acetaminophen has been researched along with Alcoholism in 121 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "During the 10-year interval, 1543 patients were hospitalized for acetaminophen overdose; 34% were alcohol abusers, 3% had liver disease, and 13% overdosed unintentionally." | 7.74 | Impact of liver disease, alcohol abuse, and unintentional ingestions on the outcomes of acetaminophen overdose. ( Dean, S; Li, B; Myers, RP; Quan, H; Shaheen, AA, 2008) |
| " Both patients were chronic alcohol abusers and had taken therapeutic doses of acetaminophen for a couple of days." | 7.71 | [Acetaminophen use by chronic alcohol abusers: a therapeutic dose may be too much for the liver]. ( Janssens, AR; van Mil, AH, 2001) |
| " In summary, all methodologically sound studies available indicate that therapeutic dosing of paracetamol to the alcoholic patient is not associated with hepatic injury." | 6.41 | Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review. ( Dart, RC; Kuffner, EK; Rumack, BH, 2000) |
| "To determine if subjects with chronic alcoholism are predisposed to acetaminophen-induced hepatotoxicity, and to determine the contributing factors." | 3.74 | Acetaminophen usage patterns and concentrations of glutathione and gamma-glutamyl transferase in alcoholic subjects. ( Anderson, DC; Seifert, CF, 2007) |
| "During the 10-year interval, 1543 patients were hospitalized for acetaminophen overdose; 34% were alcohol abusers, 3% had liver disease, and 13% overdosed unintentionally." | 3.74 | Impact of liver disease, alcohol abuse, and unintentional ingestions on the outcomes of acetaminophen overdose. ( Dean, S; Li, B; Myers, RP; Quan, H; Shaheen, AA, 2008) |
| "The widespread practice of using a lower plasma paracetamol (acetaminophen) concentration threshold for the treatment of paracetamol poisoning in patients with chronic alcoholism has been introduced on the basis of anecdotal case reports." | 3.71 | Should a lower treatment line be used when treating paracetamol poisoning in patients with chronic alcoholism?: a case against. ( Dargan, PI; Jones, AL, 2002) |
| " Both patients were chronic alcohol abusers and had taken therapeutic doses of acetaminophen for a couple of days." | 3.71 | [Acetaminophen use by chronic alcohol abusers: a therapeutic dose may be too much for the liver]. ( Janssens, AR; van Mil, AH, 2001) |
| "We describe a patient with acute liver and renal failure secondary to acetaminophen and chronic alcohol abuse who was treated aggressively with oral acetylcysteine, continuous renal replacement therapy, glucose and branched-chain amino acid intravenous feeding and ventilatory support." | 3.71 | Is continuous veno-venous hemofiltration for acetaminophen-induced acute liver and renal failure worthwhile? ( Agarwal, R; Farber, MO, 2002) |
| " Acetaminophen clearance and its partial clearance to its major metabolites has been determined before and after 5 days treatment with the anti-alcohol abuse agent disulfiram (200 mg daily)." | 3.68 | The influence of disulfiram on acetaminophen metabolism in man. ( Jørgensen, L; Poulsen, HE; Ranek, L, 1991) |
| "Severe intoxication from excessive acetaminophen without suicidal intent occurred in three patients, all alcohol abusers, one with evidence of underlying cirrhosis." | 3.67 | Enhanced toxicity of acetaminophen in alcoholics: report of three cases. ( Gluskin, LE; Leist, MH; Payne, JA, 1985) |
| "A 38-yr-old woman who by history ingested 13 g methylphenobarbital, alcohol, and 6 g acetaminophen became comatose slowly over 4 d." | 3.66 | Impaired metabolism of methylphenobarbital after a combined drug overdose: treatment by resin hemoperfusion. ( Humphreys, M; Jacob, P; Pond, S; Tong, T; Weiss, R, 1982) |
| " However, the concentrations of APAP-CYS during therapeutic dosing, in cases of acetaminophen toxicity from repeated dosing and in cases of hepatic injury from non-acetaminophen hepatotoxins have not been well characterized." | 2.76 | Acetaminophen-cysteine adducts during therapeutic dosing and following overdose. ( Dart, RC; Green, JL; Heard, KJ; James, LP; Judge, BS; Rhyee, S; Zolot, L, 2011) |
| "Adult alcohol abusers with a current drinking episode longer than 7 days received either placebo or paracetamol 4 g/day for 5 days." | 2.75 | The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study. ( Brands, B; Dart, RC; Green, JL; Heard, K; Kuffner, EK; Sproule, B, 2010) |
| " Our hypothesis was that common liver tests would be unaffected by administration of the maximum recommended daily dosage of acetaminophen for 3 consecutive days to newly-abstinent alcoholic subjects." | 2.73 | The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study. ( Bogdan, GM; Dart, RC; Green, JL; Heard, K; Knox, PC; Kuffner, EK; Palmer, RB; Slattery, JT, 2007) |
| "We enrolled chronic alcohol abusers (defined as >or= 6 drinks daily for >or= 6 weeks) who had discontinued alcohol consumption 12 to 72 hours prior to enrollment." | 2.73 | Are recommended doses of acetaminophen hepatotoxic for recently abstinent alcoholics? A randomized trial. ( Bartels, S; Crosby, D; Richard, J; Sivilotti, M, 2008) |
| " In summary, all methodologically sound studies available indicate that therapeutic dosing of paracetamol to the alcoholic patient is not associated with hepatic injury." | 2.41 | Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review. ( Dart, RC; Kuffner, EK; Rumack, BH, 2000) |
| " Studies performed in both experimental animals and humans indicate that chronic alcohol use leads to a short-term, two- to threefold increase in hepatic content of cytochrome P4502E1, the major isoform responsible for the generation of the toxic metabolite from paracetamol, although increased oxidative metabolism of paracetamol at recommended doses has not been demonstrated clinically." | 2.41 | Alcohol exposure and paracetamol-induced hepatotoxicity. ( Riordan, SM; Williams, R, 2002) |
| "Acetaminophen was invariably taken for nonsuicidal intent." | 2.40 | Enhanced hepatotoxicity of acetaminophen in the alcoholic patient. Two case reports and a review of the literature. ( Johnston, SC; Pelletier, LL, 1997) |
| " The possible causes for the injury from ostensibly nontoxic drug levels appear to be either the induction by chronic alcohol intake of the cytochrome P-450 system responsible for converting acetaminophen to a toxic metabolite, or the effect of alcoholism and the associated malnutrition in reducing the glutathione concentration, responsible normally for preventing hepatotoxicity by conjugation with the toxic metabolite." | 2.37 | Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure. ( Adler, E; Benjamin, SB; Cuccherini, BA; Seeff, LB; Zimmerman, HJ, 1986) |
| "Acetaminophen was the most common etiology, but LT proceeded more frequently in the non-acetaminophen cohort (acetaminophen: 45/326 patients received LT, 13." | 1.35 | The utilization of liver transplantation in the management of acute liver failure: comparison between acetaminophen and non-acetaminophen etiologies. ( Bates, CM; Garden, OJ; Hayes, PC; Henderson, NC; Lee, A; Masterton, G; Pollok, A; Simpson, KJ; Wigmore, SJ, 2009) |
| "Forty-four (21." | 1.31 | Influence of acute and chronic alcohol intake on the clinical course and outcome in acetaminophen overdose. ( Bondesen, S; Christensen, E; Lee, WM; Ott, P; Schiødt, FV, 2002) |
| "A higher frequency of chronic alcohol abuse among the patients with accidental overdoses may be one explanation." | 1.30 | Acetaminophen toxicity in an urban county hospital. ( Casey, DL; Lee, WM; Rochling, FA; Schiødt, FV, 1997) |
| " Susceptibility is presumably caused by induction of cytochrome P-4502EI by ethanol and by depletion of glutathione (GSH) because of the effects of alcohol, the malnutrition often associated with alcoholism, and the depletion associated with chronic use of APAP and impaired glucuronidation caused by fasting perhaps as well." | 1.29 | Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure. ( Maddrey, WC; Zimmerman, HJ, 1995) |
| "Dextropropoxyphene has been increasingly prescribed as an analgesic in the UK, chiefly in the form of Distalgesic (dextropropoxyphene hydrochloride 32." | 1.27 | Dextropropoxyphene deaths: coroner's report. ( Whittington, RM, 1984) |
| " This could be due to an increased activation of the drug to a toxic metabolite or to a decreased capacity to detoxify the toxic metabolite by conjugation with glutathione (GSH)." | 1.27 | Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. ( Lauterburg, BH; Velez, ME, 1988) |
| "Since all these patients were alcohol abusers, and the reported paracetamol intake was not remarkably high, it seems reasonable to recommend that paracetamol should be prescribed with great caution to alcoholics, and absolutely not for continuous use." | 1.27 | Paracetamol medication and alcohol abuse: a dangerous combination for the liver and the kidney. ( Denison, H; Kaczynski, J; Wallerstedt, S, 1987) |
| " A significant reduction in the LD50 was seen in the alcohol-pretreated mice, and correlations were noted between histological findings in the liver and the LD50 data." | 1.26 | Potentiation of acetaminophen hepatotoxicity by alcohol. ( Holtzman, JL; Kromhout, JP; McClain, CJ; Peterson, FJ, 1980) |
| "We describe three cases of toxic hepatitis associated with the chronic ingestion of excessive doses of acetaminophen." | 1.26 | Chronic excessive acetaminophen use and liver damage. ( Anuras, S; Barker, JD; de Carle, DJ, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (37.19) | 18.7374 |
| 1990's | 34 (28.10) | 18.2507 |
| 2000's | 37 (30.58) | 29.6817 |
| 2010's | 5 (4.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bissell, BD | 1 |
| Davis, JE | 1 |
| Flannery, AH | 1 |
| Adkins, DA | 1 |
| Thompson Bastin, ML | 1 |
| Manchanda, A | 1 |
| Cameron, C | 1 |
| Robinson, G | 1 |
| Dickerson, DL | 1 |
| Schaepper, MA | 1 |
| Peterson, MD | 1 |
| Ashworth, MD | 1 |
| Louvet, A | 2 |
| Dharancy, S | 2 |
| Mathurin, P | 2 |
| Myers, RP | 2 |
| Shaheen, AA | 2 |
| Lee, WM | 5 |
| Larson, AM | 2 |
| Arenas, J | 1 |
| Simpson, KJ | 1 |
| Bates, CM | 1 |
| Henderson, NC | 1 |
| Wigmore, SJ | 1 |
| Garden, OJ | 1 |
| Lee, A | 1 |
| Pollok, A | 1 |
| Masterton, G | 1 |
| Hayes, PC | 1 |
| Dart, RC | 6 |
| Green, JL | 3 |
| Kuffner, EK | 4 |
| Heard, K | 2 |
| Sproule, B | 1 |
| Brands, B | 1 |
| Claridge, LC | 1 |
| Eksteen, B | 1 |
| Smith, A | 1 |
| Shah, T | 1 |
| Holt, AP | 1 |
| Heard, KJ | 1 |
| James, LP | 1 |
| Judge, BS | 1 |
| Zolot, L | 1 |
| Rhyee, S | 1 |
| Buckley, NA | 1 |
| Srinivasan, J | 1 |
| Dargan, PI | 2 |
| Jones, AL | 2 |
| Łukasik-Głebocka, M | 1 |
| Klimaszyk, D | 1 |
| Mortensen, ME | 1 |
| Cullen, JL | 1 |
| Zhao, P | 1 |
| Slattery, JT | 2 |
| Saseen, JJ | 1 |
| Isbister, GK | 1 |
| Whyte, IM | 1 |
| Downes, F | 1 |
| Dawson, AH | 1 |
| McGettigan, P | 1 |
| Inoue, A | 1 |
| Shimoda, R | 1 |
| Ijima, M | 1 |
| Onda, H | 1 |
| Iida, T | 1 |
| Oshimoto, H | 1 |
| Katakai, K | 1 |
| Masuda, J | 1 |
| Matsumoto, J | 1 |
| Arai, T | 1 |
| Arai, H | 1 |
| Suzuki, Y | 1 |
| Hashimoto, Y | 1 |
| Takagi, H | 1 |
| Mori, M | 1 |
| Hyvernat, H | 1 |
| Vandenbos, F | 1 |
| Anty, R | 1 |
| Barel, R | 1 |
| Demarquay, JF | 1 |
| Saint-Paul, MC | 1 |
| Bernardin, G | 1 |
| Schmidt, LE | 1 |
| Polson, J | 1 |
| Fontana, RJ | 1 |
| Davern, TJ | 1 |
| Lalani, E | 1 |
| Hynan, LS | 1 |
| Reisch, JS | 1 |
| Schiødt, FV | 3 |
| Ostapowicz, G | 1 |
| Shakil, AO | 1 |
| Koff, RS | 1 |
| Boitard, J | 1 |
| Duriez, A | 1 |
| Deltenre, P | 1 |
| Paris, JC | 1 |
| Inoue, S | 1 |
| Yamamoto, I | 1 |
| Akieda, K | 1 |
| Sekiguchi, H | 1 |
| Otuka, H | 1 |
| Morita, S | 1 |
| Nakagawa, Y | 1 |
| Inokuchi, S | 1 |
| Bogdan, GM | 1 |
| Knox, PC | 1 |
| Palmer, RB | 1 |
| Seifert, CF | 1 |
| Anderson, DC | 1 |
| Bartels, S | 1 |
| Sivilotti, M | 1 |
| Crosby, D | 1 |
| Richard, J | 1 |
| Ali, FM | 1 |
| Boyer, EW | 1 |
| Bird, SB | 1 |
| Gómez-Moreno, G | 1 |
| Guardia, J | 1 |
| Cutando, A | 1 |
| Li, B | 1 |
| Dean, S | 1 |
| Quan, H | 1 |
| Levinson, M | 1 |
| Rosen, GM | 1 |
| Singletary, WV | 1 |
| Rauckman, EJ | 1 |
| Killenberg, PG | 1 |
| Prescott, LF | 2 |
| Critchley, JA | 1 |
| Black, M | 2 |
| Himmelstein, DU | 1 |
| Woolhandler, SJ | 1 |
| Adler, RD | 1 |
| Whittington, RM | 1 |
| Altomare, E | 2 |
| Leo, MA | 1 |
| Sato, C | 2 |
| Vendemiale, G | 2 |
| Lieber, CS | 3 |
| Villeneuve, JP | 1 |
| Raymond, G | 1 |
| Bruneau, J | 1 |
| Colpron, L | 1 |
| Pomier-Layrargues, G | 1 |
| Sköld, A | 1 |
| Rönnborg, PE | 1 |
| Dietz, AJ | 1 |
| Carlson, JD | 1 |
| Khalil, SK | 1 |
| Nygard, G | 1 |
| Erickson, RA | 1 |
| Runyon, BA | 1 |
| Goldberg, DM | 1 |
| Pond, S | 1 |
| Jacob, P | 1 |
| Humphreys, M | 1 |
| Weiss, R | 1 |
| Tong, T | 1 |
| Moldéus, P | 1 |
| Andersson, B | 1 |
| Norling, A | 1 |
| Ormstad, K | 1 |
| Matsuda, Y | 1 |
| Johnson, MW | 1 |
| Friedman, PA | 1 |
| Mitch, WE | 1 |
| Gerber, MA | 1 |
| Kaufmann, H | 1 |
| Klion, F | 1 |
| Alpert, LI | 1 |
| McClain, CJ | 2 |
| Kromhout, JP | 1 |
| Peterson, FJ | 1 |
| Holtzman, JL | 3 |
| Zimmerman, HJ | 3 |
| Rumack, BH | 4 |
| Peterson, RC | 1 |
| Koch, GG | 1 |
| Amara, IA | 1 |
| Schueler, L | 1 |
| Harper, JL | 1 |
| Maddrey, WC | 2 |
| Lystbaek, BB | 1 |
| Svendsen, LB | 1 |
| Heslet, L | 1 |
| Smilkstein, MJ | 1 |
| Douglas, DR | 1 |
| Daya, MR | 1 |
| Drenth, JP | 1 |
| Frenken, LA | 1 |
| Wuis, EW | 1 |
| Van der Meer, JW | 1 |
| Whitcomb, DC | 1 |
| Block, GD | 1 |
| Strom, BL | 1 |
| Bonkovsky, HL | 1 |
| Kane, RE | 1 |
| Jones, DP | 1 |
| Galinsky, RE | 1 |
| Banner, B | 1 |
| Guccione, JL | 1 |
| Zemtsov, A | 1 |
| Cobos, E | 1 |
| Neldner, KH | 1 |
| Hanson, L | 1 |
| Girre, C | 1 |
| Hispard, E | 1 |
| Palombo, S | 1 |
| N'Guyen, C | 1 |
| Dally, S | 1 |
| Forster, J | 1 |
| Bartholome, WG | 1 |
| Delcore, R | 1 |
| Johnston, SC | 1 |
| Pelletier, LL | 1 |
| Trinn, C | 2 |
| Szöke, B | 1 |
| Tóth, T | 2 |
| Nagy, J | 2 |
| Rochling, FA | 1 |
| Casey, DL | 1 |
| Makin, AJ | 1 |
| Williams, R | 5 |
| Bernal, W | 1 |
| Rao, RB | 1 |
| Hoffman, RS | 1 |
| Porterfield, LM | 1 |
| Minocha, A | 1 |
| Srinivasan, R | 1 |
| Szp6e, B | 1 |
| Brasch, H | 1 |
| Kenny, JF | 1 |
| Pollack, M | 1 |
| Rothman, R | 1 |
| Flynn, M | 1 |
| Ortiz, MT | 1 |
| Andreu, V | 1 |
| Gómez-Angelats, E | 1 |
| Bruguera, M | 1 |
| Rodés, J | 1 |
| Akça, S | 1 |
| Süleymanlar, I | 1 |
| Tuncer, M | 1 |
| Ersoy, F | 1 |
| Süleymanlar, G | 1 |
| Ivashkin, VT | 1 |
| Fisenko, VP | 1 |
| Sheptulin, AA | 1 |
| Mofredj, A | 1 |
| Cadranel, JF | 1 |
| Darchy, B | 1 |
| Barbare, JC | 1 |
| Cazier, A | 1 |
| Pras, V | 1 |
| Biour, M | 1 |
| Tanaka, E | 1 |
| Yamazaki, K | 1 |
| Misawa, S | 1 |
| van Mil, AH | 1 |
| Janssens, AR | 1 |
| Agarwal, R | 1 |
| Farber, MO | 1 |
| Bondesen, S | 1 |
| Ott, P | 1 |
| Christensen, E | 1 |
| Riordan, SM | 1 |
| Soll, AH | 1 |
| Sees, KL | 1 |
| Oviedo, J | 1 |
| Wolfe, MM | 1 |
| Teschke, R | 1 |
| Stutz, G | 1 |
| Strohmeyer, G | 1 |
| Goldfinger, R | 1 |
| Ahmed, KS | 1 |
| Pitchumoni, CS | 1 |
| Weseley, SA | 1 |
| Emby, DJ | 1 |
| Fraser, BN | 1 |
| Barker, JD | 1 |
| de Carle, DJ | 1 |
| Anuras, S | 1 |
| Prieto, J | 1 |
| Barry, M | 1 |
| Sherlock, S | 1 |
| Knoblauch, M | 1 |
| Lämmli, J | 1 |
| Funk, C | 1 |
| Rex, DK | 2 |
| Kumar, S | 2 |
| Edwards, R | 1 |
| Oliphant, J | 1 |
| Bray, GP | 1 |
| Mowat, C | 1 |
| Muir, DF | 1 |
| Tredger, JM | 3 |
| Denison, H | 2 |
| Kaczynski, J | 2 |
| Wallerstedt, S | 2 |
| Poulsen, HE | 1 |
| Ranek, L | 1 |
| Jørgensen, L | 1 |
| Skinner, MH | 1 |
| Matano, R | 1 |
| Hazle, W | 1 |
| Blaschke, TF | 1 |
| Prasad, JS | 1 |
| Chen, NQ | 1 |
| Liu, YX | 1 |
| Goon, DJ | 1 |
| Wootton, FT | 1 |
| Foust, RT | 1 |
| Reddy, KR | 2 |
| Jeffers, LJ | 1 |
| Schiff, ER | 2 |
| Lauterburg, BH | 1 |
| Velez, ME | 1 |
| Holtzman, J | 1 |
| Allen, J | 1 |
| Kromhout, J | 1 |
| Shedlofsky, S | 1 |
| Keaton, MR | 1 |
| Seeff, LB | 1 |
| Cuccherini, BA | 1 |
| Adler, E | 1 |
| Benjamin, SB | 1 |
| Hall, AH | 2 |
| Kulig, KW | 2 |
| Read, RB | 2 |
| Kartsonis, A | 1 |
| Stufano, N | 1 |
| Di Monte, D | 1 |
| Procacci, V | 1 |
| Albano, O | 1 |
| Raucy, J | 1 |
| Leist, MH | 1 |
| Gluskin, LE | 1 |
| Payne, JA | 1 |
| Fleckenstein, JL | 1 |
| Smith, HM | 1 |
| Portmann, B | 1 |
| Kaysen, GA | 1 |
| Pond, SM | 1 |
| Roper, MH | 1 |
| Menke, DJ | 1 |
| Marrama, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| A Phase 2a Study to Evaluate the Safety and Tolerability of OCR-002 (Ornithine Phenylacetate) in the Treatment of Patients With Acute Liver Failure/Severe Acute Liver Injury[NCT01548690] | Phase 2 | 47 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| Consumer Understanding and Use of Non-Prescription Analgesics, Investigation of Efficacy of Improved Acetaminophen Labeling[NCT01592448] | 662 participants (Actual) | Observational | 2012-10-31 | Completed | |||
| [NCT00137059] | 40 participants | Interventional | 2002-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To evaluate the effect of OCR-002 on ammonia levels in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: Baseline and 72 Hours
| Intervention | Percent Change (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 41.2 |
| Maximum Dose Level 6.65 g/24h | 16.6 |
| Maximum Dose Level 10 g/24h | 41.8 |
| Maximum Dose Level 20g/24h | 38.4 |
To evaluate the steady state pharmacokinetic and pharmacodynamic profile of OCR-002 in patients with impaired and intact renal function using urinary phenylacetylglutamine (PAGN) as a surrogate marker (NCT01548690)
Timeframe: 24 Hours after last infusion
| Intervention | micrograms per millileter (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 65.6 |
| Maximum Dose Level 6.65 g/24h | 32.2 |
| Maximum Dose Level 10 g/24h | 33.4 |
| Maximum Dose Level 20g/24h | 104.9 |
The orientation log focuses on orientation to place, time, and circumstance. There are 10 items on the orientation log, which are scored 0-3. A spontaneous correct response is awarded 3 points. A spontaneous response that is lacking or incorrect, but a correct response is provided following a logical cue is awarded 2 points. A score of 1 is given if spontaneous and cued responses are lacking or incorrect, but a correct response is provided in a recognition format. A score of 0 is given if the spontaneous, cued, or recognition format does not generate a correct answer. Scores from the 10 items are summed and the final score ranges from 0 to 30. (NCT01548690)
Timeframe: 30 Days
| Intervention | units on a scale (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 23.8 |
| Maximum Dose Level 6.65 g/24h | 24.0 |
| Maximum Dose Level 10 g/24h | 24.0 |
| Maximum Dose Level 20g/24h | 24.0 |
The West Haven Criteria (WHC) for Hepatic Encephalopathy measures the severity of encephalopathy and patient's level of consciousness. The scale ranges from 0 to 4; a minimum score of 0 represents a better outcome, and a maximum total score of 4 represents a worse outcome. A score of 0 corresponds to normal consciousness and behavior and normal neurological examination. A score of 1 corresponds to mild lack of awareness, shortened attention span, and impaired addition or subtraction; mild asterixis or tremor. A score of 2 corresponds to lethargy, disorientated or inappropriate behavior, obvious asterixis; slurred speech. A score of 3 corresponds to somnolent but arousable, gross disorientation or bizarre behavior, muscle rigidity and clonus; hyperreflexia. A score of 4 corresponds to coma and decerebrate posturing. (NCT01548690)
Timeframe: 120 hours from start of infusion
| Intervention | units on a scale (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 2.4 |
| Maximum Dose Level 6.65 g/24h | 3.2 |
| Maximum Dose Level 10 g/24h | 1.6 |
| Maximum Dose Level 20g/24h | 1.8 |
To evaluate the safety and tolerability of OCR-002 in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: 30 Days
| Intervention | Participants (Count of Participants) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 0 |
| Maximum Dose Level 6.65 g/24h | 0 |
| Maximum Dose Level 10 g/24h | 0 |
| Maximum Dose Level 20g/24h | 0 |
20 reviews available for acetaminophen and Alcoholism
| Article | Year |
|---|---|
Management of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Alcoholism; Analgesics, Non-Narcotic; Antidotes; Chemistry, Pharmaceu | 2003 |
[Problems with therapeutic acetaminophen use in excessive drinkers].
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; | 2006 |
[Alcohol abuse case of severe liver dysfunction induced by acetaminophen poisoning which was diagnosed as non-hepatic toxicity on admission].
Topics: Acetaminophen; Acetylcysteine; Administration, Rectal; Adult; Alcoholism; Analgesics, Non-Narcotic; | 2006 |
Interaction of paracetamol in chronic alcoholic patients. Importance for odontologists.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Drug Interactions; Ethanol; Female; Humans; Mal | 2008 |
Drug interactions affecting analgesic toxicity.
Topics: Acetaminophen; Alcoholic Intoxication; Alcoholism; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 1983 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Adult; Aged; Alcoholism; Chemical and Drug Induced Liver Injury; Chemical Phenomena; | 1984 |
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry.
Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; E | 1980 |
Acetaminophen toxicity: report of case and review of the literature.
Topics: Acetaminophen; Adult; Alcoholism; Analgesics, Non-Narcotic; Blood Coagulation; Chemical and Drug Ind | 1995 |
[Paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Alcoholism; Charcoal; Denmark; Intestinal Absorption; Kidney; Liver; | 1995 |
Enhanced hepatotoxicity of acetaminophen in the alcoholic patient. Two case reports and a review of the literature.
Topics: Acetaminophen; Adult; Alcoholism; Fatal Outcome; Female; Humans; Liver; Male; Middle Aged | 1997 |
[Severe hepatitis from therapeutic doses of paracetamol in an alcoholic patient].
Topics: Acetaminophen; Acute Disease; Adult; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced | 1999 |
[Non-narcotic analgesics, alcohol and liver].
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Humans; Liver | 1999 |
[Hepatotoxicity caused by therapeutic doses of paracetamol in alcoholics. Report of 2 cases of fatal hepatitis in cirrhosis].
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; | 1999 |
Paracetamol, alcohol and the liver.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Central Nervous System Depressants; Ethanol; Hu | 2000 |
Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Humans; Liver | 2000 |
Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Clinical Trials as Topic; Fever; Humans; Liver; | 2000 |
Alcohol exposure and paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Alcohol Drinking; Alcoholism; Chemical and Drug Induced Liver Injury; Dose-Response R | 2002 |
Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure.
Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Blood Coagulati | 1986 |
Hepatic effects of acetaminophen. Enhanced toxicity in alcoholics.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Ethanol; Humans; Liver; Liver Dis | 1987 |
[Recent findings on the hepatotoxicity of drugs].
Topics: Acetaminophen; Alcoholism; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cytoc | 1985 |
5 trials available for acetaminophen and Alcoholism
| Article | Year |
|---|---|
The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study.
Topics: Acetaminophen; Adult; Aged; Alcoholism; Analgesics, Non-Narcotic; Double-Blind Method; Female; Gluta | 2010 |
Acetaminophen-cysteine adducts during therapeutic dosing and following overdose.
Topics: Acetaminophen; Adolescent; Adult; Alcohol Drinking; Alcoholism; Biomarkers; Chemical and Drug Induce | 2011 |
Does acetaminophen affect liver function in alcoholic patients?
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Double- | 2003 |
The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study.
Topics: Acetaminophen; Adolescent; Adult; Alanine Transaminase; Alcoholism; Analgesics, Non-Narcotic; Aspart | 2007 |
Are recommended doses of acetaminophen hepatotoxic for recently abstinent alcoholics? A randomized trial.
Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Analgesics, Non-Narcotic; Aspartate Aminotra | 2008 |
96 other studies available for acetaminophen and Alcoholism
| Article | Year |
|---|---|
Aggressive Treatment of Life-Threatening Hypophosphatemia During Recovery From Fulminant Hepatic Failure: A Case Report.
Topics: Acetaminophen; Adult; Alcoholism; Clinical Protocols; Critical Care; Drug Overdose; Humans; Hypophos | 2018 |
Beware of paracetamol use in alcohol abusers: a potential cause of acute liver injury.
Topics: Acetaminophen; Alanine Transaminase; Alcoholism; Analgesics, Non-Narcotic; Aspartate Aminotransferas | 2013 |
Coricidin HBP abuse: patient characteristics and psychiatric manifestations as recorded in an inpatient psychiatric unit.
Topics: Acetaminophen; Adolescent; Age Factors; Alcoholism; California; Child; Chlorpheniramine; Comorbidity | 2008 |
[Therapeutic misadventure with acetaminophen in alcoholics].
Topics: Acetaminophen; Alcoholism; Drug Overdose; Humans | 2009 |
Hepatitis C, alcohol abuse, and unintentional overdoses are risk factors for acetaminophen-related hepatotoxicity.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induced Liver Injury; | 2009 |
Thinking through acetaminophen hepatotoxicity and liver transplantation: choosing worthy recipients.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Drug Overdose; Humans; Kaplan-Meier Estimate; L | 2009 |
The utilization of liver transplantation in the management of acute liver failure: comparison between acetaminophen and non-acetaminophen etiologies.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; Analgesics, Non-Narcotic; Cohort Studies; Contra | 2009 |
Acute liver failure after administration of paracetamol at the maximum recommended daily dose in adults.
Topics: Acetaminophen; Adult; Alcoholism; Analgesics, Non-Narcotic; Crohn Disease; Fatal Outcome; Female; Hu | 2010 |
Should a lower treatment line be used when treating paracetamol poisoning in patients with chronic alcoholism?: a case for.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Drug | 2002 |
Should a lower treatment line be used when treating paracetamol poisoning in patients with chronic alcoholism?: a case against.
Topics: Acetaminophen; Acetylcysteine; Alcoholism; Analgesics, Non-Narcotic; Animals; Dose-Response Relation | 2002 |
[Alcohol-paracetamol syndrome: a case report].
Topics: Acetaminophen; Acute Disease; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Humans; Mal | 2002 |
Comment: hepatotoxicity associated with chronic acetaminophen administration in patients without risk factors.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chronic | 2002 |
Effects of ethanol dose and ethanol withdrawal on rat liver mitochondrial glutathione: implication of potentiated acetaminophen toxicity in alcoholics.
Topics: Acetaminophen; Alcoholism; Animals; Dose-Response Relationship, Drug; Ethanol; Glutathione; Male; Mi | 2002 |
Concomitant overdosing of other drugs in patients with paracetamol poisoning.
Topics: Acetaminophen; Alcoholism; Benzodiazepines; Drug Overdose; Humans; Risk Factors | 2003 |
[Case report: habitual alcohol drinking caused early onset of acetaminophen-induced severe liver damage].
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Humans; Male | 2003 |
[Fulminant hepatitis after a therapeutic dose of acetaminophen in a chronic alcoholic patient].
Topics: Acetaminophen; Adult; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; | 2004 |
Age and paracetamol self-poisoning.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Age Factors; Aged; Aged, 80 and over; Alcoholism | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; APACHE; Drug Overdose; Female; Humans; Liver Fai | 2005 |
Osteoarthritis of the knee.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Humans; Liver Diseases; Osteoarthritis, Knee | 2006 |
Acetaminophen usage patterns and concentrations of glutathione and gamma-glutamyl transferase in alcoholic subjects.
Topics: Acetaminophen; Adult; Alcohol Drinking; Alcoholism; Analgesics, Non-Narcotic; Biomarkers, Pharmacolo | 2007 |
Estimated risk of hepatotoxicity after an acute acetaminophen overdose in alcoholics.
Topics: Acetaminophen; Acetylcysteine; Alcoholism; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induc | 2008 |
Impact of liver disease, alcohol abuse, and unintentional ingestions on the outcomes of acetaminophen overdose.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholism; Child; Child, Preschool; Drug | 2008 |
Ulcer, back pain, and jaundice in an alcoholic.
Topics: Acetaminophen; Adult; Alcoholism; Back Pain; Chemical and Drug Induced Liver Injury; Dextropropoxyph | 1983 |
Acetaminophen hepatotoxicity. An alternative mechanism.
Topics: Acetaminophen; Alcoholism; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Crice | 1983 |
Elevated SGOT/SGPT ratio in alcoholic patients with acetaminophen hepatotoxicity.
Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Chemical and Dr | 1984 |
Dextropropoxyphene deaths: coroner's report.
Topics: Acetaminophen; Adult; Alcoholism; Dextropropoxyphene; Drug Combinations; Humans; Middle Aged; Opioid | 1984 |
Interaction of ethanol with acetaminophen metabolism in the baboon.
Topics: Acetaminophen; Alcoholism; Animals; Drug Interactions; Ethanol; Female; Humans; Kinetics; Liver; Pap | 1984 |
[Pharmacokinetics and metabolism of acetaminophen in normal, alcoholic and cirrhotic subjects].
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Humans; Kinetics; Liver Ci | 1983 |
[Does paracetamol cause liver damage in chronic alcoholics?].
Topics: Acetaminophen; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Female; Humans; Liver; | 1984 |
Effects of alcoholism on acetaminophen pharmacokinetics in man.
Topics: Acetaminophen; Adult; Alcoholism; Female; Humans; Kinetics; Liver; Male; Middle Aged | 1984 |
Acetaminophen hepatotoxicity associated with alcoholic pancreatitis.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Humans; Pancreatitis; Substance-R | 1984 |
Impaired metabolism of methylphenobarbital after a combined drug overdose: treatment by resin hemoperfusion.
Topics: Acetaminophen; Adult; Alcoholic Intoxication; Alcoholism; Coma; Drug Interactions; Female; Hemoperfu | 1982 |
Effect of chronic ethanol administration on drug metabolism in isolated hepatocytes with emphasis on paracetamol activation.
Topics: Acetaminophen; Alcoholism; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Glutathione; | 1980 |
Increased hepatotoxicity of acetaminophen after chronic ethanol consumption in the rat.
Topics: Acetaminophen; Alcoholism; Aminopyrine N-Demethylase; Animals; Aspartate Aminotransferases; Chemical | 1981 |
Alcoholism, nonprescription drug and hepatotoxicity. The risk from unknown acetaminophen ingestion.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Femal | 1981 |
Acetaminophen associated hepatic injury, Report of two cases showing unusual portal tract reactions.
Topics: Acetaminophen; Acute Disease; Acute Kidney Injury; Adult; Alcoholism; Biopsy; Chemical and Drug Indu | 1980 |
Potentiation of acetaminophen hepatotoxicity by alcohol.
Topics: Acetaminophen; Adult; Alcoholism; Drug Synergism; Ethanol; Humans; Liver; Male; Middle Aged; Necrosi | 1980 |
Dr. Henry Baker Lecture Interaction of ethanol with drug toxicity.
Topics: Acetaminophen; Alcoholic Beverages; Alcoholic Intoxication; Alcoholism; Animals; Carbon Tetrachlorid | 1980 |
Effects of aspirin and acetaminophen on the liver.
Topics: Acetaminophen; Adolescent; Adult; Alcoholism; Arthritis, Juvenile; Aspirin; Child; Female; Humans; L | 1981 |
Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alcoholism; Aspartate Aminotransferases; Drug E | 1981 |
Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure.
Topics: Acetaminophen; Adult; Alcoholism; Aspartate Aminotransferases; Dose-Response Relationship, Drug; Dru | 1995 |
Acetaminophen poisoning and liver function.
Topics: Acetaminophen; Alcoholism; Animals; Drug Overdose; Humans; Liver | 1994 |
Acute renal failure associated with paracetamol ingestion in an alcoholic patient.
Topics: Acetaminophen; Acute Kidney Injury; Administration, Oral; Adult; Alcoholism; Ethanol; Humans; Male | 1994 |
Association of acetaminophen hepatotoxicity with fasting and ethanol use.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcohol Drinking; Alcoholism; Chemical and Drug Induced Live | 1994 |
Adverse reactions to over-the-counter analgesics taken for therapeutic purposes.
Topics: Acetaminophen; Alcoholism; Analgesics; Chemical and Drug Induced Liver Injury; Ethanol; Fasting; Hum | 1994 |
Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency.
Topics: Acetaminophen; Aged; Alcoholism; Chronic Disease; Glutathione; Heart Failure; Humans; Kidney; Liver; | 1994 |
Acquired purpura fulminans induced by alcohol and acetaminophen. Successful treatment with heparin and vitamin K.
Topics: Acetaminophen; Adult; Alcoholism; Drug Therapy, Combination; Female; Heparin; Humans; Purpura; Skin; | 1993 |
Acute hepatic decompensation in an alcoholic.
Topics: Acetaminophen; Acute Disease; Alcoholism; Chemical and Drug Induced Liver Injury; Humans; Male; Midd | 1993 |
Increased metabolism of acetaminophen in chronically alcoholic patients.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Dose-Response Relationship | 1993 |
Should a patient who attempted suicide receive a liver transplant?
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Drug Overdose; Ethicists; | 1996 |
Paracetamol induced acute interstitial nephritis superimposed on mesangiocapillary glomerulonephritis.
Topics: Acetaminophen; Adult; Alcoholism; Anti-Inflammatory Agents, Non-Steroidal; Glomerulonephritis, Membr | 1996 |
Acetaminophen toxicity in an urban county hospital.
Topics: Accidents; Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholism; Chemical and Drug | 1997 |
Acetaminophen toxicity in an urban county hospital.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Dise | 1998 |
Acetaminophen toxicity in an urban county hospital.
Topics: Acetaminophen; Alcoholism; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug | 1998 |
Right upper quadrant tenderness in a drinker.
Topics: Abdominal Pain; Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Humans; Liver Failure; Male; Mi | 1998 |
Ethanol-acetaminophen cocktail: the debate continues!
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Retrospect | 1998 |
[Paracetamol-induced tubulointerstitial nephritis in a chronic alcoholic patient].
Topics: Acetaminophen; Acute Disease; Adult; Alcoholism; Biopsy; Chemical and Drug Induced Liver Injury; Chr | 1998 |
Routine screening for acetaminophen (APAP) toxicity of patients requesting alcohol detoxification.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; | 1999 |
Isolated acute renal failure due to paracetamol intoxication in an alcoholic patient.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcoholism; Analgesics, Non-Narcotic; Humans; Male | 1999 |
[Acetaminophen use by chronic alcohol abusers: a therapeutic dose may be too much for the liver].
Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Alcoholism; Analgesics, Non-Narcotic; Aspartate Am | 2001 |
Use of acetaminophen in alcoholic patients: comment on the 2000 update of the American College of Rheumatology recommendations for management of hip and knee osteoarthritis.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Humans; Osteoarthritis, Hip; Osteoarthritis, Kn | 2001 |
Is continuous veno-venous hemofiltration for acetaminophen-induced acute liver and renal failure worthwhile?
Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcoholism; Analgesics, Non-Narcotic; Drug Overdose; Hemo | 2002 |
Influence of acute and chronic alcohol intake on the clinical course and outcome in acetaminophen overdose.
Topics: Acetaminophen; Alcoholic Intoxication; Alcoholism; Drug Overdose; Female; Hepatic Encephalopathy; Hu | 2002 |
The effect of alcohol on acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alcoholism; Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Ethanol; | 2002 |
Is acetaminophen really safe in alcoholic patients?
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Male; Risk | 2002 |
Alcohol, acetaminophen, and toxic effects on the liver.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Humans; Liver; Risk | 2002 |
Increased paracetamol-induced hepatotoxicity after chronic alcohol consumption.
Topics: Acetaminophen; Alanine Transaminase; Alcoholism; Animals; Aspartate Aminotransferases; Ethanol; Fema | 1979 |
Concomitant alcohol and drug abuse enhancing acetaminophen toxicity. Report of a case.
Topics: Acetaminophen; Adult; Alcoholic Intoxication; Alcoholism; Chemical and Drug Induced Liver Injury; Fe | 1978 |
Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans | 1977 |
Chronic excessive acetaminophen use and liver damage.
Topics: Acetaminophen; Aged; Alcoholism; Carcinoma, Squamous Cell; Chemical and Drug Induced Liver Injury; F | 1977 |
Serum ferritin in patients with iron overload and with acute and chronic liver diseases.
Topics: Acetaminophen; Alcoholism; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug | 1975 |
[Drug-induced liver diseases].
Topics: Acetaminophen; Adult; Alcoholism; Azathioprine; Bilirubin; Chemical and Drug Induced Liver Injury; C | 1975 |
Recognizing acetaminophen hepatotoxicity in chronic alcoholics.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Ove | 1992 |
Paracetamol toxicity in chronic alcohol abusers--a plea for greater consumer awareness.
Topics: Acetaminophen; Alcoholism; Gastritis; Health Education; Humans; Liver; Male; Middle Aged; Necrosis | 1992 |
The effect of chronic alcohol intake on prognosis and outcome in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Alcoholism; Aspartate Aminotransferases; Brain Edema; Chemical | 1991 |
[Paracetamol in therapeutic dosages can cause severe hepatic and renal damage in alcoholics].
Topics: Acetaminophen; Adult; Aged; Alcoholism; Chemical and Drug Induced Liver Injury; Female; Humans; Kidn | 1991 |
Failure of physicians to recognize acetaminophen hepatotoxicity in chronic alcoholics.
Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Chemical | 1991 |
The influence of disulfiram on acetaminophen metabolism in man.
Topics: Acetaminophen; Adult; Aged; Alcoholism; Disulfiram; Drug Interactions; Female; Humans; Liver Cirrhos | 1991 |
Acetaminophen metabolism in recovering alcoholics.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Aged; Alcoholism; Female; Humans; Longit | 1990 |
Effects of ethanol and inhibitors on the binding and metabolism of acetaminophen and N-acetyl-p-benzoquinone imine by hepatic microsomes from control and ethanol-treated rats.
Topics: Acetaminophen; Alcoholism; Animals; Benzoquinones; Cysteine; Ethanol; Imines; Male; Microsomes, Live | 1990 |
Acetaminophen hepatotoxicity in the alcoholic.
Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Chemical and Dr | 1990 |
Nyquil-associated liver injury.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Dextromethorphan; Doxylami | 1989 |
Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Humans; Li | 1988 |
Clinical features of acetaminophen toxicity.
Topics: Acetaminophen; Adolescent; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Female; Humans | 1988 |
Acute renal failure in an alcoholic during therapeutic acetaminophen ingestion.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcoholism; Headache; Humans; Kidney Tubular Necrosis, Ac | 1988 |
Acetaminophen and alcoholics.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Humans; Risk | 1987 |
Paracetamol medication and alcohol abuse: a dangerous combination for the liver and the kidney.
Topics: Acetaminophen; Adolescent; Adult; Alcoholism; Aspartate Aminotransferases; Chemical and Drug Induced | 1987 |
Analysis of factors responsible for continuing mortality after paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Alcoholism; Antidotes; Dextropropoxyphene; Disseminated I | 1986 |
Alcohol, acetaminophen, and hepatic necrosis.
Topics: Acetaminophen; Adult; Alcoholism; Humans; Liver Diseases; Male; Necrosis | 1986 |
Acetaminophen hepatotoxicity in alcoholics.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Female; Humans; Male | 1986 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Humans | 1986 |
Acetaminophen, alcohol, and cytochrome P-450.
Topics: Acetaminophen; Alcoholism; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme | 1986 |
Enhanced toxicity of acetaminophen in alcoholics: report of three cases.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Drug Interactions; Ethanol | 1985 |
Nyquil and acute hepatic necrosis.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Dextromethorphan; Doxylami | 1985 |
Effects of ethanol ingestion on the hepatotoxicity and metabolism of paracetamol in mice.
Topics: Acetaminophen; Alcohol Drinking; Alcoholism; Animals; Chemical and Drug Induced Liver Injury; Cytoch | 1985 |
Combined hepatic and renal injury in alcoholics during therapeutic use of acetaminophen.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Diagn | 1985 |