Page last updated: 2024-10-22

acetaminophen and Breathing Sounds

acetaminophen has been researched along with Breathing Sounds in 35 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

ExcerptRelevanceReference
"We conducted a meta-analysis of randomized controlled trials (RCTs) that compared wheezing and asthma exacerbations in children taking paracetamol versus ibuprofen."9.05Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials. ( Furuya-Kanamori, L; Nader, JD; Sherbash, M; Thalib, L, 2020)
"The possible association between acetaminophen use during pregnancy and childhood asthma has been a subject of interest based on the theory that acetaminophen metabolism may deplete glutathione in the developing lung, leading to oxidative damage and inflammation."8.86Childhood asthma and use during pregnancy of acetaminophen. A critical review. ( Ang, R; Breitmeyer, J; Royal, MA; Scialli, AR, 2010)
"Although many studies have investigated the safety and tolerability of ibuprofen or acetaminophen (paracetamol) use in children, few have specifically examined the association of ibuprofen or acetaminophen and the occurrence of asthma in pediatric populations."8.84A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. ( Dale, S; Kanabar, D; Rawat, M, 2007)
"We did a retrospective study comparing the effect of prescribing acetaminophen, ibuprofen, or neither for a first episode of bronchiolitis on medical attendances for subsequent wheezing in infants younger than 12 months."7.88Wheezing after the use of acetaminophen and or ibuprofen for first episode of bronchiolitis or respiratory tract infection. ( Rothenberg, SJ; Walsh, P, 2018)
"Unadjusted models showed an increased asthma risk in early childhood for higher infant acetaminophen (odds ratio [OR], 1."7.81Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children. ( Bunyavanich, S; Camargo, CA; Gillman, MW; Gold, DR; Litonjua, AA; Rifas-Shiman, SL; Scirica, CV; Sordillo, JE; Weiss, ST, 2015)
" At ages 1 and 3, questionnaire data were collected on wheeze, eczema, child's use of acetaminophen, and various potential confounders, along with a stool sample for geohelminth analysis."7.77The role of acetaminophen and geohelminth infection on the incidence of wheeze and eczema: a longitudinal birth-cohort study. ( Alem, A; Amberbir, A; Britton, J; Davey, G; Medhin, G; Venn, A, 2011)
"We conducted a meta-analysis of randomized controlled trials (RCTs) that compared wheezing and asthma exacerbations in children taking paracetamol versus ibuprofen."5.05Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials. ( Furuya-Kanamori, L; Nader, JD; Sherbash, M; Thalib, L, 2020)
" To perform the search for the most suitable and representative articles, keywords were selected ("asthma," "paracetamol" and "acetaminophen")."4.95The association between paracetamol and asthma is still under debate. ( Gonzalez-Barcala, FJ; Lourido-Cebreiro, T; Salgado, FJ; Valdes, L, 2017)
"Although the use of acetaminophen is weakly associated with asthma/wheezing, the widespread use of the drug might have important public health implications."4.87Early exposure to acetaminophen and allergic disorders. ( Garcia-Marcos, L; Perez-Fernandez, V; Sanchez-Solis, M, 2011)
"The possible association between acetaminophen use during pregnancy and childhood asthma has been a subject of interest based on the theory that acetaminophen metabolism may deplete glutathione in the developing lung, leading to oxidative damage and inflammation."4.86Childhood asthma and use during pregnancy of acetaminophen. A critical review. ( Ang, R; Breitmeyer, J; Royal, MA; Scialli, AR, 2010)
"Although many studies have investigated the safety and tolerability of ibuprofen or acetaminophen (paracetamol) use in children, few have specifically examined the association of ibuprofen or acetaminophen and the occurrence of asthma in pediatric populations."4.84A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. ( Dale, S; Kanabar, D; Rawat, M, 2007)
"We did a retrospective study comparing the effect of prescribing acetaminophen, ibuprofen, or neither for a first episode of bronchiolitis on medical attendances for subsequent wheezing in infants younger than 12 months."3.88Wheezing after the use of acetaminophen and or ibuprofen for first episode of bronchiolitis or respiratory tract infection. ( Rothenberg, SJ; Walsh, P, 2018)
"Unadjusted models showed an increased asthma risk in early childhood for higher infant acetaminophen (odds ratio [OR], 1."3.81Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children. ( Bunyavanich, S; Camargo, CA; Gillman, MW; Gold, DR; Litonjua, AA; Rifas-Shiman, SL; Scirica, CV; Sordillo, JE; Weiss, ST, 2015)
" At ages 1 and 3, questionnaire data were collected on wheeze, eczema, child's use of acetaminophen, and various potential confounders, along with a stool sample for geohelminth analysis."3.77The role of acetaminophen and geohelminth infection on the incidence of wheeze and eczema: a longitudinal birth-cohort study. ( Alem, A; Amberbir, A; Britton, J; Davey, G; Medhin, G; Venn, A, 2011)
"Acetaminophen has been associated with asthma and is in part metabolised via the glutathione pathway."3.76Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort. ( Ali, D; Barr, RG; Chew, GL; Garfinkel, RS; Goldstein, IF; Miller, RL; Perera, FP; Perzanowski, MS; Tang, D, 2010)
"Use of acetaminophen in middle to late but not early pregnancy was significantly related to wheezing (odd ratio, 1."3.74Prenatal exposure to acetaminophen and respiratory symptoms in the first year of life. ( Busso, A; Chavez, N; Enriquez, R; Gutierrez, S; Hernandez, E; Pelzel, D; Persky, V; Piorkowski, J; Vergara, C; Wagner-Cassanova, C, 2008)
"We recently found that paracetamol (acetaminophen) use in late pregnancy was associated with an increased risk of early wheezing in the offspring."3.73Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood. ( Headley, JE; Henderson, AJ; Jones, RW; Newson, RB; Shaheen, SO; Strachan, DP; Stratton, FD, 2005)
"We recently reported links between frequent paracetamol (acetaminophen) use and wheezing and asthma in adults and children, but data are lacking on possible effects of prenatal exposure on wheezing in early childhood."3.71Paracetamol use in pregnancy and wheezing in early childhood. ( Burney, PG; Golding, J; Henderson, AJ; Heron, JE; Newson, RB; Shaheen, SO; Sherriff, A, 2002)
"Ibuprofen use was significantly lower in children diagnosed with wheezing (n = 22, 52."1.46Association of Acetaminophen and Ibuprofen Use With Wheezing in Children With Acute Febrile Illness. ( Elizur, A; Ganor, S; Kozer, E; Levine, H; Matok, I; Perlman, A, 2017)
" Significant positive dose-response effects of early life use were seen in relation to the prevalence of all outcomes at age 5."1.40Effects of early life paracetamol use on the incidence of allergic disease and sensitization: 5 year follow-up of an Ethiopian birth cohort. ( Amberbir, A; Britton, J; Davey, G; Hanlon, C; Medhin, G; Venn, A, 2014)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (31.43)29.6817
2010's21 (60.00)24.3611
2020's3 (8.57)2.80

Authors

AuthorsStudies
Liew, Z1
Yuan, Y1
Meng, Q1
von Ehrenstein, OS1
Cui, X1
Flores, MES1
Ritz, B1
Damkier, P1
Cleary, B1
Weber-Schoendorfer, C1
Shechtman, S1
Cassina, M1
Panchaud, A1
Diav-Cirtin, O1
Sherbash, M1
Furuya-Kanamori, L1
Nader, JD1
Thalib, L1
Piler, P1
Švancara, J1
Kukla, L1
Pikhart, H1
Williams, TC1
Bach, CC1
Matthiesen, NB1
Henriksen, TB1
Gagliardi, L2
Walsh, P1
Rothenberg, SJ1
Amberbir, A2
Medhin, G2
Hanlon, C1
Britton, J2
Davey, G2
Venn, A2
Sordillo, JE1
Scirica, CV1
Rifas-Shiman, SL1
Gillman, MW1
Bunyavanich, S1
Camargo, CA1
Weiss, ST1
Gold, DR1
Litonjua, AA1
Shaheen, SO4
Lourido-Cebreiro, T1
Salgado, FJ1
Valdes, L1
Gonzalez-Barcala, FJ1
Matok, I1
Elizur, A1
Perlman, A1
Ganor, S1
Levine, H1
Kozer, E1
Barr, RG2
Persky, V1
Piorkowski, J1
Hernandez, E1
Chavez, N1
Wagner-Cassanova, C1
Vergara, C1
Pelzel, D1
Enriquez, R1
Gutierrez, S1
Busso, A1
Garcia-Marcos, L2
Sanchez-Solis, M2
Perez-Fernandez, V2
Pastor-Vivero, MD1
Mondejar-Lopez, P1
Valverde-Molina, J1
Mitchell, EA1
Stewart, AW1
Clayton, T1
Asher, MI1
Ellwood, P1
Mackay, R1
Moyes, C1
Pattemore, PK1
Pearce, N1
Perzanowski, MS1
Miller, RL1
Tang, D1
Ali, D1
Garfinkel, RS1
Chew, GL1
Goldstein, IF1
Perera, FP1
Scialli, AR1
Ang, R1
Breitmeyer, J1
Royal, MA1
Alem, A1
Verd, S1
Nadal-Amat, J1
Rusconi, F1
Galassi, C1
Forastiere, F1
Brunetti, L1
La Grutta, S1
Piffer, S1
Talassi, F1
Eyers, S1
Weatherall, M1
Jefferies, S1
Beasley, R1
Lowe, AJ1
Dharmage, SC1
Abramson, MJ1
Chang, KC1
Leung, CC1
Tam, CM1
Kong, FY1
Goksör, E1
Thengilsdottir, H1
Alm, B1
Norvenius, G1
Wennergren, G1
Raza, A1
Kurukulaaratchy, RJ1
Grundy, JD1
Clayton, CB1
Mitchell, FA1
Roberts, G1
Ewart, S1
Sadeghnejad, A1
Arshad, SH1
Selbst, SM1
Osterhoudt, K1
Newson, RB2
Sherriff, A1
Henderson, AJ2
Heron, JE1
Burney, PG1
Golding, J1
Nuttall, SL1
Williams, J1
Kendall, MJ1
Mannarino, E1
Lupattelli, G1
Schillaci, G1
Headley, JE1
Stratton, FD1
Jones, RW1
Strachan, DP1
Barragán-Meijueiro, MM1
Morfín-Maciel, B1
Nava-Ocampo, AA1
Kanabar, D1
Dale, S1
Rawat, M1
Rebordosa, C1
Kogevinas, M1
Sørensen, HT1
Olsen, J1

Reviews

8 reviews available for acetaminophen and Breathing Sounds

ArticleYear
Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials.
    BMC pulmonary medicine, 2020, Mar-23, Volume: 20, Issue:1

    Topics: Acetaminophen; Asthma; Child; Disease Progression; Humans; Ibuprofen; Randomized Controlled Trials a

2020
Directed acyclic graphs: a tool for causal studies in paediatrics.
    Pediatric research, 2018, Volume: 84, Issue:4

    Topics: Acetaminophen; Bias; Causality; Child; Confounding Factors, Epidemiologic; Data Display; Data Interp

2018
The association between paracetamol and asthma is still under debate.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2017, 01-02, Volume: 54, Issue:1

    Topics: Acetaminophen; Asthma; Child, Preschool; Female; Glutathione; Humans; Infant; Infant, Newborn; Perox

2017
Childhood asthma and use during pregnancy of acetaminophen. A critical review.
    Reproductive toxicology (Elmsford, N.Y.), 2010, Volume: 30, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipyretics; Asthma; Child; Child, Preschool; Confounding

2010
Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta-analysis.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2011, Volume: 41, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child; Female; Humans; Pregnancy; Prenatal Exposure

2011
Early exposure to acetaminophen and allergic disorders.
    Current opinion in allergy and clinical immunology, 2011, Volume: 11, Issue:3

    Topics: Acetaminophen; Asthma; Drug Hypersensitivity; Female; Humans; Maternal Exposure; Pregnancy; Prenatal

2011
Does paracetamol cause asthma?
    Journal of clinical pharmacy and therapeutics, 2003, Volume: 28, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Asthma; Female; Free Radicals; Glutathione; Humans

2003
A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms.
    Clinical therapeutics, 2007, Volume: 29, Issue:12

    Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Asthma; Child; Fever; Hospitalization; Humans;

2007

Other Studies

27 other studies available for acetaminophen and Breathing Sounds

ArticleYear
Prenatal Exposure to Acetaminophen and Childhood Asthmatic Symptoms in a Population-Based Cohort in Los Angeles, California.
    International journal of environmental research and public health, 2021, 09-26, Volume: 18, Issue:19

    Topics: Acetaminophen; Asthma; Child; Female; Humans; Los Angeles; Pregnancy; Prenatal Exposure Delayed Effe

2021
Handle with care - interpretation, synthesis and dissemination of data on paracetamol in pregnancy.
    Nature reviews. Endocrinology, 2022, Volume: 18, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Pregnancy; Respiratory Sounds

2022
Role of combined prenatal and postnatal paracetamol exposure on asthma development: the Czech ELSPAC study.
    Journal of epidemiology and community health, 2018, Volume: 72, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child, Preschool; Czech Republic; Female; Humans; I

2018
Wheezing after the use of acetaminophen and or ibuprofen for first episode of bronchiolitis or respiratory tract infection.
    PloS one, 2018, Volume: 13, Issue:9

    Topics: Acetaminophen; Antipyretics; Bronchiolitis; Humans; Ibuprofen; Incidence; Infant; Infant, Newborn; L

2018
Effects of early life paracetamol use on the incidence of allergic disease and sensitization: 5 year follow-up of an Ethiopian birth cohort.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Acetaminophen; Age of Onset; Asthma; Child, Preschool; Cohort Studies; Cross-Sectional Studies; Deve

2014
Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children.
    The Journal of allergy and clinical immunology, 2015, Volume: 135, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chi

2015
Acetaminophen and childhood asthma: pill-popping at our peril?
    The Journal of allergy and clinical immunology, 2015, Volume: 135, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Female; Hu

2015
Association of Acetaminophen and Ibuprofen Use With Wheezing in Children With Acute Febrile Illness.
    The Annals of pharmacotherapy, 2017, Volume: 51, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipyretics; Asthma; Child; Child, Preschool; Cross-Sectio

2017
Does paracetamol cause asthma in children? Time to remove the guesswork.
    Lancet (London, England), 2008, Sep-20, Volume: 372, Issue:9643

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asthma; Child; Female; Humans; Infant; Male; Randomi

2008
Prenatal exposure to acetaminophen and respiratory symptoms in the first year of life.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2008, Volume: 101, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Asthma; Breast Feeding; Cough; Female; H

2008
Is the effect of prenatal paracetamol exposure on wheezing in preschool children modified by asthma in the mother?
    International archives of allergy and immunology, 2009, Volume: 149, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child, Preschool; Female; Humans; Male; Mothers; Pr

2009
Cross-sectional survey of risk factors for asthma in 6-7-year-old children in New Zealand: International Study of Asthma and Allergy in Childhood Phase Three.
    Journal of paediatrics and child health, 2009, Volume: 45, Issue:6

    Topics: Acetaminophen; Air Pollutants; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Asthma; Child; Cross

2009
Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort.
    Thorax, 2010, Volume: 65, Issue:2

    Topics: Acetaminophen; Allergens; Analgesics, Non-Narcotic; Asthma; Child, Preschool; Female; Genetic Predis

2010
The role of acetaminophen and geohelminth infection on the incidence of wheeze and eczema: a longitudinal birth-cohort study.
    American journal of respiratory and critical care medicine, 2011, Jan-15, Volume: 183, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Causality; Child, Preschool; Cohort Studies; Comorbidity; D

2011
Paracetamol and asthma and lactation.
    Acta paediatrica (Oslo, Norway : 1992), 2011, Volume: 100, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Breast Feeding; Female; Humans; Infant; Infant, New

2011
Paracetamol and antibiotics in childhood and subsequent development of wheezing/asthma: association or causation?
    International journal of epidemiology, 2011, Volume: 40, Issue:3

    Topics: Acetaminophen; Adolescent; Age Distribution; Age of Onset; Anti-Bacterial Agents; Asthma; Child; Cro

2011
Paracetamol use for non-respiratory indications and subsequent asthma: a valuable way to eliminate confounding by respiratory infections.
    International journal of epidemiology, 2011, Volume: 40, Issue:5

    Topics: Acetaminophen; Anti-Bacterial Agents; Asthma; Female; Humans; Male; Respiratory Sounds

2011
Commentary: Paracetamol and asthma--lessons from the antibiotic hypothesis?
    International journal of epidemiology, 2011, Volume: 40, Issue:3

    Topics: Acetaminophen; Anti-Bacterial Agents; Asthma; Female; Humans; Male; Respiratory Sounds

2011
Acetaminophen and asthma: spurious association?
    American journal of respiratory and critical care medicine, 2011, Jun-01, Volume: 183, Issue:11

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Bias; Child, Preschool; Dose-Response Relationship,

2011
Prenatal paracetamol exposure and risk of wheeze at preschool age.
    Acta paediatrica (Oslo, Norway : 1992), 2011, Volume: 100, Issue:12

    Topics: Acetaminophen; Administration, Inhalation; Adrenal Cortex Hormones; Child, Preschool; Female; Humans

2011
What does adolescent undiagnosed wheeze represent? Findings from the Isle of Wight Cohort.
    The European respiratory journal, 2012, Volume: 40, Issue:3

    Topics: Acetaminophen; Adolescent; Antipyretics; Asthma; Child; Child, Preschool; Cohort Studies; Female; He

2012
Pediatric emergency medicine: legal briefs.
    Pediatric emergency care, 2012, Volume: 28, Issue:12

    Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aortic Aneurysm; Aortic Dissection; Appendicitis;

2012
Paracetamol use in pregnancy and wheezing in early childhood.
    Thorax, 2002, Volume: 57, Issue:11

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Asthma; Eczema; Female; Humans; Infant; Longitudin

2002
A 32-year-old woman with breast swelling and crepitant rales.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2004, Nov-09, Volume: 171, Issue:10

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Breast Diseases; Chest Pain; Diagnosis, Differential

2004
Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2005, Volume: 35, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; As

2005
A Mexican population-based study on exposure to paracetamol and the risk of wheezing, rhinitis, and eeczema in childhood.
    Journal of investigational allergology & clinical immunology, 2006, Volume: 16, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Case-Control Studies; Child; Child,

2006
Pre-natal exposure to paracetamol and risk of wheezing and asthma in children: a birth cohort study.
    International journal of epidemiology, 2008, Volume: 37, Issue:3

    Topics: Acetaminophen; Adult; Analgesics; Asthma; Bronchitis; Child; Denmark; Epidemiologic Methods; Female;

2008