Page last updated: 2024-10-22

acetaminophen and Asthma, Bronchial

acetaminophen has been researched along with Asthma, Bronchial in 199 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

ExcerptRelevanceReference
"To prospectively evaluate associations between acetaminophen use and asthma in 300 children aged 1-5 years, we conducted a double blind, randomized, controlled trial where parents administered blinded forms of either acetaminophen or ibuprofen as needed to their children over a 48 week period."9.41Adherence rates during a randomized controlled trial evaluating the use of blinded acetaminophen and ibuprofen in children with asthma. ( Cabana, MD; Covar, R; Fitzpatrick, AM; Jackson, DJ; Mauger, DT; Moy, JN; Paul, IM; Phipatanakul, W; Robison, RG; Sheehan, WJ; Szefler, SJ, 2021)
"The Paracetamol and Ibuprofen in Primary Prevention of Asthma in Tamariki trial is a multicentre, open-label, two-arm parallel randomised controlled trial."9.34Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol. ( Asher, I; Beasley, R; Braithwaite, I; Dalziel, SR; Grant, C; Hoare, K; Johnson, D; McKinlay, C; Okesene-Gafa, K; Riley, J; Semprini, A; Sheridan, N; Tan, E; Weatherall, M, 2020)
"To undertake a randomised controlled trial (RCT) of paracetamol versus ibuprofen use during infancy to determine if paracetamol is associated with an increased risk of developing asthma, the preferred method of recruitment needs to be determined."9.22Pilot study of feasibility of a randomised controlled trial of asthma risk with paracetamol versus ibuprofen use in infancy. ( Beasley, R; Braithwaite, I; Dalziel, SR; Hunt, A; McDouall, A; Mitchell, EA; Riley, J; Stanley, T; Waqanivavalagi, S; Weatherall, M, 2016)
"Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking."9.22Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. ( Bacharier, LB; Baxi, SN; Beigelman, A; Benson, M; Blake, K; Boehmer, SJ; Cabana, MD; Chmiel, JF; Covar, R; Daines, CL; Daines, MO; Fitzpatrick, AM; Gaffin, JM; Gentile, DA; Gower, WA; Holguin, F; Israel, E; Jackson, DJ; Kumar, HV; Lang, JE; Lazarus, SC; Lemanske, RF; Lima, JJ; Ly, N; Marbin, J; Martinez, FD; Mauger, DT; Morgan, WJ; Moy, JN; Myers, RE; Olin, JT; Paul, IM; Peters, SP; Phipatanakul, W; Pongracic, JA; Raissy, HH; Robison, RG; Ross, K; Sheehan, WJ; Sorkness, CA; Szefler, SJ; Thyne, SM; Wechsler, ME, 2016)
"Accumulating evidence suggests that the use of acetaminophen increases the risk of developing asthma and that its widespread use has contributed to the increasing prevalence of asthma."9.17The effect of a single dose of acetaminophen on airways response in children with asthma. ( Farber, M; Sivan, Y; Soferman, R; Tsivion, A, 2013)
"Rather than supporting the hypothesis that ibuprofen increases asthma morbidity among children who are not known to be sensitive to aspirin or other nonsteroidal antiinflammatory drugs, these data suggest that compared with acetaminophen, ibuprofen may reduce such risks."9.10Asthma morbidity after the short-term use of ibuprofen in children. ( Lesko, SM; Louik, C; Mitchell, AA; Vezina, RM, 2002)
"Cross-sensitivity between aspirin and acetaminophen in aspirin-sensitive asthmatic patients has been reported with frequencies ranging from 0% to 29%."9.08Prevalence of cross-sensitivity with acetaminophen in aspirin-sensitive asthmatic subjects. ( Christiansen, SC; Mathison, DA; Schrank, PJ; Settipane, RA; Simon, RA; Stevenson, DD, 1995)
"Ten aspirin (ASA)-sensitive patients with asthma underwent double-blind, placebo-controlled oral challenges with salsalate followed by ASA-sensitive confirmatory challenges."9.06Salsalate cross-sensitivity in aspirin-sensitive patients with asthma. ( Goldlust, MB; Hougham, AJ; Schrank, PJ; Stevenson, DD; Wilson, RR, 1990)
"Because aspirin (ASA) is often reported to have an adverse effect on pulmonary function in children with chronic asthma, acetaminophen is commonly used as an ASA substitute in these children."9.05Adverse pulmonary responses to aspirin and acetaminophen in chronic childhood asthma. ( Fischer, TJ; Gartside, PS; Guilfoile, TD; Kearns, GL; Kesarwala, HH; Moomaw, CJ; Winant, JG, 1983)
"We conducted a meta-analysis of randomized controlled trials (RCTs) that compared wheezing and asthma exacerbations in children taking paracetamol versus ibuprofen."9.05Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials. ( Furuya-Kanamori, L; Nader, JD; Sherbash, M; Thalib, L, 2020)
"Increased use of acetaminophen (paracetamol) as the favored antipyretic during pregnancy and infancy has been hypothesized to be a risk factor for the development of asthma."8.90The association between acetaminophen and asthma: is there anything to learn from the upper airways? ( Johnson, CC; Kim, H, 2014)
"The possible association between acetaminophen use during pregnancy and childhood asthma has been a subject of interest based on the theory that acetaminophen metabolism may deplete glutathione in the developing lung, leading to oxidative damage and inflammation."8.86Childhood asthma and use during pregnancy of acetaminophen. A critical review. ( Ang, R; Breitmeyer, J; Royal, MA; Scialli, AR, 2010)
"A growing number of studies show that regular use of acetaminophen (paracetamol) carries a dose-dependent risk of developing allergies in general and asthma in particular and of worsening other respiratory diseases and lung function."8.85Acetaminophen use: a risk for asthma? ( Allmers, H; John, SM; Skudlik, C, 2009)
"Epidemiologic studies have identified an increased risk of asthma with acetaminophen use, but the results have been conflicting."8.85Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis. ( Aminzadeh, K; Doyle-Waters, M; Etminan, M; FitzGerald, JM; Jafari, S; Sadatsafavi, M, 2009)
"Although many studies have investigated the safety and tolerability of ibuprofen or acetaminophen (paracetamol) use in children, few have specifically examined the association of ibuprofen or acetaminophen and the occurrence of asthma in pediatric populations."8.84A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. ( Dale, S; Kanabar, D; Rawat, M, 2007)
"Epidemiologic studies have demonstrated associations between acetaminophen use and asthma."7.88Leptin receptor gene polymorphisms and sex modify the association between acetaminophen use and asthma among young adults: results from two observational studies. ( Arshad, H; Ewart, S; Karmaus, W; Kurukulaaratchy, RJ; Mukherjee, N; Zhang, H; Ziyab, AH, 2018)
"Some studies have suggested that maternal acetaminophen use during pregnancy is associated with asthma in the offspring, and coffee consumption may modify the toxicity of acetaminophen."7.83Association of prenatal exposure to acetaminophen and coffee with childhood asthma. ( Agerbo, E; Bech, BH; Li, J; Liew, Z; Liu, X; Olsen, J; Pedersen, LH; Yuan, W, 2016)
"Unadjusted models showed an increased asthma risk in early childhood for higher infant acetaminophen (odds ratio [OR], 1."7.81Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children. ( Bunyavanich, S; Camargo, CA; Gillman, MW; Gold, DR; Litonjua, AA; Rifas-Shiman, SL; Scirica, CV; Sordillo, JE; Weiss, ST, 2015)
"During pregnancy, acetaminophen is one of the very few medications recommended by physicians to treat fever or pain."7.81Prenatal acetaminophen induces liver toxicity in dams, reduces fetal liver stem cells, and increases airway inflammation in adult offspring. ( Arck, P; Barikbin, R; Erhardt, A; Huebener, P; Karimi, K; Keßler, T; Ramisch, K; Thiele, K; Tiegs, G, 2015)
"The risk of asthma has been increasing in parallel with use of acetaminophen, which is a potential source of oxidative stress."7.80Association between recent acetaminophen use and asthma: modification by polymorphism at TLR4. ( Hong, K; Hong, SJ; Jung, YH; Kang, MJ; Kim, BJ; Kim, HB; Kim, HJ; Kim, HS; Kim, HY; Kim, YJ; Kwon, JW; Lee, SH; Lee, SY; Park, KS; Seo, JH; Yu, HS, 2014)
"Studies have examined the association between acetaminophen use and asthma; however, their interpretation is limited by several methodologic issues."7.78Prescription-acquired acetaminophen use and the risk of asthma in adults: a case-control study. ( Cleves, MA; Foster, HR; Hogan, WR; James, LP; Kelkar, M; Martin, BC, 2012)
"There is epidemiological evidence that the use of acetaminophen may increase the risk of developing asthma."7.77Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International Study of Asthma and Allergies in Childhood Phase Three. ( Beasley, RW; Clayton, TO; Crane, J; Lai, CK; Montefort, SR; Mutius, Ev; Stewart, AW, 2011)
"The epidemiologic association between acetaminophen use and asthma prevalence and severity in children and adults is well established."7.77The association of acetaminophen and asthma prevalence and severity. ( McBride, JT, 2011)
"Prenatal and infant acetaminophen exposure has been associated with an increased risk of childhood asthma phenotypes."7.76Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma. ( Henderson, AJ; Holloway, JW; Newson, RB; Ring, SM; Rose-Zerilli, MJ; Shaheen, SO, 2010)
"To estimate whether prenatal exposure to acetaminophen is associated with risk of diagnosed asthma and asthma symptoms in children."7.75Prenatal exposure to acetaminophen and asthma in children. ( Bracken, MB; Illuzzi, JL; Kang, EM; Lundsberg, LS, 2009)
"To establish the relationship between the use of acetaminophen and the frequency of asthma in Mexican children in 3 Mexican cities."7.74Study of the relationship between acetaminophen and asthma in Mexican children aged 6 to 7 years in 3 Mexican cities using ISAAC methodology. ( Baeza-Bacab, M; Berber, A; Del-Rio-Navarro, BE; Garcia-Almaraz, R; Ito-Tsuchiya, FM; Sienra-Monge, JJ; Zepeda-Ortega, B, 2008)
"The purpose of this study was to investigate the risk of transitional cell carcinoma among subjects with an intake of acetaminophen, aspirin, some other drugs and with some intercurrent diseases."7.69Acetaminophen, some other drugs, some diseases and the risk of transitional cell carcinoma. A population-based case-control study. ( Gerhardsson de Verdier, M; Steineck, G; Wiholm, BE, 1995)
"To determine whether the different modes of action of aspirin and acetaminophen are associated with different incidences of bronchoconstriction, and whether there is cross-reactivity in terms of intolerance, selected asthmatics were challenged with both analgesics."7.66Acetaminophen and aspirin challenges in subgroups of asthmatics. ( Falliers, CJ, 1983)
" Rather, dosing for adults who are older and/or have decompensated cirrhosis, advanced kidney failure, or analgesic-induced asthma that is known to be cross-sensitive to paracetamol, should be individualized in consultation with their physician, who may recommend a lower effective dose appropriate to the circumstances."6.82Why paracetamol (acetaminophen) is a suitable first choice for treating mild to moderate acute pain in adults with liver, kidney or cardiovascular disease, gastrointestinal disorders, asthma, or who are older. ( Alchin, J; Christo, PJ; Dhar, A; Siddiqui, K, 2022)
"Acetaminophen is a widely used medication for the treatment of pain and fever in children and pregnant women."6.49Acetaminophen and asthma. ( Henderson, AJ; Shaheen, SO, 2013)
" The Paracetamol and Ibuprofen in the Primary Prevention of Asthma in Tamariki (PIPPA Tamariki) trial is an open-label, randomised controlled trial aiming to determine whether paracetamol treatment, compared with ibuprofen treatment, as required for fever and pain in the first year of life, increases the risk of asthma at age six years."5.51Panic or peace - prioritising infant welfare when medicating feverish infants: a grounded theory study of adherence in a paediatric clinical trial. ( Braithwaite, I; Dalziel, SR; Fernando, K; Haskell, L; Hoare, K; McKinlay, CJ; Riley, J; Tan, E, 2022)
"To prospectively evaluate associations between acetaminophen use and asthma in 300 children aged 1-5 years, we conducted a double blind, randomized, controlled trial where parents administered blinded forms of either acetaminophen or ibuprofen as needed to their children over a 48 week period."5.41Adherence rates during a randomized controlled trial evaluating the use of blinded acetaminophen and ibuprofen in children with asthma. ( Cabana, MD; Covar, R; Fitzpatrick, AM; Jackson, DJ; Mauger, DT; Moy, JN; Paul, IM; Phipatanakul, W; Robison, RG; Sheehan, WJ; Szefler, SJ, 2021)
"Autism and autism spectrum disorders are enigmatic conditions that have their origins in the interaction of genes and environmental factors."5.36Similarities in features of autism and asthma and a possible link to acetaminophen use. ( Becker, KG; Schultz, ST, 2010)
"The Paracetamol and Ibuprofen in Primary Prevention of Asthma in Tamariki trial is a multicentre, open-label, two-arm parallel randomised controlled trial."5.34Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol. ( Asher, I; Beasley, R; Braithwaite, I; Dalziel, SR; Grant, C; Hoare, K; Johnson, D; McKinlay, C; Okesene-Gafa, K; Riley, J; Semprini, A; Sheridan, N; Tan, E; Weatherall, M, 2020)
"Acetaminophen use has been associated with asthma in cross-sectional studies and a birth cohort."5.32Prospective study of acetaminophen use and newly diagnosed asthma among women. ( Barr, RG; Camargo, CA; Curhan, GC; Schwartz, J; Somers, SC; Speizer, FE; Stampfer, MJ; Wentowski, CC, 2004)
"To undertake a randomised controlled trial (RCT) of paracetamol versus ibuprofen use during infancy to determine if paracetamol is associated with an increased risk of developing asthma, the preferred method of recruitment needs to be determined."5.22Pilot study of feasibility of a randomised controlled trial of asthma risk with paracetamol versus ibuprofen use in infancy. ( Beasley, R; Braithwaite, I; Dalziel, SR; Hunt, A; McDouall, A; Mitchell, EA; Riley, J; Stanley, T; Waqanivavalagi, S; Weatherall, M, 2016)
"Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking."5.22Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. ( Bacharier, LB; Baxi, SN; Beigelman, A; Benson, M; Blake, K; Boehmer, SJ; Cabana, MD; Chmiel, JF; Covar, R; Daines, CL; Daines, MO; Fitzpatrick, AM; Gaffin, JM; Gentile, DA; Gower, WA; Holguin, F; Israel, E; Jackson, DJ; Kumar, HV; Lang, JE; Lazarus, SC; Lemanske, RF; Lima, JJ; Ly, N; Marbin, J; Martinez, FD; Mauger, DT; Morgan, WJ; Moy, JN; Myers, RE; Olin, JT; Paul, IM; Peters, SP; Phipatanakul, W; Pongracic, JA; Raissy, HH; Robison, RG; Ross, K; Sheehan, WJ; Sorkness, CA; Szefler, SJ; Thyne, SM; Wechsler, ME, 2016)
"There is non-experimental evidence that paracetamol (acetaminophen) use may increase the risk of developing asthma."5.20Randomized controlled trial of asthma risk with paracetamol use in infancy--a feasibility study. ( Beasley, R; Bowden, V; Braithwaite, I; Caswell-Smith, R; Crane, J; Hunt, A; Ingham, T; Mitchell, EA; Power, S; Riley, J; Shirtcliffe, P; Stanley, T; Weatherall, M, 2015)
"Accumulating evidence suggests that the use of acetaminophen increases the risk of developing asthma and that its widespread use has contributed to the increasing prevalence of asthma."5.17The effect of a single dose of acetaminophen on airways response in children with asthma. ( Farber, M; Sivan, Y; Soferman, R; Tsivion, A, 2013)
"An increasing number of cohort studies have suggested that maternal use of acetaminophen during pregnancy was associated with increased risk for asthma; neurodevelopmental disorders, especially ADHD and behavioral problems; and genital malformations in the offspring."5.12Intrauterine Exposure to Acetaminophen and Adverse Developmental Outcomes: Epidemiological Findings and Methodological Issues. ( Ernst, A; Liew, Z, 2021)
"Rather than supporting the hypothesis that ibuprofen increases asthma morbidity among children who are not known to be sensitive to aspirin or other nonsteroidal antiinflammatory drugs, these data suggest that compared with acetaminophen, ibuprofen may reduce such risks."5.10Asthma morbidity after the short-term use of ibuprofen in children. ( Lesko, SM; Louik, C; Mitchell, AA; Vezina, RM, 2002)
"To compare the incidence of serious adverse clinical events among children <2 years old given ibuprofen and acetaminophen to control fever."5.09The safety of acetaminophen and ibuprofen among children younger than two years old. ( Lesko, SM; Mitchell, AA, 1999)
"Cross-sensitivity between aspirin and acetaminophen in aspirin-sensitive asthmatic patients has been reported with frequencies ranging from 0% to 29%."5.08Prevalence of cross-sensitivity with acetaminophen in aspirin-sensitive asthmatic subjects. ( Christiansen, SC; Mathison, DA; Schrank, PJ; Settipane, RA; Simon, RA; Stevenson, DD, 1995)
"Ten aspirin (ASA)-sensitive patients with asthma underwent double-blind, placebo-controlled oral challenges with salsalate followed by ASA-sensitive confirmatory challenges."5.06Salsalate cross-sensitivity in aspirin-sensitive patients with asthma. ( Goldlust, MB; Hougham, AJ; Schrank, PJ; Stevenson, DD; Wilson, RR, 1990)
"We conducted a meta-analysis of randomized controlled trials (RCTs) that compared wheezing and asthma exacerbations in children taking paracetamol versus ibuprofen."5.05Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials. ( Furuya-Kanamori, L; Nader, JD; Sherbash, M; Thalib, L, 2020)
"Because aspirin (ASA) is often reported to have an adverse effect on pulmonary function in children with chronic asthma, acetaminophen is commonly used as an ASA substitute in these children."5.05Adverse pulmonary responses to aspirin and acetaminophen in chronic childhood asthma. ( Fischer, TJ; Gartside, PS; Guilfoile, TD; Kearns, GL; Kesarwala, HH; Moomaw, CJ; Winant, JG, 1983)
"First described as a component of a triad seen among adults with nonallergic asthma and nasal polyps, aspirin sensitivity has subsequently been documented as a frequent concomitant of a wide range of patients with chronic asthma."5.04Analgesic sensitivity in children with asthma. ( Weinberger, M, 1978)
"Paracetamol (acetaminophen) is the most commonly used drug in the world, with a long record of use in acute and chronic pain."4.98Long-term adverse effects of paracetamol - a review. ( Dear, JW; MacIntyre, IM; McCrae, JC; Morrison, EE; Webb, DJ, 2018)
" To perform the search for the most suitable and representative articles, keywords were selected ("asthma," "paracetamol" and "acetaminophen")."4.95The association between paracetamol and asthma is still under debate. ( Gonzalez-Barcala, FJ; Lourido-Cebreiro, T; Salgado, FJ; Valdes, L, 2017)
"Increased use of acetaminophen (paracetamol) as the favored antipyretic during pregnancy and infancy has been hypothesized to be a risk factor for the development of asthma."4.90The association between acetaminophen and asthma: is there anything to learn from the upper airways? ( Johnson, CC; Kim, H, 2014)
"Although the use of acetaminophen is weakly associated with asthma/wheezing, the widespread use of the drug might have important public health implications."4.87Early exposure to acetaminophen and allergic disorders. ( Garcia-Marcos, L; Perez-Fernandez, V; Sanchez-Solis, M, 2011)
"The possible association between acetaminophen use during pregnancy and childhood asthma has been a subject of interest based on the theory that acetaminophen metabolism may deplete glutathione in the developing lung, leading to oxidative damage and inflammation."4.86Childhood asthma and use during pregnancy of acetaminophen. A critical review. ( Ang, R; Breitmeyer, J; Royal, MA; Scialli, AR, 2010)
"Epidemiologic studies have identified an increased risk of asthma with acetaminophen use, but the results have been conflicting."4.85Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis. ( Aminzadeh, K; Doyle-Waters, M; Etminan, M; FitzGerald, JM; Jafari, S; Sadatsafavi, M, 2009)
"A growing number of studies show that regular use of acetaminophen (paracetamol) carries a dose-dependent risk of developing allergies in general and asthma in particular and of worsening other respiratory diseases and lung function."4.85Acetaminophen use: a risk for asthma? ( Allmers, H; John, SM; Skudlik, C, 2009)
"Although many studies have investigated the safety and tolerability of ibuprofen or acetaminophen (paracetamol) use in children, few have specifically examined the association of ibuprofen or acetaminophen and the occurrence of asthma in pediatric populations."4.84A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. ( Dale, S; Kanabar, D; Rawat, M, 2007)
"This paper describes two studies in children with fever in which the safety of ibuprofen was compared with that of paracetamol."4.82The safety of ibuprofen suspension in children. ( Lesko, SM, 2003)
"Aspirin (acetylsalicylic acid) and other nonsteroidal anti-inflammatory drugs (NSAIDs) cause deterioration in respiratory function in approximately 10% of adults with asthma and a smaller proportion of children with asthma."4.81The use of analgesics in patients with asthma. ( Levy, S; Volans, G, 2001)
"Relevant articles in the medical literature were derived from searching the MEDLINE database with key terms aspirin-sensitive asthma, cyclo-oxygenase enzymes 1 and 2."4.81Sensitivity to nonsteroidal anti-inflammatory drugs. ( Namazy, JA; Simon, RA, 2002)
" Both acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to increase the risk of asthma exacerbation."3.96Impact of antipyretics on acute asthma exacerbation during respiratory infection-A nationwide population-based study. ( Chen, YH; Chung, RS; Fu, LS; Huang, YC; Lin, CH, 2020)
"Epidemiologic studies have demonstrated associations between acetaminophen use and asthma."3.88Leptin receptor gene polymorphisms and sex modify the association between acetaminophen use and asthma among young adults: results from two observational studies. ( Arshad, H; Ewart, S; Karmaus, W; Kurukulaaratchy, RJ; Mukherjee, N; Zhang, H; Ziyab, AH, 2018)
"An association of acetaminophen use and asthma was observed in the International Study of Asthma and Allergies in Childhood study."3.85Conjugation of nitrated acetaminophen to Der p1 amplifies peripheral blood monocyte response to Der p1. ( Bederman, IR; Bonfield, TL; Gaston, BM; Hunt, JF; Rivera Acosta, NB; Rivera Reyes, BM; Smith, LA; Sutton, MT; Thomas, RG; Wang, B, 2017)
"Some studies have suggested that maternal acetaminophen use during pregnancy is associated with asthma in the offspring, and coffee consumption may modify the toxicity of acetaminophen."3.83Association of prenatal exposure to acetaminophen and coffee with childhood asthma. ( Agerbo, E; Bech, BH; Li, J; Liew, Z; Liu, X; Olsen, J; Pedersen, LH; Yuan, W, 2016)
"During pregnancy, acetaminophen is one of the very few medications recommended by physicians to treat fever or pain."3.81Prenatal acetaminophen induces liver toxicity in dams, reduces fetal liver stem cells, and increases airway inflammation in adult offspring. ( Arck, P; Barikbin, R; Erhardt, A; Huebener, P; Karimi, K; Keßler, T; Ramisch, K; Thiele, K; Tiegs, G, 2015)
"Unadjusted models showed an increased asthma risk in early childhood for higher infant acetaminophen (odds ratio [OR], 1."3.81Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children. ( Bunyavanich, S; Camargo, CA; Gillman, MW; Gold, DR; Litonjua, AA; Rifas-Shiman, SL; Scirica, CV; Sordillo, JE; Weiss, ST, 2015)
"The risk of asthma has been increasing in parallel with use of acetaminophen, which is a potential source of oxidative stress."3.80Association between recent acetaminophen use and asthma: modification by polymorphism at TLR4. ( Hong, K; Hong, SJ; Jung, YH; Kang, MJ; Kim, BJ; Kim, HB; Kim, HJ; Kim, HS; Kim, HY; Kim, YJ; Kwon, JW; Lee, SH; Lee, SY; Park, KS; Seo, JH; Yu, HS, 2014)
"We observed a positive relationship between acetaminophen and/or antibiotic exposure during the 1st year of life and the subsequent development of the three examined allergic diseases (atopic dermatitis, asthma and allergic rhinitis) in the 1998 birth cohort, but the observed relationship of drug exposure in the 2003 cohort, especially for atopic dermatitis and asthma, was lower than for those in the 1998 cohort and was not statistically significant."3.79Acetaminophen and/or antibiotic use in early life and the development of childhood allergic diseases. ( Chen, CY; Hsiung, CA; Huang, YW; Liu, LF; Tsai, HJ; Wang, JY, 2013)
" I present the recent debate on the causal association between acetaminophen and asthma in order to illustrate the point at issue."3.79Until RCT proven? On the asymmetry of evidence requirements for risk assessment. ( Osimani, B, 2013)
"Studies have examined the association between acetaminophen use and asthma; however, their interpretation is limited by several methodologic issues."3.78Prescription-acquired acetaminophen use and the risk of asthma in adults: a case-control study. ( Cleves, MA; Foster, HR; Hogan, WR; James, LP; Kelkar, M; Martin, BC, 2012)
"The epidemiologic association between acetaminophen use and asthma prevalence and severity in children and adults is well established."3.77The association of acetaminophen and asthma prevalence and severity. ( McBride, JT, 2011)
"There is epidemiological evidence that the use of acetaminophen may increase the risk of developing asthma."3.77Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International Study of Asthma and Allergies in Childhood Phase Three. ( Beasley, RW; Clayton, TO; Crane, J; Lai, CK; Montefort, SR; Mutius, Ev; Stewart, AW, 2011)
"Acetaminophen has been associated with asthma and is in part metabolised via the glutathione pathway."3.76Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort. ( Ali, D; Barr, RG; Chew, GL; Garfinkel, RS; Goldstein, IF; Miller, RL; Perera, FP; Perzanowski, MS; Tang, D, 2010)
"Prenatal and infant acetaminophen exposure has been associated with an increased risk of childhood asthma phenotypes."3.76Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma. ( Henderson, AJ; Holloway, JW; Newson, RB; Ring, SM; Rose-Zerilli, MJ; Shaheen, SO, 2010)
" Multivariable logistic regression analyses showed the region of residence, being born in Canada, recent use of acetaminophen and heavy exposure to traffic exhaust were significantly associated with all three allergic conditions, while obesity and having two or more smokers at home was only associated with increased risk for wheezing."3.76Disparate geographic prevalences of asthma, allergic rhinoconjunctivitis and atopic eczema among adolescents in five Canadian cities. ( Becker, AB; Duncan, JM; Ferguson, AC; Greene, JM; Pizzichini, MM; Rennie, DC; Sears, MR; Senthilselvan, A; Taylor, BW; Wang, HY, 2010)
"To estimate whether prenatal exposure to acetaminophen is associated with risk of diagnosed asthma and asthma symptoms in children."3.75Prenatal exposure to acetaminophen and asthma in children. ( Bracken, MB; Illuzzi, JL; Kang, EM; Lundsberg, LS, 2009)
"Use of acetaminophen in middle to late but not early pregnancy was significantly related to wheezing (odd ratio, 1."3.74Prenatal exposure to acetaminophen and respiratory symptoms in the first year of life. ( Busso, A; Chavez, N; Enriquez, R; Gutierrez, S; Hernandez, E; Pelzel, D; Persky, V; Piorkowski, J; Vergara, C; Wagner-Cassanova, C, 2008)
"Studies from the UK and USA suggest that frequent use of paracetamol (acetaminophen) may increase the risk of asthma, but data across Europe are lacking."3.74The relation between paracetamol use and asthma: a GA2LEN European case-control study. ( Bergmann, KC; Bonini, S; Bruno, A; Burney, P; De Rudder, I; Fokkens, W; Gjomarkaj, M; Gnatiuc, L; Godnic-Cvar, J; Heinzerling, L; Janson, C; Joos, G; Kowalski, ML; Loureiro, C; Makowska, J; Pace, E; Potts, J; Sanjuas, C; Shaheen, S; Skadhauge, L; Thomsen, G; Todo-Bom, A; van Durme, Y; van Zele, T; Villanueva, CM; Weersink, EJ; Wöhrl, S; Zock, JP; Zuberbier, T, 2008)
"To establish the relationship between the use of acetaminophen and the frequency of asthma in Mexican children in 3 Mexican cities."3.74Study of the relationship between acetaminophen and asthma in Mexican children aged 6 to 7 years in 3 Mexican cities using ISAAC methodology. ( Baeza-Bacab, M; Berber, A; Del-Rio-Navarro, BE; Garcia-Almaraz, R; Ito-Tsuchiya, FM; Sienra-Monge, JJ; Zepeda-Ortega, B, 2008)
"We recently found that paracetamol (acetaminophen) use in late pregnancy was associated with an increased risk of early wheezing in the offspring."3.73Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood. ( Headley, JE; Henderson, AJ; Jones, RW; Newson, RB; Shaheen, SO; Strachan, DP; Stratton, FD, 2005)
"To investigate the associations between use of pain medication, particularly acetaminophen, and asthma, COPD, and FEV1 in adults."3.73The association of acetaminophen, aspirin, and ibuprofen with respiratory disease and lung function. ( Britton, JR; Burney, P; Cassano, PA; Lewis, SA; McKeever, TM; Smit, HA, 2005)
"Studies in developed countries suggest that acetaminophen use is associated with increased risk of asthma, but it is unclear whether this association is causal."3.73Use of acetaminophen and the risk of self-reported allergic symptoms and skin sensitization in Butajira, Ethiopia. ( Aref-Adib, G; Berhane, Y; Britton, J; Davey, G; Duncan, P; Venn, A, 2005)
"We recently reported links between frequent paracetamol (acetaminophen) use and wheezing and asthma in adults and children, but data are lacking on possible effects of prenatal exposure on wheezing in early childhood."3.71Paracetamol use in pregnancy and wheezing in early childhood. ( Burney, PG; Golding, J; Henderson, AJ; Heron, JE; Newson, RB; Shaheen, SO; Sherriff, A, 2002)
"The purpose of this study was to investigate the risk of transitional cell carcinoma among subjects with an intake of acetaminophen, aspirin, some other drugs and with some intercurrent diseases."3.69Acetaminophen, some other drugs, some diseases and the risk of transitional cell carcinoma. A population-based case-control study. ( Gerhardsson de Verdier, M; Steineck, G; Wiholm, BE, 1995)
"To determine whether the different modes of action of aspirin and acetaminophen are associated with different incidences of bronchoconstriction, and whether there is cross-reactivity in terms of intolerance, selected asthmatics were challenged with both analgesics."3.66Acetaminophen and aspirin challenges in subgroups of asthmatics. ( Falliers, CJ, 1983)
"Challenge tests with some analgesics in common use were performed in five aspirin-sensitive asthmatics."3.65Response of aspirin-allergic patients to challenge by some analgesics in common use. ( Smith, AP, 1971)
" Rather, dosing for adults who are older and/or have decompensated cirrhosis, advanced kidney failure, or analgesic-induced asthma that is known to be cross-sensitive to paracetamol, should be individualized in consultation with their physician, who may recommend a lower effective dose appropriate to the circumstances."2.82Why paracetamol (acetaminophen) is a suitable first choice for treating mild to moderate acute pain in adults with liver, kidney or cardiovascular disease, gastrointestinal disorders, asthma, or who are older. ( Alchin, J; Christo, PJ; Dhar, A; Siddiqui, K, 2022)
"The rising prevalence of bronchial asthma has led to world-wide efforts to understand and stem this development."2.49The case of drug causation of childhood asthma: antibiotics and paracetamol. ( Heintze, K; Petersen, KU, 2013)
"Acetaminophen is a widely used medication for the treatment of pain and fever in children and pregnant women."2.49Acetaminophen and asthma. ( Henderson, AJ; Shaheen, SO, 2013)
"Pharmacotherapy in pregnancy is often problematic, since both the mother-to-be and her doctor are often concerned about possible risks for the unborn child."2.42[Drug therapy in pregnancy--a practical guide]. ( Kreienberg, R; Paulus, W; Reister, F, 2004)
"Ibuprofen use was significantly lower in children diagnosed with wheezing (n = 22, 52."1.46Association of Acetaminophen and Ibuprofen Use With Wheezing in Children With Acute Febrile Illness. ( Elizur, A; Ganor, S; Kozer, E; Levine, H; Matok, I; Perlman, A, 2017)
"Rhinitis was associated with a greater number of episodes of night cough in adolescents with asthma."1.46Prevalence of asthma and allergies in 13-14-year-old adolescents from Luanda, Angola. ( Arrais, M; Gama, JMR; Lulua, O; Quifica, F; Rosado-Pinto, J; Taborda-Barata, L, 2017)
" Significant positive dose-response effects of early life use were seen in relation to the prevalence of all outcomes at age 5."1.40Effects of early life paracetamol use on the incidence of allergic disease and sensitization: 5 year follow-up of an Ethiopian birth cohort. ( Amberbir, A; Britton, J; Davey, G; Hanlon, C; Medhin, G; Venn, A, 2014)
"Using plasma from APAP poisoned mice, either lethally (500 mg/kg) or sublethally (150 mg/kg) dosed, we screened commercially available murine microRNA libraries (SABiosciences, Qiagen Sciences, MD) to evaluate for unique miRNA profiles between these two dosing parameters."1.38Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: a research study. ( Bala, S; Petrasek, J; Szabo, G; Ward, J, 2012)
"Autism and autism spectrum disorders are enigmatic conditions that have their origins in the interaction of genes and environmental factors."1.36Similarities in features of autism and asthma and a possible link to acetaminophen use. ( Becker, KG; Schultz, ST, 2010)
"Acetaminophen use has been associated with asthma in cross-sectional studies and a birth cohort."1.32Prospective study of acetaminophen use and newly diagnosed asthma among women. ( Barr, RG; Camargo, CA; Curhan, GC; Schwartz, J; Somers, SC; Speizer, FE; Stampfer, MJ; Wentowski, CC, 2004)
"Nimesulide was tolerated by 115/122 (94."1.30Long-term tolerability of nimesulide and acetaminophen in nonsteroidal antiinflammatory drug-intolerant patients. ( D'Ambrosio, FP; Di Fonso, M; Giuffreda, F; Papa, G; Quaratino, D; Romano, A; Venuti, A, 1997)

Research

Studies (199)

TimeframeStudies, this research(%)All Research%
pre-199018 (9.05)18.7374
1990's8 (4.02)18.2507
2000's62 (31.16)29.6817
2010's97 (48.74)24.3611
2020's14 (7.04)2.80

Authors

AuthorsStudies
Liew, Z3
Yuan, Y1
Meng, Q1
von Ehrenstein, OS1
Cui, X1
Flores, MES1
Ritz, B1
Alchin, J1
Dhar, A1
Siddiqui, K1
Christo, PJ1
Tan, E2
Hoare, K2
Riley, J4
Fernando, K1
Haskell, L1
McKinlay, CJ1
Dalziel, SR3
Braithwaite, I6
Ahmetaj, L1
Martínez-Torres, AE1
Ahmetaj, Y1
Ismajli, I1
Gashi, V1
Kurhasani, X1
Lokaj-Berisha, V1
Lumezi, B1
Lleshi, L1
Pajaziti, L1
Shahini, M1
Zhjeqi, V1
García-Marcos, L5
Peñaranda, A1
Pérez-Herrera, LC1
Gantiva, M1
Moreno-López, S1
Manrique, J1
Peñaranda, D1
García, E1
Karpińska, G1
Dobrowolski, JC1
Yinda, CK1
Rector, A1
Zeller, M1
Conceição-Neto, N1
Heylen, E1
Maes, P1
Ghogomu, SM1
Van Ranst, M1
Matthijnssens, J1
Arthanari, SK1
Vanitha, J1
Ganesh, M1
Venkateshwaran, K1
de Lama Caro-Patón, G1
García-Salido, A1
Iglesias-Bouzas, MI1
Guillén, M1
Cañedo-Villaroya, E1
Martínez-Romera, I1
Serrano-González, A1
Casado-Flores, J1
Gale, P2
Chen, X2
Li, H1
Lucero-Prisno, DE1
Abdullah, AS1
Huang, J1
Laurence, C1
Liang, X1
Ma, Z1
Mao, Z1
Ren, R1
Wu, S1
Wang, N1
Wang, P2
Wang, T1
Yan, H1
Zou, Y1
Olsen, KM1
Gabler, NK1
Rademacher, CJ1
Schwartz, KJ1
Schweer, WP1
Gourley, GG1
Patience, JF1
Rauch, JC1
Stokes, RS1
Shike, DW1
Luebbe, KM1
Stalker, LA1
Klopfenstein, TJ1
Funston, RN1
Unger, PA1
Lighaam, LC1
Vermeulen, E1
Kruithof, S1
Makuch, M1
Culver, EL1
van Bruggen, R1
Remmerswaal, EBM1
Ten Berge, IJM1
Emmens, RW1
Niessen, HWM1
Barnes, E1
Wolbink, GJ1
van Ham, SM1
Rispens, T1
Liang, JX1
Lin, J1
Liu, J1
Wang, X1
Zhang, T1
Li, J2
Wu, Y2
Venier, M1
Salamova, A1
Gonçales, VR1
Lian, J1
Gautam, S1
Tilley, RD1
Gooding, JJ1
Kandel, YR1
Bradley, CA1
Chilvers, MI1
Mathew, FM1
Tenuta, AU1
Smith, DL1
Wise, KA1
Mueller, DS1
Lu, N1
Lu, M1
Liu, P1
Xu, H1
Qiu, X1
Hu, S1
Bai, S1
Wu, J1
Xue, S1
Dai, X1
Dharmage, SC5
Abramson, MJ3
Erbas, B1
Bennett, CM2
Svanes, C1
Hui, J1
Axelrad, C2
Lowe, AJ4
Lodge, CJ2
Hoshi, M1
Osawa, Y1
Nakamoto, K1
Morita, N1
Yamamoto, Y1
Ando, T1
Tashita, C1
Nabeshima, T1
Saito, K1
Gianesello, L1
Del Prete, D1
Ceol, M1
Priante, G1
Calò, LA1
Anglani, F1
Vekaria, HJ1
Hubbard, WB1
Scholpa, NE1
Spry, ML1
Gooch, JL1
Prince, SJ1
Schnellmann, RG1
Sullivan, PG1
Zhang, Q1
Hu, R1
Gu, Z1
Zhang, M1
Zhang, Z1
Peng, Y1
Feng, L1
Li, X3
Zhao, C1
Sarfaraz, K1
Gao, L1
Wang, H1
Wan, C1
Leng, J1
Yang, P1
Gao, X1
Gao, J1
Emam, HE1
Saad, NM1
Abdallah, AEM1
Ahmed, HB1
Palombo, M1
Ianus, A1
Guerreri, M1
Nunes, D1
Alexander, DC1
Shemesh, N1
Zhang, H2
Xiong, Q1
Liu, YS1
Hu, LX1
Shi, ZQ1
Ying, GG1
Chen, R1
Hong, X1
Yan, S1
Zha, J1
Gu, H1
Zhong, Q1
Zeng, Y1
Zhang, S1
Bu, Y1
Farghali, M1
Mayumi, M1
Syo, K1
Satoshi, A1
Seiichi, Y1
Takashima, S1
Ono, H1
Ap, Y1
Yamashiro, T1
Ahmed, MM1
Kotb, S1
Iwasaki, M1
Ihara, I1
Umetsu, K1
Hu, B1
Wang, Y2
Quan, J1
Huang, K1
Gu, X1
Zhu, J1
Yan, Y1
Wu, P1
Yang, L1
Zhao, J1
Koók, L1
Nemestóthy, N1
Bélafi-Bakó, K1
Bakonyi, P1
Luo, X1
Zhang, F1
Li, Q1
Xia, Q1
Li, Z1
Ye, W1
Li, S1
Ge, C1
Zakkula, A1
Pulipati, S1
Dittakavi, S1
Bestha, RM1
Zainuddin, M1
Trivedi, RK1
Mullangi, R1
Lo, GH1
Lin, CW1
Tai, CM1
Perng, DS1
Chen, IL1
Yeh, JH1
Lin, HC1
Rocha, GS1
Silva, MKL1
Cesarino, I1
Hazzaa, SM1
Abdelaziz, SAM1
Abd Eldaim, MA1
Abdel-Daim, MM1
Elgarawany, GE1
Larsson, P1
Ljuslinder, I1
Öhlund, D1
Myte, R1
Löfgren-Burström, A1
Zingmark, C1
Ling, A1
Edin, S1
Palmqvist, R1
Murthi, P1
Rajaraman, G1
Erwich, JJHM1
Dimitriadis, E1
Yoon, HG1
Oh, D1
Ahn, YC1
Noh, JM1
Pyo, H1
Cho, WK1
Song, YM1
Park, M1
Hwang, NY1
Sun, JM1
Kim, HK1
Zo, JI1
Shim, YM1
Persano, A1
Quaranta, F1
Taurino, A1
Siciliano, PA1
Iannacci, J1
Malekbala, MR1
Soltani, S1
Abdul Rashid, S1
Abdullah, LC1
Rashid, U1
Nehdi, IA1
Choong, TSY1
Teo, SH1
Xu, P1
Yan, F1
Zhao, Y1
Sun, S1
Ying, L1
Quinzi, V1
Caruso, S1
Mummolo, S1
Nota, A1
Angelone, AM1
Mattei, A1
Gatto, R1
Marzo, G1
Xin, W1
Severino, J1
Venkert, A1
Yu, H1
Knorr, D1
Yang, JM1
Carlson, L1
Hicks, R1
De Rosa, I1
Beckmann, NA1
Bitsch, RG1
Schonhoff, M1
Siebenrock, KA1
Schwarze, M1
Jaeger, S1
Sherbash, M1
Furuya-Kanamori, L1
Nader, JD1
Thalib, L1
Chung, RS1
Huang, YC1
Chen, YH1
Fu, LS1
Lin, CH1
Ruano, FJ1
Somoza Álvarez, ML1
Haroun-Díaz, E1
Vázquez de la Torre, M1
López González, P1
Prieto-Moreno, A1
Torres Rojas, I1
Cervera García, MD1
Pérez Alzate, D1
Blanca-López, N1
Canto Díez, G1
Juujärvi, S1
Saarela, T1
Pokka, T2
Hallman, M1
Aikio, O1
Bjerg, A1
McKinlay, C1
Okesene-Gafa, K1
Semprini, A1
Sheridan, N1
Grant, C1
Johnson, D1
Weatherall, M7
Asher, I1
Beasley, R11
Ernst, A1
Sheehan, WJ4
Paul, IM3
Mauger, DT3
Moy, JN3
Szefler, SJ3
Jackson, DJ3
Fitzpatrick, AM3
Cabana, MD2
Covar, R2
Robison, RG2
Phipatanakul, W4
Singh, M3
Varukolu, S1
Chauhan, A1
Jaiswal, N1
Pradhan, P1
Mathew, JL1
Arrais, M1
Lulua, O1
Quifica, F1
Rosado-Pinto, J1
Gama, JMR1
Taborda-Barata, L1
Wurth, M1
Papantonakis, CM1
Nevel, RJ1
Thomas, CS1
Sokolow, AG1
Moore, PE1
Rosas-Salazar, C1
Thomas, RG1
Rivera Reyes, BM1
Gaston, BM1
Rivera Acosta, NB1
Bederman, IR1
Smith, LA1
Sutton, MT1
Wang, B1
Hunt, JF1
Bonfield, TL1
Piler, P1
Švancara, J1
Kukla, L1
Pikhart, H1
Morris, CR1
Suh, JH1
McCrae, JC1
Morrison, EE1
MacIntyre, IM1
Dear, JW1
Webb, DJ1
Heinzl, S1
Ziyab, AH1
Mukherjee, N1
Kurukulaaratchy, RJ3
Ewart, S3
Arshad, H1
Karmaus, W1
Lipiec, A1
Wawrzyniak, ZM1
Sybilski, AJ1
Samolińska-Zawisza, U1
Krzych-Fałta, E1
Piekarska, B1
Dulny, G1
Stankiewicz-Choroszucha, B1
Raciborski, F1
Samoliński, B1
Chinratanapisit, S1
Suratannon, N1
Pacharn, P1
Sritipsukho, P1
Vichyanond, P1
Lacerda Ribeiro, MT1
Paes Porto, HK1
de Oliveira, DF1
da Silva Castro, PF1
Rocha, ML1
Kiernan, E1
Jones, KL1
Moral, L1
Torres-Borrego, J1
Korta Murua, J1
Valverde-Molina, J2
Pellegrini Belinchón, J1
Praena-Crespo, M1
Ortega Casanueva, C1
Callén-Blecua, MT1
Fernández-Llamazares, CM1
Calvo Rey, C1
Martinez-Gimeno, A1
Kang, SH1
Jung, YH2
Kim, HY2
Seo, JH2
Lee, JY1
Kwon, JW2
Kim, BJ2
Kim, HB2
Lee, SY2
Jang, GC1
Song, DJ1
Kim, WK1
Shim, JY1
Kim, JH1
Kang, MJ2
Yu, HS2
Yu, J1
Hong, SJ2
Osimani, B2
Selgrade, MK1
Blain, RB1
Fedak, KM1
Cawley, MA1
Muc, M1
Padez, C1
Pinto, AM1
Wang, JY1
Liu, LF1
Chen, CY1
Huang, YW1
Hsiung, CA1
Tsai, HJ1
Goldman, RD2
Murphy, R1
Stewart, AW3
Hancox, RJ1
Mitchell, EA5
Kim, H1
Johnson, CC2
Ioannides, SJ1
Williams, M1
Jefferies, S2
Perrin, K1
Siebers, R1
Crane, J7
Patel, M1
Travers, J1
Shirtcliffe, P2
Amberbir, A1
Medhin, G1
Hanlon, C1
Britton, J2
Davey, G3
Venn, A2
Habre, W1
Veyckemans, F1
Lee, SH1
Hong, K1
Kim, HJ1
Kim, YJ1
Kim, HS1
Park, KS1
Tiegs, G2
Karimi, K2
Brune, K2
Arck, P2
Ioannides, S1
Caswell-Smith, R1
Hunt, A2
Bowden, V1
Power, S1
Stanley, T2
Ingham, T2
Cheelo, M1
Simpson, JA1
Matheson, M1
Heinrich, J2
Sordillo, JE1
Scirica, CV1
Rifas-Shiman, SL1
Gillman, MW1
Bunyavanich, S1
Camargo, CA2
Weiss, ST1
Gold, DR1
Litonjua, AA2
Shaheen, SO10
Mignini, F1
Keßler, T1
Thiele, K1
Ramisch, K1
Erhardt, A1
Huebener, P1
Barikbin, R1
Liu, X1
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Pedersen, LH1
Bech, BH1
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Karlstad, Ø1
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Davey Smith, G1
Nystad, W1
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Thrall, RS1
Cloutier, MM1
Manautou, JE1
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Bacharier, LB1
Holguin, F1
Lemanske, RF1
Martinez, FD1
Pongracic, JA1
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Benson, M1
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den Dekker, HT1
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Sakulchit, T1
Del-Rio-Navarro, BE2
Ito-Tsuchiya, FM1
Berber, A2
Zepeda-Ortega, B2
Sienra-Monge, JJ2
Garcia-Almaraz, R1
Baeza-Bacab, M2
Shaheen, S1
Potts, J1
Gnatiuc, L1
Makowska, J1
Kowalski, ML1
Joos, G1
van Zele, T1
van Durme, Y1
De Rudder, I1
Wöhrl, S1
Godnic-Cvar, J1
Skadhauge, L2
Thomsen, G1
Zuberbier, T1
Bergmann, KC1
Heinzerling, L1
Gjomarkaj, M1
Bruno, A1
Pace, E1
Bonini, S1
Fokkens, W1
Weersink, EJ1
Loureiro, C1
Todo-Bom, A1
Villanueva, CM1
Sanjuas, C1
Zock, JP1
Janson, C1
Burney, P2
Barr, RG4
Clayton, T2
von Mutius, E1
Lai, CK2
Montefort, S1
Stewart, A2
Persky, V1
Piorkowski, J1
Hernandez, E1
Chavez, N1
Wagner-Cassanova, C1
Vergara, C1
Pelzel, D1
Enriquez, R1
Gutierrez, S1
Busso, A1
Thomsen, SF1
Kyvik, KO1
Steffensen, I1
Backer, V1
Sanchez-Solis, M2
Perez-Fernandez, V2
Pastor-Vivero, MD1
Mondejar-Lopez, P1
Lawrence, J1
Moore, E1
Port, L1
Danchin, M1
Connell, T1
Lowe, A1
Abramson, M1
Dharmage, S1
Allen, K1
Lawyer, AB1
Allmers, H2
Skudlik, C1
John, SM1
Autret-Leca, E1
Asher, MI1
Ellwood, P1
Mackay, R1
Moyes, C1
Pattemore, PK1
Pearce, N2
Etminan, M1
Sadatsafavi, M1
Jafari, S1
Doyle-Waters, M1
Aminzadeh, K1
FitzGerald, JM1
Becker, KG1
Schultz, ST1
Farquhar, H2
Eyers, S3
Perzanowski, MS1
Miller, RL1
Tang, D1
Ali, D1
Garfinkel, RS1
Chew, GL1
Goldstein, IF1
Perera, FP1
Singh, A1
Kang, EM1
Lundsberg, LS1
Illuzzi, JL1
Bracken, MB1
Hutson, S1
Tapiainen, T1
Dunder, T1
Möttönen, M1
Uhari, M1
Persky, VW1
Mitchell, E1
Sultész, M1
Katona, G1
Hirschberg, A1
Gálffy, G1
Newson, RB5
Smith, GD1
González-Díaz, C1
Garvajal-Urueña, I1
Pac-Sa, MR1
Busquets-Monge, RM1
Suárez-Varela, MM1
Batlles-Garrido, J1
Blanco-Quirós, A1
Varela, AL1
García-Hernández, G1
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Williams, P1
Matthews, S1
Roberts, G2
Hasan Arshad, S1
Grundy, JD1
Clayton, CB1
Mitchell, FA1
Sadeghnejad, A1
Arshad, SH1
Holt, PG1
Strickland, DH1
Sly, PD1
Pertega, S1
Perez Castro, T1
Sampedro, M1
Sanchez Lastres, J1
San Jose Gonzalez, MA1
Bamonde, L1
Garnelo, L1
Carreira, JM1
Moure, J1
Lopez Silvarrey, A1
Ward, J1
Bala, S1
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Szabo, G1
Soferman, R1
Tsivion, A1
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Kreiner-Møller, E1
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Vissing, NH1
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Golding, J1
Appelboam, AV1
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Knighton, J1
Namazy, JA1
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Kalyoncu, AF3
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Nuttall, SL2
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Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
As Needed Versus Regular Use of Intranasal Corticosteroid in Children With Perennial Allergic Rhinitis: A Randomized Controlled Trial[NCT05299086]68 participants (Anticipated)Interventional2022-04-04Recruiting
Acetaminophen vs. Ibuprofen in Children With Asthma[NCT01606319]Phase 3300 participants (Actual)Interventional2013-02-28Completed
Swiss Childhood Cancer Survivor Study (SCCSS)[NCT03297034]3,626 participants (Anticipated)Observational [Patient Registry]2007-01-01Recruiting
Oral Versus Intravenous Acetaminophen for Postoperative Pain Management After Oocyte Retrieval Procedure. A Double Blinded, Placebo Controlled, Randomized Clinical Trial[NCT04662567]42 participants (Actual)Interventional2021-03-12Terminated (stopped due to It was determined that the study should not continue as the study drug, Acetaminophen, could only be mixed in a solvent that would not allow the patients to be NPO prior to procedure.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Asthma Control Days

proportion of study days on which asthma was controlled, measured by electronic diary (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period

Interventionproportion of days (Mean)
Acetaminophen.86
Ibuprofen.87

Asthma Rescue Medication Use

average albuterol rescue use per week, measured by electronic diary (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period

Interventioninhalations per week (Mean)
Acetaminophen2.8
Ibuprofen3

Exacerbation Frequency

the number of asthma exacerbations requiring systemic corticosteroids (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period

Interventionasthma exacerbations per 46 weeks (Mean)
Acetaminophen0.81
Ibuprofen.87

Health Care Utilization

frequency of unscheduled physician visits, emergency department visits or hospitalizations for asthma (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period

Interventionunscheduled health visits per 46 weeks (Mean)
Acetaminophen.75
Ibuprofen.76

Reviews

41 reviews available for acetaminophen and Asthma, Bronchial

ArticleYear
Why paracetamol (acetaminophen) is a suitable first choice for treating mild to moderate acute pain in adults with liver, kidney or cardiovascular disease, gastrointestinal disorders, asthma, or who are older.
    Current medical research and opinion, 2022, Volume: 38, Issue:5

    Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics; Analgesics, Non-Narcotic; Asthma; Cardiovascular

2022
    Computational & theoretical chemistry, 2013, Feb-01, Volume: 1005

    Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am

2013
Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials.
    BMC pulmonary medicine, 2020, Mar-23, Volume: 20, Issue:1

    Topics: Acetaminophen; Asthma; Child; Disease Progression; Humans; Ibuprofen; Randomized Controlled Trials a

2020
Intrauterine Exposure to Acetaminophen and Adverse Developmental Outcomes: Epidemiological Findings and Methodological Issues.
    Current environmental health reports, 2021, Volume: 8, Issue:1

    Topics: Acetaminophen; Asthma; Child; Female; Humans; Pregnancy; Prenatal Exposure Delayed Effects

2021
Paracetamol exposure and asthma: What does the evidence say? An overview of systematic reviews.
    Pediatric pulmonology, 2021, Volume: 56, Issue:10

    Topics: Acetaminophen; Asthma; Female; Humans; Pregnancy; Risk; Systematic Reviews as Topic

2021
Long-term adverse effects of paracetamol - a review.
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:10

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Asthma; Cardiovascular Diseases; Chron

2018
Medications that Cause Fetal Anomalies and Possible Prevention Strategies.
    Clinics in perinatology, 2019, Volume: 46, Issue:2

    Topics: Abnormalities, Drug-Induced; Acetaminophen; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Analg

2019
The association between acetaminophen and asthma: should its pediatric use be banned?
    Expert review of respiratory medicine, 2013, Volume: 7, Issue:2

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Asthma; Evidence-Based Medicine; Humans; Preva

2013
Potential risk of asthma associated with in utero exposure to xenobiotics.
    Birth defects research. Part C, Embryo today : reviews, 2013, Volume: 99, Issue:1

    Topics: Acetaminophen; Adult; Animals; Asthma; Child; Environmental Exposure; Female; Humans; Mice; Pregnanc

2013
The association between acetaminophen and asthma: is there anything to learn from the upper airways?
    Current opinion in allergy and clinical immunology, 2014, Volume: 14, Issue:1

    Topics: Acetaminophen; Anti-Bacterial Agents; Asthma; Cohort Studies; Confounding Factors, Epidemiologic; Fe

2014
New problems arising from old drugs: second-generation effects of acetaminophen.
    Expert review of clinical pharmacology, 2014, Volume: 7, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Asthma; Chemical and Drug Induced Liver Injury; Ch

2014
The association between paracetamol use and asthma: causation or coincidence?
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2015, Volume: 45, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Asthma; Child; Child, Preschool; Female;

2015
Paracetamol exposure in pregnancy and early childhood and development of childhood asthma: a systematic review and meta-analysis.
    Archives of disease in childhood, 2015, Volume: 100, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child, Preschool; Female; Humans; Infant; Pregnancy

2015
The association between paracetamol and asthma is still under debate.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2017, 01-02, Volume: 54, Issue:1

    Topics: Acetaminophen; Asthma; Child, Preschool; Female; Glutathione; Humans; Infant; Infant, Newborn; Perox

2017
Acetaminophen use and asthma in children.
    Canadian family physician Medecin de famille canadien, 2017, Volume: 63, Issue:3

    Topics: Acetaminophen; Age Factors; Antipyretics; Asthma; Child; Child, Preschool; Disease Progression; Dose

2017
Acetaminophen use: a risk for asthma?
    Current allergy and asthma reports, 2009, Volume: 9, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Female; Humans; Male; Prevalence

2009
Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis.
    Chest, 2009, Volume: 136, Issue:5

    Topics: Acetaminophen; Adult; Antioxidants; Asthma; Child; Humans; Meta-Analysis as Topic

2009
The role of paracetamol in the pathogenesis of asthma.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2010, Volume: 40, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asthma; Child; Child, Preschool; Female; Global Heal

2010
Childhood asthma and use during pregnancy of acetaminophen. A critical review.
    Reproductive toxicology (Elmsford, N.Y.), 2010, Volume: 30, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipyretics; Asthma; Child; Child, Preschool; Confounding

2010
Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta-analysis.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2011, Volume: 41, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child; Female; Humans; Pregnancy; Prenatal Exposure

2011
Early exposure to acetaminophen and allergic disorders.
    Current opinion in allergy and clinical immunology, 2011, Volume: 11, Issue:3

    Topics: Acetaminophen; Asthma; Drug Hypersensitivity; Female; Humans; Maternal Exposure; Pregnancy; Prenatal

2011
Paracetamol and cyclooxygenase inhibition: is there a cause for concern?
    Annals of the rheumatic diseases, 2012, Volume: 71, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Blood Plat

2012
Virus infection and allergy in the development of asthma: what is the connection?
    Current opinion in allergy and clinical immunology, 2012, Volume: 12, Issue:2

    Topics: Acetaminophen; Asthma; Bacterial Infections; Humans; Hypersensitivity; Interleukin-15; Respiratory T

2012
The case of drug causation of childhood asthma: antibiotics and paracetamol.
    European journal of clinical pharmacology, 2013, Volume: 69, Issue:6

    Topics: Acetaminophen; Age of Onset; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Asthma; Child; Child,

2013
Acetaminophen and asthma.
    Paediatric respiratory reviews, 2013, Volume: 14, Issue:1

    Topics: Acetaminophen; Antipyretics; Asthma; Female; Global Health; Humans; Incidence; Pregnancy; Prenatal E

2013
Sensitivity to nonsteroidal anti-inflammatory drugs.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 89, Issue:6

    Topics: Acetaminophen; Adult; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Bleedin

2002
Paracetamol and asthma.
    Expert opinion on pharmacotherapy, 2003, Volume: 4, Issue:1

    Topics: Acetaminophen; Asthma; Drug Interactions; Humans

2003
The safety of ibuprofen suspension in children.
    International journal of clinical practice. Supplement, 2003, Issue:135

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Fev

2003
Does paracetamol cause asthma?
    Journal of clinical pharmacy and therapeutics, 2003, Volume: 28, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Asthma; Female; Free Radicals; Glutathione; Humans

2003
[Drug therapy in pregnancy--a practical guide].
    MMW Fortschritte der Medizin, 2004, Mar-11, Volume: 146, Issue:11

    Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Bacte

2004
Acetaminophen and the risk of asthma: the epidemiologic and pathophysiologic evidence.
    Chest, 2005, Volume: 127, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Cohort Studies; Cross-Sectional Studies; Forced Exp

2005
Paracetamol, antioxidants and asthma.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2005, Volume: 35, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Asthma; Environmental Exposure; Genotype; Hum

2005
Frequent acetaminophen use and allergic diseases: is the association clear?
    The Journal of allergy and clinical immunology, 2005, Volume: 116, Issue:4

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Female; Humans; Hypersensit

2005
A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms.
    Clinical therapeutics, 2007, Volume: 29, Issue:12

    Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Asthma; Child; Fever; Hospitalization; Humans;

2007
Ibuprofen and asthma in paediatric populations: clinical concern or clinical reality?
    Journal of the Royal Society of Medicine, 2007, Volume: 100 Suppl 48

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Cyclooxygenase Inhibitors; Hu

2007
Analgesic-antipyretic choices for children with asthma: a review of safety and risk of common preparations.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 1984, Volume: 21, Issue:5

    Topics: Acetaminophen; Adolescent; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Br

1984
Recommending analgesics for people with asthma.
    American journal of therapeutics, 2000, Volume: 7, Issue:2

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Humans

2000
The use of analgesics in patients with asthma.
    Drug safety, 2001, Volume: 24, Issue:11

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspiri

2001
Effective use of analgesic drugs.
    Annual review of medicine, 1976, Volume: 27

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ast

1976
Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma.
    The Journal of allergy and clinical immunology, 1989, Volume: 84, Issue:1

    Topics: Acetaminophen; Adult; Aged; Aspirin; Asthma; Desensitization, Immunologic; Double-Blind Method; Drug

1989
The pathogenesis of asthma.
    The Medical clinics of North America, 1974, Volume: 58, Issue:1

    Topics: Acetaminophen; Adult; Affective Symptoms; Air Pollution; Aspirin; Asthma; Autonomic Nervous System;

1974

Trials

18 trials available for acetaminophen and Asthma, Bronchial

ArticleYear
Panic or peace - prioritising infant welfare when medicating feverish infants: a grounded theory study of adherence in a paediatric clinical trial.
    BMC pediatrics, 2022, 04-11, Volume: 22, Issue:1

    Topics: Acetaminophen; Asthma; Fever; Grounded Theory; Humans; Ibuprofen; Infant; Infant Welfare

2022
    Computational & theoretical chemistry, 2013, Feb-01, Volume: 1005

    Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am

2013
Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol.
    BMJ open, 2020, 12-10, Volume: 10, Issue:12

    Topics: Acetaminophen; Asthma; Child; Child, Preschool; Humans; Ibuprofen; Infant; Infant, Newborn; Multicen

2020
Adherence rates during a randomized controlled trial evaluating the use of blinded acetaminophen and ibuprofen in children with asthma.
    Contemporary clinical trials, 2021, Volume: 104

    Topics: Acetaminophen; Asthma; Child; Double-Blind Method; Humans; Ibuprofen

2021
Glutathione and arginine levels: Predictors for acetaminophen-associated asthma exacerbation?
    The Journal of allergy and clinical immunology, 2018, Volume: 142, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Asthmatic Agents; Arginine; Asthma; Biomarkers; Child,

2018
[In process].
    Medizinische Monatsschrift fur Pharmazeuten, 2016, Volume: 39, Issue:10

    Topics: Acetaminophen; Asthma; Child, Preschool; Disease Progression; Fever; Humans; Ibuprofen; Pain; Prospe

2016
Randomised placebo-controlled study of the effect of paracetamol on asthma severity in adults.
    BMJ open, 2014, Feb-12, Volume: 4, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asthma; Breath Tests; Bronchial Hyperreactivity; Bro

2014
Randomized controlled trial of asthma risk with paracetamol use in infancy--a feasibility study.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2015, Volume: 45, Issue:2

    Topics: Acetaminophen; Adult; Age Factors; Asthma; Feasibility Studies; Female; Humans; Infant; Infant, Newb

2015
Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma.
    The New England journal of medicine, 2016, Aug-18, Volume: 375, Issue:7

    Topics: Acetaminophen; Asthma; Child, Preschool; Double-Blind Method; Female; Fever; Humans; Ibuprofen; Inci

2016
Pilot study of feasibility of a randomised controlled trial of asthma risk with paracetamol versus ibuprofen use in infancy.
    The New Zealand medical journal, 2016, Oct-14, Volume: 129, Issue:1443

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Female; Humans; Ibuprofen; Infant; Infant, Newborn;

2016
The effect of a single dose of acetaminophen on airways response in children with asthma.
    Clinical pediatrics, 2013, Volume: 52, Issue:1

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Asthma; Bronchi; Bronchial Hyperreactivity; Bro

2013
Adverse pulmonary responses to aspirin and acetaminophen in chronic childhood asthma.
    Pediatrics, 1983, Volume: 71, Issue:3

    Topics: Acetaminophen; Adolescent; Aspirin; Asthma; Child; Double-Blind Method; Female; Forced Expiratory Vo

1983
Prevalence of cross-sensitivity with acetaminophen in aspirin-sensitive asthmatic subjects.
    The Journal of allergy and clinical immunology, 1995, Volume: 96, Issue:4

    Topics: Acetaminophen; Adult; Aged; Aspirin; Asthma; Cross Reactions; Dose-Response Relationship, Immunologi

1995
The safety of acetaminophen and ibuprofen among children younger than two years old.
    Pediatrics, 1999, Volume: 104, Issue:4

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Asthma; Bronchiolitis; Double-Blind Method;

1999
Asthma morbidity after the short-term use of ibuprofen in children.
    Pediatrics, 2002, Volume: 109, Issue:2

    Topics: Acetaminophen; Age Factors; Ambulatory Care; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non

2002
Analgesic sensitivity in children with asthma.
    Pediatrics, 1978, Volume: 62, Issue:5 Pt 2 Sup

    Topics: Acetaminophen; Adolescent; Airway Obstruction; Analgesics; Aspirin; Asthma; Child; Clinical Trials a

1978
Salsalate cross-sensitivity in aspirin-sensitive patients with asthma.
    The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:5

    Topics: Acetaminophen; Administration, Oral; Aspirin; Asthma; Double-Blind Method; Drug Hypersensitivity; Fo

1990
Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma.
    The Journal of allergy and clinical immunology, 1989, Volume: 84, Issue:1

    Topics: Acetaminophen; Adult; Aged; Aspirin; Asthma; Desensitization, Immunologic; Double-Blind Method; Drug

1989

Other Studies

142 other studies available for acetaminophen and Asthma, Bronchial

ArticleYear
Prenatal Exposure to Acetaminophen and Childhood Asthmatic Symptoms in a Population-Based Cohort in Los Angeles, California.
    International journal of environmental research and public health, 2021, 09-26, Volume: 18, Issue:19

    Topics: Acetaminophen; Asthma; Child; Female; Humans; Los Angeles; Pregnancy; Prenatal Exposure Delayed Effe

2021
The role of Human Development Index in the epidemiology of asthma in adolescents in Kosovo: A cross-sectional multicentre Global Asthma Network (GAN) study.
    Allergologia et immunopathologia, 2023, Volume: 51, Issue:2

    Topics: Acetaminophen; Adolescent; Animals; Asthma; Cross-Sectional Studies; Dogs; Humans; Kosovo; Prevalenc

2023
Factors associated with allergic rhinitis and combined allergic rhinitis and asthma syndrome (CARAS) in adults undergoing immunotherapy in a tropical country: Is ISAAC-III questionnaire useful in adult populations?
    Allergologia et immunopathologia, 2023, Volume: 51, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Aged; Allergens; Animals; Asthma; Cross-Sectional Studies; Dogs; F

2023
Impact of antipyretics on acute asthma exacerbation during respiratory infection-A nationwide population-based study.
    Pediatrics and neonatology, 2020, Volume: 61, Issue:5

    Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Asthma; Child; Chi

2020
Impact of the COVID-19 pandemic in children with allergic asthma.
    The journal of allergy and clinical immunology. In practice, 2020, Volume: 8, Issue:9

    Topics: Acetaminophen; Adolescent; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Analgesics,

2020
Intravenous paracetamol for neonates: long-term diseases not escalated during 5 years of follow-up.
    Archives of disease in childhood. Fetal and neonatal edition, 2021, Volume: 106, Issue:2

    Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Apgar Score; Asthma; Birth Wei

2021
Acetaminophen and asthma, a bitter pill to swallow?
    The Journal of allergy and clinical immunology, 2020, Volume: 146, Issue:5

    Topics: Acetaminophen; Adolescent; Asthma; Glutathione Transferase; Humans; Taste

2020
Prevalence of asthma and allergies in 13-14-year-old adolescents from Luanda, Angola.
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2017, 06-01, Volume: 21, Issue:6

    Topics: Acetaminophen; Adolescent; Angola; Asthma; Cross-Sectional Studies; Eczema; Female; Humans; Hypersen

2017
Risk Factors Associated with Asthma Development and Control in Children. Mouse Infestation, Antipyretics, Respiratory Viruses, and Allergic Sensitization.
    American journal of respiratory and critical care medicine, 2017, 12-15, Volume: 196, Issue:12

    Topics: Acetaminophen; Allergens; Animals; Antipyretics; Asthma; Child; Humans; Hypersensitivity; Ibuprofen;

2017
Conjugation of nitrated acetaminophen to Der p1 amplifies peripheral blood monocyte response to Der p1.
    PloS one, 2017, Volume: 12, Issue:12

    Topics: Acetaminophen; Animals; Antigens, Dermatophagoides; Arthropod Proteins; Asthma; Cysteine Endopeptida

2017
Role of combined prenatal and postnatal paracetamol exposure on asthma development: the Czech ELSPAC study.
    Journal of epidemiology and community health, 2018, Volume: 72, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child, Preschool; Czech Republic; Female; Humans; I

2018
Leptin receptor gene polymorphisms and sex modify the association between acetaminophen use and asthma among young adults: results from two observational studies.
    Respiratory research, 2018, Sep-19, Volume: 19, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Asthma; Cohort Studies; Cross-Sectional

2018
The association between paracetamol use and the risk of asthma, rhinitis and eczema in the Polish population.
    Annals of agricultural and environmental medicine : AAEM, 2018, Sep-25, Volume: 25, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Asthma; Child; Eczema; Female; Humans; M

2018
Prevalence and risk factors of allergic rhinitis in children in Bangkok area.
    Asian Pacific journal of allergy and immunology, 2019, Volume: 37, Issue:4

    Topics: Acetaminophen; Adolescent; Air Pollution; Animals; Asthma; Child; Cross-Sectional Studies; Eczema; F

2019
Treatment with Paracetamol is not Associated with Increased Airway Sensitivity and Risk of Asthma in Rats.
    Current drug safety, 2019, Volume: 14, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Asthma; Carbachol; Glutat

2019
Asthma: looking beyond the headlines.
    The Lancet. Respiratory medicine, 2019, Volume: 7, Issue:5

    Topics: Acetaminophen; Air Pollutants; Asthma; Humans; Risk Factors; Vitamin D

2019
[Association between paracetamol exposure and asthma: update and practice guidelines].
    Anales de pediatria (Barcelona, Spain : 2003), 2013, Volume: 79, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipyretics; Asthma; Child; Humans

2013
Effect of paracetamol use on the modification of the development of asthma by reactive oxygen species genes.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2013, Volume: 110, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Arylamine N-Acetyltransferase; Asthma; Child; Child, Presch

2013
Until RCT proven? On the asymmetry of evidence requirements for risk assessment.
    Journal of evaluation in clinical practice, 2013, Volume: 19, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Data Interpretation, Statistical; Drug-Related Side

2013
Exposure to paracetamol and antibiotics in early life and elevated risk of asthma in childhood.
    Advances in experimental medicine and biology, 2013, Volume: 788

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Asthma; Child; Cross-Sectional Studi

2013
Acetaminophen and/or antibiotic use in early life and the development of childhood allergic diseases.
    International journal of epidemiology, 2013, Volume: 42, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Asthma; Child; Child, Preschool; Der

2013
Acetaminophen in children: an old drug with new warnings.
    Canadian family physician Medecin de famille canadien, 2013, Volume: 59, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child; Drug Approval; Drug Eruptions; Humans; Unite

2013
Antibiotic treatment during infancy and increased body mass index in boys: an international cross-sectional study.
    International journal of obesity (2005), 2014, Volume: 38, Issue:8

    Topics: Acetaminophen; Anti-Bacterial Agents; Asthma; Body Mass Index; Breast Feeding; Child; Child, Prescho

2014
Effects of early life paracetamol use on the incidence of allergic disease and sensitization: 5 year follow-up of an Ethiopian birth cohort.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Acetaminophen; Age of Onset; Asthma; Child, Preschool; Cohort Studies; Cross-Sectional Studies; Deve

2014
Do not add to the stress: is paracetamol prescription well tolerated by children?
    European journal of anaesthesiology, 2014, Volume: 31, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthesia; Asthma; Child; Humans

2014
Association between recent acetaminophen use and asthma: modification by polymorphism at TLR4.
    Journal of Korean medical science, 2014, Volume: 29, Issue:5

    Topics: Acetaminophen; Adolescent; Asthma; Bronchial Hyperreactivity; Child; Cross-Sectional Studies; Eosino

2014
Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children.
    The Journal of allergy and clinical immunology, 2015, Volume: 135, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chi

2015
Acetaminophen and childhood asthma: pill-popping at our peril?
    The Journal of allergy and clinical immunology, 2015, Volume: 135, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Female; Hu

2015
Causal assessment of pharmaceutical treatments: why standards of evidence should not be the same for benefits and harms?
    Drug safety, 2015, Volume: 38, Issue:1

    Topics: Acetaminophen; Asthma; Bayes Theorem; Causality; Drug-Related Side Effects and Adverse Reactions; Hu

2015
Prenatal acetaminophen induces liver toxicity in dams, reduces fetal liver stem cells, and increases airway inflammation in adult offspring.
    Journal of hepatology, 2015, Volume: 62, Issue:5

    Topics: Acetaminophen; Adult; Adult Children; Analgesics, Non-Narcotic; Animals; Asthma; Chemical and Drug I

2015
Association of prenatal exposure to acetaminophen and coffee with childhood asthma.
    Pharmacoepidemiology and drug safety, 2016, Volume: 25, Issue:2

    Topics: Acetaminophen; Adult; Asthma; Coffee; Cohort Studies; Denmark; Female; Follow-Up Studies; Humans; Pr

2016
Prenatal and infant paracetamol exposure and development of asthma: the Norwegian Mother and Child Cohort Study.
    International journal of epidemiology, 2016, Volume: 45, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child, Preschool; Cohort Studies; Female; Humans; I

2016
Paracetamol exposure prenatally and in infancy is linked to asthma, study shows.
    BMJ (Clinical research ed.), 2016, Feb-11, Volume: 352

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Humans; Prenatal Exposure Delayed Effects

2016
Acetaminophen Attenuates House Dust Mite-Induced Allergic Airway Disease in Mice.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 358, Issue:3

    Topics: Acetaminophen; Animals; Asthma; Cytochrome P-450 Enzyme System; Cytokines; Dose-Response Relationshi

2016
Acetaminophen and Asthma--A Small Sigh of Relief?
    The New England journal of medicine, 2016, Aug-18, Volume: 375, Issue:7

    Topics: Acetaminophen; Asthma; Humans

2016
Paracetamol is no more likely to exacerbate asthma in children than ibuprofen, shows study.
    BMJ (Clinical research ed.), 2016, 08-17, Volume: 354

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Fev

2016
Paracetamol no worse than ibuprofen in children with mild asthma.
    The Lancet. Respiratory medicine, 2016, Volume: 4, Issue:10

    Topics: Acetaminophen; Asthma; Child; Child, Preschool; Disease Progression; Female; Humans; Ibuprofen; Male

2016
TRPA1 gene polymorphisms and childhood asthma.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2017, Volume: 28, Issue:2

    Topics: Acetaminophen; Asthma; Child, Preschool; Cohort Studies; Female; Follow-Up Studies; Genetic Associat

2017
Association of Acetaminophen and Ibuprofen Use With Wheezing in Children With Acute Febrile Illness.
    The Annals of pharmacotherapy, 2017, Volume: 51, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipyretics; Asthma; Child; Child, Preschool; Cross-Sectio

2017
Acetaminophen versus Ibuprofen in Mild Persistent Asthma.
    The New England journal of medicine, 2016, 11-24, Volume: 375, Issue:21

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Double-Blind Method; Fever; Humans;

2016
Acetaminophen versus Ibuprofen in Mild Persistent Asthma.
    The New England journal of medicine, 2016, 11-24, Volume: 375, Issue:21

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Double-Blind Method; Fever; Humans;

2016
Study of the relationship between acetaminophen and asthma in Mexican children aged 6 to 7 years in 3 Mexican cities using ISAAC methodology.
    Journal of investigational allergology & clinical immunology, 2008, Volume: 18, Issue:3

    Topics: Acetaminophen; Asthma; Child; Cross-Sectional Studies; Female; Humans; Male; Mexico; Urban Health

2008
The relation between paracetamol use and asthma: a GA2LEN European case-control study.
    The European respiratory journal, 2008, Volume: 32, Issue:5

    Topics: Acetaminophen; Adult; Analgesics; Asthma; Case-Control Studies; Europe; Female; Humans; Male; Middle

2008
Does paracetamol cause asthma in children? Time to remove the guesswork.
    Lancet (London, England), 2008, Sep-20, Volume: 372, Issue:9643

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asthma; Child; Female; Humans; Infant; Male; Randomi

2008
Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme.
    Lancet (London, England), 2008, Sep-20, Volume: 372, Issue:9643

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Asthma; Child; Conjunctivitis; Cross-Sectional

2008
Prenatal exposure to acetaminophen and respiratory symptoms in the first year of life.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2008, Volume: 101, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Asthma; Breast Feeding; Cough; Female; H

2008
Intake of paracetamol and risk of asthma in adults.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2008, Volume: 45, Issue:8

    Topics: Acetaminophen; Adolescent; Adult; Asthma; Child; Denmark; Female; Humans; Male; Prevalence; Prospect

2008
Is the effect of prenatal paracetamol exposure on wheezing in preschool children modified by asthma in the mother?
    International archives of allergy and immunology, 2009, Volume: 149, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child, Preschool; Female; Humans; Male; Mothers; Pr

2009
Paracetamol as a risk factor for allergic disorders.
    Lancet (London, England), 2009, Jan-10, Volume: 373, Issue:9658

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Bias; Child; Humans; Infant; Infant, Newborn; Risk

2009
Paracetamol as a risk factor for allergic disorders.
    Lancet (London, England), 2009, Jan-10, Volume: 373, Issue:9658

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Bias; Child; Confounding Factors, Epidemiologic; Hu

2009
Paracetamol as a risk factor for allergic disorders.
    Lancet (London, England), 2009, Jan-10, Volume: 373, Issue:9658

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Bias; Child; Humans; Infant; Infant, Newborn; Menta

2009
Paracetamol as a risk factor for allergic disorders.
    Lancet (London, England), 2009, Jan-10, Volume: 373, Issue:9658

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Humans; Logistic Models; Organic Chemicals; Structu

2009
[Drugs news].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2009, Volume: 16, Issue:5

    Topics: Acetaminophen; Acupuncture; Asthma; Child; Glucocorticoids; Hemorrhage; Humans; Placebo Effect; Resp

2009
Cross-sectional survey of risk factors for asthma in 6-7-year-old children in New Zealand: International Study of Asthma and Allergy in Childhood Phase Three.
    Journal of paediatrics and child health, 2009, Volume: 45, Issue:6

    Topics: Acetaminophen; Air Pollutants; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Asthma; Child; Cross

2009
Similarities in features of autism and asthma and a possible link to acetaminophen use.
    Medical hypotheses, 2010, Volume: 74, Issue:1

    Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Autistic Disorder; Child

2010
The acetaminophen and asthma hypothesis 10 years on: A case to answer.
    The Journal of allergy and clinical immunology, 2009, Volume: 124, Issue:4

    Topics: Acetaminophen; Asthma; Clinical Trials as Topic; Humans; Risk Factors

2009
Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort.
    Thorax, 2010, Volume: 65, Issue:2

    Topics: Acetaminophen; Allergens; Analgesics, Non-Narcotic; Asthma; Child, Preschool; Female; Genetic Predis

2010
Acetaminophen and asthma.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2009, Oct-27, Volume: 181, Issue:9

    Topics: Acetaminophen; Age Factors; Asthma; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Inci

2009
Prenatal exposure to acetaminophen and asthma in children.
    Obstetrics and gynecology, 2009, Volume: 114, Issue:6

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asthma; Child; Female; Humans; Pregnancy; Prenatal E

2009
Painkiller concerns grow ahead of new guidelines.
    Nature medicine, 2010, Volume: 16, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child; Drug Labeling; Humans; United States; United

2010
Adolescents with asthma or atopic eczema have more febrile days in early childhood: a possible explanation for the connection between paracetamol and asthma?
    The Journal of allergy and clinical immunology, 2010, Volume: 125, Issue:3

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Asthma; Child; Dermatitis, Atopic; Fever; Human

2010
Acetaminophen and asthma.
    Thorax, 2010, Volume: 65, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child; Female; Humans; Maternal-Fetal Exchange; Pre

2010
Prevalence and risk factors for allergic rhinitis in primary schoolchildren in Budapest.
    International journal of pediatric otorhinolaryngology, 2010, Volume: 74, Issue:5

    Topics: Acetaminophen; Adenoidectomy; Air Pollution; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Asthma

2010
Prenatal paracetamol exposure and asthma: further evidence against confounding.
    International journal of epidemiology, 2010, Volume: 39, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child; Confounding Factors, Epidemiologic; Female;

2010
Early exposure to paracetamol or to antibiotics and eczema at school age: modification by asthma and rhinoconjunctivitis.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2010, Volume: 21, Issue:7

    Topics: Acetaminophen; Anti-Bacterial Agents; Asthma; Child; Conjunctivitis; Eczema; Family; Female; Humans;

2010
Disparate geographic prevalences of asthma, allergic rhinoconjunctivitis and atopic eczema among adolescents in five Canadian cities.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2010, Volume: 21, Issue:5

    Topics: Acetaminophen; Adolescent; Asian People; Asthma; Child; Conjunctivitis, Allergic; Dermatitis, Atopic

2010
Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International Study of Asthma and Allergies in Childhood Phase Three.
    American journal of respiratory and critical care medicine, 2011, Jan-15, Volume: 183, Issue:2

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Asthma; Causality; Cohort Studies; Conjunctivit

2011
Paracetamol – accumulating reports of an association with allergy and asthma.
    Acta paediatrica (Oslo, Norway : 1992), 2011, Volume: 100, Issue:1

    Topics: Acetaminophen; Antipyretics; Asthma; Child; Female; Humans; Hypersensitivity; Infant; Pregnancy; Pre

2011
Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, Volume: 24, Issue:12

    Topics: Acetaminophen; Acrolein; Analgesics, Non-Narcotic; Animals; Asthma; Benzoquinones; Bronchoalveolar L

2010
Paracetamol use in early life and asthma: prospective birth cohort study.
    BMJ (Clinical research ed.), 2010, Sep-15, Volume: 341

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child; Child, Preschool; Eczema; Humans; Infant; In

2010
The effects of early and late paracetamol exposure on asthma and atopy: a birth cohort.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2011, Volume: 41, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child; Child, Preschool; Cohort Studies; Female; Hu

2011
Respiratory tract infections and not paracetamol medication during infancy are associated with asthma development in childhood.
    The Journal of allergy and clinical immunology, 2010, Volume: 126, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child; Child, Preschool; Fever; Humans; Infant; Inf

2010
Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma.
    The Journal of allergy and clinical immunology, 2010, Volume: 126, Issue:6

    Topics: Acetaminophen; Asthma; Female; Genotype; Glutathione Transferase; Humans; Inactivation, Metabolic; I

2010
Paracetamol, nonsteroidal anti-inflammatory drugs, and risk of asthma in adult survivors of childhood cancer.
    The Journal of allergy and clinical immunology, 2011, Volume: 127, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child

2011
Paracetamol in early infancy: the risk of childhood allergy and asthma.
    Acta paediatrica (Oslo, Norway : 1992), 2011, Volume: 100, Issue:1

    Topics: Acetaminophen; Asthma; Child; Female; Follow-Up Studies; Humans; Hypersensitivity; Infant; Male; Pre

2011
The acetaminophen enigma in asthma.
    American journal of respiratory and critical care medicine, 2011, Jan-15, Volume: 183, Issue:2

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Asthma; Child; Humans

2011
Paracetamol and asthma and lactation.
    Acta paediatrica (Oslo, Norway : 1992), 2011, Volume: 100, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Breast Feeding; Female; Humans; Infant; Infant, New

2011
Paracetamol and antibiotics in childhood and subsequent development of wheezing/asthma: association or causation?
    International journal of epidemiology, 2011, Volume: 40, Issue:3

    Topics: Acetaminophen; Adolescent; Age Distribution; Age of Onset; Anti-Bacterial Agents; Asthma; Child; Cro

2011
Have the efforts to prevent aspirin-related Reye's syndrome fuelled an increase in asthma?
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2011, Volume: 41, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; H

2011
Does regular paracetamol ingestion increase the risk of developing asthma?
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2011, Volume: 41, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child; Female; Humans; Meta-Analysis as Topic; Preg

2011
Paracetamol use for non-respiratory indications and subsequent asthma: a valuable way to eliminate confounding by respiratory infections.
    International journal of epidemiology, 2011, Volume: 40, Issue:5

    Topics: Acetaminophen; Anti-Bacterial Agents; Asthma; Female; Humans; Male; Respiratory Sounds

2011
Commentary: Paracetamol and asthma--lessons from the antibiotic hypothesis?
    International journal of epidemiology, 2011, Volume: 40, Issue:3

    Topics: Acetaminophen; Anti-Bacterial Agents; Asthma; Female; Humans; Male; Respiratory Sounds

2011
Acetaminophen and asthma: spurious association?
    American journal of respiratory and critical care medicine, 2011, Jun-01, Volume: 183, Issue:11

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Bias; Child, Preschool; Dose-Response Relationship,

2011
Paracetamol and asthma: the case to date.
    Australian nursing journal (July 1993), 2011, Volume: 19, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Australia; Child; Child, Preschool; Humans; Infant;

2011
The association of acetaminophen and asthma prevalence and severity.
    Pediatrics, 2011, Volume: 128, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Asthma; Child; Humans; Prevalence; Sever

2011
Characterisation of asthma that develops during adolescence; findings from the Isle of Wight Birth Cohort.
    Respiratory medicine, 2012, Volume: 106, Issue:3

    Topics: Acetaminophen; Adolescent; Age Factors; Age of Onset; Analgesics, Non-Narcotic; Asthma; Bronchial Hy

2012
What does adolescent undiagnosed wheeze represent? Findings from the Isle of Wight Cohort.
    The European respiratory journal, 2012, Volume: 40, Issue:3

    Topics: Acetaminophen; Adolescent; Antipyretics; Asthma; Child; Child, Preschool; Cohort Studies; Female; He

2012
Exposure to paracetamol and asthma symptoms.
    European journal of public health, 2013, Volume: 23, Issue:4

    Topics: Acetaminophen; Adolescent; Age Factors; Analgesics, Non-Narcotic; Animals; Asthma; Cats; Child; Cros

2013
Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: a research study.
    World journal of gastroenterology, 2012, Jun-14, Volume: 18, Issue:22

    Topics: Acetaminophen; Alanine Transaminase; Animals; Asthma; Chemical and Drug Induced Liver Injury; Diseas

2012
Paracetamol exposure in utero or during infancy: no increase in asthma.
    Prescrire international, 2012, Volume: 21, Issue:129

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Female; Fetus; Humans; Pregnancy

2012
Infant acetaminophen use associates with early asthmatic symptoms independently of respiratory tract infections: the Copenhagen Prospective Study on Asthma in Childhood 2000 (COPSAC(2000)) cohort.
    The Journal of allergy and clinical immunology, 2012, Volume: 130, Issue:6

    Topics: Acetaminophen; Asthma; Child; Child, Preschool; Cohort Studies; Denmark; Female; Follow-Up Studies;

2012
Prescription-acquired acetaminophen use and the risk of asthma in adults: a case-control study.
    The Annals of pharmacotherapy, 2012, Volume: 46, Issue:12

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asthma; Case-Control Studies; Dose-Response Relation

2012
Pediatric emergency medicine: legal briefs.
    Pediatric emergency care, 2012, Volume: 28, Issue:12

    Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aortic Aneurysm; Aortic Dissection; Appendicitis;

2012
Maternal drug use during pregnancy and asthma risk among children.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2013, Volume: 24, Issue:1

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Child; Child

2013
Paracetamol use in pregnancy and wheezing in early childhood.
    Thorax, 2002, Volume: 57, Issue:11

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Asthma; Eczema; Female; Humans; Infant; Longitudin

2002
Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients with asthma.
    Emergency medicine journal : EMJ, 2002, Volume: 19, Issue:6

    Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Asthma; Fata

2002
Pain relievers and asthma.
    Pediatrics, 2003, Volume: 112, Issue:6 Pt 1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child; Humans; Ibuprofen; Morbidity; Risk

2003
Prospective study of acetaminophen use and newly diagnosed asthma among women.
    American journal of respiratory and critical care medicine, 2004, Apr-01, Volume: 169, Issue:7

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asthma; Female; Humans; Incidence; Middle Aged; Mult

2004
The flow-cytometric determination of basophil activation induced by aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is useful for in vitro diagnosis of the NSAID hypersensitivity syndrome.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2004, Volume: 34, Issue:9

    Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Basophil Degra

2004
Infections, medication use, and the prevalence of symptoms of asthma, rhinitis, and eczema in childhood.
    Journal of epidemiology and community health, 2004, Volume: 58, Issue:10

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Asthma; Child; Child, P

2004
Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2005, Volume: 35, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; As

2005
Emergent asthma: endogenous, exogenous, or iatrogenous.
    Chest, 2005, Volume: 127, Issue:2

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Child, Preschool; Cross-Secti

2005
The association of acetaminophen, aspirin, and ibuprofen with respiratory disease and lung function.
    American journal of respiratory and critical care medicine, 2005, May-01, Volume: 171, Issue:9

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asthma; Cross-Sectional Studies; Dose-Response Relat

2005
Use of acetaminophen and the risk of self-reported allergic symptoms and skin sensitization in Butajira, Ethiopia.
    The Journal of allergy and clinical immunology, 2005, Volume: 116, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Allergens; Animals; Anti-Inflammatory Age

2005
Early presentation with angioedema and urticaria in cross-reactive hypersensitivity to nonsteroidal antiinflammatory drugs among young, Asian, atopic children.
    Pediatrics, 2005, Volume: 116, Issue:5

    Topics: Acetaminophen; Administration, Oral; Adolescent; Allergens; Angioedema; Anti-Inflammatory Agents, No

2005
Asthma attacks induced by low doses of celecoxib, aspirin, and acetaminophen.
    The Journal of allergy and clinical immunology, 2006, Volume: 117, Issue:1

    Topics: Acetaminophen; Aspirin; Asthma; Celecoxib; Cyclooxygenase Inhibitors; Female; Humans; Leukotriene E4

2006
Acetaminophen use and the symptoms of asthma, allergic rhinitis and eczema in children.
    Iranian journal of allergy, asthma, and immunology, 2006, Volume: 5, Issue:2

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Asthma; Child; Dose-Response Relationship, Drug

2006
A matched patient-sibling study on the usage of paracetamol and the subsequent development of allergy and asthma.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2007, Volume: 18, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child; Child, Preschool; Female; Fetus; Humans; Hyp

2007
Environmental and socio-demographic factors associated to asthma in adolescents in Rio de Janeiro, Brazil.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2007, Volume: 18, Issue:2

    Topics: Acetaminophen; Adolescent; Animals; Animals, Domestic; Asthma; Brazil; Cats; Cross-Sectional Studies

2007
Factors associated with allergic rhinitis in children from northern Mexico City.
    Journal of investigational allergology & clinical immunology, 2007, Volume: 17, Issue:2

    Topics: Acetaminophen; Adolescent; Asthma; Child; Cross-Sectional Studies; Dermatitis, Atopic; Female; Healt

2007
Acetaminophen intake and risk of asthma, hay fever and eczema in early adolescence.
    Iranian journal of allergy, asthma, and immunology, 2007, Volume: 6, Issue:3

    Topics: Acetaminophen; Adolescent; Asthma; Eczema; Female; Humans; Male; Prevalence; Republic of North Maced

2007
Pre-natal exposure to paracetamol and risk of wheezing and asthma in children: a birth cohort study.
    International journal of epidemiology, 2008, Volume: 37, Issue:3

    Topics: Acetaminophen; Adult; Analgesics; Asthma; Bronchitis; Child; Denmark; Epidemiologic Methods; Female;

2008
Asthma associated with N-acetylcysteine infusion and paracetamol poisoning: report of two cases.
    British medical journal (Clinical research ed.), 1983, Sep-24, Volume: 287, Issue:6396

    Topics: Acetaminophen; Acetylcysteine; Adolescent; Asthma; Female; Humans

1983
Asthma associated with N-acetylcysteine infusion and paracetamol poisoning.
    British medical journal (Clinical research ed.), 1983, Oct-22, Volume: 287, Issue:6400

    Topics: Acetaminophen; Acetylcysteine; Asthma; Humans

1983
Asthma associated with N-acetylcysteine infusion and paracetamol poisoning.
    British medical journal (Clinical research ed.), 1984, Jan-14, Volume: 288, Issue:6411

    Topics: Acetaminophen; Acetylcysteine; Asthma; Humans

1984
Acetaminophen and aspirin challenges in subgroups of asthmatics.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 1983, Volume: 20 Suppl 1

    Topics: Acetaminophen; Adolescent; Adult; Aged; Anaphylaxis; Aspirin; Asthma; Bronchial Provocation Tests; D

1983
Acetaminophen, some other drugs, some diseases and the risk of transitional cell carcinoma. A population-based case-control study.
    Acta oncologica (Stockholm, Sweden), 1995, Volume: 34, Issue:6

    Topics: Acetaminophen; Age Factors; Analgesics; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Aspir

1995
Prevalence of cross-sensitivity with acetaminophen and other nonsteroidal antiinflammatory drugs in asthmatic patients.
    The Journal of allergy and clinical immunology, 1996, Volume: 98, Issue:3

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Cross Reactions; Female; Huma

1996
Long-term tolerability of nimesulide and acetaminophen in nonsteroidal antiinflammatory drug-intolerant patients.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1997, Volume: 79, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Angioedema; Ant

1997
Atopy and intolerance of antimicrobial drugs increase the risk of reactions to acetaminophen and nimesulide in patients allergic to nonsteroidal anti-inflammatory drugs.
    Allergy, 1998, Volume: 53, Issue:9

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Allergens; Anti-Inflammatory Agents, Non-

1998
Frequent paracetamol use and asthma in adults.
    Thorax, 2000, Volume: 55, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal;

2000
Frequent paracetamol use linked to asthma.
    Lancet (London, England), 2000, May-06, Volume: 355, Issue:9215

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Asthma; Humans; Oxidative Stress

2000
Drugs for pain.
    The Medical letter on drugs and therapeutics, 2000, Aug-21, Volume: 42, Issue:1085

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2000
Paracetamol sales and atopic disease in children and adults: an ecological analysis.
    The European respiratory journal, 2000, Volume: 16, Issue:5

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Asthma; Child; Drug Utilization; Epidemiologic

2000
Paracetamol and asthma.
    Thorax, 2000, Volume: 55, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Bronchial Hyperreactivity; Humans

2000
Paracetamol and asthma.
    Thorax, 2000, Volume: 55, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Humans; Selection Bias

2000
Paracetamol and asthma.
    Thorax, 2000, Volume: 55, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Bias; Confounding Factors, Epidemiologic; Humans

2000
Paracetamol and asthma.
    Thorax, 2000, Volume: 55, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Bias; Humans

2000
Paracetamol and asthma.
    Thorax, 2000, Volume: 55, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Bias; Glutathione; Humans; Practice Guidelines as T

2000
Paracetamol and asthma.
    Thorax, 2000, Volume: 55, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Glutathione; Humans; Viral Load

2000
Paracetamol and asthma.
    Thorax, 2000, Volume: 55, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; H

2000
Paracetamol and asthma.
    Thorax, 2001, Volume: 56, Issue:7

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asthma; Female; Humans; Male; Risk Factors; Statisti

2001
Clinical features and atopy profile in Turkish subjects with analgesic intolerance.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2002, Volume: 39, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Analgesics, Non-Narcotic; Anti-Bacterial Agents;

2002
Aspirin and concomitant idiosyncrasies in adult asthmatic patients.
    The Journal of allergy and clinical immunology, 1979, Volume: 64, Issue:6 Pt 1

    Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Aspirin; Asthma; Azo Compounds; Drug H

1979
Histamine and acetaminophen--a reader's "untoward" reaction.
    The Journal of the American Osteopathic Association, 1978, Volume: 78, Issue:3

    Topics: Acetaminophen; Aspirin; Asthma; Histamine; Humans

1978
Letter: Inhibition of prostaglandin biosynthesis by analgesics in relation to asthma.
    British medical journal, 1975, Mar-01, Volume: 1, Issue:5956

    Topics: Acetaminophen; Aspirin; Asthma; Depression, Chemical; Humans; Prostaglandins; Spirometry

1975
The diagnosis of aspirin idiosyncrasy by analgesic challenge.
    Clinical allergy, 1976, Volume: 6, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Airway Obstruction; Aspirin; Asthma; Drug Hypersensitivity;

1976
Aspirin-sensitive asthma: significance of the cyclooxygenase-inhibiting and protein-binding properties of analgesic drugs.
    International archives of allergy and applied immunology, 1991, Volume: 95, Issue:4

    Topics: Acetaminophen; Administration, Inhalation; Adult; Aged; Aspirin; Asthma; Dinoprost; Drug Tolerance;

1991
[Occurrence of drug reactions].
    Bollettino dell'Istituto sieroterapico milanese, 1986, Volume: 65, Issue:1

    Topics: Acetaminophen; Adult; Anaphylaxis; Angioedema; Aspirin; Asthma; Drug Hypersensitivity; Emergencies;

1986
Amplified bronchoconstrictive oscillations in experimental asthma.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 1985, Volume: 22, Issue:4

    Topics: Acetaminophen; Adult; Airway Resistance; Aspirin; Asthma; Bronchial Provocation Tests; Humans; Pleth

1985
Asthma caused by FD&C approved dyes.
    The Journal of allergy, 1967, Volume: 40, Issue:2

    Topics: Acetaminophen; Adult; Angioedema; Aspirin; Asthma; Benzoates; Coloring Agents; Cough; Diethylstilbes

1967
Response of aspirin-allergic patients to challenge by some analgesics in common use.
    British medical journal, 1971, May-29, Volume: 2, Issue:5760

    Topics: Acetaminophen; Adult; Analgesics; Aspirin; Asthma; Dextropropoxyphene; Drug Hypersensitivity; Female

1971