acetaminophen has been researched along with Alloxan Diabetes in 25 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Evidence from epidemiological, in vitro and animal studies has accumulated to support the idea that aspirin, ibuprofen and paracetamol protect against cataract." | 7.68 | Prevention of cataract in diabetic rats by aspirin, paracetamol (acetaminophen) and ibuprofen. ( Blakytny, R; Harding, JJ, 1992) |
| "Evidence from epidemiological, in vitro and animal studies has accumulated to support the idea that aspirin, ibuprofen and paracetamol protect against cataract." | 3.68 | Prevention of cataract in diabetic rats by aspirin, paracetamol (acetaminophen) and ibuprofen. ( Blakytny, R; Harding, JJ, 1992) |
| " In C57BL/6J mice, streptozotocin caused a dosage dependent increase in fasting blood glucose (FBG), from 100 to >600mg/dl." | 1.35 | Acetaminophen normalizes glucose homeostasis in mouse models for diabetes. ( Clegg, DJ; D'Alessio, DA; Genter, MB; Kendig, EL; Schneider, SN; Shertzer, HG, 2008) |
| " Both steady-state volume of distribution and elimination half-life of acetaminophen were decreased in diabetic rats by 23 and 25%, respectively." | 1.28 | Long-term diabetes alters the hepatobiliary clearance of acetaminophen, bilirubin and digoxin. ( Sherman, SE; Watkins, JB, 1992) |
| " The rate of formation of acetaminophen sulfate was also modestly increased in diabetic animals, whereas the apparent rate of the toxic pathway was approximately equal in both normal and diabetic animals." | 1.26 | Increased resistance of diabetic rats to acetaminophen-induced hepatotoxicity. ( Jollow, DJ; Price, VF, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (32.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 3 (12.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maikawa, CL | 1 |
| Chen, PC | 1 |
| Vuong, ET | 1 |
| Nguyen, LT | 1 |
| Mann, JL | 1 |
| d'Aquino, AI | 1 |
| Lal, RA | 1 |
| Maahs, DM | 1 |
| Buckingham, BA | 1 |
| Appel, EA | 1 |
| Wang, Z | 2 |
| Li, QQ | 2 |
| Huang, CK | 2 |
| Dong, YY | 2 |
| Lang, LP | 2 |
| Sun, W | 2 |
| Qian, JC | 2 |
| Zhang, XD | 2 |
| Reza, MS | 1 |
| Shuvo, MSR | 1 |
| Hassan, MM | 1 |
| Basher, MA | 1 |
| Islam, MA | 1 |
| Naznin, NE | 1 |
| Jafrin, S | 1 |
| Ahmed, KS | 1 |
| Hossain, H | 1 |
| Daula, AFMSU | 1 |
| Wu, Y | 1 |
| Huang, X | 1 |
| Yang, M | 1 |
| Xu, J | 1 |
| Chen, Z | 1 |
| Yu, Z | 1 |
| Liu, J | 2 |
| Sathya, A | 1 |
| Siddhuraju, P | 1 |
| Déciga-Campos, M | 1 |
| Ortíz-Andrade, R | 1 |
| Gong, YH | 1 |
| Yu, XR | 1 |
| Liu, HL | 1 |
| Yang, N | 1 |
| Zuo, PP | 1 |
| Huang, YG | 1 |
| Bienert, A | 1 |
| Kamińska, A | 1 |
| Olszewski, J | 1 |
| Gracz, J | 1 |
| Grabowski, T | 1 |
| Wolc, A | 1 |
| Grześkowiak, E | 1 |
| Shankar, K | 2 |
| Vaidya, VS | 2 |
| Apte, UM | 1 |
| Manautou, JE | 1 |
| Ronis, MJ | 1 |
| Bucci, TJ | 2 |
| Mehendale, HM | 3 |
| Corton, JC | 1 |
| Waalkes, MP | 1 |
| Oya, M | 1 |
| Hosokawa, M | 1 |
| Tsukada, H | 1 |
| Fukuda, K | 1 |
| Nakamura, H | 1 |
| Tsukiyama, K | 1 |
| Nagashima, K | 1 |
| Fujimoto, S | 1 |
| Yamada, Y | 1 |
| Seino, Y | 1 |
| Sawant, SP | 1 |
| Dnyanmote, AV | 1 |
| Mitra, MS | 1 |
| Chilakapati, J | 1 |
| Warbritton, A | 1 |
| Latendresse, JR | 1 |
| Shertzer, HG | 1 |
| Schneider, SN | 1 |
| Kendig, EL | 1 |
| Clegg, DJ | 1 |
| D'Alessio, DA | 1 |
| Genter, MB | 1 |
| Price, VF | 3 |
| Jollow, DJ | 4 |
| Roberts, S | 1 |
| Price, V | 1 |
| Smith, C | 1 |
| Takeda, M | 1 |
| Mizutani, Y | 1 |
| Yamano, M | 1 |
| Tsukamoto, K | 1 |
| Suzuki, T | 1 |
| Hassing, JM | 1 |
| Rosenberg, H | 1 |
| Stohs, SJ | 1 |
| Watkins, JB | 1 |
| Sherman, SE | 1 |
| Blakytny, R | 1 |
| Harding, JJ | 1 |
| Jeffery, EH | 1 |
| Arndt, K | 1 |
| Haschek, WM | 1 |
| Koizumi, F | 1 |
| Kawamura, T | 1 |
| Ishimori, A | 1 |
| Siegers, CP | 1 |
| Loeser, W | 1 |
| Younes, M | 1 |
| Yue, DK | 1 |
| McLennan, S | 1 |
| Handelsman, DJ | 1 |
| Delbridge, L | 1 |
| Reeve, T | 1 |
| Turtle, JR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acetylsalicylic Acid Administered in Patients With Type 2 Diabetes Mellitus and Its Effect on the Antioxidant Enzyme System[NCT03341117] | Phase 3 | 21 participants (Actual) | Interventional | 2014-12-02 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
25 other studies available for acetaminophen and Alloxan Diabetes
| Article | Year |
|---|---|
Ultra-Fast Insulin-Pramlintide Co-Formulation for Improved Glucose Management in Diabetic Rats.
Topics: Acetaminophen; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Compounding; Gastric Em | 2021 |
Determination of CYP450 activities in diabetes mellitus rats by a UHPLC-MS/MS method.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P- | 2023 |
Determination of CYP450 activities in diabetes mellitus rats by a UHPLC-MS/MS method.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P- | 2023 |
Determination of CYP450 activities in diabetes mellitus rats by a UHPLC-MS/MS method.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P- | 2023 |
Determination of CYP450 activities in diabetes mellitus rats by a UHPLC-MS/MS method.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P- | 2023 |
Antidiabetic and hepatoprotective potential of whole plant extract and isolated compounds of Aeginetia indica.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Diabetes M | 2020 |
Ameliorative effect of berberine coated bio-active nanoparticles in acetaminophen induced hepato-renal damage in diabetic rats.
Topics: Acetaminophen; Animals; Antioxidants; Berberine; Diabetes Mellitus, Experimental; Drug Carriers; Kid | 2018 |
Protective effect of bark and empty pod extracts from Acacia auriculiformis against paracetamol intoxicated liver injury and alloxan induced type II diabetes.
Topics: Acacia; Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Alloxan; Animals; Aspartate Amino | 2013 |
Enhancement of Antihyperalgesia by the Coadministration of N-palmitoylethanolamide and Acetaminophen in Diabetic Rats.
Topics: Acetaminophen; Amides; Analgesics; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; | 2015 |
Antinociceptive effects of combination of tramadol and acetaminophen on painful diabetic neuropathy in streptozotocin-induced diabetic rats.
Topics: Acetaminophen; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Therapy, Combin | 2011 |
Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan.
Topics: Acetaminophen; Alloxan; Analgesics, Non-Narcotic; Animals; Aqueous Humor; Area Under Curve; Chromato | 2012 |
Type 1 diabetic mice are protected from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2003 |
Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity.
Topics: Acetaminophen; Animals; Cell Division; Chemical and Drug Induced Liver Injury; Colchicine; Cytochrom | 2003 |
Effects of an aldose reductase inhibitor on gastroenteropathy in streptozotocin-diabetic rats.
Topics: Acetaminophen; Aldehyde Reductase; Animals; Blood Glucose; Body Water; Colon; Diabetes Mellitus, Exp | 2003 |
Protective effect of type 2 diabetes on acetaminophen-induced hepatotoxicity in male Swiss-Webster mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Chromatogr | 2006 |
Acetaminophen normalizes glucose homeostasis in mouse models for diabetes.
Topics: Acetaminophen; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; D | 2008 |
Role of UDPGA flux in acetaminophen clearance and hepatotoxicity.
Topics: Absorption; Acetaminophen; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Dru | 1984 |
Increased resistance of diabetic rats to acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Experimental; Glu | 1982 |
Biochemical basis for dose response relationships in reactive metabolite toxicity.
Topics: Acetaminophen; Animals; Biotransformation; Cricetinae; Diabetes Mellitus, Experimental; Drug-Related | 1981 |
Gastric emptying in diabetic gastroparetic dogs: ffects of SK-951,a novel prokinetic agent.
Topics: Acetaminophen; Animals; Benzofurans; Blood Glucose; Body Weight; Bridged Bicyclo Compounds, Heterocy | 2001 |
Acetaminophen-induced glutathione depletion in diabetic rats.
Topics: Acetaminophen; Animals; Diabetes Mellitus, Experimental; Female; Glutathione; Liver; Oxidation-Reduc | 1979 |
Long-term diabetes alters the hepatobiliary clearance of acetaminophen, bilirubin and digoxin.
Topics: Acetaminophen; Animals; Bile; Bilirubin; Diabetes Mellitus, Experimental; Digoxin; Glucuronates; Ins | 1992 |
Prevention of cataract in diabetic rats by aspirin, paracetamol (acetaminophen) and ibuprofen.
Topics: Acetaminophen; Animals; Aspirin; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Female; G | 1992 |
The role of cytochrome P450IIE1 in bioactivation of acetaminophen in diabetic and acetone-treated mice.
Topics: Acetaminophen; Acetone; Animals; Biotransformation; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme | 1991 |
[Correlation between gastric emptying time and both plasma gastrin and pancreatic polypeptide in streptozotocin diabetic dogs].
Topics: Acetaminophen; Animals; Diabetes Mellitus, Experimental; Dogs; Gastric Emptying; Gastrins; Insulin; | 1989 |
Strain differences in susceptibility of normal and diabetic rats to acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Experimental; Dis | 1986 |
Biliary excretion of acetaminophen in diabetic and hyperthyroid rats.
Topics: Acetaminophen; Animals; Bile; Diabetes Mellitus, Experimental; Hyperthyroidism; Male; Rats; Rats, In | 1985 |
The effects of cyclooxygenase and lipoxygenase inhibitors on the collagen abnormalities of diabetic rats.
Topics: Acetaminophen; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Cyclooxygenase Inhib | 1985 |