Page last updated: 2024-10-22

acetaminophen and Brain Hemorrhage

acetaminophen has been researched along with Brain Hemorrhage in 4 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carson, HJ1
Eilers, SG1
den Hertog, HM1
van der Worp, HB1
van Gemert, HM1
Algra, A1
Kappelle, LJ1
van Gijn, J1
Koudstaal, PJ1
Dippel, DW1
Mullins, ME1
Empey, M1
Jaramillo, D1
Sosa, S1
Human, T1
Diringer, MN1
Badjatia, N1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prospective Comparative Study of the Efficacy of Common Antipyretic Treatments in Febrile Children[NCT02294071]Phase 4120 participants (Anticipated)Interventional2014-12-31Not yet recruiting
Efficacy of Bromocriptine to Reduce Body Temperature in Febrile Critically-ill Adults With Acute Neurologic Disease: an Open-label, Blinded Endpoint, Randomized Controlled Trial[NCT03496545]Phase 1/Phase 247 participants (Actual)Interventional2018-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Temperature Burden

Mean total body temperature burden above 37°C over 48 hours during which patient receives either control or intervention medication. (NCT03496545)
Timeframe: over 48 hours

InterventionTemperature in degrees Celsius (Mean)
Acetaminophen37.8
Bromocriptine and Acetaminophen37.7

Total Time That Temperature is ≥ 38.3ºC

Time in minutes where the temperature is ≥ 38.3ºC during the 48 hours of control versus intervention administration. (NCT03496545)
Timeframe: 48 hours

InterventionMinutes (Mean)
Acetaminophen216
Bromocriptine and Acetaminophen300

Total Time to First Temperature < 37.5ºC

Time in minutes it took after medication administration for the temperature to reach < 37.5ºC. (NCT03496545)
Timeframe: 48 hours

InterventionMinutes (Mean)
Acetaminophen253.5
Bromocriptine and Acetaminophen556

Incidence of Adverse Events - Symptomatic Hypotension, Nausea and Headache

Episodes of symptomatic hypotension, including decrease in supine systolic and diastolic pressures of greater than 20mm and 10mm Hg respectively with patient reported accompanying symptoms of light headedness or dizziness and incidence of nausea and headache. (NCT03496545)
Timeframe: Nursing assessment at every shift during 48 hour study period after first drug administration

,
InterventionParticipants (Count of Participants)
Decrease in blood pressureNauseaHeadache
Acetaminophen1228
Bromocriptine and Acetaminophen17312

Trials

2 trials available for acetaminophen and Brain Hemorrhage

ArticleYear
The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial.
    The Lancet. Neurology, 2009, Volume: 8, Issue:5

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Brain Ischemia; Fema

2009
A prospective randomized study to evaluate the antipyretic effect of the combination of acetaminophen and ibuprofen in neurological ICU patients.
    Neurocritical care, 2011, Volume: 15, Issue:3

    Topics: Academic Medical Centers; Acetaminophen; Antipyretics; Body Temperature; Drug Therapy, Combination;

2011
A prospective randomized study to evaluate the antipyretic effect of the combination of acetaminophen and ibuprofen in neurological ICU patients.
    Neurocritical care, 2011, Volume: 15, Issue:3

    Topics: Academic Medical Centers; Acetaminophen; Antipyretics; Body Temperature; Drug Therapy, Combination;

2011
A prospective randomized study to evaluate the antipyretic effect of the combination of acetaminophen and ibuprofen in neurological ICU patients.
    Neurocritical care, 2011, Volume: 15, Issue:3

    Topics: Academic Medical Centers; Acetaminophen; Antipyretics; Body Temperature; Drug Therapy, Combination;

2011
A prospective randomized study to evaluate the antipyretic effect of the combination of acetaminophen and ibuprofen in neurological ICU patients.
    Neurocritical care, 2011, Volume: 15, Issue:3

    Topics: Academic Medical Centers; Acetaminophen; Antipyretics; Body Temperature; Drug Therapy, Combination;

2011

Other Studies

2 other studies available for acetaminophen and Brain Hemorrhage

ArticleYear
Death from undiagnosed glioblastoma multiforme and toxic self-medication presenting with concurrent dysfunctional behavior.
    Journal of forensic and legal medicine, 2008, Volume: 15, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Brain Edema; Brain Neoplasms; Dextropro

2008
Fever control in the NICU: is there still a simpler and cheaper solution?
    Neurocritical care, 2011, Volume: 15, Issue:3

    Topics: Acetaminophen; Antipyretics; Fever; Humans; Ibuprofen; Intensive Care Units; Intracranial Hemorrhage

2011