acetaminophen has been researched along with Anasarca in 74 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Excerpt | Relevance | Reference |
---|---|---|
"According to these results, diclofenac and paracetamol had the same effect on pain reduction of ankle sprains but more acute ankle edema was present in patients who were treated with diclofenac than in patients who were treated with paracetamol." | 9.15 | Efficacy of paracetamol versus diclofenac for Grade II ankle sprains. ( Lyrtzis, C; Natsis, K; Noussios, G; Papadopoulos, C; Papathanasiou, E, 2011) |
"To compare acetaminophen extended release 1,300 mg 3 times daily and ibuprofen 400 mg 3 times daily for treatment of signs and symptoms of grade I or II lateral ankle sprains." | 9.12 | Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains. ( Dalton, JD; Schweinle, JE, 2006) |
"In a double-blind crossover study, the clinical anti-oedematous efficacy was compared of a weak cyclooxygenase inhibitor oxindanac 200 mg thrice daily in a controlled clinical trial procedure with paracetamol 1 g thrice daily as a positive control involving objective measurement of acute soft tissue oedema." | 9.06 | The anti-oedematous efficacy of oxindanac equals that of paracetamol in acute postoperative inflammation; are weak cyclooxygenase inhibitors more effective than strong inhibitors? ( Eidsaunet, W; Pettersen, N; Skoglund, LA, 1989) |
"According to these results, diclofenac and paracetamol had the same effect on pain reduction of ankle sprains but more acute ankle edema was present in patients who were treated with diclofenac than in patients who were treated with paracetamol." | 5.15 | Efficacy of paracetamol versus diclofenac for Grade II ankle sprains. ( Lyrtzis, C; Natsis, K; Noussios, G; Papadopoulos, C; Papathanasiou, E, 2011) |
"To compare acetaminophen extended release 1,300 mg 3 times daily and ibuprofen 400 mg 3 times daily for treatment of signs and symptoms of grade I or II lateral ankle sprains." | 5.12 | Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains. ( Dalton, JD; Schweinle, JE, 2006) |
"In a double-blind crossover study, the clinical anti-oedematous efficacy was compared of a weak cyclooxygenase inhibitor oxindanac 200 mg thrice daily in a controlled clinical trial procedure with paracetamol 1 g thrice daily as a positive control involving objective measurement of acute soft tissue oedema." | 5.06 | The anti-oedematous efficacy of oxindanac equals that of paracetamol in acute postoperative inflammation; are weak cyclooxygenase inhibitors more effective than strong inhibitors? ( Eidsaunet, W; Pettersen, N; Skoglund, LA, 1989) |
" Nevertheless, the anti-inflammatory activity was tested in carrageenan induced paw edema and histamine induced inflammatory tests." | 3.78 | Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. ( Khan, H; Muhammad, N; Saeed, M, 2012) |
" Among the 12 prepared compounds, Compounds 3d, e, i and j exhibited significant anti-inflammatory activity in model of acute inflammation such as carrageenan-induced rat edema paw while compounds 3d and e showed considerable activity in model of chronic inflammation such as adjuvant-induced arthritis and were compared with diclofenac (13." | 3.75 | Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents. ( Aragade, P; Khode, S; Maddi, V; Mamledesai, S; Palkar, M; Ronad, PK; Satyanarayana, D; Thippeswamy, AH, 2009) |
"Dipyrone blocked carrageenin-induced oedema and hyperalgesia in a dose-dependent manner." | 3.67 | Mode of analgesic action of dipyrone: direct antagonism of inflammatory hyperalgesia. ( Ferreira, SH; Lorenzetti, BB, 1985) |
"The antinociceptive properties of suprofen [alpha-methyl-4-(thienylcarbonyl)benzene acetic acid] are described in a pathologically induced hyperalgesic model, the rat adjuvant arthritis flexion test." | 3.66 | Suprofen, a new peripheral analgesic. ( Capetola, RJ; Rosenthale, ME; Shriver, DA, 1980) |
"Dexamethasone also reduced postoperative pain after LITM surgical extraction significantly on postoperative days 2 and 7." | 2.77 | Effect of single dose preoperative intramuscular dexamethasone injection on lower impacted third molar surgery. ( Boonsiriseth, K; Kaewpradub, P; Klongnoi, B; Wongsirichat, N, 2012) |
"Significant differences in postoperative pain intensity were detected between the drug combinations at 4, 6, and 12p." | 2.77 | Comparative study of tramadol combined with dexamethasone and diclofenac sodium in third-molar surgery. ( Brandão, JR; da Silva, LC; de Assunção Oliveira, AC; de Santana Santos, T; de Sousa Santos, JA; Menezes Júnior, LR, 2012) |
"In summary, pain, trismus and swelling after lower third molar extraction, independent of surgical difficulty, could be controlled by piroxicam 20mg administered orally or sublingually and no significant differences were observed between the route of delivery used in this study." | 2.76 | Comparison of oral versus sublingual piroxicam during postoperative pain management after lower third molar extraction. ( Brozoski, DT; Calvo, AM; Colombini-Ishikiriama, BL; Dionísio, TJ; Faria, FA; Giglio, FP; Lauris, JR; Modena, KC; Ribeiro, DA; Santos, CF; Trindade, PA, 2011) |
"The authors assessed the participants' postoperative pain by means of a visual analog scale at four, six, eight, 12, 24 and 48 hours." | 2.76 | Evaluation of the muscle relaxant cyclobenzaprine after third-molar extraction. ( Calazans, AC; de Oliveira E Silva, ED; de Santana Santos, T; Gomes, AC; Martins-Filho, PR; Silva, LC, 2011) |
"Pain, swelling, infection, trismus and temperature were recorded on days 3, 7 and 14 after surgery." | 2.75 | Antibiotic prophylaxis in third molar surgery: A randomized double-blind placebo-controlled clinical trial using split-mouth technique. ( Morkel, JA; Siddiqi, A; Zafar, S, 2010) |
" Mild-to-moderate adverse effects were reported." | 2.74 | A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model. ( Chopra, D; Kakkar, AK; Mehra, P; Rehan, HS, 2009) |
"On the second postoperative day, facial edema showed a statistically significant reduction in both dexamethasone 4-mg and dexamethasone 8-mg groups compared with the control group, but no statistically significant differences were observed between the 2 dosage regimens of dexamethasone." | 2.73 | Effect of submucosal injection of dexamethasone on postoperative discomfort after third molar surgery: a prospective study. ( Beretta, M; Borgonovo, A; Farronato, D; Garramone, RA; Grossi, GB; Maiorana, C; Santoro, F, 2007) |
"Naproxen was statistically superior (p < or = 0." | 2.71 | Naproxen 500 mg bid versus acetaminophen 1000 mg qid: effect on swelling and other acute postoperative events after bilateral third molar surgery. ( Bjørnsson, GA; Haanaes, HR; Skoglund, LA, 2003) |
"Trismus was determined by measuring maximum interincisal opening and facial swelling was evaluated using a tape measuring method." | 2.71 | Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery. ( Erdogan, O; Esen, E; Karsli, ED; UStün, Y, 2003) |
"Naproxen treatment, irrespective of type of operation, did not require rescue analgesics, while two patients after CTS treated with paracetamol did." | 2.70 | Acute postoperative swelling after hand surgery: an exploratory, double-blind, randomised study with paracetamol, naproxen, and placebo. ( Fyllingen, G; Haugstvedt, JR; Husby, T; Skoglund, LA, 2001) |
"The profiles of postoperative pain in the two groups were similar from the first postoperative day, but Ibumetin was better pain reliever on the day of surgery." | 2.67 | Pain control after third molar surgery--a comparative study of ibuprofen (Ibumetin) and a paracetamol/codeine combination (Citodon). ( Anzén, B; Lysell, L, 1992) |
" Intraperitoneal or po administration of the new chemical entities (NCEs), 3b and 3r, in concentrations equal to a toxic dose of ApAP did not result in the formation of NAPQI." | 1.56 | A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis. ( Abet, V; Alvarez-Builla, J; Bazan, HA; Bazan, NG; Bhattacharjee, S; Burgos, C; Edwards, S; Gordon, WC; Heap, J; Jun, B; Ledet, AJ; Pahng, AR; Paul, D; Recio, J, 2020) |
" Plasma samples were collected at 17 hr after dosing (during the manifestation of symptoms) and at one month (after recovery) and were subjected to LC-MS analysis of NAPQI-adducts." | 1.51 | LC-MS analyses of N-acetyl-p-benzoquinone imine-adducts of glutathione, cysteine, N-acetylcysteine, and albumin in a plasma sample: A case study from a patient with a rare acetaminophen-induced acute swelling rash. ( Kubo, T; Lee, SH; Oe, T; Ozawa, M, 2019) |
"Outcome measures were postsurgical pain at rest and during walking, consumption of opioids for pain rescue, knee swelling and knee range of motion, and complications." | 1.46 | Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty. ( Hansen, TB; Munk, S; Rytter, S; Stilling, M, 2017) |
"Paracetamol is regarded as a relatively safe drug in the gastro-duodenal region of humans but recent epidemiological investigations have suggested that at high doses there may be an increased risk of ulcers and bleeding." | 1.33 | Paracetamol [acetaminophen]-induced gastrotoxicity: revealed by induced hyperacidity in combination with acute or chronic inflammation. ( Rainsford, KD; Whitehouse, MW, 2006) |
"Gemcitabine is a nucleosid analog approved for use in the treatment of metastatic urothelial carcinoma of the bladder." | 1.32 | Gemcitabine-associated scleroderma-like changes of the lower extremities. ( Bessis, D; Guilhou, JJ; Guillot, B; Legouffe, E, 2004) |
"Pain, swelling and trismus were the commonest complaints." | 1.31 | Postoperative complaints following impacted mandibular third molar surgery in Ile-Ife, Nigeria. ( Assam, E; Oginni, FO; Ogunbodede, EO; Ugboko, VI, 2002) |
" However, pain intensity scores indicate that APAP double dose gave less analgesia toward the end of the dosing interval than the standard regimen." | 1.28 | Effects of acetaminophen after bilateral oral surgery: double dose twice daily versus standard dose four times daily. ( Pettersen, N; Skoglund, LA, 1991) |
"A strong interrelation between postoperative pain and trismus indicates pain as the main reason for reduced mouth opening after removal of impacted mandibular third molars." | 1.27 | Interrelation of complaints after removal of impacted mandibular third molars. ( Pedersen, A, 1985) |
"Marked cyanosis was observed in experimental cats within 4 hours after administration of one 325-mg tablet." | 1.25 | Acetaminophen toxicosis in the cat. ( Duncan, JR; Finco, DC; Prasse, KW; Schall, WD, 1975) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 22 (29.73) | 18.7374 |
1990's | 5 (6.76) | 18.2507 |
2000's | 25 (33.78) | 29.6817 |
2010's | 21 (28.38) | 24.3611 |
2020's | 1 (1.35) | 2.80 |
Authors | Studies |
---|---|
Khode, S | 1 |
Maddi, V | 1 |
Aragade, P | 1 |
Palkar, M | 1 |
Ronad, PK | 1 |
Mamledesai, S | 1 |
Thippeswamy, AH | 1 |
Satyanarayana, D | 1 |
Eissa, AA | 1 |
Farag, NA | 1 |
Soliman, GA | 1 |
Palkar, MB | 1 |
Singhai, AS | 1 |
Ronad, PM | 1 |
Vishwanathswamy, AH | 1 |
Boreddy, TS | 1 |
Veerapur, VP | 1 |
Shaikh, MS | 1 |
Rane, RA | 1 |
Karpoormath, R | 1 |
Bazan, HA | 1 |
Bhattacharjee, S | 1 |
Burgos, C | 1 |
Recio, J | 1 |
Abet, V | 1 |
Pahng, AR | 1 |
Jun, B | 1 |
Heap, J | 1 |
Ledet, AJ | 1 |
Gordon, WC | 1 |
Edwards, S | 1 |
Paul, D | 1 |
Alvarez-Builla, J | 1 |
Bazan, NG | 1 |
Theodosis-Nobelos, P | 1 |
Athanasekou, C | 1 |
Rekka, EA | 1 |
Gilissen, L | 1 |
Mertens, S | 1 |
Goossens, A | 1 |
Bullens, D | 1 |
Morren, MA | 1 |
Guedes, KMM | 1 |
Borges, RS | 1 |
Fontes-Júnior, EA | 1 |
Silva, ASB | 1 |
Fernandes, LMP | 1 |
Cartágenes, SC | 1 |
Pinto, ACG | 1 |
Silva, ML | 1 |
Queiroz, LMD | 1 |
Vieira, JLF | 1 |
Sousa, PJC | 1 |
Maia, CSF | 1 |
Kadı, MR | 1 |
Hepgüler, S | 1 |
Atamaz, FC | 1 |
Dede, E | 1 |
Aydoğdu, S | 1 |
Aktuglu, K | 1 |
Ozkayın, N | 1 |
Ozturk, C | 1 |
Ozawa, M | 1 |
Kubo, T | 1 |
Lee, SH | 1 |
Oe, T | 1 |
Rytter, S | 1 |
Stilling, M | 1 |
Munk, S | 1 |
Hansen, TB | 1 |
Hatton, J | 1 |
Walsh, S | 1 |
Wilson, A | 1 |
Eroglu, CN | 1 |
Ataoglu, H | 1 |
Yildirim, G | 1 |
Kiresi, D | 1 |
Stewart, JE | 1 |
Haslam, AK | 1 |
Puig, J | 1 |
Kan, E | 1 |
Coelho, MS | 1 |
Reside, J | 1 |
Card, SJ | 1 |
Tawil, PZ | 1 |
Fry, R | 1 |
Ring, P | 1 |
Chopra, D | 1 |
Rehan, HS | 1 |
Mehra, P | 1 |
Kakkar, AK | 1 |
Siddiqi, A | 1 |
Morkel, JA | 1 |
Zafar, S | 1 |
Ghorab, MM | 1 |
Ismail, ZH | 1 |
Abdalla, M | 1 |
Trindade, PA | 1 |
Giglio, FP | 1 |
Colombini-Ishikiriama, BL | 1 |
Calvo, AM | 1 |
Modena, KC | 1 |
Ribeiro, DA | 1 |
Dionísio, TJ | 1 |
Brozoski, DT | 1 |
Lauris, JR | 1 |
Faria, FA | 1 |
Santos, CF | 1 |
Hey, M | 1 |
Wilson, I | 1 |
Johnson, MI | 1 |
Lyrtzis, C | 1 |
Natsis, K | 1 |
Papadopoulos, C | 1 |
Noussios, G | 1 |
Papathanasiou, E | 1 |
de Santana Santos, T | 2 |
Calazans, AC | 1 |
Martins-Filho, PR | 1 |
Silva, LC | 1 |
de Oliveira E Silva, ED | 1 |
Gomes, AC | 1 |
Brunet-Possenti, F | 1 |
Franck, N | 1 |
Tamburini, J | 1 |
Jacobelli, S | 1 |
Avril, MF | 1 |
Dupin, N | 1 |
Klongnoi, B | 1 |
Kaewpradub, P | 1 |
Boonsiriseth, K | 1 |
Wongsirichat, N | 1 |
de Sousa Santos, JA | 1 |
da Silva, LC | 1 |
Menezes Júnior, LR | 1 |
de Assunção Oliveira, AC | 1 |
Brandão, JR | 1 |
Muhammad, N | 1 |
Saeed, M | 1 |
Khan, H | 1 |
Nusstein, JM | 1 |
Reader, A | 4 |
Beck, M | 4 |
Oginni, FO | 1 |
Ugboko, VI | 1 |
Assam, E | 1 |
Ogunbodede, EO | 1 |
Bjørnsson, GA | 2 |
Haanaes, HR | 2 |
Skoglund, LA | 6 |
Allen, AL | 1 |
UStün, Y | 1 |
Erdogan, O | 1 |
Esen, E | 1 |
Karsli, ED | 1 |
Bessis, D | 1 |
Guillot, B | 1 |
Legouffe, E | 1 |
Guilhou, JJ | 1 |
Mannarino, E | 1 |
Lupattelli, G | 1 |
Schillaci, G | 1 |
Yadav, MR | 1 |
Nimekar, DM | 1 |
Ananthakrishnan, A | 1 |
Brahmkshatriya, PS | 1 |
Shirude, ST | 1 |
Giridhar, R | 1 |
Parmar, A | 1 |
Balaraman, R | 1 |
Rainsford, KD | 1 |
Whitehouse, MW | 1 |
Dalton, JD | 1 |
Schweinle, JE | 1 |
Grossi, GB | 1 |
Maiorana, C | 1 |
Garramone, RA | 1 |
Borgonovo, A | 1 |
Beretta, M | 1 |
Farronato, D | 1 |
Santoro, F | 1 |
Al-Khateeb, TH | 1 |
Nusair, Y | 1 |
Capetola, RJ | 1 |
Shriver, DA | 1 |
Rosenthale, ME | 1 |
Løkken, P | 1 |
Skjelbred, P | 1 |
Robak, J | 1 |
Kostka-Trabka, E | 1 |
Duniec, Z | 1 |
Ibáñez, MD | 1 |
Alonso, E | 1 |
Muñoz, MC | 1 |
Martinez, E | 1 |
Laso, MT | 1 |
Cechinel-Filho, V | 1 |
Vaz, ZR | 1 |
Zunino, L | 1 |
Calixto, JB | 1 |
Yunes, RA | 1 |
al-Swayeh, OA | 1 |
Futter, LE | 1 |
Clifford, RH | 1 |
Moore, PK | 1 |
Husby, T | 1 |
Haugstvedt, JR | 1 |
Fyllingen, G | 1 |
Nist, E | 1 |
Pickenpaugh, L | 1 |
Meyers, WJ | 1 |
Peterson, LJ | 1 |
Henry, M | 1 |
Duffy, JC | 1 |
Dearden, JC | 1 |
Rostron, C | 1 |
Alloui, A | 1 |
Chassaing, C | 1 |
Schmidt, J | 1 |
Ardid, D | 1 |
Dubray, C | 1 |
Cloarec, A | 1 |
Eschalier, A | 1 |
Hutchinson, D | 1 |
Witt, S | 1 |
Fairpo, CG | 1 |
Orton, D | 1 |
Schuurmans, D | 1 |
Vincent, JE | 1 |
Bruinvels, J | 1 |
Bonta, IL | 1 |
Frankhof, W | 1 |
Thiemer, K | 1 |
Piperno, E | 1 |
Mosher, AH | 1 |
Berssenbruegge, DA | 1 |
Winkler, JD | 1 |
Smith, RB | 1 |
Sveen, K | 1 |
Gilhuus-Moe, O | 1 |
Finco, DC | 1 |
Duncan, JR | 1 |
Schall, WD | 1 |
Prasse, KW | 1 |
John, B | 1 |
Chakrapani, A | 1 |
Sanklecha, M | 1 |
Kher, AS | 1 |
Bharucha, BA | 1 |
Kumta, NB | 1 |
Lysell, L | 1 |
Anzén, B | 1 |
Pettersen, N | 2 |
Mburu, DN | 2 |
Eidsaunet, W | 1 |
Bhattacharya, SK | 1 |
Rao, PJ | 1 |
Das Gupta, G | 1 |
Lorenzetti, BB | 1 |
Ferreira, SH | 1 |
Aghababian, RV | 1 |
Mbugua, SW | 1 |
Lökken, P | 1 |
Pedersen, A | 1 |
Davis, MR | 1 |
Flower, R | 1 |
Gryglewski, R | 1 |
Herbaczyńska-Cedro, K | 1 |
Vane, JR | 1 |
Becker, GL | 1 |
Cohen, S | 1 |
Borer, R | 1 |
Kalbhen, DA | 1 |
Fischer, W | 1 |
Leyland, A | 1 |
Pereira, G | 1 |
Padovan, G | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
The Effect of Preoperative Steroids Injection on Pain and Oedema After Total Knee Arthroplasty . A Double -Blinded Randomized Controlled Study.[NCT04084912] | Phase 3 | 86 participants (Anticipated) | Interventional | 2020-01-01 | Not yet recruiting | ||
Efficacy of Steroids on Functional Outcomes After Musculoskeletal Injuries of the Hand[NCT05003596] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
Effect on Initial Endodontic Treatment on Postoperative Pain in Symptomatic Teeth With Pulpal Necrosis[NCT01870973] | 108 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
Assessment of the Operative Course in Connection With Removal of Lower Third Molars With Particular Consideration to the Occurence of Pain and Swelling[NCT00805298] | 154 participants (Actual) | Interventional | 2008-08-31 | Completed | |||
Evaluation of the Effectiveness of the Use of the Therapeutic Bandage Method in Third Molar Surgery. Splint-mouth Randomized Blind Controlled Clinical Trial[NCT03393533] | 7 participants (Actual) | Interventional | 2017-10-20 | Completed | |||
Topical Hydrocortisone for Pain and Edema Control After Third Molar Surgery: a Clinical, Crossover, Randomized, Double-blind, Controlled Study[NCT03179813] | Phase 4 | 40 participants (Anticipated) | Interventional | 2017-05-01 | Completed | ||
A Randomized, Double-Blind, Parallel-Group Study Comparing the Safety and Effectiveness of Acetaminophen Extended Release (3900 mg/Day) and Ibuprofen (1200 mg/Day) in the Treatment of Ankle Sprains.[NCT00261560] | Phase 4 | 260 participants (Actual) | Interventional | Completed | |||
Effect of Preoperative, Single-dose Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Double-Blind Randomized Controlled Trial.[NCT03033147] | 72 participants (Actual) | Interventional | 2019-10-18 | Completed | |||
Effect of Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Randomized Controlled Trial[NCT03007342] | 78 participants (Anticipated) | Interventional | 2017-01-31 | Not yet recruiting | |||
Oral Versus Intravenous Acetaminophen for Postoperative Pain Management After Oocyte Retrieval Procedure. A Double Blinded, Placebo Controlled, Randomized Clinical Trial[NCT04662567] | 42 participants (Actual) | Interventional | 2021-03-12 | Terminated (stopped due to It was determined that the study should not continue as the study drug, Acetaminophen, could only be mixed in a solvent that would not allow the patients to be NPO prior to procedure.) | |||
Antagonism Research Between Antiemetics Agents (Droperidol, Dexametasone, Ondansetron) and Acetaminophen in Thyroidectomy's Post-operative Analgesia.[NCT01679093] | Phase 3 | 66 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
A Prospective, Multicenter Study Comparing Healing After Treatment With the Sonendo GentleWave™ System as Compared to a Traditional Root Canal Therapy Literature Control[NCT02285595] | 69 participants (Actual) | Interventional | 2014-07-31 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"pain measurement as assessed on a visual analog scale and pain medication usage~definition of success = no or mild pain as analyzed on VAS scale and no narcotic use; analyzed by logistic regression~VAS scale is 0 to 170 mm with the higher numbers indicating more pain and less success." (NCT01870973)
Timeframe: each day for 5 days
Intervention | percentage of participants (Number) |
---|---|
Root Canal Treatment | 52 |
no Root Canal Treatment | 43 |
"The periapical index: A scoring system for radiographic assessment of apical periodontitis. Score of 1: Normal. Score of 2: Small changes in bone structure. Score of 3: Changes in bone structure with some mineral loss (bone loss). Score of 4: Periodontitis with well-defined radiolucent area (apical periodontitis). Score of 5: Severe Periodontitis with exacerbating features (apical periodontitis).~Healed is defined by absence of a radiographic indication of apical periodontitis (PAI <3) and absence of clinical signs and symptoms other than tenderness to percussion.~Healing is defined by a reduction of radiolucency (if radiolucency is present at Baseline) combined with the absence of clinical signs and symptoms other than tenderness to percussion." (NCT02285595)
Timeframe: 12 months
Intervention | Participants (Count of Participants) | ||
---|---|---|---|
PAI Score < 3 | PAI Score = 3 | PAI Score 4 or 5 | |
GentleWave™ Treatment Group | 51 | 3 | 0 |
1 review available for acetaminophen and Anasarca
Article | Year |
---|---|
Focal rituximab-induced edematous reaction at primary cutaneous follicle center lymphoma lesions: case report and literature review.
Topics: Acetaminophen; Adult; Anti-Allergic Agents; Antibodies, Monoclonal, Murine-Derived; Antineoplastic A | 2011 |
27 trials available for acetaminophen and Anasarca
Article | Year |
---|---|
Is interferential current effective in the management of pain, range of motion, and edema following total knee arthroplasty surgery? A randomized double-blind controlled trial.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Arthroplasty, Replacement, Knee; Double-Blind Method; | 2019 |
Periapical Microsurgery: The Effects of Locally Injected Dexamethasone on Pain, Swelling, Bruising, and Wound Healing.
Topics: Acetaminophen; Adrenal Cortex Hormones; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthe | 2016 |
A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory | 2009 |
Antibiotic prophylaxis in third molar surgery: A randomized double-blind placebo-controlled clinical trial using split-mouth technique.
Topics: Acetaminophen; Adult; Amoxicillin; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Bacterial Agen | 2010 |
Comparison of oral versus sublingual piroxicam during postoperative pain management after lower third molar extraction.
Topics: Acetaminophen; Administration, Oral; Administration, Sublingual; Analgesics, Non-Narcotic; Anti-Infl | 2011 |
Efficacy of paracetamol versus diclofenac for Grade II ankle sprains.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Ankle Injuries; Anti-Inflammatory Agents | 2011 |
Evaluation of the muscle relaxant cyclobenzaprine after third-molar extraction.
Topics: Acetaminophen; Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Double-Blind Method; Edem | 2011 |
Effect of single dose preoperative intramuscular dexamethasone injection on lower impacted third molar surgery.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents; Dexamethasone; Double-Blind Method; Edem | 2012 |
Comparative study of tramadol combined with dexamethasone and diclofenac sodium in third-molar surgery.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2012 |
A randomized, double-blind crossover trial of paracetamol 1000 mg four times daily vs ibuprofen 600 mg: effect on swelling and other postoperative events after third molar surgery.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies | 2003 |
Naproxen 500 mg bid versus acetaminophen 1000 mg qid: effect on swelling and other acute postoperative events after bilateral third molar surgery.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Confidence | 2003 |
Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Cross-Over Stu | 2003 |
Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Cross-Over Stu | 2003 |
Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Cross-Over Stu | 2003 |
Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Cross-Over Stu | 2003 |
Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Cross-Over Stu | 2003 |
Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Cross-Over Stu | 2003 |
Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Cross-Over Stu | 2003 |
Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Cross-Over Stu | 2003 |
Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Cross-Over Stu | 2003 |
Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Ankle Injuries; Arthralgia; Contusions; Double-Blind Method | 2006 |
Effect of submucosal injection of dexamethasone on postoperative discomfort after third molar surgery: a prospective study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anesthesia, Local; Anti-Inflammatory Agents; Dexamet | 2007 |
Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over | 2008 |
Analgesic and anti-inflammatory effects of paracetamol evaluated by bilateral oral surgery.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents; Body Temperature; Clinical Trials as Top | 1980 |
Acute postoperative swelling after hand surgery: an exploratory, double-blind, randomised study with paracetamol, naproxen, and placebo.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N | 2001 |
Effect of apical trephination on postoperative pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Anti-Infla | 2001 |
Effect of prophylactic amoxicillin on endodontic flare-up in asymptomatic, necrotic teeth.
Topics: Acetaminophen; Adult; Amoxicillin; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Varianc | 2001 |
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla | 2001 |
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla | 2001 |
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla | 2001 |
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla | 2001 |
Pulsed electromagnetic energy therapy in third molar surgery.
Topics: Acetaminophen; Adolescent; Adult; Double-Blind Method; Edema; Electromagnetic Phenomena; Female; Hum | 1978 |
[Treatment of distortions and non-traumatic conditions of pain and swelling. Double-blind trial with an analgetic and detumescent drug combination].
Topics: Acetaminophen; Adult; Double-Blind Method; Drug Combinations; Drug Synergism; Edema; Humans; Joint D | 1978 |
Paracetamol/codeine in relieving pain following removal of impacted mandibular third molars.
Topics: Acetaminophen; Adolescent; Adult; Aspirin; Codeine; Drug Therapy, Combination; Edema; Female; Humans | 1975 |
Pain control after third molar surgery--a comparative study of ibuprofen (Ibumetin) and a paracetamol/codeine combination (Citodon).
Topics: Acetaminophen; Adolescent; Adult; Codeine; Drug Combinations; Edema; Female; Humans; Ibuprofen; Male | 1992 |
Evaluation of the anti-inflammatory effects of a low dose of acetaminophen following surgery in dogs.
Topics: Acetaminophen; Animals; Dogs; Edema; Evaluation Studies as Topic; Female; Forelimb; Male; Postoperat | 1991 |
The anti-oedematous efficacy of oxindanac equals that of paracetamol in acute postoperative inflammation; are weak cyclooxygenase inhibitors more effective than strong inhibitors?
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Double-Bli | 1989 |
Comparison of diflunisal and acetaminophen with codeine in the management of grade 2 ankle sprain.
Topics: Acetaminophen; Adult; Ankle Injuries; Codeine; Diflunisal; Drug Combinations; Edema; Female; Humans; | 1986 |
46 other studies available for acetaminophen and Anasarca
Article | Year |
---|---|
Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Design; Edema; Female; Male; Mic | 2009 |
Synthesis, biological evaluation and docking studies of novel benzopyranone congeners for their expected activity as anti-inflammatory, analgesic and antipyretic agents.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Catalytic D | 2009 |
Synthesis, pharmacological screening and in silico studies of new class of Diclofenac analogues as a promising anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Computer Simulation; Cyclooxygenase 1 | 2014 |
A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis.
Topics: Acetamides; Acetic Acid; Analgesics; Animals; Antipyretics; Chemical and Drug Induced Liver Injury; | 2020 |
Dual antioxidant structures with potent anti-inflammatory, hypolipidemic and cytoprotective properties.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Butanes; Carrageenan; Chemical and D | 2017 |
Delayed-type drug hypersensitivity caused by paracetamol in a 2-year-old boy, confirmed by a positive patch test reaction and oral provocation.
Topics: Acetaminophen; Antipyretics; Drug Eruptions; Edema; Face; Humans; Hypersensitivity, Delayed; Infant; | 2018 |
Salicytamide: a New Anti-inflammatory Designed Drug Candidate.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Edema; Mice; Nocicepti | 2018 |
LC-MS analyses of N-acetyl-p-benzoquinone imine-adducts of glutathione, cysteine, N-acetylcysteine, and albumin in a plasma sample: A case study from a patient with a rare acetaminophen-induced acute swelling rash.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Benzoquinones; Chemical and Drug Induced Liver | 2019 |
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty, | 2017 |
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty, | 2017 |
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty, | 2017 |
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty, | 2017 |
Management of the sodium hypochlorite accident: a rare but significant complication of root canal treatment.
Topics: Acetaminophen; Aged; Amoxicillin-Potassium Clavulanate Combination; Analgesics, Non-Narcotic; Anti-I | 2015 |
Comparison of the efficacy of low doses of methylprednisolone, acetaminophen, and dexketoprofen trometamol on the swelling developed after the removal of impacted third molar.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Edema; Humans; Ketoprofen; Methyl | 2015 |
Pathology in Practice. Acetaminophen (paracetamol) toxicosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anemia, Hemolytic; Animals; Behavior, Animal; Blood Cell Co | 2016 |
Delayed retrobulbar haemorrhage associated with a repeat sub-Tenon's block.
Topics: Acetaminophen; Acetazolamide; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Agents | 2008 |
Synthesis and biological activities of some novel triazoloquinazolines and triazinoquinazolines containing benzenesulfonamide moieties.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temp | 2010 |
Stellate ganglion blockade (SGB) for refractory index finger pain - a case report.
Topics: Abdominal Pain; Accidental Falls; Acetaminophen; Adult; Amines; Autonomic Nerve Block; Chronic Disea | 2011 |
Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Behavior, A | 2012 |
Effect of drainage upon access on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St | 2002 |
Postoperative complaints following impacted mandibular third molar surgery in Ile-Ife, Nigeria.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Edema; Female; Humans; Ibuprofen; Male; | 2002 |
The diagnosis of acetaminophen toxicosis in a cat.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cat Diseases; Cats; Edema; Fatal Outcome; Methemog | 2003 |
Gemcitabine-associated scleroderma-like changes of the lower extremities.
Topics: Acetaminophen; Amitriptyline; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy | 2004 |
A 32-year-old woman with breast swelling and crepitant rales.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Breast Diseases; Chest Pain; Diagnosis, Differential | 2004 |
Synthesis of new chemical entities from paracetamol and NSAIDs with improved pharmacodynamic profile.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroida | 2006 |
Paracetamol [acetaminophen]-induced gastrotoxicity: revealed by induced hyperacidity in combination with acute or chronic inflammation.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Animals; Arthritis, Ex | 2006 |
Suprofen, a new peripheral analgesic.
Topics: Acetaminophen; Analgesics; Animals; Arachidonic Acids; Arthritis, Experimental; Biological Assay; Ca | 1980 |
The influence of three prostaglandin biosynthesis stimulators on carrageenin-induced edema of rat paw.
Topics: Acetaminophen; Animals; Butylated Hydroxytoluene; Carrageenan; Edema; Male; Malondialdehyde; Microso | 1980 |
Delayed hypersensitivity reaction to paracetamol (acetaminophen).
Topics: Acetaminophen; Child; Child, Preschool; Dermatitis, Allergic Contact; Drug Hypersensitivity; Edema; | 1996 |
Antinociceptive and anti-oedematogenic properties of astilbin, taxifolin and some related compounds.
Topics: Acetaminophen; Acetates; Analgesics; Analgesics, Non-Narcotic; Animals; Aspirin; Edema; Flavonoids; | 2000 |
Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity.
Topics: Acetaminophen; Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents; Carrageenan; Ede | 2000 |
Design, synthesis and biological testing of a novel series of anti-inflammatory drugs.
Topics: Abdomen; Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 2001 |
Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Edema; Indoles; | 2002 |
Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Edema; Indoles; | 2002 |
Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Edema; Indoles; | 2002 |
Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Edema; Indoles; | 2002 |
Letter to the editor: reduction of post-operative swelling by paracetamol. An alternative hypothesis.
Topics: Acetaminophen; Edema; Humans; Postoperative Complications; Tooth Extraction | 1979 |
Increase in body temperature during carrageenin-induced paw oedema in the rat. Effect of non-steroid anti-inflammatory substances and essential fatty acid deficiency.
Topics: Acetaminophen; Aging; Animals; Anti-Inflammatory Agents; Brain Chemistry; Carrageenan; Edema; Fatty | 1979 |
Pathophysiology of acetaminophen overdosage toxicity: implications for management.
Topics: Acetaminophen; Acetylcysteine; Animals; Dogs; Dose-Response Relationship, Drug; Edema; Female; Mice; | 1978 |
Acetaminophen toxicosis in the cat.
Topics: Acetaminophen; Administration, Oral; Anemia; Animals; Bilirubin; Blood Urea Nitrogen; Cat Diseases; | 1975 |
Melkersson Rosenthal syndrome: oligosymptomatic form.
Topics: Acetaminophen; Child; Edema; Facial Paralysis; Female; Humans; Melkersson-Rosenthal Syndrome; Motor | 1992 |
Effects of acetaminophen after bilateral oral surgery: double dose twice daily versus standard dose four times daily.
Topics: Acetaminophen; Adolescent; Adult; Analgesia; Drug Administration Schedule; Edema; Female; Humans; Ma | 1991 |
Effect of centrally administered prostaglandin D2 and some prostaglandin synthesis inhibitors on carrageenan-induced paw oedema in rats.
Topics: Acetaminophen; Animals; Carrageenan; Dose-Response Relationship, Drug; Edema; Female; Hydrocortisone | 1989 |
Mode of analgesic action of dipyrone: direct antagonism of inflammatory hyperalgesia.
Topics: Acetaminophen; Aminopyrine; Analgesics; Animals; Aspirin; Bucladesine; Carrageenan; Dinoprostone; Di | 1985 |
Effects of paracetamol and acetylsalicylic acid on the post-operative course after experimental orthopaedic surgery in dogs.
Topics: Acetaminophen; Animals; Aspirin; Dogs; Edema; Female; Forelimb; Inflammation; Male; Pain, Postoperat | 1988 |
Interrelation of complaints after removal of impacted mandibular third molars.
Topics: Acetaminophen; Adolescent; Adult; Consumer Behavior; Dexamethasone; Edema; Female; Humans; Male; Mol | 1985 |
Paracetamol poisoning in a cat.
Topics: Acetaminophen; Animals; Ataxia; Cat Diseases; Cats; Edema; Female; Head | 1985 |
Effects of anti-inflammatory drugs on prostaglandin biosynthesis.
Topics: Acetaminophen; Aldosterone; Animals; Anti-Inflammatory Agents; Aspirin; Azathioprine; Benzoates; Bio | 1972 |
The sequelae of accidentally injecting sodium hypochlorite beyond the root apex. Report of a case.
Topics: Acetaminophen; Adult; Brompheniramine; Dental Caries; Edema; Female; Humans; Iatrogenic Disease; Ora | 1974 |
[Pharmacologic studies on the anti-inflammatory effect of pentosan polysulfate (SP 54) in combination with other analgesic or antiphlogistic agents].
Topics: Acetaminophen; Acetates; Animals; Anti-Inflammatory Agents; Dexamethasone; Drug Combinations; Drug S | 1973 |
Probable paracetamol toxicity in a cat.
Topics: Acetaminophen; Animals; Cat Diseases; Cats; Chloramphenicol; Conjunctivitis; Edema; Kidney; Liver; L | 1974 |
[Enzyme-analgesic combination in dentistry].
Topics: Acetaminophen; Anti-Inflammatory Agents; Drug Synergism; Edema; Humans; Surgery, Oral; Trypsin | 1968 |