acetaminophen has been researched along with Blood Poisoning in 38 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This trial evaluated the efficacy of acetaminophen in reducing oxidative injury, as measured by plasma F2-isoprostanes, in adult patients with severe sepsis and detectable plasma cell-free hemoglobin." | 9.20 | Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial. ( Bastarache, JA; Bernard, GR; Janz, DR; Oates, JA; Rice, TW; Roberts, LJ; Sills, G; Ware, LB; Warren, MA; Wickersham, N, 2015) |
| "To determine the association of circulating cell-free hemoglobin with poor clinical outcomes in patients with sepsis and to characterize the potential protective effects of acetaminophen, an inhibitor of hemoprotein-mediated oxidation." | 7.79 | Association between cell-free hemoglobin, acetaminophen, and mortality in patients with sepsis: an observational study. ( Bastarache, JA; Janz, DR; May, AK; Peterson, JF; Roberts, LJ; Sills, G; Ware, LB; Wickersham, N, 2013) |
| "Acetaminophen (APAP) has been shown to inhibit lipid peroxidation and, thus, may be renal protective in patients with sepsis." | 5.48 | Effect of Acetaminophen on the Prevention of Acute Kidney Injury in Patients With Sepsis. ( Aljuhani, O; Bakhsh, H; Erstad, BL; Patanwala, AE, 2018) |
| "This trial evaluated the efficacy of acetaminophen in reducing oxidative injury, as measured by plasma F2-isoprostanes, in adult patients with severe sepsis and detectable plasma cell-free hemoglobin." | 5.20 | Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial. ( Bastarache, JA; Bernard, GR; Janz, DR; Oates, JA; Rice, TW; Roberts, LJ; Sills, G; Ware, LB; Warren, MA; Wickersham, N, 2015) |
| "Male gender, chorioamnionitis, early sepsis, asphyxia, hemodynamic PDA, persistent hypotension, ibuprofen and paracetamol usage, and orogastric catheter administration were the main risk factors for gastric perforations in VLBW infants." | 3.88 | Neonatal gastric perforations in very low birth weight infants: a single center experience and review of the literature. ( Babayigit, A; Cetinkaya, M; Ozaydın, S; Sander, S, 2018) |
| "To determine the association of circulating cell-free hemoglobin with poor clinical outcomes in patients with sepsis and to characterize the potential protective effects of acetaminophen, an inhibitor of hemoprotein-mediated oxidation." | 3.79 | Association between cell-free hemoglobin, acetaminophen, and mortality in patients with sepsis: an observational study. ( Bastarache, JA; Janz, DR; May, AK; Peterson, JF; Roberts, LJ; Sills, G; Ware, LB; Wickersham, N, 2013) |
| "To investigate the effect of intravenous propacetamol, a parenteral bioprecursor of acetaminophen, on systemic blood pressure in critically ill patients with fever, and to establish the prevalence and clinical significance of this effect." | 3.74 | Effect of intravenous propacetamol on blood pressure in febrile critically ill patients. ( Hersch, M; Izbicki, G; Raveh, D, 2008) |
| "Sepsis is a heterogeneous clinical syndrome that is complicated commonly by acute kidney injury (sepsis-AKI)." | 2.66 | The Role of Circulating Cell-Free Hemoglobin in Sepsis-Associated Acute Kidney Injury. ( Kerchberger, VE; Ware, LB, 2020) |
| "Induction of fever is mediated by the release of pyrogenic cytokines (tumor necrosis factor α, interleukin 1, interleukin 6, and interferons)." | 2.55 | Paracetamol in fever in critically ill patients-an update. ( Chiumello, D; Gotti, M; Vergani, G, 2017) |
| "Sepsis and acute liver failure are associated with severe endogenous intoxication." | 1.72 | Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study. ( Hayden, MR; Shulyatnikova, T; Tumanskyi, V, 2022) |
| "Acetaminophen (APAP) has been shown to inhibit lipid peroxidation and, thus, may be renal protective in patients with sepsis." | 1.48 | Effect of Acetaminophen on the Prevention of Acute Kidney Injury in Patients With Sepsis. ( Aljuhani, O; Bakhsh, H; Erstad, BL; Patanwala, AE, 2018) |
| "Subsequent testing following treatment of the sepsis revealed no ongoing 5-oxoprolinuria." | 1.42 | Transient 5-oxoprolinuria: unusually high anion gap acidosis in an infant. ( Hulley, SL; Manning, N; Olpin, S; Perring, J; Yap, S, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (15.79) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (13.16) | 29.6817 |
| 2010's | 20 (52.63) | 24.3611 |
| 2020's | 7 (18.42) | 2.80 |
| Authors | Studies |
|---|---|
| Shulyatnikova, T | 3 |
| Tumanskyi, V | 3 |
| Hayden, MR | 3 |
| Scorcella, C | 1 |
| Domizi, R | 1 |
| Amoroso, S | 1 |
| Carsetti, A | 1 |
| Casarotta, E | 1 |
| Castaldo, P | 1 |
| D'angelo, C | 1 |
| Damiani, E | 1 |
| Gasparri, F | 1 |
| Donati, A | 1 |
| Adrario, E | 1 |
| Chu, J | 1 |
| Li, H | 1 |
| Yuan, Z | 1 |
| Zhou, W | 1 |
| Yu, Y | 2 |
| Zheng, Y | 1 |
| Wang, J | 1 |
| Ling, Z | 1 |
| Zhang, J | 1 |
| Zeng, Y | 1 |
| Wang, K | 1 |
| Zhang, Y | 1 |
| Nong, L | 1 |
| Sang, L | 1 |
| Xu, Y | 1 |
| Liu, X | 1 |
| Li, Y | 1 |
| Huang, Y | 1 |
| Nannan Panday, RS | 1 |
| Schinkel, M | 1 |
| Nutbeam, T | 1 |
| Alam, N | 1 |
| Nanayakkara, PWB | 1 |
| Dubus, M | 1 |
| Ladhani, S | 1 |
| Vasu, V | 1 |
| Dong, V | 1 |
| Nanchal, R | 1 |
| Karvellas, CJ | 1 |
| Kerchberger, VE | 1 |
| Ware, LB | 4 |
| Simon, A | 1 |
| Leffler, A | 1 |
| Patanwala, AE | 1 |
| Aljuhani, O | 1 |
| Bakhsh, H | 1 |
| Erstad, BL | 1 |
| Babayigit, A | 1 |
| Ozaydın, S | 1 |
| Cetinkaya, M | 1 |
| Sander, S | 1 |
| Greenberg, JA | 1 |
| Poston, JT | 1 |
| Amathieu, R | 1 |
| Levesque, E | 1 |
| Merle, JC | 1 |
| Chemit, M | 1 |
| Costentin, C | 1 |
| Compagnon, P | 1 |
| Dhonneur, G | 1 |
| Hartmann, M | 1 |
| de Groot, H | 1 |
| Janz, DR | 3 |
| Bastarache, JA | 2 |
| Rice, TW | 1 |
| Bernard, GR | 1 |
| Warren, MA | 1 |
| Wickersham, N | 2 |
| Sills, G | 2 |
| Oates, JA | 1 |
| Roberts, LJ | 2 |
| Husain, AA | 1 |
| Martin, GS | 1 |
| Hulley, SL | 1 |
| Perring, J | 1 |
| Manning, N | 1 |
| Olpin, S | 1 |
| Yap, S | 1 |
| Chiumello, D | 1 |
| Gotti, M | 1 |
| Vergani, G | 1 |
| Hersch, M | 1 |
| Raveh, D | 1 |
| Izbicki, G | 1 |
| Mrozek, S | 1 |
| Constantin, JM | 1 |
| Futier, E | 1 |
| Zenut, M | 1 |
| Ghardes, G | 1 |
| Cayot-Constantin, S | 1 |
| Bonnard, M | 1 |
| Ait-Bensaid, N | 1 |
| Eschalier, A | 1 |
| Bazin, JE | 1 |
| Myall, K | 1 |
| Sidney, J | 1 |
| Marsh, A | 1 |
| Selladurai, S | 1 |
| Eastwood, GM | 1 |
| Bailey, M | 1 |
| Bellomo, R | 2 |
| Audimoolam, VK | 1 |
| Wendon, J | 1 |
| Bernal, W | 1 |
| Heaton, N | 1 |
| O'Grady, J | 1 |
| Auzinger, G | 1 |
| Saxena, MK | 1 |
| Hammond, NE | 1 |
| Taylor, C | 1 |
| Young, P | 1 |
| Reade, MC | 1 |
| Myburgh, J | 1 |
| Porta, R | 1 |
| Sánchez, L | 1 |
| Nicolás, M | 1 |
| García, C | 1 |
| Martínez, M | 1 |
| Amer, H | 1 |
| Dockery, F | 1 |
| Barrett, N | 1 |
| George, M | 1 |
| Witek, K | 1 |
| Stanton, J | 1 |
| Back, D | 1 |
| Mohr, N | 1 |
| Skrupky, L | 1 |
| Fuller, B | 1 |
| Moy, H | 1 |
| Alunday, R | 1 |
| Wallendorf, M | 1 |
| Micek, S | 1 |
| Fagley, R | 1 |
| Peterson, JF | 1 |
| May, AK | 1 |
| Adams, MW | 1 |
| Chrispin, P | 1 |
| Spice, M | 1 |
| Davies, MW | 1 |
| Kimble, RM | 1 |
| Cartwright, DW | 1 |
| Peter, JV | 1 |
| Rogers, N | 1 |
| Murty, S | 1 |
| Gerace, R | 1 |
| Mackay, R | 1 |
| Peake, SL | 1 |
| Wyke, RJ | 1 |
| Canalese, JC | 1 |
| Gimson, AE | 1 |
| Williams, R | 1 |
| Mazur, LJ | 1 |
| Jones, TM | 1 |
| Kozinetz, CA | 1 |
| Fudin, R | 1 |
| Prego, J | 1 |
| Schwartz, M | 1 |
| Shostak, A | 1 |
| Jaichenko, J | 1 |
| Gotloib, L | 1 |
| Baker, RC | 1 |
| Tiller, T | 1 |
| Bausher, JC | 1 |
| Bellet, PS | 1 |
| Cotton, WH | 1 |
| Finley, AH | 1 |
| Lenane, AM | 1 |
| McHenry, C | 1 |
| Perez, KK | 1 |
| Shapiro, RA | 1 |
| Torrey, SB | 1 |
| Henretig, F | 1 |
| Fleisher, G | 1 |
| Goldstein, RM | 1 |
| Ardire, A | 1 |
| Ludwig, S | 1 |
| Ruddy, R | 1 |
| Wardle, EN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety and Antipyretic Efficacy of Acetaminophen in the Febrile Intensive Care Unit Patient.[NCT02280239] | Phase 4 | 10 participants (Actual) | Interventional | 2015-05-31 | Terminated (stopped due to Only enrolled 10 participants over 9 months which is less then anticipated (75).) | ||
| Effects of Intravenous Acetaminophen on Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: a Randomized Controlled Trial[NCT01869699] | Phase 4 | 41 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Comparison of the Efficacy of Paracetamol and Ibuprofen in the Management of Fever in Sepsis Patients: A Randomized Double-Blind Controlled Study[NCT06061575] | Phase 4 | 84 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Clinically significant hypotension is defined as an acute drop in mean arterial pressure requiring treatment. Treatment is defined as either a 500 cc (or greater) fluid bolus and/or an increase in inotrope support of greater than 5 mcg/min over baseline. (NCT02280239)
Timeframe: 4 hours post acetaminophen administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Control Group | 0 |
| Acetaminophen Group | 0 |
systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressures (MAP) will be monitored for 4 hours post intervention (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mmHg (Mean) | |||||
|---|---|---|---|---|---|---|
| SBP: Pre-Intervention (2 hours) | SBP: Post-Intervention (4 hours) | DBP: Pre-Intervention (2 hours) | DBP: Post-Intervention (4 hours) | MAP: Pre-Intervention (2 hours) | MAP: Post-Intervention (4 hours) | |
| Acetaminophen Group | 122.6 | 119.5 | 66.2 | 65.4 | 84.1 | 82.4 |
| Control Group | 141.6 | 141.5 | 57.4 | 51.0 | 80.8 | 75.5 |
"Total dose of all vasoactive medications will be converted to total Equidose value (with the formula 10 mcg/min norepinephrine ≈ 5 mcg/kg/min dopamine ≈ 10 mcg/min epinephrine ≈ 1 mcg/min phenylephrine ≈ 0.02 u/min vasopressin as per Russell et al. (2008)) before comparing the treatment and control groups~Only 2 of the 6 participants were on low-dose vasoactive medications, (i.e., one was on norepinephrine and the other was on milrinone) therefore the pre-planned conversion calculation was not done." (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mcg (Number) | |||
|---|---|---|---|---|
| Pre-Intervention (2 hours) TOTAL Norepinephrine | Pre-Intervention (2 hours) TOTAL Milrinone | Post-Intervention (4 hours) TOTAL Norepinephrine | Post-Intervention (4 hours) TOTAL Milrinone | |
| Acetaminophen Group | NA | 6000.0 | NA | 7000.0 |
| Control Group | 167.0 | NA | 576.0 | NA |
Total crystalloid and colloid fluid will be converted the the equi-volume dose (with the ratio 1.4:1 (as per Finfer et al.(2004) & Vincent and Weil (2006) before making comparisons between the treatment and control groups. (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mL (Mean) | |||
|---|---|---|---|---|
| Pre-Intervention (2 hours) Total fluid INTAKE | Pre-Intervention (2 hours) Total fluid OUTPUT | Post-Intervention (4 hours) Total Fluid INTAKE | Post-Intervention (4 hours) Total Fluid OUTPUT | |
| Acetaminophen Group | 298 | 370 | 612 | 852 |
| Control Group | 235 | 80 | 734 | 245 |
"Continuous measurements of core body temperature will be recorded for 6 hours. Fever burden (FB) is defined as area between the 6 hour temperature curve and 38.3°C cut-off and it is reported in °C-hour.~PRE-INTERVENTION FB: is reported for a 2 hour period. POST-INTERVENTION FB: post-intervention fever burden is reported for a 6 hour period and average hourly fever burden.~Peak Temperature: is the highest recorded temperature for the study period in °C Minimum Temperature: is the lowest recorded temperature for the study period in °C" (NCT02280239)
Timeframe: 6 hours post intervention
| Intervention | °C*hours (Mean) | |
|---|---|---|
| Pre-Intervention FB (2 hours) | Post-Intervention FB (6 hours) | |
| Acetaminophen Group | 2.16 | 5.65 |
| Control Group | 0.97 | 0.74 |
change over time core temperature after study drug administration (adjusted to baseline core temperature) (NCT01869699)
Timeframe: 2 hours
| Intervention | degrees Celsius (Mean) |
|---|---|
| Normal Saline Placebo | -0.01 |
| Acetaminophen | -0.8 |
2-hour change over time heart rate from time of study drug administration (means adjusted to baseline HR) (NCT01869699)
Timeframe: Baseline to 2 hours
| Intervention | BPM (Mean) |
|---|---|
| Normal Saline Placebo | 2 |
| Acetaminophen | -6 |
2-hour change over time SBP from study drug administration (means adjusted to baseline SBP) (NCT01869699)
Timeframe: Baseline to 2 hours
| Intervention | mm Hg (Mean) |
|---|---|
| Normal Saline Placebo | -0.1 |
| Acetaminophen | -24 |
time-weighted average core body temperature over 4 hours. Core temperature was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the core temperature values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration
| Intervention | degrees Celsius (Mean) |
|---|---|
| Normal Saline Placebo | 38.4 |
| Acetaminophen | 37.9 |
time-weighted average heart rate over 4 hours. Heart rate was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the heart rate values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration
| Intervention | beats per minute (Mean) |
|---|---|
| Normal Saline Placebo | 92 |
| Acetaminophen | 87 |
time weighted average for respiratory rate over 4 hours. Respiratory rate was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the respiratory rate values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration
| Intervention | breaths per minute (Mean) |
|---|---|
| Normal Saline Placebo | 22 |
| Acetaminophen | 21 |
time-weighted average systolic blood pressure over 4 hours. Systolic blood pressure was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the systolic blood pressure values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration
| Intervention | mm Hg (Mean) |
|---|---|
| Normal Saline Placebo | 143 |
| Acetaminophen | 127 |
6 reviews available for acetaminophen and Blood Poisoning
| Article | Year |
|---|---|
Pathophysiology of Acute Liver Failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema | 2020 |
The Role of Circulating Cell-Free Hemoglobin in Sepsis-Associated Acute Kidney Injury.
Topics: Acetaminophen; Acute Kidney Injury; Anemia, Sickle Cell; Animals; Coronary Artery Bypass; Disseminat | 2020 |
[Antipyretics in intensive care patients].
Topics: Acetaminophen; Antipyretics; Critical Care; Critical Illness; Fever; Humans; Sepsis | 2017 |
[Severe toxic acute liver failure: etiology and treatment].
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Anti-Infective Agents; Blood Coagulation Disorde | 2013 |
Paracetamol in fever in critically ill patients-an update.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Critical Illness; Cyclooxygenase | 2017 |
Lack of toxicity after paracetamol overdose in a extremely preterm neonate.
Topics: Abdominal Pain; Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced L | 2012 |
1 trial available for acetaminophen and Blood Poisoning
| Article | Year |
|---|---|
Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cell-Free System; Creatinine; Critical Illness; Doub | 2015 |
31 other studies available for acetaminophen and Blood Poisoning
| Article | Year |
|---|---|
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Pharmacogenetics in critical care: association between CYP3A5 rs776746 A/G genotype and acetaminophen response in sepsis and septic shock.
Topics: Acetaminophen; Adult; Critical Care; Cytochrome P-450 CYP3A; Genotype; Humans; Pharmacogenetics; Sep | 2023 |
Acetaminophen impairs ferroptosis in the hippocampus of septic mice by regulating glutathione peroxidase 4 and ferroptosis suppressor protein 1 pathways.
Topics: Acetaminophen; Animals; Ferroptosis; Hippocampus; Iron; Mice; Phospholipid Hydroperoxide Glutathione | 2023 |
A diagnostic model for sepsis-induced acute lung injury using a consensus machine learning approach and its therapeutic implications.
Topics: Acetaminophen; Acute Lung Injury; Consensus; Humans; Machine Learning; rho Guanine Nucleotide Dissoc | 2023 |
The effects of a single dose of paracetamol in a critical phase of sepsis: a sub-analysis of the PHANTASi trial.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Emergency Medical Services; Female | 2019 |
Prophylactic Paracetamol After Meningococcal B Vaccination Reduces Postvaccination Fever and Septic Screens in Hospitalized Preterm Infants.
Topics: Acetaminophen; Female; Fever; Hospitalization; Humans; Infant; Infant, Newborn; Infant, Premature; M | 2020 |
Effect of Acetaminophen on the Prevention of Acute Kidney Injury in Patients With Sepsis.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Aged; Critical Illness; Female; Humans; Intensive Care Un | 2018 |
Neonatal gastric perforations in very low birth weight infants: a single center experience and review of the literature.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Asphyxia Neonatorum; Chorioamnionitis; Ductus Arteriosus, P | 2018 |
Hemoglobin-unchained and causing harm in sepsis?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Hemoglobins; Hospital Mortality; Humans; Male; Oxid | 2013 |
Cell-free hemoglobin: a new player in sepsis pathophysiology.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Hemoglobins; Hospital Mortality; Humans; Male; Oxid | 2013 |
The authors reply.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Hemoglobins; Hospital Mortality; Humans; Male; Oxid | 2013 |
What is old is new again: acetaminophen as a novel approach to treating sepsis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; F2-Isoprostanes; Female; Humans; Male; Oxidation-Reduction; | 2015 |
Transient 5-oxoprolinuria: unusually high anion gap acidosis in an infant.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Amino Acid Metabolism, Inborn Errors; Analgesics, No | 2015 |
Effect of intravenous propacetamol on blood pressure in febrile critically ill patients.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Blood Pressure; | 2008 |
Effect of intravenous propacetamol on blood pressure in febrile critically ill patients.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Blood Pressure; | 2008 |
Effect of intravenous propacetamol on blood pressure in febrile critically ill patients.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Blood Pressure; | 2008 |
Effect of intravenous propacetamol on blood pressure in febrile critically ill patients.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Blood Pressure; | 2008 |
[Acetaminophene-induced hypotension in intensive care unit: a prospective study].
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Brain Injuries; Endpoint Determinatio | 2009 |
Mind the gap! An unusual metabolic acidosis.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Anti-Bacterial Agents; Antioxidants; Female; Floxacillin; H | 2011 |
Paracetamol therapy for septic critically ill patients: a retrospective observational study.
Topics: Acetaminophen; Antipyretics; Critical Illness; Female; Humans; Intensive Care Units; Male; Middle Ag | 2011 |
Iron and acetaminophen a fatal combination?
Topics: Accidents; Acetaminophen; Adolescent; Adult; Biopsy; Brain; Diclofenac; Drug Overdose; Female; Human | 2011 |
A survey of fever management for febrile intensive care patients without neurological injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Attitude of Health Personnel; Critical Illness; Fever; Heal | 2011 |
Refractory metabolic acidosis in patients with sepsis following hemiarthroplasty for femoral neck fracture: a causative role for paracetamol and flucloxacillin?
Topics: Acetaminophen; Acidosis; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Female; | 2011 |
Early antipyretic exposure does not increase mortality in patients with gram-negative severe sepsis: a retrospective cohort study.
Topics: Acetaminophen; Adult; Aged; Antipyretics; Female; Fever; Gram-Negative Bacterial Infections; Hospita | 2012 |
Association between cell-free hemoglobin, acetaminophen, and mortality in patients with sepsis: an observational study.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Cell-Free System; Confidence Intervals; F2-Isoprostan | 2013 |
An unusual paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Critical Care; Drug Overdose; Humans; Hypernatremia; Male; | 2004 |
Gastroschisis: ward reduction compared with traditional reduction under general anesthesia.
Topics: Abdominal Wall; Acetaminophen; Analgesics, Non-Narcotic; Anesthesia, General; Antibiotic Prophylaxis | 2005 |
An unusual cause of severe metabolic acidosis.
Topics: Acetaminophen; Acidosis; Acute Kidney Injury; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Floxa | 2006 |
Bacteraemia in patients with fulminant hepatic failure.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; H | 1982 |
Temperature response to acetaminophen and risk of occult bacteremia: a case-control study.
Topics: Acetaminophen; Child; Child, Preschool; Female; Fever of Unknown Origin; Humans; Infant; Male; Medic | 1989 |
Sequential hemofiltration in MOF associated with paracetamol intoxication and gram-negative sepsis.
Topics: Acetaminophen; Child; Hemofiltration; Humans; Klebsiella Infections; Male; Multiple Organ Failure; S | 1989 |
Severity of disease correlated with fever reduction in febrile infants.
Topics: Acetaminophen; Body Temperature; Fever; Haemophilus Infections; Haemophilus influenzae; Humans; Infa | 1989 |
Temperature response to antipyretic therapy in children: relationship to occult bacteremia.
Topics: Acetaminophen; Aspirin; Body Temperature; Child, Preschool; Fever; Haemophilus Infections; Haemophil | 1985 |
Fibrinogen in liver disease.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cholangitis; Cholestasis; Contusions; Endotox | 1974 |