventional | 2013-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for acetaminophen and Cancer of Kidney
| Article | Year |
|---|---|
[Paracetamol--kidney and urinary tract. A cause of analgetic nephropathy or cancer?].
Topics: Acetaminophen; Drug Utilization; Humans; Kidney; Kidney Diseases; Kidney Neoplasms; Scandinavian and | 1994 |
Paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carcinogens; Chemical and Drug Induced Liver Injur | 1999 |
Reduction of postembolization syndrome after ablation of renal angiomyolipoma.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Angiography; Angiomyolipoma; Catheter Ablation; Drug | 2002 |
[Tumors of the efferent parts of the urinary tract and abuse of analgesics].
Topics: Acetaminophen; Adult; Analgesics; Carcinoma, Squamous Cell; Choriocarcinoma; Female; Humans; Kidney | 1978 |
Unravelling analgesic nephropathy.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Carcinoma, Transitional Cell; Female; Humans; Kidney Ne | 1972 |
1 trial available for acetaminophen and Cancer of Kidney
| Article | Year |
|---|---|
Efficacy and safety of fast-track recovery strategy for patients undergoing laparoscopic nephrectomy.
Topics: Acetaminophen; Adult; Aged; Analgesics; Antiemetics; Cyclooxygenase 2 Inhibitors; Female; Histamine | 2005 |
Efficacy and safety of fast-track recovery strategy for patients undergoing laparoscopic nephrectomy.
Topics: Acetaminophen; Adult; Aged; Analgesics; Antiemetics; Cyclooxygenase 2 Inhibitors; Female; Histamine | 2005 |
Efficacy and safety of fast-track recovery strategy for patients undergoing laparoscopic nephrectomy.
Topics: Acetaminophen; Adult; Aged; Analgesics; Antiemetics; Cyclooxygenase 2 Inhibitors; Female; Histamine | 2005 |
Efficacy and safety of fast-track recovery strategy for patients undergoing laparoscopic nephrectomy.
Topics: Acetaminophen; Adult; Aged; Analgesics; Antiemetics; Cyclooxygenase 2 Inhibitors; Female; Histamine | 2005 |
25 other studies available for acetaminophen and Cancer of Kidney
| Article | Year |
|---|---|
Analgesic use and the risk of renal cell carcinoma - Findings from the Consortium for the Investigation of Renal Malignancies (CONFIRM) study.
Topics: Acetaminophen; Analgesics; Australia; Carcinoma, Renal Cell; Female; Humans; Kidney Neoplasms | 2021 |
Recurrent vincristine-associated fever in a child with Wilms tumor.
Topics: Acetaminophen; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dexamethason | 2022 |
THE EFFECT OF TOTAL AND PARTIAL NEPHRECTOMY ON THE PHARMACOKINETICS OF INTRAVENOUS PARACETAMOL IN HUMANS.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Antipyretics; Area Under Cu | 2017 |
Prospective evaluation of analgesic use and risk of renal cell cancer.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, R | 2011 |
Kidney cancer: long-term use of nonaspirin NSAIDs increases RCC risk.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Renal Cell; Follow-Up Studies; Hu | 2011 |
Paracetamol-induced hepatotoxicity at recommended dosage.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anus Neoplasms; Brachytherapy; Carcinoma, Renal Cell; Chemi | 2003 |
Modifying effects of butylated hydroxyanisole, ethoxyquin and acetaminophen on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine.
Topics: Acetaminophen; Adenocarcinoma; Animals; Anisoles; Butylated Hydroxyanisole; Carcinogens; Diethylnitr | 1984 |
Modification of carcinogenesis by antioxidants and other compounds.
Topics: Acetaminophen; Animals; Antioxidants; Body Weight; Butylated Hydroxyanisole; Carcinogens; Diethylnit | 1984 |
Carcinogenicity of analgesics: long-term treatment of Sprague-Dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen).
Topics: Acetaminophen; Adenocarcinoma; Analgesics; Animals; Antipyrine; Caffeine; Carcinogens; Carcinoma, Sq | 1981 |
Analgesics and cancers of the renal pelvis and ureter.
Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Case-Control Studies; Female; Humans; Kidney Neopla | 1995 |
Use of analgesics and risk of renal cell cancer.
Topics: Acetaminophen; Adult; Aged; Aspirin; Carcinoma, Renal Cell; Case-Control Studies; Drug Combinations; | 1994 |
Different roles for phenacetin and paracetamol in cancer of the kidney and renal pelvis.
Topics: Acetaminophen; Adult; Aged; Aspirin; Carcinoma, Renal Cell; Case-Control Studies; Drug Combinations; | 1993 |
Australian study links certain analgesics to renal cancers.
Topics: Acetaminophen; Australia; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Phenacetin; Risk | 1993 |
High mortality from urothelial carcinoma despite regular tumor screening in patients with analgesic nephropathy after renal transplantation.
Topics: Acetaminophen; Adult; Aged; Analgesics; Carcinoma, Renal Cell; Female; Humans; Kidney Failure, Chron | 1996 |
Acetaminophen and renal and bladder cancer.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Case-Control Studies; Drug Prescriptions; Fema | 1996 |
Transitional cell cancer of the urinary tract and renal cell cancer in relation to acetaminophen use (United States).
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Carcinoma, Renal Cell; Carcinoma, Transitional | 1998 |
Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice.
Topics: Acetaminophen; Animals; Carcinogens; Carcinoma; Cytochrome P-450 CYP1A2; Female; Kidney Neoplasms; M | 1999 |
Regular use of analgesics is a risk factor for renal cell carcinoma.
Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Carcinoma, Renal Cell; Case-Control Studies; Dose-R | 1999 |
Acetaminophen and the risk of renal and bladder cancer in the general practice research database.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Case-Control Studies; Databases, Factual; Family Prac | 2001 |
The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated with car
Topics: Acetaminophen; Animals; Autoradiography; Barbital; Barbiturates; Diethylhexyl Phthalate; DNA; Immuno | 1988 |
Does paracetamol cause urothelial cancer or renal papillary necrosis?
Topics: Acetaminophen; Carcinoma, Transitional Cell; Female; Humans; Kidney Neoplasms; Kidney Papillary Necr | 1988 |
Reciprocal modifying effects of isomeric forms of aminophenol on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine.
Topics: Acetaminophen; Aminophenols; Animals; Body Weight; Diethylnitrosamine; Glutathione Transferase; Kidn | 1987 |
Relation of analgesic use to renal cancer: population-based findings.
Topics: Acetaminophen; Adult; Analgesics; Aspirin; Carcinoma, Renal Cell; Female; Humans; Kidney Neoplasms; | 1985 |
Phenacetin.
Topics: Acetaminophen; Antipyrine; Denmark; Humans; Kidney Diseases; Kidney Neoplasms; Kidney Papillary Necr | 1969 |
[Abuse of phenacetin-containing analgesics--kidney pelvis neoplasms].
Topics: Acetaminophen; Drug Synergism; Humans; Kidney Neoplasms; Phenacetin | 1970 |