acetaminophen has been researched along with Anoxemia in 26 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Hypoxia did not enhance the hepatotoxic response to paracetamol, allyl alcohol, bromobenzene or thioacetamide." | 7.66 | Influence of hypoxia on the hepatotoxic effects of carbon tetrachloride, paracetamol, allyl alcohol, bromobenzene and thioacetamide. ( Breining, H; Strubelt, O, 1980) |
| " Inflammation and fibrosis were evaluated by transaminases, myeloperoxidase activity, hydroxyproline, and histological evaluation." | 4.12 | Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease. ( Abrante, B; Abreu-González, P; de la Barreda, R; Díaz-Flores, F; González-Paredes, FJ; Hernández-Bustabad, A; Hernández-Guerra, M; Morales-Arraez, D; Quintero, E, 2022) |
| " Hypoxia did not enhance the hepatotoxic response to paracetamol, allyl alcohol, bromobenzene or thioacetamide." | 3.66 | Influence of hypoxia on the hepatotoxic effects of carbon tetrachloride, paracetamol, allyl alcohol, bromobenzene and thioacetamide. ( Breining, H; Strubelt, O, 1980) |
| "Recently, seizure-induced cyclooxygenase (COX)-mediated postictal vasoconstriction, accompanied by cerebral hypoperfusion and hypoxia, has been identified as a candidate mechanism in experimentally induced seizures in rats." | 3.11 | Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE). ( Hofmeijer, J; Pottkämper, JCM; van Putten, MJAM; van Waarde, JA; van Wingen, GA; Verdijk, JPAJ; Verwijk, E, 2022) |
| "Hypoxemia was defined as peripheral oxygen saturation less than 90%." | 2.94 | The relationship between postoperative opioid consumption and the incidence of hypoxemic events following total hip arthroplasty: a post hoc analysis. ( Borgeat, A; Camu, F; Cheung, R; Essex, MN; Pan, S; Salomon, PA, 2020) |
| "To test the hypothesis that duration of hypoxemia is less in patients given intravenous acetaminophen than those given placebo." | 2.94 | Effect of Intravenous Acetaminophen on Postoperative Hypoxemia After Abdominal Surgery: The FACTOR Randomized Clinical Trial. ( Ali Sakr Esa, W; Ayad, S; Cohen, B; Delaney, CP; Essber, H; Hovsepyan, K; Kessler, H; Maheshwari, K; Makarova, N; Mascha, EJ; Ruetzler, K; Saasouh, W; Sessler, DI; Soliman, LM; Turan, A; Yang, D, 2020) |
| " The absolute bioavailability of frusemide during hypoxaemia (0." | 2.68 | The effect of hypoxaemia on drug disposition in chronic respiratory failure. ( Hayball, PJ; Henderson, G; Latimer, K; May, F; Rowett, D; Ruffin, RE; Sansom, LN, 1996) |
| "Acetaminophen was found to increase the AUB with an estimated median difference of 15 (95% CI, 5-25) mm Hg × minutes (P = ." | 1.62 | Effect of Intravenous Acetaminophen on Mean Arterial Blood Pressure: A Post Hoc Analysis of the EFfect of Intravenous ACetaminophen on PosToperative HypOxemia After Abdominal SurgeRy Trial. ( AlGharrash, A; Bakal, O; Bravo, M; Essber, H; Mascha, EJ; Mosteller, L; Pu, X; Rivas, E; Rodriguez-Patarroyo, F; Turan, A, 2021) |
| "Deficits in this task following seizures were reversed by COX-2 inhibition, which prevented severe postictal hypoxia." | 1.56 | In vivo assessment of mechanisms underlying the neurovascular basis of postictal amnesia. ( Colangeli, R; Dickson, CT; Dudok, B; Farrell, JS; Jackson, J; Nguyen, SL; Soltesz, I; Teskey, GC; Wolff, MD, 2020) |
| "Hypoxic hepatitis is a clinical condition precipitated by prolonged periods of oxygen deprivation to the liver." | 1.46 | Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis. ( Antoine, DJ; Curry, SC; Jaeschke, H; Jenkins, RE; McGill, MR; Olson, JC; Sharpe, MR; Weemhoff, JL; Woolbright, BL, 2017) |
| "In contrast, symptoms and hypoxemia reappeared when minocycline was re-administered." | 1.34 | Minocycline-induced acute eosinophilic pneumonia: controversial results of lymphocyte stimulation test and re-challenge test. ( Ando, M; Kumamoto, T; Matsuno, O; Miyazaki, E; Nureki, S; Okubo, T; Ono, E, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.69) | 18.7374 |
| 1990's | 4 (15.38) | 18.2507 |
| 2000's | 5 (19.23) | 29.6817 |
| 2010's | 6 (23.08) | 24.3611 |
| 2020's | 9 (34.62) | 2.80 |
| Authors | Studies |
|---|---|
| Verdijk, JPAJ | 1 |
| Pottkämper, JCM | 1 |
| Verwijk, E | 1 |
| van Wingen, GA | 1 |
| van Putten, MJAM | 1 |
| Hofmeijer, J | 1 |
| van Waarde, JA | 1 |
| Hernández-Bustabad, A | 1 |
| Morales-Arraez, D | 1 |
| González-Paredes, FJ | 1 |
| Abrante, B | 1 |
| Díaz-Flores, F | 1 |
| Abreu-González, P | 1 |
| de la Barreda, R | 1 |
| Quintero, E | 1 |
| Hernández-Guerra, M | 1 |
| Gao, RY | 1 |
| Wang, M | 1 |
| Liu, Q | 1 |
| Feng, D | 1 |
| Wen, Y | 1 |
| Xia, Y | 1 |
| Colgan, SP | 1 |
| Eltzschig, HK | 1 |
| Ju, C | 2 |
| Essex, MN | 1 |
| Camu, F | 1 |
| Borgeat, A | 1 |
| Salomon, PA | 1 |
| Pan, S | 1 |
| Cheung, R | 1 |
| Schomaker, S | 1 |
| Potter, D | 1 |
| Warner, R | 1 |
| Larkindale, J | 1 |
| King, N | 1 |
| Porter, AC | 1 |
| Owens, J | 1 |
| Tomlinson, L | 1 |
| Sauer, JM | 1 |
| Johnson, K | 1 |
| Aubrecht, J | 1 |
| Turan, A | 2 |
| Essber, H | 2 |
| Saasouh, W | 1 |
| Hovsepyan, K | 1 |
| Makarova, N | 1 |
| Ayad, S | 1 |
| Cohen, B | 1 |
| Ruetzler, K | 1 |
| Soliman, LM | 1 |
| Maheshwari, K | 1 |
| Yang, D | 1 |
| Mascha, EJ | 2 |
| Ali Sakr Esa, W | 1 |
| Kessler, H | 1 |
| Delaney, CP | 1 |
| Sessler, DI | 1 |
| Farrell, JS | 1 |
| Colangeli, R | 1 |
| Dudok, B | 1 |
| Wolff, MD | 1 |
| Nguyen, SL | 1 |
| Jackson, J | 1 |
| Dickson, CT | 1 |
| Soltesz, I | 1 |
| Teskey, GC | 1 |
| Shankar, SR | 1 |
| Bravo, M | 1 |
| Bakal, O | 1 |
| Rivas, E | 1 |
| Pu, X | 1 |
| Mosteller, L | 1 |
| Rodriguez-Patarroyo, F | 1 |
| AlGharrash, A | 1 |
| You, Q | 1 |
| Holt, M | 1 |
| Yin, H | 1 |
| Li, G | 1 |
| Hu, CJ | 1 |
| Weemhoff, JL | 1 |
| Woolbright, BL | 1 |
| Jenkins, RE | 1 |
| McGill, MR | 1 |
| Sharpe, MR | 1 |
| Olson, JC | 1 |
| Antoine, DJ | 1 |
| Curry, SC | 1 |
| Jaeschke, H | 1 |
| Naik, P | 1 |
| Cashin, L | 1 |
| Huitron, S | 1 |
| Savransky, V | 2 |
| Reinke, C | 1 |
| Jun, J | 1 |
| Bevans-Fonti, S | 1 |
| Nanayakkara, A | 2 |
| Li, J | 3 |
| Myers, AC | 1 |
| Torbenson, MS | 2 |
| Polotsky, VY | 2 |
| Lavie, L | 1 |
| Chaudhuri, S | 1 |
| McCullough, SS | 1 |
| Hennings, L | 1 |
| Letzig, L | 1 |
| Simpson, PM | 1 |
| Hinson, JA | 1 |
| James, LP | 1 |
| Nath, B | 1 |
| Szabo, G | 1 |
| Zhang, D | 1 |
| Ward, KM | 1 |
| Prendergast, GC | 1 |
| Ayene, IS | 1 |
| Rork, TH | 1 |
| Van Dyke, K | 1 |
| Spiler, NM | 1 |
| Merrill, GF | 1 |
| Vivero, A | 1 |
| Bevans, S | 1 |
| Smith, PL | 1 |
| Ono, E | 1 |
| Miyazaki, E | 1 |
| Matsuno, O | 1 |
| Nureki, S | 1 |
| Okubo, T | 1 |
| Ando, M | 1 |
| Kumamoto, T | 1 |
| Strubelt, O | 1 |
| Breining, H | 1 |
| Bonkovsky, HL | 1 |
| Rowett, D | 1 |
| Latimer, K | 1 |
| Sansom, LN | 1 |
| Ruffin, RE | 1 |
| May, F | 1 |
| Henderson, G | 1 |
| Hayball, PJ | 1 |
| McKie, AT | 1 |
| Simpson, RJ | 1 |
| Ghosh, S | 1 |
| Peters, TJ | 1 |
| Farzaneh, F | 1 |
| Aw, TY | 1 |
| Shan, XQ | 1 |
| Sillau, AH | 1 |
| Jones, DP | 1 |
| Chalstrey, LJ | 1 |
| Parbhoo, SP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| StudY of Effect of Nimodipine and Acetaminophen on Postictal Symptoms After ECT[NCT04028596] | Phase 2 | 34 participants (Actual) | Interventional | 2019-12-05 | Completed | ||
| Effect of Intravenous Acetaminophen on Postoperative Opioid-related Complications[NCT02156154] | Phase 3 | 580 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| Use of IV Acetaminophen Intraoperatively in Obese Patients at Risk for Obstructive Sleep Apnea Undergoing Laparoscopic Cholecystectomy[NCT02056678] | Phase 4 | 0 participants (Actual) | Interventional | 2014-02-28 | Withdrawn (stopped due to Investigator left institution) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Hypoxemia is measured as minutes with hypoxemia (Spo2 <90%) per hour of successful Spo2 monitoring. Patients will have nearly continuous pulseoximeter monitoring and recording. Data from the monitor will be downloaded daily for 48 hours postoperatively. (NCT02156154)
Timeframe: the initial 48 hours of postoperative monitoring or for the duration of hospitalization, if shorter.
| Intervention | min/h (Median) |
|---|---|
| Intravenous Acetaminophen | 0.7 |
| Intravenous 0.9% Sodium Chloride | 1.1 |
Fatigue scores were calculated on a scale of 1 to 10, with 1 being no fatigue and 10 being the worst fatigue imaginable. (NCT02156154)
Timeframe: Postoperative day 1
| Intervention | score on a scale (Mean) |
|---|---|
| Intravenous Acetaminophen | 5 |
| Intravenous 0.9% Sodium Chloride | 4.9 |
A low respiratory function event was defined as an episode of less than 40% of predicted minute ventilation for 2 minutes. (NCT02156154)
Timeframe: Initial 48 postoperative hours or duration of hospitalization (whichever comes first)
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Acetaminophen | 52 |
| Intravenous 0.9% Sodium Chloride | 50 |
Patients were asked about postoperative nausea and vomiting in the postanesthesia care unit, at 4-hour intervals while awake through the remaining initial day of surgery, and on the first and second postoperative mornings. (NCT02156154)
Timeframe: Initial 48 postoperative hours or duration of hospitalization (whichever comes first)
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Acetaminophen | 140 |
| Intravenous 0.9% Sodium Chloride | 124 |
Sedation was estimated by the RASS score and recorded at 2-hour intervals by ward nurses per clinical routine during the initial 48 postoperative hours. The Richmond Agitation-Sedation Scale (RASS) is scored from -5 to +4, with -5 being unarousable, 0 being alert and calm, and +4 being combative. (NCT02156154)
Timeframe: Initial 48 postoperative hours or duration of hospitalization (whichever comes first)
| Intervention | score on a scale (Mean) |
|---|---|
| Intravenous Acetaminophen | -0.96 |
| Intravenous 0.9% Sodium Chloride | -0.89 |
Total opioid consumption over the initial 48 postoperative hours was extracted from patients' medical records and converted to intravenous morphine equivalents (NCT02156154)
Timeframe: Initial 48 postoperative hours
| Intervention | mg (Median) |
|---|---|
| Intravenous Acetaminophen | 50 |
| Intravenous 0.9% Sodium Chloride | 58 |
Treatment effect data are reported as ratios of geometric means (NCT02156154)
Timeframe: Initial 48 postoperative hours or duration of hospitalization (whichever comes first)
| Intervention | hours (Median) |
|---|---|
| Intravenous Acetaminophen | 2.2 |
| Intravenous 0.9% Sodium Chloride | 2.2 |
Pain scores were calculated on a visual analog scale of 0 to 10, with 0 being no pain and 10 being the most pain imaginable; time-weighted mean was calculated as the area under the curve of the pain score measurements divided by total measurement time. (NCT02156154)
Timeframe: Initial 48 postoperative hours or duration of hospitalization (whichever comes first)
| Intervention | score on a scale (Mean) |
|---|---|
| Intravenous Acetaminophen | 4.3 |
| Intravenous 0.9% Sodium Chloride | 4.4 |
Pain scores were calculated on a visual analog scale of 0 to 10, with 0 being no pain and 10 being the most pain imaginable; time weighted mean was calculated as the area under the curve of the pain score measurements divided by total measurement time. Pain was recorded at roughly 15-minute intervals in the postanesthesia care unit and at 4-hour intervals on surgical wards (NCT02156154)
Timeframe: Initial 48 postoperative hours or duration of hospitalization (whichever comes first)
| Intervention | score on a scale (Mean) |
|---|---|
| Intravenous Acetaminophen | 4.2 |
| Intravenous 0.9% Sodium Chloride | 4.4 |
Total anesthetic dose is measured in minimal alveolar concentration hours. (NCT02156154)
Timeframe: Induction to extubation (3 hours on average)
| Intervention | minimal alveolar concentration hours (Median) |
|---|---|
| Intravenous Acetaminophen | 2.9 |
| Intravenous 0.9% Sodium Chloride | 2.9 |
1 review available for acetaminophen and Anoxemia
| Article | Year |
|---|---|
Hypoxia and hypoxia inducible factors: diverse roles in liver diseases.
Topics: Acetaminophen; Animals; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Immunity, Innate; Lipid Metabol | 2012 |
4 trials available for acetaminophen and Anoxemia
| Article | Year |
|---|---|
Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE).
Topics: Acetaminophen; Animals; Depressive Disorder, Major; Electroconvulsive Therapy; Electroencephalograph | 2022 |
The relationship between postoperative opioid consumption and the incidence of hypoxemic events following total hip arthroplasty: a post hoc analysis.
Topics: Acetaminophen; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Arthropla | 2020 |
Effect of Intravenous Acetaminophen on Postoperative Hypoxemia After Abdominal Surgery: The FACTOR Randomized Clinical Trial.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Female; Humans; Hy | 2020 |
The effect of hypoxaemia on drug disposition in chronic respiratory failure.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Biological Availability; Chronic Disease; Cros | 1996 |
21 other studies available for acetaminophen and Anoxemia
| Article | Year |
|---|---|
Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease.
Topics: Acetaminophen; Acetylcholine; Animals; Hydroxyproline; Hypoxia; Inflammation; Intercellular Adhesion | 2022 |
Hypoxia-Inducible Factor-2α Reprograms Liver Macrophages to Protect Against Acute Liver Injury Through the Production of Interleukin-6.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell | 2020 |
Serum glutamate dehydrogenase activity enables early detection of liver injury in subjects with underlying muscle impairments.
Topics: Acetaminophen; Adolescent; Adult; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomar | 2020 |
In vivo assessment of mechanisms underlying the neurovascular basis of postictal amnesia.
Topics: Acetaminophen; Amnesia; Animals; CA1 Region, Hippocampal; Hippocampus; Hypoxia; Long-Term Potentiati | 2020 |
Intravenous Acetaminophen in Postoperative Patients.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Humans; Hypoxia | 2020 |
Effect of Intravenous Acetaminophen on Mean Arterial Blood Pressure: A Post Hoc Analysis of the EFfect of Intravenous ACetaminophen on PosToperative HypOxemia After Abdominal SurgeRy Trial.
Topics: Abdomen; Acetaminophen; Administration, Intravenous; Adult; Aged; Analgesics, Non-Narcotic; Blood Pr | 2021 |
Role of hepatic resident and infiltrating macrophages in liver repair after acute injury.
Topics: Acetaminophen; Animals; Cell Movement; Cell Proliferation; Chemical and Drug Induced Liver Injury; E | 2013 |
Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis.
Topics: Acetaminophen; Adolescent; Adult; Alanine Transaminase; Apoptosis; Biomarkers; DNA Fragmentation; DN | 2017 |
A Case of Pulmonary Foreign Body Granulomatosis Secondary to Intravenous Injection of Acetaminophen/Oxycodone.
Topics: Acetaminophen; Administration, Intravenous; Adult; Drug Combinations; Granuloma, Foreign-Body; Hemop | 2016 |
Chronic intermittent hypoxia and acetaminophen induce synergistic liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; As | 2009 |
Obstructive sleep apnoea and acetaminophen safety - is the liver at risk?
Topics: Acetaminophen; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and | 2009 |
Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; | 2011 |
Hydroxyethyl disulfide as an efficient metabolic assay for cell viability in vitro.
Topics: Acetaminophen; Arsenicals; Arsenites; Biological Assay; Cell Line, Tumor; Cell Proliferation; Cell S | 2012 |
Acetaminophen in the hypoxic and reoxygenated guinea pig myocardium.
Topics: Acetaminophen; Animals; Cardiotonic Agents; Guinea Pigs; Heart; Hypoxia; Microscopy, Electron, Trans | 2004 |
Chronic intermittent hypoxia predisposes to liver injury.
Topics: Acetaminophen; Animals; Blood Glucose; Cytokines; Hypoxia; Insulin; Lipid Metabolism; Lipid Peroxida | 2007 |
Minocycline-induced acute eosinophilic pneumonia: controversial results of lymphocyte stimulation test and re-challenge test.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Bacterial Agents; False Negative Reacti | 2007 |
Influence of hypoxia on the hepatotoxic effects of carbon tetrachloride, paracetamol, allyl alcohol, bromobenzene and thioacetamide.
Topics: Acetaminophen; Allyl Compounds; Animals; Bromobenzenes; Carbon Tetrachloride; Ethanol; Hemodynamics; | 1980 |
Acetaminophen hepatotoxicity, fasting, and ethanol.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Hypoxia; Liver; Risk Factors | 1995 |
Regulation of pancreatitis-associated protein (HIP/PAP) mRNA levels in mouse pancreas and small intestine.
Topics: Acetaminophen; Acute-Phase Proteins; Analgesics, Non-Narcotic; Animals; Antigens, Neoplasm; Biomarke | 1996 |
Effect of chronic hypoxia on acetaminophen metabolism in the rat.
Topics: Acetaminophen; Animals; Glucuronates; Glutathione; Half-Life; Hypoxia; In Vitro Techniques; Male; Me | 1991 |
Circuitry and technique of extracorporeal porcine liver perfusion for the treatment of hepatic coma.
Topics: Acetaminophen; Acute Disease; Animals; Extracorporeal Circulation; Fatty Liver; Hepatic Encephalopat | 1971 |