acetaminophen and Apoplexy studies

acetaminophen and Apoplexy

acetaminophen has been researched along with Apoplexy in 56 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

Excerpt	Relevance	Reference
"PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2) was a multicenter, randomized, double-blind, placebo-controlled clinical trial."	9.24	PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial. ( Algra, A; de Ridder, IR; den Hertog, HM; Dippel, DW; Jansen, BP; Kappelle, LJ; Koudstaal, PJ; Maasland, EL; Ruitenberg, A; Saxena, R; Schreuder, AH; Van den Berg-Vos, RM; van der Worp, HB; van Gemert, HM; van Tuijl, JH; Vermeij, F, 2017)
"The Paracetamol (Acetaminophen) In Stroke 2 trial is a multicenter, randomized, double-blind, placebo-controlled clinical trial."	9.20	Paracetamol (Acetaminophen) in stroke 2 (PAIS 2): protocol for a randomized, placebo-controlled, double-blind clinical trial to assess the effect of high-dose paracetamol on functional outcome in patients with acute stroke and a body temperature of 36.5 ° ( Algra, A; de Jong, FJ; de Ridder, IR; den Hertog, HM; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Lingsma, HF; Maasland, EL; Oomes, P; Ruitenberg, A; Saxena, R; Schreuder, AH; van der Worp, HB; van Gemert, HM; van Tuijl, J, 2015)
"The Paracetamol (Acetaminophen) In Stroke (PAIS) study is a phase III multicenter, double blind, randomized, placebo-controlled clinical trial of high-dose acetaminophen in patients with acute stroke."	9.13	Correction: PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial. [ISCRTN74418480]. ( Algra, A; den Hertog, HM; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; van der Worp, HB; van Gemert, HM; van Gijn, J, 2008)
"In the majority of patients with acute ischemic stroke, ASA and acetaminophen are insufficient for reducing an elevated BT to a state of normothermia."	9.11	Acetylsalicylic acid and acetaminophen to combat elevated body temperature in acute ischemic stroke. ( De Keyser, J; Elting, JW; Luijckx, GJ; Luyckx, GJ; Maurits, N; Sulter, G, 2004)
"The authors assessed the time of onset of the hypothermic effect of acetaminophen in 102 patients with acute ischemic stroke."	9.10	Timing of the effect of acetaminophen on body temperature in patients with acute ischemic stroke. ( Algra, A; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2003)
"Treatment with a daily dose of 6000 mg acetaminophen results in a small, but potentially worthwhile decrease in body temperature after acute ischemic stroke, even in normothermic and subfebrile patients."	9.10	Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690]. ( Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Meijer, RJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2003)
"Early administration of acetaminophen (3900 mg/d) to afebrile patients with acute stroke may result in a small reduction in CBT."	9.10	Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial. ( Chalela, JA; Grotta, JC; Kasner, SE; Kimmel, SE; Krieger, DW; Morgenstern, LB; Piriyawat, P; Villar-Cordova, CE; Wein, T, 2002)
"Treatment with a daily dose of 6000 mg acetaminophen may result in a small, but potentially beneficial, decrease in body temperature shortly after ischemic stroke, even in normothermic and subfebrile patients."	9.09	Effect of paracetamol (acetaminophen) on body temperature in acute ischemic stroke: a double-blind, randomized phase II clinical trial. ( Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Meijer, RJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2001)
"Acetaminophen showed some capability to decrease body temperature for acute stroke."	8.95	Effect of paracetamol (acetaminophen) on body temperature in acute stroke: A meta-analysis. ( Chen, C; Cheng, H; Fang, J; Ma, L; Wang, R, 2017)
"The aim was to assess whether using LSPS matching would enable the evaluation of paracetamol, compared to ibuprofen, and increased risk of myocardial infarction, stroke, gastrointestinal (GI) bleeding, or acute renal failure."	7.96	Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen. ( Berlin, JA; Fife, D; Ryan, PB; Schuemie, MJ; Swerdel, J; Weinstein, RB, 2020)
" We determined whether paracetamol or ibuprofen use is associated with major cardiovascular events (MACE) or major bleeding in 19 120 patients with recent ischemic stroke or transient ischemic attack of mainly atherothrombotic origin included in the Prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) trial."	7.83	Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke. ( Amarenco, P; Bousser, MG; Chamorro, A; Fisher, M; Ford, I; Fox, KM; Gonzalez-Valcarcel, J; Hennerici, MG; Labreuche, J; Mattle, HP; Rothwell, PM; Sissani, L; Steg, PG; Vicaut, E, 2016)
"Oral tramadol/acetaminophen medication was effective at reducing pain levels in patients with CPSP, and is a medication option for the treatment of CPSP."	7.79	[Efficacy of tramadol/acetaminophen medication for central post-stroke pain]. ( Hirano, M; Kajita, Y; Nakahara, N; Noda, H; Takebayashi, S; Tanei, T; Wakabayashi, T, 2013)
" Acetaminophen has been tried in stroke patients to produce hypothermia so that injury following cerebral ischemia can be reduced."	7.76	Endothelin-A receptor antagonist BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral ischemia in rats. ( Briyal, S; Gulati, A, 2010)
"Paracetamol (Acetaminophen) In Stroke (PAIS) is a randomized, double-blind clinical trial, comparing high-dose acetaminophen with placebo in 2500 patients."	7.73	PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial [ISCRTN 74418480]. ( Algra, A; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; van Breda, EJ; van der Worp, HB; van Gemert, HM; van Gijn, J, 2005)
"Seventy-five (3 x 25) patients with acute ischaemic stroke confined to the anterior circulation will be randomised to treatment with either: 400 mg ibuprofen, 1000 mg acetaminophen, or with placebo 6 times daily during 5 days."	7.71	PISA. The effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute stroke: protocol for a phase II double-blind randomised placebo-controlled trial [ISRCTN98608690]. ( Dippel, DW; Kappelle, J; Koudstaal, PJ; Meijer, R; van Breda, EJ; van der Worp, B; van Gemert, M, 2002)
"Acetaminophen exposure was a time-dependent variable."	5.42	Acetaminophen use and risk of myocardial infarction and stroke in a hypertensive cohort. ( Dawson, J; Dominiczak, AF; Fulton, RL; McInnes, GT; Meredith, PA; Morrison, DS; Morton, R; Padmanabhan, S; Touyz, RM; Walters, MR, 2015)
"PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2) was a multicenter, randomized, double-blind, placebo-controlled clinical trial."	5.24	PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial. ( Algra, A; de Ridder, IR; den Hertog, HM; Dippel, DW; Jansen, BP; Kappelle, LJ; Koudstaal, PJ; Maasland, EL; Ruitenberg, A; Saxena, R; Schreuder, AH; Van den Berg-Vos, RM; van der Worp, HB; van Gemert, HM; van Tuijl, JH; Vermeij, F, 2017)
"The Paracetamol (Acetaminophen) In Stroke 2 trial is a multicenter, randomized, double-blind, placebo-controlled clinical trial."	5.20	Paracetamol (Acetaminophen) in stroke 2 (PAIS 2): protocol for a randomized, placebo-controlled, double-blind clinical trial to assess the effect of high-dose paracetamol on functional outcome in patients with acute stroke and a body temperature of 36.5 ° ( Algra, A; de Jong, FJ; de Ridder, IR; den Hertog, HM; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Lingsma, HF; Maasland, EL; Oomes, P; Ruitenberg, A; Saxena, R; Schreuder, AH; van der Worp, HB; van Gemert, HM; van Tuijl, J, 2015)
"The Paracetamol (Acetaminophen) In Stroke (PAIS) study is a phase III multicenter, double blind, randomized, placebo-controlled clinical trial of high-dose acetaminophen in patients with acute stroke."	5.13	Correction: PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial. [ISCRTN74418480]. ( Algra, A; den Hertog, HM; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; van der Worp, HB; van Gemert, HM; van Gijn, J, 2008)
"In the majority of patients with acute ischemic stroke, ASA and acetaminophen are insufficient for reducing an elevated BT to a state of normothermia."	5.11	Acetylsalicylic acid and acetaminophen to combat elevated body temperature in acute ischemic stroke. ( De Keyser, J; Elting, JW; Luijckx, GJ; Luyckx, GJ; Maurits, N; Sulter, G, 2004)
"The authors assessed the time of onset of the hypothermic effect of acetaminophen in 102 patients with acute ischemic stroke."	5.10	Timing of the effect of acetaminophen on body temperature in patients with acute ischemic stroke. ( Algra, A; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2003)
"Treatment with a daily dose of 6000 mg acetaminophen results in a small, but potentially worthwhile decrease in body temperature after acute ischemic stroke, even in normothermic and subfebrile patients."	5.10	Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690]. ( Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Meijer, RJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2003)
"Early administration of acetaminophen (3900 mg/d) to afebrile patients with acute stroke may result in a small reduction in CBT."	5.10	Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial. ( Chalela, JA; Grotta, JC; Kasner, SE; Kimmel, SE; Krieger, DW; Morgenstern, LB; Piriyawat, P; Villar-Cordova, CE; Wein, T, 2002)
"Treatment with a daily dose of 6000 mg acetaminophen may result in a small, but potentially beneficial, decrease in body temperature shortly after ischemic stroke, even in normothermic and subfebrile patients."	5.09	Effect of paracetamol (acetaminophen) on body temperature in acute ischemic stroke: a double-blind, randomized phase II clinical trial. ( Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Meijer, RJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2001)
"Acetaminophen showed some capability to decrease body temperature for acute stroke."	4.95	Effect of paracetamol (acetaminophen) on body temperature in acute stroke: A meta-analysis. ( Chen, C; Cheng, H; Fang, J; Ma, L; Wang, R, 2017)
"The aim was to assess whether using LSPS matching would enable the evaluation of paracetamol, compared to ibuprofen, and increased risk of myocardial infarction, stroke, gastrointestinal (GI) bleeding, or acute renal failure."	3.96	Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen. ( Berlin, JA; Fife, D; Ryan, PB; Schuemie, MJ; Swerdel, J; Weinstein, RB, 2020)
" We determined whether paracetamol or ibuprofen use is associated with major cardiovascular events (MACE) or major bleeding in 19 120 patients with recent ischemic stroke or transient ischemic attack of mainly atherothrombotic origin included in the Prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) trial."	3.83	Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke. ( Amarenco, P; Bousser, MG; Chamorro, A; Fisher, M; Ford, I; Fox, KM; Gonzalez-Valcarcel, J; Hennerici, MG; Labreuche, J; Mattle, HP; Rothwell, PM; Sissani, L; Steg, PG; Vicaut, E, 2016)
"Oral tramadol/acetaminophen medication was effective at reducing pain levels in patients with CPSP, and is a medication option for the treatment of CPSP."	3.79	[Efficacy of tramadol/acetaminophen medication for central post-stroke pain]. ( Hirano, M; Kajita, Y; Nakahara, N; Noda, H; Takebayashi, S; Tanei, T; Wakabayashi, T, 2013)
" Acetaminophen has been tried in stroke patients to produce hypothermia so that injury following cerebral ischemia can be reduced."	3.76	Endothelin-A receptor antagonist BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral ischemia in rats. ( Briyal, S; Gulati, A, 2010)
"Paracetamol (Acetaminophen) In Stroke (PAIS) is a randomized, double-blind clinical trial, comparing high-dose acetaminophen with placebo in 2500 patients."	3.73	PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial [ISCRTN 74418480]. ( Algra, A; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; van Breda, EJ; van der Worp, HB; van Gemert, HM; van Gijn, J, 2005)
"Seventy-five (3 x 25) patients with acute ischaemic stroke confined to the anterior circulation will be randomised to treatment with either: 400 mg ibuprofen, 1000 mg acetaminophen, or with placebo 6 times daily during 5 days."	3.71	PISA. The effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute stroke: protocol for a phase II double-blind randomised placebo-controlled trial [ISRCTN98608690]. ( Dippel, DW; Kappelle, J; Koudstaal, PJ; Meijer, R; van Breda, EJ; van der Worp, B; van Gemert, M, 2002)
"Severe infarcts and intracerebral hemorrhages caused temperature to rise, whereas initially increased temperature had no influence on stroke severity."	2.70	Stroke severity determines body temperature in acute stroke. ( Boysen, G; Christensen, H, 2001)
" A recent systematic review found increased adverse events and mortality at therapeutic dosage."	1.51	Acetaminophen Safety: Risk of Mortality and Cardiovascular Events in Nursing Home Residents, a Prospective Study. ( Cantet, C; de Souto Barreto, P; Girard, P; Rolland, Y; Sourdet, S, 2019)
"Migraine was present in 226 (75."	1.43	CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships. ( Markus, HS; Tan, RY, 2016)
"Acetaminophen exposure was a time-dependent variable."	1.42	Acetaminophen use and risk of myocardial infarction and stroke in a hypertensive cohort. ( Dawson, J; Dominiczak, AF; Fulton, RL; McInnes, GT; Meredith, PA; Morrison, DS; Morton, R; Padmanabhan, S; Touyz, RM; Walters, MR, 2015)
"Compared to conventional treatment, fever burden was significantly lower within the first 4 days after admission (p < 0."	1.37	Standardized antipyretic treatment in stroke: a pilot study. ( Beck, A; Breuer, L; Kallmünzer, B; Köhrmann, M; Kollmar, R; Krause, C; Pauli, E, 2011)
"Fever in acute stroke is associated with poor prognosis, but evidence-based recommendations on antipyretic therapy are lacking."	1.36	[Antipyretic strategies for acute stroke: a nationwide survey among German stroke units]. ( Beck, A; Kallmünzer, B; Kollmar, R; Schwab, S, 2010)
" The drug's effect as well as adverse effects should be actively sought, and dosage alterations made in order to enhance the drug's effect."	1.32	Introduction to monitoring. What is what you prescribed actually doing? ( George, A; Shakib, S, 2003)

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	25 (44.64)	29.6817
2010's	30 (53.57)	24.3611
2020's	1 (1.79)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

25 (44.64)

29.6817

2010's

30 (53.57)

24.3611

2020's

1 (1.79)

2.80

Authors

Authors	Studies
Friesen, RW	1
Mancini, JA	1
Lai, SW	1
Lin, CL	1
Girard, P	2
Cantet, C	2
Rolland, Y	2
Weinstein, RB	1
Ryan, PB	1
Berlin, JA	1
Schuemie, MJ	1
Swerdel, J	1
Fife, D	1
Fang, J	1
Chen, C	1
Cheng, H	1
Wang, R	1
Ma, L	1
de Ridder, IR	4
Dippel, DWJ	1
van der Worp, HB	17
Noubiap, JJ	1
Kamtchum-Tatuene, J	1
Raza, SA	1
Durm, LB	1
Mahmoud, GA	1
Rahman, H	1
Henriquez, L	1
Davis, B	1
Nahab, F	1
Sourdet, S	1
de Souto Barreto, P	1
Frank, B	1
Fulton, RL	2
Weimar, C	1
Lees, KR	1
Sanders, RD	1
de Ridder, I	1
den Hertog, H	1
van Gemert, M	2
Dippel, D	1
van der Worp, B	2
de Jong, FJ	1
den Hertog, HM	9
Lingsma, HF	1
van Gemert, HM	15
Schreuder, AH	3
Ruitenberg, A	3
Maasland, EL	3
Saxena, R	3
Oomes, P	1
van Tuijl, J	1
Koudstaal, PJ	13
Kappelle, LJ	11
Algra, A	9
Dippel, DW	17
Tanei, T	1
Kajita, Y	1
Noda, H	1
Takebayashi, S	1
Hirano, M	1
Nakahara, N	1
Wakabayashi, T	1
Saxena, MK	1
Taylor, CB	1
Hammond, NE	1
Young, PJ	1
Seppelt, IM	1
Glass, P	1
Myburgh, JA	1
Dumont, Z	1
Mordasiewicz, M	1
Kosar, L	1
Schuster, B	1
Drury, P	1
Levi, C	1
McInnes, E	2
Hardy, J	1
Ward, J	1
Grimshaw, JM	2
D' Este, C	1
Dale, S	2
McElduff, P	1
Cheung, NW	1
Quinn, C	1
Griffiths, R	1
Evans, M	1
Cadilhac, D	1
Middleton, S	2
García-Poza, P	1
de Abajo, FJ	1
Gil, MJ	1
Chacón, A	1
Bryant, V	1
García-Rodríguez, LA	1
Walters, MR	1
Morton, R	1
Touyz, RM	1
Dominiczak, AF	1
Morrison, DS	1
Padmanabhan, S	1
Meredith, PA	1
McInnes, GT	1
Dawson, J	1
Glasser, SP	1
Khodneva, Y	1
Gonzalez-Valcarcel, J	1
Sissani, L	1
Labreuche, J	1
Bousser, MG	1
Chamorro, A	1
Fisher, M	1
Ford, I	1
Fox, KM	1
Hennerici, MG	1
Mattle, HP	1
Rothwell, PM	1
Steg, PG	1
Vicaut, E	1
Amarenco, P	1
Tan, RY	1
Markus, HS	1
Iannuccelli, C	1
Di Franco, M	1
Pulcinelli, FM	1
Craig, LE	1
Churilov, L	1
Olenko, L	1
Cadilhac, DA	1
Grimley, R	1
Martinez-Garduno, C	1
Considine, J	1
van Tuijl, JH	1
Jansen, BP	1
Van den Berg-Vos, RM	1
Vermeij, F	1
van Gijn, J	7
Tseng, MC	1
Kasner, SE	2
Kallmünzer, B	2
Beck, A	2
Schwab, S	1
Kollmar, R	2
Briyal, S	1
Gulati, A	1
Krause, C	1
Pauli, E	1
Breuer, L	1
Köhrmann, M	1
Meisel, A	1
Wrotek, SE	1
Kozak, WE	1
Hess, DC	1
Fagan, SC	1
Takagi, K	1
van Breda, EJ	7
Meijer, RJ	2
Shakib, S	1
George, A	1
Sulter, G	1
Elting, JW	1
Maurits, N	1
Luijckx, GJ	1
Luyckx, GJ	1
De Keyser, J	1
Wong, AA	1
Davis, JP	1
Schluter, PJ	1
Henderson, RD	1
O'Sullivan, JD	1
Read, SJ	1
Boysen, G	1
Christensen, H	1
Crome, P	1
Rizeq, M	1
George, S	1
Braithwaite, RA	1
Jones, PW	1
Koennecke, HC	2
Leistner, S	1
Wein, T	1
Piriyawat, P	1
Villar-Cordova, CE	1
Chalela, JA	1
Krieger, DW	1
Morgenstern, LB	1
Kimmel, SE	1
Grotta, JC	1
Meijer, R	1
Kappelle, J	1
Ellrodt, A	1

Studies

Friesen, RW

Mancini, JA

Lai, SW

Lin, CL

Girard, P

Cantet, C

Rolland, Y

Weinstein, RB

Ryan, PB

Berlin, JA

Schuemie, MJ

Swerdel, J

Fife, D

Fang, J

Chen, C

Cheng, H

Wang, R

Ma, L

de Ridder, IR

Dippel, DWJ

van der Worp, HB

Noubiap, JJ

Kamtchum-Tatuene, J

Raza, SA

Durm, LB

Mahmoud, GA

Rahman, H

Henriquez, L

Davis, B

Nahab, F

Sourdet, S

de Souto Barreto, P

Frank, B

Fulton, RL

Weimar, C

Lees, KR

Sanders, RD

de Ridder, I

den Hertog, H

van Gemert, M

Dippel, D

van der Worp, B

de Jong, FJ

den Hertog, HM

Lingsma, HF

van Gemert, HM

Schreuder, AH

Ruitenberg, A

Maasland, EL

Saxena, R

Oomes, P

van Tuijl, J

Koudstaal, PJ

Kappelle, LJ

Algra, A

Dippel, DW

Tanei, T

Kajita, Y

Noda, H

Takebayashi, S

Hirano, M

Nakahara, N

Wakabayashi, T

Saxena, MK

Taylor, CB

Hammond, NE

Young, PJ

Seppelt, IM

Glass, P

Myburgh, JA

Dumont, Z

Mordasiewicz, M

Kosar, L

Schuster, B

Drury, P

Levi, C

McInnes, E

Hardy, J

Ward, J

Grimshaw, JM

D' Este, C

Dale, S

McElduff, P

Cheung, NW

Quinn, C

Griffiths, R

Evans, M

Cadilhac, D

Middleton, S

García-Poza, P

de Abajo, FJ

Gil, MJ

Chacón, A

Bryant, V

García-Rodríguez, LA

Walters, MR

Morton, R

Touyz, RM

Dominiczak, AF

Morrison, DS

Padmanabhan, S

Meredith, PA

McInnes, GT

Dawson, J

Glasser, SP

Khodneva, Y

Gonzalez-Valcarcel, J

Sissani, L

Labreuche, J

Bousser, MG

Chamorro, A

Fisher, M

Ford, I

Fox, KM

Hennerici, MG

Mattle, HP

Rothwell, PM

Steg, PG

Vicaut, E

Amarenco, P

Tan, RY

Markus, HS

Iannuccelli, C

Di Franco, M

Pulcinelli, FM

Craig, LE

Churilov, L

Olenko, L

Cadilhac, DA

Grimley, R

Martinez-Garduno, C

Considine, J

van Tuijl, JH

Jansen, BP

Van den Berg-Vos, RM

Vermeij, F

van Gijn, J

Tseng, MC

Kasner, SE

Kallmünzer, B

Beck, A

Schwab, S

Kollmar, R

Briyal, S

Gulati, A

Krause, C

Pauli, E

Breuer, L

Köhrmann, M

Meisel, A

Wrotek, SE

Kozak, WE

Hess, DC

Fagan, SC

Takagi, K

van Breda, EJ

Meijer, RJ

Shakib, S

George, A

Sulter, G

Elting, JW

Maurits, N

Luijckx, GJ

Luyckx, GJ

De Keyser, J

Wong, AA

Davis, JP

Schluter, PJ

Henderson, RD

O'Sullivan, JD

Read, SJ

Boysen, G

Christensen, H

Crome, P

Rizeq, M

George, S

Braithwaite, RA

Jones, PW

Koennecke, HC

Leistner, S

Wein, T

Piriyawat, P

Villar-Cordova, CE

Chalela, JA

Krieger, DW

Morgenstern, LB

Kimmel, SE

Grotta, JC

Meijer, R

Kappelle, J

Ellrodt, A

Reviews

3 reviews available for acetaminophen and Apoplexy

Article	Year
Effect of paracetamol (acetaminophen) on body temperature in acute stroke: A meta-analysis. The American journal of emergency medicine, 2017, Volume: 35, Issue:10 Topics: Acetaminophen; Antipyretics; Body Temperature; Humans; Stroke	2017
Cooling therapy for acute stroke. The Cochrane database of systematic reviews, 2009, Jan-21, Issue:1 Topics: Acetaminophen; Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Humans; Hypothermia	2009
Treatment of fever after stroke: conflicting evidence. Pharmacotherapy, 2011, Volume: 31, Issue:11 Topics: Acetaminophen; Animals; Antipyretics; Body Temperature; Fever; Humans; Severity of Illness Index; St	2011

Article

Year

Effect of paracetamol (acetaminophen) on body temperature in acute stroke: A meta-analysis.

The American journal of emergency medicine, 2017, Volume: 35, Issue:10

Topics: Acetaminophen; Antipyretics; Body Temperature; Humans; Stroke

2017

Cooling therapy for acute stroke.

The Cochrane database of systematic reviews, 2009, Jan-21, Issue:1

Topics: Acetaminophen; Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Humans; Hypothermia

2009

Treatment of fever after stroke: conflicting evidence.

Pharmacotherapy, 2011, Volume: 31, Issue:11

Topics: Acetaminophen; Animals; Antipyretics; Body Temperature; Fever; Humans; Severity of Illness Index; St

2011

Trials

14 trials available for acetaminophen and Apoplexy

Article	Year
Increased benefit of alteplase in patients with ischemic stroke and a high body temperature. Cerebrovascular diseases (Basel, Switzerland), 2013, Volume: 35, Issue:1 Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Body Temperature; Brain Ischemia; Double-Blind	2013
Paracetamol (Acetaminophen) in stroke 2 (PAIS 2): protocol for a randomized, placebo-controlled, double-blind clinical trial to assess the effect of high-dose paracetamol on functional outcome in patients with acute stroke and a body temperature of 36.5 ° International journal of stroke : official journal of the International Stroke Society, 2015, Volume: 10, Issue:3 Topics: Acetaminophen; Antipyretics; Body Temperature; Clinical Protocols; Dose-Response Relationship, Drug;	2015
Temperature management in patients with acute neurological lesions: an Australian and New Zealand point prevalence study. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2013, Volume: 15, Issue:2 Topics: Acetaminophen; Antipyretics; Australia; Body Temperature; Brain Injuries; Dose-Response Relationship	2013
PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial. Stroke, 2017, Volume: 48, Issue:4 Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Brain Ischemia; Cerebral Hemorrhage; Double-Bl	2017
Correction: PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial. [ISCRTN74418480]. BMC cardiovascular disorders, 2008, Nov-04, Volume: 8 Topics: Acetaminophen; Analgesics, Non-Narcotic; Clinical Protocols; Double-Blind Method; Fever; Humans; Log	2008
The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial. The Lancet. Neurology, 2009, Volume: 8, Issue:5 Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Brain Ischemia; Fema	2009
Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690]. BMC cardiovascular disorders, 2003, Feb-06, Volume: 3 Topics: Acetaminophen; Acute Disease; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroida	2003
Timing of the effect of acetaminophen on body temperature in patients with acute ischemic stroke. Neurology, 2003, Sep-09, Volume: 61, Issue:5 Topics: Acetaminophen; Acute Disease; Aged; Body Temperature; Brain Ischemia; Double-Blind Method; Female; H	2003
[Treatment of stroke by reducing the body temperature; 'Paracetamol (acetaminophen) in stroke' (PAIS): start of a clinical trial]. Nederlands tijdschrift voor geneeskunde, 2003, Oct-04, Volume: 147, Issue:40 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Body Temperature; Double-Blind Method; Fever	2003
Acetylsalicylic acid and acetaminophen to combat elevated body temperature in acute ischemic stroke. Cerebrovascular diseases (Basel, Switzerland), 2004, Volume: 17, Issue:2-3 Topics: Acetaminophen; Acute Disease; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroida	2004
Stroke severity determines body temperature in acute stroke. Stroke, 2001, Volume: 32, Issue:2 Topics: Acetaminophen; Acute Disease; Aged; Aged, 80 and over; Anticoagulants; Body Temperature; Cerebral He	2001
Effect of paracetamol (acetaminophen) on body temperature in acute ischemic stroke: a double-blind, randomized phase II clinical trial. Stroke, 2001, Volume: 32, Issue:7 Topics: Acetaminophen; Acute Disease; Aged; Body Temperature; Brain Ischemia; Double-Blind Method; Female; F	2001
Prophylactic antipyretic treatment with acetaminophen in acute ischemic stroke: a pilot study. Neurology, 2001, Dec-26, Volume: 57, Issue:12 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Ischemia; Double-Blind Method; Female; Humans;	2001
Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial. Stroke, 2002, Volume: 33, Issue:1 Topics: Acetaminophen; Acute Disease; Aged; Body Temperature; Double-Blind Method; Female; Fever; Humans; Hy	2002

Article

Year

Increased benefit of alteplase in patients with ischemic stroke and a high body temperature.

Cerebrovascular diseases (Basel, Switzerland), 2013, Volume: 35, Issue:1

Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Body Temperature; Brain Ischemia; Double-Blind

2013

Paracetamol (Acetaminophen) in stroke 2 (PAIS 2): protocol for a randomized, placebo-controlled, double-blind clinical trial to assess the effect of high-dose paracetamol on functional outcome in patients with acute stroke and a body temperature of 36.5 °

International journal of stroke : official journal of the International Stroke Society, 2015, Volume: 10, Issue:3

Topics: Acetaminophen; Antipyretics; Body Temperature; Clinical Protocols; Dose-Response Relationship, Drug;

2015

Temperature management in patients with acute neurological lesions: an Australian and New Zealand point prevalence study.

Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2013, Volume: 15, Issue:2

Topics: Acetaminophen; Antipyretics; Australia; Body Temperature; Brain Injuries; Dose-Response Relationship

2013

PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial.

Stroke, 2017, Volume: 48, Issue:4

Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Brain Ischemia; Cerebral Hemorrhage; Double-Bl

2017

Correction: PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial. [ISCRTN74418480].

BMC cardiovascular disorders, 2008, Nov-04, Volume: 8

Topics: Acetaminophen; Analgesics, Non-Narcotic; Clinical Protocols; Double-Blind Method; Fever; Humans; Log

2008

The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial.

The Lancet. Neurology, 2009, Volume: 8, Issue:5

Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Brain Ischemia; Fema

2009

Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690].

BMC cardiovascular disorders, 2003, Feb-06, Volume: 3

Topics: Acetaminophen; Acute Disease; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroida

2003

Timing of the effect of acetaminophen on body temperature in patients with acute ischemic stroke.

Neurology, 2003, Sep-09, Volume: 61, Issue:5

Topics: Acetaminophen; Acute Disease; Aged; Body Temperature; Brain Ischemia; Double-Blind Method; Female; H

2003

[Treatment of stroke by reducing the body temperature; 'Paracetamol (acetaminophen) in stroke' (PAIS): start of a clinical trial].

Nederlands tijdschrift voor geneeskunde, 2003, Oct-04, Volume: 147, Issue:40

Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Body Temperature; Double-Blind Method; Fever

2003

Acetylsalicylic acid and acetaminophen to combat elevated body temperature in acute ischemic stroke.

Cerebrovascular diseases (Basel, Switzerland), 2004, Volume: 17, Issue:2-3

Topics: Acetaminophen; Acute Disease; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroida

2004

Stroke severity determines body temperature in acute stroke.

Stroke, 2001, Volume: 32, Issue:2

Topics: Acetaminophen; Acute Disease; Aged; Aged, 80 and over; Anticoagulants; Body Temperature; Cerebral He

2001

Effect of paracetamol (acetaminophen) on body temperature in acute ischemic stroke: a double-blind, randomized phase II clinical trial.

Stroke, 2001, Volume: 32, Issue:7

Topics: Acetaminophen; Acute Disease; Aged; Body Temperature; Brain Ischemia; Double-Blind Method; Female; F

2001

Prophylactic antipyretic treatment with acetaminophen in acute ischemic stroke: a pilot study.

Neurology, 2001, Dec-26, Volume: 57, Issue:12

Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Ischemia; Double-Blind Method; Female; Humans;

2001

Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial.

Stroke, 2002, Volume: 33, Issue:1

Topics: Acetaminophen; Acute Disease; Aged; Body Temperature; Double-Blind Method; Female; Fever; Humans; Hy

2002

Other Studies

39 other studies available for acetaminophen and Apoplexy

Article	Year
Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target. Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atherosclerosis; Fever; Humans; Intramolecular Oxi	2008
Acetaminophen Use and Stroke Risk. Journal of the American Geriatrics Society, 2019, Volume: 67, Issue:11 Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Humans; Incidence; Risk Assessment; Stroke; Taiwan	2019
Reply to Acetaminophen Use and Stroke Risk. Journal of the American Geriatrics Society, 2019, Volume: 67, Issue:11 Topics: Acetaminophen; Analgesics, Non-Narcotic; Fever; Humans; Stroke	2019
Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen. Drug safety, 2020, Volume: 43, Issue:9 Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Ag	2020
Response by de Ridder et al to Letter Regarding Article, "PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2) Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial". Stroke, 2017, Volume: 48, Issue:7 Topics: Acetaminophen; Analgesics, Non-Narcotic; Double-Blind Method; Humans; Plasminogen Activator Inhibito	2017
Letter by Noubiap and Kamtchum-Tatuene Regarding Article, "PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial". Stroke, 2017, Volume: 48, Issue:7 Topics: Acetaminophen; Analgesics, Non-Narcotic; Double-Blind Method; Humans; Plasminogen Activator Inhibito	2017
Over-the-counter analgesic powder use in patients presenting with intracerebral hemorrhage: A case series. Medicine, 2018, Volume: 97, Issue:15 Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Black or African American; Cerebral Hemorrhage; Dos	2018
Acetaminophen Safety: Risk of Mortality and Cardiovascular Events in Nursing Home Residents, a Prospective Study. Journal of the American Geriatrics Society, 2019, Volume: 67, Issue:6 Topics: Acetaminophen; Aged, 80 and over; Analgesics, Non-Narcotic; Female; France; Humans; Male; Mortality;	2019
Use of paracetamol in ischaemic stroke patients: evidence from VISTA. Acta neurologica Scandinavica, 2013, Volume: 128, Issue:3 Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Brain Ischemia; Female; Fever; Hum	2013
[Efficacy of tramadol/acetaminophen medication for central post-stroke pain]. No shinkei geka. Neurological surgery, 2013, Volume: 41, Issue:8 Topics: Acetaminophen; Aged; Female; Humans; Japan; Male; Middle Aged; Pain; Pain Measurement; Stroke; Trama	2013
Warfarin: its highs and lows. Canadian family physician Medecin de famille canadien, 2013, Volume: 59, Issue:8 Topics: Acetaminophen; Aged, 80 and over; Analgesics, Non-Narcotic; Anticoagulants; Atrial Fibrillation; Cho	2013
Management of fever, hyperglycemia, and swallowing dysfunction following hospital admission for acute stroke in New South Wales, Australia. International journal of stroke : official journal of the International Stroke Society, 2014, Volume: 9, Issue:1 Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Cohort Studies; Deglutition Disorders; Female;	2014
Risk of ischemic stroke associated with non-steroidal anti-inflammatory drugs and paracetamol: a population-based case-control study. Journal of thrombosis and haemostasis : JTH, 2015, Volume: 13, Issue:5 Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischem	2015
Acetaminophen use and risk of myocardial infarction and stroke in a hypertensive cohort. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:5 Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Chronic Pain; Confounding Factors, Ep	2015
Should acetaminophen be added to the list of anti-inflammatory agents that are associated with cardiovascular events? Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:5 Topics: Acetaminophen; Blood Pressure; Chronic Pain; Female; Humans; Hypertension; Male; Myocardial Infarcti	2015
Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke. Stroke, 2016, Volume: 47, Issue:4 Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Brain Ischemia; Cardiovascular Diseases; Female; Hemo	2016
CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships. PloS one, 2016, Volume: 11, Issue:6 Topics: Acetaminophen; Adult; Age of Onset; Aged; Aged, 80 and over; Analgesics; CADASIL; Codeine; Cross-Sec	2016
Letter by Iannuccelli et al Regarding Article, "Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke". Stroke, 2016, Volume: 47, Issue:9 Topics: Acetaminophen; Brain Ischemia; Hemorrhage; Humans; Ibuprofen; Stroke	2016
Testing a systematic approach to identify and prioritise barriers to successful implementation of a complex healthcare intervention. BMC medical research methodology, 2017, 02-07, Volume: 17, Issue:1 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Australia; Emergency Medical Services; Emergency Ser	2017
Paracetamol for stroke: easy in practice, but not in trials. The Lancet. Neurology, 2009, Volume: 8, Issue:5 Topics: Acetaminophen; Anti-Inflammatory Agents; Clinical Trials as Topic; Humans; Hypothermia, Induced; Str	2009
Confusion and stroke due to an "umbrella brand" product. Prescrire international, 2008, Volume: 17, Issue:96 Topics: Acetaminophen; Canada; Diphenhydramine; Drug Combinations; Drug Labeling; France; Humans; Medication	2008
High-dose paracetamol in stroke: new trials are necessary and feasible. The Lancet. Neurology, 2009, Volume: 8, Issue:8 Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Clinical Trials as Topic; Humans; Stroke	2009
[Antipyretic strategies for acute stroke: a nationwide survey among German stroke units]. Der Nervenarzt, 2010, Volume: 81, Issue:6 Topics: Acetaminophen; Analgesics, Non-Narcotic; Cryotherapy; Data Collection; Dipyrone; Germany; Hospitals,	2010
Endothelin-A receptor antagonist BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral ischemia in rats. European journal of pharmacology, 2010, Oct-10, Volume: 644, Issue:1-3 Topics: Acetaminophen; Animals; Antipyretics; Brain Ischemia; Disease Models, Animal; Drug Synergism; Endoth	2010
An early rise in body temperature is related to unfavorable outcome after stroke: data from the PAIS study. Journal of neurology, 2011, Volume: 258, Issue:2 Topics: Acetaminophen; Aged; Antipyretics; Female; Fever; Humans; Male; Multicenter Studies as Topic; Random	2011
Standardized antipyretic treatment in stroke: a pilot study. Cerebrovascular diseases (Basel, Switzerland), 2011, Volume: 31, Issue:4 Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Body Temperature Regulation; Case-Control Stud	2011
Effective fever control in acute stroke: still wanted! Cerebrovascular diseases (Basel, Switzerland), 2011, Volume: 31, Issue:4 Topics: Acetaminophen; Antipyretics; Body Temperature Regulation; Combined Modality Therapy; Dipyrone; Fever	2011
Effects of high-dose paracetamol on blood pressure in acute stroke. Acta neurologica Scandinavica, 2012, Volume: 125, Issue:4 Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Blood Pressure; Blood Pressure Determination;	2012
[Does paracetamol improve recovery after stroke?]. Nederlands tijdschrift voor geneeskunde, 2011, Volume: 155, Issue:46 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Fever; Hum	2011
Body temperature in acute stroke. Stroke, 2002, Volume: 33, Issue:9 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Body Temperature; Disease Progression; Fever; Huma	2002
Introduction to monitoring. What is what you prescribed actually doing? Australian family physician, 2003, Volume: 32, Issue:10 Topics: Acetaminophen; Aged; Aspirin; Australia; Celecoxib; Drug Interactions; Drug Therapy, Combination; Fa	2003
Reduction of body temperature with paracetamol in patients with acute stroke: randomised clinical trials are needed. Cerebrovascular diseases (Basel, Switzerland), 2004, Volume: 18, Issue:4 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Fever; Hu	2004
PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial [ISCRTN 74418480]. BMC cardiovascular disorders, 2005, Aug-19, Volume: 5 Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Clinical Protocols; Double-Blind Method;	2005
The time course and determinants of temperature within the first 48 h after ischaemic stroke. Cerebrovascular diseases (Basel, Switzerland), 2007, Volume: 24, Issue:1 Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Bacterial Infec	2007
Acetaminophen for temperature reduction in acute stroke: potential but unproven benefits. Stroke, 2007, Volume: 38, Issue:11 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Body Temperature; Clinical Trials as Topic;	2007
Drug absorption may be delayed after stroke: results of the paracetamol absorption test. Age and ageing, 2001, Volume: 30, Issue:5 Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Gastric Emptying; Humans; Intestinal	2001
Modification of body temperature after acute stroke: a new concept needed? Stroke, 2002, Volume: 33, Issue:1 Topics: Acetaminophen; Acute Disease; Body Temperature; Double-Blind Method; Fever; Humans; Hypothermia; Str	2002
PISA. The effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute stroke: protocol for a phase II double-blind randomised placebo-controlled trial [ISRCTN98608690]. BMC cardiovascular disorders, 2002, Mar-27, Volume: 2 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Clinical Trials, Phase II	2002
Assessing the risks of cervical manipulation for neck pain. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2002, Apr-30, Volume: 166, Issue:9 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cervical Vertebrae; Evidence-Based Medicine;	2002

Article

Year

Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target.

Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atherosclerosis; Fever; Humans; Intramolecular Oxi

2008

Acetaminophen Use and Stroke Risk.

Journal of the American Geriatrics Society, 2019, Volume: 67, Issue:11

Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Humans; Incidence; Risk Assessment; Stroke; Taiwan

2019

Reply to Acetaminophen Use and Stroke Risk.

Journal of the American Geriatrics Society, 2019, Volume: 67, Issue:11

Topics: Acetaminophen; Analgesics, Non-Narcotic; Fever; Humans; Stroke

2019

Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen.

Drug safety, 2020, Volume: 43, Issue:9

Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Ag

2020

Response by de Ridder et al to Letter Regarding Article, "PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2) Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial".

Stroke, 2017, Volume: 48, Issue:7

Topics: Acetaminophen; Analgesics, Non-Narcotic; Double-Blind Method; Humans; Plasminogen Activator Inhibito

2017

Letter by Noubiap and Kamtchum-Tatuene Regarding Article, "PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial".

Stroke, 2017, Volume: 48, Issue:7

Topics: Acetaminophen; Analgesics, Non-Narcotic; Double-Blind Method; Humans; Plasminogen Activator Inhibito

2017

Over-the-counter analgesic powder use in patients presenting with intracerebral hemorrhage: A case series.

Medicine, 2018, Volume: 97, Issue:15

Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Black or African American; Cerebral Hemorrhage; Dos

2018

Acetaminophen Safety: Risk of Mortality and Cardiovascular Events in Nursing Home Residents, a Prospective Study.

Journal of the American Geriatrics Society, 2019, Volume: 67, Issue:6

Topics: Acetaminophen; Aged, 80 and over; Analgesics, Non-Narcotic; Female; France; Humans; Male; Mortality;

2019

Use of paracetamol in ischaemic stroke patients: evidence from VISTA.

Acta neurologica Scandinavica, 2013, Volume: 128, Issue:3

Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Brain Ischemia; Female; Fever; Hum

2013

[Efficacy of tramadol/acetaminophen medication for central post-stroke pain].

No shinkei geka. Neurological surgery, 2013, Volume: 41, Issue:8

Topics: Acetaminophen; Aged; Female; Humans; Japan; Male; Middle Aged; Pain; Pain Measurement; Stroke; Trama

2013

Warfarin: its highs and lows.

Canadian family physician Medecin de famille canadien, 2013, Volume: 59, Issue:8

Topics: Acetaminophen; Aged, 80 and over; Analgesics, Non-Narcotic; Anticoagulants; Atrial Fibrillation; Cho

2013

Management of fever, hyperglycemia, and swallowing dysfunction following hospital admission for acute stroke in New South Wales, Australia.

International journal of stroke : official journal of the International Stroke Society, 2014, Volume: 9, Issue:1

Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Cohort Studies; Deglutition Disorders; Female;

2014

Risk of ischemic stroke associated with non-steroidal anti-inflammatory drugs and paracetamol: a population-based case-control study.

Journal of thrombosis and haemostasis : JTH, 2015, Volume: 13, Issue:5

Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischem

2015

Acetaminophen use and risk of myocardial infarction and stroke in a hypertensive cohort.

Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:5

Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Chronic Pain; Confounding Factors, Ep

2015

Should acetaminophen be added to the list of anti-inflammatory agents that are associated with cardiovascular events?

Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:5

Topics: Acetaminophen; Blood Pressure; Chronic Pain; Female; Humans; Hypertension; Male; Myocardial Infarcti

2015

Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke.

Stroke, 2016, Volume: 47, Issue:4

Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Brain Ischemia; Cardiovascular Diseases; Female; Hemo

2016

CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships.

PloS one, 2016, Volume: 11, Issue:6

Topics: Acetaminophen; Adult; Age of Onset; Aged; Aged, 80 and over; Analgesics; CADASIL; Codeine; Cross-Sec

2016

Letter by Iannuccelli et al Regarding Article, "Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke".

Stroke, 2016, Volume: 47, Issue:9

Topics: Acetaminophen; Brain Ischemia; Hemorrhage; Humans; Ibuprofen; Stroke

2016

Testing a systematic approach to identify and prioritise barriers to successful implementation of a complex healthcare intervention.

BMC medical research methodology, 2017, 02-07, Volume: 17, Issue:1

Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Australia; Emergency Medical Services; Emergency Ser

2017

Paracetamol for stroke: easy in practice, but not in trials.

The Lancet. Neurology, 2009, Volume: 8, Issue:5

Topics: Acetaminophen; Anti-Inflammatory Agents; Clinical Trials as Topic; Humans; Hypothermia, Induced; Str

2009

Confusion and stroke due to an "umbrella brand" product.

Prescrire international, 2008, Volume: 17, Issue:96

Topics: Acetaminophen; Canada; Diphenhydramine; Drug Combinations; Drug Labeling; France; Humans; Medication

2008

High-dose paracetamol in stroke: new trials are necessary and feasible.

The Lancet. Neurology, 2009, Volume: 8, Issue:8

Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Clinical Trials as Topic; Humans; Stroke

2009

[Antipyretic strategies for acute stroke: a nationwide survey among German stroke units].

Der Nervenarzt, 2010, Volume: 81, Issue:6

Topics: Acetaminophen; Analgesics, Non-Narcotic; Cryotherapy; Data Collection; Dipyrone; Germany; Hospitals,

2010

Endothelin-A receptor antagonist BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral ischemia in rats.

European journal of pharmacology, 2010, Oct-10, Volume: 644, Issue:1-3

Topics: Acetaminophen; Animals; Antipyretics; Brain Ischemia; Disease Models, Animal; Drug Synergism; Endoth

2010

An early rise in body temperature is related to unfavorable outcome after stroke: data from the PAIS study.

Journal of neurology, 2011, Volume: 258, Issue:2

Topics: Acetaminophen; Aged; Antipyretics; Female; Fever; Humans; Male; Multicenter Studies as Topic; Random

2011

Standardized antipyretic treatment in stroke: a pilot study.

Cerebrovascular diseases (Basel, Switzerland), 2011, Volume: 31, Issue:4

Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Body Temperature Regulation; Case-Control Stud

2011

Effective fever control in acute stroke: still wanted!

Cerebrovascular diseases (Basel, Switzerland), 2011, Volume: 31, Issue:4

Topics: Acetaminophen; Antipyretics; Body Temperature Regulation; Combined Modality Therapy; Dipyrone; Fever

2011

Effects of high-dose paracetamol on blood pressure in acute stroke.

Acta neurologica Scandinavica, 2012, Volume: 125, Issue:4

Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Blood Pressure; Blood Pressure Determination;

2012

[Does paracetamol improve recovery after stroke?].

Nederlands tijdschrift voor geneeskunde, 2011, Volume: 155, Issue:46

Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Fever; Hum

2011

Body temperature in acute stroke.

Stroke, 2002, Volume: 33, Issue:9

Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Body Temperature; Disease Progression; Fever; Huma

2002

Introduction to monitoring. What is what you prescribed actually doing?

Australian family physician, 2003, Volume: 32, Issue:10

Topics: Acetaminophen; Aged; Aspirin; Australia; Celecoxib; Drug Interactions; Drug Therapy, Combination; Fa

2003

Reduction of body temperature with paracetamol in patients with acute stroke: randomised clinical trials are needed.

Cerebrovascular diseases (Basel, Switzerland), 2004, Volume: 18, Issue:4

Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Fever; Hu

2004

PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial [ISCRTN 74418480].

BMC cardiovascular disorders, 2005, Aug-19, Volume: 5

Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Clinical Protocols; Double-Blind Method;

2005

The time course and determinants of temperature within the first 48 h after ischaemic stroke.

Cerebrovascular diseases (Basel, Switzerland), 2007, Volume: 24, Issue:1

Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Bacterial Infec

2007

Acetaminophen for temperature reduction in acute stroke: potential but unproven benefits.

Stroke, 2007, Volume: 38, Issue:11

Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Body Temperature; Clinical Trials as Topic;

2007

Drug absorption may be delayed after stroke: results of the paracetamol absorption test.

Age and ageing, 2001, Volume: 30, Issue:5

Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Gastric Emptying; Humans; Intestinal

2001

Modification of body temperature after acute stroke: a new concept needed?

Stroke, 2002, Volume: 33, Issue:1

Topics: Acetaminophen; Acute Disease; Body Temperature; Double-Blind Method; Fever; Humans; Hypothermia; Str

2002

PISA. The effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute stroke: protocol for a phase II double-blind randomised placebo-controlled trial [ISRCTN98608690].

BMC cardiovascular disorders, 2002, Mar-27, Volume: 2

Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Clinical Trials, Phase II

2002

Assessing the risks of cervical manipulation for neck pain.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2002, Apr-30, Volume: 166, Issue:9

Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cervical Vertebrae; Evidence-Based Medicine;

2002