acetaminophen has been researched along with Blood Coagulation Disorders in 22 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Blood Coagulation Disorders: Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with acetaminophen (APAP)-induced acute liver failure (ALF) display both hyper- and hypocoagulable changes not necessarily recapitulated by standard hepatotoxic doses of APAP used in mice (eg, 300 mg/kg)." | 8.31 | Robust coagulation activation and coagulopathy in mice with experimental acetaminophen-induced liver failure. ( Bouck, EG; Groeneveld, DJ; Lisman, T; Luyendyk, JP; Poole, LG; Schulte, A; Watson, VE; Wei, Z; Williams, KJ; Wolberg, AS, 2023) |
| "Acetaminophen toxicity is common and is characterized by hepatic failure." | 7.88 | Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( Dib, C; Levine, M; Peak, DA; Pizon, AF; Stellpflug, SJ; Thomas, SH; Villano, J; Wiegand, T, 2018) |
| "Patients with acetaminophen (APAP)-induced acute liver failure (ALF) display both hyper- and hypocoagulable changes not necessarily recapitulated by standard hepatotoxic doses of APAP used in mice (eg, 300 mg/kg)." | 4.31 | Robust coagulation activation and coagulopathy in mice with experimental acetaminophen-induced liver failure. ( Bouck, EG; Groeneveld, DJ; Lisman, T; Luyendyk, JP; Poole, LG; Schulte, A; Watson, VE; Wei, Z; Williams, KJ; Wolberg, AS, 2023) |
| "Acetaminophen toxicity is common and is characterized by hepatic failure." | 3.88 | Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( Dib, C; Levine, M; Peak, DA; Pizon, AF; Stellpflug, SJ; Thomas, SH; Villano, J; Wiegand, T, 2018) |
| "This is the third case reported of maternal acetaminophen overdose during pregnancy." | 3.68 | Can acetaminophen excess result in maternal and fetal toxicity? ( Kurzel, RB, 1990) |
| "Acute liver failure is a rare but life-threatening disease that can lead to progressive encephalopathy, intracranial hypertension, and multiorgan failure." | 2.58 | Modern Management of Acute Liver Failure. ( Khan, R; Koppe, S, 2018) |
| " The possible causes for the injury from ostensibly nontoxic drug levels appear to be either the induction by chronic alcohol intake of the cytochrome P-450 system responsible for converting acetaminophen to a toxic metabolite, or the effect of alcoholism and the associated malnutrition in reducing the glutathione concentration, responsible normally for preventing hepatotoxicity by conjugation with the toxic metabolite." | 2.37 | Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure. ( Adler, E; Benjamin, SB; Cuccherini, BA; Seeff, LB; Zimmerman, HJ, 1986) |
| "BACKGROUND Fulminant hepatic failure (FHF) is commonly associated with elevated prothrombin time (PT) and international normalized ratio (INR)." | 1.91 | A 36-Year-Old Woman with Acute Liver Failure Following Acetaminophen Overdose, Raised INR of 8.7, and Normal Blood Viscosity Measured by Rotational Thromboelastometry (ROTEM). ( Elia, E; Lai, M; Nguyen, T; Yoon, U, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (40.91) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Yoon, U | 1 |
| Lai, M | 1 |
| Nguyen, T | 1 |
| Elia, E | 1 |
| Groeneveld, DJ | 1 |
| Poole, LG | 1 |
| Bouck, EG | 1 |
| Schulte, A | 1 |
| Wei, Z | 1 |
| Williams, KJ | 1 |
| Watson, VE | 1 |
| Lisman, T | 2 |
| Wolberg, AS | 1 |
| Luyendyk, JP | 1 |
| Boster, JM | 1 |
| Adams, MA | 1 |
| Moore, HB | 1 |
| Stravitz, RT | 1 |
| Fontana, RJ | 1 |
| Meinzer, C | 1 |
| Durkalski-Mauldin, V | 1 |
| Hanje, AJ | 1 |
| Olson, J | 1 |
| Koch, D | 1 |
| Hamid, B | 1 |
| Schilsky, ML | 1 |
| McGuire, B | 1 |
| Ganger, D | 1 |
| Liou, I | 1 |
| Karvellas, CJ | 1 |
| Rule, JA | 1 |
| Clasen, K | 1 |
| Reuben, A | 1 |
| Cripps, M | 1 |
| Lee, WM | 1 |
| Levine, M | 1 |
| Stellpflug, SJ | 1 |
| Pizon, AF | 1 |
| Peak, DA | 1 |
| Villano, J | 1 |
| Wiegand, T | 1 |
| Dib, C | 1 |
| Thomas, SH | 1 |
| Khan, R | 1 |
| Koppe, S | 1 |
| Amathieu, R | 1 |
| Levesque, E | 1 |
| Merle, JC | 1 |
| Chemit, M | 1 |
| Costentin, C | 1 |
| Compagnon, P | 1 |
| Dhonneur, G | 1 |
| Marks, DJB | 1 |
| Dargan, PI | 1 |
| Archer, JRH | 1 |
| Davies, CL | 1 |
| Dines, AM | 1 |
| Wood, DM | 1 |
| Greene, SL | 1 |
| LOZINSKI, E | 1 |
| Kerr, R | 1 |
| Evensen, SA | 1 |
| Førde, R | 1 |
| Opedal, I | 1 |
| Stormorken, H | 1 |
| Day, A | 1 |
| Abbott, GD | 1 |
| Dunn, RJ | 1 |
| Waltman, R | 1 |
| Tricomi, V | 1 |
| Tavakoli, FM | 1 |
| Kurzel, RB | 1 |
| Seeff, LB | 1 |
| Cuccherini, BA | 1 |
| Zimmerman, HJ | 1 |
| Adler, E | 1 |
| Benjamin, SB | 1 |
| Matthew, H | 2 |
| Clark, R | 2 |
| Rake, MO | 1 |
| Flute, PT | 1 |
| Williams, R | 2 |
| Rueff, B | 1 |
| Benhamou, JP | 1 |
| Gazzard, BG | 1 |
| Borirakchanyavat, V | 1 |
5 reviews available for acetaminophen and Blood Coagulation Disorders
| Article | Year |
|---|---|
Modern Management of Acute Liver Failure.
Topics: Acetaminophen; Acetylcysteine; Biomarkers; Blood Coagulation Disorders; Brain Diseases; Free Radical | 2018 |
[Severe toxic acute liver failure: etiology and treatment].
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Anti-Infective Agents; Blood Coagulation Disorde | 2013 |
New insights into haemostasis in liver failure.
Topics: Acetaminophen; Acute Disease; Antithrombins; Blood Coagulation Disorders; Blood Coagulation Factors; | 2003 |
Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure.
Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Blood Coagulati | 1986 |
Acute hepatic necrosis and fulminant hepatic failure.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Animals; Blood Coagulation Disorders; Brain Dise | 1973 |
1 trial available for acetaminophen and Blood Coagulation Disorders
| Article | Year |
|---|---|
A controlled trial of heparin therapy in the coagulation defect of paracetamol-induced hepatic necrosis.
Topics: Acetaminophen; Adolescent; Adult; Blood Coagulation Disorders; Blood Transfusion; Chemical and Drug | 1974 |
16 other studies available for acetaminophen and Blood Coagulation Disorders
| Article | Year |
|---|---|
A 36-Year-Old Woman with Acute Liver Failure Following Acetaminophen Overdose, Raised INR of 8.7, and Normal Blood Viscosity Measured by Rotational Thromboelastometry (ROTEM).
Topics: Acetaminophen; Adult; Blood Coagulation Disorders; Blood Viscosity; Female; Humans; International No | 2023 |
Robust coagulation activation and coagulopathy in mice with experimental acetaminophen-induced liver failure.
Topics: Acetaminophen; Animals; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Fibrin; | 2023 |
Commentary on "Robust coagulation activation and coagulopathy in mice with experimental acetaminophen-induced liver failure".
Topics: Acetaminophen; Animals; Blood Coagulation; Blood Coagulation Disorders; Liver Failure; Mice | 2023 |
Coagulopathy, Bleeding Events, and Outcome According to Rotational Thromboelastometry in Patients With Acute Liver Injury/Failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Blood Coagulation Disorders; Chemical and Drug Induced Liver | 2021 |
Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients.
Topics: Acetaminophen; Acidosis, Lactic; Adult; Blood Coagulation Disorders; Chemical and Drug Induced Liver | 2018 |
Outcomes from massive paracetamol overdose: a retrospective observational study.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Asp | 2017 |
THE COMPARATIVE PHARMACOLOGY.
Topics: Acetaminophen; Acetanilides; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Blood Coag | 1963 |
I have osteoarthritis in my knees. I also have a blood-clotting disorder and have been put on Coumadin, which means I can't take NSAIDs. I take a daily dose of Tylenol, but it doesn't have much effect. What do you suggest?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Bl | 2007 |
Acute iron intoxication with abruptly reduced levels of vitamin K-dependent coagulation factors.
Topics: Acetaminophen; Adolescent; Alcohol Drinking; Blood Coagulation Disorders; Female; Humans; Iron; Iron | 1982 |
Chronic paracetamol poisoning in children: a warning to health professionals.
Topics: Acetaminophen; Blood Coagulation Disorders; Chronic Disease; Diarrhea; Drug Overdose; Health Occupat | 1994 |
Massive sulfasalazine and paracetamol ingestion causing acidosis, hyperglycemia, coagulopathy, and methemoglobinemia.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Acute Disease; Adult; Anti-Inflammatory Agents; Blo | 1998 |
Effect of aspirin on bleeding time during elective abortion.
Topics: Abortion, Induced; Acetaminophen; Adolescent; Adult; Aspirin; Blood Coagulation; Blood Coagulation D | 1976 |
Can acetaminophen excess result in maternal and fetal toxicity?
Topics: Acetaminophen; Adult; Blood Coagulation Disorders; Cerebral Hemorrhage; Chemical and Drug Induced Li | 1990 |
Removal of paracetamol by hemoperfusion.
Topics: Acetaminophen; Blood Coagulation Disorders; Blood Platelets; Chemical and Drug Induced Liver Injury; | 1973 |
Coagulation abnormalities in acute liver failure; pathogenetic and therapeutic implications.
Topics: Acetaminophen; Acute Disease; Bilirubin; Biopsy; Blood Coagulation Disorders; Blood Coagulation Test | 1973 |
Acute acetaminophen poisoning.
Topics: Acetaminophen; Bilirubin; Blood Coagulation Disorders; Cardiomyopathies; Diuresis; Humans; Hypoglyce | 1973 |