acetaminophen has been researched along with Aura in 15 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Secondary outcome measures are postoperative pain intensity scores, psychological parameters, length of hospital stay and adverse events and will be reassessed at 3 and 6 months after surgery, with a baseline measurement preoperatively." | 6.90 | Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial. ( Bastiaenen, C; Bos, M; Colon, A; Dings, J; Hoogland, G; Rijkers, K; Rouhl, RPW; Schijns, OEMG; Sloekers, JCT; Theunissen, M; van Kuijk, S, 2019) |
| " Although it has been reported that AM404, a metabolite of acetaminophen, has anticonvulsant effects in several animal seizure models, little is known about the relation between acetaminophen and seizures." | 3.88 | Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs. ( Araki, H; Aso, H; Suemaru, K; Tanaka, A; Watanabe, M; Yoshikawa, M, 2018) |
| "Acetaminophen metabolism and clearance after a single 1 gm oral dose of the drug was investigated in 12 healthy men, six of whom were cigarette smokers, and in six men who were receiving anticonvulsant drugs for epilepsy." | 3.67 | Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways. ( Attwood, J; Birkett, DJ; Miners, JO, 1984) |
| "Recently, seizure-induced cyclooxygenase (COX)-mediated postictal vasoconstriction, accompanied by cerebral hypoperfusion and hypoxia, has been identified as a candidate mechanism in experimentally induced seizures in rats." | 3.11 | Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE). ( Hofmeijer, J; Pottkämper, JCM; van Putten, MJAM; van Waarde, JA; van Wingen, GA; Verdijk, JPAJ; Verwijk, E, 2022) |
| "Secondary outcome measures are postoperative pain intensity scores, psychological parameters, length of hospital stay and adverse events and will be reassessed at 3 and 6 months after surgery, with a baseline measurement preoperatively." | 2.90 | Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial. ( Bastiaenen, C; Bos, M; Colon, A; Dings, J; Hoogland, G; Rijkers, K; Rouhl, RPW; Schijns, OEMG; Sloekers, JCT; Theunissen, M; van Kuijk, S, 2019) |
| "Pharmacotherapy in pregnancy is often problematic, since both the mother-to-be and her doctor are often concerned about possible risks for the unborn child." | 2.42 | [Drug therapy in pregnancy--a practical guide]. ( Kreienberg, R; Paulus, W; Reister, F, 2004) |
| " Our aim was to translate a recently published comprehensive CNS physiologically-based pharmacokinetic (PBPK) model from rat to human, and to predict drug concentration-time profiles in multiple CNS compartments on available human data of four drugs (acetaminophen, oxycodone, morphine and phenytoin)." | 1.48 | Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach. ( Beukers, MW; Danhof, M; de Lange, ECM; Huntjens, DR; Kokki, H; Kokki, M; Krauwinkel, W; Proost, JH; Välitalo, PA; van Hasselt, JGC; Vermeulen, A; Wong, YC; Yamamoto, Y, 2018) |
| "Migraine is common in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) but its treatment responses are not well described, and its relationship to stroke risk unknown." | 1.43 | CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships. ( Markus, HS; Tan, RY, 2016) |
| "Ibuprofen was more effective against the primary generalized model." | 1.27 | Attenuation of penicillin models of epilepsy by nonsteroidal anti-inflammatory drugs. ( Wallenstein, MC, 1987) |
| "A high proportion of toxic and carcinogenic effects of chemicals develop through the pathway of lethal synthesis." | 1.26 | The influence of nutrition and inducers on mechanisms of toxicity in humans and animals. ( McLean, AE; Tame, D; Witts, DJ, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (46.67) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Verdijk, JPAJ | 1 |
| Pottkämper, JCM | 1 |
| Verwijk, E | 1 |
| van Wingen, GA | 1 |
| van Putten, MJAM | 1 |
| Hofmeijer, J | 1 |
| van Waarde, JA | 1 |
| Sha, L | 1 |
| Li, G | 1 |
| Zhang, X | 1 |
| Lin, Y | 1 |
| Qiu, Y | 1 |
| Deng, Y | 1 |
| Zhu, W | 1 |
| Xu, Q | 1 |
| Sloekers, JCT | 1 |
| Bos, M | 1 |
| Hoogland, G | 1 |
| Bastiaenen, C | 1 |
| van Kuijk, S | 1 |
| Theunissen, M | 1 |
| Rijkers, K | 1 |
| Dings, J | 1 |
| Colon, A | 1 |
| Rouhl, RPW | 1 |
| Schijns, OEMG | 1 |
| Yamamoto, Y | 1 |
| Välitalo, PA | 1 |
| Wong, YC | 1 |
| Huntjens, DR | 1 |
| Proost, JH | 1 |
| Vermeulen, A | 1 |
| Krauwinkel, W | 1 |
| Beukers, MW | 1 |
| Kokki, H | 1 |
| Kokki, M | 1 |
| Danhof, M | 1 |
| van Hasselt, JGC | 1 |
| de Lange, ECM | 1 |
| Suemaru, K | 1 |
| Yoshikawa, M | 1 |
| Tanaka, A | 1 |
| Araki, H | 1 |
| Aso, H | 1 |
| Watanabe, M | 1 |
| Tan, RY | 1 |
| Markus, HS | 1 |
| Reister, F | 1 |
| Paulus, W | 1 |
| Kreienberg, R | 1 |
| Miners, JO | 1 |
| Attwood, J | 1 |
| Birkett, DJ | 1 |
| Kapetanović, IM | 1 |
| Kupferberg, HJ | 1 |
| Theodore, W | 1 |
| Porter, RJ | 1 |
| McLean, AE | 2 |
| Witts, DJ | 1 |
| Tame, D | 1 |
| Goldberg, DM | 1 |
| Ernouf, D | 1 |
| Boussa, N | 1 |
| Wallenstein, MC | 1 |
| Minton, NA | 1 |
| Henry, JA | 1 |
| Frankel, RJ | 1 |
| Driver, HE | 1 |
| McDanell, R | 1 |
| Tacchi-Bedford, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| StudY of Effect of Nimodipine and Acetaminophen on Postictal Symptoms After ECT[NCT04028596] | Phase 2 | 34 participants (Actual) | Interventional | 2019-12-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for acetaminophen and Aura
| Article | Year |
|---|---|
[Drug therapy in pregnancy--a practical guide].
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Bacte | 2004 |
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry.
Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; E | 1980 |
The influence of diet on activation and inactivation of chemicals--evidence from animals and man.
Topics: 1,2-Dimethylhydrazine; Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Co | 1986 |
2 trials available for acetaminophen and Aura
| Article | Year |
|---|---|
Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE).
Topics: Acetaminophen; Animals; Depressive Disorder, Major; Electroconvulsive Therapy; Electroencephalograph | 2022 |
Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug Combinations; | 2019 |
10 other studies available for acetaminophen and Aura
| Article | Year |
|---|---|
Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice.
Topics: Acetaminophen; Animals; Anticonvulsants; Epilepsy; Epilepsy, Temporal Lobe; Excitatory Amino Acid Tr | 2022 |
Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach.
Topics: Acetaminophen; Animals; Biological Transport; Brain; Brain Injuries, Traumatic; Central Nervous Syst | 2018 |
Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cyclooxygenase Inh | 2018 |
CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships.
Topics: Acetaminophen; Adult; Age of Onset; Aged; Aged, 80 and over; Analgesics; CADASIL; Codeine; Cross-Sec | 2016 |
Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways.
Topics: Acetaminophen; Administration, Oral; Adult; Anticonvulsants; Biotransformation; Cimetidine; Drug Int | 1984 |
Lack of effect of valproate on paracetamol (acetaminophen) disposition in epileptic patients.
Topics: Acetaminophen; Adult; Drug Interactions; Epilepsy; Humans; Kinetics; Male; Valproic Acid | 1981 |
The influence of nutrition and inducers on mechanisms of toxicity in humans and animals.
Topics: Acetaminophen; Animals; Anticonvulsants; Calcium; Carcinogens; Cytochrome P-450 Enzyme System; Epile | 1980 |
[Paracetamol, a good analgesic? Yes, but ...].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Epilepsy; Humans | 1990 |
Attenuation of penicillin models of epilepsy by nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids | 1987 |
Fatal paracetamol poisoning in an epileptic.
Topics: Acetaminophen; Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clobazam; Cytochrome | 1988 |