acetaminophen has been researched along with Allergy, Drug in 139 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To classify patients with a history of aspirin-induced urticaria as cross-reactors or single-drug reactors by oral challenges with another strong COX-1 inhibitor, namely, ketoprofen." | 9.12 | Use of ketoprofen oral challenges to detect cross-reactors among patients with a history of aspirin-induced urticaria. ( Asero, R, 2006) |
| "One hundred and thirty-seven patients with nimesulide-induced urticaria were submitted to a single-blind, placebo-controlled peroral challenge with increasing doses of benzydamine." | 9.10 | Benzydamine: an alternative nonsteroidal anti-inflammatory drug in patients with nimesulide-induced urticaria. ( Di Paola, R; Ferrannini, A; Napoli, G; Nettis, E; Tursi, A, 2002) |
| "Acetaminophen was tolerated by all patients, whereas two experienced immediate systemic urticaria after the administration of 125 mg of aspirin." | 9.08 | Aspirin and paracetamol tolerance in patients with nimesulide-induced urticaria. ( Asero, R, 1998) |
| "Cross-sensitivity between aspirin and acetaminophen in aspirin-sensitive asthmatic patients has been reported with frequencies ranging from 0% to 29%." | 9.08 | Prevalence of cross-sensitivity with acetaminophen in aspirin-sensitive asthmatic subjects. ( Christiansen, SC; Mathison, DA; Schrank, PJ; Settipane, RA; Simon, RA; Stevenson, DD, 1995) |
| "Ten aspirin (ASA)-sensitive patients with asthma underwent double-blind, placebo-controlled oral challenges with salsalate followed by ASA-sensitive confirmatory challenges." | 9.06 | Salsalate cross-sensitivity in aspirin-sensitive patients with asthma. ( Goldlust, MB; Hougham, AJ; Schrank, PJ; Stevenson, DD; Wilson, RR, 1990) |
| "The primary outcome measure was the odds ratio (OR) of current asthma symptoms associated with acetaminophen use calculated by logistic regression." | 7.77 | Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International Study of Asthma and Allergies in Childhood Phase Three. ( Beasley, RW; Clayton, TO; Crane, J; Lai, CK; Montefort, SR; Mutius, Ev; Stewart, AW, 2011) |
| " At ages 1 and 3, questionnaire data were collected on wheeze, eczema, child's use of acetaminophen, and various potential confounders, along with a stool sample for geohelminth analysis." | 7.77 | The role of acetaminophen and geohelminth infection on the incidence of wheeze and eczema: a longitudinal birth-cohort study. ( Alem, A; Amberbir, A; Britton, J; Davey, G; Medhin, G; Venn, A, 2011) |
| "An acute anaphylactic reaction after a conventional antipyretic dose of ibuprofen was diagnosed in a child with allergic rhinitis, recurrent idiopathic urticaria, and nonimmunologic cross-reactive hypersensitivity to nonsteroidal antiinflammatory drugs and acetaminophen." | 7.74 | Severe anaphylactic reaction to ibuprofen in a child with recurrent urticaria. ( Chin, CW; Chong, NK; Hoon, LS; Hwee, CY; Kang, LW; Kidon, MI, 2007) |
| "The aim of this study was to evaluate whether an intraoperative bronchospasm is more frequent in sinus surgery than in non-sinus surgery, whether its appearance after application of a non-steroidal anti-inflammatory drug (NSAID) is an indicator of an aspirin intolerance syndrome, and whether its appearance can be interpreted as an aspirin provocation test." | 7.73 | [Intraoperative bronchospasm during paranasal sinus surgery -- indicator of aspirin intolerance syndrome?]. ( Blidaru, N; Keck, T; Polzehl, D; Rockemann, M; Rozsasi, A; Santak, B, 2006) |
| "We report an asthmatic adolescent female who had anaphylaxis with 650 mg acetaminophen after tolerating 325-mg doses for years." | 7.69 | Acetaminophen anaphylaxis with aspirin and sodium salicylate sensitivity: a case report. ( Ham Pong, A; Schwarz, N, 1996) |
| "To determine whether the different modes of action of aspirin and acetaminophen are associated with different incidences of bronchoconstriction, and whether there is cross-reactivity in terms of intolerance, selected asthmatics were challenged with both analgesics." | 7.66 | Acetaminophen and aspirin challenges in subgroups of asthmatics. ( Falliers, CJ, 1983) |
| "Acetaminophen is a widely used antipyretic drug." | 5.33 | Churg-Strauss syndrome associated with hypersensitivity to acetaminophen. ( Kawakami, M; Masuzawa, A; Moriguchi, M; Otsuka, M; Sugawara, H; Tabei, K; Tsuda, T; Yamada, S, 2005) |
| "To classify patients with a history of aspirin-induced urticaria as cross-reactors or single-drug reactors by oral challenges with another strong COX-1 inhibitor, namely, ketoprofen." | 5.12 | Use of ketoprofen oral challenges to detect cross-reactors among patients with a history of aspirin-induced urticaria. ( Asero, R, 2006) |
| "One hundred and thirty-seven patients with nimesulide-induced urticaria were submitted to a single-blind, placebo-controlled peroral challenge with increasing doses of benzydamine." | 5.10 | Benzydamine: an alternative nonsteroidal anti-inflammatory drug in patients with nimesulide-induced urticaria. ( Di Paola, R; Ferrannini, A; Napoli, G; Nettis, E; Tursi, A, 2002) |
| "Previous studies show skin reactions after exposure to acetaminophen and/or nimesulide to occur in about 10% of patients with a history of urticaria induced by aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs)." | 5.09 | Risk factors for acetaminophen and nimesulide intolerance in patients with NSAID-induced skin disorders. ( Asero, R, 1999) |
| "Acetaminophen was tolerated by all patients, whereas two experienced immediate systemic urticaria after the administration of 125 mg of aspirin." | 5.08 | Aspirin and paracetamol tolerance in patients with nimesulide-induced urticaria. ( Asero, R, 1998) |
| "Cross-sensitivity between aspirin and acetaminophen in aspirin-sensitive asthmatic patients has been reported with frequencies ranging from 0% to 29%." | 5.08 | Prevalence of cross-sensitivity with acetaminophen in aspirin-sensitive asthmatic subjects. ( Christiansen, SC; Mathison, DA; Schrank, PJ; Settipane, RA; Simon, RA; Stevenson, DD, 1995) |
| "Ten aspirin (ASA)-sensitive patients with asthma underwent double-blind, placebo-controlled oral challenges with salsalate followed by ASA-sensitive confirmatory challenges." | 5.06 | Salsalate cross-sensitivity in aspirin-sensitive patients with asthma. ( Goldlust, MB; Hougham, AJ; Schrank, PJ; Stevenson, DD; Wilson, RR, 1990) |
| "Although the use of acetaminophen is weakly associated with asthma/wheezing, the widespread use of the drug might have important public health implications." | 4.87 | Early exposure to acetaminophen and allergic disorders. ( Garcia-Marcos, L; Perez-Fernandez, V; Sanchez-Solis, M, 2011) |
| "Relevant articles in the medical literature were derived from searching the MEDLINE database with key terms aspirin-sensitive asthma, cyclo-oxygenase enzymes 1 and 2." | 4.81 | Sensitivity to nonsteroidal anti-inflammatory drugs. ( Namazy, JA; Simon, RA, 2002) |
| "We observed a positive relationship between acetaminophen and/or antibiotic exposure during the 1st year of life and the subsequent development of the three examined allergic diseases (atopic dermatitis, asthma and allergic rhinitis) in the 1998 birth cohort, but the observed relationship of drug exposure in the 2003 cohort, especially for atopic dermatitis and asthma, was lower than for those in the 1998 cohort and was not statistically significant." | 3.79 | Acetaminophen and/or antibiotic use in early life and the development of childhood allergic diseases. ( Chen, CY; Hsiung, CA; Huang, YW; Liu, LF; Tsai, HJ; Wang, JY, 2013) |
| " At ages 1 and 3, questionnaire data were collected on wheeze, eczema, child's use of acetaminophen, and various potential confounders, along with a stool sample for geohelminth analysis." | 3.77 | The role of acetaminophen and geohelminth infection on the incidence of wheeze and eczema: a longitudinal birth-cohort study. ( Alem, A; Amberbir, A; Britton, J; Davey, G; Medhin, G; Venn, A, 2011) |
| "The primary outcome measure was the odds ratio (OR) of current asthma symptoms associated with acetaminophen use calculated by logistic regression." | 3.77 | Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International Study of Asthma and Allergies in Childhood Phase Three. ( Beasley, RW; Clayton, TO; Crane, J; Lai, CK; Montefort, SR; Mutius, Ev; Stewart, AW, 2011) |
| "An acute anaphylactic reaction after a conventional antipyretic dose of ibuprofen was diagnosed in a child with allergic rhinitis, recurrent idiopathic urticaria, and nonimmunologic cross-reactive hypersensitivity to nonsteroidal antiinflammatory drugs and acetaminophen." | 3.74 | Severe anaphylactic reaction to ibuprofen in a child with recurrent urticaria. ( Chin, CW; Chong, NK; Hoon, LS; Hwee, CY; Kang, LW; Kidon, MI, 2007) |
| "The aim of this study was to evaluate whether an intraoperative bronchospasm is more frequent in sinus surgery than in non-sinus surgery, whether its appearance after application of a non-steroidal anti-inflammatory drug (NSAID) is an indicator of an aspirin intolerance syndrome, and whether its appearance can be interpreted as an aspirin provocation test." | 3.73 | [Intraoperative bronchospasm during paranasal sinus surgery -- indicator of aspirin intolerance syndrome?]. ( Blidaru, N; Keck, T; Polzehl, D; Rockemann, M; Rozsasi, A; Santak, B, 2006) |
| "Post-anesthesia anaphylactic reactions or those seen during drug provocation tests with a systemic clinical reaction may be confirmed by the sequential release into blood of plasma histamine, tryptase and leukotriene C4 and into urine of urinary methylhistamine and leukotriene E4." | 3.70 | [Importance of the urinary leukotriene E4 level. Preliminary study]. ( Drouet, M; el Founini, M; Sabbah, A, 1998) |
| "We report an asthmatic adolescent female who had anaphylaxis with 650 mg acetaminophen after tolerating 325-mg doses for years." | 3.69 | Acetaminophen anaphylaxis with aspirin and sodium salicylate sensitivity: a case report. ( Ham Pong, A; Schwarz, N, 1996) |
| "To determine whether the different modes of action of aspirin and acetaminophen are associated with different incidences of bronchoconstriction, and whether there is cross-reactivity in terms of intolerance, selected asthmatics were challenged with both analgesics." | 3.66 | Acetaminophen and aspirin challenges in subgroups of asthmatics. ( Falliers, CJ, 1983) |
| "Challenge tests with some analgesics in common use were performed in five aspirin-sensitive asthmatics." | 3.65 | Response of aspirin-allergic patients to challenge by some analgesics in common use. ( Smith, AP, 1971) |
| "Ibuprofen was the most commonly implicated drug, followed by acetylsalicylic acid (ASA)." | 2.76 | Response to a selective COX-2 inhibitor in patients with urticaria/angioedema induced by nonsteroidal anti-inflammatory drugs. ( Blanca, M; Blanca-López, N; Campo, P; Canto, G; Doña, I; Fernández, J; Gómez, AI; Jagemann, LR; Laguna, JJ; Rondón, C; Rosado, A; Torres, MJ, 2011) |
| " Thus, we conclude that CE is a reasonably safe alternative to be used in subjects who do not tolerate P and N." | 2.71 | Safety of celecoxib in patients with adverse skin reactions to acetaminophen (paracetamol) and nimesulide associated or not with common non-steroidal anti-inflammatory drugs. ( D'Amato, G; D'Amato, M; Liccardi, G; Piccolo, A; Piscitelli, E; Salzillo, A; Senna, G, 2005) |
| " Thus, we conclude that CE is a reasonably safe alternative which can be used in subjects who do not tolerate P." | 2.71 | Safety of celecoxib in patients with adverse skin reactions to acetaminophen (paracetamol) and other non-steroidal anti-inflammatory drugs. ( Cazzola, M; D'Amato, G; D'Amato, M; De Giglio, C; Liccardi, G; Manfredi, D; Piscitelli, E, 2005) |
| "High inter-individual variability in the production of reactive paracetamol metabolites exists, and factors leading to increased bioavailability of reactive paracetamol metabolites are being uncovered." | 2.58 | The potential role of pharmacogenomics and biotransformation in hypersensitivity reactions to paracetamol. ( Agúndez, JAG; García-Martin, E; Gómez-Tabales, J; Ruano, F, 2018) |
| "Fever and pain are the most common issues in pediatric patient management." | 2.36 | Use of antipyretic analgesics in the pediatric patient. ( Gladtke, E, 1983) |
| "Anaphylaxis is a life-threatening medical emergency." | 1.91 | Anaphylaxis following a pleural puncture bringing back a rock water-like liquid. ( Abdenadher, M; Ben Mansour, A; Ben Saad, S; Daghfous, H; Neji, H; Slim, A; Tritar, F, 2023) |
| "Selective COX-2 inhibitor NSAIDs are safe in patients with N-ERD." | 1.72 | Which non-steroidal anti-inflammatory drug (NSAID) is safer in patients with Non-steroids Exacerbated Respiratory Disease (N-ERD)? A single-center retrospective study. ( Çakmak, ME, 2022) |
| "Anaphylactoid reactions are well-documented adverse events associated with the intravenous administration of N-acetylcysteine (NAC) in patients with acetaminophen overdose." | 1.62 | A Case Report of a Severe, Unusually Delayed Anaphylactoid Reaction to Intravenous N-Acetylcysteine During Treatment of Acute Acetaminophen Toxicity in an Adolescent. ( Cao, DJ; Epperson, LC; Weiss, ST, 2021) |
| " Les sensibilité et spécificité du dosage des IgE spécifiques pour le paracétamol, les tests cutanés et les autres tests de provocation in vitro ont été très peu étudiés." | 1.51 | [How I explore... a suspicion of paracetamol allergy in children]. ( El Abd, K; Gadisseur, R; Sciacca, M; Thimmesch, M, 2019) |
| "Ibuprofen was involved in all reactions." | 1.43 | [Hypersensitivity reactions to non-steroidal anti-inflammatory drugs and tolerance to alternative drugs]. ( Calvo Campoverde, K; Giner-Muñoz, MT; Lozano Blasco, J; Machinena, A; Martínez Valdez, L; Plaza, AM; Rojas Volquez, M, 2016) |
| "The prevalence of asthma, eczema and hay fever was 1." | 1.37 | Frequent use of paracetamol and risk of allergic disease among women in an Ethiopian population. ( Amberbir, A; Britton, J; Davey, G; Hanlon, C; Medhin, G; Venn, A, 2011) |
| " C3H/HeOuJ mice were dosed by oral gavage with diclofenac (DF), APAP, AMAP, OFLX, MET, or CMZ." | 1.37 | Oral exposure to drugs with immune-adjuvant potential induces hypersensitivity responses to the reporter antigen TNP-OVA. ( Bleumink, R; Boon, L; Fiechter, D; Hassing, I; Kwast, LM; Ludwig, IS; Pieters, RH, 2011) |
| "Acetaminophen is a widely used antipyretic drug." | 1.33 | Churg-Strauss syndrome associated with hypersensitivity to acetaminophen. ( Kawakami, M; Masuzawa, A; Moriguchi, M; Otsuka, M; Sugawara, H; Tabei, K; Tsuda, T; Yamada, S, 2005) |
| "Intravenous administration of an oral solution of N-acetylcysteine is associated with a low rate of adverse events and should be considered for selected patients with suspected acetaminophen poisoning." | 1.32 | What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning? ( Brizendine, EJ; Furbee, RB; Kao, LW; Kirk, MA; Mehta, NH; Skinner, JR, 2003) |
| "Acetaminophen (paracetamol) is an analgesic antipyretic drug with no antiinflammatory effects and is widely used worldwide." | 1.31 | Paracetamol (acetaminophen) hypersensitivity. ( Camo, IP; Cosmes, EL; Cuevas, M; de Paramo, BJ; Gancedo, SQ; Martin, JA, 2000) |
| "A case of an anaphylactoid reaction to paracetamol is described." | 1.31 | Anaphylactoid reactions to paracetamol. ( Ayonrinde, OT; Saker, BM, 2000) |
| "Thirty-five patients had proven drug allergy; 33 were not allergic to drugs and served as a control group together with 40 other subjects with no history of drug allergy." | 1.30 | Predictive capacity of histamine release for the diagnosis of drug allergy. ( Bousquet, J; Daurès, JP; Demoly, P; Godard, P; Lebel, B; Messaad, D; Rongier, M; Sahla, H, 1999) |
| "Diclofenac was administered to rats by gastric gavage." | 1.30 | Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: possible role in allergic reactions. ( Graf, ML; Lustberg, LR; Martin, BM; Pohl, LR; Ware, JA, 1998) |
| "Acetaminophen levels were determined in 1,176 sera separated from donated blood." | 1.26 | Incidence of acetaminophen in donated blood. ( Kidroni, G; Menczel, J; Sharon, R, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (28.06) | 18.7374 |
| 1990's | 23 (16.55) | 18.2507 |
| 2000's | 38 (27.34) | 29.6817 |
| 2010's | 28 (20.14) | 24.3611 |
| 2020's | 11 (7.91) | 2.80 |
| Authors | Studies |
|---|---|
| Pascal, B | 1 |
| Evrard, B | 1 |
| Merlin, E | 1 |
| Egron, C | 1 |
| Bonnet, B | 1 |
| Michaud, E | 1 |
| Çakmak, ME | 1 |
| Ben Saad, S | 1 |
| Ben Mansour, A | 1 |
| Slim, A | 1 |
| Neji, H | 1 |
| Abdenadher, M | 1 |
| Daghfous, H | 1 |
| Tritar, F | 1 |
| Suh, J | 1 |
| Slawski, BR | 1 |
| Long, AA | 1 |
| Guidon, AC | 1 |
| Muzammil, M | 1 |
| Aziz, K | 1 |
| Ehteram Ul Haq, M | 1 |
| Nasir, N | 1 |
| Kakolyri, M | 1 |
| Strikou, F | 1 |
| Kavallari, A | 1 |
| Chliva, C | 1 |
| Makris, M | 1 |
| Tiligada, E | 1 |
| Topal, OY | 1 |
| Ilknur, KC | 1 |
| Irem, YT | 1 |
| Muge, T | 1 |
| Ersoy, C | 1 |
| Betul, K | 1 |
| Emine, DM | 1 |
| Sipahi Cimen, S | 1 |
| Yucel, E | 1 |
| Ozceker, D | 1 |
| Suleyman, A | 1 |
| Hizli Demirkale, Z | 1 |
| Sayili, U | 1 |
| Guler, N | 1 |
| Ozdemir, C | 1 |
| Tamay, ZU | 1 |
| Epperson, LC | 1 |
| Weiss, ST | 1 |
| Cao, DJ | 1 |
| Li, PH | 1 |
| Dellemin, NA | 1 |
| Zahari, Z | 1 |
| Ahmad Hassali, MA | 1 |
| Rashid, SA | 1 |
| Liccioli, G | 1 |
| Filippeschi, C | 1 |
| Giovannini, M | 1 |
| Capone, M | 1 |
| Oranges, T | 1 |
| Barni, S | 1 |
| Sarti, L | 1 |
| Parronchi, P | 1 |
| Mori, F | 1 |
| Teles, A | 1 |
| Ribeiro-Mourão, F | 1 |
| Branco, M | 1 |
| Araújo, AR | 1 |
| Vieira, T | 1 |
| Gabrielli, S | 1 |
| Langlois, A | 1 |
| Ben-Shoshan, M | 1 |
| Agúndez, JAG | 1 |
| Gómez-Tabales, J | 1 |
| Ruano, F | 1 |
| García-Martin, E | 1 |
| Rodríguez-Fernández, A | 1 |
| Sánchez-Domínguez, M | 1 |
| Noguerado-Mellado, B | 1 |
| Rojas-Pérez-Ezquerra, P | 1 |
| Thimmesch, M | 1 |
| Sciacca, M | 1 |
| Gadisseur, R | 1 |
| El Abd, K | 1 |
| Thompson, G | 1 |
| Bundell, C | 1 |
| Lucas, M | 1 |
| Schmidt, LE | 1 |
| Coulson, JM | 1 |
| Thompson, JP | 1 |
| Wang, JY | 1 |
| Liu, LF | 1 |
| Chen, CY | 1 |
| Huang, YW | 1 |
| Hsiung, CA | 1 |
| Tsai, HJ | 1 |
| Asero, R | 4 |
| Barbarroja-Escudero, J | 1 |
| Sanchez-Gonzalez, MJ | 1 |
| Rodriguez-Rodriguez, M | 1 |
| Antolin-Amerigo, D | 1 |
| Vélez, D | 1 |
| Medina-Exposito, I | 1 |
| Sanchez-Gomez-Aparici, E | 1 |
| Piteiro, AB | 1 |
| Alvarez-Mon, M | 1 |
| Calvo Campoverde, K | 1 |
| Giner-Muñoz, MT | 1 |
| Martínez Valdez, L | 1 |
| Rojas Volquez, M | 1 |
| Lozano Blasco, J | 1 |
| Machinena, A | 1 |
| Plaza, AM | 1 |
| Jain, SS | 1 |
| Green, S | 1 |
| Rose, M | 1 |
| Thompson, RA | 1 |
| Isin, EM | 1 |
| Ogese, MO | 1 |
| Mettetal, JT | 1 |
| Williams, DP | 1 |
| Kwast, L | 1 |
| Fiechter, D | 2 |
| Kruijssen, L | 1 |
| Bleumink, R | 2 |
| Ludwig, I | 1 |
| Bol-Schoenmakers, M | 1 |
| Smit, J | 1 |
| Pieters, R | 1 |
| Dass, K | 1 |
| Bose, S | 1 |
| Ditto, AM | 1 |
| Numata, T | 1 |
| Fukushi, R | 1 |
| Ito, T | 1 |
| Tsuboi, R | 1 |
| Harada, K | 1 |
| Dennis, MJ | 1 |
| Panchabhai, TS | 1 |
| Gogtay, NJ | 1 |
| Bavdekar, SB | 1 |
| López Abad, R | 1 |
| Iriarte Sotés, P | 1 |
| Castro Murga, M | 1 |
| Gracia Bara, MT | 1 |
| Sesma Sánchez, P | 1 |
| Beasley, RW | 1 |
| Clayton, TO | 1 |
| Crane, J | 1 |
| Lai, CK | 1 |
| Montefort, SR | 1 |
| Mutius, Ev | 1 |
| Stewart, AW | 1 |
| Amberbir, A | 2 |
| Medhin, G | 2 |
| Alem, A | 1 |
| Britton, J | 2 |
| Davey, G | 2 |
| Venn, A | 2 |
| Kwast, LM | 1 |
| Hassing, I | 1 |
| Boon, L | 1 |
| Ludwig, IS | 1 |
| Pieters, RH | 1 |
| Garcia-Marcos, L | 1 |
| Sanchez-Solis, M | 1 |
| Perez-Fernandez, V | 1 |
| Chang, KC | 1 |
| Leung, CC | 1 |
| Tam, CM | 1 |
| Kong, FY | 1 |
| Sabaté, M | 1 |
| Ibáñez, L | 1 |
| Pérez, E | 1 |
| Vidal, X | 1 |
| Buti, M | 1 |
| Xiol, X | 1 |
| Mas, A | 1 |
| Guarner, C | 1 |
| Forné, M | 1 |
| Solà, R | 1 |
| Castellote, J | 1 |
| Rigau, J | 1 |
| Laporte, JR | 1 |
| Hanlon, C | 1 |
| Doña, I | 1 |
| Blanca-López, N | 1 |
| Jagemann, LR | 1 |
| Torres, MJ | 1 |
| Rondón, C | 1 |
| Campo, P | 1 |
| Gómez, AI | 1 |
| Fernández, J | 1 |
| Laguna, JJ | 1 |
| Rosado, A | 1 |
| Blanca, M | 2 |
| Canto, G | 1 |
| Rutkowski, K | 1 |
| Nasser, SM | 1 |
| Ewan, PW | 1 |
| Couto, M | 1 |
| Gaspar, A | 2 |
| Morais-Almeida, M | 2 |
| Kvedariene, V | 1 |
| Bencherioua, AM | 1 |
| Messaad, D | 2 |
| Godard, P | 2 |
| Bousquet, J | 2 |
| Demoly, P | 2 |
| Namazy, JA | 1 |
| Simon, RA | 2 |
| Kao, LW | 1 |
| Kirk, MA | 1 |
| Furbee, RB | 1 |
| Mehta, NH | 1 |
| Skinner, JR | 1 |
| Brizendine, EJ | 1 |
| Morgan, S | 1 |
| Dorman, S | 1 |
| Gamboa, P | 1 |
| Sanz, ML | 1 |
| Caballero, MR | 1 |
| Urrutia, I | 1 |
| Antépara, I | 1 |
| Esparza, R | 1 |
| de Weck, AL | 2 |
| Sedinkin, AA | 1 |
| Balandin, AV | 1 |
| Dimova, AD | 1 |
| Falliers, CJ | 3 |
| Liccardi, G | 2 |
| Salzillo, A | 1 |
| Piccolo, A | 1 |
| Senna, G | 1 |
| Piscitelli, E | 2 |
| D'Amato, M | 2 |
| D'Amato, G | 2 |
| Masuzawa, A | 1 |
| Moriguchi, M | 1 |
| Tsuda, T | 1 |
| Sugawara, H | 1 |
| Otsuka, M | 1 |
| Yamada, S | 1 |
| Tabei, K | 1 |
| Kawakami, M | 1 |
| Boussetta, K | 1 |
| Ponvert, C | 1 |
| Karila, C | 1 |
| Bourgeois, ML | 1 |
| Blic, J | 1 |
| Scheinmann, P | 1 |
| McAlinden, RL | 1 |
| Ellis, PE | 1 |
| Sandy, JR | 1 |
| Kidon, MI | 3 |
| Kang, LW | 2 |
| Chin, CW | 2 |
| Hoon, LS | 2 |
| See, Y | 1 |
| Goh, A | 2 |
| Lin, JT | 1 |
| Chay, OM | 2 |
| Iancovici Kidon, M | 1 |
| Abramovitch, I | 1 |
| Steinberg, S | 1 |
| Barash, J | 1 |
| Cazzola, M | 1 |
| De Giglio, C | 1 |
| Manfredi, D | 1 |
| Rozsasi, A | 1 |
| Blidaru, N | 1 |
| Rockemann, M | 1 |
| Santak, B | 1 |
| Polzehl, D | 1 |
| Keck, T | 1 |
| Komericki, P | 1 |
| Arbab, E | 1 |
| Grims, R | 1 |
| Kränke, B | 1 |
| Aberer, W | 1 |
| Ikeda, T | 1 |
| Roll, A | 1 |
| Wüthrich, B | 1 |
| Schmid-Grendelmeier, P | 1 |
| Hofbauer, G | 1 |
| Ballmer-Weber, BK | 1 |
| Tsujino, Y | 1 |
| Okamoto, N | 1 |
| Morita, E | 1 |
| Sood, JD | 1 |
| Empson, M | 1 |
| Fitzharris, P | 1 |
| Stewart, J | 1 |
| Matsuno, O | 1 |
| Okubo, T | 1 |
| Hiroshige, S | 1 |
| Takenaka, R | 1 |
| Ono, E | 1 |
| Ueno, T | 1 |
| Nureki, S | 1 |
| Ando, M | 1 |
| Miyazaki, E | 1 |
| Kumamoto, T | 1 |
| Liew, WK | 1 |
| Chiang, WC | 1 |
| Lim, SH | 1 |
| Tang, JP | 1 |
| Cabrerizo Ballesteros, S | 1 |
| Méndez Alcalde, JD | 1 |
| Sánchez Alonso, A | 1 |
| Marinho, S | 1 |
| Hwee, CY | 1 |
| Chong, NK | 1 |
| Petitpain, N | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| N-Acetylcysteine to Prevent Radiocontrast Nephropathy in Emergency Department Patients[NCT00780962] | Phase 2 | 399 participants (Actual) | Interventional | 2007-10-16 | Completed | ||
| Randomized Placebo Controlled Trial of Intravenous N-Acetylcysteine for the Treatment of Acute Ischemic Stroke[NCT04918719] | Phase 2 | 118 participants (Anticipated) | Interventional | 2021-06-01 | Not yet recruiting | ||
| 13C-Methacetin Breath Test for the Prediction of Outcome in in Acute Liver Injury or Acute Liver Failure[NCT02786836] | Phase 2/Phase 3 | 76 participants (Actual) | Interventional | 2016-06-10 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Contrast-induced nephropathy was defined as an increase in serum creatinine level of greater than or equal to 0.5 mg/dL or an increase of 25% above baseline. The primary outcome was measured by the change in serum creatinine level from the pre-radiocontrast baseline to the serum creatinine level measured 48 to 72 hours after radiocontrast administration. (NCT00780962)
Timeframe: 48-72 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| N-Acetycysteine Group | 14 |
| 0.9% Sodium-chloride Group | 12 |
The relationship between the cPDR (cumulative PDR of metabolized 13C-Methacetin 20 minutes after ingestion) in single time points of MBT measurements and TFS and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: The first MBT reading either on Day 1 or Day 2 and Day 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Day 1 or 2 MBT/transplant free survival at Day 21 | Day 1 or 2 MBT & Day 21 non-TFS | |
| 13C-Methacetin Breath Test (MBT) | 1.4 | 0.2 |
Peak PDR is the maximal percent dose recovery (PDR) rate which reflects the maximum rate of metabolism of 13C-methacetin measured as the change in 13CO2 / 12CO2 (normal carbon dioxide) ratio after ingestion of 13C-methacetin normalized using the patient's height and weight. The distributions of mean PDR Peak values were compared between TFS (transplant free survival) and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: Days 1 and 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Mean Peak PDR for TFS subjects at Day 21 | Mean Peak PDR for non-TFS subjects at Day 21 | |
| 13C-Methacetin Breath Test (MBT) | 10.2 | 1.9 |
This outcome is similar to the peak PDR defined in the primary outcome but as a secondary we are looking at Day 1 or Day 2 peak PDR values. Peak PDR is the maximal percent dose recovery (PDR) rate which reflects the maximum rate of metabolism of 13C-methacetin measured as the change in 13CO2 / 12CO2 ratio after ingestion of 13C-methacetin normalized using the patient's height and weight. The distributions of mean PDR Peak values were compared between TFS and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: The first MBT reading either on Day 1 or Day 2 and Day 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Day 1 or 2 MBT & Day 21 TFS | Day 1 or 2 MBT & Day 21 non-TFS | |
| 13C-Methacetin Breath Test (MBT) | 9.1 | 2.3 |
20 reviews available for acetaminophen and Allergy, Drug
| Article | Year |
|---|---|
Prevalence of Hypersensitivity Reactions in Children Associated with Acetaminophen: A Systematic Review and Meta-Analysis.
Topics: Acetaminophen; Child; Drug Hypersensitivity; Humans; Male; Prevalence | 2018 |
The potential role of pharmacogenomics and biotransformation in hypersensitivity reactions to paracetamol.
Topics: Acetaminophen; Biological Variation, Population; Biotransformation; Cytochrome P-450 Enzyme System; | 2018 |
Paracetamol allergy in clinical practice.
Topics: Acetaminophen; Allergy and Immunology; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivit | 2019 |
Reactive Metabolites: Current and Emerging Risk and Hazard Assessments.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Second-Generation; Chemical | 2016 |
Acetaminophen anaphylaxis diagnosed by skin prick test.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anaphylaxis; Drug Hypersensitivity; Female; Humans; Skin Te | 2016 |
Early exposure to acetaminophen and allergic disorders.
Topics: Acetaminophen; Asthma; Drug Hypersensitivity; Female; Humans; Maternal Exposure; Pregnancy; Prenatal | 2011 |
Selective anaphylaxis to paracetamol in a child.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anaphylaxis; Drug Hypersensitivity; Humans; Imm | 2012 |
Sensitivity to nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Adult; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Bleedin | 2002 |
[Drug-induced liver injury].
Topics: Acetaminophen; Anesthetics, General; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; | 2006 |
Nonprescription analgesics.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Inj | 1983 |
Use of antipyretic analgesics in the pediatric patient.
Topics: Acetaminophen; Adolescent; Agranulocytosis; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemic | 1983 |
Analgesic-antipyretic choices for children with asthma: a review of safety and risk of common preparations.
Topics: Acetaminophen; Adolescent; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Br | 1984 |
The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Chemical and Drug Induced Liver Injury; Cytochrome P-450 | 1995 |
ABC of diseases of liver, pancreas, and biliary system. Other causes of parenchymal liver disease.
Topics: Acetaminophen; Cholangitis, Sclerosing; Cholestasis; Drug Hypersensitivity; Hemochromatosis; Hepatit | 2001 |
Drug metabolism in the production of liver injury.
Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injur | 1975 |
Metabolic activation: biochemical basis for many drug-induced liver injuries.
Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hyp | 1976 |
Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma.
Topics: Acetaminophen; Adult; Aged; Aspirin; Asthma; Desensitization, Immunologic; Double-Blind Method; Drug | 1989 |
Non-steroidal and analgesic therapy in the elderly.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Cen | 1986 |
[Toxic hepatitis induced by anti-inflammatory agents].
Topics: Acetaminophen; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensitivi | 1985 |
Nonsteroidal anti-inflammatory drugs (first of two parts).
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Aspirin; Bone Marrow; Drug Hypersensitivity; Gastric | 1974 |
14 trials available for acetaminophen and Allergy, Drug
| Article | Year |
|---|---|
Response to a selective COX-2 inhibitor in patients with urticaria/angioedema induced by nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Adolescent; Adult; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cycl | 2011 |
The accuracy of the diagnosis of suspected paracetamol (acetaminophen) hypersensitivity: results of a single-blinded trial.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Case-Control Studies; Child; Child | 2002 |
[Results of an open prospective controlled randomized comparative trial of efficacy and tolerance of sublingual tablets flurbiprofen (strepfen) and paracetamol in patients with throat pain in acute infectious-inflammatory diseases of the upper respiratory
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Hypersensitivity; Flurbiprofen; Humans; Pain; Prospect | 2004 |
Safety of celecoxib in patients with adverse skin reactions to acetaminophen (paracetamol) and nimesulide associated or not with common non-steroidal anti-inflammatory drugs.
Topics: Acetaminophen; Adolescent; Adult; Aged; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Celecox | 2005 |
Safety of celecoxib in patients with adverse skin reactions to acetaminophen (paracetamol) and other non-steroidal anti-inflammatory drugs.
Topics: Acetaminophen; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase | 2005 |
Use of ketoprofen oral challenges to detect cross-reactors among patients with a history of aspirin-induced urticaria.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroida | 2006 |
Tolerance to celecoxib in patients with a history of adverse reactions to nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2006 |
Prevalence of cross-sensitivity with acetaminophen in aspirin-sensitive asthmatic subjects.
Topics: Acetaminophen; Adult; Aged; Aspirin; Asthma; Cross Reactions; Dose-Response Relationship, Immunologi | 1995 |
Aspirin and paracetamol tolerance in patients with nimesulide-induced urticaria.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibit | 1998 |
Risk factors for acetaminophen and nimesulide intolerance in patients with NSAID-induced skin disorders.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Bacterial | 1999 |
Benzydamine: an alternative nonsteroidal anti-inflammatory drug in patients with nimesulide-induced urticaria.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzydamin | 2002 |
Intolerance to piroxicam in patients with adverse reactions to nonsteroidal antiinflammatory drugs.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Drug Hypersensitivity; Drug | 1992 |
Salsalate cross-sensitivity in aspirin-sensitive patients with asthma.
Topics: Acetaminophen; Administration, Oral; Aspirin; Asthma; Double-Blind Method; Drug Hypersensitivity; Fo | 1990 |
Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma.
Topics: Acetaminophen; Adult; Aged; Aspirin; Asthma; Desensitization, Immunologic; Double-Blind Method; Drug | 1989 |
106 other studies available for acetaminophen and Allergy, Drug
| Article | Year |
|---|---|
Drug-induced enterocolitis syndrome with paracetamol (acetaminophen) in a 12-month-old boy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Hypersensitivity; Enterocolitis; Humans; Infant; Male; | 2022 |
Which non-steroidal anti-inflammatory drug (NSAID) is safer in patients with Non-steroids Exacerbated Respiratory Disease (N-ERD)? A single-center retrospective study.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitor | 2022 |
Anaphylaxis following a pleural puncture bringing back a rock water-like liquid.
Topics: Acetaminophen; Adolescent; Anaphylaxis; Drug Hypersensitivity; Female; Humans; Pleura; Punctures | 2023 |
Rituximab desensitization in two patients with muscle-specific kinase myasthenia gravis.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Autoantibodies; Desensitiz | 2019 |
Iron III isomaltose induced hypersensitivity reaction.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Drug Hypersensitivity; Dys | 2019 |
Increased Basal Blood Histamine Levels in Patients with Self-Reported Hypersensitivity to Non-Steroidal Anti-Inflammatory Drugs.
Topics: Acetaminophen; Adult; Aged; Allergens; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cyclooxy | 2020 |
Negative predictive value of provocation tests for nonsteroidal anti-inflammatory drugs in children.
Topics: Acetaminophen; Administration, Oral; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Child; Chi | 2020 |
Behind the scene: Paracetamol hypersensitivity in children.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Drug Hypersensitivity; Humans; Skin T | 2021 |
A Case Report of a Severe, Unusually Delayed Anaphylactoid Reaction to Intravenous N-Acetylcysteine During Treatment of Acute Acetaminophen Toxicity in an Adolescent.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anaphy | 2021 |
Skin testing for hypersensitivity and cross-reactivity between proton pump inhibitors.
Topics: Acetaminophen; Adult; Cross Reactions; Diagnosis, Differential; Drug Hypersensitivity; Drug Therapy, | 2020 |
A cross sectional study on assessing the knowledge, attitude and perception towards allergic reactions of paracetamol in Malaysia.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Cross-Sectional Studies; Drug Hypersensi | 2020 |
Mycoplasma pneumoniae-associated mucocutaneous disease in children: A case series with allergy workup in a tertiary care paediatric hospital.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Child; Child, Preschool; | 2021 |
Paracetamol Allergy: A Case of a 9-Year-Old Female with a History of Atopy.
Topics: Acetaminophen; Child; Drug Hypersensitivity; Female; Humans; Hypersensitivity, Immediate; Intraderma | 2021 |
Flare-Up Phenomenon of Intradermal Test with Anaphylactic Reaction to Paracetamol (Acetaminophen).
Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Aged, 80 and over; Allergens; Anap | 2019 |
[How I explore... a suspicion of paracetamol allergy in children].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Drug Hypersensitivity; Humans | 2019 |
Identification of patients at risk of anaphylactoid reactions to N-acetylcysteine in the treatment of paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Drug Hyperse | 2013 |
Anaphylactoid reactions to N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Drug Hypersensitivi | 2013 |
Acetaminophen and/or antibiotic use in early life and the development of childhood allergic diseases.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Asthma; Child; Child, Preschool; Der | 2013 |
Multiple nonsteroidal anti-inflammatory drug-induced cutaneous disease: what differentiates patients with and without underlying chronic spontaneous urticaria?
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroida | 2014 |
Fixed drug urticaria: a report of two patients.
Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Drug Hype | 2015 |
[Hypersensitivity reactions to non-steroidal anti-inflammatory drugs and tolerance to alternative drugs].
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Drug Substitution; Hu | 2016 |
Anaphylaxis following intravenous paracetamol: the problem is the solution.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anaphylaxis; Drug Hypersensitivity; Female; Hu | 2015 |
Oral exposure to immunostimulating drugs results in early changes in innate immune parameters in the spleen.
Topics: Acetaminophen; Adaptive Immunity; Administration, Oral; Animals; Carbamazepine; Cells, Cultured; Dic | 2016 |
An unusual case of immediate hypersensitivity reaction to a common medication.
Topics: Acetaminophen; Administration, Oral; Adult; Anaphylaxis; Desensitization, Immunologic; Drug Hypersen | 2016 |
Pain management for dentists.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspiri | 2008 |
Paracetamol induced angioedema.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Angioedema; Child, Preschool; Drug Hypersensitivity; Humans | 2008 |
Fixed drug eruption induced by phenylephrine: a case of polysensitivity.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Bronchial Provocation Tests; Common Cold; Cross Reac | 2009 |
Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International Study of Asthma and Allergies in Childhood Phase Three.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Asthma; Causality; Cohort Studies; Conjunctivit | 2011 |
The role of acetaminophen and geohelminth infection on the incidence of wheeze and eczema: a longitudinal birth-cohort study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Causality; Child, Preschool; Cohort Studies; Comorbidity; D | 2011 |
Oral exposure to drugs with immune-adjuvant potential induces hypersensitivity responses to the reporter antigen TNP-OVA.
Topics: Acetaminophen; Acetanilides; Adjuvants, Immunologic; Administration, Oral; Animals; Antibody Formati | 2011 |
Acetaminophen and asthma: spurious association?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Bias; Child, Preschool; Dose-Response Relationship, | 2011 |
Paracetamol in therapeutic dosages and acute liver injury: causality assessment in a prospective case series.
Topics: Acetaminophen; Adolescent; Adult; Aged, 80 and over; Analgesics, Non-Narcotic; Drug Hypersensitivity | 2011 |
Frequent use of paracetamol and risk of allergic disease among women in an Ethiopian population.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Cohort Studies; Demography; Drug Hyperse | 2011 |
Paracetamol hypersensitivity: clinical features, mechanism and role of specific IgE.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Child; Drug Hypersensitivity; Fema | 2012 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana | 2003 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana | 2003 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana | 2003 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Ana | 2003 |
Paracetamol (acetaminophen) allergy.
Topics: Acetaminophen; Angioedema; Diagnosis, Differential; Drug Hypersensitivity; Humans; Male; Middle Aged | 2004 |
The flow-cytometric determination of basophil activation induced by aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is useful for in vitro diagnosis of the NSAID hypersensitivity syndrome.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Basophil Degra | 2004 |
Emergent asthma: endogenous, exogenous, or iatrogenous.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Child, Preschool; Cross-Secti | 2005 |
Churg-Strauss syndrome associated with hypersensitivity to acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Arteries; Biopsy; Chronic Disease; Churg-Strauss Syndrome; | 2005 |
Hypersensitivity reactions to paracetamol in children: a study of 25 cases.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Child; Child, Prescho | 2005 |
Report of an adverse incident in a randomized clinical trial.
Topics: Acetaminophen; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcotic; Child; Drug Hypers | 2005 |
Early presentation with angioedema and urticaria in cross-reactive hypersensitivity to nonsteroidal antiinflammatory drugs among young, Asian, atopic children.
Topics: Acetaminophen; Administration, Oral; Adolescent; Allergens; Angioedema; Anti-Inflammatory Agents, No | 2005 |
Cross-reactive hypersensitivity to COX inhibitors in a child with mild allergic rhinitis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Child; | 2005 |
[Intraoperative bronchospasm during paranasal sinus surgery -- indicator of aspirin intolerance syndrome?].
Topics: Acetaminophen; Adult; Aged; Algorithms; Anesthesia, General; Anti-Inflammatory Agents, Non-Steroidal | 2006 |
Tryptase as severity marker in drug provocation tests.
Topics: Acetaminophen; Adolescent; Adult; Aspirin; Diclofenac; Drug Hypersensitivity; Female; Humans; Lidoca | 2006 |
Acetaminophen-induced urticaria without aspirin intolerance.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dr | 2007 |
Too much of a good thing, is it bad? Adrenaline on trial.
Topics: Acetaminophen; Adult; Angioedema; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Combi | 2007 |
Drug-induced lymphocyte stimulation test is not useful for the diagnosis of drug-induced pneumonia.
Topics: Acetaminophen; Adult; Aged, 80 and over; Analgesics, Non-Narcotic; Bronchial Provocation Tests; Drug | 2007 |
Hypersensitivity to paracetamol in Asian children with early onset of nonsteroidal anti-inflammatory drug allergy.
Topics: Acetaminophen; Adolescent; Age of Onset; Anti-Inflammatory Agents, Non-Steroidal; Asia; Child; Child | 2007 |
Erythema multiforme to tetrazepam.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Benzodiazepines; D | 2007 |
Montelukast in 2 atopic patients with intolerance to nonsteroidal anti-inflammatory drugs and paracetamol: 5-year follow-up.
Topics: Acetaminophen; Acetates; Adult; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspi | 2007 |
Severe anaphylactic reaction to ibuprofen in a child with recurrent urticaria.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Child | 2007 |
Recurrent fever, chills, and arthralgia with local anesthetics containing epinephrine-metabisulfite.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anesthetics, Local; Arthralgia; Carticaine; Chills; | 2008 |
Anaphylactoid reaction to acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Drug Hypersensitivity; Female; Humans; Middle Aged | 1982 |
Hyperpyrexia, allergic-type response and death occurring with low-dose bleomycin administration.
Topics: Acetaminophen; Aged; Bleomycin; Dexamethasone; Dose-Response Relationship, Drug; Drug Hypersensitivi | 1980 |
Hypersensitivity-like reactions to N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Drug Hypersensitivity; Female; Humans; Injections, | 1984 |
Acetaminophen hypersensitivity resembling Kawasaki disease.
Topics: Acetaminophen; Diagnosis, Differential; Drug Hypersensitivity; Erythema Multiforme; Female; Humans; | 1984 |
Acetaminophen and aspirin challenges in subgroups of asthmatics.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anaphylaxis; Aspirin; Asthma; Bronchial Provocation Tests; D | 1983 |
Incidence of acetaminophen in donated blood.
Topics: Acetaminophen; Blood Donors; Chromatography, High Pressure Liquid; Colorimetry; Drug Hypersensitivit | 1982 |
Acetaminophen hypersensitivity and other analgesics.
Topics: Acetaminophen; Adult; Aged; Analgesics; Drug Hypersensitivity; Female; Humans; Male; Middle Aged | 1994 |
[Hypersensitivity to paracetamol].
Topics: Acetaminophen; Adult; Drug Eruptions; Drug Hypersensitivity; Female; Humans | 1993 |
Nearly fatal episodes of hypotension, flushing, and dyspnea in a 47-year-old woman.
Topics: Acetaminophen; Anaphylaxis; Diagnosis, Differential; Drug Hypersensitivity; Dyspnea; Female; Flushin | 1993 |
Delayed hypersensitivity reaction to paracetamol (acetaminophen).
Topics: Acetaminophen; Child; Child, Preschool; Dermatitis, Allergic Contact; Drug Hypersensitivity; Edema; | 1996 |
Acetaminophen anaphylaxis with aspirin and sodium salicylate sensitivity: a case report.
Topics: Acetaminophen; Adolescent; Anaphylaxis; Aspirin; Cross Reactions; Drug Hypersensitivity; Female; Hum | 1996 |
Acetaminophen-induced urticaria and tolerance of ibuprofen in an eight-year-old child.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Drug Hypers | 1997 |
Paracetamol (acetaminophen) hypersensitivity.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Antibodies, Anti-Idiotypic; Cyclooxygenase Inhibitor | 1997 |
Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: possible role in allergic reactions.
Topics: Acetaminophen; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrier Prote | 1998 |
Paracetamol sensitivity without aspirin intolerance.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dr | 1998 |
[Importance of the urinary leukotriene E4 level. Preliminary study].
Topics: Acetaminophen; Anaphylaxis; Anesthetics; Aspirin; Biomarkers; Chymases; Drug Hypersensitivity; Hista | 1998 |
A dose-dependent delayed hypersensitivity reaction to acetaminophen after repeated acetaminophen intoxications.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Drug Hypersensitivity; Expectorants; | 1998 |
Atopy and intolerance of antimicrobial drugs increase the risk of reactions to acetaminophen and nimesulide in patients allergic to nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Allergens; Anti-Inflammatory Agents, Non- | 1998 |
Acetaminophen hypersensitivity.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Aspirin; Drug Hypersensitivity; Humans | 1999 |
Predictive capacity of histamine release for the diagnosis of drug allergy.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Child; Drug | 1999 |
Acetaminophen-induced rhabdomyolysis.
Topics: Acetaminophen; Adolescent; Drug Hypersensitivity; Humans; Male; Rhabdomyolysis | 1999 |
Delayed-type hypersensitivity rash from paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Diagnosis, Differential; Drug Hypersensitivity; Female; Hea | 2000 |
Anaphylactoid reactions to paracetamol.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anaphylaxis; Drug Hypersensitivity; Female; Humans; R | 2000 |
Paracetamol (acetaminophen) hypersensitivity.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Drug Hypersensitivity; Female; Humans; Hyperse | 2000 |
Acute cholestatic hepatitis caused by a probable allergic reaction to paracetamol in an adolescent.
Topics: Acetaminophen; Acute Disease; Adolescent; Analgesics, Non-Narcotic; Bilirubin; Chemical and Drug Ind | 2001 |
A report of a rare immediate reaction after ingestion of acetaminophen.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Drug Hypersensitivity; Female; Humans; Hypersen | 2001 |
Clinical features and atopy profile in Turkish subjects with analgesic intolerance.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Analgesics, Non-Narcotic; Anti-Bacterial Agents; | 2002 |
Anaphylactoid reaction to N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Drug Hypersensitivity; Female; Humans | 1979 |
Causes of death in fulminant hepatic failure and relationship to quantitative histological assessment of parenchymal damage.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Amanita; Autopsy; Brain Edema; Drug Hypersensit | 1975 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Animals; Chemical and Drug Induced Liver Injury; Chronic Disease; Contraceptiv | 1979 |
Aspirin and concomitant idiosyncrasies in adult asthmatic patients.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Aspirin; Asthma; Azo Compounds; Drug H | 1979 |
Acute acetaminophen hypersensitivity in infancy.
Topics: Acetaminophen; Acute Disease; Drug Hypersensitivity; Humans; Infant; Infant, Newborn; Male | 1979 |
Borrelia recurrentis infection: single-dose antibiotic regimens and management of the Jarisch-Herxheimer reaction.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Drug Hypersensitivity | 1978 |
[Acetaminophen poisoning].
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Clinical Enzyme Tests; Drug Hypersensitivity; Human | 1978 |
Drug-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related | 1978 |
Serum ferritin in patients with iron overload and with acute and chronic liver diseases.
Topics: Acetaminophen; Alcoholism; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug | 1975 |
Letter: Rash, weakness, and acetaminophen.
Topics: Acetaminophen; Drug Hypersensitivity; Humans; Male; Middle Aged; Urticaria | 1975 |
The diagnosis of aspirin idiosyncrasy by analgesic challenge.
Topics: Acetaminophen; Adolescent; Adult; Aged; Airway Obstruction; Aspirin; Asthma; Drug Hypersensitivity; | 1976 |
[A case of acetaminophen-induced pneumonitis].
Topics: Acetaminophen; Adult; Alveolitis, Extrinsic Allergic; Drug Hypersensitivity; Female; Humans | 1992 |
Anaphylactic shock induced by paracetamol.
Topics: Acetaminophen; Anaphylaxis; Drug Hypersensitivity; Female; Humans; Middle Aged | 1990 |
Early indicators of prognosis in fulminant hepatic failure.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Child; Drug Hypersensitivity; Halothan | 1989 |
[Occurrence of drug reactions].
Topics: Acetaminophen; Adult; Anaphylaxis; Angioedema; Aspirin; Asthma; Drug Hypersensitivity; Emergencies; | 1986 |
Metabolic basis of adverse drug reactions.
Topics: Acetaminophen; Acetylation; Adrenergic beta-Antagonists; Adult; Age Factors; Child; Debrisoquin; Dru | 1986 |
Immediate adverse reactions to acetaminophen in children: evaluation of histamine release and spirometry.
Topics: Acetaminophen; Drug Hypersensitivity; Histamine; Humans; Spirometry | 1989 |
Drug induced hepatic damage.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Hypersensitivit | 1988 |
Rates of sensitivity reactions to aspirin: problems in interpreting the data.
Topics: Acetaminophen; Aspirin; Drug Hypersensitivity; Humans; Ibuprofen; Research Design | 1986 |
Prescribing analgesics.
Topics: Acetaminophen; Aged; Analgesics; Anticoagulants; Aspirin; Child; Codeine; Diflunisal; Drug Hypersens | 1985 |
Acute hypersensitivity reactions to paracetamol.
Topics: Acetaminophen; Adult; Aged; Drug Hypersensitivity; Female; Humans; Male; Middle Aged; Netherlands; T | 1985 |
[Sensitization to phenacetin: immunological aspects].
Topics: Acetaminophen; Adult; Aniline Compounds; Biopsy; Cells, Cultured; Drug Eruptions; Drug Hypersensitiv | 1973 |
Immune thrombocytopenia due to a drug metabolite.
Topics: Acetaminophen; Adult; Animals; Antigen-Antibody Reactions; Antigens; Blood Coagulation Tests; Chroma | 1972 |
Drug-induced bleeding.
Topics: Acetaminophen; Anemia, Aplastic; Anticoagulants; Aspirin; Blood Platelets; Bone Marrow; Capillary Fr | 1974 |
Aspirin gastritis examined with intragastric photography.
Topics: Acetaminophen; Adult; Antacids; Aspirin; Buffers; Drug Hypersensitivity; Drug Synergism; Female; Gas | 1969 |
Response of aspirin-allergic patients to challenge by some analgesics in common use.
Topics: Acetaminophen; Adult; Analgesics; Aspirin; Asthma; Dextropropoxyphene; Drug Hypersensitivity; Female | 1971 |