acetaminophen has been researched along with Bone Fractures in 25 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "9%) patients in acetaminophen/oxycodone group experienced nausea that was statistically significant higher (P value = 0." | 9.19 | Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial. ( Abbasi, S; Farsi, D; Fathi, M; Ghalyaie, AH; Hafezimoghadam, P; Zare, MA, 2014) |
| "We compare the treatment of pain in children with arm fractures by ibuprofen 10 mg/kg versus acetaminophen with codeine 1 mg/kg/dose (codeine component)." | 9.14 | A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain. ( Brousseau, DC; Drendel, AL; Gorelick, MH; Kim, MK; Lyon, R; Weisman, SJ, 2009) |
| "For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1." | 5.33 | Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis. ( Mosekilde, L; Rejnmark, L; Vestergaard, P, 2006) |
| "9%) patients in acetaminophen/oxycodone group experienced nausea that was statistically significant higher (P value = 0." | 5.19 | Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial. ( Abbasi, S; Farsi, D; Fathi, M; Ghalyaie, AH; Hafezimoghadam, P; Zare, MA, 2014) |
| "We compare the treatment of pain in children with arm fractures by ibuprofen 10 mg/kg versus acetaminophen with codeine 1 mg/kg/dose (codeine component)." | 5.14 | A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain. ( Brousseau, DC; Drendel, AL; Gorelick, MH; Kim, MK; Lyon, R; Weisman, SJ, 2009) |
| " PPS was associated with reduced pain as well as a reduction in paracetamol and morphine use." | 4.12 | Immediate full weight bearing after pelvic percutaneous fixation by screw for simple acetabular and pelvic ring fractures in patients older than sixty five years. ( Benhenneda, R; Di Francia, R; Dubrana, F; Letissier, H, 2022) |
| " Ambulance officers' concern about the pain of injection is the major identified factor for the relative underuse of morphine observed in younger children." | 3.73 | Paediatric prehospital analgesia in Auckland. ( Watkins, N, 2006) |
| "IP-ZA along with standing multiple-doses-per-day acetaminophen, administered to patients in the immediate postfracture period, is not associated with significant acute adverse effects." | 1.91 | Safety of Inpatient Zoledronic Acid in the Immediate Postfracture Setting. ( Bolster, MB; Fan, W; Franco-Garcia, E; Leder, BZ; Ly, TV; Mannstadt, M, 2023) |
| "Ibuprofen appears to be a safe option for fracture-related pain." | 1.62 | An observational cohort study comparing ibuprofen and oxycodone in children with fractures. ( Ali, S; Carleton, B; Drendel, AL; Johnson, DW; LeMay, S; Manaloor, R; McGrath, PJ; Rosychuk, RJ, 2021) |
| "Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis, is an uncommon condition that is clinically characterized by painful, well-demarcated, indurated, erythematous plaques or nodules that typically favor the head, neck, and arms, and are accompanied by fever." | 1.46 | Sweet syndrome induced by oral acetaminophen-codeine following repair of a facial fracture. ( Bradley, LM; Halder, RM; Higgins, SP; Rodney, IJ; Thomas, MM, 2017) |
| "The usual treatment of venous ulcers may be associated with statins intake." | 1.42 | [2014 literature findings in internal general medicine]. ( Arnold, C; Barras, D; Bodenmann, P; Chiarini, B; Guinand, S; Pasche, O; Ronga, A; Vu, F; Zürcher, S, 2015) |
| "For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1." | 1.33 | Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis. ( Mosekilde, L; Rejnmark, L; Vestergaard, P, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (12.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (36.00) | 29.6817 |
| 2010's | 8 (32.00) | 24.3611 |
| 2020's | 5 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ali, S | 1 |
| Manaloor, R | 1 |
| Johnson, DW | 1 |
| Rosychuk, RJ | 1 |
| LeMay, S | 1 |
| Carleton, B | 1 |
| McGrath, PJ | 1 |
| Drendel, AL | 2 |
| Jenkin, DE | 1 |
| Naylor, JM | 1 |
| Descallar, J | 1 |
| Harris, IA | 1 |
| Benhenneda, R | 1 |
| Letissier, H | 1 |
| Dubrana, F | 1 |
| Di Francia, R | 1 |
| Fan, W | 1 |
| Leder, BZ | 1 |
| Mannstadt, M | 1 |
| Ly, TV | 1 |
| Franco-Garcia, E | 1 |
| Bolster, MB | 1 |
| Gao, T | 1 |
| Zhu, H | 1 |
| Zhang, C | 1 |
| Chai, Y | 1 |
| Guo, C | 1 |
| Zhu, X | 1 |
| Bao, B | 1 |
| Li, X | 1 |
| Lin, J | 1 |
| Zheng, X | 1 |
| Mayer, J | 1 |
| Willis, L | 1 |
| Bradley, LM | 1 |
| Higgins, SP | 1 |
| Thomas, MM | 1 |
| Rodney, IJ | 1 |
| Halder, RM | 1 |
| Helmerhorst, GTT | 1 |
| Zwiers, R | 1 |
| Ring, D | 1 |
| Kloen, P | 1 |
| Visconti, A | 1 |
| Zare, MA | 1 |
| Ghalyaie, AH | 1 |
| Fathi, M | 1 |
| Farsi, D | 1 |
| Abbasi, S | 1 |
| Hafezimoghadam, P | 1 |
| Vu, F | 1 |
| Guinand, S | 1 |
| Pasche, O | 1 |
| Zürcher, S | 1 |
| Ronga, A | 1 |
| Arnold, C | 1 |
| Barras, D | 1 |
| Chiarini, B | 1 |
| Bodenmann, P | 1 |
| Yeh, KT | 1 |
| Wu, WT | 1 |
| Subeq, YM | 1 |
| Niu, CC | 1 |
| Liao, KW | 1 |
| Chen, IH | 1 |
| Wang, JH | 1 |
| Lee, RP | 1 |
| MacPherson, R | 1 |
| Gorelick, MH | 1 |
| Weisman, SJ | 1 |
| Lyon, R | 1 |
| Brousseau, DC | 1 |
| Kim, MK | 1 |
| Bach, SM | 1 |
| Holten, KB | 1 |
| Shepherd, M | 1 |
| Aickin, R | 1 |
| Williams, LJ | 1 |
| Pasco, JA | 1 |
| Henry, MJ | 1 |
| Sanders, KM | 1 |
| Nicholson, GC | 1 |
| Kotowicz, MA | 1 |
| Berk, M | 1 |
| MUELLER, EH | 1 |
| Watkins, N | 1 |
| Vestergaard, P | 1 |
| Rejnmark, L | 1 |
| Mosekilde, L | 1 |
| Lee, YS | 1 |
| Lin, CC | 1 |
| Huang, CR | 1 |
| Chen, CN | 1 |
| Liao, WY | 1 |
| Ozkalkanli, MY | 1 |
| Katircioglu, K | 1 |
| Duzenli, VE | 1 |
| Unal, I | 1 |
| Savaci, S | 1 |
| Keil, HR | 1 |
| Fronia, W | 1 |
| Doutre, LP | 1 |
| Périssat, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Standardization of Post-operative Opiate Prescriptions for Same-day Ankle and Wrist Fracture Surgeries[NCT05322564] | 100 participants (Anticipated) | Interventional | 2022-05-31 | Not yet recruiting | |||
| A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy[NCT01267136] | Phase 4 | 84 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Ibuprofen vs. Codeine. Is One Better for Post-operative Pain Relief Following Reduction of Paediatric Forearm Fractures?[NCT01605240] | 50 participants (Anticipated) | Interventional | 2012-07-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Average number of post-operative days with pain score >4/10. Pain score assessments were administered once daily by parents using either the Numeric Rating Scale (NRS-11) (with anchors 0=no pain and 10=highest pain imaginable) for children ages 8-15 (von Baeyer et al., 2009) or the Faces Pain Scale-Revised (FPS-R) (with anchors 0=no pain and 10=highest pain imaginable) for children ages 4-10 (Hicks et al., 2001). (NCT01267136)
Timeframe: Efficacy was assessed daily during the 10-day postoperative recovery period.
| Intervention | days (Median) |
|---|---|
| Capital® With Codeine Suspension | 1.5 |
| Tramadol Suspension | 1 |
Parent-reported side effects entered in 10-day diary. (NCT01267136)
Timeframe: Side effects will be observed and recorded daily by caregivers for a total of 10 days in the take-home diary.
| Intervention | participants (Number) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Nausea | Vomiting | Fever | Itching | Rash | Sweating | Dizziness | Headache | Constipation | Oversedation | Tonsil bleed | |
| Capital® With Codeine Suspension | 20 | 21 | 11 | 5 | 1 | 9 | 15 | 12 | 21 | 14 | 3 |
| Tramadol Suspension | 20 | 18 | 10 | 12 | 1 | 7 | 17 | 17 | 21 | 8 | 0 |
7 trials available for acetaminophen and Bone Fractures
| Article | Year |
|---|---|
Effectiveness of Oxycodone Hydrochloride (Strong Opioid) vs Combination Acetaminophen and Codeine (Mild Opioid) for Subacute Pain After Fractures Managed Surgically: A Randomized Clinical Trial.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Australia; Codeine; Double-Blind Method; Drug Combinations | 2021 |
Pain Relief After Operative Treatment of an Extremity Fracture: A Noninferiority Randomized Controlled Trial.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opi | 2017 |
Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial.
Topics: Acetaminophen; Acute Disease; Administration, Intravenous; Administration, Oral; Adult; Analgesics, | 2014 |
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain.
Topics: Acetaminophen; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschool; Codeine; Double-Blind | 2009 |
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain.
Topics: Acetaminophen; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschool; Codeine; Double-Blind | 2009 |
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain.
Topics: Acetaminophen; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschool; Codeine; Double-Blind | 2009 |
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain.
Topics: Acetaminophen; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschool; Codeine; Double-Blind | 2009 |
Paracetamol versus ibuprofen: a randomized controlled trial of outpatient analgesia efficacy for paediatric acute limb fractures.
Topics: Acetaminophen; Acute Disease; Adolescent; Ambulatory Care; Analgesics, Non-Narcotic; Analysis of Var | 2009 |
...And what's best for fracture pain in children?
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Codeine; Drug Combin | 2009 |
Operative treatment of midclavicular fractures in 62 elderly patients: knowles pin versus plate.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Bone Nails; Bo | 2007 |
18 other studies available for acetaminophen and Bone Fractures
| Article | Year |
|---|---|
An observational cohort study comparing ibuprofen and oxycodone in children with fractures.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Child, Preschool; Co | 2021 |
Immediate full weight bearing after pelvic percutaneous fixation by screw for simple acetabular and pelvic ring fractures in patients older than sixty five years.
Topics: Acetaminophen; Bone Screws; Fractures, Bone; Humans; Morphine; Pain; Retrospective Studies; Weight-B | 2022 |
Safety of Inpatient Zoledronic Acid in the Immediate Postfracture Setting.
Topics: Acetaminophen; Bone Density Conservation Agents; Calcium; Creatinine; Diphosphonates; Fractures, Bon | 2023 |
Efficacy of acetaminophen with and without oxycodone for analgesia in non-operative treatment of extremity fractures in adults: protocol for a double-blind randomized clinical trial.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Double-Blind Method; Drug Combinations; E | 2019 |
Toxic leukoencephalopathy-When a Boxer's fracture requires an MRI and LP.
Topics: Acetaminophen; Adult; Cocaine-Related Disorders; Confusion; Contrast Media; Drug Combinations; Fract | 2021 |
Sweet syndrome induced by oral acetaminophen-codeine following repair of a facial fracture.
Topics: Acetaminophen; Adult; Codeine; Diabetes Mellitus, Type 2; Diagnosis, Differential; Drug Combinations | 2017 |
Opioids for Acute Pain: Proceed with Caution.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Opioid; Chronic Pain; Drug Combinations; Female; Fract | 2018 |
[2014 literature findings in internal general medicine].
Topics: Acetaminophen; Adolescent; Aged; Analgesics, Non-Narcotic; Bronchitis; Bullying; Colorectal Neoplasm | 2015 |
Non-Steroid Anti-Inflammatory Drugs Are Better than Acetaminophen on Fever Control at Acute Stage of Fracture.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Female; Fev | 2015 |
Listen to the patient.
Topics: Acetaminophen; Bicarbonates; Deglutition Disorders; Drug Combinations; Female; Fractures, Bone; Huma | 2008 |
Guideline update: what's the best approach to acute low back pain?
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cry | 2009 |
Paracetamol (acetaminophen) use, fracture and bone mineral density.
Topics: Acetaminophen; Aged; Bone Density; Case-Control Studies; Female; Fractures, Bone; Humans; Middle Age | 2011 |
[CLINICAL TRIALS WITH LONARID IN ORTHOPEDICS].
Topics: Acetaminophen; Biomedical Research; Fractures, Bone; Humans; Joint Diseases; Orthopedic Procedures; | 1964 |
Paediatric prehospital analgesia in Auckland.
Topics: Acetaminophen; Adolescent; Age Factors; Analgesia; Analgesics; Burns; Child; Child, Preschool; Drug | 2006 |
Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; | 2006 |
Brachial plexus block for the child with Kartagener's syndrome.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics, Intravenous; Brachial Plexus; Child; Dextrocar | 2008 |
[Clinical studies with the new two-component analgesic Panagesic].
Topics: Acetaminophen; Adult; Aged; Analgesics; Burns; Drug Combinations; Drug Evaluation; Female; Fractures | 1979 |
[Propofan as an antalgic in general surgery. Apropos of 50 cases].
Topics: Acetaminophen; Analgesics; Aspirin; Bone Diseases; Caffeine; Chlorpheniramine; Dextropropoxyphene; D | 1972 |