acetaminophen has been researched along with Breakthrough Pain in 12 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Breakthrough Pain: Acute pain that comes on rapidly despite the use of pain medication.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The first-line use of ibuprofen rather than acetaminophen for postpartum pain did not lengthen the duration of severe-range hypertension in women with preeclampsia with severe features." | 9.27 | Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial. ( Blue, NR; Drake-Lavelle, S; Holbrook, BD; Katukuri, VR; Leeman, L; Mozurkewich, EL; Murray-Krezan, C; Weinberg, D, 2018) |
| "Patients with bone-cancer pain, already on opioids, obtain clinically important, additional pain-control, with regular oxycodone/paracetamol dosing." | 9.16 | Efficacy of oxycodone/paracetamol for patients with bone-cancer pain: a multicenter, randomized, double-blinded, placebo-controlled trial. ( Fang, WX; Li, F; Sima, L; Wu, XM, 2012) |
| " The patient was weaned from oxycodone ER 30 mg every 12 h and oxycodone/acetaminophen 10/325 mg 3x/day for breakthrough pain utilizing an unconventional approach." | 8.31 | Successful buprenorphine transition while overlapping with a full opioid agonist to treat chronic pain: a case report. ( Patel, KV; Sahni, S; Taylor, LF, 2023) |
| "To reduce postoperative pain by using additional analgesic agent in between the usual parenteral analgesia that is used in the postoperative period in surgical patients." | 6.87 | Effectiveness of acetaminophen in control of breakthrough pain: Randomized controlled trial. ( Bangash, AA; Durrani, Z, 2018) |
| "The first-line use of ibuprofen rather than acetaminophen for postpartum pain did not lengthen the duration of severe-range hypertension in women with preeclampsia with severe features." | 5.27 | Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial. ( Blue, NR; Drake-Lavelle, S; Holbrook, BD; Katukuri, VR; Leeman, L; Mozurkewich, EL; Murray-Krezan, C; Weinberg, D, 2018) |
| "Patients with bone-cancer pain, already on opioids, obtain clinically important, additional pain-control, with regular oxycodone/paracetamol dosing." | 5.16 | Efficacy of oxycodone/paracetamol for patients with bone-cancer pain: a multicenter, randomized, double-blinded, placebo-controlled trial. ( Fang, WX; Li, F; Sima, L; Wu, XM, 2012) |
| " The patient was weaned from oxycodone ER 30 mg every 12 h and oxycodone/acetaminophen 10/325 mg 3x/day for breakthrough pain utilizing an unconventional approach." | 4.31 | Successful buprenorphine transition while overlapping with a full opioid agonist to treat chronic pain: a case report. ( Patel, KV; Sahni, S; Taylor, LF, 2023) |
| " The protocol utilized oral celecoxib and scheduled oral acetaminophen for pain control, with opioids used only as needed for breakthrough pain." | 3.91 | Multimodal Postoperative Pain Control Is Effective and Reduces Opioid Use After Laparoscopic Roux-en-Y Gastric Bypass. ( Dove, J; Fluck, M; Gabrielsen, JD; Gionfriddo, MR; Horsley, RD; McField, DAP; Medico, C; Parker, DM; Petrick, AT; Vogels, ED, 2019) |
| " Patients were advised to use acetaminophen and ibuprofen, and were provided with a small "rescue" opioid prescription for breakthrough pain." | 3.91 | Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway. ( Brummett, C; Englesbe, M; Hallway, A; Howard, R; Lee, J; Palazzolo, W; Vu, J; Waljee, J, 2019) |
| " Group 1 was consisted of 353 patients whose basal cancer pain of intensity 4-7 NRS was treated weak opiates (basal analgetic- fixed combination of tramadol/paracetamol (37." | 3.85 | Characteristics and Treatment of Breakthrought Pain (BTcP) in Palliative Care. ( Husic, S; Imamovic, S; Matic, S; Sukalo, A, 2017) |
| "To reduce postoperative pain by using additional analgesic agent in between the usual parenteral analgesia that is used in the postoperative period in surgical patients." | 2.87 | Effectiveness of acetaminophen in control of breakthrough pain: Randomized controlled trial. ( Bangash, AA; Durrani, Z, 2018) |
| "The rate of pregnant women with an opioid use disorder has risen drastically in the past 20 years, paralleling that in the general population." | 2.66 | Opioid Use and Misuse in Pregnancy. ( Landau, R; Shatil, B, 2020) |
| "Pain is a hallmark of this condition and can be extremely difficult to control." | 1.56 | Pain management in patients with end-stage renal disease and calciphylaxis- a survey of clinical practices among physicians. ( Chinnadurai, R; Lowney, AC; Miller, M; Sinha, S, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 5 (41.67) | 2.80 |
| Authors | Studies |
|---|---|
| Patel, KV | 1 |
| Sahni, S | 1 |
| Taylor, LF | 1 |
| Evans, T | 1 |
| Nicholas, TA | 1 |
| Sutton, AV | 1 |
| Wysong, A | 1 |
| Chinnadurai, R | 1 |
| Sinha, S | 1 |
| Lowney, AC | 1 |
| Miller, M | 1 |
| Shatil, B | 1 |
| Landau, R | 1 |
| Yang, H | 1 |
| Lee, HH | 1 |
| Martin-Tuite, P | 1 |
| Chappidi, M | 1 |
| Bowman, M | 1 |
| Hamouche, F | 1 |
| Ahn, J | 1 |
| Stoller, M | 1 |
| Braehler, M | 1 |
| Chi, T | 1 |
| Husic, S | 1 |
| Imamovic, S | 1 |
| Matic, S | 1 |
| Sukalo, A | 1 |
| Blue, NR | 1 |
| Murray-Krezan, C | 1 |
| Drake-Lavelle, S | 1 |
| Weinberg, D | 1 |
| Holbrook, BD | 1 |
| Katukuri, VR | 1 |
| Leeman, L | 1 |
| Mozurkewich, EL | 1 |
| Bangash, AA | 1 |
| Durrani, Z | 1 |
| Horsley, RD | 1 |
| Vogels, ED | 1 |
| McField, DAP | 1 |
| Parker, DM | 1 |
| Medico, C | 1 |
| Dove, J | 1 |
| Fluck, M | 1 |
| Gabrielsen, JD | 1 |
| Gionfriddo, MR | 1 |
| Petrick, AT | 1 |
| Wilson, SH | 1 |
| Wolf, BJ | 1 |
| Robinson, SM | 1 |
| Nelson, C | 1 |
| Hebbar, L | 1 |
| Hallway, A | 1 |
| Vu, J | 1 |
| Lee, J | 1 |
| Palazzolo, W | 1 |
| Waljee, J | 1 |
| Brummett, C | 1 |
| Englesbe, M | 1 |
| Howard, R | 1 |
| Sima, L | 1 |
| Fang, WX | 1 |
| Wu, XM | 1 |
| Li, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Trial of Bupivacaine as Adjuvant for Post-operative Pain in Mohs Micrographic Surgery[NCT04362566] | Phase 4 | 174 participants (Actual) | Interventional | 2020-07-30 | Completed | ||
| Intravenous Versus Oral Acetaminophen for Postoperative Pain Control After Cesarean Delivery[NCT02487303] | 148 participants (Actual) | Interventional | 2015-03-17 | Completed | |||
| A Prospective Pilot Study of a Non-Narcotic Post-Operative Course After Colectomy[NCT05200806] | Phase 4 | 25 participants (Anticipated) | Interventional | 2022-02-07 | Recruiting | ||
| Assessing Perceived Quality of Care With Differing Pain Management Protocols After Outpatient Otolaryngology Procedures[NCT04976387] | Phase 3 | 150 participants (Actual) | Interventional | 2021-07-02 | Completed | ||
| STandard Versus No Opioid Prescription After Prolapse and Anti-INcontinence Surgery: A Randomized Controlled, Non-inferiority Trial[NCT04491617] | 148 participants (Actual) | Interventional | 2020-08-27 | Completed | |||
| Using Difference-in-Differences to Evaluate the Effect of a Statewide Quality Improvement Program on New Persistent Opioid Use After Surgery[NCT04805229] | 30,000 participants (Actual) | Observational | 2013-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Cumulative opiate consumption (IV morphine equivalents) (NCT02487303)
Timeframe: 24 hours
| Intervention | mg (Mean) |
|---|---|
| Acetaminophen Intravenous | 2.9 |
| Acetaminophen Oral | 3.8 |
| No Acetaminophen | 5.7 |
Time patient meets discharge criteria will be recorded (NCT02487303)
Timeframe: 24 hours postoperative
| Intervention | hours (Mean) |
|---|---|
| Acetaminophen Intravenous | 48.4 |
| Acetaminophen Oral | 48.6 |
| No Acetaminophen | 50.5 |
Time to first opiate pain medicine requested by patient (NCT02487303)
Timeframe: 48 hours
| Intervention | hours (Mean) |
|---|---|
| Acetaminophen Intravenous | 25.3 |
| Acetaminophen Oral | 24.0 |
| No Acetaminophen | 21.3 |
"Visual Analog Scale (VAS) pain assessment with ambulation. The visual analog scale (VAS) is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between no pain and worst pain. For pain intensity, the scale is most commonly anchored by no pain (score of 0) and pain as bad as it could be or worst imaginable pain (score of 100 [100-mm scale]) ." (NCT02487303)
Timeframe: 24 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Acetaminophen Intravenous | 37.8 |
| Acetaminophen Oral | 44.3 |
| No Acetaminophen | 50.8 |
1 review available for acetaminophen and Breakthrough Pain
| Article | Year |
|---|---|
Opioid Use and Misuse in Pregnancy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory A | 2020 |
5 trials available for acetaminophen and Breakthrough Pain
| Article | Year |
|---|---|
The erector spinae plane block can facilitate outpatient stone surgery by reducing breakthrough pain.
Topics: Acetaminophen; Adult; Aged; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Analgesics, Op | 2021 |
Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St | 2018 |
Effectiveness of acetaminophen in control of breakthrough pain: Randomized controlled trial.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Breakthrough Pa | 2018 |
Intravenous vs Oral Acetaminophen for Analgesia After Cesarean Delivery: A Randomized Trial.
Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Adult; Analgesics, Non-Narcotic; A | 2019 |
Efficacy of oxycodone/paracetamol for patients with bone-cancer pain: a multicenter, randomized, double-blinded, placebo-controlled trial.
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Bone Neopla | 2012 |
6 other studies available for acetaminophen and Breakthrough Pain
| Article | Year |
|---|---|
Successful buprenorphine transition while overlapping with a full opioid agonist to treat chronic pain: a case report.
Topics: Acetaminophen; Analgesics, Opioid; Animals; Breakthrough Pain; Buprenorphine; Cattle; Chronic Pain; | 2023 |
How We Do It: Postoperative Pain Control in Mohs Micrographic Surgery.
Topics: Acetaminophen; Aged; Analgesics; Anesthesia, Local; Anesthetics, Local; Breakthrough Pain; Celecoxib | 2021 |
Pain management in patients with end-stage renal disease and calciphylaxis- a survey of clinical practices among physicians.
Topics: Acetaminophen; Advance Care Planning; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesic | 2020 |
Characteristics and Treatment of Breakthrought Pain (BTcP) in Palliative Care.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics, Non-Narcot | 2017 |
Multimodal Postoperative Pain Control Is Effective and Reduces Opioid Use After Laparoscopic Roux-en-Y Gastric Bypass.
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Analgesics, Opioid; Breakthrough Pain; Celecoxib; | 2019 |
Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |
Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |
Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |
Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |
Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |
Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |
Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |
Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |
Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |
Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |
Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |
Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |
Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |
Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |
Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |
Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |