acetaminophen has been researched along with Bacterial Meningitides in 8 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute bacterial meningitis is a bacterial infection of the membranes that surround and protect the brain, known as the meninges." | 2.72 | Non-corticosteroid adjuvant therapies for acute bacterial meningitis. ( Bentzer, P; Calevo, MG; Fisher, J; Linder, A, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fisher, J | 1 |
| Linder, A | 1 |
| Calevo, MG | 1 |
| Bentzer, P | 1 |
| Savonius, O | 1 |
| Rugemalira, E | 1 |
| Roine, I | 2 |
| Cruzeiro, ML | 2 |
| Peltola, H | 3 |
| Pelkonen, T | 2 |
| Molyneux, EM | 1 |
| Kawaza, K | 1 |
| Phiri, A | 1 |
| Chimalizeni, Y | 1 |
| Mankhambo, L | 1 |
| Schwalbe, E | 1 |
| Kataja, M | 2 |
| Pensulo, P | 1 |
| Chilton, L | 1 |
| Thwaites, GE | 1 |
| Pitkäranta, A | 1 |
| Bharti, B | 1 |
| Bharti, S | 1 |
| Bonadio, WA | 1 |
| Bellomo, T | 1 |
| Brady, W | 1 |
| Smith, D | 1 |
| Casas Gómez, J | 1 |
| García Jiménez, JL | 1 |
| Rota Zapata, L | 1 |
| Rodríguez Martín, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis, Especially of Pneumococcal Meningitis, in Angola.[NCT01540838] | Phase 4 | 375 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Hearing thresholds (in decibel, dB) were determined by brainstem evoked response audiometry (BERA), for each ear separately. The better ear's hearing threshold, obtained on admission or shortly thereafter, was compared with the better ear's hearing threshold obtained at earliest after one week of treatment. (NCT01540838)
Timeframe: Hearing thresholds obtained during any of the first three days after hospital admission were compared with hearing thresholds obtained on day seven or later, during the hospital stay. The longest hospital stay was 84 days.
| Intervention | dB (Median) |
|---|---|
| Infusion With Paracetamol | 0 |
| Bolus With Placebo | 0 |
All patients who had received at least one dose of treatment and died during the hospital stay. (NCT01540838)
Timeframe: The outcome was assessed each day until the patient was discharged from the hospital. The longest hospital stay was 84 days, while the last death occurred 39 days after treatment initiation.
| Intervention | Participants (Count of Participants) |
|---|---|
| Infusion With Paracetamol | 71 |
| Bolus With Placebo | 75 |
All patients who had received at least one dose of treatment and were dead on day 7 from the institution of treatment on day 1. (NCT01540838)
Timeframe: On day 7 from the institution of treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| Infusion With Paracetamol | 61 |
| Bolus With Placebo | 64 |
Defined as death or any severe neurological sequelae, or hemi- or monoparesis, or ataxia, or psychomotor retardation of any degree. (NCT01540838)
Timeframe: Examined at discharge from hospital. The longest hospital stay was 84 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| Infusion With Paracetamol | 104 |
| Bolus With Placebo | 89 |
Defined as death or any severe neurological sequelae, or hemi- or monoparesis, or ataxia, or psychomotor retardation of any degree. (NCT01540838)
Timeframe: Examined on day 7 since institution of treatment.
| Intervention | Participants (Count of Participants) |
|---|---|
| Infusion With Paracetamol | 96 |
| Bolus With Placebo | 86 |
Death or severe neurological sequelae, defined as blindness, tetraplegia/paresis, hydrocephalus requiring a shunt and severe psychomotor retardation (NCT01540838)
Timeframe: Examined at discharge from hospital. The longest hospital stay was 84 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| Infusion With Paracetamol | 90 |
| Bolus With Placebo | 85 |
Death or severe neurological sequelae, defined as blindness, tetraplegia/paresis, hydrocephalus requiring a shunt and severe psychomotor retardation (NCT01540838)
Timeframe: Examined on day 7 since institution of treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| Infusion With Paracetamol | 80 |
| Bolus With Placebo | 75 |
Hearing thresholds (in decibel, dB) were determined by brainstem evoked response audiometry (BERA), for each ear separately. Deafness was defined as a hearing threshold >80 dB in the better ear. (NCT01540838)
Timeframe: This outcome includes hearing thresholds determined at earliest seven days after the institution of treatment, during the hospital stay. The longest hospital stay was 84 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| Infusion With Paracetamol | 3 |
| Bolus With Placebo | 1 |
"Scores on the modified Glasgow Outcome Scale which range from a maximum of 5 (best) to a minimum of 1 (worst) points.~The Glasgow Outcome Scale categorizes the outcome after brain injury into five categories, based on the level and severeness of disability. As hearing impairment is one of the most common sequelae of bacterial meningitis, an assessment of hearing should be included when estimating the grade of disability.~Hearing thresholds (in decibel, dB) were determined by brainstem evoked response audiometry (BERA), for each ear separately." (NCT01540838)
Timeframe: Examined at discharge from hospital, except for hearing evaluations which were performed at earliest seven days since the institution of treatment, during the hospital stay. The longest hospital stay was 84 days.
| Intervention | score on a scale (Median) |
|---|---|
| Infusion With Paracetamol | 5 |
| Bolus With Placebo | 5 |
1 review available for acetaminophen and Bacterial Meningitides
| Article | Year |
|---|---|
Non-corticosteroid adjuvant therapies for acute bacterial meningitis.
Topics: Acetaminophen; Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Child; Hearing Loss; Humans; M | 2021 |
3 trials available for acetaminophen and Bacterial Meningitides
| Article | Year |
|---|---|
Extended Continuous β-Lactam Infusion With Oral Acetaminophen in Childhood Bacterial Meningitis: A Randomized, Double-blind Clinical Trial.
Topics: Acetaminophen; beta-Lactams; Child; Double-Blind Method; Drug Therapy, Combination; Humans; Meningit | 2021 |
Glycerol and acetaminophen as adjuvant therapy did not affect the outcome of bacterial meningitis in Malawian children.
Topics: Acetaminophen; Anti-Bacterial Agents; Ceftriaxone; Double-Blind Method; Drug Therapy, Combination; G | 2014 |
Slow initial β-lactam infusion and oral paracetamol to treat childhood bacterial meningitis: a randomised, controlled trial.
Topics: Acetaminophen; Adolescent; Angola; Anti-Infective Agents; Antipyretics; Cefotaxime; Child; Child, Pr | 2011 |
4 other studies available for acetaminophen and Bacterial Meningitides
| Article | Year |
|---|---|
Bacterial meningitis: frapper fort ou frapper doucement?
Topics: Acetaminophen; Anti-Infective Agents; Antipyretics; Cefotaxime; Female; Gram-Positive Bacteria; Huma | 2011 |
Antibiotics by bolus or infusion for bacterial meningitis?
Topics: Acetaminophen; Anti-Infective Agents; Antipyretics; Cefotaxime; Female; Gram-Positive Bacteria; Huma | 2012 |
Correlating changes in body temperature with infectious outcome in febrile children who receive acetaminophen.
Topics: Acetaminophen; Administration, Oral; Age Factors; Bacteremia; Body Temperature; Child, Preschool; Fe | 1993 |
[Neuro-tuberculosis: solitary supratentorial tuberculoma and meningitis in a 5-year-old child].
Topics: Acetaminophen; Amoxicillin; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Child, Preschool; Clavu | 1998 |