acetaminophen has been researched along with Brain Swelling in 43 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " While dosing errors are common, in most cases, overdoses produce minimal clinical effects." | 5.37 | Massive acetylcysteine overdose associated with cerebral edema and seizures. ( Heard, K; Schaeffer, TH, 2011) |
| "We describe a 36 year old patient with ALF and brain edema from acetaminophen overdose who had an EVD placed for ICP monitoring and management." | 3.77 | Emergent, controlled lumbar drainage for intracranial pressure monitoring during orthotopic liver transplantation. ( Arasi, L; Bacani, CJ; Canabal, JC; Di Trapani, RA; Freeman, WD; Shine, T; Willingham, DL, 2011) |
| "In patients with FHF and cerebral edema from acetaminophen overdose, prolonged therapeutic hypothermia could potentially be used as a life saving therapy and a bridge to hepatic and neurological recovery." | 3.75 | Prolonged hypothermia as a bridge to recovery for cerebral edema and intracranial hypertension associated with fulminant hepatic failure. ( Jacob, S; Jacobs, ER; Kandiah, P; Khan, A; Nanchal, R, 2009) |
| " Prehepatic portal hypertension (group II), acetaminophen intoxication (group III) and both (group IV) had changes in the blood brain-barrier integrity (trypan blue) and hyperammonemia." | 3.72 | Hyperammonemia, brain edema and blood-brain barrier alterations in prehepatic portal hypertensive rats and paracetamol intoxication. ( Castro, JL; Eizayaga, FX; Fernández, MA; Lemberg, A; Perazzo, JC; Prestifilippo, JP; Romay, S; Scorticati, C, 2004) |
| " As the two patients had developed hepatic encephalopathy they were treated with mannitol to reduce intra-cerebral oedema." | 3.72 | Renal transplants from non-heart beating paracetamol overdose donors. ( Bhatti, A; Gok, MA; Gupta, A; Olschewski, P; Robertson, H; Shenton, BK; Soomro, N; Talbot, D, 2004) |
| " Fever always occurred before their admission and aspirin (n = 12) or acetaminophen (n = 7) was prescribed." | 3.71 | [Severe Reye syndrome: report of 14 cases managed in a pediatric intensive care unit over 11 years]. ( Brivet, M; Chevret, L; Debray, D; Devictor, D; Durand, P; Fabre, M; Thabet, F, 2002) |
| "Cerebral edema is a cardinal feature and may produce uncal herniation, yielding brain stem compression and death." | 2.48 | Acute liver failure. ( Lee, WM, 2012) |
| "Acetaminophen is a common cause of acute liver failure in pediatrics." | 1.48 | A case report of full recovery from severe cerebral edema secondary to acetaminophen-induced hepatotoxicity in a 13 year old girl. ( Austin, EB; Crouse, BA; Hobbs, H; Lobos, AT, 2018) |
| "Cerebral edema is a major cause of death during acute liver failure (ALF), but the exact mechanism of this condition is still not entirely clear." | 1.37 | Tumor necrosis factor-α affects blood-brain barrier permeability in acetaminophen-induced acute liver failure. ( Fu, J; Li, C; Liu, P; Lv, S; Wang, W; Zhou, Y, 2011) |
| " While dosing errors are common, in most cases, overdoses produce minimal clinical effects." | 1.37 | Massive acetylcysteine overdose associated with cerebral edema and seizures. ( Heard, K; Schaeffer, TH, 2011) |
| "However, brain swelling and marked clinical and EEG suppression are potentially reversible, even though the same findings are associated with a very poor neurological outcome in anoxic-ischemic encephalopathy." | 1.36 | Recovery of awareness after hyperacute hepatic encephalopathy with "flat" EEG, severe brain edema and deep coma. ( Hunter, GR; Young, GB, 2010) |
| "Fulminant hepatic encephalopathy has a high mortality." | 1.33 | Microdialysis in the management of hepatic encephalopathy. ( Al-Rawi, PG; Czosnyka, M; Gimson, A; Hutchinson, PJ; Menon, DK; O'Connell, MT, 2006) |
| "Cerebral edema is a serious complication of the encephalopathy in fulminant hepatic failure." | 1.28 | Electron microscopic study of brain capillaries in cerebral edema from fulminant hepatic failure. ( Hughes, RD; Kato, M; Keays, RT; Williams, R, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (18.60) | 18.7374 |
| 1990's | 10 (23.26) | 18.2507 |
| 2000's | 13 (30.23) | 29.6817 |
| 2010's | 12 (27.91) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Austin, EB | 1 |
| Hobbs, H | 1 |
| Crouse, BA | 1 |
| Lobos, AT | 1 |
| Rama Rao, KV | 1 |
| Verkman, AS | 1 |
| Curtis, KM | 1 |
| Norenberg, MD | 1 |
| Karvellas, CJ | 1 |
| Todd Stravitz, R | 1 |
| Battenhouse, H | 1 |
| Lee, WM | 2 |
| Schilsky, ML | 1 |
| Carson, HJ | 1 |
| Eilers, SG | 1 |
| Fridman, V | 1 |
| Galetta, SL | 1 |
| Pruitt, AA | 1 |
| Levine, JM | 1 |
| Jacob, S | 1 |
| Khan, A | 1 |
| Jacobs, ER | 1 |
| Kandiah, P | 1 |
| Nanchal, R | 1 |
| Bémeur, C | 1 |
| Vaquero, J | 1 |
| Desjardins, P | 1 |
| Butterworth, RF | 2 |
| Hunter, GR | 1 |
| Young, GB | 1 |
| Ford, RM | 1 |
| Sakaria, SS | 1 |
| Subramanian, RM | 1 |
| Bacani, CJ | 1 |
| Freeman, WD | 1 |
| Di Trapani, RA | 1 |
| Canabal, JC | 1 |
| Arasi, L | 1 |
| Shine, T | 1 |
| Willingham, DL | 1 |
| Wang, W | 1 |
| Lv, S | 1 |
| Zhou, Y | 1 |
| Fu, J | 1 |
| Li, C | 1 |
| Liu, P | 1 |
| Kuo, JR | 1 |
| Lo, CJ | 1 |
| Wang, CC | 1 |
| Lu, CL | 1 |
| Lin, SC | 1 |
| Chen, CF | 1 |
| Heard, K | 1 |
| Schaeffer, TH | 1 |
| McGuire, BM | 1 |
| McCormick, PA | 1 |
| Treanor, D | 1 |
| McCormack, G | 1 |
| Farrell, M | 1 |
| Scorticati, C | 1 |
| Prestifilippo, JP | 1 |
| Eizayaga, FX | 1 |
| Castro, JL | 1 |
| Romay, S | 1 |
| Fernández, MA | 1 |
| Lemberg, A | 1 |
| Perazzo, JC | 1 |
| Gok, MA | 1 |
| Gupta, A | 1 |
| Olschewski, P | 1 |
| Bhatti, A | 1 |
| Shenton, BK | 1 |
| Robertson, H | 1 |
| Soomro, N | 1 |
| Talbot, D | 1 |
| Ganesalam, K | 1 |
| Larsen, FS | 2 |
| Hutchinson, PJ | 1 |
| Gimson, A | 1 |
| Al-Rawi, PG | 1 |
| O'Connell, MT | 1 |
| Czosnyka, M | 1 |
| Menon, DK | 1 |
| Hofmeijer, J | 1 |
| Amelink, GJ | 1 |
| den Hertog, HM | 1 |
| Algra, A | 1 |
| Kappelle, LJ | 1 |
| van der Worp, HB | 1 |
| Levine, S | 1 |
| Casner, N | 1 |
| Compitello, R | 1 |
| Saad, AM | 1 |
| Plakogiannis, FM | 1 |
| Sutherland, LR | 1 |
| Muller, P | 1 |
| Lewis, DR | 1 |
| Makin, AJ | 1 |
| Wendon, J | 2 |
| Williams, R | 7 |
| Ambühl, PM | 1 |
| Ballmer, PE | 1 |
| Krähenbühl, S | 1 |
| Wendon, JA | 1 |
| Harrison, PM | 1 |
| Keays, R | 1 |
| Schiødt, FV | 1 |
| Clemmesen, JO | 1 |
| Hansen, BA | 1 |
| Braunfeld, MY | 1 |
| Bernal, W | 1 |
| Nyberg, SL | 1 |
| Pfeifer, EA | 1 |
| Thabet, F | 1 |
| Durand, P | 1 |
| Chevret, L | 1 |
| Fabre, M | 1 |
| Debray, D | 1 |
| Brivet, M | 1 |
| Devictor, D | 1 |
| Gazzard, BG | 1 |
| Portmann, B | 1 |
| Murray-Lyon, IM | 1 |
| Kato, M | 1 |
| Hughes, RD | 1 |
| Keays, RT | 1 |
| Bray, GP | 1 |
| Mowat, C | 1 |
| Muir, DF | 1 |
| Tredger, JM | 1 |
| Davenport, A | 3 |
| Will, EJ | 3 |
| Davison, AM | 2 |
| Losowsky, MS | 1 |
| Fagan, E | 1 |
| Forbes, A | 1 |
| Maclean, D | 1 |
| Peters, TJ | 1 |
| Brown, RA | 1 |
| McCathie, M | 1 |
| Baines, GF | 1 |
| Robertson, PG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| A Phase 2a Study to Evaluate the Safety and Tolerability of OCR-002 (Ornithine Phenylacetate) in the Treatment of Patients With Acute Liver Failure/Severe Acute Liver Injury[NCT01548690] | Phase 2 | 47 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To evaluate the effect of OCR-002 on ammonia levels in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: Baseline and 72 Hours
| Intervention | Percent Change (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 41.2 |
| Maximum Dose Level 6.65 g/24h | 16.6 |
| Maximum Dose Level 10 g/24h | 41.8 |
| Maximum Dose Level 20g/24h | 38.4 |
To evaluate the steady state pharmacokinetic and pharmacodynamic profile of OCR-002 in patients with impaired and intact renal function using urinary phenylacetylglutamine (PAGN) as a surrogate marker (NCT01548690)
Timeframe: 24 Hours after last infusion
| Intervention | micrograms per millileter (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 65.6 |
| Maximum Dose Level 6.65 g/24h | 32.2 |
| Maximum Dose Level 10 g/24h | 33.4 |
| Maximum Dose Level 20g/24h | 104.9 |
The orientation log focuses on orientation to place, time, and circumstance. There are 10 items on the orientation log, which are scored 0-3. A spontaneous correct response is awarded 3 points. A spontaneous response that is lacking or incorrect, but a correct response is provided following a logical cue is awarded 2 points. A score of 1 is given if spontaneous and cued responses are lacking or incorrect, but a correct response is provided in a recognition format. A score of 0 is given if the spontaneous, cued, or recognition format does not generate a correct answer. Scores from the 10 items are summed and the final score ranges from 0 to 30. (NCT01548690)
Timeframe: 30 Days
| Intervention | units on a scale (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 23.8 |
| Maximum Dose Level 6.65 g/24h | 24.0 |
| Maximum Dose Level 10 g/24h | 24.0 |
| Maximum Dose Level 20g/24h | 24.0 |
The West Haven Criteria (WHC) for Hepatic Encephalopathy measures the severity of encephalopathy and patient's level of consciousness. The scale ranges from 0 to 4; a minimum score of 0 represents a better outcome, and a maximum total score of 4 represents a worse outcome. A score of 0 corresponds to normal consciousness and behavior and normal neurological examination. A score of 1 corresponds to mild lack of awareness, shortened attention span, and impaired addition or subtraction; mild asterixis or tremor. A score of 2 corresponds to lethargy, disorientated or inappropriate behavior, obvious asterixis; slurred speech. A score of 3 corresponds to somnolent but arousable, gross disorientation or bizarre behavior, muscle rigidity and clonus; hyperreflexia. A score of 4 corresponds to coma and decerebrate posturing. (NCT01548690)
Timeframe: 120 hours from start of infusion
| Intervention | units on a scale (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 2.4 |
| Maximum Dose Level 6.65 g/24h | 3.2 |
| Maximum Dose Level 10 g/24h | 1.6 |
| Maximum Dose Level 20g/24h | 1.8 |
To evaluate the safety and tolerability of OCR-002 in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: 30 Days
| Intervention | Participants (Count of Participants) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 0 |
| Maximum Dose Level 6.65 g/24h | 0 |
| Maximum Dose Level 10 g/24h | 0 |
| Maximum Dose Level 20g/24h | 0 |
7 reviews available for acetaminophen and Brain Swelling
| Article | Year |
|---|---|
Critical care management of patients before liver transplantation.
Topics: Acetaminophen; Acetylcysteine; Brain Edema; Drug Overdose; End Stage Liver Disease; Hepatopulmonary | 2010 |
Hepatic encephalopathy: a central neuroinflammatory disorder?
Topics: Acetaminophen; Acetylcysteine; Animals; Brain Edema; Hepatic Encephalopathy; Humans; Hypothermia, In | 2011 |
Acute liver failure.
Topics: Acetaminophen; Brain Edema; Hepatic Encephalopathy; Humans; Liver Failure, Acute; Liver Transplantat | 2012 |
The critically ill liver patient: fulminant hepatic failure.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Brain Edema; Critical Illness; Diagnosis, D | 2003 |
Acute liver failure--current approach to treatment.
Topics: Acetaminophen; Brain Edema; Critical Care; Humans; Intracranial Pressure; Liver Failure, Acute; Live | 2005 |
[Fulminant hepatitis: pathogenesis, clinical aspects and management].
Topics: Acetaminophen; Adult; Brain Edema; Chemical and Drug Induced Liver Injury; Hemorrhage; Hepatic Encep | 1994 |
Acute liver failure; clinical features and management.
Topics: Acetaminophen; Brain Edema; Diuretics, Osmotic; Hepatitis, Viral, Human; Humans; Liver Failure, Acut | 1999 |
2 trials available for acetaminophen and Brain Swelling
| Article | Year |
|---|---|
Appreciation of the informed consent procedure in a randomised trial of decompressive surgery for space occupying hemispheric infarction.
Topics: Acetaminophen; Aged; Brain Edema; Health Knowledge, Attitudes, Practice; Humans; Infarction, Middle | 2007 |
Continuous vs. intermittent forms of haemofiltration and/or dialysis in the management of acute renal failure in patients with defective cerebral autoregulation at risk of cerebral oedema.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Brain Edema; Female; Hemodynamics; Hemofiltration; Hepati | 1991 |
34 other studies available for acetaminophen and Brain Swelling
| Article | Year |
|---|---|
A case report of full recovery from severe cerebral edema secondary to acetaminophen-induced hepatotoxicity in a 13 year old girl.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Brain; Brain Edema; Critical Care; Drug Overdos | 2018 |
Aquaporin-4 deletion in mice reduces encephalopathy and brain edema in experimental acute liver failure.
Topics: Acetaminophen; Analysis of Variance; Animals; Aquaporin 4; Brain Diseases; Brain Edema; Disease Mode | 2014 |
Therapeutic hypothermia in acute liver failure: a multicenter retrospective cohort analysis.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Edema; Chemical and Drug Induced Liver Injury; | 2015 |
Death from undiagnosed glioblastoma multiforme and toxic self-medication presenting with concurrent dysfunctional behavior.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Brain Edema; Brain Neoplasms; Dextropro | 2008 |
MRI findings associated with acute liver failure.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain; Brain Edema; Coma; Diphenhydramine; Hepatic E | 2009 |
Prolonged hypothermia as a bridge to recovery for cerebral edema and intracranial hypertension associated with fulminant hepatic failure.
Topics: Acetaminophen; Adult; Brain; Brain Edema; Female; Humans; Hypothermia; Hypothermia, Induced; Intracr | 2009 |
N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms.
Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Azoxymethane; Brain Edema; Carcinogens; Cytoki | 2010 |
Recovery of awareness after hyperacute hepatic encephalopathy with "flat" EEG, severe brain edema and deep coma.
Topics: Acetaminophen; Adult; Awareness; Brain Edema; Electroencephalography; Hepatic Encephalopathy; Hepati | 2010 |
Emergent, controlled lumbar drainage for intracranial pressure monitoring during orthotopic liver transplantation.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Edema; Drainage; Drug Overdose; Female; Follow | 2011 |
Tumor necrosis factor-α affects blood-brain barrier permeability in acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antibodies, Neutralizing; Blood-Brain Barrier; Bra | 2011 |
Measuring brain temperature while maintaining brain normothermia in patients with severe traumatic brain injury.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Body Temperatur | 2011 |
Massive acetylcysteine overdose associated with cerebral edema and seizures.
Topics: Acetaminophen; Acetylcysteine; Adult; Brain Edema; Drug Overdose; Female; Humans; Medication Errors; | 2011 |
Early death from paracetamol (acetaminophen) induced fulminant hepatic failure without cerebral oedema.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Edema; Cardiovascular Diseases; Cause of Death | 2003 |
Hyperammonemia, brain edema and blood-brain barrier alterations in prehepatic portal hypertensive rats and paracetamol intoxication.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Blood-Brain Barrier; Brain Edema | 2004 |
Renal transplants from non-heart beating paracetamol overdose donors.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Edema; Cryopreservation; Diuretics, Osmotic; D | 2004 |
Is it worthwhile to use cerebral microdialysis in patients with acute liver failure?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Bra | 2006 |
Microdialysis in the management of hepatic encephalopathy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Glucose; Brain; Brain Edema; Critical Care; Dextropro | 2006 |
Reduction of inflammatory brain edema by nonsteroidal antiinflammatory drugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Benzoxazoles; Brain; Brain Edema; Copper; Dexameth | 1981 |
Massive cerebral edema associated with fulminant hepatic failure in acetaminophen overdose: possible role of cranial decompression.
Topics: Acetaminophen; Adolescent; Brain Edema; Chemical and Drug Induced Liver Injury; Female; Humans; Live | 1981 |
A 7-year experience of severe acetaminophen-induced hepatotoxicity (1987-1993).
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Brain Edema; Chi-S | 1995 |
Cerebral blood flow and metabolism in fulminant liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Blood Flow Velocity; Brain; Brain Edema; Drug Overdose; Epopro | 1994 |
Cerebral edema due to hemodialysis in paracetamol-induced fulminant hepatic failure.
Topics: Acetaminophen; Adult; Brain Edema; Fatal Outcome; Female; Hepatic Encephalopathy; Humans; Male; Rena | 1995 |
Case presentation: fulminant hepatic failure.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Death; Brain Edema; Female; Hepatic Encephalop | 1999 |
Cerebral edema with herniation during acetaminophen-induced fulminant hepatic failure.
Topics: Acetaminophen; Adult; Anticonvulsants; Brain; Brain Edema; Drug Synergism; Encephalocele; Fatal Outc | 2000 |
[Severe Reye syndrome: report of 14 cases managed in a pediatric intensive care unit over 11 years].
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Edema; Child; Child, Preschoo | 2002 |
Causes of death in fulminant hepatic failure and relationship to quantitative histological assessment of parenchymal damage.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Amanita; Autopsy; Brain Edema; Drug Hypersensit | 1975 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 23--1977.
Topics: Acetaminophen; Acute Disease; Adolescent; Arthritis, Juvenile; Aspirin; Brain Death; Brain Edema; Ch | 1977 |
Electron microscopic study of brain capillaries in cerebral edema from fulminant hepatic failure.
Topics: Acetaminophen; Adolescent; Adult; Astrocytes; Basement Membrane; Blood-Brain Barrier; Brain; Brain E | 1992 |
The effect of chronic alcohol intake on prognosis and outcome in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Alcoholism; Aspartate Aminotransferases; Brain Edema; Chemical | 1991 |
Effect of posture on intracranial pressure and cerebral perfusion pressure in patients with fulminant hepatic and renal failure after acetaminophen self-poisoning.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Blood Pressure; Brain Edema; Cerebrovascular Circulation; | 1990 |
Rebound surges of intracranial pressure as a consequence of forced ultrafiltration used to control intracranial pressure in patients with severe hepatorenal failure.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Brain Edema; Drug Overdose; Female; Hemofiltration; Hepat | 1989 |
Toxic myocarditis in paracetamol poisoning.
Topics: Acetaminophen; Brain Edema; Humans; Myocarditis | 1988 |
Treatment of acute paracetamol poisoning.
Topics: Acetaminophen; Adult; Blood Protein Disorders; Brain Edema; Chemical and Drug Induced Liver Injury; | 1968 |
Hepatic encephalopathy.
Topics: Acetaminophen; Ammonia; Animals; Brain; Brain Edema; Diet Therapy; Dopamine; Female; Humans; Lactulo | 1973 |