acetaminophen has been researched along with Anaphylaxis in 66 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Anaphylaxis: An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An acute anaphylactic reaction after a conventional antipyretic dose of ibuprofen was diagnosed in a child with allergic rhinitis, recurrent idiopathic urticaria, and nonimmunologic cross-reactive hypersensitivity to nonsteroidal antiinflammatory drugs and acetaminophen." | 7.74 | Severe anaphylactic reaction to ibuprofen in a child with recurrent urticaria. ( Chin, CW; Chong, NK; Hoon, LS; Hwee, CY; Kang, LW; Kidon, MI, 2007) |
| "We report an asthmatic adolescent female who had anaphylaxis with 650 mg acetaminophen after tolerating 325-mg doses for years." | 7.69 | Acetaminophen anaphylaxis with aspirin and sodium salicylate sensitivity: a case report. ( Ham Pong, A; Schwarz, N, 1996) |
| "To determine whether the different modes of action of aspirin and acetaminophen are associated with different incidences of bronchoconstriction, and whether there is cross-reactivity in terms of intolerance, selected asthmatics were challenged with both analgesics." | 7.66 | Acetaminophen and aspirin challenges in subgroups of asthmatics. ( Falliers, CJ, 1983) |
| "Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects." | 6.45 | Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. ( Kleijnen, J; Soares-Weiser, K; Southey, ER, 2009) |
| "Relevant articles in the medical literature were derived from searching the MEDLINE database with key terms aspirin-sensitive asthma, cyclo-oxygenase enzymes 1 and 2." | 4.81 | Sensitivity to nonsteroidal anti-inflammatory drugs. ( Namazy, JA; Simon, RA, 2002) |
| "We compared the incidence of adverse drug events of a two-bag IV acetylcysteine regimen with that of the traditional three-bag regimen." | 3.83 | Simplification of the standard three-bag intravenous acetylcysteine regimen for paracetamol poisoning results in a lower incidence of adverse drug reactions. ( Graudins, A; Wong, A, 2016) |
| "An acute anaphylactic reaction after a conventional antipyretic dose of ibuprofen was diagnosed in a child with allergic rhinitis, recurrent idiopathic urticaria, and nonimmunologic cross-reactive hypersensitivity to nonsteroidal antiinflammatory drugs and acetaminophen." | 3.74 | Severe anaphylactic reaction to ibuprofen in a child with recurrent urticaria. ( Chin, CW; Chong, NK; Hoon, LS; Hwee, CY; Kang, LW; Kidon, MI, 2007) |
| " Oral rechallenge resulted in generalized urticaria associated with an increased plasma level of histamine." | 3.71 | Acetaminophen (paracetamol)-induced anaphylactic shock. ( Bachmeyer, C; Blay, F; Habki, R; Leynadier, F; Vermeulen, C, 2002) |
| "Post-anesthesia anaphylactic reactions or those seen during drug provocation tests with a systemic clinical reaction may be confirmed by the sequential release into blood of plasma histamine, tryptase and leukotriene C4 and into urine of urinary methylhistamine and leukotriene E4." | 3.70 | [Importance of the urinary leukotriene E4 level. Preliminary study]. ( Drouet, M; el Founini, M; Sabbah, A, 1998) |
| "A 32-year-old patient developed an anaphylactic reaction minutes after oral intake of acetaminophen-containing tablets (Doregrippin))." | 3.70 | Anaphylaxis to polyvinylpyrrolidone in an analgesic preparation. ( Gleichmann, E; Grewe, M; Krutmann, J; Rönnau, AC; Ruzicka, T; Unver, E; Wulferink, M, 2000) |
| "We report an asthmatic adolescent female who had anaphylaxis with 650 mg acetaminophen after tolerating 325-mg doses for years." | 3.69 | Acetaminophen anaphylaxis with aspirin and sodium salicylate sensitivity: a case report. ( Ham Pong, A; Schwarz, N, 1996) |
| "We describe four cases of anaphylaxis to paracetamol without co-existing aspirin intolerance and review the Australian experience in paracetamol anaphylaxis." | 3.68 | Paracetamol anaphylaxis. ( Czarny, D; Leung, R; Plomley, R, 1992) |
| "To determine whether the different modes of action of aspirin and acetaminophen are associated with different incidences of bronchoconstriction, and whether there is cross-reactivity in terms of intolerance, selected asthmatics were challenged with both analgesics." | 3.66 | Acetaminophen and aspirin challenges in subgroups of asthmatics. ( Falliers, CJ, 1983) |
| "There were 362 patients, and anaphylactoid reactions occurred in 14." | 2.73 | Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose. ( Dow, MA; Pettie, JM; Robinson, OD; Stephen, AF; Waring, WS, 2008) |
| " Some authors do not recommend treatment with N-acetylcysteine at low paracetamol plasma concentrations since unnecessary adverse effects may be induced." | 2.50 | Recommendations for the paracetamol treatment nomogram and side effects of N-acetylcysteine. ( de Vries, I; Koppen, A; Meulenbelt, J; van Riel, A, 2014) |
| "Most anaphylactoid reactions occur at the start of acetylcysteine treatment when concentrations are highest." | 2.45 | Adverse reactions associated with acetylcysteine. ( Bateman, DN; Sandilands, EA, 2009) |
| "Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects." | 2.45 | Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. ( Kleijnen, J; Soares-Weiser, K; Southey, ER, 2009) |
| " Dosing errors and hyponatremia have occurred in pediatric patients receiving i." | 2.43 | Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning. ( Kanter, MZ, 2006) |
| "Non-life-threatening anaphylactoid reactions to intravenous NAC are treated easily and the infusion may be continued or restarted safely after the administration of diphenhydramine." | 2.40 | Management of anaphylactoid reactions to intravenous N-acetylcysteine. ( Bailey, B; McGuigan, MA, 1998) |
| "Anaphylaxis is a life-threatening medical emergency." | 1.91 | Anaphylaxis following a pleural puncture bringing back a rock water-like liquid. ( Abdenadher, M; Ben Mansour, A; Ben Saad, S; Daghfous, H; Neji, H; Slim, A; Tritar, F, 2023) |
| "Anaphylactoid reactions are well-documented adverse events associated with the intravenous administration of N-acetylcysteine (NAC) in patients with acetaminophen overdose." | 1.62 | A Case Report of a Severe, Unusually Delayed Anaphylactoid Reaction to Intravenous N-Acetylcysteine During Treatment of Acute Acetaminophen Toxicity in an Adolescent. ( Cao, DJ; Epperson, LC; Weiss, ST, 2021) |
| "Fewer anaphylactoid reactions (itch, rash, and swelling) occurred using the two-bag regimen (14% versus 5%, p = ." | 1.48 | Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose. ( Chandru, P; Gunja, N; Lim, JME; McNulty, R, 2018) |
| "An anaphylactoid reaction was documented in 528 (8." | 1.48 | Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning. ( Bailey, B; Chopra, P; Gosselin, S; Johnson, D; Nettel-Aguirre, A; Purssell, R; Rumack, B; Sivilotti, MLA; Spyker, D; Thompson, M; Victorino, C; Yarema, M, 2018) |
| "22." | 1.42 | Epidemiology, management and outcome of paracetamol poisoning in an inner city emergency department. ( Benger, J; Bramley, K; Carroll, R; Griffin, L; Gunnell, D; Potokar, J; Williams, S, 2015) |
| " Together with these new biomarkers of hepatotoxicity, a 12-hour acetylcysteine protocol offers clinicians and patients the possibility for better targeting of therapy, fewer adverse effects, a simpler dosing regimen, and shorter hospital stay." | 1.42 | Changing the Management of Paracetamol Poisoning. ( Bateman, DN, 2015) |
| "Ibuprofen was the most frequent cause of reactions (35%), however, diclofenac was the most frequent cause of anaphylaxis (48%)." | 1.38 | Oral drug challenges in non-steroidal anti-inflammatory drug-induced urticaria, angioedema and anaphylaxis. ( Chaudhry, T; Heddle, R; Hissaria, P; Kette, F; Smith, WB; Wiese, M, 2012) |
| "9%)." | 1.36 | A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose. ( Aguilera, E; Al-Helial, M; Arnold, T; Bebarta, VS; Bogdan, G; Buchanan, J; Clark, RF; Dart, R; Delgado, J; Froberg, B; Haur, W; Heard, K; Hoppe, J; Kao, L; Kokko, J; Lares, C; Lavonas, E; McDonagh, J; Mendoza, C; Mlynarchek, S; O'Malley, G; Odujebe, O; Qi, M; Rhyee, S; Stanford, C; Tan, HH; Tran, NN; Varney, S; Zosel, A, 2010) |
| "We conduct a study to determine the rate of adverse events (anaphylactoid and cardiorespiratory) associated with the use of oral N-acetylcysteine by the intravenous route for the treatment of suspected acetaminophen poisoning and to examine specific variables that may be associated with adverse events." | 1.32 | What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning? ( Brizendine, EJ; Furbee, RB; Kao, LW; Kirk, MA; Mehta, NH; Skinner, JR, 2003) |
| "A 58-year old woman had anaphylactic reaction two hours after oral administration of paracetamol." | 1.32 | Anaphylactic reaction due to paracetamol. ( Balachandran, C; Gowrinath, K, 2004) |
| "A case of an anaphylactoid reaction to paracetamol is described." | 1.31 | Anaphylactoid reactions to paracetamol. ( Ayonrinde, OT; Saker, BM, 2000) |
| "This case illustrates a variant anaphylactoid reaction to intravenously administered acetylcysteine and emphasizes the need for practitioners to consider the potential for these reactions prior to initiation of therapy and indicates appropriate treatment of these reactions." | 1.28 | Anaphylactoid reaction to intravenous acetylcysteine associated with electrocardiographic abnormalities. ( Bonfiglio, MF; Hulisz, DT; Martin, BR; Traeger, SM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (7.58) | 18.7374 |
| 1990's | 14 (21.21) | 18.2507 |
| 2000's | 25 (37.88) | 29.6817 |
| 2010's | 18 (27.27) | 24.3611 |
| 2020's | 4 (6.06) | 2.80 |
| Authors | Studies |
|---|---|
| Humphries, C | 1 |
| Roberts, G | 1 |
| Taheem, A | 1 |
| Abdel Kader, H | 1 |
| Kidd, R | 1 |
| Smith, J | 1 |
| Ben Saad, S | 1 |
| Ben Mansour, A | 1 |
| Slim, A | 1 |
| Neji, H | 1 |
| Abdenadher, M | 1 |
| Daghfous, H | 1 |
| Tritar, F | 1 |
| Epperson, LC | 1 |
| Weiss, ST | 1 |
| Cao, DJ | 1 |
| Preuss, JF | 1 |
| Goddard, CE | 1 |
| Clarke, RC | 1 |
| Platt, PR | 1 |
| Sadleir, PH | 1 |
| McNulty, R | 1 |
| Lim, JME | 1 |
| Chandru, P | 1 |
| Gunja, N | 1 |
| Yarema, M | 1 |
| Chopra, P | 1 |
| Sivilotti, MLA | 1 |
| Johnson, D | 1 |
| Nettel-Aguirre, A | 1 |
| Bailey, B | 2 |
| Victorino, C | 1 |
| Gosselin, S | 1 |
| Purssell, R | 1 |
| Thompson, M | 1 |
| Spyker, D | 1 |
| Rumack, B | 1 |
| Rodríguez-Fernández, A | 1 |
| Sánchez-Domínguez, M | 1 |
| Noguerado-Mellado, B | 1 |
| Rojas-Pérez-Ezquerra, P | 1 |
| Schmidt, LE | 1 |
| Coulson, JM | 1 |
| Thompson, JP | 1 |
| Yamamoto, T | 1 |
| Spencer, T | 1 |
| Dargan, PI | 3 |
| Wood, DM | 1 |
| Carroll, R | 1 |
| Benger, J | 1 |
| Bramley, K | 1 |
| Williams, S | 1 |
| Griffin, L | 1 |
| Potokar, J | 1 |
| Gunnell, D | 1 |
| Koppen, A | 1 |
| van Riel, A | 1 |
| de Vries, I | 1 |
| Meulenbelt, J | 1 |
| Bateman, DN | 3 |
| Wong, A | 1 |
| Graudins, A | 2 |
| Jain, SS | 1 |
| Green, S | 1 |
| Rose, M | 1 |
| Dass, K | 1 |
| Bose, S | 1 |
| Ditto, AM | 1 |
| Numata, T | 1 |
| Fukushi, R | 1 |
| Ito, T | 1 |
| Tsuboi, R | 1 |
| Harada, K | 1 |
| Tan, CJ | 1 |
| Sklar, GE | 1 |
| Waring, WS | 2 |
| Stephen, AF | 1 |
| Robinson, OD | 1 |
| Dow, MA | 1 |
| Pettie, JM | 1 |
| Pakravan, N | 1 |
| Sharma, S | 1 |
| Ludlam, C | 1 |
| Megson, I | 1 |
| Goldberg, JB | 1 |
| Ho, MH | 1 |
| Tung, JY | 1 |
| Lee, TL | 1 |
| Tsoi, NS | 1 |
| Lau, YL | 1 |
| Konrad, FM | 1 |
| Schroeder, TH | 1 |
| Sandilands, EA | 1 |
| Southey, ER | 1 |
| Soares-Weiser, K | 1 |
| Kleijnen, J | 1 |
| Bebarta, VS | 1 |
| Kao, L | 1 |
| Froberg, B | 1 |
| Clark, RF | 1 |
| Lavonas, E | 1 |
| Qi, M | 1 |
| Delgado, J | 1 |
| McDonagh, J | 1 |
| Arnold, T | 1 |
| Odujebe, O | 1 |
| O'Malley, G | 1 |
| Lares, C | 1 |
| Aguilera, E | 1 |
| Dart, R | 1 |
| Heard, K | 1 |
| Stanford, C | 1 |
| Kokko, J | 1 |
| Bogdan, G | 1 |
| Mendoza, C | 1 |
| Mlynarchek, S | 1 |
| Rhyee, S | 1 |
| Hoppe, J | 1 |
| Haur, W | 1 |
| Tan, HH | 1 |
| Tran, NN | 1 |
| Varney, S | 1 |
| Zosel, A | 1 |
| Buchanan, J | 1 |
| Al-Helial, M | 1 |
| Zyoud, SH | 1 |
| Awang, R | 1 |
| Sulaiman, SA | 1 |
| Al-Jabi, SW | 1 |
| Chaudhry, T | 1 |
| Hissaria, P | 1 |
| Wiese, M | 1 |
| Heddle, R | 1 |
| Kette, F | 1 |
| Smith, WB | 1 |
| Couto, M | 1 |
| Gaspar, A | 1 |
| Morais-Almeida, M | 1 |
| Bachmeyer, C | 1 |
| Vermeulen, C | 1 |
| Habki, R | 1 |
| Blay, F | 1 |
| Leynadier, F | 1 |
| Appelboam, AV | 1 |
| Knighton, J | 1 |
| Namazy, JA | 1 |
| Simon, RA | 1 |
| Kao, LW | 1 |
| Kirk, MA | 1 |
| Furbee, RB | 1 |
| Mehta, NH | 1 |
| Skinner, JR | 1 |
| Brizendine, EJ | 1 |
| Lynch, RM | 1 |
| Robertson, R | 1 |
| Gowrinath, K | 1 |
| Balachandran, C | 1 |
| Kerr, F | 1 |
| Dawson, A | 1 |
| Whyte, IM | 1 |
| Buckley, N | 1 |
| Murray, L | 1 |
| Chan, B | 1 |
| Trudinger, B | 1 |
| Horowitz, BZ | 1 |
| Hendrickson, RG | 1 |
| Pizarro-Osilla, C | 1 |
| Manini, AF | 1 |
| Snider, C | 1 |
| Gawarammana, IB | 1 |
| Greene, SL | 1 |
| Jones, AL | 1 |
| Kanter, MZ | 1 |
| Pizon, AF | 1 |
| Lovecchio, F | 1 |
| Bergendorff, O | 1 |
| Hansson, C | 1 |
| Kang, LW | 1 |
| Kidon, MI | 1 |
| Chin, CW | 1 |
| Hoon, LS | 1 |
| Hwee, CY | 1 |
| Chong, NK | 1 |
| Vale, JA | 1 |
| Wheeler, DC | 1 |
| Falliers, CJ | 1 |
| Ell, C | 1 |
| Domschke, S | 1 |
| Domschke, W | 1 |
| Martin, JA | 1 |
| Lazaro, M | 1 |
| Cuevas, M | 1 |
| Alvarez-Cuesta, E | 1 |
| Doan, T | 1 |
| Greenberger, PA | 1 |
| Schwarz, N | 1 |
| Ham Pong, A | 1 |
| Sabbah, A | 2 |
| Sainte-Laudy, J | 1 |
| Drouet, M | 2 |
| Lauret, MG | 1 |
| Loiry, M | 1 |
| Stavem, K | 1 |
| McGuigan, MA | 1 |
| el Founini, M | 1 |
| Kumar, RK | 1 |
| Byard, I | 1 |
| Spitz, E | 1 |
| Testud, F | 1 |
| Ben Ayed, H | 1 |
| Vial, T | 1 |
| Descotes, J | 1 |
| Stephenson, I | 1 |
| Nightingale, JM | 1 |
| Ayonrinde, OT | 1 |
| Saker, BM | 1 |
| Rönnau, AC | 1 |
| Wulferink, M | 1 |
| Gleichmann, E | 1 |
| Unver, E | 1 |
| Ruzicka, T | 1 |
| Krutmann, J | 1 |
| Grewe, M | 1 |
| Recasens, M | 1 |
| Nogué, S | 1 |
| Gómez, E | 1 |
| Walton, NG | 1 |
| Mann, TA | 1 |
| Shaw, KM | 1 |
| Leung, R | 1 |
| Plomley, R | 1 |
| Czarny, D | 1 |
| Bonfiglio, MF | 1 |
| Traeger, SM | 1 |
| Hulisz, DT | 1 |
| Martin, BR | 1 |
| Mullins, RJ | 1 |
| Russell, A | 1 |
| McGrath, GJ | 1 |
| Smith, R | 1 |
| Sutherland, DC | 1 |
| Van Diem, L | 1 |
| Grilliat, JP | 1 |
| Pastorello, E | 1 |
| Qualizza, RM | 1 |
| Luraghi, MT | 1 |
| Ispano, M | 1 |
| Villa, AM | 1 |
| Ortolani, C | 1 |
| Zanussi, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Placebo Controlled Trial of Intravenous N-Acetylcysteine for the Treatment of Acute Ischemic Stroke[NCT04918719] | Phase 2 | 118 participants (Anticipated) | Interventional | 2021-06-01 | Not yet recruiting | ||
| N-Acetylcysteine to Prevent Radiocontrast Nephropathy in Emergency Department Patients[NCT00780962] | Phase 2 | 399 participants (Actual) | Interventional | 2007-10-16 | Completed | ||
| A Phase 2 Trial of N-Acetylcysteine in Biliary Atresia After Kasai Portoenterostomy[NCT03499249] | Phase 2 | 16 participants (Anticipated) | Interventional | 2018-05-18 | Active, not recruiting | ||
| A Pilot Trial to Determine the Effective Dose of N-acetylcysteine for Opioid Reduction in Patients Undergoing Spine Surgery.[NCT04562597] | Phase 1/Phase 2 | 50 participants (Actual) | Interventional | 2021-01-20 | Completed | ||
| Treatment of Acetaminophen Toxicity With Intravenous vs Oral N-acetylcysteine: A Retrospective Review[NCT00725179] | 130 participants (Anticipated) | Observational | 2008-08-31 | Completed | |||
| Treatment of Acetaminophen Toxicity With Intravenous vs. Oral N-acetylcysteine: A Retrospective Review[NCT01465542] | 47 participants (Actual) | Observational | 2011-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Contrast-induced nephropathy was defined as an increase in serum creatinine level of greater than or equal to 0.5 mg/dL or an increase of 25% above baseline. The primary outcome was measured by the change in serum creatinine level from the pre-radiocontrast baseline to the serum creatinine level measured 48 to 72 hours after radiocontrast administration. (NCT00780962)
Timeframe: 48-72 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| N-Acetycysteine Group | 14 |
| 0.9% Sodium-chloride Group | 12 |
Post operative opioid consumption in the 12 hours that occur post-operatively. (NCT04562597)
Timeframe: 12 hours
| Intervention | IV morphine mg equivalents (Mean) |
|---|---|
| Placebo | 19.4 |
| N-acetylcysteine (NAC) | 15.6 |
Post operative opioid consumption ry 6 hours post operative. Data are reported as mean (95% CI) or mean difference (95% CI) estimated from a linear mixed model of opioid consumption over time including main effects for treatment group, postoperative time, and the interaction between treatment group and postoperative time and a random subject effect. (NCT04562597)
Timeframe: 6-48 hours
| Intervention | IV morphine mg equivalents (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| 6 hours | 18 hours | 24 hours | 30 hours | 36 hours | 42 | 48 | |
| N-acetylcysteine (NAC) | 12.0 | 19.9 | 24.7 | 27.2 | 29.7 | 33.1 | 34.9 |
| Placebo | 14.6 | 25.0 | 29.6 | 34.0 | 37.9 | 40.9 | 43.3 |
10 reviews available for acetaminophen and Anaphylaxis
| Article | Year |
|---|---|
Anaphylaxis to intravenous paracetamol containing povidone. A case report and narrative review of excipient allergy related to anaesthesia.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anaphylaxis; Australia; Excipients; Humans; Povidone; Skin | 2020 |
Recommendations for the paracetamol treatment nomogram and side effects of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Free Radical Scavengers; Hospi | 2014 |
Acetaminophen anaphylaxis diagnosed by skin prick test.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anaphylaxis; Drug Hypersensitivity; Female; Humans; Skin Te | 2016 |
Adverse reactions associated with acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Anaphylaxis; Antidote | 2009 |
Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever.
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Anaphylaxis; Child; Fever; Gastrointestinal Hem | 2009 |
Selective anaphylaxis to paracetamol in a child.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anaphylaxis; Drug Hypersensitivity; Humans; Imm | 2012 |
Sensitivity to nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Adult; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Bleedin | 2002 |
Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anaphylaxis; A | 2006 |
Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anaphylaxis; A | 2006 |
Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anaphylaxis; A | 2006 |
Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anaphylaxis; A | 2006 |
Management of anaphylactoid reactions to intravenous N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Anti-Allergic Agents; Diphenhydramine; Free Radical Scav | 1998 |
Commentary-anaphylactic reactions to paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anaphylaxis; Dose-Response Relationship, Drug; Humans | 2000 |
3 trials available for acetaminophen and Anaphylaxis
| Article | Year |
|---|---|
Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Drug Interac | 2008 |
The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Anaphylaxis; Aspartate Aminotransferases | 2005 |
Breastfeeding anaphylaxis.
Topics: Acetaminophen; Adult; Anaphylaxis; Aspirin; Breast Feeding; Humans; Infant, Newborn; Lactation | 1991 |
53 other studies available for acetaminophen and Anaphylaxis
| Article | Year |
|---|---|
SNAPTIMED study: does the Scottish and Newcastle Antiemetic Protocol achieve timely intervention and management from the emergency department to discharge for paracetamol poisoning?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Antiemetics; Drug Overdose; Em | 2023 |
Anaphylaxis following a pleural puncture bringing back a rock water-like liquid.
Topics: Acetaminophen; Adolescent; Anaphylaxis; Drug Hypersensitivity; Female; Humans; Pleura; Punctures | 2023 |
A Case Report of a Severe, Unusually Delayed Anaphylactoid Reaction to Intravenous N-Acetylcysteine During Treatment of Acute Acetaminophen Toxicity in an Adolescent.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anaphy | 2021 |
Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Chemical and Drug Induced Liver Injury; Drug Over | 2018 |
Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anaphylaxis; Antid | 2018 |
Flare-Up Phenomenon of Intradermal Test with Anaphylactic Reaction to Paracetamol (Acetaminophen).
Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Aged, 80 and over; Allergens; Anap | 2019 |
Identification of patients at risk of anaphylactoid reactions to N-acetylcysteine in the treatment of paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Drug Hyperse | 2013 |
Anaphylactoid reactions to N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Drug Hypersensitivi | 2013 |
Incidence and management of N-acetylcysteine-related anaphylactoid reactions during the management of acute paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Drug Overdose; Female; | 2014 |
Epidemiology, management and outcome of paracetamol poisoning in an inner city emergency department.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anaphylaxis | 2015 |
Changing the Management of Paracetamol Poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Antiemetics; Biomar | 2015 |
Simplification of the standard three-bag intravenous acetylcysteine regimen for paracetamol poisoning results in a lower incidence of adverse drug reactions.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Anaphylaxis; Drug Ove | 2016 |
Anaphylaxis following intravenous paracetamol: the problem is the solution.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anaphylaxis; Drug Hypersensitivity; Female; Hu | 2015 |
An unusual case of immediate hypersensitivity reaction to a common medication.
Topics: Acetaminophen; Administration, Oral; Adult; Anaphylaxis; Desensitization, Immunologic; Drug Hypersen | 2016 |
Characterisation and outcomes of adult patients with paracetamol overdose presenting to a tertiary hospital in Singapore.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Anaphylaxis; Drug Overdose; Female; Humans; | 2017 |
Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Blood Coagul | 2008 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Epinephrine; Fr | 2008 |
Anaphylaxis to paracetamol.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anaphylaxis; Humans; Male | 2008 |
Anaesthesia in patients with mastocytosis.
Topics: Acetaminophen; Anaphylaxis; Androstanols; Anesthesia, General; Anti-Inflammatory Agents, Non-Steroid | 2009 |
A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Drug Administration Routes; Drug Overdose; Humans; Infus | 2010 |
Effects of delay in infusion of N-acetylcysteine on appearance of adverse drug reactions after acetaminophen overdose: a retrospective study.
Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Antidotes; Drug Overdose; Female; Humans; Male; R | 2010 |
Oral drug challenges in non-steroidal anti-inflammatory drug-induced urticaria, angioedema and anaphylaxis.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anaphylaxis; Angioedema; Anti-Inflammatory Agents, Non-Stero | 2012 |
Acetaminophen (paracetamol)-induced anaphylactic shock.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Epinephrine; Female; Histamine; Humans; | 2002 |
Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients with asthma.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Asthma; Fata | 2002 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana | 2003 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana | 2003 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana | 2003 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana | 2003 |
Anaphylactoid reactions to intravenous N-acetylcysteine: a prospective case controlled study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Anaphylaxis; Antidotes; Case-Control Stud | 2004 |
Anaphylactic reaction due to paracetamol.
Topics: Acetaminophen; Adrenergic Agonists; Analgesics, Non-Narcotic; Anaphylaxis; Epinephrine; Female; Huma | 2004 |
Not so fast!
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Dose-Response Relationship, Drug; Drug Administration Sc | 2006 |
Intravenous loading infusion rates of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Drug Administration Schedule; Drug Evaluation; Emergency | 2006 |
Australian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Dose-Response Relationship, Drug; Drug Administration Sc | 2006 |
Adverse reaction from use of intravenous N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Anaphylaxis; Chemical and Drug Induced Liver Injury; Drug | 2006 |
Urticaria and anaphylaxis to povidone in a paracetamol preparation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anaphylaxis; Child; Drug Eruptions; Humans; Male; Pharmaceu | 2007 |
Severe anaphylactic reaction to ibuprofen in a child with recurrent urticaria.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Child | 2007 |
Anaphylactoid reaction to acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Drug Hypersensitivity; Female; Humans; Middle Aged | 1982 |
Acetaminophen and aspirin challenges in subgroups of asthmatics.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anaphylaxis; Aspirin; Asthma; Bronchial Provocation Tests; D | 1983 |
[Benefit-risk considerations in metamizole treatment. Rational recommendations for indications and contra-indications according to current knowledge].
Topics: Acetaminophen; Agranulocytosis; Aminopyrine; Anaphylaxis; Aspirin; Dipyrone; Humans; Injections, Int | 1982 |
Paracetamol anaphylaxis.
Topics: Acetaminophen; Anaphylaxis; Diagnosis, Differential; Humans | 1993 |
Nearly fatal episodes of hypotension, flushing, and dyspnea in a 47-year-old woman.
Topics: Acetaminophen; Anaphylaxis; Diagnosis, Differential; Drug Hypersensitivity; Dyspnea; Female; Flushin | 1993 |
Acetaminophen anaphylaxis with aspirin and sodium salicylate sensitivity: a case report.
Topics: Acetaminophen; Adolescent; Anaphylaxis; Aspirin; Cross Reactions; Drug Hypersensitivity; Female; Hum | 1996 |
[Anaphylactic or anaphylactoid reactions to paracetamol. Report of 3 cases].
Topics: Acetaminophen; Adult; Anaphylaxis; Basophil Degranulation Test; CD4-Positive T-Lymphocytes; Drug Eru | 1997 |
[Anaphylactic reaction to N-acetylcysteine after poisoning with paracetamol].
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Drug Overdos | 1997 |
[Importance of the urinary leukotriene E4 level. Preliminary study].
Topics: Acetaminophen; Anaphylaxis; Anesthetics; Aspirin; Biomarkers; Chymases; Drug Hypersensitivity; Hista | 1998 |
Paracetamol as a cause of anaphylaxis.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anaphylaxis; Female; Humans | 1999 |
Possible mechanism of paracetamol anaphylaxis.
Topics: Acetaminophen; Adult; Anaphylaxis; Humans; Male | 1999 |
[No N-acetylcysteine in the absence of verified paracetamol intoxication].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Chemical and Drug I | 1999 |
Anaphylactoid reactions to paracetamol.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anaphylaxis; Drug Hypersensitivity; Female; Humans; R | 2000 |
Anaphylaxis to polyvinylpyrrolidone in an analgesic preparation.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Humans; Immunoglobulin E; Male; Pharmac | 2000 |
[Anaphylactoid reaction in relation to the use of N-acetylcysteine the prevention of paracetamol hepatotoxicity].
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Chemical and | 2001 |
Anaphylactoid reaction to N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Drug Hypersensitivity; Female; Humans | 1979 |
Paracetamol anaphylaxis.
Topics: Acetaminophen; Anaphylaxis; Angioedema; Aspirin; Bronchial Spasm; Cross Reactions; Humans; Hypotensi | 1992 |
Anaphylactoid reaction to intravenous acetylcysteine associated with electrocardiographic abnormalities.
Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Drug Overdose; Electrocardiography; Female; Human | 1992 |
Anaphylactic shock induced by paracetamol.
Topics: Acetaminophen; Anaphylaxis; Drug Hypersensitivity; Female; Humans; Middle Aged | 1990 |
[Occurrence of drug reactions].
Topics: Acetaminophen; Adult; Anaphylaxis; Angioedema; Aspirin; Asthma; Drug Hypersensitivity; Emergencies; | 1986 |