acetaminophen and Bilateral Headache studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

Excerpt	Relevance	Reference
"To evaluate the efficacy of occipital nerve block compared with standard care , defined as acetaminophen with caffeine, for treatment of acute headache in pregnancy."	9.69	Occipital Nerve Block Compared With Acetaminophen and Caffeine for Headache Treatment in Pregnancy: A Randomized Controlled Trial. ( Blanchard, CT; Bushman, ET; Casey, BM; Cozzi, GD; Davis, AM; Digre, KB; Harper, L; Jones, B; Robbins, LS; Sinkey, RG; Szychowski, JM; Tita, AT, 2023)
"The aim of this study is to determine the efficacy of preemptive analgesia with paracetamol and ibuprofen to reduce the intensity and incidence of headache and myalgia after electroconvulsive therapy (ECT)."	9.30	Effects of preemptive intravenous paracetamol and ibuprofen on headache and myalgia in patients after electroconvulsive therapy: A placebo-controlled, double-blind, randomized clinical trial. ( Akbas, S; Karaaslan, E; Ozkan, AS; Zayman, EP, 2019)
"We investigated whether metoclopramide administered with diphenhydramine (MAD) relieves headache in pregnant women when acetaminophen alone is ineffective, using codeine for comparison."	9.27	Metoclopramide and Diphenhydramine: A Randomized Controlled Trial of a Treatment for Headache in Pregnancy when Acetaminophen Alone Is Ineffective (MAD Headache Study). ( Childress, KMS; Dothager, C; Gavard, JA; Laska, C; Lebovitz, S; Mostello, DJ, 2018)
"We conducted a single site, randomized, double-blind, placebo-controlled trial investigating the clinical efficacy of IV acetaminophen as an adjunct to a standard therapy with prochlorperazine and diphenhydramine for the treatment of patients who present to the ED with a chief complaint of "headache" or variants thereof."	9.24	Randomized Trial of Adding Parenteral Acetaminophen to Prochlorperazine and Diphenhydramine to Treat Headache in the Emergency Department. ( Hysell, MK; Meyering, SH; Stringer, RW, 2017)
"A significant reduction was seen in both the incidence and severity of post-ECT headache with preemptive analgesia with acetaminophen."	9.24	A randomized, double-blind, placebo-controlled trial on the role of preemptive analgesia with acetaminophen [paracetamol] in reducing headache following electroconvulsive therapy [ECT]. ( Ediriweera, D; Isuru, A; Kuruppuarachchi, L; Premadasa, S; Rodrigo, A; Wijesekara, C; Wijesinghe, C, 2017)
"Our study showed that both eletriptan and paracetamol relieve post-ECT headaches, but eletriptan showed superiority in reducing the intensity and duration of the headaches in this small treatment group."	9.20	Headache treatment after electroconvulsive treatment: a single-blinded trial comparator between eletriptan and paracetamol. ( Kertesz, DP; Trabekin, O; Vanetik, MS, 2015)
" To control for the confounding effects of analgesics, all patients received 650 mg acetaminophen for headache prophylaxis before each application."	9.17	Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study. ( Barish, CF; Berry, SM; Bhandari, R; Clark, G; Collins, GV; Howell, J; Pappas, JE; Riff, DS; Safdi, M; Yellowlees, A, 2013)
"The authors assessed the prevalence of headaches following extended-release dipyridamole/aspirin combination (DAC), and the efficacy of acetaminophen in the treatment of these headaches."	9.11	Acetaminophen in the treatment of headaches associated with dipyridamole-aspirin combination. ( Bigal, ME; Davidai, G; Gorelick, PB; Kolodner, KB; Lipton, RB; Schoebelock, M; Wilks, K, 2004)
"To investigate the effects of different doses of oral caffeine-paracetamol combinations in postdural puncture headache (PDPH) prophylaxis."	9.11	Oral multidose caffeine-paracetamol combination is not effective for the prophylaxis of postdural puncture headache. ( Akpinar, H; Esmaoglu, A; Uğur, F, 2005)
"Ibuprofen has been shown to be more effective than placebo in the treatment of high altitude headache (HAH), but nonsteroidal anti-inflammatory agents have been linked to increased incidence of gastrointestinal (GI) side effects and high-altitude pulmonary edema (HAPE)."	9.10	High altitude headache: efficacy of acetaminophen vs. ibuprofen in a randomized, controlled trial. ( Harris, NS; Thomas, SH; Wenzel, RP, 2003)
"This randomized, double-blind, placebo-controlled study compared the time to onset of analgesia and the analgesic efficacy of two formulations of acetaminophen 1000 mg--an effervescent solution and tablet--in 242 patients with moderate or severe pain following dental surgery."	9.09	Time to onset of analgesia and analgesic efficacy of effervescent acetaminophen 1000 mg compared to tablet acetaminophen 1000 mg in postoperative dental pain: a single-dose, double-blind, randomized, placebo-controlled study. ( Ganry, HE; Insuasty, JH; Møller, PL; Nørholt, SE; Sindet-Pedersen, S; Skoglund, LA; Vincent, FG, 2000)
"The aim of the study was to assess the efficacy and tolerability of a single oral dose of ketoprofen 25 mg in comparison with single doses of ketoprofen 2 x 25 mg, paracetamol 500 mg and 1,000 mg, and placebo in the treatment of episodic tension-type headache."	9.08	Ketoprofen, paracetamol and placebo in the treatment of episodic tension-type headache. ( Dahlöf, CG; Jacobs, LD, 1996)
" Using a double-blind placebo-controlled multiple crossover design, 53 patients with non-migrainous headaches were given placebo, acetaminophen, 2 doses of caffeine and 2 combinations of caffeine with acetaminophen."	9.07	The analgesic effects of caffeine in headache. ( Avery, D; Dunner, D; Ward, N; Whitney, C, 1991)
"A double-blind, randomized, multicenter investigation was conducted to compare the efficacy and safety of Fioricet, acetaminophen with codeine, and placebo for the symptomatic treatment of tension headache."	9.06	Symptomatic treatment of chronically recurring tension headache: a placebo-controlled, multicenter investigation of Fioricet and acetaminophen with codeine. ( DiSerio, FJ; Friedman, AP, 1987)
" The earlier review included 20 studies (7238 participants) in valid comparisons, but because we used different outcomes for some headache studies, the number of participants in the analyses of the effects of caffeine is now 4262 when previously it was 5243."	8.90	Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014)
" Most studies used paracetamol or ibuprofen, with 100 mg to 130 mg caffeine, and the most common pain conditions studied were postoperative dental pain, postpartum pain, and headache."	8.88	Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2012)
"Secondary outcome measures are postoperative pain intensity scores, psychological parameters, length of hospital stay and adverse events and will be reassessed at 3 and 6 months after surgery, with a baseline measurement preoperatively."	6.90	Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial. ( Bastiaenen, C; Bos, M; Colon, A; Dings, J; Hoogland, G; Rijkers, K; Rouhl, RPW; Schijns, OEMG; Sloekers, JCT; Theunissen, M; van Kuijk, S, 2019)
"To investigate the ability of a supranormal dose of N-acetylcysteine to overcome the effects of activated charcoal on N-acetylcysteine bioavailability and to determine the effects of activated charcoal on serum acetaminophen levels."	6.67	Use of activated charcoal in a simulated poisoning with acetaminophen: a new loading dose for N-acetylcysteine? ( Chamberlain, JM; Gorman, RL; Klein, BL; Klein-Schwartz, W; Oderda, GM, 1993)
"Recommendations for their use in treating headache should be based on individual patient suitability and on cost factors."	6.65	Comparison of 650 mg aspirin and 1,000 mg acetaminophen with each other, and with placebo in moderately severe headache. ( Fraim, CJ; Masel, BE; Peters, BH, 1983)
" Additional studies are needed to assess the relationship between caffeine dosing and clinical benefits in patients with TTH and migraine."	6.55	Caffeine in the management of patients with headache. ( Diener, HC; Garas, SY; Lipton, RB; Patel, K; Robbins, MS, 2017)
"To evaluate the efficacy of occipital nerve block compared with standard care , defined as acetaminophen with caffeine, for treatment of acute headache in pregnancy."	5.69	Occipital Nerve Block Compared With Acetaminophen and Caffeine for Headache Treatment in Pregnancy: A Randomized Controlled Trial. ( Blanchard, CT; Bushman, ET; Casey, BM; Cozzi, GD; Davis, AM; Digre, KB; Harper, L; Jones, B; Robbins, LS; Sinkey, RG; Szychowski, JM; Tita, AT, 2023)
"Acetaminophen is a widely used antipyretic drug."	5.33	Churg-Strauss syndrome associated with hypersensitivity to acetaminophen. ( Kawakami, M; Masuzawa, A; Moriguchi, M; Otsuka, M; Sugawara, H; Tabei, K; Tsuda, T; Yamada, S, 2005)
"The aim of this study is to determine the efficacy of preemptive analgesia with paracetamol and ibuprofen to reduce the intensity and incidence of headache and myalgia after electroconvulsive therapy (ECT)."	5.30	Effects of preemptive intravenous paracetamol and ibuprofen on headache and myalgia in patients after electroconvulsive therapy: A placebo-controlled, double-blind, randomized clinical trial. ( Akbas, S; Karaaslan, E; Ozkan, AS; Zayman, EP, 2019)
"We investigated whether metoclopramide administered with diphenhydramine (MAD) relieves headache in pregnant women when acetaminophen alone is ineffective, using codeine for comparison."	5.27	Metoclopramide and Diphenhydramine: A Randomized Controlled Trial of a Treatment for Headache in Pregnancy when Acetaminophen Alone Is Ineffective (MAD Headache Study). ( Childress, KMS; Dothager, C; Gavard, JA; Laska, C; Lebovitz, S; Mostello, DJ, 2018)
"A significant reduction was seen in both the incidence and severity of post-ECT headache with preemptive analgesia with acetaminophen."	5.24	A randomized, double-blind, placebo-controlled trial on the role of preemptive analgesia with acetaminophen [paracetamol] in reducing headache following electroconvulsive therapy [ECT]. ( Ediriweera, D; Isuru, A; Kuruppuarachchi, L; Premadasa, S; Rodrigo, A; Wijesekara, C; Wijesinghe, C, 2017)
"We conducted a single site, randomized, double-blind, placebo-controlled trial investigating the clinical efficacy of IV acetaminophen as an adjunct to a standard therapy with prochlorperazine and diphenhydramine for the treatment of patients who present to the ED with a chief complaint of "headache" or variants thereof."	5.24	Randomized Trial of Adding Parenteral Acetaminophen to Prochlorperazine and Diphenhydramine to Treat Headache in the Emergency Department. ( Hysell, MK; Meyering, SH; Stringer, RW, 2017)
"Our study showed that both eletriptan and paracetamol relieve post-ECT headaches, but eletriptan showed superiority in reducing the intensity and duration of the headaches in this small treatment group."	5.20	Headache treatment after electroconvulsive treatment: a single-blinded trial comparator between eletriptan and paracetamol. ( Kertesz, DP; Trabekin, O; Vanetik, MS, 2015)
" To control for the confounding effects of analgesics, all patients received 650 mg acetaminophen for headache prophylaxis before each application."	5.17	Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study. ( Barish, CF; Berry, SM; Bhandari, R; Clark, G; Collins, GV; Howell, J; Pappas, JE; Riff, DS; Safdi, M; Yellowlees, A, 2013)
"The Thomapyrin Study showed the significant superiority of the fixed combination of acetylsalicylic acid + paracetamol + caffeine over the combination without caffeine, the single preparations, and placebo in the treatment of headache."	5.16	Pain measurement: Visual Analogue Scale (VAS) and Verbal Rating Scale (VRS) in clinical trials with OTC analgesics in headache. ( Aicher, B; Diener, HC; Peil, B; Peil, H, 2012)
"To investigate the effects of different doses of oral caffeine-paracetamol combinations in postdural puncture headache (PDPH) prophylaxis."	5.11	Oral multidose caffeine-paracetamol combination is not effective for the prophylaxis of postdural puncture headache. ( Akpinar, H; Esmaoglu, A; Uğur, F, 2005)
"The authors assessed the prevalence of headaches following extended-release dipyridamole/aspirin combination (DAC), and the efficacy of acetaminophen in the treatment of these headaches."	5.11	Acetaminophen in the treatment of headaches associated with dipyridamole-aspirin combination. ( Bigal, ME; Davidai, G; Gorelick, PB; Kolodner, KB; Lipton, RB; Schoebelock, M; Wilks, K, 2004)
"Ibuprofen has been shown to be more effective than placebo in the treatment of high altitude headache (HAH), but nonsteroidal anti-inflammatory agents have been linked to increased incidence of gastrointestinal (GI) side effects and high-altitude pulmonary edema (HAPE)."	5.10	High altitude headache: efficacy of acetaminophen vs. ibuprofen in a randomized, controlled trial. ( Harris, NS; Thomas, SH; Wenzel, RP, 2003)
"This randomized, double-blind, placebo-controlled study compared the time to onset of analgesia and the analgesic efficacy of two formulations of acetaminophen 1000 mg--an effervescent solution and tablet--in 242 patients with moderate or severe pain following dental surgery."	5.09	Time to onset of analgesia and analgesic efficacy of effervescent acetaminophen 1000 mg compared to tablet acetaminophen 1000 mg in postoperative dental pain: a single-dose, double-blind, randomized, placebo-controlled study. ( Ganry, HE; Insuasty, JH; Møller, PL; Nørholt, SE; Sindet-Pedersen, S; Skoglund, LA; Vincent, FG, 2000)
"Infusion-related adverse events (IRAEs) such as nausea, vomiting, fever, chills, and thrombophlebitis that are associated with amphotericin B therapy often lead clinicians to prescribe a number of adjunctive pretreatment medications in an attempt to reduce the incidence and severity of these events."	5.08	Pretreatment regimens for adverse events related to infusion of amphotericin B. ( Cleary, JD; Goodwin, SD; Grasela, TH; Taylor, JW; Walawander, CA, 1995)
"The aim of the study was to assess the efficacy and tolerability of a single oral dose of ketoprofen 25 mg in comparison with single doses of ketoprofen 2 x 25 mg, paracetamol 500 mg and 1,000 mg, and placebo in the treatment of episodic tension-type headache."	5.08	Ketoprofen, paracetamol and placebo in the treatment of episodic tension-type headache. ( Dahlöf, CG; Jacobs, LD, 1996)
" Using a double-blind placebo-controlled multiple crossover design, 53 patients with non-migrainous headaches were given placebo, acetaminophen, 2 doses of caffeine and 2 combinations of caffeine with acetaminophen."	5.07	The analgesic effects of caffeine in headache. ( Avery, D; Dunner, D; Ward, N; Whitney, C, 1991)
"A double-blind, randomized, multicenter investigation was conducted to compare the efficacy and safety of Fioricet, acetaminophen with codeine, and placebo for the symptomatic treatment of tension headache."	5.06	Symptomatic treatment of chronically recurring tension headache: a placebo-controlled, multicenter investigation of Fioricet and acetaminophen with codeine. ( DiSerio, FJ; Friedman, AP, 1987)
"A double-blind, cross-over trial was made of three analgesic preparations--paracetamol, paracetamol with caffeine (Finimal) and aspirin in the relief of postoperative pain in 72 orthopedic inpatients and in 144 ambulatory outpatients suffering form common idiopathic headache."	5.04	A double-blind comparative evaluation of aspirin, paracetamol and paracetamol + caffeine (finimal) for their analgesic effectiveness. ( Lawczyński, L; Olszewska, M; Samochowiec, L; Szwed, G; Wójcicki, J, 1977)
"A patient-assessment of pain relief over 4 hours following a single dose of a compound analgesic has shown that 78% of patients achieve satisfactory relief of pain due to tension headache and that this response is enhanced by the addition of chlormezanone, an agent with reported anxiolytic and muscle relaxant actions."	5.04	A single dose placebo-controlled study to assess the effectiveness of adding a muscle relaxant to a compound analgesic in the treatment of tension headache. ( Atkinson, D, 1979)
"The effect of a new analgesic compound (propoxyphene, acetaminophen, caffeine, hydroxyzine) was investigated in a single-blind study comparing it with plain acetaminophen administered to forty patients with tension headache."	5.04	Study of a new analgesic compound in the treatment of tension headache. ( Borges, J; Zavaleta, C, 1976)
" The earlier review included 20 studies (7238 participants) in valid comparisons, but because we used different outcomes for some headache studies, the number of participants in the analyses of the effects of caffeine is now 4262 when previously it was 5243."	4.90	Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014)
" Most studies used paracetamol or ibuprofen, with 100 mg to 130 mg caffeine, and the most common pain conditions studied were postoperative dental pain, postpartum pain, and headache."	4.88	Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2012)
" For the acute treatment of migraine attacks or tension-type headache, ibuprofen (10 mg per kg body weight) or acetaminophen (15 mg per kg body weight) are recommended with highest evidence, intranasal sumatriptan (10 to 20 mg) can be given as second choice."	4.81	[Treatment of idiopathic headache in childhood - recommendations of the German Migraine and Headache Society (DMKG)]. ( Evers, S; Gerber, WD; Naumann, E; Pothmann, R; Uberall, M, 2002)
"This study investigates whether acute treatment with ibuprofen, acetaminophen, or both is associated with resolution of headache or reduction of headache pain at 7 days post-concussion in children and youth."	4.12	Early analgesic administration and headache presence 7 days post-concussion in children. ( Bell, MJ; Boutis, K; Freedman, SB; Gravel, J; Ledoux, A-; Mannix, RC; Richer, LR; Tang, K; Yeates, KO; Zemek, RL, 2022)
"A prediction model development study was completed using the 2006 American Migraine Prevalence and Prevention Study survey, from participants who were aged ≥18, met criteria and headache day frequency for episodic migraine, did not take prescription medication for migraine, and used ≥1 of the following acute migraine medication classes: acetaminophen, aspirin, NSAIDs, or caffeine containing combination products (CCP)."	4.12	Predictive models for determining treatment response to nonprescription acute medications in migraine: Results from the American Migraine Prevalence and Prevention Study. ( Armand, CE; Buse, DC; Ezzati, A; Fanning, KM; Lipton, RB; Martin, VT; Pavlovic, JM; Reed, ML, 2022)
" In this study, we also evaluate three "budget" over-the-counter headache medications (subsequently labeled as brands A, B, and C) for agglomeration of the three APIs in the formulation: Acetaminophen, aspirin, and caffeine."	4.02	Diagnosis of Agglomeration and Crystallinity of Active Pharmaceutical Ingredients in Over the Counter Headache Medication by Electrospray Laser Desorption Ionization Mass Spectrometry Imaging. ( Dimmitt, NH; Green, AM; Hubbard, ND; Khan, SM; McVey, PA; Taulbee-Cotton, BV; Van Meter, MI; Webster, GK, 2021)
"In spite of clinical differences between transformed migraine and tension headache, which may help diagnosis, in our series abuse of analgesics (including ergotamine) was a common characteristic."	3.69	[Clinical features of daily chronic headache]. ( Iñiguez, C; Larrodé, P; Mauri, JA; Morales, F, 1997)
"Two commonly taken over-the-counter analgesics, aspirin and acetaminophen, were compared for: effect on total menstrual loss, effect on total days of menstruation, and effect in reduction of pain due to headaches and/or menstrual cramps."	3.67	Do aspirin and acetaminophen affect total menstrual loss? ( Agna, MA; Pendergrass, PB; Ream, LJ; Scott, JN, 1984)
"Secondary outcome measures are postoperative pain intensity scores, psychological parameters, length of hospital stay and adverse events and will be reassessed at 3 and 6 months after surgery, with a baseline measurement preoperatively."	2.90	Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial. ( Bastiaenen, C; Bos, M; Colon, A; Dings, J; Hoogland, G; Rijkers, K; Rouhl, RPW; Schijns, OEMG; Sloekers, JCT; Theunissen, M; van Kuijk, S, 2019)
" In both studies, a high-fat meal did not affect the Cmax for hydrocodone."	2.80	Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials. ( Devarakonda, K; Giuliani, MJ; Kostenbader, K; Young, JL, 2015)
"Because headache is a common side effect of electroconvulsive therapy (ECT), this study sought to determine the effectiveness of cryotherapy (i."	2.71	Cryotherapy for treatment of ECT-induced headache. ( Callahan, L; Drew, BI; King, ML, 2005)
"Isradipine dose was 30 mg sustained release nightly plus 15 mg immediate release 2 hr before cocaine infusion."	2.71	Effects of repeated-dose isradipine on the abuse liability of cocaine. ( Ait-Daoud, N; Johnson, BA; Mauldin, JB; Murff, WL; Roache, JD; Thornton, JE; Wells, LT, 2005)
" Somnolence, fatigue, and nausea were the most common volunteered adverse events; only somnolence was significantly greater after CPA than after either PA or placebo."	2.71	Efficacy and safety of clemastine-pseudoephedrine-acetaminophen versus pseudoephedrine-acetaminophen in the treatment of seasonal allergic rhinitis in a 1-day, placebo-controlled park study. ( Casale, TB; del Rio, E; Gold, MS; Meltzer, EO; O'Connor, R; Reitberg, D; Weiler, JM; Weiler, K, 2003)
"Ibuprofen is a peripherally acting nonsteroidal anti-inflammatory drug indicated fo ranalgesia, antipyresis, and various arthritic conditions."	2.70	Onset of analgesia for liquigel ibuprofen 400 mg, acetaminophen 1000 mg, ketoprofen 25 mg, and placebo in the treatment of postoperative dental pain. ( Cooper, S; Doyle, G; Jayawardena, S; Marrero, I; Olson, NZ; Otero, AM; Sunshine, A; Tirado, S, 2001)
"Acetaminophen may have been blunted some adverse effects."	2.70	Adverse effects of superactivated charcoal administered to healthy volunteers. ( Sato, RL; Sumida, SM; Wong, JJ; Yamamoto, LG, 2002)
"It was confirmed that headache as a pain model does not show the usual return of pain with as the effects of a single analgesic dose wear off."	2.67	Evaluation of analgesic agents in recurring headache compared with other clinical pain models. ( Aimola, N; Gawel, MJ; Stiglick, A; Szalai, JF; Weiner, M, 1990)
"To investigate the ability of a supranormal dose of N-acetylcysteine to overcome the effects of activated charcoal on N-acetylcysteine bioavailability and to determine the effects of activated charcoal on serum acetaminophen levels."	2.67	Use of activated charcoal in a simulated poisoning with acetaminophen: a new loading dose for N-acetylcysteine? ( Chamberlain, JM; Gorman, RL; Klein, BL; Klein-Schwartz, W; Oderda, GM, 1993)
"Recommendations for their use in treating headache should be based on individual patient suitability and on cost factors."	2.65	Comparison of 650 mg aspirin and 1,000 mg acetaminophen with each other, and with placebo in moderately severe headache. ( Fraim, CJ; Masel, BE; Peters, BH, 1983)
"Headache is an increasingly common symptom among children and adolescents with a prevalence of 58."	2.58	[Headache in children and adolescents]. ( Debes, NM; Gren, C; Miranda, M; Vogler, K, 2018)
" Additional studies are needed to assess the relationship between caffeine dosing and clinical benefits in patients with TTH and migraine."	2.55	Caffeine in the management of patients with headache. ( Diener, HC; Garas, SY; Lipton, RB; Patel, K; Robbins, MS, 2017)
"Medication overuse headache is a common feature underlying chronic headache, especially migraine."	2.44	Medication overuse headache. ( Couch, JR; Lenaerts, ME, 2007)
"Most headaches are benign, but all require appropriate assessment."	2.41	"Nurse, my head hurts": a review of childhood headaches. ( Fisher, W; Gordon, V; Kolar, KR, 2001)
"Two cases (spouses) of carcinoma of the ureter possibly induced by long-term use of analgesic were presented."	2.38	[Carcinoma of the ureter after long-term use of analgesic [phenacetin derivative]--report of the two cases (spouses)]. ( Marouka, M; Miyauchi, T; Nagayama, T; Wakatsuki, S, 1990)
"Severe headaches are common after subarachnoid hemorrhage."	1.91	Acute Headache Management for Patients with Subarachnoid Hemorrhage: An International Survey of Health Care Providers. ( Abu-Mowis, Z; Aspide, R; Barlow, B; Bilotta, F; Busl, KM; Citerio, G; Dickinson, K; Gobinathan, A; Lucke-Wold, B; Maciel, CB; Merck, LH; Miao, G; Morris, NA; Peethala, MM; Shan, G, 2023)
"Prochlorperazine injection has been upgraded to a highly recommended level because of the rich clinical experience for this treatment."	1.72	2022 Taiwan Guidelines for Acute Treatment of Migraine. ( Lau, CI; Wang, YF, 2022)
"Headache is the most common COVID-19-related neurological symptom."	1.72	Patterns of COVID-19-related headache: A cross-sectional study. ( Celikbilek, A; Hizmali, L; Kocak, Y; Sahin, BE, 2022)
"Fifty children, with 116 migraine attacks, were included in the study (30 females; mean age 12; range 6-18)."	1.72	Migraine abortive treatment in children and adolescents in Israel. ( Cohen, R; Genizi, J; Lahoud, D, 2022)
"Women with preeclampsia had used significantly more often paracetamol during pregnancy compared to controls (cases 8."	1.62	Increased risk of preeclampsia after use of paracetamol during pregnancy - causal or coincidence? ( Keski-Nisula, L; Sahlman, H; von Hellens, H, 2021)
"Acupuncture is a promising method in treatment of headaches associated with meningeal sensitivity or irritation, such as migraine or post-dural puncture headache."	1.51	Treating Therapy-Resistant Headache After Aneurysmal Subarachnoid Hemorrhage with Acupuncture. ( Dietzel, J; Eck, T; Usichenko, T, 2019)
"Cerebral venous thrombosis (CVT) is a rare, difficult-to-diagnose form of venous thromboembolic disease and is considered a type of stroke."	1.51	Cerebral Venous Thrombosis: An Uncommon Cause of Papilledema on Bedside Ocular Ultrasound. ( Arthur, J; Chadwick, S; Duran-Gehring, P; Kumetz, C; McIntosh, M, 2019)
"Headache is a common chronic neurologic disorder with huge economic and psychosocial impact."	1.46	Prevalence and clinical characteristics of headaches among undergraduate students in three tertiary institutions in Ilorin, Nigeria. ( Aderibigbe, SA; Adeyanju, OA; Desalu, OO; Kolo, PM; Mustapha, AF; Sanya, EO, 2017)
"Migraine is common in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) but its treatment responses are not well described, and its relationship to stroke risk unknown."	1.43	CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships. ( Markus, HS; Tan, RY, 2016)
" The most common information provided was dosage and adverse effects."	1.38	Using the simulated patient methodology to assess paracetamol-related counselling for headache. ( Horvat, N; Koder, M; Kos, M, 2012)
"This study identified underdiagnosis of migraine, low use of migraine prophylaxis and triptans, and high prevalence of medication overuse among subjects seeking self-medication for regular headache."	1.38	[Self-medication of regular headache: a community pharmacy-based survey in Belgium]. ( Boussery, K; Christiaens, T; De Bolle, L; Evrard, B; Mehuys, E; Paemeleire, K; Philippe, G; Piette, M; Prévôt, ML; Remon, JP; Van Bortel, L; Van Hees, T; Van Tongelen, I, 2012)
"Childhood headache is a common condition."	1.36	[Update on current care guidelines; childhood headache]. ( , 2010)
"Giant cell arteritis (GCA), also called temporal arteritis, is a systemic inflammatory vasculitis of unknown etiology that affects medium- and large-sized arteries."	1.35	Hyperostosis frontalis interna in a patient with giant cell arteritis. ( Butun, B; Gurbuz, U; Illeez, O; Kocabas, H; Melikoglu, MA; Ozbudak, IH; Sezer, I, 2008)
"Acetaminophen is a widely used antipyretic drug."	1.33	Churg-Strauss syndrome associated with hypersensitivity to acetaminophen. ( Kawakami, M; Masuzawa, A; Moriguchi, M; Otsuka, M; Sugawara, H; Tabei, K; Tsuda, T; Yamada, S, 2005)
"Aspirin was used by 7."	1.33	Use and misuse of aspirin in rural Ethiopia. ( Aref-Adib, G; Britton, J; Davey, G; Duncan, P; Venn, A, 2006)
" In contrast to acute renal insufficiency that may already occur after a single NSAID dose, analgesic nephropathy is a disease caused by long-term intake of NSAID compound analgesics and predominantly affects the middle and old age."	1.33	[Chronic interstitial nephritis in an 18-year-old due to intake of a compound analgesic]. ( Janssen, U; Jochum, E, 2006)
"Short attacks of headache are present in the pediatric age group and are not easily classified according to the International Headache Society criteria."	1.32	Idiopathic stabbing headache: clinical characteristics of children and adolescents. ( Faienza, C; Fusco, C; Pisani, F, 2003)
" The specific objectives of research are to identify physiologic, pharmacokinetic, and pharmacodynamic changes in space; to develop simple, reliable, non-invasive, safe and effective acute and sustained-release dosage forms and regimens for pharmacological interventions in space; and to create and maintain a comprehensive space PK-PD and therapeutics database."	1.30	Pharmacotherapeutics in space. ( Putcha, L, 1999)
"The long-term effects of substance abuse are contingent on the compounds that are used."	1.28	Drug abuse and headache. ( Elkind, AH, 1991)
"Aspirin prescriptions were consistent over the entire study period among inpatients, but preadmission use decreased substantially."	1.26	Acetaminophen and aspirin. Prescription, use, and accidental ingestion among children. ( Lovejoy, FH; Mitchell, AA; Shapiro, S; Slone, D, 1982)

Research

Studies (137)

Authors

Clinical Trials (8)

Trial Overview

Trial Outcomes

Duration of Headache Free Period at 7 Days

Number of Participants With Development of Hypertensive Disease of Pregnancy Within 28 Days

Number of Participants With Development of Hypertensive Disease of Pregnancy Within 7 Days

Number of Participants With Injection Site Complication (Infection, Hematoma, and Ecchymosis)

Number of Participants With Need for Admission for Treatment of Headache

Number of Participants With Need for Crossover Treatment

Number of Participants With Need for Neurology Consult

Number of Participants With Need for Representation for Treatment of Headache With 28 Days

Timeframe	Studies, this research(%)	All Research%
pre-1990	29 (21.17)	18.7374
1990's	24 (17.52)	18.2507
2000's	36 (26.28)	29.6817
2010's	32 (23.36)	24.3611
2020's	16 (11.68)	2.80

Authors	Studies
Kazama, I	1
Senzaki, M	1
Genizi, J	1
Lahoud, D	1
Cohen, R	1
Ezzati, A	1
Fanning, KM	1
Buse, DC	1
Pavlovic, JM	1
Armand, CE	1
Reed, ML	1
Martin, VT	1
Lipton, RB	4
Sahin, BE	1
Celikbilek, A	1
Kocak, Y	1
Hizmali, L	1
Nelson, R	1
Kittel-Moseley, J	1
Mahoui, I	1
Thornberry, D	1
Dunkman, A	1
Sams, M	1
Adler, D	1
Jones, CMC	1
Maciel, CB	1
Barlow, B	1
Lucke-Wold, B	1
Gobinathan, A	1
Abu-Mowis, Z	1
Peethala, MM	1
Merck, LH	1
Aspide, R	1
Dickinson, K	1
Miao, G	1
Shan, G	1
Bilotta, F	1
Morris, NA	1
Citerio, G	1
Busl, KM	1
Ledoux, A-	1
Tang, K	1
Freedman, SB	1
Gravel, J	1
Boutis, K	1
Yeates, KO	1
Mannix, RC	1
Richer, LR	1
Bell, MJ	1
Zemek, RL	1
Lau, CI	1
Wang, YF	1
Bushman, ET	1
Blanchard, CT	1
Cozzi, GD	1
Davis, AM	1
Harper, L	1
Robbins, LS	1
Jones, B	1
Szychowski, JM	1
Digre, KB	1
Casey, BM	1
Tita, AT	1
Sinkey, RG	1
Sloekers, JCT	1
Bos, M	1
Hoogland, G	1
Bastiaenen, C	1
van Kuijk, S	1
Theunissen, M	1
Rijkers, K	1
Dings, J	1
Colon, A	1
Rouhl, RPW	1
Schijns, OEMG	1
Karaaslan, E	1
Akbas, S	1
Ozkan, AS	1
Zayman, EP	1
Feldhausen, D	1
Cankaya, S	1
Oktem, EO	1
Saatci, O	1
Velioglu, HA	1
Uygur, AB	1
Ozsimsek, A	1
Hanoglu, L	1
Yulug, B	1
Sibley, AK	1
Atkinson, P	1
Shayne, P	1
Costa, FM	1
Ferreira, IP	1
Mascarenhas, IF	1
Alves, CF	1
Bento, VA	1
Loureiro, HC	1
von Hellens, H	1
Keski-Nisula, L	1
Sahlman, H	1
Van Meter, MI	1
Khan, SM	1
Taulbee-Cotton, BV	1
Dimmitt, NH	1
Hubbard, ND	1
Green, AM	1
Webster, GK	1
McVey, PA	1
Meyering, SH	1
Stringer, RW	1
Hysell, MK	1
Subedi, Y	1
Isuru, A	1
Rodrigo, A	1
Wijesinghe, C	1
Ediriweera, D	1
Premadasa, S	1
Wijesekara, C	1
Kuruppuarachchi, L	1
Diener, HC	2
Robbins, MS	1
Garas, SY	1
Patel, K	1
Sanya, EO	1
Desalu, OO	1
Aderibigbe, SA	1
Kolo, PM	1
Mustapha, AF	1
Adeyanju, OA	1
Gren, C	1
Vogler, K	1
Miranda, M	1
Debes, NM	1
Ros Forteza, FJ	1
Konkel, L	1
Childress, KMS	1
Dothager, C	1
Gavard, JA	1
Lebovitz, S	1
Laska, C	1
Mostello, DJ	1
Arthur, J	1
Duran-Gehring, P	1
Kumetz, C	1
Chadwick, S	1
McIntosh, M	1
Dietzel, J	1
Eck, T	1
Usichenko, T	1
Berry, SM	1
Barish, CF	1
Bhandari, R	1
Clark, G	1
Collins, GV	1
Howell, J	1
Pappas, JE	1
Riff, DS	1
Safdi, M	1
Yellowlees, A	1
Slim, R	1
Fathallah, N	1
Aounallah, A	1
Ksiaa, M	1
Sriha, B	1
Nouira, R	1
Ben Salem, C	1
Kertesz, DP	1
Trabekin, O	1
Vanetik, MS	1
Derry, CJ	2
Derry, S	2
Moore, RA	2
Devarakonda, K	1
Kostenbader, K	1
Giuliani, MJ	1
Young, JL	1
Bohio, R	1
Brohi, ZP	1
Bohio, F	1
Bui, SB	1
Petersen, T	1
Poulsen, JN	1
Gazerani, P	1
Tan, RY	1
Markus, HS	1
Sussman, NL	1
Remien, CH	1
Ahluwalia, M	1
Hughes, AM	1
McCracken, LM	1
Chilcot, J	1
Sahai-Srivastava, S	1
Desai, P	1
Zheng, L	1
Hocevar, S	1
Kennedy, SA	1
Darden, PM	1
Reigart, JR	1
Lavie, L	1
López Abad, R	1
Iriarte Sotés, P	1
Castro Murga, M	1
Gracia Bara, MT	1
Sesma Sánchez, P	1
Manzano, S	1
Doyon-Trottier, E	1
Bailey, B	1
Zyoud, SH	1
Awang, R	1
Sulaiman, SA	1
Al-Jabi, SW	1
Sandhu, T	1
Paiboonworachat, S	1
Ko-iam, W	1
Wark, JD	1
Bensen, W	1
Recknor, C	1
Ryabitseva, O	1
Chiodo, J	1
Mesenbrink, P	1
de Villiers, TJ	1
Aicher, B	1
Peil, H	1
Peil, B	1
Schenk, JM	1
Calip, GS	1
Tangen, CM	1
Goodman, P	1
Parsons, JK	1
Thompson, IM	1
Kristal, AR	1
Mehuys, E	1
Paemeleire, K	1
Van Hees, T	1
Christiaens, T	1
Van Bortel, L	1
Van Tongelen, I	1
Philippe, G	1
Prévôt, ML	1
Evrard, B	1
Piette, M	1
De Bolle, L	1
Remon, JP	1
Boussery, K	1
Horvat, N	1
Koder, M	1
Kos, M	1
Imperato, J	1
Burstein, J	1
Edlow, JA	1
Sato, RL	1
Wong, JJ	1
Sumida, SM	1
Yamamoto, LG	1
Meltzer, EO	1
Casale, TB	1
Gold, MS	1
O'Connor, R	1
Reitberg, D	1
del Rio, E	1
Weiler, JM	1
Weiler, K	1
Harris, NS	1
Wenzel, RP	1
Thomas, SH	1
Fusco, C	1
Pisani, F	1
Faienza, C	1
Yildirim, RC	1
OGDEN, HD	1
SCHOCKET, L	1
Roth, LS	1
Jafri, SH	1
Cook, JW	1
Reed, RR	1
Beebe, DK	1
Río, J	1
Nos, C	1
Bonaventura, I	1
Arroyo, R	1
Genis, D	1
Sureda, B	1
Ara, JR	1
Brieva, L	1
Martín, J	1
Saiz, A	1
Sánchez López, F	1
Prieto, JM	1
Roquer, J	1
Dorado, JF	1
Montalban, X	1
Bigal, ME	1
Kolodner, KB	1
Gorelick, PB	1
Wilks, K	1
Schoebelock, M	1
Davidai, G	1
Esmaoglu, A	1
Akpinar, H	1
Uğur, F	1
Hoito, K	1
Drew, BI	1
King, ML	1
Callahan, L	1
Hämäläinen, M	1
Masuzawa, A	1
Moriguchi, M	1
Tsuda, T	1
Sugawara, H	1
Otsuka, M	1
Yamada, S	1
Tabei, K	1
Kawakami, M	1
Roache, JD	1
Johnson, BA	1
Ait-Daoud, N	1
Mauldin, JB	1
Thornton, JE	1
Wells, LT	1
Murff, WL	1
Duncan, P	1
Aref-Adib, G	1
Venn, A	1
Britton, J	1
Davey, G	1
Steiner, TJ	1
Jochum, E	1
Janssen, U	1
Tfelt-Hansen, P	1
Vadivel, N	1
Trikudanathan, S	1
Singh, AK	1
Ducros, A	1
Lenaerts, ME	1
Couch, JR	1
Kocabas, H	1
Sezer, I	1
Melikoglu, MA	1
Gurbuz, U	1
Illeez, O	1
Ozbudak, IH	1
Butun, B	1
Hogan, RP	1
Peters, BH	1
Fraim, CJ	1
Masel, BE	1
Laska, EM	1
Sunshine, A	2
Mueller, F	1
Elvers, WB	1
Siegel, C	1
Rubin, A	1
Pendergrass, PB	2
Ream, LJ	2
Scott, JN	2
Agna, MA	2
Blau, JN	1
Mitchell, AA	1
Lovejoy, FH	1
Slone, D	1
Shapiro, S	1
Muscat, JE	1
Stellman, SD	1
Wynder, EL	1
Goodwin, SD	1
Cleary, JD	1
Walawander, CA	1
Taylor, JW	1
Grasela, TH	1
Koehler, PJ	1
Mulder, LJ	1
Hartleb, M	2
Nowak, A	1
Romańczyk, T	1
Kasicka-Jonderko, A	1
Januszewski, K	1
Chamberlain, JM	1
Gorman, RL	1
Oderda, GM	1
Klein-Schwartz, W	1
Klein, BL	1
Raskin, N	1
Ruoff, G	1
Saper, J	1
Sheftell, F	1
Solomon, S	1
Dahlöf, CG	1
Jacobs, LD	1
Göbel, H	1
Fresenius, J	1
Heinze, A	1
Dworschak, M	1
Soyka, D	1
Hindmarsh, JT	1
Joseph, R	1
Iñiguez, C	1
Larrodé, P	1
Mauri, JA	1
Morales, F	1
Martínez Albuixech, P	1
Symon, DN	1
Van de Velde, M	1
Corneillie, M	1
Vanacker, B	1
Stevens, E	1
Verhaeghe, J	1
Van Assche, A	1
Vandermeersch, E	1
Møller, PL	1
Nørholt, SE	1
Ganry, HE	1
Insuasty, JH	1
Vincent, FG	1
Skoglund, LA	1
Sindet-Pedersen, S	1
Irion, R	1
Gall, H	1
Werfel, T	1
Peter, RU	1
Putcha, L	1
Olson, NZ	1
Otero, AM	1
Marrero, I	1
Tirado, S	1
Cooper, S	1
Doyle, G	1
Jayawardena, S	1
Evers, S	1
Pothmann, R	1
Uberall, M	1
Naumann, E	1
Gerber, WD	1
Kolar, KR	1
Fisher, W	1
Gordon, V	1
Reess, J	1
Haas, J	1
Gabriel, K	1
Fuhlrott, A	1
Fiola, M	1
Moral Turiel, M	1
Rodríguez Simón, MO	1
Sahagún de la Lastra, J	1
Yuste Pascual, JA	1
Calero Muñoz, S	1
Fariñas Balaguer, O	1
Nieto Márquez, L	1
Cobo Guerrero, S	1
Wójcicki, J	1
Samochowiec, L	1
Lawczyński, L	1
Szwed, G	1
Olszewska, M	1
Kagan, G	1
Masheter, HC	1
Atkinson, D	1
Borges, J	1
Zavaleta, C	1
Gilbert, MM	1
De Sola Pool, N	1
Schecter, C	1
Luján, M	1
López-Fiesco, A	1
Lopez y Martínez, E	1
Zamora Lopez, G	1
Alvarez Rueda, M	1
Faithfull, NS	1
Schachtel, BP	1
Thoden, WR	1
Konerman, JP	1
Brown, A	1
Chaing, DS	1
Elkind, AH	1
Scherber, A	1
Ward, N	1
Whitney, C	1
Avery, D	1
Dunner, D	1
Miyauchi, T	1
Marouka, M	1
Nagayama, T	1
Wakatsuki, S	1
Gawel, MJ	1
Szalai, JF	1
Stiglick, A	1
Aimola, N	1
Weiner, M	1
Sandler, DP	1
Smith, JC	1
Weinberg, CR	1
Buckalew, VM	1
Dennis, VW	1
Blythe, WB	1
Burgess, WP	1
Miller, DS	1
Talbot, CA	1
Simpson, W	1
Korey, A	1
Friedman, AP	1
DiSerio, FJ	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Comparison of Paracetamol and Dexketoprofen Trometamol on Headache Treatment After Electroconvulsive Treatment[NCT03830398]	Phase 4	225 participants (Anticipated)	Interventional	2018-11-20	Recruiting
Acute Headache Treatment in Pregnancy: Improvement in Pain Scores With Occipital Nerve Block vs PO Acetaminophen With Caffeine A Randomized Controlled Trial[NCT03951649]	Phase 4	62 participants (Actual)	Interventional	2020-02-10	Completed
A Randomized. Double-blind, Placebo-controlled, Multi-national Study to Determine the Effect of Cellegesic Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With a Chronic Anal Fissure[NCT00522041]	Phase 3	248 participants (Actual)	Interventional	2007-08-31	Completed
An Open-Label, Randomized, Single-Dose, Three-Period Crossover Study to Evaluate the Pharmacokinetics, Bioavailability, and Safety of COV155 Administered in Normal, Healthy Subjects Under Fed (High- and Low-Fat Meal) and Fasted Conditions[NCT02561650]	Phase 1	48 participants (Actual)	Interventional	2011-12-31	Completed
An Open-Label, Randomized, Single-Dose, Three-Period Crossover Study to Evaluate the Pharmacokinetics, Bioavailability, and Safety of 3 Tablets of COV155 Administered in Normal, Healthy Subjects Under Fed (High- and Low-Fat Meal) and Fasted Conditions[NCT02561741]	Phase 1	30 participants (Actual)	Interventional	2012-12-31	Completed
Use of IV Acetaminophen Intraoperatively in Obese Patients at Risk for Obstructive Sleep Apnea Undergoing Laparoscopic Cholecystectomy[NCT02056678]	Phase 4	0 participants (Actual)	Interventional	2014-02-28	Withdrawn (stopped due to Investigator left institution)
Acute Mountain Sickness Treatment: A Double-blind Comparison of Metoclopramide vs. Ibuprofen[NCT01522326]		300 participants (Anticipated)	Interventional	2012-03-01	Completed
A Trial of Prednisone and Acetaminophen Versus Acetaminophen Alone in Minimizing Flu-like Symptoms From Pegylated Interferon Beta-1a[NCT03424733]	Phase 4	50 participants (Anticipated)	Interventional	2017-09-25	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	days (Median)
Occipital Nerve Block	6
Oral Acetaminophen/Caffeine Group	1

Intervention	Participants (Count of Participants)
Occipital Nerve Block	9
Oral Acetaminophen/Caffeine Group	4

Intervention	Participants (Count of Participants)
Occipital Nerve Block	7
Oral Acetaminophen/Caffeine Group	2

Intervention	Participants (Count of Participants)
Occipital Nerve Block	0
Oral Acetaminophen/Caffeine Group	2

Intervention	Participants (Count of Participants)
Occipital Nerve Block	0
Oral Acetaminophen/Caffeine Group	0

Intervention	Participants (Count of Participants)
Occipital Nerve Block	9
Oral Acetaminophen/Caffeine Group	14

Intervention	Participants (Count of Participants)
Occipital Nerve Block	4
Oral Acetaminophen/Caffeine Group	2

Emergency department for treatment of headache since treatment asked at 28 day follow up (NCT03951649)
Timeframe: 28 days

Number of Participants With Need for Second Line Treatment

Number of Participants With Response to Occipital Nerve Block in Pregnancy

Intervention	Participants (Count of Participants)
Occipital Nerve Block	5
Oral Acetaminophen/Caffeine Group	1

Intervention	Participants (Count of Participants)
Occipital Nerve Block	5
Oral Acetaminophen/Caffeine Group	5

Based on guidelines from the International Headache Society the primary outcome is the portion of women who experience resolution of headache or improvement of headache to mild range (VRS ≤ 3) at 2 hours following treatment with Occipital nerve block as compared to acetaminophen/caffeine cocktail. (NCT03951649)
Timeframe: 60-300 min

Response to Cross Over Treatment at 60 Min

Intervention	Participants (Count of Participants)
Occipital Nerve Block	20
Oral Acetaminophen/Caffeine Group	16

"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 60 min

Response to Second Line Treatment at 60 Min

Intervention	score on a scale (Median)
Occipital Nerve Block	6
Oral Acetaminophen/Caffeine Group	3

Response to Treatment Within 2 Hours

Intervention	score on a scale (Median)
Occipital Nerve Block	6
Oral Acetaminophen/Caffeine Group	4

Change From Baseline in Pain Intensity at Days 14-18

Intervention	score on a scale (Median)
Occipital Nerve Block	6.0
Oral Acetaminophen/Caffeine Group	6.5

"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale at Baseline and on Days 14 through 18. The average pain rating on Days 14 through 18 was calculated and used to determine the change from Baseline. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. A negative change score indicated improvement." (NCT00522041)
Timeframe: Baseline to Day 18

Percentage of Responders

Intervention	Units on a scale (Mean)
Cellegesic (Nitroglycerin 0.4%)	-40.4
Placebo	-34.9

"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale at Baseline and on Days 14 through 18. The average pain rating on Days 14 through 18 was calculated. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. A responder was defined as a participant with either a ≥ 50% decrease or a ≥ 10 mm decrease from Baseline in the 24 hour average pain intensity averaged over Days 14 to 18." (NCT00522041)
Timeframe: Baseline to Day 18

Time to an Improvement in Pain Intensity

Intervention	Percentage of responders (Number)
	≥ 50% decrease	≥ 10 mm decrease
Cellegisic (Nitroglycerin 0.4%)	72.4	88.6
Placebo	64.5	85.5

"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale (VAS) at Baseline and on each of the 21 treatment days of the study. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. Improvement was defined as either a ≥ 50% decrease or a ≥ 10 mm decrease from Baseline in rated pain intensity." (NCT00522041)
Timeframe: Baseline to Day 21

Article	Year
Caffeine in the management of patients with headache. The journal of headache and pain, 2017, Oct-24, Volume: 18, Issue:1 Topics: Abdominal Pain; Acetaminophen; Adult; Analgesics; Aspirin; Caffeine; Central Nervous System Stimulan	2017
[Headache in children and adolescents]. Ugeskrift for laeger, 2018, Feb-12, Volume: 180, Issue:7 Topics: Acetaminophen; Acute Pain; Adolescent; Analgesics, Non-Narcotic; Child; Diagnosis, Differential; Eme	2018
Caffeine as an analgesic adjuvant for acute pain in adults. The Cochrane database of systematic reviews, 2014, Dec-11, Issue:12 Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Aged; Analgesics; Caffeine; Chemotherapy, Adjuvant; Di	2014
Myth: Ibuprofen is superior to acetaminophen for the treatment of benign headaches in children and adults. CJEM, 2010, Volume: 12, Issue:3 Topics: Acetaminophen; Adolescent; Adult; Altitude Sickness; Analgesics, Non-Narcotic; Child; Headache; Huma	2010
Caffeine as an analgesic adjuvant for acute pain in adults. The Cochrane database of systematic reviews, 2012, Mar-14, Issue:3 Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Caffeine; Chemotherapy, Adjuvant; Female; Headache; Hu	2012
[Diagnosis and care of repeating headache in children]. Duodecim; laaketieteellinen aikakauskirja, 2005, Volume: 121, Issue:6 Topics: Acetaminophen; Age Factors; Child; Child, Preschool; Chronic Disease; Female; Finland; Headache; Hum	2005
[Acute and chronic headaches]. La Revue du praticien, 2006, Dec-15, Volume: 56, Issue:19 Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir	2006
Medication overuse headache. Minerva medica, 2007, Volume: 98, Issue:3 Topics: Acetaminophen; Adult; Analgesics; Drug Combinations; Female; Headache; Humans; Hydrocodone; Migraine	2007
[Treatment of idiopathic headache in childhood - recommendations of the German Migraine and Headache Society (DMKG)]. Schmerz (Berlin, Germany), 2002, Volume: 16, Issue:1 Topics: Acetaminophen; Adrenergic beta-Antagonists; Age Factors; Analgesics, Non-Narcotic; Biofeedback, Psyc	2002
"Nurse, my head hurts": a review of childhood headaches. The Journal of school nursing : the official publication of the National Association of School Nurses, 2001, Volume: 17, Issue:3 Topics: Acetaminophen; Adolescent; Age Factors; Analgesics, Non-Narcotic; Child; Child, Preschool; Emergenci	2001
[The latest in headache treatment]. Atencion primaria, 2002, May-31, Volume: 29, Issue:9 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Analgesics, Non-Narcotic; Angiotensin-Converting	2002
[Therapy of headache with analgesics]. Zeitschrift fur arztliche Fortbildung, 1991, Jan-25, Volume: 85, Issue:1-2 Topics: Acetaminophen; Analgesics; Aspirin; Headache; Humans; Ibuprofen; Pyrazoles; Pyrazolones	1991
[Carcinoma of the ureter after long-term use of analgesic [phenacetin derivative]--report of the two cases (spouses)]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 1990, Volume: 81, Issue:12 Topics: Acetaminophen; Aged; Carcinoma, Transitional Cell; Family; Female; Headache; Humans; Male; Time Fact	1990

Article	Year
Occipital Nerve Block Compared With Acetaminophen and Caffeine for Headache Treatment in Pregnancy: A Randomized Controlled Trial. Obstetrics and gynecology, 2023, Nov-01, Volume: 142, Issue:5 Topics: Acetaminophen; Anesthetics, Local; Caffeine; Female; Headache; Humans; Infant, Newborn; Nerve Block;	2023
Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial. BMJ open, 2019, 09-03, Volume: 9, Issue:8 Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug Combinations;	2019
Effects of preemptive intravenous paracetamol and ibuprofen on headache and myalgia in patients after electroconvulsive therapy: A placebo-controlled, double-blind, randomized clinical trial. Medicine, 2019, Volume: 98, Issue:51 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Depressive Disorder, Major; Double-Blind Method; Ele	2019
Randomized Trial of Adding Parenteral Acetaminophen to Prochlorperazine and Diphenhydramine to Treat Headache in the Emergency Department. The western journal of emergency medicine, 2017, Volume: 18, Issue:3 Topics: Acetaminophen; Administration, Intravenous; Adult; Analgesics; Diphenhydramine; Double-Blind Method;	2017
A randomized, double-blind, placebo-controlled trial on the role of preemptive analgesia with acetaminophen [paracetamol] in reducing headache following electroconvulsive therapy [ECT]. BMC psychiatry, 2017, 07-28, Volume: 17, Issue:1 Topics: Acetaminophen; Adolescent; Adult; Analgesia; Analgesics, Non-Narcotic; Double-Blind Method; Electroc	2017
Metoclopramide and Diphenhydramine: A Randomized Controlled Trial of a Treatment for Headache in Pregnancy when Acetaminophen Alone Is Ineffective (MAD Headache Study). American journal of perinatology, 2018, Volume: 35, Issue:13 Topics: Acetaminophen; Adult; Analgesics; Antiemetics; Codeine; Diphenhydramine; Double-Blind Method; Drug A	2018
Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study. BMC gastroenterology, 2013, Jul-01, Volume: 13 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Fissu	2013
Headache treatment after electroconvulsive treatment: a single-blinded trial comparator between eletriptan and paracetamol. The journal of ECT, 2015, Volume: 31, Issue:2 Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Electroconvulsive Therapy;	2015
Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials. BMC pharmacology & toxicology, 2015, Nov-27, Volume: 16 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Delayed-Action	2015
Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials. BMC pharmacology & toxicology, 2015, Nov-27, Volume: 16 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Delayed-Action	2015
Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials. BMC pharmacology & toxicology, 2015, Nov-27, Volume: 16 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Delayed-Action	2015
Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials. BMC pharmacology & toxicology, 2015, Nov-27, Volume: 16 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Delayed-Action	2015
Effects of preemptive analgesia in laparoscopic cholecystectomy: a double-blind randomized controlled trial. Surgical endoscopy, 2011, Volume: 25, Issue:1 Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cholecystectomy, Laparoscopic;	2011
Treatment with acetaminophen/paracetamol or ibuprofen alleviates post-dose symptoms related to intravenous infusion with zoledronic acid 5 mg. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012, Volume: 23, Issue:2 Topics: Acetaminophen; Aged; Arthralgia; Body Temperature; Bone Density Conservation Agents; Diphosphonates;	2012
Pain measurement: Visual Analogue Scale (VAS) and Verbal Rating Scale (VRS) in clinical trials with OTC analgesics in headache. Cephalalgia : an international journal of headache, 2012, Volume: 32, Issue:3 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Area Under Curve; Aspirin; Caffeine; Drug Combin	2012
Indications for and use of nonsteroidal antiinflammatory drugs and the risk of incident, symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial. American journal of epidemiology, 2012, Jul-15, Volume: 176, Issue:2 Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Cohort Studies; Co	2012
Adverse effects of superactivated charcoal administered to healthy volunteers. Hawaii medical journal, 2002, Volume: 61, Issue:11 Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Charcoal; Constipation; Drug Overdose; Femal	2002
Efficacy and safety of clemastine-pseudoephedrine-acetaminophen versus pseudoephedrine-acetaminophen in the treatment of seasonal allergic rhinitis in a 1-day, placebo-controlled park study. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 90, Issue:1 Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Bronchodilator Agents; California; Child	2003
High altitude headache: efficacy of acetaminophen vs. ibuprofen in a randomized, controlled trial. The Journal of emergency medicine, 2003, Volume: 24, Issue:4 Topics: Acetaminophen; Adult; Altitude Sickness; Analgesics, Opioid; Double-Blind Method; Female; Headache;	2003
Corticosteroids, ibuprofen, and acetaminophen for IFNbeta-1a flu symptoms in MS: a randomized trial. Neurology, 2004, Aug-10, Volume: 63, Issue:3 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asthenia; Chills; Double-Blind Method; Drug Administ	2004
Acetaminophen in the treatment of headaches associated with dipyridamole-aspirin combination. Neurology, 2004, Sep-28, Volume: 63, Issue:6 Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Aspirin; Dipyridamole; Drug Combinations; Female; Hea	2004
Oral multidose caffeine-paracetamol combination is not effective for the prophylaxis of postdural puncture headache. Journal of clinical anesthesia, 2005, Volume: 17, Issue:1 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anesthesia, Spinal; Caffeine; Central Nervous System	2005
Cryotherapy for treatment of ECT-induced headache. Journal of psychosocial nursing and mental health services, 2005, Volume: 43, Issue:4 Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics; California; Cross-Over Studies; Cryothera	2005
Effects of repeated-dose isradipine on the abuse liability of cocaine. Experimental and clinical psychopharmacology, 2005, Volume: 13, Issue:4 Topics: Acetaminophen; Administration, Oral; Adult; Analysis of Variance; Arrhythmias, Cardiac; Calcium Chan	2005
Comparison of 650 mg aspirin and 1,000 mg acetaminophen with each other, and with placebo in moderately severe headache. The American journal of medicine, 1983, Jun-14, Volume: 74, Issue:6A Topics: Acetaminophen; Adult; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Headache; Huma	1983
Caffeine as an analgesic adjuvant. JAMA, 1984, Apr-06, Volume: 251, Issue:13 Topics: Acetaminophen; Adjuvants, Pharmaceutic; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Dou	1984
Pretreatment regimens for adverse events related to infusion of amphotericin B. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 20, Issue:4 Topics: Acetaminophen; Adrenal Cortex Hormones; Amphotericin B; Diphenhydramine; Fever; Headache; Heparin; H	1995
Use of activated charcoal in a simulated poisoning with acetaminophen: a new loading dose for N-acetylcysteine? Annals of emergency medicine, 1993, Volume: 22, Issue:9 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adsorption; Adult; Biological Availability; Cha	1993
Ketoprofen, paracetamol and placebo in the treatment of episodic tension-type headache. Cephalalgia : an international journal of headache, 1996, Volume: 16, Issue:2 Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflamm	1996
[Effectiveness of Oleum menthae piperitae and paracetamol in therapy of headache of the tension type]. Der Nervenarzt, 1996, Volume: 67, Issue:8 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Drug Therapy, Combination; Fema	1996
Time to onset of analgesia and analgesic efficacy of effervescent acetaminophen 1000 mg compared to tablet acetaminophen 1000 mg in postoperative dental pain: a single-dose, double-blind, randomized, placebo-controlled study. Journal of clinical pharmacology, 2000, Volume: 40, Issue:4 Topics: Acetaminophen; Adolescent; Adult; Analgesia; Analgesics, Non-Narcotic; Double-Blind Method; Dry Sock	2000
Onset of analgesia for liquigel ibuprofen 400 mg, acetaminophen 1000 mg, ketoprofen 25 mg, and placebo in the treatment of postoperative dental pain. Journal of clinical pharmacology, 2001, Volume: 41, Issue:11 Topics: Abdominal Pain; Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory	2001
Both paracetamol and ibuprofen are equally effective in managing flu-like symptoms in relapsing-remitting multiple sclerosis patients during interferon beta-1a (AVONEX) therapy. Multiple sclerosis (Houndmills, Basingstoke, England), 2002, Volume: 8, Issue:1 Topics: Acetaminophen; Adult; Chills; Female; Fever; Headache; Humans; Ibuprofen; Interferon beta-1a; Interf	2002
A double-blind comparative evaluation of aspirin, paracetamol and paracetamol + caffeine (finimal) for their analgesic effectiveness. Archivum immunologiae et therapiae experimentalis, 1977, Volume: 25, Issue:2 Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Caffeine; Clinical Trials as Topic; Drug Therapy, C	1977
A controlled study of short-term treatment of tension headache. Current medical research and opinion, 1978, Volume: 5, Issue:9 Topics: Acetaminophen; Adult; Analgesics; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method;	1978
A single dose placebo-controlled study to assess the effectiveness of adding a muscle relaxant to a compound analgesic in the treatment of tension headache. The Journal of international medical research, 1979, Volume: 7, Issue:6 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Caffeine; Chlormezanone; Clinical Trials as Topi	1979
Study of a new analgesic compound in the treatment of tension headache. The Journal of international medical research, 1976, Volume: 4, Issue:1 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Caffeine; Clinical Trials as Topic; Dextropropox	1976
Analgesic/calmative effects of acetaminophen and phenyltoloxamine in treatment of simple nervous tension accompanied by headache. Current therapeutic research, clinical and experimental, 1976, Volume: 20, Issue:1 Topics: Acetaminophen; Adolescent; Adult; Aged; Anxiety; Benzhydryl Compounds; Clinical Trials as Topic; Dru	1976
Experimental tension headache in humans: a double blind comparison of the analgesic effect of dipyrone, naproxen plus paracetamol or placebo. Proceedings of the Western Pharmacology Society, 1992, Volume: 35 Topics: Acetaminophen; Adolescent; Adult; Dipyrone; Double-Blind Method; Drug Combinations; Female; Headache	1992
Headache pain model for assessing and comparing the efficacy of over-the-counter analgesic agents. Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:3 Topics: Acetaminophen; Adult; Analgesics; Aspirin; Caffeine; Double-Blind Method; Drug Combinations; Drug Ev	1991
The analgesic effects of caffeine in headache. Pain, 1991, Volume: 44, Issue:2 Topics: Acetaminophen; Adolescent; Adult; Affect; Caffeine; Double-Blind Method; Drug Combinations; Female;	1991
Evaluation of analgesic agents in recurring headache compared with other clinical pain models. Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:4 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Codeine; Data Interpretation, Statistical; Doubl	1990
Analgesic use and chronic renal disease. The New England journal of medicine, 1989, May-11, Volume: 320, Issue:19 Topics: Acetaminophen; Adult; Aged; Analgesics; Arthritis; Aspirin; Chronic Disease; Dose-Response Relations	1989
A comparison of naproxen sodium, acetaminophen and placebo in the treatment of muscle contraction headache. Headache, 1987, Volume: 27, Issue:7 Topics: Acetaminophen; Adult; Clinical Trials as Topic; Double-Blind Method; Female; Headache; Humans; Male;	1987
Symptomatic treatment of chronically recurring tension headache: a placebo-controlled, multicenter investigation of Fioricet and acetaminophen with codeine. Clinical therapeutics, 1987, Volume: 10, Issue:1 Topics: Acetaminophen; Adult; Barbiturates; Caffeine; Chronic Disease; Clinical Trials as Topic; Consumer Be	1987
Effect of small doses of aspirin and acetaminophen on total menstrual loss and pain of cramps and headache. Gynecologic and obstetric investigation, 1985, Volume: 19, Issue:1 Topics: Acetaminophen; Adolescent; Adult; Analysis of Variance; Aspirin; Clinical Trials as Topic; Double-Bl	1985
[EMA 3--a phenacetin-free combination with analgesic action]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1973, Jun-12, Volume: 62, Issue:24 Topics: Acetaminophen; Adult; Aged; Allyl Compounds; Analgesics; Barbiturates; Caffeine; Clinical Trials as	1973
Double-blind cross-over comparison of indomethacin, flurbiprofen, and placebo in ankylosing spondylitis. Annals of the rheumatic diseases, 1974, Volume: 33, Issue:2 Topics: Acetaminophen; Adult; Anti-Inflammatory Agents; Biphenyl Compounds; Blood Sedimentation; Clinical Tr	1974
Controlled and uncontrolled studies on "Fiorinal-PA" for symptomatic relief in tension headache. The Medical journal of Australia, 1970, Jul-25, Volume: 2, Issue:4 Topics: Acetaminophen; Aspirin; Barbiturates; Caffeine; Clinical Trials as Topic; Drug Synergism; Headache;	1970

Article	Year
Does immunosuppressive property of non-steroidal anti-inflammatory drugs (NSAIDs) reduce COVID-19 vaccine-induced systemic side effects? Drug discoveries & therapeutics, 2021, Nov-21, Volume: 15, Issue:5 Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; COVID-19 Vaccines; Fati	2021
Migraine abortive treatment in children and adolescents in Israel. Scientific reports, 2022, 05-06, Volume: 12, Issue:1 Topics: Acetaminophen; Adolescent; Child; Dipyrone; Female; Headache; Humans; Ibuprofen; Israel; Male; Migra	2022
Predictive models for determining treatment response to nonprescription acute medications in migraine: Results from the American Migraine Prevalence and Prevention Study. Headache, 2022, Volume: 62, Issue:6 Topics: Acetaminophen; Caffeine; Female; Headache; Humans; Male; Middle Aged; Migraine Disorders; Nonprescri	2022
Patterns of COVID-19-related headache: A cross-sectional study. Clinical neurology and neurosurgery, 2022, Volume: 219 Topics: Acetaminophen; COVID-19; Cross-Sectional Studies; Female; Headache; Humans; SARS-CoV-2	2022
Racial differences in treatment among patients with acute headache evaluated in the emergency department and discharged home. The American journal of emergency medicine, 2022, Volume: 60 Topics: Acetaminophen; Acute Pain; Analgesics; Emergency Service, Hospital; Headache; Healthcare Disparities	2022
Acute Headache Management for Patients with Subarachnoid Hemorrhage: An International Survey of Health Care Providers. Neurocritical care, 2023, Volume: 38, Issue:2 Topics: Acetaminophen; Analgesics, Opioid; Cross-Sectional Studies; Headache; Health Personnel; Humans; Suba	2023
Early analgesic administration and headache presence 7 days post-concussion in children. CJEM, 2022, Volume: 24, Issue:8 Topics: Acetaminophen; Adolescent; Analgesics; Brain Concussion; Canada; Child; Headache; Humans; Ibuprofen;	2022
2022 Taiwan Guidelines for Acute Treatment of Migraine. Acta neurologica Taiwanica, 2022, Jun-30, Volume: 31(2) Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Aspirin; Caffeine; Calcitonin G	2022
What is causing this patient's extreme exhaustion and headache? JAAPA : official journal of the American Academy of Physician Assistants, 2020, Volume: 33, Issue:3 Topics: Acetaminophen; Adult; Ampicillin; Anti-Bacterial Agents; Azithromycin; Cefpodoxime; Ceftizoxime; Cef	2020
Paracetamol alters empathy scores in healthy and headache subjects: Functional MRI correlates. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2020, Volume: 78 Topics: Acetaminophen; Adult; Brain; Empathy; Female; Headache; Humans; Magnetic Resonance Imaging; Male; Mi	2020
Just the Facts: Hypertension in the emergency department. CJEM, 2020, Volume: 22, Issue:4 Topics: Acetaminophen; Aged; Emergency Service, Hospital; Female; Headache; Humans; Hypertension; Pharmacist	2020
Diagnosis and Treatment of Headache in a Pediatric Emergency Department. Pediatric emergency care, 2020, Volume: 36, Issue:12 Topics: Acetaminophen; Adolescent; Child; Emergency Service, Hospital; Female; Headache; Humans; Male; Migra	2020
Increased risk of preeclampsia after use of paracetamol during pregnancy - causal or coincidence? BMC pregnancy and childbirth, 2021, Jan-06, Volume: 21, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Causality; Cohort Studies; Female; Gestational Age; Headach	2021
Diagnosis of Agglomeration and Crystallinity of Active Pharmaceutical Ingredients in Over the Counter Headache Medication by Electrospray Laser Desorption Ionization Mass Spectrometry Imaging. Molecules (Basel, Switzerland), 2021, Jan-25, Volume: 26, Issue:3 Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Caffeine; Headache; Lasers; Nonprescription Drugs;	2021
Around Manaslu Ultramarathon: Diarrhea Is Still the King. Wilderness & environmental medicine, 2017, Volume: 28, Issue:4 Topics: Acetaminophen; Acetazolamide; Altitude; Altitude Sickness; Analgesics, Non-Narcotic; Anti-Bacterial	2017
Prevalence and clinical characteristics of headaches among undergraduate students in three tertiary institutions in Ilorin, Nigeria. Nigerian journal of clinical practice, 2017, Volume: 20, Issue:11 Topics: Acetaminophen; Adolescent; Adult; Chronic Disease; Cross-Sectional Studies; Female; Headache; Humans	2017
Alzheimer disease triggered by reversible posterior leukoencephalopathy syndrome. Neurologia, 2020, Volume: 35, Issue:4 Topics: Acetaminophen; Aged; Alzheimer Disease; Analgesics, Non-Narcotic; Antihypertensive Agents; Captopril	2020
Reproductive Headache? Investigating Acetaminophen as a Potential Endocrine Disruptor. Environmental health perspectives, 2018, 03-09, Volume: 126, Issue:3 Topics: Acetaminophen; Animals; Endocrine Disruptors; Female; Headache; Humans; Male; Pregnancy; Reproductio	2018
Cerebral Venous Thrombosis: An Uncommon Cause of Papilledema on Bedside Ocular Ultrasound. The Journal of emergency medicine, 2019, Volume: 56, Issue:3 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anesthetics, Local; Cerebral Veins; Computed Tomogra	2019
Treating Therapy-Resistant Headache After Aneurysmal Subarachnoid Hemorrhage with Acupuncture. Neurocritical care, 2019, Volume: 31, Issue:2 Topics: Acetaminophen; Acupuncture Therapy; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Dipy	2019
Paracetamol-induced Stevens Johnson syndrome and cholestatic hepatitis. Current drug safety, 2015, Volume: 10, Issue:2 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Eruptio	2015
Utilization of over the counter medication among pregnant women; a cross-sectional study conducted at Isra University Hospital, Hyderabad. JPMA. The Journal of the Pakistan Medical Association, 2016, Volume: 66, Issue:1 Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal;	2016
Headaches attributed to airplane travel: a Danish survey. The journal of headache and pain, 2016, Volume: 17 Topics: Acetaminophen; Adult; Aged; Air Travel; Analgesics; Denmark; Female; Headache; Health Surveys; Human	2016
CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships. PloS one, 2016, Volume: 11, Issue:6 Topics: Acetaminophen; Adult; Age of Onset; Aged; Aged, 80 and over; Analgesics; CADASIL; Codeine; Cross-Sec	2016
The Headache of Acetaminophen Overdose: Getting the NAC. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2017, Volume: 15, Issue:4 Topics: Acetaminophen; Drug Overdose; Headache; Humans; Immunoassay; Liver	2017
A pilot study examining the effects of priming headache illness schema on attentional engagement towards pain relief medication, in those with high and low medication treatment beliefs. Psychology, health & medicine, 2017, Volume: 22, Issue:7 Topics: Acetaminophen; Adaptation, Psychological; Adult; Analgesics, Non-Narcotic; Attention; Female; Headac	2017
Analysis of headache management in a busy emergency room in the United States. Headache, 2008, Volume: 48, Issue:6 Topics: Academic Medical Centers; Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inf	2008
Headache in children. Journal of the South Carolina Medical Association (1975), 2008, Volume: 104, Issue:6 Topics: Acetaminophen; Adolescent; Age Factors; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child;	2008
Obstructive sleep apnoea and acetaminophen safety - is the liver at risk? Experimental physiology, 2009, Volume: 94, Issue:2 Topics: Acetaminophen; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and	2009
Fixed drug eruption induced by phenylephrine: a case of polysensitivity. Journal of investigational allergology & clinical immunology, 2009, Volume: 19, Issue:4 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Bronchial Provocation Tests; Common Cold; Cross Reac	2009
N-acetylcysteine-induced headache in hospitalized patients with acute acetaminophen overdose. Fundamental & clinical pharmacology, 2011, Volume: 25, Issue:3 Topics: Acetaminophen; Acetylcysteine; Antidotes; Cohort Studies; Drug Overdose; Female; Headache; Hospitali	2011
[Update on current care guidelines; childhood headache]. Duodecim; laaketieteellinen aikakauskirja, 2010, Volume: 126, Issue:14 Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Headache; Humans; Ibuprofen; Propranolol	2010
[Self-medication of regular headache: a community pharmacy-based survey in Belgium]. Journal de pharmacie de Belgique, 2012, Issue:2 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster	2012
Using the simulated patient methodology to assess paracetamol-related counselling for headache. PloS one, 2012, Volume: 7, Issue:12 Topics: Acetaminophen; Counseling; Female; Headache; Humans; Male; Pharmacies; Quality Control	2012
Benign exertional headache. Annals of emergency medicine, 2003, Volume: 41, Issue:1 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Emergencies; Exercise; Headache;	2003
Idiopathic stabbing headache: clinical characteristics of children and adolescents. Brain & development, 2003, Volume: 25, Issue:4 Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Diagnosis, Differential; Electroencephal	2003
Caffeine consumption in drivers of heavy vehicles in Turkey. Public health, 2003, Volume: 117, Issue:5 Topics: Accidents, Traffic; Acetaminophen; Adult; Caffeine; Cross-Sectional Studies; Headache; Humans; Middl	2003
Controlled studies of chlorzoxazone and chlorzoxazone plus acetaminophen in the treatment of myalgia associated with headache. Southern medical journal, 1960, Volume: 63 Topics: Acetaminophen; Acetanilides; Chlorzoxazone; Disease; Headache; Humans; Muscles; Muscular Diseases; M	1960
Acetaminophen preferable to ibuprofen for pretreatment of electroconvulsive therapy-induced headache. The Journal of clinical psychiatry, 2004, Volume: 65, Issue:5 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Electroconvulsive	2004
Acute onset of bilateral myoclonus in a 16-year-old female. Journal of the Mississippi State Medical Association, 2004, Volume: 45, Issue:6 Topics: Acetaminophen; Acute Disease; Adolescent; Aspirin; Attention Deficit Disorder with Hyperactivity; Ca	2004
[Update on current care guidelines. Headache among children]. Duodecim; laaketieteellinen aikakauskirja, 2005, Volume: 121, Issue:4 Topics: Acetaminophen; Analgesics; Child; Child, Preschool; Cohort Studies; Female; Finland; Follow-Up Studi	2005
Churg-Strauss syndrome associated with hypersensitivity to acetaminophen. Internal medicine (Tokyo, Japan), 2005, Volume: 44, Issue:5 Topics: Acetaminophen; Analgesics, Non-Narcotic; Arteries; Biopsy; Chronic Disease; Churg-Strauss Syndrome;	2005
Use and misuse of aspirin in rural Ethiopia. East African medical journal, 2006, Volume: 83, Issue:1 Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Child; Cross-Sectional Studies; Ethiopia; Female; F	2006
Acetylsalicylic acid, paracetamol and caffeine combination in headache. Cephalalgia : an international journal of headache, 2006, Volume: 26, Issue:10 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine;	2006
[Chronic interstitial nephritis in an 18-year-old due to intake of a compound analgesic]. Medizinische Klinik (Munich, Germany : 1983), 2006, Oct-15, Volume: 101, Issue:10 Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biopsy; Caffeine; Creat	2006
The fixed combination of acetylsalicylic acid, paracetamol and caffeine. Cephalalgia : an international journal of headache, 2006, Volume: 26, Issue:12 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine;	2006
Analgesic nephropathy. Kidney international, 2007, Volume: 72, Issue:4 Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Aspirin; Drug Combinations; Headache; Humans; Kidney	2007
Hyperostosis frontalis interna in a patient with giant cell arteritis. Modern rheumatology, 2008, Volume: 18, Issue:2 Topics: Acetaminophen; Analgesics, Non-Narcotic; Calcinosis; Female; Giant Cell Arteritis; Glucocorticoids;	2008
Hemorrhagic diathesis caused by drinking an herbal tea. JAMA, 1983, May-20, Volume: 249, Issue:19 Topics: Acetaminophen; Adult; Back Pain; Beverages; Dextropropoxyphene; Drug Synergism; Female; Headache; He	1983
Do aspirin and acetaminophen affect total menstrual loss? Gynecologic and obstetric investigation, 1984, Volume: 18, Issue:3 Topics: Acetaminophen; Adolescent; Adult; Analgesics; Aspirin; Double-Blind Method; Dysmenorrhea; Female; He	1984
A plain man's guide to the management of migraine. British medical journal (Clinical research ed.), 1982, Apr-10, Volume: 284, Issue:6322 Topics: Acetaminophen; Aspirin; Ergotamine; Headache; Humans; Metoclopramide; Migraine Disorders; Sleep	1982
Acetaminophen and aspirin. Prescription, use, and accidental ingestion among children. American journal of diseases of children (1960), 1982, Volume: 136, Issue:11 Topics: Acetaminophen; Adolescent; Aspirin; Child; Child, Preschool; Drug Prescriptions; Drug Utilization; F	1982
Analgesic use and colorectal cancer. Preventive medicine, 1995, Volume: 24, Issue:2 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Case-Control Studies; Colorectal	1995
[Headache caused by analgesics]. Nederlands tijdschrift voor geneeskunde, 1994, Dec-24, Volume: 138, Issue:52 Topics: Acetaminophen; Adult; Female; Headache; Humans; Middle Aged; Migraine Disorders; Sumatriptan	1994
[Does hyperthyroidism promote drug hepatotoxicity]. Polskie Archiwum Medycyny Wewnetrznej, 1994, Volume: 92, Issue:4 Topics: Acetaminophen; Adolescent; Aged; Estrogens; Female; Genital Diseases, Female; Headache; Humans; Hype	1994
Do thyroid hormones promote hepatotoxicity to acetaminophen? The American journal of gastroenterology, 1994, Volume: 89, Issue:8 Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Female; Goiter; Headache; Humans;	1994
Over-the-counter analgesics and kidney disease. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1996, Volume: 27, Issue:6 Topics: Acetaminophen; Analgesics; Aspirin; Drug Combinations; Headache; Humans; Kidney Diseases; Nonprescri	1996
Restless legs syndrome. Archives of internal medicine, 1996, Nov-11, Volume: 156, Issue:20 Topics: Acetaminophen; Analgesics, Non-Narcotic; Headache; Humans; Restless Legs Syndrome	1996
Serotonin and analgesic-related headache. Cephalalgia : an international journal of headache, 1996, Volume: 16, Issue:6 Topics: Acetaminophen; Analgesics; Blood Platelets; Codeine; Headache; Humans; Migraine Disorders; Receptors	1996
[Clinical features of daily chronic headache]. Revista de neurologia, 1997, Volume: 25, Issue:143 Topics: Acetaminophen; Adult; Age of Onset; Analgesics; Benzodiazepines; Caffeine; Chronic Disease; Ergotami	1997
[Pancreatic pain in cholecystectomized patients after taking paracetamol and codeine]. Atencion primaria, 1997, Nov-30, Volume: 20, Issue:9 Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Cholecystectomy; Codeine; Headache; Hum	1997
Twelve cases of analgesic headache. Archives of disease in childhood, 1998, Volume: 78, Issue:6 Topics: Acetaminophen; Adolescent; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child; Codeine; Drug	1998
Treatment for postdural puncture headache associated with late postpartum eclampsia. Acta anaesthesiologica Belgica, 1999, Volume: 50, Issue:2 Topics: Acetaminophen; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Benzoat	1999
Delayed-type hypersensitivity rash from paracetamol. Contact dermatitis, 2000, Volume: 43, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Diagnosis, Differential; Drug Hypersensitivity; Female; Hea	2000
Pharmacotherapeutics in space. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology, 1999, Volume: 6, Issue:1 Topics: Acetaminophen; Aerospace Medicine; Analgesics, Non-Narcotic; Headache; Histamine H1 Antagonists; Hum	1999
[Treatment of post-dural-puncture headache with intravenous cortisone]. Revista espanola de anestesiologia y reanimacion, 2002, Volume: 49, Issue:2 Topics: Acetaminophen; Adult; Analgesics; Anesthesia, Epidural; Anesthesia, Obstetrical; Anti-Inflammatory A	2002
Post-operative headache--a multifactorial analysis. European journal of anaesthesiology, 1991, Volume: 8, Issue:1 Topics: Acetaminophen; Anesthesia, Inhalation; Anesthesia, Intravenous; Enflurane; Female; Halothane; Headac	1991
Drug abuse and headache. The Medical clinics of North America, 1991, Volume: 75, Issue:3 Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Ergot Alkaloi	1991
Acute renal failure in an alcoholic during therapeutic acetaminophen ingestion. Southern medical journal, 1988, Volume: 81, Issue:9 Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcoholism; Headache; Humans; Kidney Tubular Necrosis, Ac	1988
Preserving the character of Vermont for the good of the citizenry. Journal of substance abuse treatment, 1985, Volume: 2, Issue:1 Topics: Acetaminophen; Adult; Dextropropoxyphene; Drug Combinations; Headache; Humans; Legislation, Drug; Ma	1985
Pain in haemophilia. Lancet (London, England), 1973, May-05, Volume: 1, Issue:7810 Topics: Acetaminophen; Analgesics; Aspirin; Codeine; Cryotherapy; Gastrointestinal Hemorrhage; Headache; Hem	1973
[Clinical observations and analgesic properties of the association of paracetamol and phenylbutazone]. Revista brasileira de medicina, 1966, Volume: 23, Issue:9 Topics: Acetaminophen; Back Pain; Contusions; Ear Diseases; Headache; Humans; Joint Diseases; Muscular Disea	1966
[Clinical study of a new antalgic: Propofan]. Lyon medical, 1972, Jan-23, Volume: 227, Issue:2 Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Caffeine; Dextropropoxyphene; Female; Headache; His	1972
Q fever. British medical journal, 1973, Apr-07, Volume: 2, Issue:5857 Topics: Acetaminophen; Animals; Aspirin; Cattle; Coxiella; Disease Reservoirs; Feces; Fever; Headache; Human	1973
Analgesic nephropathy associated with paracetamol. Proceedings of the Royal Society of Medicine, 1973, Volume: 66, Issue:9 Topics: Acetaminophen; Codeine; Female; Headache; Humans; Kidney Diseases; Middle Aged; Nausea; Phenacetin;	1973
Headache. The British journal of clinical practice, 1972, Volume: 26, Issue:8 Topics: Acetaminophen; Anti-Bacterial Agents; Chlordiazepoxide; Headache; Humans; Migraine Disorders; Sinusi	1972
[Treatment of vascular headaches with a new compound preparation]. Zeitschrift fur Allgemeinmedizin, 1970, Feb-28, Volume: 46, Issue:6 Topics: Acetaminophen; Adult; Amobarbital; Analgesics; Caffeine; Codeine; Ergotamine; Female; Headache; Huma	1970
[Use and misuse of light analgetics for headache]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1971, Mar-10, Volume: 91, Issue:7 Topics: Acetaminophen; Antipyrine; Aspirin; Dextropropoxyphene; Headache; Humans; Phenacetin; Salicylamides;	1971

acetaminophen and Bilateral Headache