acetaminophen has been researched along with Autism Spectrum Disorder in 13 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Autism Spectrum Disorder: Wide continuum of associated cognitive and neurobehavioral disorders, including, but not limited to, three core-defining features: impairments in socialization, impairments in verbal and nonverbal communication, and restricted and repetitive patterns of behaviors. (from DSM-V)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen (paracetamol) is available over the counter in most countries and is widely considered to be safe for use during pregnancy; studies report gestational exposures to acetaminophen that lie in the 46%-65% range." | 8.93 | Use of acetaminophen (paracetamol) during pregnancy and the risk of autism spectrum disorder in the offspring. ( Andrade, C, 2016) |
| "Prior studies have raised concern about maternal acetaminophen use during pregnancy and increased risk of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in their children; however, most studies have relied on maternal self-report." | 7.96 | Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood. ( Azuine, RE; Hong, X; Hou, W; Ji, Y; Pearson, C; Riley, A; Wang, G; Wang, X; Zhang, Y; Zuckerman, B, 2020) |
| "Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy." | 7.83 | Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study. ( Liew, Z; Olsen, J; Ritz, B; Virk, J, 2016) |
| "Acetaminophen is extensively used during pregnancy." | 7.83 | Acetaminophen use in pregnancy and neurodevelopment: attention function and autism spectrum symptoms. ( Andiarena, A; Avella-Garcia, CB; Fortuny, J; Galán, IR; García-Esteban, R; Iñiguez, C; Julvez, J; Rebordosa, C; Rodríguez-Bernal, CL; Santa-Marina, L; Sunyer, J; Tardón, A, 2016) |
| "Acetaminophen use has been reported to be associated with an increased risk of ASD." | 6.72 | Endocannabinoid System Dysregulation from Acetaminophen Use May Lead to Autism Spectrum Disorder: Could Cannabinoid Treatment Be Efficacious? ( Antonucci, N; Brigida, AL; Gould, GG; Schultz, S; Siniscalco, D, 2021) |
| "Paracetamol (acetaminophen) use during pregnancy and early childhood was accepted as safe in the 1970s, but is now a subject of considerable concern." | 5.22 | The safety of pediatric use of paracetamol (acetaminophen): a narrative review of direct and indirect evidence. ( Anderson, LG; Bono-Lunn, D; Cendejas Hernandez, J; Jones Iii, JP; Konsoula, Z; Kuchibhatla, M; Lawton, VG; Palkar, A; Parker, W; Patel, E; Reissner, KJ; Sarafian, JT, 2022) |
| "The non-prescription medication paracetamol (acetaminophen, APAP) is currently recommended as a safe pain and fever treatment during pregnancy." | 4.98 | Prenatal paracetamol exposure and child neurodevelopment: A review. ( Bauer, AZ; Bornehag, CG; Herbert, MR; Kriebel, D; Swan, SH, 2018) |
| "Acetaminophen is the analgesic and antipyretic most commonly used during pregnancy." | 4.98 | Prenatal Exposure to Acetaminophen and Risk for Attention Deficit Hyperactivity Disorder and Autistic Spectrum Disorder: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis of Cohort Studies. ( Gorelik, E; Levine, H; Masarwa, R; Matok, I; Perlman, A; Reif, S, 2018) |
| "Acetaminophen (paracetamol) is available over the counter in most countries and is widely considered to be safe for use during pregnancy; studies report gestational exposures to acetaminophen that lie in the 46%-65% range." | 4.93 | Use of acetaminophen (paracetamol) during pregnancy and the risk of autism spectrum disorder in the offspring. ( Andrade, C, 2016) |
| " 2018;187(8):1817-1827) conducted a meta-analysis of the association between in utero acetaminophen exposure and risks of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD)." | 3.96 | Invited Commentary: The Disillusionment of Developmental Origins of Health and Disease (DOHaD) Epidemiology. ( Gilman, SE; Hornig, M, 2020) |
| "Prior studies have raised concern about maternal acetaminophen use during pregnancy and increased risk of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in their children; however, most studies have relied on maternal self-report." | 3.96 | Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood. ( Azuine, RE; Hong, X; Hou, W; Ji, Y; Pearson, C; Riley, A; Wang, G; Wang, X; Zhang, Y; Zuckerman, B, 2020) |
| "Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy." | 3.83 | Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study. ( Liew, Z; Olsen, J; Ritz, B; Virk, J, 2016) |
| "Acetaminophen is extensively used during pregnancy." | 3.83 | Acetaminophen use in pregnancy and neurodevelopment: attention function and autism spectrum symptoms. ( Andiarena, A; Avella-Garcia, CB; Fortuny, J; Galán, IR; García-Esteban, R; Iñiguez, C; Julvez, J; Rebordosa, C; Rodríguez-Bernal, CL; Santa-Marina, L; Sunyer, J; Tardón, A, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 8 (61.54) | 2.80 |
| Authors | Studies |
|---|---|
| Bührer, C | 1 |
| Endesfelder, S | 1 |
| Scheuer, T | 1 |
| Schmitz, T | 1 |
| Patel, E | 1 |
| Jones Iii, JP | 1 |
| Bono-Lunn, D | 1 |
| Kuchibhatla, M | 1 |
| Palkar, A | 1 |
| Cendejas Hernandez, J | 1 |
| Sarafian, JT | 1 |
| Lawton, VG | 1 |
| Anderson, LG | 1 |
| Konsoula, Z | 1 |
| Reissner, KJ | 1 |
| Parker, W | 1 |
| Baker, BH | 1 |
| Rafikian, EE | 1 |
| Hamblin, PB | 1 |
| Strait, MD | 1 |
| Yang, M | 1 |
| Pearson, BL | 1 |
| Zehra, A | 1 |
| Altaf, H | 1 |
| Gilman, SE | 1 |
| Hornig, M | 1 |
| Ji, Y | 1 |
| Azuine, RE | 1 |
| Zhang, Y | 1 |
| Hou, W | 1 |
| Hong, X | 1 |
| Wang, G | 1 |
| Riley, A | 1 |
| Pearson, C | 1 |
| Zuckerman, B | 1 |
| Wang, X | 1 |
| Schultz, S | 1 |
| Gould, GG | 1 |
| Antonucci, N | 1 |
| Brigida, AL | 1 |
| Siniscalco, D | 1 |
| Alemany, S | 1 |
| Avella-García, C | 1 |
| Liew, Z | 2 |
| García-Esteban, R | 2 |
| Inoue, K | 1 |
| Cadman, T | 1 |
| López-Vicente, M | 1 |
| González, L | 1 |
| Riaño Galán, I | 1 |
| Andiarena, A | 2 |
| Casas, M | 1 |
| Margetaki, K | 1 |
| Strandberg-Larsen, K | 1 |
| Lawlor, DA | 1 |
| El Marroun, H | 1 |
| Tiemeier, H | 1 |
| Iñiguez, C | 2 |
| Tardón, A | 2 |
| Santa-Marina, L | 2 |
| Júlvez, J | 2 |
| Porta, D | 1 |
| Chatzi, L | 1 |
| Sunyer, J | 2 |
| Bauer, AZ | 1 |
| Kriebel, D | 1 |
| Herbert, MR | 1 |
| Bornehag, CG | 1 |
| Swan, SH | 1 |
| Masarwa, R | 1 |
| Levine, H | 1 |
| Gorelik, E | 1 |
| Reif, S | 1 |
| Perlman, A | 1 |
| Matok, I | 1 |
| Ritz, B | 1 |
| Virk, J | 1 |
| Olsen, J | 1 |
| Andrade, C | 1 |
| Avella-Garcia, CB | 1 |
| Fortuny, J | 1 |
| Rebordosa, C | 1 |
| Galán, IR | 1 |
| Rodríguez-Bernal, CL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Long Term Follow-up of the TREOCAPA (Prophylactic TREatment Of the duCtus Arteriosus in Preterm Infants by Acetaminophen) Study (TREOCAPA-LT)[NCT06064825] | 500 participants (Anticipated) | Observational | 2023-11-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for acetaminophen and Autism Spectrum Disorder
| Article | Year |
|---|---|
Paracetamol (Acetaminophen) and the Developing Brain.
Topics: Acetaminophen; Adult; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Auti | 2021 |
The safety of pediatric use of paracetamol (acetaminophen): a narrative review of direct and indirect evidence.
Topics: Acetaminophen; Animals; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Chi | 2022 |
Endocannabinoid System Dysregulation from Acetaminophen Use May Lead to Autism Spectrum Disorder: Could Cannabinoid Treatment Be Efficacious?
Topics: Acetaminophen; Autism Spectrum Disorder; Cannabinoids; Endocannabinoids; Humans; Receptor, Cannabino | 2021 |
Prenatal paracetamol exposure and child neurodevelopment: A review.
Topics: Acetaminophen; Attention; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; C | 2018 |
Prenatal Exposure to Acetaminophen and Risk for Attention Deficit Hyperactivity Disorder and Autistic Spectrum Disorder: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis of Cohort Studies.
Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Female; Huma | 2018 |
Use of acetaminophen (paracetamol) during pregnancy and the risk of autism spectrum disorder in the offspring.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Autism Spectrum Disorder; Female; Humans; Pregnancy; Prenat | 2016 |
7 other studies available for acetaminophen and Autism Spectrum Disorder
| Article | Year |
|---|---|
Sex-specific neurobehavioral and prefrontal cortex gene expression alterations following developmental acetaminophen exposure in mice.
Topics: Acetaminophen; Adult; Animals; Autism Spectrum Disorder; Female; Gene Expression; Gene Expression Re | 2023 |
Autism spectrum disorder related to unwarranted paracetamol use in pregnancy.
Topics: Acetaminophen; Autism Spectrum Disorder; Female; Humans; Pregnancy; Prenatal Exposure Delayed Effect | 2022 |
Invited Commentary: The Disillusionment of Developmental Origins of Health and Disease (DOHaD) Epidemiology.
Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Autistic Dis | 2020 |
Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood.
Topics: Acetaminophen; Adult; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Bioma | 2020 |
Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Attention; Attention Deficit Disorder with Hyperacti | 2021 |
Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study.
Topics: Acetaminophen; Adult; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Child | 2016 |
Acetaminophen use in pregnancy and neurodevelopment: attention function and autism spectrum symptoms.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Attention; Autism Spectrum Disorder; Child Developme | 2016 |