Page last updated: 2024-10-22

acetaminophen and Bladder Cancer

acetaminophen has been researched along with Bladder Cancer in 22 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

ExcerptRelevanceReference
"The case of a patient receiving long-term anticoagulation with warfarin who had supratherapeutic International Normalized Ratios (INRs) after receiving concomitant acetaminophen and moxifloxacin as prophylaxis with bacille Calmette-Guérin (BCG) therapy for bladder cancer is reported."7.77Moxifloxacin-acetaminophen-warfarin interaction during bacille Calmette-Guerin treatment for bladder cancer. ( Berube, C; Lee, R; Wen, A, 2011)
"We conducted a nested, matched case-control study in the General Practice Research Database (GPRD) to assess whether acetaminophen use is associated with renal or bladder cancer."7.71Acetaminophen and the risk of renal and bladder cancer in the general practice research database. ( Jick, H; Kaye, JA; Myers, MW, 2001)
"Acetaminophen is a metabolite of phenacetin, a drug that has been implicated as a causal agent in the development of renal and bladder cancer."7.69Acetaminophen and renal and bladder cancer. ( Derby, LE; Jick, H, 1996)
"We investigated the use of analgesics containing phenacetin or acetaminophen in 173 young women with urinary bladder cancer and 173 matched controls."7.67Heavy phenacetin use and bladder cancer in women aged 20 to 49 years. ( Matanoski, GM; Piper, JM; Tonascia, J, 1985)
"Phenacetin was withdrawn from the Danish market on 1."6.38[Phenacetin, paracetamol and bladder cancer]. ( Jensen, OM; Nørgaard, N, 1990)
"The results of our meta-analysis suggest that there is no association between use of acetaminophen, aspirin or non-aspirin NSAIDs and bladder cancer risk."4.89Use of nonsteroidal anti-inflammatory drugs and bladder cancer risk: a meta-analysis of epidemiologic studies. ( Jiang, D; Li, X; Zhang, H, 2013)
"The case of a patient receiving long-term anticoagulation with warfarin who had supratherapeutic International Normalized Ratios (INRs) after receiving concomitant acetaminophen and moxifloxacin as prophylaxis with bacille Calmette-Guérin (BCG) therapy for bladder cancer is reported."3.77Moxifloxacin-acetaminophen-warfarin interaction during bacille Calmette-Guerin treatment for bladder cancer. ( Berube, C; Lee, R; Wen, A, 2011)
" However, acetaminophen, a major metabolite of phenacetin, may be positively associated with bladder cancer risk."3.74Nonsteroidal antiinflammatory drug use and risk of bladder cancer in the health professionals follow-up study. ( De Vivo, I; Genkinger, JM; Giovannucci, E; Michaud, DS; Stampfer, MJ, 2007)
"We conducted a nested, matched case-control study in the General Practice Research Database (GPRD) to assess whether acetaminophen use is associated with renal or bladder cancer."3.71Acetaminophen and the risk of renal and bladder cancer in the general practice research database. ( Jick, H; Kaye, JA; Myers, MW, 2001)
"Acetaminophen is a metabolite of phenacetin, a drug that has been implicated as a causal agent in the development of renal and bladder cancer."3.69Acetaminophen and renal and bladder cancer. ( Derby, LE; Jick, H, 1996)
"We investigated the use of analgesics containing phenacetin or acetaminophen in 173 young women with urinary bladder cancer and 173 matched controls."3.67Heavy phenacetin use and bladder cancer in women aged 20 to 49 years. ( Matanoski, GM; Piper, JM; Tonascia, J, 1985)
" Studies of the relationship between genotoxicity and toxic effects in the rat (induction of micronuclei in rat bone marrow including dose-response relationship, biotransformation of paracetamol at different dosages, concomitant toxicity and biochemical markers) have recently been completed."2.39Series: current issues in mutagenesis and carcinogenesis, No. 65. The genotoxicity and carcinogenicity of paracetamol: a regulatory (re)view. ( Bergman, K; Müller, L; Teigen, SW, 1996)
"Phenacetin was withdrawn from the Danish market on 1."2.38[Phenacetin, paracetamol and bladder cancer]. ( Jensen, OM; Nørgaard, N, 1990)
"Acetaminophen pretreatment decreases the sulfate availability, but results in many side effects that complicate the analysis of the results."2.36Sulfation and glucuronidation as competing pathways in the metabolism of hydroxamic acids: the role of N,O-sulfonation in chemical carcinogenesis of aromatic amines. ( Meerman, JH; Mulder, GJ, 1983)
"Bladder cancer is one of the most common urogenital tumors."1.51Can intravesical application of paracetamol benefit the chemotherapy treatment of bladder cancer? ( Buğday, MS; Öksüz, E, 2019)
"A case of painful priapism is reported in a patient who had previously suffered a radical cystectomy for bladder carcinoma pT3-GIII, followed by local recurrence in the pelvis."1.29Priapism of the clitoris. ( Arteaga, PR; Galbis, F; Monllor, J; Taño, F, 1996)
"0% dosage level, 20% of rats of both sexes developed neoplastic nodules of the liver, a statistically significant incidence."1.27Induction by paracetamol of bladder and liver tumours in the rat. Effects on hepatocyte fine structure. ( Flaks, A; Flaks, B; Shaw, AP, 1985)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199012 (54.55)18.7374
1990's5 (22.73)18.2507
2000's2 (9.09)29.6817
2010's3 (13.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Öksüz, E1
Buğday, MS1
Zhang, H1
Jiang, D1
Li, X1
Lee, R1
Wen, A1
Berube, C1
Genkinger, JM1
De Vivo, I1
Stampfer, MJ1
Giovannucci, E1
Michaud, DS1
Tsuda, H1
Fukushima, S2
Imaida, K1
Sakata, T1
Ito, N1
Mulder, GJ1
Meerman, JH1
Bach, PH2
Bridges, JW2
Andersson, B1
Nordenskjöld, M1
Rahimtula, A1
Moldéus, P1
Bergman, K1
Müller, L1
Teigen, SW1
Derby, LE1
Jick, H2
Monllor, J1
Taño, F1
Arteaga, PR1
Galbis, F1
Kaye, JA1
Myers, MW1
Nørgaard, N1
Jensen, OM1
Dolara, P1
Lodovici, M1
Salvadori, M1
Saltutti, C1
Delle Rose, A1
Selli, C1
Kriebel, D1
McCredie, M1
Stewart, JH1
Kurata, Y1
Asamoto, M1
Hagiwara, A1
Masui, T1
Piper, JM1
Tonascia, J1
Matanoski, GM1
Flaks, B1
Flaks, A1
Shaw, AP1
Bengtsson, V1
Weisburger, JH1
Weisburger, EK1
Madison, RM1
Wenk, ML1
Klein, DS1

Reviews

6 reviews available for acetaminophen and Bladder Cancer

ArticleYear
Use of nonsteroidal anti-inflammatory drugs and bladder cancer risk: a meta-analysis of epidemiologic studies.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Risk; Urinary Bladder Neopl

2013
Sulfation and glucuronidation as competing pathways in the metabolism of hydroxamic acids: the role of N,O-sulfonation in chemical carcinogenesis of aromatic amines.
    Environmental health perspectives, 1983, Volume: 49

    Topics: Acetaminophen; Amines; Animals; Binding Sites; Biological Availability; Carcinogens; Diet; Glucurona

1983
Series: current issues in mutagenesis and carcinogenesis, No. 65. The genotoxicity and carcinogenicity of paracetamol: a regulatory (re)view.
    Mutation research, 1996, Feb-01, Volume: 349, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bacteria; Biotransformation; Carcinogens; Cell Lin

1996
Paracetamol.
    IARC monographs on the evaluation of carcinogenic risks to humans, 1999, Volume: 73

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carcinogens; Chemical and Drug Induced Liver Injur

1999
[Phenacetin, paracetamol and bladder cancer].
    Ugeskrift for laeger, 1990, Dec-03, Volume: 152, Issue:49

    Topics: Acetaminophen; Humans; Phenacetin; Urinary Bladder Neoplasms

1990
Chemically induced renal papillary necrosis and upper urothelial carcinoma. Part 1.
    Critical reviews in toxicology, 1985, Volume: 15, Issue:3

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Carbohy

1985

Other Studies

16 other studies available for acetaminophen and Bladder Cancer

ArticleYear
Can intravesical application of paracetamol benefit the chemotherapy treatment of bladder cancer?
    Medical hypotheses, 2019, Volume: 131

    Topics: Acetaminophen; Administration, Intravesical; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic

2019
Moxifloxacin-acetaminophen-warfarin interaction during bacille Calmette-Guerin treatment for bladder cancer.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2011, May-01, Volume: 68, Issue:9

    Topics: Acetaminophen; Adjuvants, Immunologic; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Infective A

2011
Nonsteroidal antiinflammatory drug use and risk of bladder cancer in the health professionals follow-up study.
    International journal of cancer, 2007, May-15, Volume: 120, Issue:10

    Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Follow

2007
Modification of carcinogenesis by antioxidants and other compounds.
    Acta pharmacologica et toxicologica, 1984, Volume: 55 Suppl 2

    Topics: Acetaminophen; Animals; Antioxidants; Body Weight; Butylated Hydroxyanisole; Carcinogens; Diethylnit

1984
The role of metabolic activation of analgesics and non-steroidal anti-inflammatory drugs in the development of renal papillary necrosis and upper urothelial carcinoma.
    Prostaglandins, leukotrienes, and medicine, 1984, Volume: 15, Issue:2

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; B

1984
Prostaglandin synthetase-catalyzed activation of phenacetin metabolites to genotoxic products.
    Molecular pharmacology, 1982, Volume: 22, Issue:2

    Topics: Acetaminophen; Aminophenols; Animals; Biotransformation; DNA; Glutathione; Humans; Phenacetin; Prost

1982
Acetaminophen and renal and bladder cancer.
    Epidemiology (Cambridge, Mass.), 1996, Volume: 7, Issue:4

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Case-Control Studies; Drug Prescriptions; Fema

1996
Priapism of the clitoris.
    European urology, 1996, Volume: 30, Issue:4

    Topics: Acetaminophen; Aged; Analgesics; Clitoris; Codeine; Diazepam; Fatal Outcome; Female; Humans; Male; M

1996
Acetaminophen and the risk of renal and bladder cancer in the general practice research database.
    Epidemiology (Cambridge, Mass.), 2001, Volume: 12, Issue:6

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Case-Control Studies; Databases, Factual; Family Prac

2001
Variations of cortisol hydroxylation and paracetamol metabolism in patients with bladder carcinoma.
    British journal of urology, 1988, Volume: 62, Issue:5

    Topics: Acetaminophen; Aged; Biotransformation; Carcinoma, Transitional Cell; Humans; Hydrocortisone; Hydrox

1988
Does paracetamol cause urothelial cancer or renal papillary necrosis?
    Nephron, 1988, Volume: 49, Issue:4

    Topics: Acetaminophen; Carcinoma, Transitional Cell; Female; Humans; Kidney Neoplasms; Kidney Papillary Necr

1988
Promoting effects of various agents in rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine.
    Cancer letters, 1986, Volume: 32, Issue:2

    Topics: Acetaminophen; Allopurinol; Aminocaproates; Animals; Biphenyl Compounds; Butylhydroxybutylnitrosamin

1986
Heavy phenacetin use and bladder cancer in women aged 20 to 49 years.
    The New England journal of medicine, 1985, Aug-01, Volume: 313, Issue:5

    Topics: Acetaminophen; Adult; Drug Combinations; Female; Humans; Middle Aged; New York; Phenacetin; Smoking;

1985
Induction by paracetamol of bladder and liver tumours in the rat. Effects on hepatocyte fine structure.
    Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology, 1985, Volume: 93, Issue:6

    Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Female; Liver; Live

1985
Phenacetin.
    Lancet (London, England), 1969, Feb-01, Volume: 1, Issue:7588

    Topics: Acetaminophen; Antipyrine; Denmark; Humans; Kidney Diseases; Kidney Neoplasms; Kidney Papillary Necr

1969
Effect of acetanilide and p-hydroxyacetanilide on the carcinogenicity of N-2-fluorenylacetamide and N-hydroxy-N-2-fluorenylacetamide in mice, hamsters, and female rats.
    Journal of the National Cancer Institute, 1973, Volume: 51, Issue:1

    Topics: Acetamides; Acetaminophen; Acetanilides; Animals; Carcinogens; Cricetinae; Diet; Female; Fluorenes;

1973