acetaminophen has been researched along with Bile Duct Obstruction in 42 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen is used as first-choice drug for pain relief during pregnancy." | 7.80 | The effect of acetaminophen on the expression of BCRP in trophoblast cells impairs the placental barrier to bile acids during maternal cholestasis. ( Blazquez, AG; Briz, O; Ghanem, CI; Gonzalez-Sanchez, E; Marin, JJ; Perez, MJ, 2014) |
| "The possible relevance of alterations in intracellular Ca2+ and hepatic glutathione levels (GSH) in the pathogenesis of cholestasis induced by lithocholic acid (LCA) was examined by comparing effects of LCA and acetaminophen on these parameters and bile flow (BF) in rats." | 7.68 | Do intracellular Ca2+ activity and hepatic glutathione play a role in the pathogenesis of lithocholic acid-induced cholestasis? ( Plaa, GL; Tuchweber, B; Vu, DD; Yousef, IM, 1992) |
| "Administration of the non-metabolizable organic anion indocyanine green (ICG) prior to a toxic dose of acetaminophen (4-acetamidophenol; APAP) reduces liver injury 24h after dosing." | 5.33 | Cholestasis induced by model organic anions protects from acetaminophen hepatotoxicity in male CD-1 mice. ( Hennig, GE; Manautou, JE; Silva, VM, 2006) |
| "Acetaminophen is used as first-choice drug for pain relief during pregnancy." | 3.80 | The effect of acetaminophen on the expression of BCRP in trophoblast cells impairs the placental barrier to bile acids during maternal cholestasis. ( Blazquez, AG; Briz, O; Ghanem, CI; Gonzalez-Sanchez, E; Marin, JJ; Perez, MJ, 2014) |
| "The possible relevance of alterations in intracellular Ca2+ and hepatic glutathione levels (GSH) in the pathogenesis of cholestasis induced by lithocholic acid (LCA) was examined by comparing effects of LCA and acetaminophen on these parameters and bile flow (BF) in rats." | 3.68 | Do intracellular Ca2+ activity and hepatic glutathione play a role in the pathogenesis of lithocholic acid-induced cholestasis? ( Plaa, GL; Tuchweber, B; Vu, DD; Yousef, IM, 1992) |
| "Post-ALF cholestasis is ubiquitous." | 1.72 | Prevalence, severity, duration and resolution of cholestasis after acute liver failure. ( Bellomo, R; Gow, P; Holmes, N; Kishore, K; Marhoon, N; Michel, C; Serpa Neto, A; Sinclair, M; Testro, A; Warming, S; Warrillow, S, 2022) |
| " Cholestasis was significantly elevated in model mice when pretreatment with routine or high dosage of PRP, but had no effect on normal mice." | 1.48 | Pinelliae Rhizoma Praeparatum Involved in the Regulation of Bile Acids Metabolism in Hepatic Injury. ( Dang, X; Guo, S; Hu, N; Liu, L; Shi, L; Wei, H; Yang, P; Zhang, S; Zhang, Y, 2018) |
| " Appropriate dosing and managing of these drugs do not likely lead to organ toxicity." | 1.35 | Acute non-oliguric kidney failure and cholestatic hepatitis induced by ibuprofen and acetaminophen: a case report. ( Angeli, S; Brugnara, M; Cuzzolin, L; Zaffanello, M, 2009) |
| "Administration of the non-metabolizable organic anion indocyanine green (ICG) prior to a toxic dose of acetaminophen (4-acetamidophenol; APAP) reduces liver injury 24h after dosing." | 1.33 | Cholestasis induced by model organic anions protects from acetaminophen hepatotoxicity in male CD-1 mice. ( Hennig, GE; Manautou, JE; Silva, VM, 2006) |
| "Cholestasis was performed by bile duct ligation." | 1.30 | Drug glucuronidation and hepatic lipid microsomal membrane profile in cholestatic rats followed paracetamol intoxication. ( Acevedo, C; Bengochea, L; Ghanem, C; Ghisolfi, C; Lemberg, A; Marabotto, L; Mino, J; Perazzo, JC; Rubio, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (23.81) | 18.7374 |
| 1990's | 10 (23.81) | 18.2507 |
| 2000's | 8 (19.05) | 29.6817 |
| 2010's | 12 (28.57) | 24.3611 |
| 2020's | 2 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Dawson, S | 1 |
| Stahl, S | 1 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 1 |
| Warming, S | 1 |
| Michel, C | 1 |
| Serpa Neto, A | 1 |
| Kishore, K | 1 |
| Marhoon, N | 1 |
| Holmes, N | 1 |
| Bellomo, R | 1 |
| Testro, A | 1 |
| Sinclair, M | 1 |
| Gow, P | 1 |
| Warrillow, S | 1 |
| Oda, S | 1 |
| Hirabuki, Y | 1 |
| Takeuchi, T | 1 |
| Kagawa, T | 1 |
| Yokoi, T | 1 |
| Guo, S | 1 |
| Zhang, S | 1 |
| Liu, L | 1 |
| Yang, P | 1 |
| Dang, X | 1 |
| Wei, H | 1 |
| Hu, N | 1 |
| Shi, L | 1 |
| Zhang, Y | 1 |
| Ye, H | 1 |
| Nelson, LJ | 1 |
| Gómez Del Moral, M | 1 |
| Martínez-Naves, E | 1 |
| Cubero, FJ | 1 |
| Amathieu, R | 1 |
| Levesque, E | 1 |
| Merle, JC | 1 |
| Chemit, M | 1 |
| Costentin, C | 1 |
| Compagnon, P | 1 |
| Dhonneur, G | 1 |
| Blazquez, AG | 1 |
| Briz, O | 1 |
| Gonzalez-Sanchez, E | 1 |
| Perez, MJ | 1 |
| Ghanem, CI | 1 |
| Marin, JJ | 1 |
| Woolbright, BL | 2 |
| McGill, MR | 1 |
| Staggs, VS | 1 |
| Winefield, RD | 1 |
| Gholami, P | 1 |
| Olyaee, M | 1 |
| Sharpe, MR | 1 |
| Curry, SC | 1 |
| Lee, WM | 1 |
| Jaeschke, H | 2 |
| Harimoto, N | 1 |
| Wang, H | 1 |
| Ikegami, T | 1 |
| Takeishi, K | 1 |
| Itoh, S | 1 |
| Yamashita, YI | 1 |
| Yoshizumi, T | 1 |
| Aishima, S | 1 |
| Shirabe, K | 1 |
| Oda, Y | 1 |
| Maehara, Y | 1 |
| Zeng, H | 1 |
| Li, D | 1 |
| Qin, X | 1 |
| Chen, P | 1 |
| Tan, H | 1 |
| Zeng, X | 1 |
| Li, X | 1 |
| Fan, X | 1 |
| Jiang, Y | 1 |
| Zhou, Y | 1 |
| Chen, Y | 1 |
| Wang, Y | 1 |
| Huang, M | 1 |
| Bi, H | 1 |
| Vatakuti, S | 1 |
| Pennings, JL | 1 |
| Gore, E | 1 |
| Olinga, P | 1 |
| Groothuis, GM | 1 |
| Zaffanello, M | 1 |
| Brugnara, M | 1 |
| Angeli, S | 1 |
| Cuzzolin, L | 1 |
| Zamani, N | 1 |
| Mohammad Alizadeh, A | 1 |
| Maitta, RW | 1 |
| Choate, J | 1 |
| Emre, SH | 1 |
| Luczycki, SM | 1 |
| Wu, Y | 1 |
| Wong, F | 1 |
| Silva, VM | 1 |
| Hennig, GE | 1 |
| Manautou, JE | 1 |
| Perveze, Z | 1 |
| Johnson, MW | 1 |
| Rubin, RA | 1 |
| Sellers, M | 1 |
| Zayas, C | 1 |
| Jones, JL | 1 |
| Cross, R | 1 |
| Thomas, K | 1 |
| Butler, B | 1 |
| Shrestha, R | 1 |
| Kolts, BE | 1 |
| Langfitt, M | 1 |
| Mar, DD | 1 |
| Wardle, EN | 2 |
| Williams, R | 1 |
| Davies, MH | 1 |
| Ngong, JM | 1 |
| Yucesoy, M | 1 |
| Acharya, SK | 1 |
| Mills, CO | 1 |
| Weaver, JB | 1 |
| Waring, RH | 1 |
| Elias, E | 1 |
| Wong, V | 1 |
| Daly, M | 1 |
| Boon, A | 1 |
| Heatley, V | 1 |
| Acevedo, C | 2 |
| Bengochea, L | 4 |
| Tchercansky, DM | 1 |
| Ouviña, G | 1 |
| Perazzo, JC | 4 |
| Lago, N | 1 |
| Lemberg, A | 4 |
| Rubio, MC | 1 |
| Lindgren, A | 1 |
| Aldenborg, F | 1 |
| Norkrans, G | 1 |
| Olaison, L | 1 |
| Olsson, R | 2 |
| Mori, M | 1 |
| Suematsu, M | 1 |
| Kyokane, T | 1 |
| Sano, T | 1 |
| Suzuki, H | 1 |
| Yamaguchi, T | 1 |
| Ishimura, Y | 1 |
| Ishii, H | 1 |
| Ghanem, C | 3 |
| Ghisolfi, C | 3 |
| Scorticati, C | 2 |
| Marabotto, L | 1 |
| Mino, J | 1 |
| Rubio, M | 1 |
| Lewis, JH | 2 |
| Ryder, SD | 1 |
| Beckingham, IJ | 1 |
| Marino, G | 1 |
| Zimmerman, HJ | 1 |
| Sherlock, S | 1 |
| Talbot, IC | 1 |
| Arnman, R | 1 |
| Iwarson, S | 1 |
| Knoblauch, M | 1 |
| Lämmli, J | 1 |
| Funk, C | 1 |
| Waldum, HL | 1 |
| Hamre, T | 1 |
| Kleveland, PM | 1 |
| Dybdahl, JH | 1 |
| Petersen, H | 1 |
| Vu, DD | 1 |
| Tuchweber, B | 1 |
| Plaa, GL | 1 |
| Yousef, IM | 1 |
| Shukla, B | 1 |
| Visen, PK | 1 |
| Patnaik, GK | 1 |
| Dhawan, BN | 1 |
| Galinsky, RE | 1 |
| Chałasinska, B | 1 |
| Kaplowitz, N | 1 |
| Aw, TY | 1 |
| Simon, FR | 1 |
| Stolz, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for acetaminophen and Bile Duct Obstruction
| Article | Year |
|---|---|
Dissecting the molecular pathophysiology of drug-induced liver injury.
Topics: Acetaminophen; Adaptive Immunity; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug In | 2018 |
[Severe toxic acute liver failure: etiology and treatment].
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Anti-Infective Agents; Blood Coagulation Disorde | 2013 |
Sterile inflammation in acute liver injury: myth or mystery?
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Hepatitis; HMGB1 Protei | 2015 |
Emergency ABO-incompatible liver transplant secondary to fulminant hepatic failure: outcome, role of TPE and review of the literature.
Topics: ABO Blood-Group System; Acetaminophen; Acetylcysteine; Adult; Antibodies, Monoclonal, Murine-Derived | 2012 |
Liver and kidney diseases.
Topics: Acetaminophen; Anemia, Sickle Cell; Animals; Aspirin; Cholestasis; Cysts; Glomerulonephritis, IGA; G | 2002 |
Drug-induced liver disease.
Topics: Acetaminophen; Alanine Transaminase; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2000 |
ABC of diseases of liver, pancreas, and biliary system. Other causes of parenchymal liver disease.
Topics: Acetaminophen; Cholangitis, Sclerosing; Cholestasis; Drug Hypersensitivity; Hemochromatosis; Hepatit | 2001 |
Management of drug-induced liver disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cholestasis; Drug O | 2001 |
Acute liver injury.
Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Cholestasis; Halothane; Hepati | 1975 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Bile; Bile Acids and Salts; Biotransformation; Cell Survival; Chemical and Drug Induc | 1986 |
1 trial available for acetaminophen and Bile Duct Obstruction
| Article | Year |
|---|---|
The adverse influence of pregnancy upon sulphation: a clue to the pathogenesis of intrahepatic cholestasis of pregnancy?
Topics: Acetaminophen; Adult; Arylsulfotransferase; Blood Platelets; Cholestasis; Contraceptives, Oral; Estr | 1994 |
31 other studies available for acetaminophen and Bile Duct Obstruction
| Article | Year |
|---|---|
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Prevalence, severity, duration and resolution of cholestasis after acute liver failure.
Topics: Acetaminophen; Adult; Alkaline Phosphatase; Bilirubin; Cholestasis; gamma-Glutamyltransferase; Human | 2022 |
Plasma miR-218a-5p as a biomarker for acute cholestatic liver injury in rats and investigation of its pathophysiological roles.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis; Disease Mod | 2021 |
Pinelliae Rhizoma Praeparatum Involved in the Regulation of Bile Acids Metabolism in Hepatic Injury.
Topics: Acetaminophen; Angiogenic Proteins; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1 | 2018 |
The effect of acetaminophen on the expression of BCRP in trophoblast cells impairs the placental barrier to bile acids during maternal cholestasis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; ATP Binding Cassette Transporter, Subfamily B, Mem | 2014 |
Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients.
Topics: Acetaminophen; Adult; Biomarkers; Case-Control Studies; Chemical and Drug Induced Liver Injury; Chol | 2014 |
Education and imaging. Hepatology: Rare Stevens-Johnson syndrome and vanishing bile duct syndrome induced by acetaminophen, requiring liver transplantation.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Bile Ducts, Intrahepatic; Cholestasis; Dilat | 2015 |
Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid-Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Cytochrome P-450 CYP3A; | 2016 |
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.
Topics: Acetaminophen; Aged; Benzofurans; Bile Acids and Salts; Chloramphenicol; Chlorpromazine; Cholestasis | 2016 |
Acute non-oliguric kidney failure and cholestatic hepatitis induced by ibuprofen and acetaminophen: a case report.
Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury | 2009 |
Drug-induced cholestatic hepatitis: how late can it occur even after the cessation of the culpable drug?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antineoplastic Agents, Alkylating; Chemical and Drug Induce | 2012 |
Cholestasis induced by model organic anions protects from acetaminophen hepatotoxicity in male CD-1 mice.
Topics: Acetaminophen; Amaranth Dye; Animals; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Li | 2006 |
Terbinafine-induced hepatic failure requiring liver transplantation.
Topics: Acetaminophen; Antifungal Agents; Bile Ducts; Cholestasis; Humans; Liver; Liver Failure, Acute; Live | 2007 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |
Drug data: drug-induced hepatotoxicity.
Topics: Acetaminophen; Adult; Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Dose-Response Relat | 1982 |
Raised serum biliverdin in hepatic necrosis.
Topics: Acetaminophen; Animals; Bile Acids and Salts; Bilirubin; Biliverdine; Chemical and Drug Induced Live | 1981 |
Paracetamol and acute biliary pain with cholestasis.
Topics: Acetaminophen; Acute Disease; Adult; Cholestasis; Female; Humans; Pain | 1993 |
Cholestasis as a liver protective factor in paracetamol acute overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cholestasi | 1995 |
Paracetamol-induced cholestatic and granulomatous liver injuries.
Topics: Acetaminophen; Acute Disease; Adult; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcot | 1997 |
Carbon monoxide-mediated alterations in paracellular permeability and vesicular transport in acetaminophen-treated perfused rat liver.
Topics: Acetaminophen; Animals; Bile; Bilirubin; Carbon Monoxide; Cell Membrane Permeability; Cholestasis; C | 1999 |
[Benzodiazepines metabolism in various models of experimental liver diseases].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Benzodiazepines; Chemical and Drug | 1999 |
Drug glucuronidation and hepatic lipid microsomal membrane profile in cholestatic rats followed paracetamol intoxication.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bile Ducts; Cholestasis; Glucuronosyltransferase; | 1999 |
[Does TNF-alpha contribute to liver disease physiopathology?].
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2000 |
Hepatic reactions to drugs.
Topics: Acetaminophen; Adenoma; Adult; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1979 |
The clinical significance of increased plasma levels of liver-synthesized coagulation factors in liver disease.
Topics: Acetaminophen; Acute Disease; Biliary Tract Diseases; Blood Coagulation Factors; Chemical and Drug I | 1977 |
[Drug-induced liver diseases].
Topics: Acetaminophen; Adult; Alcoholism; Azathioprine; Bilirubin; Chemical and Drug Induced Liver Injury; C | 1975 |
Can NSAIDs cause acute biliary pain with cholestasis?
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Biliary Tract Diseases; Cholestasis; Codeine | 1992 |
Do intracellular Ca2+ activity and hepatic glutathione play a role in the pathogenesis of lithocholic acid-induced cholestasis?
Topics: Acetaminophen; Animals; Calcium; Cholestasis; Drug Synergism; Glutathione; Injections, Intravenous; | 1992 |
Choleretic effect of picroliv, the hepatoprotective principle of Picrorhiza kurroa.
Topics: Acetaminophen; Animals; Cholagogues and Choleretics; Cholestasis; Cinnamates; Female; Glycosides; Gu | 1991 |
Effect of taurolithocholate on in vivo sulfation and glucuronidation of acetaminophen in rats.
Topics: Acetaminophen; Animals; Cholestasis; Lithocholic Acid; Male; Rats; Rats, Inbred Strains; Taurolithoc | 1988 |
Fibrinogen in liver disease.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cholangitis; Cholestasis; Contusions; Endotox | 1974 |