acetaminophen has been researched along with Bilirubinemia in 18 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The use of acetaminophen in babies and young children may be much more strongly associated with autism than its use during pregnancy, perhaps because of well-known deficiencies in the metabolic breakdown of pharmaceuticals during early development." | 8.95 | The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism. ( Bilbo, S; Gentry, L; Herbert, MR; Holzknecht, ZE; Hornik, CD; Lin, SS; Nevison, CD; Parker, W; Rao, R, 2017) |
| " The use of acetaminophen in babies and young children may be much more strongly associated with autism than its use during pregnancy, perhaps because of well-known deficiencies in the metabolic breakdown of pharmaceuticals during early development." | 4.95 | The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism. ( Bilbo, S; Gentry, L; Herbert, MR; Holzknecht, ZE; Hornik, CD; Lin, SS; Nevison, CD; Parker, W; Rao, R, 2017) |
| " In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome." | 4.80 | Human UDP-glucuronosyltransferases: metabolism, expression, and disease. ( Strassburg, CP; Tukey, RH, 2000) |
| " However, recent case reports have suggested that acetaminophen concentrations may be falsely increased in the presence of hyperbilirubinemia." | 3.74 | False positive acetaminophen concentrations in patients with liver injury. ( Balko, JA; Fuller, D; Hynan, LS; Khan, AI; Koff, JM; Lee, WM; Murray, NG; Orsulak, P; Polson, J; Wians, FH, 2008) |
| "Acetaminophen was falsely detected in the plasma of a severely jaundiced patient, and a methodologic interference from bilirubin was suspected." | 3.72 | False-positive acetaminophen results in a hyperbilirubinemic patient. ( Bazooband, A; Bertholf, RL; Johannsen, LM; Mansouri, V, 2003) |
| " Mrp2 expression not only is important in biliary excretion, but also influences the toxic potential of reactive intermediates by controlling intrahepatic GSH and possibly drug metabolism." | 1.33 | Transport deficient (TR-) hyperbilirubinemic rats are resistant to acetaminophen hepatotoxicity. ( Chen, C; Manautou, JE; Silva, VM; Thibodeau, MS, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (44.44) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (38.89) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Tukey, RH | 1 |
| Strassburg, CP | 1 |
| James, J | 1 |
| Stauss, M | 1 |
| Ponnusamy, A | 1 |
| Myers, M | 1 |
| Parker, W | 1 |
| Hornik, CD | 1 |
| Bilbo, S | 1 |
| Holzknecht, ZE | 1 |
| Gentry, L | 1 |
| Rao, R | 1 |
| Lin, SS | 1 |
| Herbert, MR | 1 |
| Nevison, CD | 1 |
| Cardinale, M | 1 |
| Meyers, R | 1 |
| Craft, J | 1 |
| Bertholf, RL | 1 |
| Johannsen, LM | 1 |
| Bazooband, A | 1 |
| Mansouri, V | 1 |
| Chen, C | 2 |
| Hennig, GE | 1 |
| Manautou, JE | 2 |
| SILVERBERG, M | 1 |
| DESFORGES, J | 1 |
| GELLIS, S | 1 |
| Stolk, LM | 1 |
| Nelissen, B | 1 |
| van der Heijden, J | 1 |
| Beuhler, MC | 1 |
| Curry, SC | 1 |
| Silva, VM | 1 |
| Thibodeau, MS | 1 |
| Polson, J | 1 |
| Wians, FH | 1 |
| Orsulak, P | 1 |
| Fuller, D | 1 |
| Murray, NG | 1 |
| Koff, JM | 1 |
| Khan, AI | 1 |
| Balko, JA | 1 |
| Hynan, LS | 1 |
| Lee, WM | 1 |
| Duhamel, G | 1 |
| Najman, A | 1 |
| Gorin, NC | 1 |
| Lösgen, H | 1 |
| Brunner, G | 1 |
| Holloway, CJ | 1 |
| Büttelmann, B | 1 |
| Husmann, S | 1 |
| Scharff, P | 1 |
| Siehoff, A | 1 |
| Davidson, AR | 1 |
| Rojas-Bueno, A | 1 |
| Thompson, RP | 1 |
| Williams, R | 1 |
| Goranov, I | 1 |
| Avramova, K | 1 |
| Finlayson, NC | 1 |
| Pietsch, I | 2 |
| Gmyrek, D | 2 |
| David, H | 1 |
| Behrisch, D | 1 |
| Syllm-Rapoport, I | 1 |
| Kalz, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for acetaminophen and Bilirubinemia
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; | 2000 |
The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspartame; Autistic Disorder; Child; Child, Preschool; Fema | 2017 |
The adverse effects of drugs on the liver.
Topics: Acetaminophen; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Contraceptives, Oral; | 1973 |
15 other studies available for acetaminophen and Bilirubinemia
| Article | Year |
|---|---|
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Colitis, Ischemic; Colorimetry; Dimensional | 2020 |
Falsely elevated acetaminophen levels in a patient with extreme hyperbilirubinemia.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Bilirubin; Colorimetry; Humans; Hyperbilirubine | 2016 |
False-positive acetaminophen results in a hyperbilirubinemic patient.
Topics: Acetaminophen; Adolescent; Bilirubin; False Positive Reactions; Humans; Hyperbilirubinemia; Jaundice | 2003 |
Hepatobiliary excretion of acetaminophen glutathione conjugate and its derivatives in transport-deficient (TR-) hyperbilirubinemic rats.
Topics: Acetaminophen; Animals; Bile; Biotransformation; Chromatography, High Pressure Liquid; Hyperbilirubi | 2003 |
MECHANISMS UNDERLYING VITAMIN K INDUCED HYPERBILIRUBINEMIA IN PREMATURE INFANTS.
Topics: Acetaminophen; Acetanilides; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Bilirubin; Erythroc | 1963 |
False-positive acetaminophen results in hyperbilirubinemic patients with an enzymatic colorimetric assay.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chromatography, High Pressure Liquid; Colorimetry; False Po | 2003 |
False positive acetaminophen levels associated with hyperbilirubinemia.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Bilirubin; Enzyme Multiplied Immunoassay Technique; False P | 2005 |
Transport deficient (TR-) hyperbilirubinemic rats are resistant to acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; ATP-Binding Cassette Transporters; Buthionine Sulf | 2005 |
False positive acetaminophen concentrations in patients with liver injury.
Topics: Acetaminophen; Aged; Bilirubin; Drug Overdose; False Positive Reactions; Female; Humans; Hyperbiliru | 2008 |
[Current aspects of agranulocytosis (15 cases)].
Topics: Acetaminophen; Adult; Aged; Agranulocytosis; Ajmaline; Aminopyrine; Anti-Inflammatory Agents, Non-St | 1977 |
Large agarose beads for extracorporeal detoxification systems.
Topics: Acetaminophen; Animals; Bilirubin; Carrier Proteins; Ethanolamines; Hemoperfusion; Hepatic Encephalo | 1978 |
Early unconjugated hyperbilirubinaemia after paracetamol overdosage.
Topics: Acetaminophen; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Humans; Hyperbili | 1976 |
[Study of liver glucuronidase function in indirect hyperbilirubinemia and liver cirrhosis].
Topics: Acetaminophen; Bilirubin; Biological Transport; Free Radicals; Glucuronidase; Humans; Hyperbilirubin | 1975 |
[Paracetamol loading in the evaluation of the developing glucuronization function in premature infants].
Topics: Acetaminophen; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Premature; Liver Function Tests; | 1972 |
[Medicamentous prevention of hyperbilirubinemia of the newborn. II. Influence of the inductor phenylbutazone on loading with paracetamol in newborn].
Topics: Acetaminophen; Child; Chromatography, Thin Layer; Enzyme Induction; Glucuronates; Humans; Hyperbilir | 1971 |