acetaminophen has been researched along with Birth Weight in 20 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Birth Weight: The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Databases were searched to identify studies reporting the effects of acetaminophen use during pregnancy on preterm birth, low birth weight, and small for gestational age." | 9.22 | Effect of Acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis. ( Barreto, ML; Castro, CT; Dal-Pizzol, TS; Gama, RS; Oliveira, MG; Pereira, M; Santos, DB, 2022) |
| "Salicylates have been the most widely studied of the nonnarcotic analgesics in pregnancy, and in the last 20 years evidence has accumulated indicating that their ingestion in pregnancy may have adverse effects on the mother and her child." | 8.76 | Maternal and fetal effects of acetaminophen and salicylates in pregnancy. ( Collins, E, 1981) |
| " Poisson regression with robust error variance was used to estimate the relationship between acetaminophen use before and during pregnancy and low birthweight, preterm birth, and small for gestational age." | 7.96 | Association between maternal acetaminophen use and adverse birth outcomes in a pregnancy and birth cohort. ( Arneja, J; Bocking, A; Brooks, JD; Hewko, SL; Hung, RJ; Knight, JA; Lye, SJ; Seeto, RA, 2020) |
| "Databases were searched to identify studies reporting the effects of acetaminophen use during pregnancy on preterm birth, low birth weight, and small for gestational age." | 5.22 | Effect of Acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis. ( Barreto, ML; Castro, CT; Dal-Pizzol, TS; Gama, RS; Oliveira, MG; Pereira, M; Santos, DB, 2022) |
| "Salicylates have been the most widely studied of the nonnarcotic analgesics in pregnancy, and in the last 20 years evidence has accumulated indicating that their ingestion in pregnancy may have adverse effects on the mother and her child." | 4.76 | Maternal and fetal effects of acetaminophen and salicylates in pregnancy. ( Collins, E, 1981) |
| " Poisson regression with robust error variance was used to estimate the relationship between acetaminophen use before and during pregnancy and low birthweight, preterm birth, and small for gestational age." | 3.96 | Association between maternal acetaminophen use and adverse birth outcomes in a pregnancy and birth cohort. ( Arneja, J; Bocking, A; Brooks, JD; Hewko, SL; Hung, RJ; Knight, JA; Lye, SJ; Seeto, RA, 2020) |
| " Preterm (< 37 weeks) and term (37-41 weeks) infants received a single dose of propacetamol in the first 24 hours of life when they had minor, painful procedures or as additional treatment in infants receiving opioids." | 3.72 | Pharmacokinetics of single dose intravenous propacetamol in neonates: effect of gestational age. ( Allegaert, K; Debeer, A; Devlieger, H; Pluim, MA; Tibboel, D; Van der Marel, CD; Van Lingen, RA; Vanhole, C, 2004) |
| " The teratogenic potential of a drug is related to dosage and time of administration." | 2.36 | Analgesics during pregnancy. ( Niederhoff, H; Zahradnik, HP, 1983) |
| " As a result, dosing based on bodyweight alone will not lead to consistent paracetamol concentrations among preterm neonates." | 1.91 | Maturation of Paracetamol Elimination Routes in Preterm Neonates Born Below 32 Weeks of Gestation. ( Flint, RB; Knibbe, CAJ; Krekels, EHJ; Roofthooft, DWE; Simons, SHP; Tibboel, D; Völler, S; Wu, Y, 2023) |
| "Acetaminophen has been increasingly used in treating patent ductus arteriosus (PDA) in preterm neonates." | 1.62 | Intravenous acetaminophen (at 15 mg/kg/dose every 6 hours) in critically ill preterm neonates with patent ductus arteriosus: A prospective study. ( Al Ansari, E; Al Jufairi, M; Al Madhoob, A; Al Marzooq, R; Hasan, SJR; Hubail, Z; Sridharan, K, 2021) |
| "Haemodynamically significant patent ductus arteriosus is a significant cause of morbidity and mortality in pre-term infants." | 1.42 | Intravenous paracetamol with a lower dose is also effective for the treatment of patent ductus arteriosus in pre-term infants. ( Caner, İ; Ceviz, N; Demirelli, Y; Kara, M; Olgun, H; Şahin, İO; Tekgündüz, KŞ; Yolcu, C, 2015) |
| "Ibuprofen treatment was given to 15 paracetamol-treated and to 26 control infants (p = 0." | 1.40 | Early paracetamol treatment associated with lowered risk of persistent ductus arteriosus in very preterm infants. ( Aikio, O; Hallman, M; Härkin, P; Saarela, T, 2014) |
| "A population pharmacokinetic analysis was performed based on 372 PG plasma concentrations from 62 (pre)term neonates (birth weight (bBW) 630-3980 g, postnatal age (PNA) 1-30 days) using NONMEM 6." | 1.39 | Developmental pharmacokinetics of propylene glycol in preterm and term neonates. ( Allegaert, K; Danhof, M; De Cock, RF; de Hoon, J; Knibbe, CA; Kulo, A; Verbesselt, R, 2013) |
| " The mean dosage of paracetamol was 35 mg/kg per day (95% confidence interval: 32-39); the mean dosage of morphine was 0." | 1.38 | Discomfort and pain in newborns with myelomeningocele: a prospective evaluation. ( Dammers, R; de Jong, TH; Kompanje, EJ; Ottenhoff, MJ; Tibboel, D, 2012) |
| "Acetaminophen (APAP) was evaluated for reproductive toxicity in Swiss CD-1 mice using a continuous breeding protocol." | 1.28 | Reproductive toxicity evaluation of acetaminophen in Swiss CD-1 mice using a continuous breeding protocol. ( Lamb, JC; Lawton, AD; Reel, JR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 7 (35.00) | 24.3611 |
| 2020's | 7 (35.00) | 2.80 |
| Authors | Studies |
|---|---|
| Castro, CT | 1 |
| Gama, RS | 1 |
| Pereira, M | 1 |
| Oliveira, MG | 1 |
| Dal-Pizzol, TS | 1 |
| Barreto, ML | 1 |
| Santos, DB | 1 |
| Zafeiri, A | 1 |
| Raja, EA | 1 |
| Mitchell, RT | 1 |
| Hay, DC | 1 |
| Bhattacharya, S | 1 |
| Fowler, PA | 1 |
| Zhong, B | 1 |
| Tan, K | 1 |
| Razak, A | 1 |
| Sackett, V | 1 |
| Machipisa, C | 1 |
| Zhou, L | 1 |
| Samiee-Zafarghandy, S | 1 |
| Sehgal, A | 1 |
| Hunt, RW | 1 |
| Pharande, P | 1 |
| Malhotra, A | 1 |
| Wu, Y | 1 |
| Völler, S | 1 |
| Krekels, EHJ | 1 |
| Roofthooft, DWE | 1 |
| Simons, SHP | 1 |
| Tibboel, D | 3 |
| Flint, RB | 1 |
| Knibbe, CAJ | 1 |
| Arneja, J | 1 |
| Hung, RJ | 1 |
| Seeto, RA | 1 |
| Knight, JA | 1 |
| Hewko, SL | 1 |
| Bocking, A | 1 |
| Lye, SJ | 1 |
| Brooks, JD | 1 |
| Juujärvi, S | 1 |
| Saarela, T | 2 |
| Pokka, T | 1 |
| Hallman, M | 2 |
| Aikio, O | 2 |
| Sridharan, K | 1 |
| Al Jufairi, M | 1 |
| Al Ansari, E | 1 |
| Al Marzooq, R | 1 |
| Hubail, Z | 1 |
| Hasan, SJR | 1 |
| Al Madhoob, A | 1 |
| Novitskaya, ES | 1 |
| Kostakis, V | 1 |
| Broster, SC | 1 |
| Allen, LE | 1 |
| Härkin, P | 1 |
| Terrin, G | 1 |
| Conte, F | 1 |
| Scipione, A | 1 |
| Bacchio, E | 1 |
| Conti, MG | 1 |
| Ferro, R | 1 |
| Ventriglia, F | 1 |
| De Curtis, M | 1 |
| Tekgündüz, KŞ | 1 |
| Ceviz, N | 1 |
| Caner, İ | 1 |
| Olgun, H | 1 |
| Demirelli, Y | 1 |
| Yolcu, C | 1 |
| Şahin, İO | 1 |
| Kara, M | 1 |
| Hopchet, L | 1 |
| Kulo, A | 2 |
| Rayyan, M | 1 |
| Verbesselt, R | 2 |
| Vanhole, C | 2 |
| de Hoon, JN | 1 |
| Allegaert, K | 3 |
| Ottenhoff, MJ | 1 |
| Dammers, R | 1 |
| Kompanje, EJ | 1 |
| de Jong, TH | 1 |
| De Cock, RF | 1 |
| Knibbe, CA | 1 |
| de Hoon, J | 1 |
| Danhof, M | 1 |
| Van der Marel, CD | 1 |
| Debeer, A | 1 |
| Pluim, MA | 1 |
| Van Lingen, RA | 1 |
| Devlieger, H | 1 |
| Niederhoff, H | 1 |
| Zahradnik, HP | 1 |
| Collins, E | 1 |
| Burdan, F | 1 |
| Reel, JR | 1 |
| Lawton, AD | 1 |
| Lamb, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Extremely Low Gestational Age Infants' Paracetamol Study: a Randomized Trial[NCT03641209] | Phase 1/Phase 2 | 40 participants (Actual) | Interventional | 2018-09-03 | Active, not recruiting | ||
| Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus Arteriosus of Preterm Infants - Randomised, Placebo-controlled Multicentre Trial[NCT03648437] | Phase 1 | 60 participants (Anticipated) | Interventional | 2018-09-03 | Recruiting | ||
| Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus in Premature Infants: A Pilot Study[NCT03103022] | Phase 1 | 20 participants (Actual) | Interventional | 2017-06-12 | Completed | ||
| The Copenhagen Analgesic Study[NCT04369222] | 600 participants (Anticipated) | Observational | 2020-03-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for acetaminophen and Birth Weight
| Article | Year |
|---|---|
Effect of Acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Birth Weight; Female; Fetal Development; Humans; Infant, Ne | 2022 |
Analgesics during pregnancy.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Birth Weight; Female; Fetal Death; | 1983 |
Maternal and fetal effects of acetaminophen and salicylates in pregnancy.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Birth Weight; Chemical and Drug Induced Liver I | 1981 |
[Paracetamol prenatal toxicity].
Topics: Abnormalities, Drug-Induced; Acetaminophen; Analgesics, Non-Narcotic; Animals; Birth Weight; Body He | 1999 |
16 other studies available for acetaminophen and Birth Weight
| Article | Year |
|---|---|
Maternal over-the-counter analgesics use during pregnancy and adverse perinatal outcomes: cohort study of 151 141 singleton pregnancies.
Topics: Acetaminophen; Analgesics; Birth Weight; Cohort Studies; Female; Humans; Hypospadias; Infant, Newbor | 2022 |
Early neurodevelopmental outcomes of extreme preterm infants exposed to paracetamol: a retrospective cohort study.
Topics: Acetaminophen; Birth Weight; Ductus Arteriosus, Patent; Female; Humans; Ibuprofen; Infant; Infant, N | 2023 |
Maturation of Paracetamol Elimination Routes in Preterm Neonates Born Below 32 Weeks of Gestation.
Topics: Acetaminophen; Adult; Birth Weight; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premat | 2023 |
Association between maternal acetaminophen use and adverse birth outcomes in a pregnancy and birth cohort.
Topics: Acetaminophen; Adult; Birth Weight; Cohort Studies; Female; Humans; Maternal Exposure; Ontario; Pois | 2020 |
Intravenous paracetamol for neonates: long-term diseases not escalated during 5 years of follow-up.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Apgar Score; Asthma; Birth Wei | 2021 |
Intravenous acetaminophen (at 15 mg/kg/dose every 6 hours) in critically ill preterm neonates with patent ductus arteriosus: A prospective study.
Topics: Acetaminophen; Acute Kidney Injury; Administration, Intravenous; Birth Weight; Chemical and Drug Ind | 2021 |
Pain score assessment in babies undergoing laser treatment for retinopathy of prematurity under sub-tenon anaesthesia.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthesia, Local; Anesthetics, Local; Birth Weight; Chlora | 2013 |
Early paracetamol treatment associated with lowered risk of persistent ductus arteriosus in very preterm infants.
Topics: Acetaminophen; Birth Weight; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibuprofen; | 2014 |
Early paracetamol treatment associated with lowered risk of persistent ductus arteriosus in very preterm infants.
Topics: Acetaminophen; Birth Weight; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibuprofen; | 2014 |
Early paracetamol treatment associated with lowered risk of persistent ductus arteriosus in very preterm infants.
Topics: Acetaminophen; Birth Weight; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibuprofen; | 2014 |
Early paracetamol treatment associated with lowered risk of persistent ductus arteriosus in very preterm infants.
Topics: Acetaminophen; Birth Weight; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibuprofen; | 2014 |
Efficacy of paracetamol for the treatment of patent ductus arteriosus in preterm neonates.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Birth Weight; Dose-Response Relationship, Drug; Ductus Arte | 2014 |
Intravenous paracetamol with a lower dose is also effective for the treatment of patent ductus arteriosus in pre-term infants.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Birth Weight; Drug Administrat | 2015 |
Does intravenous paracetamol administration affect body temperature in neonates?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Birth Weight; Body Temperature; Cohort Studies; Drug Admini | 2011 |
Discomfort and pain in newborns with myelomeningocele: a prospective evaluation.
Topics: Acetaminophen; Analgesics, Opioid; Birth Weight; Cohort Studies; Confidence Intervals; Evidence-Base | 2012 |
Developmental pharmacokinetics of propylene glycol in preterm and term neonates.
Topics: Acetaminophen; Birth Weight; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Mo | 2013 |
Pharmacokinetics of single dose intravenous propacetamol in neonates: effect of gestational age.
Topics: Acetaminophen; Analgesia; Analgesics; Betamethasone; Birth Weight; Female; Gestational Age; Half-Lif | 2004 |
Reproductive toxicology. Acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Birth Weight; Body Weight; Dose-Response Relations | 1997 |
Reproductive toxicity evaluation of acetaminophen in Swiss CD-1 mice using a continuous breeding protocol.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Birth Weight; Body Weight; Breeding; Dose-Respo | 1992 |