acetaminophen has been researched along with Brain Ischemia in 18 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2) was a multicenter, randomized, double-blind, placebo-controlled clinical trial." | 9.24 | PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial. ( Algra, A; de Ridder, IR; den Hertog, HM; Dippel, DW; Jansen, BP; Kappelle, LJ; Koudstaal, PJ; Maasland, EL; Ruitenberg, A; Saxena, R; Schreuder, AH; Van den Berg-Vos, RM; van der Worp, HB; van Gemert, HM; van Tuijl, JH; Vermeij, F, 2017) |
| "In the majority of patients with acute ischemic stroke, ASA and acetaminophen are insufficient for reducing an elevated BT to a state of normothermia." | 9.11 | Acetylsalicylic acid and acetaminophen to combat elevated body temperature in acute ischemic stroke. ( De Keyser, J; Elting, JW; Luijckx, GJ; Luyckx, GJ; Maurits, N; Sulter, G, 2004) |
| "The authors assessed the time of onset of the hypothermic effect of acetaminophen in 102 patients with acute ischemic stroke." | 9.10 | Timing of the effect of acetaminophen on body temperature in patients with acute ischemic stroke. ( Algra, A; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2003) |
| "Seventy-five patients with acute ischemic stroke confined to the anterior circulation were randomized to treatment with either 500 mg (low dose) or 1000 mg (high dose) acetaminophen or with placebo, administered as suppositories 6 times daily during 5 days." | 9.09 | Effect of paracetamol (acetaminophen) on body temperature in acute ischemic stroke: a double-blind, randomized phase II clinical trial. ( Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Meijer, RJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2001) |
| " We determined whether paracetamol or ibuprofen use is associated with major cardiovascular events (MACE) or major bleeding in 19 120 patients with recent ischemic stroke or transient ischemic attack of mainly atherothrombotic origin included in the Prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) trial." | 7.83 | Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke. ( Amarenco, P; Bousser, MG; Chamorro, A; Fisher, M; Ford, I; Fox, KM; Gonzalez-Valcarcel, J; Hennerici, MG; Labreuche, J; Mattle, HP; Rothwell, PM; Sissani, L; Steg, PG; Vicaut, E, 2016) |
| " Acetaminophen has been tried in stroke patients to produce hypothermia so that injury following cerebral ischemia can be reduced." | 7.76 | Endothelin-A receptor antagonist BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral ischemia in rats. ( Briyal, S; Gulati, A, 2010) |
| "PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2) was a multicenter, randomized, double-blind, placebo-controlled clinical trial." | 5.24 | PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial. ( Algra, A; de Ridder, IR; den Hertog, HM; Dippel, DW; Jansen, BP; Kappelle, LJ; Koudstaal, PJ; Maasland, EL; Ruitenberg, A; Saxena, R; Schreuder, AH; Van den Berg-Vos, RM; van der Worp, HB; van Gemert, HM; van Tuijl, JH; Vermeij, F, 2017) |
| "In the majority of patients with acute ischemic stroke, ASA and acetaminophen are insufficient for reducing an elevated BT to a state of normothermia." | 5.11 | Acetylsalicylic acid and acetaminophen to combat elevated body temperature in acute ischemic stroke. ( De Keyser, J; Elting, JW; Luijckx, GJ; Luyckx, GJ; Maurits, N; Sulter, G, 2004) |
| "The authors assessed the time of onset of the hypothermic effect of acetaminophen in 102 patients with acute ischemic stroke." | 5.10 | Timing of the effect of acetaminophen on body temperature in patients with acute ischemic stroke. ( Algra, A; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2003) |
| "Seventy-five patients with acute ischemic stroke confined to the anterior circulation were randomized to treatment with either 500 mg (low dose) or 1000 mg (high dose) acetaminophen or with placebo, administered as suppositories 6 times daily during 5 days." | 5.09 | Effect of paracetamol (acetaminophen) on body temperature in acute ischemic stroke: a double-blind, randomized phase II clinical trial. ( Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Meijer, RJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2001) |
| " We determined whether paracetamol or ibuprofen use is associated with major cardiovascular events (MACE) or major bleeding in 19 120 patients with recent ischemic stroke or transient ischemic attack of mainly atherothrombotic origin included in the Prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) trial." | 3.83 | Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke. ( Amarenco, P; Bousser, MG; Chamorro, A; Fisher, M; Ford, I; Fox, KM; Gonzalez-Valcarcel, J; Hennerici, MG; Labreuche, J; Mattle, HP; Rothwell, PM; Sissani, L; Steg, PG; Vicaut, E, 2016) |
| " Acetaminophen has been tried in stroke patients to produce hypothermia so that injury following cerebral ischemia can be reduced." | 3.76 | Endothelin-A receptor antagonist BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral ischemia in rats. ( Briyal, S; Gulati, A, 2010) |
| "Spontaneous aneurysmal subarachnoid hemorrhage (aSAH) recovery may be hampered by delayed cerebral ischemia (DCI)." | 1.91 | Evaluating analgesic medications utilized in the treatment of aneurysmal subarachnoid hemorrhage and association with delayed cerebral ischemia. ( Busl, KM; Desai, A; Eisinger, RS; Lucke-Wold, B; Maciel, CB; Sorrentino, ZA, 2023) |
| "When post-ischemic seizures ensued in hyperglycemic subjects, temperature was 39." | 1.29 | Preischemic hyperglycemia leads to delayed postischemic hyperthermia. ( Lundgren, J; Siesjö, BK; Smith, ML; Uchino, H, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 9 (50.00) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Sorrentino, ZA | 1 |
| Desai, A | 1 |
| Eisinger, RS | 1 |
| Maciel, CB | 1 |
| Busl, KM | 1 |
| Lucke-Wold, B | 1 |
| Frank, B | 1 |
| Fulton, RL | 1 |
| Weimar, C | 1 |
| Lees, KR | 1 |
| Sanders, RD | 1 |
| de Ridder, I | 1 |
| den Hertog, H | 1 |
| van Gemert, M | 1 |
| Dippel, D | 1 |
| van der Worp, B | 1 |
| García-Poza, P | 1 |
| de Abajo, FJ | 1 |
| Gil, MJ | 1 |
| Chacón, A | 1 |
| Bryant, V | 1 |
| García-Rodríguez, LA | 1 |
| Gonzalez-Valcarcel, J | 1 |
| Sissani, L | 1 |
| Labreuche, J | 1 |
| Bousser, MG | 1 |
| Chamorro, A | 1 |
| Fisher, M | 1 |
| Ford, I | 1 |
| Fox, KM | 1 |
| Hennerici, MG | 1 |
| Mattle, HP | 1 |
| Rothwell, PM | 1 |
| Steg, PG | 1 |
| Vicaut, E | 1 |
| Amarenco, P | 1 |
| Iannuccelli, C | 1 |
| Di Franco, M | 1 |
| Pulcinelli, FM | 1 |
| de Ridder, IR | 1 |
| den Hertog, HM | 2 |
| van Gemert, HM | 4 |
| Schreuder, AH | 1 |
| Ruitenberg, A | 1 |
| Maasland, EL | 1 |
| Saxena, R | 1 |
| van Tuijl, JH | 1 |
| Jansen, BP | 1 |
| Van den Berg-Vos, RM | 1 |
| Vermeij, F | 1 |
| Koudstaal, PJ | 4 |
| Kappelle, LJ | 4 |
| Algra, A | 3 |
| van der Worp, HB | 4 |
| Dippel, DW | 4 |
| van Gijn, J | 1 |
| Baliga, SS | 2 |
| Jaques-Robinson, KM | 1 |
| Hadzimichalis, NM | 1 |
| Golfetti, R | 1 |
| Merrill, GF | 2 |
| Briyal, S | 1 |
| Gulati, A | 1 |
| Shinohara, ML | 1 |
| Denhardt, DT | 1 |
| van Breda, EJ | 2 |
| Sulter, G | 1 |
| Elting, JW | 1 |
| Maurits, N | 1 |
| Luijckx, GJ | 1 |
| Luyckx, GJ | 1 |
| De Keyser, J | 1 |
| Wong, AA | 1 |
| Davis, JP | 1 |
| Schluter, PJ | 1 |
| Henderson, RD | 1 |
| O'Sullivan, JD | 1 |
| Read, SJ | 1 |
| Uchino, H | 1 |
| Lundgren, J | 1 |
| Smith, ML | 1 |
| Siesjö, BK | 1 |
| Mehsen, M | 1 |
| Liguoro, D | 1 |
| Besse, JL | 1 |
| Marguinaud, E | 1 |
| Crozat, P | 1 |
| Ravussin, P | 1 |
| Boulard, G | 1 |
| Meijer, RJ | 1 |
| Koennecke, HC | 1 |
| Leistner, S | 1 |
7 trials available for acetaminophen and Brain Ischemia
| Article | Year |
|---|---|
Increased benefit of alteplase in patients with ischemic stroke and a high body temperature.
Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Body Temperature; Brain Ischemia; Double-Blind | 2013 |
PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial.
Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Brain Ischemia; Cerebral Hemorrhage; Double-Bl | 2017 |
The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Brain Ischemia; Fema | 2009 |
Timing of the effect of acetaminophen on body temperature in patients with acute ischemic stroke.
Topics: Acetaminophen; Acute Disease; Aged; Body Temperature; Brain Ischemia; Double-Blind Method; Female; H | 2003 |
Acetylsalicylic acid and acetaminophen to combat elevated body temperature in acute ischemic stroke.
Topics: Acetaminophen; Acute Disease; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroida | 2004 |
Effect of paracetamol (acetaminophen) on body temperature in acute ischemic stroke: a double-blind, randomized phase II clinical trial.
Topics: Acetaminophen; Acute Disease; Aged; Body Temperature; Brain Ischemia; Double-Blind Method; Female; F | 2001 |
Prophylactic antipyretic treatment with acetaminophen in acute ischemic stroke: a pilot study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Ischemia; Double-Blind Method; Female; Humans; | 2001 |
11 other studies available for acetaminophen and Brain Ischemia
| Article | Year |
|---|---|
Evaluating analgesic medications utilized in the treatment of aneurysmal subarachnoid hemorrhage and association with delayed cerebral ischemia.
Topics: Acetaminophen; Aged; Analgesics; Brain Ischemia; Cerebral Infarction; Female; Humans; Male; Middle A | 2023 |
Use of paracetamol in ischaemic stroke patients: evidence from VISTA.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Brain Ischemia; Female; Fever; Hum | 2013 |
Risk of ischemic stroke associated with non-steroidal anti-inflammatory drugs and paracetamol: a population-based case-control study.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischem | 2015 |
Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Brain Ischemia; Cardiovascular Diseases; Female; Hemo | 2016 |
Letter by Iannuccelli et al Regarding Article, "Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke".
Topics: Acetaminophen; Brain Ischemia; Hemorrhage; Humans; Ibuprofen; Stroke | 2016 |
Acetaminophen reduces mitochondrial dysfunction during early cerebral postischemic reperfusion in rats.
Topics: Acetaminophen; Animals; Apoptosis; Brain; Brain Ischemia; Carotid Artery Diseases; Caspase 9; Cytoch | 2010 |
Endothelin-A receptor antagonist BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral ischemia in rats.
Topics: Acetaminophen; Animals; Antipyretics; Brain Ischemia; Disease Models, Animal; Drug Synergism; Endoth | 2010 |
Osteopontin expression during early cerebral ischemia-reperfusion in rats: enhanced expression in the right cortex is suppressed by acetaminophen.
Topics: Acetaminophen; Animals; Brain Ischemia; Cerebral Cortex; Gene Expression; Osteopontin; Rats; Reperfu | 2011 |
The time course and determinants of temperature within the first 48 h after ischaemic stroke.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Bacterial Infec | 2007 |
Preischemic hyperglycemia leads to delayed postischemic hyperthermia.
Topics: Acetaminophen; Animals; Body Temperature Regulation; Brain Ischemia; Fever; Glucose; Hypercapnia; Hy | 1994 |
[Pre- and postoperative management of early aneurysm surgery].
Topics: Acetaminophen; Adult; Aged; Brain Ischemia; Calcium Channel Blockers; Cerebrospinal Fluid Shunts; Cl | 1993 |