Page last updated: 2024-10-22

acetaminophen and Aura

acetaminophen has been researched along with Aura in 15 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

ExcerptRelevanceReference
"Secondary outcome measures are postoperative pain intensity scores, psychological parameters, length of hospital stay and adverse events and will be reassessed at 3 and 6 months after surgery, with a baseline measurement preoperatively."6.90Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial. ( Bastiaenen, C; Bos, M; Colon, A; Dings, J; Hoogland, G; Rijkers, K; Rouhl, RPW; Schijns, OEMG; Sloekers, JCT; Theunissen, M; van Kuijk, S, 2019)
" Although it has been reported that AM404, a metabolite of acetaminophen, has anticonvulsant effects in several animal seizure models, little is known about the relation between acetaminophen and seizures."3.88Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs. ( Araki, H; Aso, H; Suemaru, K; Tanaka, A; Watanabe, M; Yoshikawa, M, 2018)
"Acetaminophen metabolism and clearance after a single 1 gm oral dose of the drug was investigated in 12 healthy men, six of whom were cigarette smokers, and in six men who were receiving anticonvulsant drugs for epilepsy."3.67Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways. ( Attwood, J; Birkett, DJ; Miners, JO, 1984)
"Recently, seizure-induced cyclooxygenase (COX)-mediated postictal vasoconstriction, accompanied by cerebral hypoperfusion and hypoxia, has been identified as a candidate mechanism in experimentally induced seizures in rats."3.11Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE). ( Hofmeijer, J; Pottkämper, JCM; van Putten, MJAM; van Waarde, JA; van Wingen, GA; Verdijk, JPAJ; Verwijk, E, 2022)
"Secondary outcome measures are postoperative pain intensity scores, psychological parameters, length of hospital stay and adverse events and will be reassessed at 3 and 6 months after surgery, with a baseline measurement preoperatively."2.90Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial. ( Bastiaenen, C; Bos, M; Colon, A; Dings, J; Hoogland, G; Rijkers, K; Rouhl, RPW; Schijns, OEMG; Sloekers, JCT; Theunissen, M; van Kuijk, S, 2019)
"Pharmacotherapy in pregnancy is often problematic, since both the mother-to-be and her doctor are often concerned about possible risks for the unborn child."2.42[Drug therapy in pregnancy--a practical guide]. ( Kreienberg, R; Paulus, W; Reister, F, 2004)
" Our aim was to translate a recently published comprehensive CNS physiologically-based pharmacokinetic (PBPK) model from rat to human, and to predict drug concentration-time profiles in multiple CNS compartments on available human data of four drugs (acetaminophen, oxycodone, morphine and phenytoin)."1.48Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach. ( Beukers, MW; Danhof, M; de Lange, ECM; Huntjens, DR; Kokki, H; Kokki, M; Krauwinkel, W; Proost, JH; Välitalo, PA; van Hasselt, JGC; Vermeulen, A; Wong, YC; Yamamoto, Y, 2018)
"Migraine is common in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) but its treatment responses are not well described, and its relationship to stroke risk unknown."1.43CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships. ( Markus, HS; Tan, RY, 2016)
"Ibuprofen was more effective against the primary generalized model."1.27Attenuation of penicillin models of epilepsy by nonsteroidal anti-inflammatory drugs. ( Wallenstein, MC, 1987)
"A high proportion of toxic and carcinogenic effects of chemicals develop through the pathway of lethal synthesis."1.26The influence of nutrition and inducers on mechanisms of toxicity in humans and animals. ( McLean, AE; Tame, D; Witts, DJ, 1980)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19907 (46.67)18.7374
1990's1 (6.67)18.2507
2000's1 (6.67)29.6817
2010's4 (26.67)24.3611
2020's2 (13.33)2.80

Authors

AuthorsStudies
Verdijk, JPAJ1
Pottkämper, JCM1
Verwijk, E1
van Wingen, GA1
van Putten, MJAM1
Hofmeijer, J1
van Waarde, JA1
Sha, L1
Li, G1
Zhang, X1
Lin, Y1
Qiu, Y1
Deng, Y1
Zhu, W1
Xu, Q1
Sloekers, JCT1
Bos, M1
Hoogland, G1
Bastiaenen, C1
van Kuijk, S1
Theunissen, M1
Rijkers, K1
Dings, J1
Colon, A1
Rouhl, RPW1
Schijns, OEMG1
Yamamoto, Y1
Välitalo, PA1
Wong, YC1
Huntjens, DR1
Proost, JH1
Vermeulen, A1
Krauwinkel, W1
Beukers, MW1
Kokki, H1
Kokki, M1
Danhof, M1
van Hasselt, JGC1
de Lange, ECM1
Suemaru, K1
Yoshikawa, M1
Tanaka, A1
Araki, H1
Aso, H1
Watanabe, M1
Tan, RY1
Markus, HS1
Reister, F1
Paulus, W1
Kreienberg, R1
Miners, JO1
Attwood, J1
Birkett, DJ1
Kapetanović, IM1
Kupferberg, HJ1
Theodore, W1
Porter, RJ1
McLean, AE2
Witts, DJ1
Tame, D1
Goldberg, DM1
Ernouf, D1
Boussa, N1
Wallenstein, MC1
Minton, NA1
Henry, JA1
Frankel, RJ1
Driver, HE1
McDanell, R1
Tacchi-Bedford, AM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
StudY of Effect of Nimodipine and Acetaminophen on Postictal Symptoms After ECT[NCT04028596]Phase 234 participants (Actual)Interventional2019-12-05Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for acetaminophen and Aura

ArticleYear
[Drug therapy in pregnancy--a practical guide].
    MMW Fortschritte der Medizin, 2004, Mar-11, Volume: 146, Issue:11

    Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Bacte

2004
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry.
    Clinical chemistry, 1980, Volume: 26, Issue:6

    Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; E

1980
The influence of diet on activation and inactivation of chemicals--evidence from animals and man.
    Developments in toxicology and environmental science, 1986, Volume: 12

    Topics: 1,2-Dimethylhydrazine; Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Co

1986

Trials

2 trials available for acetaminophen and Aura

ArticleYear
Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE).
    Trials, 2022, Apr-18, Volume: 23, Issue:1

    Topics: Acetaminophen; Animals; Depressive Disorder, Major; Electroconvulsive Therapy; Electroencephalograph

2022
Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial.
    BMJ open, 2019, 09-03, Volume: 9, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug Combinations;

2019

Other Studies

10 other studies available for acetaminophen and Aura

ArticleYear
Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice.
    JCI insight, 2022, 08-08, Volume: 7, Issue:15

    Topics: Acetaminophen; Animals; Anticonvulsants; Epilepsy; Epilepsy, Temporal Lobe; Excitatory Amino Acid Tr

2022
Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018, Jan-15, Volume: 112

    Topics: Acetaminophen; Animals; Biological Transport; Brain; Brain Injuries, Traumatic; Central Nervous Syst

2018
Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs.
    Epilepsy research, 2018, Volume: 140

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cyclooxygenase Inh

2018
CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships.
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Acetaminophen; Adult; Age of Onset; Aged; Aged, 80 and over; Analgesics; CADASIL; Codeine; Cross-Sec

2016
Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways.
    Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:4

    Topics: Acetaminophen; Administration, Oral; Adult; Anticonvulsants; Biotransformation; Cimetidine; Drug Int

1984
Lack of effect of valproate on paracetamol (acetaminophen) disposition in epileptic patients.
    British journal of clinical pharmacology, 1981, Volume: 11, Issue:4

    Topics: Acetaminophen; Adult; Drug Interactions; Epilepsy; Humans; Kinetics; Male; Valproic Acid

1981
The influence of nutrition and inducers on mechanisms of toxicity in humans and animals.
    Ciba Foundation symposium, 1980, Volume: 76

    Topics: Acetaminophen; Animals; Anticonvulsants; Calcium; Carcinogens; Cytochrome P-450 Enzyme System; Epile

1980
[Paracetamol, a good analgesic? Yes, but ...].
    Le Chirurgien-dentiste de France, 1990, Feb-08, Volume: 60, Issue:505

    Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Epilepsy; Humans

1990
Attenuation of penicillin models of epilepsy by nonsteroidal anti-inflammatory drugs.
    Experimental neurology, 1987, Volume: 98, Issue:1

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids

1987
Fatal paracetamol poisoning in an epileptic.
    Human toxicology, 1988, Volume: 7, Issue:1

    Topics: Acetaminophen; Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clobazam; Cytochrome

1988