acetaminophen and Body Weight studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Research Excerpts

Excerpt	Relevance	Reference
" This study evaluated the effect of a weight-based dosing chart (WBDC) introduced to decrease NAC prescription errors."	5.39	Introduction of an N-acetylcysteine weight-based dosing chart reduces prescription errors in the treatment of paracetamol poisoning. ( Greene, S; McD Taylor, D; McIntyre, S, 2013)
"This study of 45 patients aimed to retrospectively examine whether the relationships among the postoperative to preoperative body weight ratio (BWR), meal intake as a good indicator of quality of l ife (QOL), and absorptive kinetics from the small intestine could be expressed by the acetaminophen (AAP) concentration."	3.91	Functional Evaluation for Various Methods of Gastrectomy and Reconstruction for Gastric Cancer. ( Izumi, H; Kawai, M; Kayano, H; Lee, SW; Machida, T; Mukai, M; Nabeshima, K; Nakamura, K; Nomura, E; Uchiyama, K; Uda, S; Yamamoto, S, 2019)
"The aim of the present study was to evaluate the sub-acute oral toxicity of acetaminophen in Sprague Dawley (SD) rats at 250 to 1000 mg/kg body weight (b."	3.80	Sub-acute toxicity studies of acetaminophen in Sprague Dawley rats. ( Deecaraman, M; Sakthivelan, SM; Venkatesan, PS; Vijayalakshmi, M, 2014)
"This study tested if acetaminophen, N-methyl-D-glucamine dithiocarbamate (NMGDTC), deferoxamine, and combinations of these agents reduce excess iron content, prevent iron-induced pathology, reduce cardiac arrhythmias, and reduce mortality in iron-overloaded gerbils."	3.75	Acetaminophen combinations protect against iron-induced cardiac damage in gerbils. ( Blough, ER; Dornon, L; Laurino, JP; Morrison, RG; Rice, KM; Studeny, M; Walker, EM; Walker, SM; Wehner, PS; Wu, M, 2009)
"The results of this survey concerning antipyretic treatment of children by their Jewish and Bedouin Moslem caregivers suggest that lighter body weight and the use of acetaminophen rectal suppositories were associated with the administration of higher-than-recommended doses of acetaminophen."	3.73	Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study. ( Bilenko, N; Gorodischer, R; Okbe, R; Press, J; Tessler, H, 2006)
" The objective of the present investigation was to study some of the possible mechanisms involved in the protective effect of sucrose ingestion against liver necrosis induced by acetaminophen."	3.68	Cytochrome P450 and glutathione in the liver of rats under exclusive sucrose ingestion. ( Martinelli, AL; Meneghelli, UG; Zucoloto, S, 1993)
" Rats were initially given a single ip injection of diethylnitrosamine (200 mg/kg body weight) and fed basal diet containing 0."	3.67	Inhibitory effects of ethoxyquin, 4,4'-diaminodiphenylmethane and acetaminophen on rat hepatocarcinogenesis. ( Inoue, K; Ito, N; Masui, T; Ogiso, T; Tsuda, H, 1986)
" Adult intact male and female Sprague-Dawley rats were administered labeled acetaminophen (1 g/kg body weight + 5 microCi [3H]acetaminophen) after an overnight fast."	3.66	Hepatotoxicity and metabolism of acetaminophen in male and female rats. ( Cho, C; Linscheer, WG; Raheja, KL, 1983)
"Nefopam is a centrally acting analgesic which has a theoretical risk of stopping lactation due to its anticholinergic and dopaminergic effects."	2.84	The effect of nefopam on lactation after caesarean section: a single-blind randomised trial. ( Baka, NE; Bouaziz, H; Guerci, P; Hubert, C; Iohom, G; Rouabah, M; Vial, F, 2017)
"acetaminophen was administered over 15, 60, or 120 min."	2.84	Population pharmacokinetics of intravenous acetaminophen in Japanese patients undergoing elective surgery. ( Hasegawa, M; Imaizumi, T; Iseki, Y; Mogami, M; Murakawa, M; Obara, S, 2017)
"581 per hour for absorption rate constant (Ka )."	2.82	Pooled Post Hoc Analysis of Population Pharmacokinetics of Oxycodone and Acetaminophen Following Multiple Oral Doses of Biphasic Immediate-Release/Extended-Release Oxycodone/Acetaminophen Tablets. ( Devarakonda, K; Franke, R; Morton, T, 2016)
" Despite this approval, pediatric pharmacokinetic data using this product have not been previously published."	2.80	Pharmacokinetics of hydrocodone/acetaminophen combination product in children ages 6-17 with moderate to moderately severe postoperative pain. ( Awni, W; Dutta, S; Kearns, G; Liu, W; Neville, KA, 2015)
" This study investigates paracetamol clearance in neonates and infants after single and multiple dosing using a population modelling approach."	2.80	Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants. ( Allegaert, K; Danhof, M; de Hoon, J; Knibbe, CA; Krekels, EH; Tibboel, D; van Ham, S, 2015)
" tables of normal and abnormal ranges of temperature, recommended temperature measurement techniques, dosage regimen of antipyretic drugs, guidelines to parents), justifying the implementation of a pharmaceutical follow-up."	2.71	When fever, paracetamol? Theory and practice in a paediatric outpatient clinic. ( Cotting, JQ; Di Paolo, ER; Djahnine, SR; Gehri, M; Guignard, E; Krahenbuhl, JD; Pannatier, A; Yersin, C, 2005)
"Acetaminophen was chosen as our overdose drug because it has relatively few side effects, serum levels are easily attainable and measurable, and it is generally a common drug overdose."	2.71	Efficacy of superactivated charcoal administered late (3 hours) after acetaminophen overdose. ( Enoki, NR; Marn, RY; Sato, RL; Sumida, SM; Wong, JJ; Yamamoto, LG, 2003)
"We have examined acetaminophen (paracetamol) dosing for outpatient management of posttonsillectomy pain in children."	2.69	Examination of acetaminophen for outpatient management of postoperative pain in children. ( Harder, A; Hertel, S; Rasmussen, M; Rømsing, J, 1998)
"Ibuprofen was evaluated as an antipyretic agent in 178 children (aged 3 months to 12 years) to compare dosage (5 vs 10 mg/kg), establish absolute efficacy (with a placebo control group), determine relative efficacy (ibuprofen vs acetaminophen), evaluate maximum efficacy, and identify potential confounding variables."	2.67	Single-dose, placebo-controlled comparative study of ibuprofen and acetaminophen antipyresis in children. ( Bertrand, KM; Brown, RD; Eichler, VF; Johnson, VA; Kearns, GL; Lowe, BA; Wilson, JT, 1991)
" The mean half-life was significantly lower and oral clearance was significantly higher in the first trimester group compared to the control group."	2.67	Paracetamol pharmacokinetics during the first trimester of human pregnancy. ( Beaulac-Baillargeon, L; Rocheleau, S, 1994)
"Acetaminophen is a commonly used pediatric medication that has recently been approved for intravenous use in the United States."	2.52	Intravenous acetaminophen use in pediatrics. ( Shastri, N, 2015)
" Administration groups were pretreated with high and low-dose dry dandelion extract (1,000 or 500 g fresh herb dried and then decocted into 120 mL solution, DDE-H and DDE-L); low-, medium- and high-dose dandelion juice (250, 500, 1,000 g/120 mL, DJ-L, DJ-M, and DJ-H); fresh dandelions evaporation juice water (120 mL, DEJW); dry dandelion extract dissolved by pure water (1 kg/120 mL, DDED-PW); dry dandelion extract dissolved by DEJW (120 g/120 mL, DDED-DEJW) by oral gavage for 7 days at the dosage of 0."	1.72	Protective Effect of Fresh/Dry Dandelion Extracts on APAP-Overdose-Induced Acute Liver Injury. ( Ai, J; Deng, X; Lei, L; Li, YQ; Liang, S; Pu, SB; Ren, YS; Zhang, TP; Zheng, Y, 2022)
" A two-compartment pharmacokinetic model with first-order elimination described disposition for both drugs."	1.72	Population Pharmacokinetic Modelling of Acetaminophen and Ibuprofen: the Influence of Body Composition, Formulation and Feeding in Healthy Adult Volunteers. ( Anderson, BJ; Atkinson, HC; Morse, JD; Stanescu, I, 2022)
"To describe paracetamol dosing and liver function test (LFT) monitoring in older hospital inpatients who are frail or have low body weight."	1.72	Paracetamol dosing in hospital and on discharge for older people who are frail or have low body weight. ( Elliott, RA; Lalic, S; Ngo, J; Reid, O; Su, E, 2022)
" tuberculata at the doses of (1 ml/kg, 2 ml/kg and 3 ml/kg body weight) were significantly lower when compared to toxic control mice group (P<0."	1.72	Hepatoprotective effects of walnut oil and Caralluma tuberculata against paracetamol in experimentally induced liver toxicity in mice. ( Alharbi, M; Ali, W; Alshammari, A; Aziz, T; Iqbal, Z; Jamil, S; Khan, AA; Khan, FF; Shahzad, M; Ur Rahman, S; Zahid, M, 2022)
"Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease which affects millions of people worldwide."	1.51	Acetaminophen aggravates fat accumulation in NAFLD by inhibiting autophagy via the AMPK/mTOR pathway. ( Han, B; Hu, C; Shi, C; Xue, W; Yang, F; Yin, Y, 2019)
" The objective of this study is to determine if missing body weights in preterm and term neonates affect estimates of model parameters and which methods can be used to improve performance of a population pharmacokinetic model of paracetamol."	1.51	Population Pharmacokinetic Modeling in the Presence of Missing Time-Dependent Covariates: Impact of Body Weight on Pharmacokinetics of Paracetamol in Neonates. ( Allegaert, K; Cook, SF; Krzyzanski, W; Sherwin, CMT; van den Anker, JN; Vermeulen, A; Wilbaux, M, 2019)
"The aims of this study were to develop a population pharmacokinetic model for intravenous paracetamol in preterm and term neonates and to assess the generalizability of the model by testing its predictive performance in an external dataset."	1.43	Population Pharmacokinetics of Intravenous Paracetamol (Acetaminophen) in Preterm and Term Neonates: Model Development and External Evaluation. ( Allegaert, K; Cook, SF; Deutsch, N; King, AD; Roberts, JK; Samiee-Zafarghandy, S; Sherwin, CM; Stockmann, C; van den Anker, JN; Wilkins, DG; Williams, EF, 2016)
" Two hundred forty-one patients (80%) were appropriately dosed, whereas 59 (20%) patients were not appropriately dosed based on the FDA-approved dosing."	1.40	Postmarketing review of intravenous acetaminophen dosing based on Food and Drug Administration prescribing guidelines. ( dela Cruz Ubaldo, C; Hall, NS; Le, B, 2014)
"Acetaminophen (APAP) is an antipyretic analgesic drug that when taken in overdose causes depletion of glutathione (GSH) and hepatotoxicity."	1.39	Therapeutic effect of liposomal-N-acetylcysteine against acetaminophen-induced hepatotoxicity. ( Alipour, M; Buonocore, C; Omri, A; Pucaj, K; Suntres, ZE; Szabo, M, 2013)
" Forty-six parents (32%) had an acetaminophen dosing error."	1.39	Parental language and dosing errors after discharge from the pediatric emergency department. ( Porter, SC; Samuels-Kalow, ME; Stack, AM, 2013)
" This study evaluated the effect of a weight-based dosing chart (WBDC) introduced to decrease NAC prescription errors."	1.39	Introduction of an N-acetylcysteine weight-based dosing chart reduces prescription errors in the treatment of paracetamol poisoning. ( Greene, S; McD Taylor, D; McIntyre, S, 2013)
" A recent study highlighted the risk of overdose of paracetamol using British National Formulary for Children (BNFC) age-based dosing guidelines."	1.38	Proposed MHRA changes to UK children's paracetamol dosing recommendations: modelling study. ( Beasley, R; Eyers, S; Fingleton, J; Perrin, K, 2012)
" Despite these differences, even commonly administered drugs have not undergone pharmacokinetic evaluation in pregnant women or at delivery."	1.38	Paracetamol and ketorolac pharmacokinetics and metabolism at delivery and during postpartum. ( Allegaert, K; Hendrickx, S; Kelchtermans, J; Kulo, A; Smits, A; van Calsteren, K; van de Velde, M, 2012)
" Age-based dosing guidelines can lead to inappropriate dosing."	1.38	British National Formulary for Children: the risk of inappropriate paracetamol prescribing. ( Beasley, R; Eastwood, A; Eyers, S; Fingleton, J; Perrin, K, 2012)
"The hyperplasia was usually accompanied by hyperkeratosis resulting in thickening of the stratum corneum."	1.37	Acetaminophen-induced forestomach lesion in normal rats following intravenous exposure. ( Gass, JH; McKee, JS, 2011)
"A population pharmacokinetic analysis of 943 paracetamol observations from 158 neonates (27-45 weeks' postmenstrual age (PMA)) was undertaken using non-linear mixed effects models."	1.37	The pharmacokinetics of intravenous paracetamol in neonates: size matters most. ( Allegaert, K; Anderson, BJ; Palmer, GM, 2011)
"The antiviral drug combination consisting of arbidol and acetaminophen was investigated for its 4-week repeated oral administration in Sprague-Dawley rats."	1.36	A 4-week oral toxicity study of an antiviral drug combination consisting of arbidol and acetaminophen in rats. ( Bai, WX; Liu, J; Pan, WN; Pan, YY; Shu, B; Wang, M; Yao, J, 2010)
"Acetaminophen (APAP) was included in the study since indications of immunomodulating properties of this compound have appeared in the literature."	1.35	Overlapping gene expression profiles of model compounds provide opportunities for immunotoxicity screening. ( Baken, KA; Breit, TM; de Vries, A; Jonker, MJ; Pennings, JL; Schaap, MM; van Loveren, H; van Steeg, H, 2008)
" The dosing range for acetaminophen was 10-15 mg/kg every four to six hours as needed, and the regimen for ibuprofen was 5-10 mg/kg every six to eight hours as needed."	1.35	Effect of a weight-based prescribing method within an electronic health record on prescribing errors. ( Barr, WB; Ginzburg, R; Harris, M; Munshi, S, 2009)
" prodrug of acetaminophen (propacetamol) in neonates after repeat dosing are reported, with scant data for i."	1.35	I.V. acetaminophen pharmacokinetics in neonates after multiple doses. ( Anderson, BJ; Atkins, M; Chalkiadis, GA; Culnane, TJ; Hunt, RW; McNally, CM; Palmer, GM; Perkins, EJ; Smith, KR, 2008)
"Ibuprofen dosage was 51% (P<0."	1.34	Paediatric analgesia in the emergency department, are we getting it right? ( Blair, L; Clark, M; Donald, C; Duncan, R; Thakore, S, 2007)
"Acetaminophen was given in the diet either alone at 2400 or 4800 p."	1.34	Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene. ( Duan, JD; Iatropoulos, MJ; Jeffrey, AM; Perrone, CE; Williams, GM, 2007)
"In this clinically relevant septic shock model, the febrile response thus resulted in better respiratory function, lower blood lactate concentration, and prolonged survival time."	1.33	Fever control in septic shock: beneficial or harmful? ( Cai, Y; Nguyen, ND; Rogiers, P; Su, F; Vincent, JL; Wang, Z, 2005)
" A population pharmacokinetic analysis of paracetamol (acetaminophen) time-concentration profiles in 48 neonates was undertaken using non-linear mixed-effects models."	1.32	Intravenous paracetamol (propacetamol) pharmacokinetics in term and preterm neonates. ( Allegaert, K; Anderson, BJ; de Hoon, J; Debeer, A; Devlieger, H; Naulaers, G; Tibboel, D; Verbesselt, R, 2004)
"Repeated dosing of acetaminophen (paracetamol) to rats is reported to decrease their sensitivity to its hepatotoxic effects, which are associated with oxidative stress and glutathione depletion."	1.31	Repeated acetaminophen dosing in rats: adaptation of hepatic antioxidant system. ( Birmingham, JM; Bugelski, PJ; Elcock, F; Greenhill, RW; O'Brien, PJ; Slaughter, MR; Swain, A, 2000)
"The aim of the study was to evaluate the toxic effect of acetaminophen on rat fetuses."	1.31	Embryofetotoxicity of acetaminophen (paracetamol) in experimental in vivo model. ( Blicharski, T; Burdan, F; Kiś, G; Siezieniewska, Z, 2001)
" They were found fairly potent in rat tail flick and mouse phenylquinone writhing assays but the dose-response curves were rather shallow as compared to that of morphine."	1.30	Apparent antinociceptive and anti-inflammatory effects of GYKI 52466. ( Kedves, R; Máté, I; Székely, JI; Tarnawa, I; Török, K, 1997)
" exposures of microwave radiation [Specific Absorption Rate = 0."	1.30	Acetaminophen effects on behavioral thermoregulation in albino rats. ( Blake, SE; Kaiser, GA; Luper, SL; Maranto, DL; McPherson, KP; Storey, TM; Vitulli, WF, 1999)
"Despite widespread use in children pharmacokinetic data about paracetamol are relatively scarce, not the least in the youngest age groups."	1.30	Plasma paracetamol concentrations and pharmacokinetics following rectal administration in neonates and young infants. ( Hansen, TG; Morton, NS; O'Brien, K; Rasmussen, SN, 1999)
"The analgesic drug combination Thomapyrin consisting of acetylsalicylic acid (CAS 50-78-2, ASA), paracetamol (CAS 103-90-2, NAPAP) and caffeine (CAS 58-08-2) in the ratio 5:4:1 was investigated for its chronic toxicity in rats."	1.29	Studies on the chronic oral toxicity of an analgesic drug combination consisting of acetylsalicylic acid, paracetamol and caffeine in rats including an electron microscopical evaluation of kidneys. ( Bauer, E; Bauer, M; Greischel, A; Hirsch, U; Lehmann, H; Schmid, J; Schneider, P, 1996)
" There are no dosing guidelines for paracetamol use in children under 1 month of age."	1.29	Paracetamol prescribing habits in a children's hospital. ( Anderson, B; Anderson, M; Hastie, B, 1996)
"5 mg/ml caused a greater increase in leukocytosis in dosed transplant recipients in comparison to that experienced by undosed recipients: trichlorfon at 2."	1.28	The effects of iodinated glycerol, trichlorfon, and acetaminophen on tumor progression in a Fischer rat leukemia transplant model. ( Dieter, MP; Jameson, CW; Maronpot, RR; Ward, SM, 1992)
"Acetaminophen (APAP) was evaluated for reproductive toxicity in Swiss CD-1 mice using a continuous breeding protocol."	1.28	Reproductive toxicity evaluation of acetaminophen in Swiss CD-1 mice using a continuous breeding protocol. ( Lamb, JC; Lawton, AD; Reel, JR, 1992)
"The effect of long-term administration of acetaminophen to rats on the dietary protein utilization was investigated using protein-sufficient and protein-deficient diets."	1.28	Effects of long-term administration of acetaminophen on the nutritional utilization of dietary protein. ( Ruiz-Roso, B; Varela, G; Varela-Moreiras, G, 1991)
"Acetaminophen was included in the studies as an example of an analgesic agent which lacks anti-inflammatory efficacy."	1.28	Effects of ibuprofen on doxorubicin toxicity. ( Inchiosa, MA; Smith, CM, 1990)
" We suggest that the enhancement of acetaminophen toxicity by ethanol is the result of an effect of ethanol on hepatocyte membranes which renders the cells more susceptible to toxic injury."	1.27	Increased acetaminophen-induced hepatotoxicity after chronic ethanol consumption in mice. ( Massey, TE; McElligott, TF; Power, EM; Racz, WJ; Walker, RM, 1983)
" Based on available clinical and pharmacokinetic data, acetaminophen should be dosed with single doses in the range of 10-15 mg/kg at 4-hour intervals."	1.27	Pediatric dosing of acetaminophen. ( Temple, AR, 1983)
" After riboflavin deficiency was established by determining erythrocyte glutathione reductase activity coefficient, rats in all groups were administered a toxic dose of acetaminophen (1 g/kg body weight) orally."	1.27	Effect of riboflavin status on acetaminophen toxicity in the rat. ( Cho, C; Linscheer, WG; Raheja, KL; Turkki, PR, 1983)
" A toxic dose of the drug ( LD20 ) produced elevated serum glutamate-pyruvate transaminase and lactate dehydrogenase activities 20-24 hr after drug administration only in 19- and 33-day-old animals."	1.27	Hepatotoxicity of acetaminophen in neonatal and young rats. I. Age-related changes in susceptibility. ( Fischer, LJ; Green, MD; Shires, TK, 1984)
"To evaluate the degree of toxicity to the liver of chronic administration of acetaminophen, the slides from two independent previously reported experiments using different strains of mouse were reviewed and compared."	1.27	Hepatotoxicity of chronic high dose administration of acetaminophen to mice. A critical review and implications for hazard assessment. ( Maruyama, H; Williams, GM, 1988)
"The effect of dosing paracetamol, 4."	1.27	Long-term administration of toxic doses of paracetamol (acetaminophen) to rats. ( Poulsen, HE; Thomsen, P, 1988)
" The operative status of the hepatic GSH conjugative system has an important influence on the rate of elimination of toxic APAP doses."	1.27	Time development of distribution and toxicity following single toxic APAP doses in male BOM:NMRI mice. ( Ingebrigtsen, K; Jansen, JH; Nafstad, I; Skoglund, LA, 1987)
" The results showed that the combination was no more toxic than paracetamol alone and, on the basis of the LD50:ED50 ratio, was less toxic by the oral than by the rectal route."	1.27	Acute toxicity and analgesic action of a combination of buclizine, codeine and paracetamol ('Migraleve') in tablet and suppository form in rats. ( Behrendt, WA; Cserepes, J, 1985)
" Oral contraceptive steroid subjects had a lower elimination half-life of acetaminophen (2."	1.26	Increased metabolic clearance of acetaminophen with oral contraceptive use. ( Abernethy, DR; Ameer, B; Divoll, M; Greenblatt, DJ; Ochs, HR, 1982)
"Male Wistar rats were dosed daily by gavage for 200 days with either (1) aspirin, 200 mg/kg; (2) acetaminophen, 200 mg/kg; (3) aspirin and acetaminophen, 200 mg/kg of each; (4) aspirin and acetaminophen, 100 mg/kg of each or (5) vehicle alone."	1.26	Failure to observe pathology in the rat following chronic dosing with acetaminophen and acetylsalicylic acid. ( Nera, EA; Thomas, BH; Zeitz, W, 1977)

Research

Studies (155)

Authors

Clinical Trials (9)

Trial Overview

Trial Outcomes

Intra- and Post-operative Serum Concentrations

Timeframe	Studies, this research(%)	All Research%
pre-1990	49 (31.61)	18.7374
1990's	27 (17.42)	18.2507
2000's	33 (21.29)	29.6817
2010's	40 (25.81)	24.3611
2020's	6 (3.87)	2.80

Authors	Studies
Zheng, Y	1
Lei, L	1
Liang, S	1
Ai, J	1
Deng, X	1
Li, YQ	1
Zhang, TP	1
Pu, SB	1
Ren, YS	1
van der Heijden, LT	1
Mian, P	2
Hias, J	1
de Winter, BCM	1
Tournoy, J	1
Van der Linden, L	1
Tibboel, D	6
Walgraeve, K	1
Flamaing, J	1
Koch, BCP	2
Allegaert, K	11
Spriet, I	1
Morse, JD	1
Stanescu, I	1
Atkinson, HC	1
Anderson, BJ	6
Reid, O	1
Ngo, J	1
Lalic, S	1
Su, E	1
Elliott, RA	1
Ur Rahman, S	1
Zahid, M	1
Khan, AA	1
Aziz, T	1
Iqbal, Z	1
Ali, W	1
Khan, FF	1
Jamil, S	1
Shahzad, M	1
Alharbi, M	1
Alshammari, A	1
Makhdoom, S	2
Maqbool, A	2
Muhammad, H	2
Makhdoom, M	2
Ashraf, H	2
Khan, WA	2
Irfan, M	2
Nomura, E	2
Kayano, H	2
Machida, T	2
Uda, S	1
Nabeshima, K	2
Nakamura, K	2
Lee, SW	2
Kawai, M	2
Izumi, H	1
Yamamoto, S	2
Mukai, M	2
Uchiyama, K	2
Baka, NE	1
Vial, F	1
Iohom, G	1
Guerci, P	1
Hubert, C	1
Rouabah, M	1
Bouaziz, H	1
Imaizumi, T	1
Obara, S	1
Mogami, M	1
Iseki, Y	1
Hasegawa, M	1
Murakawa, M	1
Valkenburg, AJ	1
Breatnach, CV	1
Knibbe, CAJ	1
Krekels, EHJ	1
Shi, C	1
Xue, W	1
Han, B	1
Yang, F	1
Yin, Y	1
Hu, C	1
Krzyzanski, W	1
Cook, SF	2
Wilbaux, M	1
Sherwin, CMT	1
Vermeulen, A	1
van den Anker, JN	2
Alipour, M	1
Buonocore, C	1
Omri, A	1
Szabo, M	1
Pucaj, K	1
Suntres, ZE	1
Schwarz, ES	1
Mullins, ME	1
McIntyre, S	2
Greene, S	2
McD Taylor, D	2
Samuels-Kalow, ME	1
Stack, AM	1
Porter, SC	1
Charpiat, B	1
Bedouch, P	1
Rose, FX	1
Juste, M	1
Roubille, R	1
Conort, O	1
Allenet, B	1
Veyckemans, F	2
Kulo, A	3
Van Calsteren, K	3
van de Velde, M	2
Mulabegovic, N	1
Verbesselt, R	4
de Hoon, JN	2
Verhaeghe, J	1
Beleyn, B	1
Vermeersch, S	1
Smits, A	2
Venkatesan, PS	1
Deecaraman, M	1
Vijayalakshmi, M	1
Sakthivelan, SM	1
Liu, W	1
Dutta, S	1
Kearns, G	1
Awni, W	1
Neville, KA	1
Honmore, V	1
Kandhare, A	1
Zanwar, AA	1
Rojatkar, S	1
Bodhankar, S	1
Natu, A	1
dela Cruz Ubaldo, C	1
Hall, NS	1
Le, B	1
Srinivasan, V	1
Corwin, D	1
Verceles, AC	1
Shastri, N	1
Krekels, EH	1
van Ham, S	1
de Hoon, J	3
Danhof, M	1
Knibbe, CA	1
Roberts, JK	1
Samiee-Zafarghandy, S	1
Stockmann, C	1
King, AD	1
Deutsch, N	1
Williams, EF	1
Wilkins, DG	1
Sherwin, CM	1
Morton, T	1
Franke, R	1
Devarakonda, K	1
Severin, AE	1
Petitpain, N	1
Scala-Bertola, J	1
Latarche, C	1
Yelehe-Okouma, M	1
Di Patrizio, P	1
Gillet, P	1
Suzuki, Y	1
Goto, K	1
Nakayama, Y	1
Saratani, M	1
Takata, T	1
Okamoto, T	1
Okazaki, S	1
Shanmugam, S	1
Sivaraj, D	1
Dos Santos Lima, B	1
Dos Passos Menezes, P	1
de Carvalho, YMBG	1
de Souza Araújo, AA	1
Narain, N	1
Serafini, MR	1
Quintans Júnior, LJ	1
Scotti, L	1
Scotti, MT	1
Parimelazhagan, T	1
Elke, B	1
Zimmerli, L	1
Battegay, E	1
Palmer, GM	2
Atkins, M	1
Smith, KR	1
Culnane, TJ	1
McNally, CM	1
Perkins, EJ	1
Chalkiadis, GA	1
Hunt, RW	1
Konstandi, M	1
Segos, D	1
Galanopoulou, P	1
Theocharis, S	1
Zarros, A	1
Lang, MA	1
Marselos, M	1
Liapi, C	1
Lee, JK	1
Abe, K	1
Bridges, AS	1
Patel, NJ	1
Raub, TJ	1
Pollack, GM	1
Brouwer, KL	1
Bauer, DJ	1
Christenson, TJ	1
Clark, KR	1
Powell, SK	1
Swain, RA	1
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Wang, M	1
Shu, B	1
Bai, WX	1
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Cameron, L	1
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Gomes, A	1
Das, M	1
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Chakravorty, AK	1
Das, B	1
Ganguly, DK	1
Vedasiromoni, JR	1
Sato, RL	1
Wong, JJ	1
Sumida, SM	1
Marn, RY	1
Enoki, NR	1
Yamamoto, LG	1
van der Marel, CD	1
Pluim, MA	1
de Jong, TH	1
Gonzalez, A	1
ANGERVALL, L	1
LEHMANN, L	1
BENGTSSON, U	1
Naulaers, G	1
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Devlieger, H	2
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Critchley, JA	1
Critchley, LA	1
Anderson, PJ	1
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Nguyen, ND	1
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Vincent, JL	1
Miller, RA	1
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Cotting, JQ	1
Yersin, C	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Disposition of Intravenous Paracetamol in Young Women, Including During Pregnancy, in Postpartum or When on Oral Contraceptives[NCT02590900]		69 participants (Actual)	Observational	2010-06-30	Completed
Use of Intravenous Acetaminophen in Adolescents and Pediatrics Undergoing Spinal Fusion Surgery: Randomized Controlled Trial[NCT04959591]	Phase 3	99 participants (Actual)	Interventional	2021-06-01	Completed
Metabolism and Toxicity of Acetaminophen in Preterm Infants[NCT01328808]	Phase 2/Phase 3	31 participants (Actual)	Interventional	2011-10-31	Active, not recruiting
Comparison of the Efficacy of IV Acetaminophen Versus IV Indomethacin in Treatment of Hemodynamically Significant PDA in VLBW Infants[NCT03537144]	Phase 3	37 participants (Actual)	Interventional	2016-06-30	Terminated (stopped due to Difficulty enrolling patients)
Paracetamol Versus Ibuprofen for Patent Ductus Arteriosus Closure in Preterm Infants. A Prospective, Randomized, Controlled, Double Blind, Multicenter Clinical Trial.[NCT02056223]	Phase 2/Phase 3	120 participants (Anticipated)	Interventional	2017-01-09	Suspended (stopped due to We enrolled only 53 patients)
The Pharmacokinetics of Intravenous Acetaminophen and Its Metabolites in Obese Children and Adolescents[NCT03192566]	Phase 3	6 participants (Anticipated)	Interventional	2016-08-31	Recruiting
Acetaminophen Pharmacokinetics in Bariatric Patients[NCT02982928]		11 participants (Actual)	Observational	2017-03-06	Completed
Postoperative Ibuprofen Use and Risk of Bleeding in Pediatric Tonsillectomy[NCT03385057]	Phase 1	0 participants (Actual)	Interventional	2018-09-30	Withdrawn (stopped due to Study design flaws; research design needed to be reconfigured)
The Copenhagen Analgesic Study[NCT04369222]		600 participants (Anticipated)	Observational	2020-03-01	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

To determine whether adequate serum concentration of acetaminophen is achieved. (NCT02982928)
Timeframe: 15-20 minutes; 30-40 minutes; 50-70 minutes; 80-100 minutes; 2 Hours, 4 Hours; 8 Hours; and 12-Hours Post-IV acetaminophen administration

Article	Year
The effect of nefopam on lactation after caesarean section: a single-blind randomised trial. International journal of obstetric anesthesia, 2017, Volume: 31 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anesthesia, Obstetrical; Anesthesia, Spinal; Body We	2017
Population pharmacokinetics of intravenous acetaminophen in Japanese patients undergoing elective surgery. Journal of anesthesia, 2017, Volume: 31, Issue:3 Topics: Acetaminophen; Administration, Intravenous; Adult; Aged; Anesthesia, General; Body Weight; Elective	2017
Estradiol and weight are covariates of paracetamol clearance in young women. Gynecologic and obstetric investigation, 2014, Volume: 77, Issue:4 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Biomarkers; Body Weight; Cesarean Section; Chromatog	2014
Pharmacokinetics of hydrocodone/acetaminophen combination product in children ages 6-17 with moderate to moderately severe postoperative pain. Journal of clinical pharmacology, 2015, Volume: 55, Issue:2 Topics: Acetaminophen; Adolescent; Analgesics, Opioid; Area Under Curve; Body Surface Area; Body Weight; Chi	2015
Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants. European journal of clinical pharmacology, 2015, Volume: 71, Issue:9 Topics: Acetaminophen; Body Weight; Child Development; Computer Simulation; Female; Humans; Infant; Infant,	2015
Pooled Post Hoc Analysis of Population Pharmacokinetics of Oxycodone and Acetaminophen Following Multiple Oral Doses of Biphasic Immediate-Release/Extended-Release Oxycodone/Acetaminophen Tablets. Pain practice : the official journal of World Institute of Pain, 2016, Volume: 16, Issue:6 Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Body Weight; Cross-O	2016
Medicine dosing by weight in the home: can parents accurately weigh preschool children? A method comparison study. Archives of disease in childhood, 2011, Volume: 96, Issue:12 Topics: Acetaminophen; Aging; Anthropometry; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Body Wei	2011
Efficacy of superactivated charcoal administered late (3 hours) after acetaminophen overdose. The American journal of emergency medicine, 2003, Volume: 21, Issue:3 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Body Weight; Charcoal; Drug Overdose; Humans; Multiv	2003
Acetaminophen in cerebrospinal fluid in children. European journal of clinical pharmacology, 2003, Volume: 59, Issue:4 Topics: Acetaminophen; Adolescent; Age Factors; Analgesics, Non-Narcotic; Bayes Theorem; Body Weight; Brain	2003
When fever, paracetamol? Theory and practice in a paediatric outpatient clinic. Pharmacy world & science : PWS, 2005, Volume: 27, Issue:3 Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Body Weight; Child, Preschool; Data Colle	2005
Intra- and interindividual variability of glucuronidation of paracetamol during repeated administration of propacetamol in neonates. Acta paediatrica (Oslo, Norway : 1992), 2005, Volume: 94, Issue:9 Topics: Acetaminophen; Age Factors; Analgesics; Body Weight; Chromatography, High Pressure Liquid; Gestation	2005
Paracetamol pharmacokinetics during the first trimester of human pregnancy. European journal of clinical pharmacology, 1994, Volume: 46, Issue:5 Topics: Acetaminophen; Adult; Body Weight; Female; Half-Life; Humans; Pregnancy; Pregnancy Trimester, First	1994
Examination of acetaminophen for outpatient management of postoperative pain in children. Paediatric anaesthesia, 1998, Volume: 8, Issue:3 Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Adolescent; Ambulatory Care; Analgesics	1998
Comments on Migraleve trial reports. Current therapeutic research, clinical and experimental, 1975, Volume: 18, Issue:1 pt 2 Topics: Acetaminophen; Analgesics; Body Weight; Clinical Trials as Topic; Codeine; Drug Combinations; Humans	1975
Single-dose, placebo-controlled comparative study of ibuprofen and acetaminophen antipyresis in children. The Journal of pediatrics, 1991, Volume: 119, Issue:5 Topics: Acetaminophen; Administration, Oral; Anti-Bacterial Agents; Body Temperature; Body Weight; Child; Ch	1991
Migraleve in the prophylaxis of migraine. Current therapeutic research, clinical and experimental, 1974, Volume: 16, Issue:12 Topics: Acetaminophen; Adolescent; Adult; Body Weight; Clinical Trials as Topic; Codeine; Drug Combinations;	1974
Comparison of migraleve and buclizine in prophylaxis of migraine. Current therapeutic research, clinical and experimental, 1974, Volume: 16, Issue:12 Topics: Acetaminophen; Analgesics; Body Weight; Clinical Trials as Topic; Codeine; Drug Combinations; Female	1974

Article	Year
Protective Effect of Fresh/Dry Dandelion Extracts on APAP-Overdose-Induced Acute Liver Injury. Chinese journal of integrative medicine, 2022, Volume: 28, Issue:8 Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; bcl-2-Associated X Protein; Body Weight; Ca	2022
Highly Variable Paracetamol Pharmacokinetics After Multiple Oral Dosing in Frail Older People: A Population Pharmacokinetic Analysis. Drugs & aging, 2022, Volume: 39, Issue:1 Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Bacterial Agents; Body Weight; Frail Elderly; Humans; I	2022
Population Pharmacokinetic Modelling of Acetaminophen and Ibuprofen: the Influence of Body Composition, Formulation and Feeding in Healthy Adult Volunteers. European journal of drug metabolism and pharmacokinetics, 2022, Volume: 47, Issue:4 Topics: Acetaminophen; Administration, Oral; Adult; Biological Availability; Body Composition; Body Weight;	2022
Paracetamol dosing in hospital and on discharge for older people who are frail or have low body weight. British journal of clinical pharmacology, 2022, Volume: 88, Issue:10 Topics: Acetaminophen; Aged; Aged, 80 and over; Body Weight; Frail Elderly; Hospitals; Humans; Patient Disch	2022
Hepatoprotective effects of walnut oil and Caralluma tuberculata against paracetamol in experimentally induced liver toxicity in mice. Acta biochimica Polonica, 2022, Oct-24, Volume: 69, Issue:4 Topics: Acetaminophen; Animals; Apocynaceae; Body Weight; Cholesterol; Creatinine; Juglans; Liver; Methanol;	2022
Nephrocurative Effect of Parthenium hysterophorus (Carrot Grass) in Paracetamol Induced Nephrotoxicity in Rabbits. Cellular and molecular biology (Noisy-le-Grand, France), 2022, Jul-31, Volume: 68, Issue:7 Topics: Acetaminophen; Animals; Body Weight; Male; Methanol; Plant Extracts; Poaceae; Rabbits; Urea	2022
Nephrocurative Effect of Parthenium hysterophorus (Carrot Grass) in Paracetamol Induced Nephrotoxicity in Rabbits. Cellular and molecular biology (Noisy-le-Grand, France), 2022, Jul-31, Volume: 68, Issue:7 Topics: Acetaminophen; Animals; Body Weight; Male; Methanol; Plant Extracts; Poaceae; Rabbits; Urea	2022
Nephrocurative Effect of Parthenium hysterophorus (Carrot Grass) in Paracetamol Induced Nephrotoxicity in Rabbits. Cellular and molecular biology (Noisy-le-Grand, France), 2022, Jul-31, Volume: 68, Issue:7 Topics: Acetaminophen; Animals; Body Weight; Male; Methanol; Plant Extracts; Poaceae; Rabbits; Urea	2022
Nephrocurative Effect of Parthenium hysterophorus (Carrot Grass) in Paracetamol Induced Nephrotoxicity in Rabbits. Cellular and molecular biology (Noisy-le-Grand, France), 2022, Jul-31, Volume: 68, Issue:7 Topics: Acetaminophen; Animals; Body Weight; Male; Methanol; Plant Extracts; Poaceae; Rabbits; Urea	2022
Functional Evaluation for Various Methods of Gastrectomy and Reconstruction for Gastric Cancer. The Tokai journal of experimental and clinical medicine, 2019, Dec-20, Volume: 44, Issue:4 Topics: Acetaminophen; Aged; Body Weight; Eating; Female; Gastrectomy; Humans; Intestinal Absorption; Intest	2019
Functional evaluations comparing the double-tract method and the jejunal interposition method following laparoscopic proximal gastrectomy for gastric cancer: an investigation including laparoscopic total gastrectomy. Surgery today, 2019, Volume: 49, Issue:1 Topics: Acetaminophen; Aged; Body Weight; Female; Gastrectomy; Gastrins; Humans; Insulin; Intestinal Absorpt	2019
Population Pharmacokinetic Modeling of Acetaminophen and Metabolites in Children After Cardiac Surgery With Cardiopulmonary Bypass. Journal of clinical pharmacology, 2019, Volume: 59, Issue:6 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Biological Variation, Populati	2019
Acetaminophen aggravates fat accumulation in NAFLD by inhibiting autophagy via the AMPK/mTOR pathway. European journal of pharmacology, 2019, May-05, Volume: 850 Topics: Acetaminophen; Adipose Tissue; AMP-Activated Protein Kinases; Animals; Autophagosomes; Autophagy; Bo	2019
Population Pharmacokinetic Modeling in the Presence of Missing Time-Dependent Covariates: Impact of Body Weight on Pharmacokinetics of Paracetamol in Neonates. The AAPS journal, 2019, 05-28, Volume: 21, Issue:4 Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Weight; Drug Dosage Calculations; Humans; Infant, Newb	2019
Therapeutic effect of liposomal-N-acetylcysteine against acetaminophen-induced hepatotoxicity. Journal of drug targeting, 2013, Volume: 21, Issue:5 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin	2013
Introduction of an N-acetylcysteine weight-based dosing chart reduces prescription errors in the treatment of paracetamol poisoning: Reply. Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Body Weight; Drug Dosage Calculations; Fema	2013
Response to Introduction of an N-acetylcysteine weight-based dosing chart reduces prescription errors in the treatment of paracetamol poisoning: Reply. Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Body Weight; Drug Dosage Calculations; Fema	2013
Parental language and dosing errors after discharge from the pediatric emergency department. Pediatric emergency care, 2013, Volume: 29, Issue:9 Topics: Acetaminophen; Adult; Body Weight; Boston; Child; Child Health Services; Child, Preschool; Communica	2013
Overdosed paracetamol (acetaminophen) prescriptions and subsequent pharmacist interventions in French hospitals. Annales pharmaceutiques francaises, 2013, Volume: 71, Issue:6 Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Weight; Drug Overdose; France; Humans; Medication Erro	2013
[Intravenous paracetamol in the neonate and infant less than 10kg]. Annales francaises d'anesthesie et de reanimation, 2014, Volume: 33, Issue:3 Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Weight; Humans; Infant; Infant, Newborn; Injections, I	2014
[Intravenous paracetamol in the neonate and infant less than 10 kg]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2014, Volume: 21, Issue:9 Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Weight; Dose-Response Relationship, Drug; Humans; Infa	2014
Weight, pregnancy and oral contraceptives affect intravenous paracetamol clearance in young women. European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:5 Topics: Acetaminophen; Administration, Intravenous; Adult; Analgesics, Non-Narcotic; Body Weight; Cohort Stu	2014
Sub-acute toxicity studies of acetaminophen in Sprague Dawley rats. Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:7 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Body Weight; Dose-Response Relationship, Drug; Eat	2014
Artemisia pallens alleviates acetaminophen induced toxicity via modulation of endogenous biomarkers. Pharmaceutical biology, 2015, Volume: 53, Issue:4 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Artemisia; Biomarkers; Body Weight; Dose-Response	2015
Postmarketing review of intravenous acetaminophen dosing based on Food and Drug Administration prescribing guidelines. Pharmacotherapy, 2014, Volume: 34 Suppl 1 Topics: Acetaminophen; Administration, Intravenous; Adult; Analgesics, Non-Narcotic; Body Weight; Drug Presc	2014
An accidental overdose of N-acetylcysteine during treatment for acetaminophen toxicity. Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:5 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Body Weight; Drug Dosage Calcula	2015
Population Pharmacokinetics of Intravenous Paracetamol (Acetaminophen) in Preterm and Term Neonates: Model Development and External Evaluation. Clinical pharmacokinetics, 2016, Volume: 55, Issue:1 Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Body Weight; Drug Dosage Calcu	2016
[Good use and knowledge of paracetamol (acetaminophen) among self-medicated patients: Prospective study in community pharmacies]. Therapie, 2016, Volume: 71, Issue:3 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Body Weight; Chemical and Drug Induced Liver Injury;	2016
Evaluation of a single-dose PIGRET assay for acetaminophen in rats compared with the RBC Pig-a assay. Mutation research. Genetic toxicology and environmental mutagenesis, 2016, Nov-15, Volume: 811 Topics: Acetaminophen; Animals; Body Weight; Dose-Response Relationship, Drug; Erythrocytes; Membrane Protei	2016
Polyphenols rich Passiflora leschenaultii leaves modulating Farnesoid X Receptor and Pregnane X Receptor against paracetamol-induced hepatotoxicity in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 88 Topics: Acetaminophen; Animals; Antioxidants; Biomarkers; Body Weight; Liver Diseases; Male; Molecular Docki	2017
[Therapy refractory hypertension]. Praxis, 2008, Apr-30, Volume: 97, Issue:9 Topics: Acetaminophen; Adrenal Gland Neoplasms; Adult; Analgesics, Non-Narcotic; Antihypertensive Agents; Bo	2008
I.V. acetaminophen pharmacokinetics in neonates after multiple doses. British journal of anaesthesia, 2008, Volume: 101, Issue:4 Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Weight; Female; Gestational Age; Humans; Hyperbilirubi	2008
Effects of choline-deprivation on paracetamol- or phenobarbital-induced rat liver metabolic response. Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:2 Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Aspart	2009
Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver. Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:9 Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Animals; ATP Binding Cassette Transporter, Subf	2009
Acetaminophen as a postsurgical analgesic in rats: a practical solution to neophobia. Contemporary topics in laboratory animal science, 2003, Volume: 42, Issue:2 Topics: Acetaminophen; Administration, Oral; Analgesia; Analgesics, Non-Narcotic; Animals; Behavior, Animal;	2003
Toxicodynamics of subacute co-exposure to groundwater contaminant arsenic and analgesic-antipyretic drug acetaminophen in rats. Ecotoxicology and environmental safety, 2010, Volume: 73, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arsenic; Body Weight; Cytochrome P-450 Enzyme Syst	2010
Management of fever in children: summary of the Italian Pediatric Society guidelines. Clinical therapeutics, 2009, Volume: 31, Issue:8 Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Axilla; Body Temperature; Body Weight; Child;	2009
The effect of the aqueous extract of Kohautia grandiflora on paracetamol-induced liver damage in albino rats. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2009, Volume: 24, Issue:1 Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil	2009
Acetaminophen combinations protect against iron-induced cardiac damage in gerbils. Annals of clinical and laboratory science, 2009,Fall, Volume: 39, Issue:4 Topics: Acetaminophen; Animals; Arrhythmias, Cardiac; Body Weight; Cardiotonic Agents; Electrocardiography;	2009
Effect of a weight-based prescribing method within an electronic health record on prescribing errors. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2009, Nov-15, Volume: 66, Issue:22 Topics: Acetaminophen; Ambulatory Care; Analgesics, Non-Narcotic; Body Weight; Child; Child, Preschool; Dose	2009
Protection from olanzapine-induced metabolic toxicity in mice by acetaminophen and tetrahydroindenoindole. International journal of obesity (2005), 2010, Volume: 34, Issue:6 Topics: Acetaminophen; Adipose Tissue; Adipose Tissue, White; Animals; Antioxidants; Antipsychotic Agents; B	2010
A 4-week oral toxicity study of an antiviral drug combination consisting of arbidol and acetaminophen in rats. Drug and chemical toxicology, 2010, Volume: 33, Issue:3 Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antiviral Agents; Blood Cell	2010
Temporal study of acetaminophen (APAP) and S-adenosyl-L-methionine (SAMe) effects on subcellular hepatic SAMe levels and methionine adenosyltransferase (MAT) expression and activity. Toxicology and applied pharmacology, 2010, Aug-15, Volume: 247, Issue:1 Topics: Acetaminophen; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Drug Interactions; Intr	2010
The pharmacokinetics of intravenous paracetamol in neonates: size matters most. Archives of disease in childhood, 2011, Volume: 96, Issue:6 Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Weight; Drug Administration Schedule; Gestational Age;	2011
Acetaminophen-induced forestomach lesion in normal rats following intravenous exposure. Toxicologic pathology, 2011, Volume: 39, Issue:5 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Body Weight; Drug Contamination; Female; Gastric M	2011
British National Formulary for Children: the risk of inappropriate paracetamol prescribing. Archives of disease in childhood, 2012, Volume: 97, Issue:3 Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Antipyretics; Body Weight; Child; Child, Presc	2012
Population pharmacokinetics of single-dose intravenous paracetamol in children. British journal of anaesthesia, 2012, Volume: 108, Issue:5 Topics: Acetaminophen; Adolescent; Aging; Analgesics, Non-Narcotic; Anesthesia, General; Blood Specimen Coll	2012
Proposed MHRA changes to UK children's paracetamol dosing recommendations: modelling study. Journal of the Royal Society of Medicine, 2012, Volume: 105, Issue:6 Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Weight; Child; Child, Preschool; Delivery of Health Ca	2012
Introduction of an N-acetylcysteine weight-based dosing chart reduces prescription errors in the treatment of paracetamol poisoning. Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Australia; Body Weight; Drug Dosage	2013
Paracetamol and ketorolac pharmacokinetics and metabolism at delivery and during postpartum. Acta anaesthesiologica Belgica, 2012, Volume: 63, Issue:3 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Biotransfor	2012
Glycosmis arborea extract as a hepatoprotective agent. Phytotherapy research : PTR, 2003, Volume: 17, Issue:5 Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Body Weight; Carbon Tetrachlorid	2003
THE RENAL CONCENTRATING CAPACITY IN ALBINO RATS AFTER LONG-TERM CONSUMPTION OF PHENACETIN, NAPA (N-ACETYL-P-AMINOPHENOL) AND ACETYLSALICYLIC ACID. Acta medica Scandinavica, 1964, Volume: 175 Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Body Weight; Erythrocyte	1964
Intravenous paracetamol (propacetamol) pharmacokinetics in term and preterm neonates. European journal of clinical pharmacology, 2004, Volume: 60, Issue:3 Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Body Weight; Clinical Trials as Topic; Drug Ad	2004
Acetaminophen dose accuracy and pediatric emergency care. Pediatric emergency care, 2004, Volume: 20, Issue:5 Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Analgesics, Non-Narcotic; Anti-Inflamma	2004
Differences in the single-oral-dose pharmacokinetics and urinary excretion of paracetamol and its conjugates between Hong Kong Chinese and Caucasian subjects. Journal of clinical pharmacy and therapeutics, 2005, Volume: 30, Issue:2 Topics: Acetaminophen; Administration, Oral; Adult; Area Under Curve; Asian People; Body Height; Body Weight	2005
Fever control in septic shock: beneficial or harmful? Shock (Augusta, Ga.), 2005, Volume: 23, Issue:6 Topics: Acetaminophen; Animals; Body Temperature; Body Weight; Female; Fever; HSP70 Heat-Shock Proteins; Iso	2005
Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging cell, 2005, Volume: 4, Issue:3 Topics: Acetaminophen; Aging; Alanine Transaminase; Animals; Blood Glucose; Body Weight; Cataract; Diet; Ene	2005
Adverse drug reactions to nonsteroidal anti-inflammatory drugs, COX-2 inhibitors and paracetamol in a paediatric hospital. British journal of clinical pharmacology, 2005, Volume: 59, Issue:6 Topics: Acetaminophen; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcotic;	2005
New recommendation for N-acetylcystiene dosing may reduce incidence of adverse effects. Emergency medicine journal : EMJ, 2006, Volume: 23, Issue:7 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Body Weight; Drug Overdose; Huma	2006
Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity. The Biochemical journal, 2006, Nov-01, Volume: 399, Issue:3 Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Biotransformation; Body Weight; Cytochr	2006
Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study. Clinical therapeutics, 2006, Volume: 28, Issue:5 Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid	2006
Acetaminophen protects against iron-induced cardiac damage in gerbils. Annals of clinical and laboratory science, 2007,Winter, Volume: 37, Issue:1 Topics: Acetaminophen; Administration, Oral; Analysis of Variance; Animals; Body Weight; Echocardiography; G	2007
Paediatric analgesia in the emergency department, are we getting it right? European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2007, Volume: 14, Issue:3 Topics: Acetaminophen; Age Factors; Analgesia; Analgesics, Non-Narcotic; Body Weight; Child; Child, Preschoo	2007
Overlapping gene expression profiles of model compounds provide opportunities for immunotoxicity screening. Toxicology and applied pharmacology, 2008, Jan-01, Volume: 226, Issue:1 Topics: Acetaminophen; Animals; Benzo(a)pyrene; Body Weight; Cell Cycle; Cyclosporine; Gene Expression Profi	2008
Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2007, Volume: 16, Issue:6 Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Antineoplastic Agents; Body Weight; Carcinoma, Hepato	2007
Assessment of drugs in out-patients with rheumatoid arthritis. Evaluation of methods and a comparison of mefenamic and flufenamic acids with phenylbutazone and aspirin. Annals of the rheumatic diseases, 1967, Volume: 26, Issue:5 Topics: Acetaminophen; Adult; Agglutination Tests; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin;	1967
Modification of carcinogenesis by antioxidants and other compounds. Acta pharmacologica et toxicologica, 1984, Volume: 55 Suppl 2 Topics: Acetaminophen; Animals; Antioxidants; Body Weight; Butylated Hydroxyanisole; Carcinogens; Diethylnit	1984
Effects of dietary methionine and ethanol on acetaminophen hepatotoxicity in mice. Drug-nutrient interactions, 1984, Volume: 3, Issue:1 Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Body Weight; Diet; Ethanol; Glutathione; Glutat	1984
Hepatotoxicity and metabolism of acetaminophen in male and female rats. Journal of toxicology and environmental health, 1983, Volume: 12, Issue:1 Topics: Acetaminophen; Animals; Body Weight; Castration; Female; Glutathione; Kinetics; Liver; Liver Glycoge	1983
Increased acetaminophen-induced hepatotoxicity after chronic ethanol consumption in mice. Toxicology, 1983, Volume: 28, Issue:3 Topics: Acetaminophen; Animals; Body Weight; Drug Synergism; Ethanol; Glutathione; Hemoglobins; Liver; Male;	1983
Pediatric dosing of acetaminophen. Pediatric pharmacology (New York, N.Y.), 1983, Volume: 3, Issue:3-4 Topics: Acetaminophen; Age Factors; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug;	1983
Effect of riboflavin status on acetaminophen toxicity in the rat. Drug-nutrient interactions, 1983, Volume: 2, Issue:3 Topics: Acetaminophen; Animals; Body Weight; Diet; Liver; Liver Glycogen; Male; Organ Size; Rats; Rats, Inbr	1983
Hepatotoxicity of acetaminophen in neonatal and young rats. I. Age-related changes in susceptibility. Toxicology and applied pharmacology, 1984, Jun-15, Volume: 74, Issue:1 Topics: Acetaminophen; Age Factors; Alanine Transaminase; Animals; Animals, Newborn; Body Weight; Bromobenze	1984
Increased metabolic clearance of acetaminophen with oral contraceptive use. Obstetrics and gynecology, 1982, Volume: 60, Issue:3 Topics: Acetaminophen; Adult; Body Weight; Contraceptives, Oral; Contraceptives, Oral, Hormonal; Drug Intera	1982
Obesity, sex, and acetaminophen disposition. Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:6 Topics: Acetaminophen; Adult; Aged; Body Weight; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged	1982
Protective effect of testosterone against alcohol and paracetamol induced hepatotoxicity in rats. Indian journal of experimental biology, 1995, Volume: 33, Issue:3 Topics: Acetaminophen; Animals; Body Weight; Eating; Ethanol; Lipid Metabolism; Liver; Male; Rats; Rats, Spr	1995
Cytochrome P450 and glutathione in the liver of rats under exclusive sucrose ingestion. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1993, Volume: 26, Issue:9 Topics: Acetaminophen; Animals; Antipyrine; Body Weight; Cholesterol Side-Chain Cleavage Enzyme; Fasting; Gl	1993
Studies on the chronic oral toxicity of an analgesic drug combination consisting of acetylsalicylic acid, paracetamol and caffeine in rats including an electron microscopical evaluation of kidneys. Arzneimittel-Forschung, 1996, Volume: 46, Issue:9 Topics: Acetaminophen; Analgesics; Animals; Aspirin; Blood Cell Count; Body Weight; Caffeine; Central Nervou	1996
Paracetamol prescribing habits in a children's hospital. The New Zealand medical journal, 1996, Oct-11, Volume: 109, Issue:1031 Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Body Weight; Drug Utilization; Hospital Bed Ca	1996
Changes in protein turnover and resting energy expenditure after treatment of malaria in Gambian children. Pediatric research, 1996, Volume: 39, Issue:3 Topics: Acetaminophen; Adolescent; Body Mass Index; Body Temperature; Body Weight; Child; Chloroquine; Energ	1996
Reproductive toxicology. Acetaminophen. Environmental health perspectives, 1997, Volume: 105 Suppl 1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Birth Weight; Body Weight; Dose-Response Relations	1997
Apparent antinociceptive and anti-inflammatory effects of GYKI 52466. European journal of pharmacology, 1997, Oct-08, Volume: 336, Issue:2-3 Topics: Acetaminophen; Analgesics; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents; Arthritis, Experi	1997
The effect of chronic retrovirus infection and immune dysfunction on the P-450-mediated activation of acetaminophen in mouse liver microsomes. Biopharmaceutics & drug disposition, 1998, Volume: 19, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Body Weight; Cytochrome P-450 E	1998
The ageing entero-insular axis. Diabetologia, 1998, Volume: 41, Issue:11 Topics: Acetaminophen; Adult; Aged; Aging; Blood Glucose; Body Mass Index; Body Weight; Diabetes Mellitus, T	1998
Acetaminophen effects on behavioral thermoregulation in albino rats. Perceptual and motor skills, 1999, Volume: 88, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin;	1999
Predicting concentrations in children presenting with acetaminophen overdose. The Journal of pediatrics, 1999, Volume: 135, Issue:3 Topics: Acetaminophen; Adult; Age Factors; Analgesics, Non-Narcotic; Antidotes; Body Weight; Charcoal; Child	1999
Plasma paracetamol concentrations and pharmacokinetics following rectal administration in neonates and young infants. Acta anaesthesiologica Scandinavica, 1999, Volume: 43, Issue:8 Topics: Absorption; Acetaminophen; Administration, Rectal; Analgesics, Non-Narcotic; Anesthesia, General; An	1999
Repeated acetaminophen dosing in rats: adaptation of hepatic antioxidant system. Human & experimental toxicology, 2000, Volume: 19, Issue:5 Topics: Acetaminophen; Adaptation, Physiological; Alanine Transaminase; Animals; Antioxidants; Body Weight;	2000
Gastric emptying in diabetic gastroparetic dogs: ffects of SK-951,a novel prokinetic agent. Pharmacology, 2001, Volume: 62, Issue:1 Topics: Acetaminophen; Animals; Benzofurans; Blood Glucose; Body Weight; Bridged Bicyclo Compounds, Heterocy	2001
Long-term administration of large doses of paracetamol impairs the reproductive competence of male rats. Asian journal of andrology, 2000, Volume: 2, Issue:4 Topics: Acetaminophen; Animals; Body Weight; Contraceptive Agents, Male; Dose-Response Relationship, Drug; D	2000
Potentiation of the immunotoxicity of ethanol by acetaminophen in mice. International immunopharmacology, 2002, Volume: 2, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Body Weight; Central Nervous System Depressants; D	2002
Combined effects of acetaminophen, isopropylantipyrine and caffeine on pregnant and nonpregnant liver. Human & experimental toxicology, 2001, Volume: 20, Issue:11 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrin	2001
Embryofetotoxicity of acetaminophen (paracetamol) in experimental in vivo model. Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina, 2001, Volume: 56 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Body Weight; Dose-Response Relationship, Drug; Ecc	2001
Failure to observe pathology in the rat following chronic dosing with acetaminophen and acetylsalicylic acid. Research communications in chemical pathology and pharmacology, 1977, Volume: 17, Issue:4 Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Asp	1977
Experimental renal papillary necrosis. Kidney international, 1978, Volume: 13, Issue:1 Topics: Acetaminophen; Animals; Aspirin; Body Weight; Drug Combinations; Female; Kidney Cortex; Kidney Medul	1978
Mechanisms of the inhibitory action of p-hydroxyacetanilide on carcinogenesis by N-2-fluorenylacetamide or N-hydroxy-N-2-fluorenylacetamide. Journal of the National Cancer Institute, 1976, Volume: 56, Issue:4 Topics: 2-Acetylaminofluorene; Acetaminophen; Amidohydrolases; Animals; Body Weight; Eating; Feces; Fluorene	1976
Effects of aspirin and acetaminophen on fetal and placental growth in rats. Journal of pharmaceutical sciences, 1977, Volume: 66, Issue:1 Topics: Acetaminophen; Animals; Aspirin; Body Weight; Female; Fetus; Placenta; Pregnancy; Rats	1977
Serum enzyme activities and hepatic triglyceride levels in acute and subacute acetaminophen-treated rats. Toxicology, 1976, Volume: 6, Issue:1 Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Hexobarbital	1976
The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures. Biochemical pharmacology, 1975, Jan-01, Volume: 24, Issue:1 Topics: Acetaminophen; Animals; Body Weight; Caseins; Chemical and Drug Induced Liver Injury; Cysteine; Cyto	1975
Pharmacokinetics of acetaminophen in the human neonate: formation of acetaminophen glucuronide and sulfate in relation to plasma bilirubin concentration and D-glucaric acid excretion. Pediatrics, 1975, Volume: 55, Issue:6 Topics: Acetaminophen; Adipates; Age Factors; Bilirubin; Body Weight; Female; Glucuronates; Half-Life; Human	1975
Purging with paracetamol: report of four cases. BMJ (Clinical research ed.), 1992, Sep-12, Volume: 305, Issue:6854 Topics: Acetaminophen; Adolescent; Adult; Body Image; Body Weight; Bulimia; Female; Humans; Nausea; Substanc	1992
The effects of iodinated glycerol, trichlorfon, and acetaminophen on tumor progression in a Fischer rat leukemia transplant model. Cancer detection and prevention, 1992, Volume: 16, Issue:3 Topics: Acetaminophen; Animals; Body Weight; Carcinogenicity Tests; Disease Models, Animal; Expectorants; Fe	1992
Reproductive toxicity evaluation of acetaminophen in Swiss CD-1 mice using a continuous breeding protocol. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1992, Volume: 18, Issue:2 Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Birth Weight; Body Weight; Breeding; Dose-Respo	1992
Drug clearance in patients with cystic fibrosis. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:1 Topics: Acetaminophen; Body Surface Area; Body Weight; Cystic Fibrosis; Humans; Metabolic Clearance Rate	1992
Acetaminophen-induced depletion of glutathione and cysteine in the aging mouse kidney. Biochemical pharmacology, 1992, Jul-07, Volume: 44, Issue:1 Topics: Acetaminophen; Acetylcysteine; Aging; Animals; Body Weight; Cysteine; Cystine; Dose-Response Relatio	1992
Potentiation of acute acetaminophen lethality by selenium and vitamin E deficiency in mice. The Journal of nutrition, 1992, Volume: 122, Issue:1 Topics: Acetaminophen; Animals; Body Weight; Drug Synergism; Lethal Dose 50; Liver; Male; Methionine; Mice;	1992
Effects of long-term administration of acetaminophen on the nutritional utilization of dietary protein. Annals of nutrition & metabolism, 1991, Volume: 35, Issue:5 Topics: Acetaminophen; Animals; Body Weight; Dietary Fats; Dietary Proteins; Digestion; Eating; Female; Live	1991
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine. Japanese journal of cancer research : Gann, 1991, Volume: 82, Issue:3 Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; D	1991
Appropriate dosage of acetominophen for infants. Journal of emergency nursing, 1991, Volume: 17, Issue:3 Topics: Acetaminophen; Body Weight; Fever; Humans; Infant; Infant, Newborn; Reference Books, Medical	1991
Effects of ibuprofen on doxorubicin toxicity. Research communications in chemical pathology and pharmacology, 1990, Volume: 67, Issue:1 Topics: Acetaminophen; Actomyosin; Adenosine Triphosphatases; Animals; Anti-Inflammatory Agents, Non-Steroid	1990
Lack of hepatocarcinogenic potential of acetaminophen in rats with liver damage associated with a choline-devoid diet. Carcinogenesis, 1990, Volume: 11, Issue:6 Topics: Acetaminophen; Animals; Body Weight; Carcinogens; Choline Deficiency; Diethylnitrosamine; Female; Gl	1990
Experimental analgesic nephropathy: changes in renal structure and urinary concentrating ability in Fischer 344 rats given continuous low doses of aspirin and paracetamol. Pathology, 1990, Volume: 22, Issue:1 Topics: Acetaminophen; Animals; Aspirin; Body Weight; Disease Models, Animal; Female; Kidney Concentrating A	1990
Impaired mitochondrial oxidative energy metabolism following paracetamol-induced hepatotoxicity in the rat. British journal of pharmacology, 1989, Volume: 96, Issue:1 Topics: Acetaminophen; Adenosine Triphosphatases; Animals; Body Weight; Cytochromes; Energy Metabolism; Live	1989
Prolonged acetaminophen ingestion in mice: effects on the availability of methionine for metabolic functions. The Journal of nutrition, 1989, Volume: 119, Issue:7 Topics: Acetaminophen; Animals; Body Weight; Cysteine; Glutathione; Liver; Male; Methionine; Mice; Nutritive	1989
Inhibitory potential of acetaminophen and o-, m-, p- aminophenols for development of gamma-glutamyltranspeptidase-positive liver cell foci in rats pretreated with diethylnitrosamine. Cancer letters, 1985, Volume: 28, Issue:1 Topics: Acetaminophen; Aminophenols; Animals; Body Weight; Diethylnitrosamine; gamma-Glutamyltransferase; Li	1985
Inhibitory effects of ethoxyquin, 4,4'-diaminodiphenylmethane and acetaminophen on rat hepatocarcinogenesis. Japanese journal of cancer research : Gann, 1986, Volume: 77, Issue:3 Topics: 2-Acetylaminofluorene; Acetaminophen; Aniline Compounds; Animals; Body Weight; Butylated Hydroxyanis	1986
Acetaminophen hepatotoxicity in aging rats. Drug and chemical toxicology, 1988, Volume: 11, Issue:3 Topics: Acetaminophen; Aging; Alanine Transaminase; Animals; Body Weight; Chemical and Drug Induced Liver In	1988
Hepatotoxicity of chronic high dose administration of acetaminophen to mice. A critical review and implications for hazard assessment. Archives of toxicology, 1988, Volume: 62, Issue:6 Topics: Acetaminophen; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Female; Liver; Male; Mi	1988
Influence of ascorbic acid esters on acetaminophen-induced hepatotoxicity in mice. Toxicology letters, 1988, Volume: 44, Issue:1-2 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Body Weight; Drug Th	1988
Study for tumor-initiating effect of acetaminophen in two-stage liver carcinogenesis of male F344 rats. Carcinogenesis, 1988, Volume: 9, Issue:5 Topics: Acetaminophen; Animals; Body Weight; Cocarcinogenesis; DNA; Glutathione Transferase; Liver; Liver Ne	1988
Long-term administration of toxic doses of paracetamol (acetaminophen) to rats. Liver, 1988, Volume: 8, Issue:3 Topics: Acetaminophen; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Female; Liver; Liver Fu	1988
Effects of methionine deficiency and ethanol ingestion on acetaminophen metabolism in mice. The Journal of nutrition, 1987, Volume: 117, Issue:3 Topics: Acetaminophen; Acetylcysteine; Aniline Hydroxylase; Animals; Body Weight; Diet; Ethanol; Glutathione	1987
Time development of distribution and toxicity following single toxic APAP doses in male BOM:NMRI mice. Journal of applied toxicology : JAT, 1987, Volume: 7, Issue:1 Topics: Acetaminophen; Animals; Autoradiography; Body Weight; Chemical and Drug Induced Liver Injury; Glutat	1987
Reciprocal modifying effects of isomeric forms of aminophenol on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine. Carcinogenesis, 1987, Volume: 8, Issue:9 Topics: Acetaminophen; Aminophenols; Animals; Body Weight; Diethylnitrosamine; Glutathione Transferase; Kidn	1987
Underdosing of acetaminophen by parents. Pediatrics, 1987, Volume: 80, Issue:5 Topics: Acetaminophen; Age Factors; Body Weight; Child, Preschool; Fever; Humans; Infant; Medication Errors;	1987
The chronic hepatotoxic, tumor-promoting, and carcinogenic effects of acetaminophen in male B6C3F1 mice. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1986, Volume: 7, Issue:3 Topics: Acetaminophen; Animals; Body Weight; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnit	1986
Disposition of acetaminophen in protein-calorie malnutrition. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:1 Topics: Acetaminophen; Animals; Blood Proteins; Body Weight; Dietary Proteins; Disease Models, Animal; Eatin	1985
Carcinogenicity testing of acetaminophen in F344 rats. Japanese journal of cancer research : Gann, 1985, Volume: 76, Issue:2 Topics: Acetaminophen; Animals; Body Weight; Carcinogens; Female; Male; Neoplasms, Experimental; Rats; Rats,	1985
Studies on the effect of chronic consumption of moderate amounts of ethanol on male rat hepatic microsomal drug-metabolizing activity. Biochemical pharmacology, 1985, Oct-01, Volume: 34, Issue:19 Topics: Acetaminophen; Alanine Transaminase; Aniline Hydroxylase; Animals; Aspartate Aminotransferases; Body	1985
Postabsorption antidotal effects of N-acetylcysteine on acetaminophen-induced hepatotoxicity in the mouse. Canadian journal of physiology and pharmacology, 1985, Volume: 63, Issue:5 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile; Bod	1985
Subchronic and chronic effects of feeding of large amounts of acetaminophen in B6C3F1 mice. Nihon eiseigaku zasshi. Japanese journal of hygiene, 1985, Volume: 40, Issue:2 Topics: Acetaminophen; Administration, Oral; Animals; Body Weight; Female; Liver; Male; Mice; Mice, Inbred S	1985
Acute toxicity and analgesic action of a combination of buclizine, codeine and paracetamol ('Migraleve') in tablet and suppository form in rats. Pharmatherapeutica, 1985, Volume: 4, Issue:5 Topics: Acetaminophen; Analgesics; Animals; Body Temperature; Body Weight; Codeine; Drug Combinations; Elect	1985
The role of p-aminophenol in acetaminophen-induced nephrotoxicity: effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats. Toxicology and applied pharmacology, 1985, Volume: 81, Issue:3 Pt 1 Topics: Acetaminophen; Aminophenols; Animals; Body Weight; Injections, Intraperitoneal; Kidney Cortex Necros	1985
Interactions of aspirin, indomethacin and other drugs in adjuvant-induced arthritis in the rat. The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:2 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Body Weight; Chlorpromazine; C	1973
Effects of various drugs on longevity in female C57BL-6J mice. Gerontologia, 1973, Volume: 19, Issue:5 Topics: Acetaminophen; Age Factors; Analgesics; Animals; Aspirin; Body Weight; Buffers; Cell Membrane; Chemi	1973
General and renal toxicity of phenacetin, paracetamol and some anti-mitotic agents in the rat. Archiv fur Toxikologie, 1972, Volume: 28, Issue:4 Topics: Acetaminophen; Anemia, Macrocytic; Anilides; Animals; Blood; Blood Glucose; Body Weight; Caffeine; D	1972
Gas-liquid chromatography of N-acetyl-p-aminophenol (paracetamol) in plasma and urine. Journal of chromatography, 1971, Jul-22, Volume: 59, Issue:2 Topics: Acetaminophen; Adult; Body Weight; Chromatography, Gas; Female; Humans; Male; Methods; Time Factors	1971
The chronic oral toxicity of paracetamol at the range of the LD50 (100 days) in albino rats. Canadian journal of physiology and pharmacology, 1968, Volume: 46, Issue:2 Topics: Acetaminophen; Animals; Anorexia Nervosa; Body Weight; Brain; Diuresis; Dyspnea; Growth; Humans; Hyp	1968
Stimulatory effect of paracetamol on chicken growth. Poultry science, 1966, Volume: 45, Issue:4 Topics: Acetaminophen; Animals; Body Weight; Diet; Growth Hormone; Poultry	1966
Dose-response changes in organ weights and water contents following administration of toxic doses of paracetamol. British journal of pharmacology and chemotherapy, 1966, Volume: 27, Issue:3 Topics: Acetaminophen; Animals; Body Fluids; Body Weight; Organ Size; Rats	1966

acetaminophen and Body Weight