acetaminophen and Appendicitis studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Appendicitis: Acute inflammation of the APPENDIX. Acute appendicitis is classified as simple, gangrenous, or perforated.

Research Excerpts

Excerpt	Relevance	Reference
" With evidence suggesting that intravenous acetaminophen (IVA) can be an opioid sparing option, we conducted a prospective, randomized trial that evaluated the effect of IVA on the postoperative pain course of children with perforated appendicitis."	9.30	Does Intravenous Acetaminophen Improve Postoperative Pain Control after Laparoscopic Appendectomy for Perforated Appendicitis? A Prospective Randomized Trial. ( Desai, AA; Doyle, NM; Fraser, JD; Gonzalez, KW; Millspaugh, DL; Poola, AS; Sola, R; St Peter, SD; Weaver, KL, 2019)
" With evidence suggesting that intravenous acetaminophen (IVA) can be an opioid sparing option, we conducted a prospective, randomized trial that evaluated the effect of IVA on the postoperative pain course of children with perforated appendicitis."	5.30	Does Intravenous Acetaminophen Improve Postoperative Pain Control after Laparoscopic Appendectomy for Perforated Appendicitis? A Prospective Randomized Trial. ( Desai, AA; Doyle, NM; Fraser, JD; Gonzalez, KW; Millspaugh, DL; Poola, AS; Sola, R; St Peter, SD; Weaver, KL, 2019)
"There were no major intraoperative complications in either group."	2.67	Laparoscopic versus open appendicectomy: prospective randomised trial. ( Chung, SC; Dawson, JW; Lau, WY; Li, AK; Tate, JJ, 1993)
"Morphine requirements were markedly less for CLAWI."	1.42	Local anesthetic wound infusion versus standard analgesia in paediatric post-operative pain control. ( Albetyn, H; Cox, SG; Machoki, MS; Millar, AJ; Numanoglu, A; Thomas, J, 2015)

Research

Studies (11)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Average Pain Severity at the Umbilicus Laparoscopic Site

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (9.09)	18.2507
2000's	0 (0.00)	29.6817
2010's	6 (54.55)	24.3611
2020's	4 (36.36)	2.80

Authors	Studies
DeVitis, J	1
Flom, E	1
Cooper-Roth, T	1
Davis, A	1
Krech, L	1
Fisk, C	1
Pounders, S	1
Kwazneski, D	1
Chapman, A	1
Valdez, C	1
Yano, K	1
Muto, M	1
Nagai, T	1
Harumatsu, T	1
Kedoin, C	1
Nagano, A	1
Matsui, M	1
Murakami, M	1
Sugita, K	1
Onishi, S	1
Yamada, K	1
Yamada, W	1
Matsukubo, M	1
Kaji, T	1
Ieiri, S	1
Gee, KM	1
Jones, RE	1
Nevarez, N	1
McClain, LE	1
Wools, G	1
Beres, AL	1
Mahdi, EM	1
Ourshalimian, S	1
Darcy, D	1
Russell, CJ	1
Kelley-Quon, LI	1
Sola, R	1
Desai, AA	1
Gonzalez, KW	1
Doyle, NM	1
Weaver, KL	1
Poola, AS	1
Fraser, JD	1
St Peter, SD	1
Millspaugh, DL	1
Liu, Y	1
Seipel, C	1
Lopez, ME	1
Nuchtern, JG	1
Brandt, ML	1
Fallon, SC	1
Manyang, PA	1
Tjia, IM	1
Baijal, RG	1
Watcha, MF	1
Joshi, DS	1
Fleming, AE	1
Spottswood, SE	1
Machoki, MS	1
Millar, AJ	1
Albetyn, H	1
Cox, SG	1
Thomas, J	1
Numanoglu, A	1
Helbling, R	1
Conficconi, E	1
Wyttenbach, M	1
Benetti, C	1
Simonetti, GD	1
Bianchetti, MG	1
Hamitaga, F	1
Lava, SA	1
Fossali, EF	1
Milani, GP	1
Selbst, SM	1
Osterhoudt, K	1
Tate, JJ	1
Dawson, JW	1
Chung, SC	1
Lau, WY	1
Li, AK	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Comparing Narcotic vs. Non-narcotic Pain Regimens After Pediatric Appendectomy: A Randomized Controlled Trial[NCT03528343]	Phase 1/Phase 2	0 participants (Actual)	Interventional	2017-09-05	Withdrawn (stopped due to Lost research support for enrolling patients)
ROPIVACAINE WITH CLONIDINE FOR PEDIATRIC RECTUS SHEATH BLOCKS- THE MAGIC COMBINATION? - A Double Blinded Prospective Study[NCT02439281]		50 participants (Actual)	Interventional	2015-05-31	Terminated (stopped due to The patients were discharged on the day of the surgery.)
A Randomized, Double-blinded, Placebo-controlled Study of Ketorolac Use in Pediatric Patients Undergoing Tonsillectomy[NCT03453541]	Phase 4	600 participants (Anticipated)	Interventional	2017-11-21	Recruiting
The Evaluation of Pre-incisional and Post-closure Local Anesthetic vs. Normal Saline on Postoperative Pain in Pediatric Appendectomies[NCT02483689]		100 participants (Anticipated)	Interventional	2015-08-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Numeric Rating Pain Scores ( 0-10), will be obtained every 2 hours after PACU discharge up to 18 hours or until hospital discharge, whichever occurs first. The pain score of 0, means no pain, is a good outcome , and a pain score of 10 is excruciating pain, a very bad outcome. The average of these scores will be evaluated.The pain scores will not longer be documented after the numbness went away. (NCT02439281)
Timeframe: Logistic regression of the 4 th pain score assessment

Change in Anxiety Scores

Intervention	units on a scale (Median)
Ropivacaine Group	2
Ropivacaine/ Clonidine Group	1.5

The investigators hypothesize that patient postoperative anxiety scores are lower in the Ropivacaine/Clonidine group and postoperative anxiety scores decrease more in Ropivacaine /Clonidine Group, than in Ropivacaine Group. (NCT02439281)
Timeframe: 6 hours after block placement

Complications Rate

Intervention	units on a scale (Median)
Ropivacaine Group	30
Ropivacaine/ Clonidine Group	29

The investigators expect no difference in incidence of complications (e.g. oversedation, hypotension, bradycardia episodes, etc.). (NCT02439281)
Timeframe: until study completion

Duration of Analgesia at Umbilicus Instrument Site-How Many Minutes Passed From the Time When the Blocks Where Performed Until Patient Reported Pain at Umbilicus

Intervention	Participants (Count of Participants)
Ropivacaine/ Clonidine Group	1
Ropivacaine Group	1

The investigators hypothesize that rectus sheath injections with ropivacaine/ clonidine would result in longer duration of analgesia and decreased pain scores compared to ropivacaine alone. (NCT02439281)
Timeframe: indicated by the first request for pain medication at umbilicus site

Duration of Sensory Block (Paresthesia)

Intervention	minutes (Median)
Ropivacaine/ Clonidine Group	230
Ropivacaine Group	240

The investigators hypothesize that rectus sheath injections with ropivacaine and clonidine result in longer duration of sensory block (paresthesia) compared to ropivacaine alone. (NCT02439281)
Timeframe: Indicated by return of normal sensation (expected average of 12 hours after block placement).

Medication Consumption

Intervention	minutes (Median)
Ropivacaine/ Clonidine Group	823.5
Ropivacaine Group	540

Total intravenous morphine equivalents mg/kg (NCT02439281)
Timeframe: 18 hours after surgery

Satisfaction With Pain Control From Patient

Intervention	mg/kg (Median)
Ropivacaine/ Clonidine Group	0.20
Ropivacaine Group	0.22

The investigators hypothesize that rectus sheath injections with ropivacaine/ clonidine would result in better satisfaction with pain control. (NCT02439281)
Timeframe: Prior to hospital discharge (up to 24 hours after surgery)

Article	Year
The NOpioid Project: a prospective observational feasibility study examining the implementation of a non-narcotic post-operative pain control regimen. Surgical endoscopy, 2022, Volume: 36, Issue:11 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Appendectomy; Appendicitis; Feas	2022
The analgesic effect of the intravenous administration of acetaminophen for pediatric laparoscopic appendectomy: A comparison of scheduled and on-demand procedures. Asian journal of endoscopic surgery, 2022, Volume: 15, Issue:4 Topics: Acetaminophen; Acute Disease; Administration, Intravenous; Appendectomy; Appendicitis; Child; Humans	2022
No pain is gain: A prospective evaluation of strict non-opioid pain control after pediatric appendectomy. Journal of pediatric surgery, 2020, Volume: 55, Issue:6 Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Appendectomy; Appendicitis;	2020
The impact of intravenous acetaminophen pricing on opioid utilization and outcomes for children with appendicitis. Surgery, 2021, Volume: 170, Issue:3 Topics: Acetaminophen; Administration, Intravenous; Adolescent; Analgesics, Opioid; Appendectomy; Appendicit	2021
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children. Paediatric anaesthesia, 2013, Volume: 23, Issue:12 Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio	2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children. Paediatric anaesthesia, 2013, Volume: 23, Issue:12 Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio	2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children. Paediatric anaesthesia, 2013, Volume: 23, Issue:12 Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio	2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children. Paediatric anaesthesia, 2013, Volume: 23, Issue:12 Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio	2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children. Paediatric anaesthesia, 2013, Volume: 23, Issue:12 Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio	2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children. Paediatric anaesthesia, 2013, Volume: 23, Issue:12 Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio	2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children. Paediatric anaesthesia, 2013, Volume: 23, Issue:12 Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio	2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children. Paediatric anaesthesia, 2013, Volume: 23, Issue:12 Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio	2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children. Paediatric anaesthesia, 2013, Volume: 23, Issue:12 Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio	2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children. Paediatric anaesthesia, 2013, Volume: 23, Issue:12 Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio	2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children. Paediatric anaesthesia, 2013, Volume: 23, Issue:12 Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio	2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children. Paediatric anaesthesia, 2013, Volume: 23, Issue:12 Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio	2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children. Paediatric anaesthesia, 2013, Volume: 23, Issue:12 Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio	2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children. Paediatric anaesthesia, 2013, Volume: 23, Issue:12 Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio	2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children. Paediatric anaesthesia, 2013, Volume: 23, Issue:12 Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio	2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children. Paediatric anaesthesia, 2013, Volume: 23, Issue:12 Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio	2013
It's Not Appendicitis...? Consideration of a Benign Mimicker. Hospital pediatrics, 2015, Volume: 5, Issue:2 Topics: Abdomen, Acute; Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-S	2015
Local anesthetic wound infusion versus standard analgesia in paediatric post-operative pain control. Pediatric surgery international, 2015, Volume: 31, Issue:11 Topics: Acetaminophen; Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local	2015
Pediatric emergency medicine: legal briefs. Pediatric emergency care, 2012, Volume: 28, Issue:12 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aortic Aneurysm; Aortic Dissection; Appendicitis;	2012

acetaminophen and Appendicitis