acetaminophen has been researched along with Brain Hemorrhage, Cerebral in 18 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2) was a multicenter, randomized, double-blind, placebo-controlled clinical trial." | 9.24 | PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial. ( Algra, A; de Ridder, IR; den Hertog, HM; Dippel, DW; Jansen, BP; Kappelle, LJ; Koudstaal, PJ; Maasland, EL; Ruitenberg, A; Saxena, R; Schreuder, AH; Van den Berg-Vos, RM; van der Worp, HB; van Gemert, HM; van Tuijl, JH; Vermeij, F, 2017) |
| "A 45 year old female with no stroke risk factors suffered a massive intracerebral hemorrhage (ICH) after ingesting Midrin--a combination of isometheptene mucate, dichlorophenazine and acetaminophen." | 7.75 | Life threatening intracerebral hemorrhage with isometheptene mucate, dichlorophenazine and acetaminophen combination therapy. ( Johnston, JC, 2009) |
| " We are uncertain whether tramadol reduces mortality compared to placebo; none of the studies reported pain scores, major neurodevelopmental disability, cognitive and educational outcomes in children older than five years old, retinopathy of prematurity, or intraventricular hemorrhage." | 5.41 | Systemic opioids versus other analgesics and sedatives for postoperative pain in neonates. ( Borges do Nascimento, IJ; Bruschettini, M; Kinoshita, M; Stempel, KS, 2023) |
| "PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2) was a multicenter, randomized, double-blind, placebo-controlled clinical trial." | 5.24 | PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial. ( Algra, A; de Ridder, IR; den Hertog, HM; Dippel, DW; Jansen, BP; Kappelle, LJ; Koudstaal, PJ; Maasland, EL; Ruitenberg, A; Saxena, R; Schreuder, AH; Van den Berg-Vos, RM; van der Worp, HB; van Gemert, HM; van Tuijl, JH; Vermeij, F, 2017) |
| " Patients with aneurysmal subarachnoid hemorrhage (SAH) were randomized to receive either ketoprofen, 100 mg, three times a day (ketoprofen group, n = 9) or a weak NSAID, acetaminophen, 1 g, three times a day (acetaminophen group, n = 9) starting immediately after the diagnosis of aneurysmal SAH." | 5.09 | Effects of nonsteroidal anti-inflammatory drugs on hemostasis in patients with aneurysmal subarachnoid hemorrhage. ( Juvela, S; Niemi, T; Randell, T; Rosenberg, P; Tanskanen, P; Taxell, C, 1999) |
| "A high dose of oral ibuprofen was associated with a higher likelihood of hemodynamically significant PDA closure vs standard doses of intravenous ibuprofen or intravenous indomethacin; placebo or no treatment did not significantly change the likelihood of mortality, necrotizing enterocolitis, or intraventricular hemorrhage." | 4.98 | Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis. ( Florez, ID; Mbuagbaw, L; Mitra, S; Sadeghirad, B; Tamayo, ME; Thabane, L; Vanniyasingam, T; Veroniki, AA; Zea, AM; Zhang, Y, 2018) |
| "A 45 year old female with no stroke risk factors suffered a massive intracerebral hemorrhage (ICH) after ingesting Midrin--a combination of isometheptene mucate, dichlorophenazine and acetaminophen." | 3.75 | Life threatening intracerebral hemorrhage with isometheptene mucate, dichlorophenazine and acetaminophen combination therapy. ( Johnston, JC, 2009) |
| "This is the third case reported of maternal acetaminophen overdose during pregnancy." | 3.68 | Can acetaminophen excess result in maternal and fetal toxicity? ( Kurzel, RB, 1990) |
| " On day 2 post partum, mothers were questioned regarding maternal risk factors, including the use of either aspirin or acetaminophen during the last week of pregnancy." | 3.66 | Neonatal intracranial hemorrhage and maternal use of aspirin. ( Braithwaite, WR; Guggenheim, MA; Johnson, ML; Peterson, RG; Rumack, BH; Rumack, CM, 1981) |
| "Severe infarcts and intracerebral hemorrhages caused temperature to rise, whereas initially increased temperature had no influence on stroke severity." | 2.70 | Stroke severity determines body temperature in acute stroke. ( Boysen, G; Christensen, H, 2001) |
| " No protocol-related adverse events occurred." | 1.51 | Feasibility and Safety of Transnasal High Flow Air to Reduce Core Body Temperature in Febrile Neurocritical Care Patients: A Pilot Study. ( Assis, FR; Geocadin, RG; Shah, D; Tandri, H; Ziai, WC, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 5 (27.78) | 2.80 |
| Authors | Studies |
|---|---|
| Kinoshita, M | 1 |
| Stempel, KS | 1 |
| Borges do Nascimento, IJ | 1 |
| Bruschettini, M | 2 |
| Mitra, S | 2 |
| Hatfield, T | 1 |
| Campbell-Yeo, M | 1 |
| Dorling, J | 1 |
| Johnston, BC | 1 |
| Bai, C | 1 |
| Meng, F | 1 |
| Wu, H | 1 |
| Wu, W | 1 |
| Stróżyk, A | 1 |
| Paraskevas, T | 1 |
| Romantsik, O | 1 |
| Calevo, MG | 1 |
| Banzi, R | 1 |
| Ley, D | 1 |
| Hervella, P | 1 |
| Rodríguez-Yáñez, M | 1 |
| Pumar, JM | 1 |
| Ávila-Gómez, P | 1 |
| da Silva-Candal, A | 1 |
| López-Loureiro, I | 1 |
| Rodríguez-Maqueda, E | 1 |
| Correa-Paz, C | 1 |
| Castillo, J | 1 |
| Sobrino, T | 1 |
| Campos, F | 1 |
| Iglesias-Rey, R | 1 |
| Florez, ID | 1 |
| Tamayo, ME | 1 |
| Mbuagbaw, L | 1 |
| Vanniyasingam, T | 1 |
| Veroniki, AA | 1 |
| Zea, AM | 1 |
| Zhang, Y | 1 |
| Sadeghirad, B | 1 |
| Thabane, L | 1 |
| Raza, SA | 1 |
| Durm, LB | 1 |
| Mahmoud, GA | 1 |
| Rahman, H | 1 |
| Henriquez, L | 1 |
| Davis, B | 1 |
| Nahab, F | 1 |
| Ziai, WC | 1 |
| Shah, D | 1 |
| Assis, FR | 1 |
| Tandri, H | 1 |
| Geocadin, RG | 1 |
| Naver, SV | 1 |
| Papina, M | 1 |
| Solem, EJ | 1 |
| Dalhoff, KP | 1 |
| Tofé Valera, I | 1 |
| Jaraba Caballero, MP | 1 |
| Ruiz González, MD | 1 |
| Rodríguez Benítez, MV | 1 |
| Parraga Quiles, MJ | 1 |
| de Ridder, IR | 1 |
| den Hertog, HM | 1 |
| van Gemert, HM | 1 |
| Schreuder, AH | 1 |
| Ruitenberg, A | 1 |
| Maasland, EL | 1 |
| Saxena, R | 1 |
| van Tuijl, JH | 1 |
| Jansen, BP | 1 |
| Van den Berg-Vos, RM | 1 |
| Vermeij, F | 1 |
| Koudstaal, PJ | 1 |
| Kappelle, LJ | 1 |
| Algra, A | 1 |
| van der Worp, HB | 1 |
| Dippel, DW | 1 |
| Johnston, JC | 1 |
| Shrikanth, V | 1 |
| Vanderheiden, A | 1 |
| Simha, V | 1 |
| Fernandez, A | 1 |
| Schmidt, JM | 1 |
| Claassen, J | 1 |
| Pavlicova, M | 1 |
| Huddleston, D | 1 |
| Kreiter, KT | 1 |
| Ostapkovich, ND | 1 |
| Kowalski, RG | 1 |
| Parra, A | 1 |
| Connolly, ES | 1 |
| Mayer, SA | 1 |
| Rumack, CM | 1 |
| Guggenheim, MA | 1 |
| Rumack, BH | 1 |
| Peterson, RG | 1 |
| Johnson, ML | 1 |
| Braithwaite, WR | 1 |
| Niemi, T | 1 |
| Tanskanen, P | 1 |
| Taxell, C | 1 |
| Juvela, S | 1 |
| Randell, T | 1 |
| Rosenberg, P | 1 |
| Boysen, G | 1 |
| Christensen, H | 1 |
| Kurzel, RB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Bromocriptine to Reduce Body Temperature in Febrile Critically-ill Adults With Acute Neurologic Disease: an Open-label, Blinded Endpoint, Randomized Controlled Trial[NCT03496545] | Phase 1/Phase 2 | 47 participants (Actual) | Interventional | 2018-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Mean total body temperature burden above 37°C over 48 hours during which patient receives either control or intervention medication. (NCT03496545)
Timeframe: over 48 hours
| Intervention | Temperature in degrees Celsius (Mean) |
|---|---|
| Acetaminophen | 37.8 |
| Bromocriptine and Acetaminophen | 37.7 |
Time in minutes where the temperature is ≥ 38.3ºC during the 48 hours of control versus intervention administration. (NCT03496545)
Timeframe: 48 hours
| Intervention | Minutes (Mean) |
|---|---|
| Acetaminophen | 216 |
| Bromocriptine and Acetaminophen | 300 |
Time in minutes it took after medication administration for the temperature to reach < 37.5ºC. (NCT03496545)
Timeframe: 48 hours
| Intervention | Minutes (Mean) |
|---|---|
| Acetaminophen | 253.5 |
| Bromocriptine and Acetaminophen | 556 |
Episodes of symptomatic hypotension, including decrease in supine systolic and diastolic pressures of greater than 20mm and 10mm Hg respectively with patient reported accompanying symptoms of light headedness or dizziness and incidence of nausea and headache. (NCT03496545)
Timeframe: Nursing assessment at every shift during 48 hour study period after first drug administration
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Decrease in blood pressure | Nausea | Headache | |
| Acetaminophen | 12 | 2 | 8 |
| Bromocriptine and Acetaminophen | 17 | 3 | 12 |
3 reviews available for acetaminophen and Brain Hemorrhage, Cerebral
| Article | Year |
|---|---|
Systemic opioids versus other analgesics and sedatives for postoperative pain in neonates.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Cerebral Hemorrhage; Child; Child, Preschool; Fentany | 2023 |
Pharmacological pain and sedation interventions for the prevention of intraventricular hemorrhage in preterm infants on assisted ventilation - an overview of systematic reviews.
Topics: Acetaminophen; Analgesics, Opioid; Cerebral Hemorrhage; Female; Heroin; Humans; Ibuprofen; Infant, N | 2023 |
Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis.
Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Bayes Theorem; Cerebral Hemorrhage | 2018 |
4 trials available for acetaminophen and Brain Hemorrhage, Cerebral
| Article | Year |
|---|---|
Effect of fetal lung maturation on the efficacy of acetaminophen for premature infants with patent ductus arteriosus.
Topics: Acetaminophen; Bronchopulmonary Dysplasia; Cerebral Hemorrhage; Ductus Arteriosus, Patent; Enterocol | 2023 |
PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial.
Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Brain Ischemia; Cerebral Hemorrhage; Double-Bl | 2017 |
Effects of nonsteroidal anti-inflammatory drugs on hemostasis in patients with aneurysmal subarachnoid hemorrhage.
Topics: Acetaminophen; Adenosine Diphosphate; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antithrombin I | 1999 |
Stroke severity determines body temperature in acute stroke.
Topics: Acetaminophen; Acute Disease; Aged; Aged, 80 and over; Anticoagulants; Body Temperature; Cerebral He | 2001 |
11 other studies available for acetaminophen and Brain Hemorrhage, Cerebral
| Article | Year |
|---|---|
Evaluation of Health-Related Values and Preferences of Adults Who Were Preterm Infants and Parents of Preterm Infants Concerning Use of Prophylactic Cyclooxygenase Inhibitor Drugs.
Topics: Acetaminophen; Adult; Cerebral Hemorrhage; Child; Cross-Sectional Studies; Cyclooxygenase Inhibitors | 2023 |
Antihyperthermic treatment decreases perihematomal hypodensity.
Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Body Temperature; Cerebral Hemorrhage; Dipyron | 2020 |
Over-the-counter analgesic powder use in patients presenting with intracerebral hemorrhage: A case series.
Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Black or African American; Cerebral Hemorrhage; Dos | 2018 |
Feasibility and Safety of Transnasal High Flow Air to Reduce Core Body Temperature in Febrile Neurocritical Care Patients: A Pilot Study.
Topics: Acetaminophen; Adult; Aged; Antipyretics; Body Temperature; Cerebral Hemorrhage; Cerebral Intraventr | 2019 |
[Fatal intracerebral haemorrhage possibly caused by interaction between paracetamol and warfarin].
Topics: Acetaminophen; Aged, 80 and over; Analgesics, Non-Narcotic; Anticoagulants; Cerebral Hemorrhage; Dru | 2015 |
The Role of Paracetamol for Closing Patent Ductus Arteriosus. A Challenging Alternative for Ductal Closure?
Topics: Acetaminophen; Administration, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Hemorr | 2016 |
Life threatening intracerebral hemorrhage with isometheptene mucate, dichlorophenazine and acetaminophen combination therapy.
Topics: Acetaminophen; Analgesics; Antipyrine; Cerebral Hemorrhage; Chloral Hydrate; Drug Combinations; Fema | 2009 |
Spontaneous intracerebral hemorrhage associated with ingestion of isometheptine containing anti-migraine medication.
Topics: Acetaminophen; Adult; Antipyrine; Cerebral Hemorrhage; Chloral Hydrate; Drug Combinations; Emergency | 2011 |
Fever after subarachnoid hemorrhage: risk factors and impact on outcome.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Brain; Cerebral Hemorrhage; Cognition Dis | 2007 |
Neonatal intracranial hemorrhage and maternal use of aspirin.
Topics: Acetaminophen; Aspirin; Cerebral Hemorrhage; Female; Gestational Age; Humans; Infant, Low Birth Weig | 1981 |
Can acetaminophen excess result in maternal and fetal toxicity?
Topics: Acetaminophen; Adult; Blood Coagulation Disorders; Cerebral Hemorrhage; Chemical and Drug Induced Li | 1990 |